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https://www.readbyqxmd.com/read/27663366/investigating-the-potential-role-of-vitamin-e-in-modulating-the-immunosuppressive-effects-of-tylvalosin-and-florfenicol-in-broiler-chickens
#1
Fatma I Abo El-Ela, S A S Shany, Manal B El-Deen, H A El-Banna, A A El-Gendy, K Hendy, M A Tohamy
Tylvalosin (TVS) is a third-generation macrolide drug used for prophylaxis and treatment of mycoplasma, however; it is supposed to possess an immunosuppressive effect. In the current study, the immunosuppressive effect of TVS and florfenicol (FFC) and the potential immunomodulatory role of Vit E were investigated. The experiment included one day old chick groups treated with either TVS, FFC, Vit E, TVS/Vit E, FFC/Vit E and control non-treated group. Chicks were vaccinated with inactivated H9N2 avian influenza (AI) vaccine and humoral antibody titers to viral antigen as well as innate immunity (serum lysozyme activity and nitric oxide levels) were evaluated...
October 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27543140/antibiotic-susceptibility-profiles-of-mycoplasma-sp-1220-strains-isolated-from-geese-in-hungary
#2
Dénes Grózner, Zsuzsa Kreizinger, Kinga M Sulyok, Zsuzsanna Rónai, Veronika Hrivnák, Ibolya Turcsányi, Szilárd Jánosi, Miklós Gyuranecz
BACKGROUND: Mycoplasma sp. 1220 can induce inflammation primarily in the genital and respiratory tracts of waterfowl, leading to serious economic losses. Adequate housing and appropriate antibiotic treatment are promoted in the control of the disease. The aim of the present study was to determine the in vitro susceptibility to thirteen different antibiotics and an antibiotic combination of thirty-eight M. sp. 1220 strains isolated from geese and a duck in several parts of Hungary, Central Europe between 2011 and 2015...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27504836/antimicrobial-susceptibility-of-brachyspira-hyodysenteriae-in-switzerland
#3
C Kirchgässner, S Schmitt, A Borgström, M M Wittenbrink
Brachyspira (B.) hyodysenteriae is the causative agent of swine dysentery (SD), a severe mucohaemorrhagic diarrheal disease in pigs worldwide. So far, the antimicrobial susceptibility patterns of B. hyodysenteriae in Switzerland have not been investigated. Therefore, a panel of 30 porcine B. hyodysenteriae isolates were tested against 6 antimicrobial agents by using the VetMIC Brachy panel, a broth microdilution test. Tiamulin and valnemulin showed high antimicrobial activity inhibiting all isolates at low concentrations...
June 2016: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/27086612/concentrations-of-tylvalosin-and-3-o-acetyltylosin-attained-in-the-synovial-fluid-of-swine-after-administration-by-oral-gavage-at-50-and-5%C3%A2-mg-kg
#4
P Canning, J Bates, K Hammen, J Coetzee, L Wulf, S Rajewski, C Wang, L Karriker
The objectives of this study were to determine the concentration of tylvalosin (TVN) and its metabolite, 3-O-acetyltylosin (3AT) in the synovial fluid of growing pigs when administered as a single bolus by oral gavage at target doses of 50 mg/kg (Trial 1) and 5 mg/kg (Trial 2). TVN is a water soluble macrolide antimicrobial used in swine production. The stability of the drug in synovial fluid samples stored at -70 °C up to 28 days was also evaluated in Trial 2. In Trial 1, eight pigs were randomly assigned to one of eight time points for euthanasia and synovial fluid collection: 0, 1, 2, 3, 4, 6, 9, 12 h postgavage...
April 17, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26584828/intestinal-spirochaetes-genus-brachyspira-colonise-wild-birds-in-the-southern-atlantic-region-and-antarctica
#5
Désirée S Jansson, Memoona Mushtaq, Karl-Erik Johansson, Jonas Bonnedahl, Jonas Waldenström, Dan I Andersson, Tina Broman, Charlotte Berg, Björn Olsen
INTRODUCTION: The genus Brachyspira contains well-known enteric pathogens of veterinary significance, suggested agents of colonic disease in humans, and one potentially zoonotic agent. There are recent studies showing that Brachyspira are more widespread in the wildlife community than previously thought. There are no records of this genus in wildlife from the southern Atlantic region and Antarctica. Our aim was therefore, to determine whether intestinal spirochaetes of genus Brachyspira colonise marine and coastal birds in this region...
2015: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/26392896/use-of-tylvalosin-in-the-control-of-porcine-enzootic-pneumonia
#6
F J Pallarés, C Lasa, M Roozen, G Ramis
OBJECTIVES: The purpose of this study was to investigate the efficacy of tylvalosin (Aivlosin Water Soluble Granules, ECO Animal Health) in drinking water for control of Mycoplasma hyopneumoniae (M hyo) on a farm with chronic enzootic pneumonia (EP) problems and high prevalence of mycoplasma-like lesions at slaughter. DESIGN: On a 4000-sow farm in the southeast of Spain, 1500 animals of same age were randomly divided into two groups: 900 pigs in the treated group (TG) and 600 pigs in the non-treated control group (CG)...
2015: Veterinary Record Open
https://www.readbyqxmd.com/read/25185108/in-vitro-activity-of-tylvalosin-against-spanish-field-strains-of-mycoplasma-hyopneumoniae
#7
M M Tavío, C Poveda, P Assunção, A S Ramírez, J B Poveda
Mycoplasma hyopneumoniae is involved in the porcine enzootic pneumonia and respiratory disease complex; therefore, the search for new treatment options that contribute to the control of this organism is relevant. The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations of tylvalosin and 19 other antimicrobial agents against 20 Spanish field isolates of M. hyopneumoniae were determined using the broth microdilution method, with the type strain (J) as a control strain. Tylvalosin had MIC50 and MIC90 values of 0...
November 29, 2014: Veterinary Record
https://www.readbyqxmd.com/read/24792436/tylvalosin-exhibits-anti-inflammatory-property-and-attenuates-acute-lung-injury-in-different-models-possibly-through-suppression-of-nf-%C3%AE%C2%BAb-activation
#8
Zhanzhong Zhao, Xiangfang Tang, Xinghui Zhao, Minhong Zhang, Weijian Zhang, Shaohua Hou, Weifeng Yuan, Hongfu Zhang, Lijun Shi, Hong Jia, Lin Liang, Zhi Lai, Junfeng Gao, Keyu Zhang, Ling Fu, Wei Chen
Tylvalosin, a new broad-spectrum, third-generation macrolides, may exert a variety of pharmacological activities. Here, we report on its anti-oxidative and anti-inflammatory activity in RAW 264.7 macrophages and mouse treated with lipopolysaccharide (LPS) as well as piglet challenged with porcine reproductive and respiratory syndrome virus (PRRSV). Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1β, PGE2, TNF-α and NO levels in vitro and in vivo. LPS and PRRSV-induced reactive oxygen species (ROS) production, and the lipid peroxidation in mice lung tissues reduced after tylvalosin treatments...
July 1, 2014: Biochemical Pharmacology
https://www.readbyqxmd.com/read/23948134/characterization-of-treponema-spp-isolates-from-pigs-with-ear-necrosis-and-shoulder-ulcers
#9
Olov Svartström, Frida Karlsson, Claes Fellström, Märit Pringle
Ear necrosis and shoulder ulcers in pigs are animal welfare problems and ethical issues that can cause economic losses for producers. Spirochetes have been observed microscopically in scrapings from pig ulcers since the early 1900s, but have until recently not been cultured and therefore not characterized. In this study, 12 Treponema spp. isolates were acquired from porcine ear necrosis, shoulder ulcers and gingiva. DNA analysis of the 16S rRNA-tRNA(Ile) intergenic spacer region (ISR2) or the 16S rRNA gene revealed relatedness to oral treponemes found in dogs and humans...
October 25, 2013: Veterinary Microbiology
https://www.readbyqxmd.com/read/23472021/efficacy-of-low-dose-tylvalosin-for-the-control-of-clostridiosis-in-broilers-and-its-effect-on-productive-parameters
#10
C Garcés-Narro, J I Barragán, M D Soler, M Mateos, M C López-Mendoza, J Homedes
The study was carried out under field conditions in a commercial farm, and 1,440 as-hatched Ross-308 broilers were included. Broilers were randomly distributed into 24 experimental 4-m(2) pens (60 broilers/pen). Pens were randomized to the 3 treatment groups: a) tylvalosin 10 mg/kg of live BW during 2 d, b) positive control (tylosin during 2 d), and c) negative control (no treatment). The drugs were provided in the water supply. Mortality, individual BW, and feed intake were assessed. Clostridium presence was assessed in fecal and cecal samples, coccidian oocyst counts were assessed in fecal samples, and bacterial diversity was assessed in ileal content...
April 2013: Poultry Science
https://www.readbyqxmd.com/read/22998753/antimicrobial-susceptibility-of-porcine-brachyspira-hyodysenteriae-and-brachyspira-pilosicoli-isolated-in-sweden-between-1990-and-2010
#11
Märit Pringle, Annica Landén, Helle Ericsson Unnerstad, Benedicta Molander, Björn Bengtsson
BACKGROUND: The anaerobic spirochetes Brachyspira hyodysenteriae and Brachyspira pilosicoli cause diarrheal diseases in pigs. Their fastidious nature has hampered standardization of methods for antimicrobial susceptibility testing. For monitoring of antimicrobial susceptibility wild type cutoff values are needed to define where the wild type distribution of MICs ends and no approved cutoffs are available for Brachyspira spp. In this study antimicrobial susceptibility data for both species (in total 906 isolates) were compiled and analyzed and wild type cut off values for B...
2012: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/22367248/validation-of-a-multi-residue-method-for-the-determination-of-several-antibiotic-groups-in-honey-by-lc-ms-ms
#12
Detlef A Bohm, Carolin S Stachel, Petra Gowik
The presented multi-method was developed for the confirmation of 37 antibiotic substances from the six antibiotic groups: macrolides, lincosamides, quinolones, tetracyclines, pleuromutilines and diamino-pyrimidine derivatives. All substances were analysed simultaneously in a single analytical run with the same procedure, including an extraction with buffer, a clean-up by solid-phase extraction, and the measurement by liquid chromatography tandem mass spectrometry in ESI+ mode. The method was validated on the basis of an in-house validation concept with factorial design by combination of seven factors to check the robustness in a concentration range of 5-50 μg kg(-1)...
July 2012: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/22107092/mycoplasma-gallisepticum-in-pheasants-and-the-efficacy-of-tylvalosin-to-treat-the-disease
#13
C Anne Forrester, Janet M Bradbury, Cynthia M Dare, Rickie J Domangue, Helena Windsor, John B Tasker, A P Adrian Mockett
Infectious sinusitis, a common condition seen in adult pheasants, is primarily caused by Mycoplasma gallisepticum. The aims of the present study were to investigate the pathogenicity of M. gallisepticum in 14-day-old pheasants and evaluate the macrolide antibiotic tylvalosin (TVN) as a treatment for infectious sinusitis. The minimum inhibitory concentration of TVN for five isolates of M. gallisepticum taken from pheasants confirmed their susceptibility to TVN (range: 0.002 to 0.008 µg/ml). One of the isolates (G87/02) was inoculated intranasally into 72 pheasants (two groups of 36) at 14 days of age...
December 2011: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/21555771/trends-towards-lower-antimicrobial-susceptibility-and-characterization-of-acquired-resistance-among-clinical-isolates-of-brachyspira-hyodysenteriae-in-spain
#14
Álvaro Hidalgo, Ana Carvajal, Birte Vester, Märit Pringle, Germán Naharro, Pedro Rubio
The antimicrobial susceptibility of clinical isolates of Brachyspira hyodysenteriae in Spain was monitored, and the underlying molecular mechanisms of resistance were investigated. MICs of tylosin, tiamulin, valnemulin, lincomycin, and tylvalosin were determined for 87 B. hyodysenteriae isolates recovered from 2008 to 2009 by broth dilution. Domain V of the 23S rRNA gene and the ribosomal protein L3 gene were sequenced in 20 isolates for which the tiamulin MIC was ≥ 4 μg/ml, presenting decreased susceptibility, and in 18 tiamulin-susceptible isolates (MIC ≤ 0...
July 2011: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/20444046/impact-of-the-type-of-catheter-on-the-absorption-of-tylvalosin-acetylvaleryltylosin-administered-orally-to-broiler-chickens
#15
R O Cerdá, M Petruccelli, M Piscopo, J Origlia, M Landoni
No abstract text is available yet for this article.
April 2010: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/19767637/use-of-tylvalosin-medicated-feed-to-control-porcine-proliferative-enteropathy
#16
RANDOMIZED CONTROLLED TRIAL
R M C Guedes, S A França, G S Machado, M A Blumer, E C da Costa Cruz
The effect of an oral treatment with the tartrate salt of tylvalosin on the development of proliferative enteropathy in 60 experimentally challenged pigs was studied. Thirty of the pigs were fed a diet medicated with 50 ppm tylvalosin and 30 were fed the unmedicated diet. The treated animals started to receive the medicated feed the day before they were inoculated, and continued to receive it for 14 days. The pigs' bodyweight, feed consumption and clinical signs were evaluated, and they were examined postmortem 20 days after inoculation, and samples of ileum were collected for immunohistochemistry (IHC) for Lawsonia intracellularis...
September 19, 2009: Veterinary Record
https://www.readbyqxmd.com/read/18767301/-multiresistant-brachyspira-hyodysenteriae-in-a-dutch-sow-herd
#17
T F Duinhof, C M Dierikx, M G J Koene, M A P van Bergen, D J Mevius, K T Veldman, H M G van Beers-Schreurs, R T J A de Winne
This case study describes the isolation ofa multiresistant strain ofBrachyspira hyodysenteriae in April 2007 in a Dutch sow herd with recurrent diarrhoea. Examination of faecal samples taken from 7-month-old breeding gilts with diarrhoea revealed the presence of resistance against tiamulin, lincomycin, tylosin, doxycycline, and tylvalosin (the active substance in Aivlosin) in four of five samples. Tiamulin resistance has not been reported in The Netherlands before. The repeated use of tiamulin on the affected farm was assumed to be the main cause of the development of resistance to the drug...
July 15, 2008: Tijdschrift Voor Diergeneeskunde
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