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Canine T cells

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https://www.readbyqxmd.com/read/28621057/prospective-evaluation-of-toceranib-phosphate-in-metastatic-canine-osteosarcoma
#1
T Laver, C A London, D M Vail, B J Biller, J Coy, D H Thamm
Efficacious therapies for measurable metastatic canine osteosarcoma (OSA) are generally lacking. Preliminary retrospective studies suggested that approximately 50% of dogs with measurable metastatic OSA experienced clinical benefit (objective response or clinically meaningful disease stabilisation) following toceranib (TOC) treatment. The purpose of this clinical trial was to prospectively evaluate the clinical outcome following TOC treatment in dogs with measurable pulmonary metastatic OSA. A secondary goal was to identify potential biomarkers of clinical benefit by measuring changes in plasma vascular endothelial growth factor (VEGF) and circulating regulatory T-cell (Treg) percentage...
June 15, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28620374/canine-macrophage-dh82-cell-line-as-a-model-to-study-susceptibility-to-trypanosoma-cruzi-infection
#2
Pedro Henrique Braz Mendonça, Raphael Francisco Dutra Barbosa da Rocha, Julliane Brito de Braz Moraes, Isabel Ferreira LaRocque-de-Freitas, Jorgete Logullo, Alexandre Morrot, Marise Pinheiro Nunes, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo
Trypanosoma cruzi is an obligatory intracellular protozoan parasite, and it is the etiological agent of Chagas' disease that is endemic in the Americas. In addition to humans, a wide spectrum of mammals can be infected by T. cruzi, including dogs. Dogs develop acute and chronic disease, similar to human infection. T. cruzi can infect almost all cell types and after cell invasion, the metacyclics trypomastigotes localize in the cytoplasm, where they transform into amastigotes, the replicative form of T. cruzi in mammals...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28615132/identification-of-a-secondary-mutation-in-the-kit-kinase-domain-correlated-with-imatinib-resistance-in-a-canine-mast-cell-tumor
#3
Yuko Nakano, Masato Kobayashi, Makoto Bonkobara, Masamine Takanosu
Imatinib-resistance is a major therapeutic problem in human chronic myeloid leukemia, human gastrointestinal stromal tumors, and canine mast cell tumors. In the present study, we identified the secondary mutation c.2006C>T in c-KIT exon 14 in a mast cell tumor obtained from a dog carrying c.1663-1671del in exon 11 and showing resistance to imatinib. The mutation in exon 14 resulted in substitution of threonine with isoleucine at position 669, which was located at the center of the ATP binding site as a gatekeeper and played an important role in binding to imatinib...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28608404/apoptotic-intrinsic-pathway-proteins-predict-survival-in-canine-cutaneous-mast-cell-tumours
#4
C N Barra, B M Macedo, K G Cadrobbi, L H Pulz, G C Huete, S R Kleeb, J G Xavier, J L Catão-Dias, A T Nishiya, H Fukumasu, R F Strefezzi
Mast cell tumours (MCTs) are the most frequent canine round cell neoplasms and show variable biological behaviours with high metastatic and recurrence rates. The disease is treated surgically and wide margins are recommended. Adjuvant chemotherapy and radiotherapy used in this disease cause DNA damage in neoplastic cells, which is aimed to induce apoptotic cell death. Resisting cell death is a hallmark of cancer, which contributes to the development and progression of tumours. The aim of this study was to investigate the expression of the proteins involved in the apoptotic intrinsic pathway and to evaluate their potential use as prognostic markers for canine cutaneous MCTs...
June 13, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28596005/characterization-of-keratin-microparticles-from-feather-biomass-with-potent-antioxidant-and-anticancer-activities
#5
Swati Sharma, Arun Gupta, Syed Mohd S T Chik, Chua Geek Kee, Bhupendra M Mistry, Doo H Kim, Gaurav Sharma
In the present study chicken feathers were hydrolyzed by chemical treatment in alkaline conditions. The pH value of feather hydrolyzed solution was amended accordingly the iso-electric precipitation. Two types of keratin microparticles KM1, KM2 were synthesized under acidic conditions at 3.5 and 5.5pH respectively. The synthesized keratin microparticles possessed uniform and round surface by scanning electron microscopy (SEM). The thermal degradation of microparticles were examined by thermogravimetry (TGA)...
June 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28595579/omental-adipose-tissue-is-a-more-suitable-source-of-canine-mesenchymal-stem-cells
#6
Francisca Bahamondes, Estefania Flores, Gino Cattaneo, Flavia Bruna, Paulette Conget
BACKGROUND: Mesenchymal Stem Cells (MSCs) are a promising therapeutic tool in veterinary medicine. Currently the subcutaneous adipose tissue is the leading source of MSCs in dogs. MSCs derived from distinct fat depots have shown dissimilarities in their accessibility and therapeutic potential. The aims of our work were to determine the suitability of omental adipose tissue as a source of MSCs, according to sampling success, cell yield and paracrine properties of isolated cells, and compared to subcutaneous adipose tissue...
June 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28592719/effects-of-toceranib-phosphate-palladia-monotherapy-on-multidrug-resistant-lymphoma-in-dogs
#7
Hiroki Yamazaki, Naoki Miura, Yu-Chang Lai, Masashi Takahashi, Yuko Goto-Koshino, Momoi Yasuyuki, Munekazu Nakaichi, Hajime Tsujimoto, Asuka Setoguchi, Yasuyuki Endo
We examined whether multidrug resistant (MDR) canine lymphoma increases gene expression for platelet-derived growth factor receptor α (PDGFRα), vascular endothelial growth factor receptor 2 (VEGFR2), and c-KIT, and whether toceranib phosphate (TOC) has potential as a treatment for MDR canine lymphoma. The clinical data showed that PDGFRα expression was higher in canine subjects with MDR T-cell lymphoma than in those with untreated T-cell lymphoma, and that c-KIT expression was greater in subjects with T-cell lymphoma than in those with B-cell lymphoma...
June 6, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28579026/a-flow-cytometric-assessment-of-the-lymphocyte-immunophenotypes-in-dogs-naturally-infected-with-babesia-rossi
#8
Yolandi Rautenbach, Amelia Goddard, Peter N Thompson, Richard J Mellanby, Andrew L Leisewitz
Immunity to Babesia infection requires both innate and acquired responses, including cell mediated- and humoral responses. The aims of this study were to investigate the variation in selected peripheral blood lymphocyte phenotypes in dogs with virulent babesiosis at presentation and over time after treatment, and to determine whether these were correlated with the severity of clinical signs. Forty-four dogs naturally infected with B. rossi were studied and 5 healthy dogs were included as controls. Blood samples were collected from the jugular vein at admission, prior to any treatment, and at 24h and 48-72h...
July 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28574903/hsct-based-approaches-for-tolerance-induction-in-renal-transplant
#9
Anita Y Chhabra, Joseph Leventhal, Andrea R Merchak, Suzanne Ildstad
Renal transplantation has become the preferred treatment for end stage kidney failure. Although short-term graft survival has significantly improved as advances in immunosuppression have occurred, long term patient and graft survival have not. Approximately only 50% of renal transplant recipients are alive at 10 years due to the toxicities of immunosuppression and alloimmunity. Emerging research on cell-based therapies is opening a new door for patients to receive the organs they need without sacrificing quality of life and longevity because of drug based immunosuppression...
June 1, 2017: Transplantation
https://www.readbyqxmd.com/read/28566164/cervical-spinal-cord-and-motor-unit-pathology-in-a-canine-model-of-sod1-associated-amyotrophic-lateral-sclerosis
#10
Martin L Katz, Cheryl A Jensen, Jeffrey T Student, Gayle C Johnson, Joan R Coates
Development of effective treatments for amyotrophic lateral sclerosis (ALS) would be facilitated by identification of early events in the pathological cascade of disease progression. Degenerative myelopathy (DM), a naturally occurring disease in dogs, is quite similar to forms of ALS associated with SOD1 mutations and is likely to be a good model for these forms of the human disease. The sequence of histopathological changes that occur in DM was characterized by analyzing tissue samples obtained from affected dogs euthanized at various stages of disease progression...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28533336/a-coding-variant-in-the-gene-bardet-biedl-syndrome-4-bbs4-is-associated-with-a-novel-form-of-canine-progressive-retinal-atrophy
#11
Tracy Chew, Bianca Haase, Roslyn Bathgate, Cali E Willet, Maria K Kaukonen, Lisa J Mascord, Hannes T Lohi, Claire M Wade
Progressive retinal atrophy is a common cause of blindness in the dog and affects over 100 breeds. It is characterized by gradual vision loss that occurs due to the degeneration of photoreceptor cells in the retina. Similar to the human counterpart retinitis pigmentosa, the canine disorder is clinically and genetically heterogeneous and the underlying cause remains unknown for many cases. We use a positional candidate gene approach to identify putative variants in the Hungarian Puli breed using genotyping data of 14 family-based samples (CanineHD BeadChip array, Illumina) and whole genome sequencing data of two proband and two parental samples (Illumina HiSeq 2000)...
May 22, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28515135/not-all-antigens-are-created-equally-progress-challenges-and-lessons-associated-with-developing-a-vaccine-for-leishmaniasis
#12
Malcolm S Duthie, Steven G Reed
From experimental models and the analyses of patients, it is well documented that antigen-specific T cells are critical for protection against Leishmania infection. Effective vaccines require both targeting to the pathogen and an immune stimulant to induce maturation of appropriate immune responses. While a great number of antigens have been examined as vaccine candidates across various Leishmania species, few have advanced to human or canine clinical trials. With emphasis on antigen expression, in this minireview we discuss some the vaccine platforms that are currently being explored for the development of Leishmania vaccines...
May 17, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28508557/lopp-chemotherapy-as-a-first-line-treatment-for-dogs-with-t-cell-lymphoma
#13
P M Brown, S Tzannes, S Nguyen, J White, V Langova
BACKGROUND: The aim of this study was to describe the use of a lomustine (CCNU), vincristine, procarbazine and prednisolone (LOPP) protocol used for treatment of chemotherapy naive T-cell lymphoma patients and to describe the response rate, toxicity and disease-free interval compared historically to CHOP chemotherapy. MATERIALS AND METHODS: Retrospective case study of 31 dogs with naïve T-cell lymphoma treated with a lomustine (CCNU), vincristine, procarbazine and prednisolone (LOPP) protocol...
May 16, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28494924/loss-of-cd45-cell-surface-expression-in-canine-t-zone-lymphoma-results-from-reduced-gene-expression
#14
V Martini, M Cozzi, A Aricò, G Dalla Rovere, A Poggi, F Albonico, M Mortarino, E Ciusani, L Aresu, S Comazzi
Canine T-zone lymphoma (TZL) is a peculiar lymphoma subtype characterized by an indolent clinical course and aberrant CD45-negative phenotype, commonly recognized by flow cytometry (FC). Recent studies have described clinical presentation and behavior, but to date the mechanisms behind the loss of CD45 protein expression have never been investigated. The aims of this study were: 1) to confirm the absence of CD45 in canine TZL via the concomitant use of FC and immunohistochemistry with two different sources of antibody; and 2) to investigate the amount of CD45 transcript and the presence of CD45 gene in the neoplastic cells of dogs affected by TZL...
May 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28494700/invasive-front-grading-and-epithelial-mesenchymal-transition-in-canine-oral-and-cutaneous-squamous-cell-carcinomas
#15
E Nagamine, K Hirayama, K Matsuda, M Okamoto, T Ohmachi, K Uchida, T Kadosawa, H Taniyama
Oral and cutaneous tissues are the most frequent origin in canine squamous cell carcinoma (SSC). In SCC, changes in adhesion molecule expression and transition from epithelial to mesenchymal phenotype are thought to be important in development of invasive behavior of neoplastic cells at the leading front of the tumor. We therefore investigated histological invasive front grading and epithelial-mesenchymal transition (EMT) in both oral SCCs and cutaneous SCCs. EMT was assessed by evaluating immunohistochemical expression of E-cadherin, β-catenin, desmoglein, vimentin, and N-cadherin...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28491015/protocols-for-visually-guided-navigation-assessment-of-efficacy-of-retina-directed-cell-or-gene-therapy-in-canines
#16
Puya Aravand, Pavitra S Ramachandran, Ivan Schpylchak, Nicholas T Phelps, Sergei Nikonov, Jean Bennett
There has been marked progress in recent years in developing gene delivery approaches for the treatment of inherited blinding diseases. Many of the proof-of-concept studies have utilized rodent models of retinal degeneration. In those models, tests of visual function include a modified water maze swim test, optokinetic nystagmus, and light-dark activity assays. Test paradigms used in rodents can be difficult to replicate in large animals due to their size and awareness of non-visual aspects of the test system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28467670/high-cox-2-expression-in-canine-mast-cell-tumours-is-associated-with-proliferation-angiogenesis-and-decreased-overall-survival
#17
H Gregório, T Raposo, F L Queiroga, I Pires, L Pena, J Prada
COX-2 overexpression is associated with several hallmarks of carcinogenesis such as proliferation, angiogenesis, invasion and metastasis. Fifty cases of canine mast cell tumours (MCT) were retrospectively evaluated and submitted to immunohistochemistry for COX-2, CD31, Ki-67, MAC-387 and CD3. Furthermore its relationship with clinicopathological variables and overall survival (OS) was analysed. COX-2 intensity (P = 0.016), but not COX-2 extension nor score was associated with decreased OS and higher grades of malignancy according to Patnaik (P = 0...
November 7, 2016: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28464037/pressure-overload-induced-angiotensin-mediated-early-remodeling-in-mouse-heart
#18
Jeremy H Kim, Ya-Ping Jiang, Ira S Cohen, Richard Z Lin, Richard T Mathias
Our previous work on angiotensin II-mediated electrical-remodeling in canine left ventricle, in connection with a long history of other studies, suggested the hypothesis: increases in mechanical load induce autocrine secretion of angiotensin II (A2), which coherently regulates a coterie of membrane ion transporters in a manner that increases contractility. However, the relation between load and A2 secretion was correlative. We subsequently showed a similar or identical system was present in murine heart. To investigate whether the relation between mechanical load and A2-mediated electrical remodeling was causal, we employed transverse aortic constriction in mice to subject the left ventricle to pressure overload for short-term (1 to 2 days) or long-term (1 to 2 weeks) periods...
2017: PloS One
https://www.readbyqxmd.com/read/28392507/gene-and-protein-expression-of-a-soluble-form-of-ctla-4-in-a-healthy-dog
#19
Michihito Tagawa, Yuhei Yamamoto, Genya Shimbo, Aiko Iguchi, Xuenan Xuan, Mizuki Tomihari, Kazuro Miyahara
Cytotoxic T lymphocyte associated gene-4 (CTLA-4) is a costimulatory molecule, expressed on the surface of activated T cells that negatively regulates T cell activation. In humans, alternative splicing of the CTLA-4 gene generates two major isoforms of mRNA, and a soluble form of CTLA-4 (sCTLA-4) was detected in normal human serum. We describe alternatively spliced mRNA expressed in peripheral blood mononuclear cells obtained from a healthy dog lacking the transmembrane domain coded by exon 3 of the CTLA-4 gene...
May 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28386956/comparison-of-cellular-location-and-expression-of-plakophilin-2-in-epidermal-cells-from-nonlesional-atopic-skin-and-healthy-skin-in-german-shepherd-dogs
#20
Brita Ardesjö-Lundgren, Katarina Tengvall, Kerstin Bergvall, Fabiana H G Farias, Liya Wang, Åke Hedhammar, Kerstin Lindblad-Toh, Göran Andersson
BACKGROUND: Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease caused by interactions between genetic and environmental factors. Previously, a genome-wide significant risk locus on canine chromosome 27 for CAD was identified in German shepherd dogs (GSDs) and Plakophilin-2 (PKP2) was defined as the top candidate gene. PKP2 constitutes a crucial component of desmosomes and also is important in signalling, metabolic and transcriptional activities. OBJECTIVES: The main objective was to evaluate the role of PKP2 in CAD by investigating PKP2 expression and desmosome structure in nonlesional skin from CAD-affected (carrying the top GWAS SNP risk allele) and healthy GSDs...
April 6, 2017: Veterinary Dermatology
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