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Hiske J Brouwer, Marc C Den Heijer, Bernard P Paelinck, Philippe Debonnaire, Marc Vanderheyden, Caroline M Van De Heyning, Dina De Bock, Patrick Coussement, Georges Saad, Bert Ferdinande, Anne-Catherine Pouleur, Marc J Claeys
Aims: The effect of MitraClip implantation on left ventricular (LV) remodelling has been shown to be highly variable. The present study wants to assess patterns of LV remodelling and its relationship with outcome. Methods and results: Serial echocardiography before, 1 and 6 months after MitraClip implantation was performed in 79 pts with severe mitral regurgitation (MR) (age 74 ± 10 years, New York Heart Association III/IV 80%, LV ejection fraction 38 ± 13%, logistic EuroSCORE 21 ± 15, and functional MR 81%)...
July 11, 2018: European Heart Journal Cardiovascular Imaging
Yasuyo Takeuchi, Hiroki Sakamoto, Genichi Sakaguchi, Toshio Shimada
No abstract text is available yet for this article.
July 13, 2018: Journal of Echocardiography
Tanja Vajen, Rory R Koenen, Isabella Werner, Mareike Staudt, Delia Projahn, Adelina Curaj, Tolga Taha Sönmez, Sakine Simsekyilmaz, David Schumacher, Julia Möllmann, Tilman M Hackeng, Philipp von Hundelshausen, Christian Weber, Elisa A Liehn
Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic interaction of CCL5 and CXCL4 in the progression of atherosclerosis. A specifically designed compound (MKEY) to block this CCL5-CXCR4 interaction is investigated as a potential therapeutic in a model of myocardial ischemia/reperfusion (I/R) damage. 8 week-old male C57BL/6 mice were intravenously treated with MKEY or scrambled control (sMKEY) from 1 day before, until up to 7 days after I/R...
July 13, 2018: Scientific Reports
Manasawee Indrabhinduwat, Maria C Arciniegas Calle, Joseph P Colgan, Hector R Villarraga
SummaryThirty-seven-year-old male presented with cough, dyspnea, significant weight loss (20 kg) and subacute fever for the past 2 months. Physical examination revealed inspiratory and expiratory wheezing bilaterally. A normal S1, S2 and a 3/6 systolic ejection murmur at the left upper parasternal border with respiratory variation were found during cardiac auscultation. Kidney and bone marrow biopsy reported a high-grade B-cell lymphoma. Echocardiography and cardiac CT findings consisted of multiple intracardiac masses affecting the right ventricular (RV) outflow track, RV apex, medial portion of the right atrium and posterior left atrium, as well as mild impairment of the RV systolic function...
September 2018: Echo Research and Practice
Salma El Batti, Iannis Ben Abdallah, Edouard Dufetelle, Pierre Julia, Philippe Menasche, Jean-Marc Alsac
OBJECTIVE/BACKGROUND: To evaluate the experimental feasibility of endovascular fenestration using specific endovascular scissor prototypes in an ovine model of acute aortic dissection (AD). METHODS: A previously described endovascular technique was used to create a model of acute type B AD in sheep. Endovascular fenestrations using either endovascular scissor prototypes or a long sheath were compared. Four prototypes of endovascular fenestration scissors were evaluated...
July 10, 2018: European Journal of Vascular and Endovascular Surgery
Katsuhide Maeda, Ingela Schnittger, Daniel J Murphy, Jennifer A Tremmel, Jack H Boyd, Lynn Peng, Kozo Okada, Vedant S Pargaonkar, Frank L Hanley, Robert Scott Mitchell, Ian S Rogers
BACKGROUND: Although myocardial bridges (MBs) are traditionally regarded as incidental findings, it has been reported that adult patients with symptomatic MBs refractory to medical therapy benefit from unroofing. However, there is limited literature in the pediatric population. The aim of our study was to evaluate the indications and outcomes for unroofing in pediatric patients. METHODS: We retrospectively reviewed all pediatric patients with MB in our institution who underwent surgical relief...
June 9, 2018: Journal of Thoracic and Cardiovascular Surgery
Mengyun Yao, Yuman Li, Shima Ibrahim Ali, Mingxing Xie, Qing Lv
This case series describes echocardiographic and computed tomography angiographic (CTA) characteristics, clinical features, diagnosis, and treatment in 15 patients of Pulmonary artery sling (PAS). Echocardiography is effective in diagnosing PAS, when the main pulmonary artery extends to the right pulmonary artery directly with the left pulmonary artery arising from the right pulmonary artery. CTA, clearly demonstrating the position and extent of trachea compression, the anatomy of PAS and the spatial relationships among the PAS, trachea and the esophagus, is necessary for the final diagnosis...
July 13, 2018: Echocardiography
Yoshihito Saijo, Hirotsugu Yamada, Kenya Kusunose, Mika Bando, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Tomomi Matsuura, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
AIM: To improve the prognosis of patients with heart failure, risk stratification in their early stage is important. We assessed whether the change in transmitral flow (TMF) velocity pattern during preload augmentation can predict future hemodynamic worsening in early-stage heart failure patients with impaired relaxation TMF pattern. METHODS: We designed a prospective cohort study that included 155 consecutive patients with impaired relaxation (IR) pattern at rest...
July 13, 2018: Echocardiography
Niraj Nirmal Pandey, Arun Sharma, Priya Jagia
Abnormal embryological development of the pulmonary veins can manifest as either partial or total anomalous drainage into the systemic venous circulation. Echocardiography does not provide adequate information in all cases as the optimal visualization of anomalous structures is limited by the availability of acoustic window; also it is highly operator dependent. However, multidetector computed tomography (MDCT) angiography, with its multiplanar reformatting & volume rendering techniques, offers precise information about the 3D anatomy and spatial relationships of the cardiovascular structures...
July 13, 2018: British Journal of Radiology
Kristian H Mortensen, Oliver Tann
Cardiovascular computed tomography (CCT) is an important imaging modality in congenital and acquired paediatric heart disease. Technological advances have resulted in marked improvements in spatial and temporal resolution with a concomitant increase in speed of data acquisition and a decrease in radiation doses. This has elevated CCT from being sparingly used to an essential diagnostic tool in the daily multimodality imaging practice alongside echocardiography, cardiovascular magnetic resonance and invasive angiography...
July 13, 2018: British Journal of Radiology
Aibek E Mirrakhimov, Michael E Jesinger, Taha Ayach, Adam Gray
No abstract text is available yet for this article.
July 2018: Cleveland Clinic Journal of Medicine
William M Torres, Julia Jacobs, Heather Doviak, Shayne C Barlow, Michael R Zile, Tarek Shazly, Francis G Spinale
The aim of this study was to quantify regional changes in myocardial biomechanics in a large animal model of MI. Post-MI remodeling has distinct regional effects throughout the LV myocardium. Regional quantification of LV biomechanical behavior could help explain changes in global function and thus advance clinical assessment of post-MI remodeling. The present study is based on a porcine MI model to characterize LV biomechanics over 28 days post-MI via speckle-tracking echocardiography (STE). Regional myocardial strain and strain rate were recorded in the circumferential, radial, and longitudinal directions at baseline and at three, 14, and 28 days post-MI...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Dimosthenis Giamouridis, Mei Hua Gao, N Chin Lai, Zhen Tan, Young Chul Kim, Tracy Guo, Atsushi Miyanohara, Matthijs W Blankesteijn, Erik A L Biessen, H Kirk Hammond
BACKGROUND: Peptide infusions of the corticotropin releasing factor family, including urocortin 2, stresscopin, and urocortin 3 (UCn3) have favorable acute effects in clinical heart failure (HF), but their short half-lives make them unsuited for chronic therapy. Here we ask whether UCn3 gene transfer, which provides sustained elevation of plasma UCn3 levels, increases function of the failing heart. METHODS: HF was induced by transmural left ventricular (LV) cryoinjury in mice...
July 13, 2018: Human Gene Therapy
Min-Jung Cho, Ji-Won Lee, JeSang Lee, Yong Beom Shin
Although progressive cardiac dysfunction is the leading cause of death in patients with Duchenne muscular dystrophy (DMD), their cardiac function measured by conventional echocardiography has been generally interpreted as normal at a young age. We aimed to determine whether two-dimensional speckle tracking echocardiography (STE) or tissue Doppler imaging (TDI) could be used for early identification and detection of cardiac dysfunction in young patients with DMD. Thirteen pediatric patients (mean age, 9.69 ± 2...
July 12, 2018: Pediatric Cardiology
Love Ahlström, Michal Odermarsky, Torsten Malm, Jens Johansson Ramgren, Petru Liuba
In transposition of the great arteries (TGA), certain coronary patterns have been associated with major adverse events early after the arterial switch operation (ASO). We sought to determine the impact of preoperative echocardiographic (ECHO) diagnosis on the intra- and postoperative morbidity. All patients with TGA born between June 2001 and June 2017 and who underwent ASO were reviewed. Data on presumed coronary anatomy (CA) preoperatively were obtained from the preoperative ECHO report. Intraoperative CA was categorized according to Yacoub classification...
July 12, 2018: Pediatric Cardiology
Paweł Latacz, Marian Simka, Pawel Brzegowy, Wojciech Serednicki, Ewa Konduracka, Wojciech Mrowiecki, Agnieszka Słowik, Bartłomiej Łasocha, Tomasz Mrowiecki, Tadeusz Popiela
Introduction: Intravenous thrombolysis is the treatment of choice in patients presenting with high- and intermediate-risk pulmonary embolism. The role of percutaneous mechanical pulmonary thrombectomy (PMPT) is not fully established, although selected patients can be managed with this method. Aim: This open-label single-centre prospective pilot study was aimed at assessing the feasibility of PMPT for the treatment of severe pulmonary embolism in a Polish hospital...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Petra Nijst, Mikhail Olinevich, Petra Hilkens, Pieter Martens, Matthias Dupont, W H Wilson Tang, Ivo Lambrichts, Jean-Paul Noben, Wilfried Mullens
BACKGROUND: Large networks of interstitial glycosaminoglycans help to regulate water and electrolyte homeostasis. The relation between dermal interstitial alterations and occurrence of edema in heart failure patients with reduced ejection fraction (HFrEF) is unknown. We hypothesize that in HFrEF patients (1) interstitial glycosaminoglycan density is increased, (2) changes in the interstitial glycosaminoglycan network are associated with interstitial fluid accumulation, and (3) there is a link between the interstitial glycosaminoglycan network and the renin-angiotensin-aldosterone system...
July 2018: Circulation. Heart Failure
Tarique A Musa, Thomas A Treibel, Vassiliou S Vassiliou, Gabriella Captur, Anvesha Singh, Calvin Chin, Laura E Dobson, Silvia Pica, Margaret Loudon, Tamir Malley, Marzia Rigolli, James R J Foley, Petra Bijsterveld, Graham R Law, Marc Dweck, Saul G Myerson, Gerry P McCann, Sanjay K Prasad, James C Moon, John P Greenwood
Background -Aortic valve replacement (AVR) for aortic stenosis (AS) is timed primarily on the development of symptoms; but late surgery can result in irreversible myocardial dysfunction and additional risk. This study aimed to determine whether presence of focal myocardial scar pre-operatively was associated with long-term mortality. Methods -In a longitudinal observational outcome study, survival analysis was performed in patients with severe AS listed for valve intervention at six UK cardiothoracic centers...
July 12, 2018: Circulation
Sílvia Aguiar Rosa, Ana Figueiredo Agapito, Marta António, Lídia de Sousa, José Alberto Oliveira, Sérgio Laranjo, Susana Martins, Nuno Jalles Tavares, Fátima F Pinto, Rui Cruz Ferreira
Uhl's anomaly is a rare disease secondary to the selective but uncontrolled apoptosis of right ventricular myocytes during the perinatal period, following complete cardiac development. This explains the absence of the right ventricular myocardium and the direct apposition of endocardium to epicardium without a myocardial layer in between, resulting in right ventricular failure. This paper describes a case of Uhl's disease with an uncommon presentation. A 28-year-old man was admitted with dyspnea and cyanosis...
July 9, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
M Inmaculada Poveda García, M Dolores Del Pino Y Pino, Raquel Alarcón Rodriguez, Cristian Rodelo-Haad, Tesifón Parrón Carreño
INTRODUCTION: We aimed to assess the effectiveness of ambulatory blood pressure monitoring (ABPM) and subclinical target organ damage parameters for diagnosis of resistant hypertension (RH). METHODS: We assessed demographic and anthropometric variables, the incidence of cardiovascular events and subclinical target organ damage (n=112). We also studied the relationship between these variables and the ABPM results. RESULTS: Of the 112 patients referred from primary care with a diagnosis of RH, 69 (61...
July 9, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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