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Echocardiography

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https://www.readbyqxmd.com/read/28944999/systemic-redistribution-of-the-intramyocardially-injected-mesenchymal-stem-cells-by-repeated-remote-ischaemic-post-conditioning
#1
Qin Jiang, Tao Yu, Keli Huang, Hao Zhang, Zhe Zheng, Shengshou Hu
We investigated the effect of repeated remote ischaemic post-conditioning (RIPoC) on the organ distribution of the intramyocardially injected MSCs in rat myocardial ischemia model. Myocardial ischemia of adult female Sprague-Dawley rats was induced by 30-min. obstruction of the left anterior descending coronary artery. Repeated RIPoC was induced after ischemia with three cycles of 5-min. occlusion and reperfusion of the limb with the frequency of half a day, 1 or 2 days, respectively. Compared with that by single RIPoC, repeated RIPoC transiently reduced oxidative stress, lipid peroxidation and inflammation in ischaemic myocardium; the gene expression of stromal cell-derived factor-1 alpha (SDF-1α) was consistently induced by repeated RIPoC procedures...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944177/isolated-septal-myectomy-for-hypertrophic-obstructive-cardiomyopathy-an-update-on-the-toronto-general-hospital-experience
#2
Rachel D Vanderlaan, Anna Woo, Anthony Ralph-Edwards
BACKGROUND: Isolated septal myectomy is considered the gold standard for refractory left ventricular outflow tract (LVOT) obstruction at centers with dedicated hypertrophic obstructive cardiomyopathy (HOCM) surgeons. In this paper, we provide an update on the Toronto General Hospital (TGH) experience for isolated septal myectomy and comment on the safety and efficacy of myectomy in patients with thin basal septal thickness at our institution. METHODS: We retrospectively reviewed all patients undergoing surgical myectomy at our institution from January 2012 to August 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944174/hypertrophic-obstructive-cardiomyopathy-the-leipzig-experience
#3
Jawad Khalil, Michael Kuehl, Pirose Davierwala, Friedrich Wilhelm Mohr, Martin Misfeld
BACKGROUND: Management of hypertrophic obstructive cardiomyopathy (HOCM) has evolved considerably over the last fifty years, and includes medical treatment as well as septal myectomy (SM) to relief symptoms caused by left ventricular outflow tract obstruction (LVOTO). We report the Leipzig Heart Center experience in the surgical management of patients with HOCM. METHODS: We collected data from all patient treated surgically with a myectomy for LVOTO in patients with HOCM between 1997 and 2016...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28944171/current-state-of-the-art-and-future-of-myectomy
#4
REVIEW
Magdi H Yacoub, Ahmed Afifi, Hesham Saad, Heba Aguib, Ahmed ElGuindy
Surgical relief of left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) requires more than septal myectomy. The procedure is currently the gold standard for all symptomatic HCM patients except those with comorbidities. The operation requires an individualized approach to restore the sophisticated functions of the left ventricular outflow tract (LVOT) without injury to the surrounding vital structures. The procedure should be tailored to deal with all the varied components of the obstruction including fibrous trigones, accessory tissues, and papillary muscle fusion...
July 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28943564/resolution-of-left-atrial-appendage-thrombus-with-apixaban-in-a-patient-with-heart-failure
#5
Takenori Okada, Yuji Takaekou, Naomi Idei, Norihiko Ohashi, Shunichi Kaseda
The effect of non-vitamin K antagonist oral anticoagulants on left atrial appendage (LAA) thrombus has not been fully elucidated. There are a few reports showing resolution of LAA thrombus with apixaban. An 84-year-old woman was admitted to our hospital due to acute exacerbation of chronic heart failure and marked tachycardia with atrial fibrillation. She had permanent atrial fibrillation and was treated with warfarin; however, transthoracic echocardiography revealed a non-mobile thrombus in the LAA. Therefore, we switched warfarin to apixaban at a dose of 5 mg/day...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28943533/incidence-and-significance-of-spontaneous-st-segment-re-elevation-after-reperfused-anterior-acute-myocardial-infarction%C3%A3-relationship-with-infarct-size-adverse-remodeling-and-events-at-1-year
#6
Léo Cuenin, Sophie Lamoureux, Mathieu Schaaf, Thomas Bochaton, Jean-Pierre Monassier, Marc J Claeys, Gilles Rioufol, Gérard Finet, David Garcia-Dorado, Denis Angoulvant, Meyer Elbaz, Nicolas Delarche, Pierre Coste, Marc Metge, Thibault Perret, Pascal Motreff, Eric Bonnefoy-Cudraz, Gérald Vanzetto, Olivier Morel, Inesse Boussaha, Michel Ovize, Nathan Mewton
BACKGROUND: Up to 25% of patients with ST elevation myocardial infarction (STEMI) have ST segment re-elevation after initial regression post-reperfusion and there are few data regarding its prognostic significance.Methods and Results:A standard 12-lead electrocardiogram (ECG) was recorded in 662 patients with anterior STEMI referred for primary percutaneous coronary intervention (PPCI). ECGs were recorded 60-90 min after PPCI and at discharge. ST segment re-elevation was defined as a ≥0...
September 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943264/could-anticoagulation-avoid-bioprosthesis-subclinical-thrombosis-in-patients-undergoing-transcatheter-aortic-valve-replacement
#7
François Huchet, Vincent Letocart, Patrice Guerin, Caroline Cueff, Julie Roy-Giocosa, Béatrice Guyomarch-Delasalle, Philippe Jaafar, Thibaut Manigold
BACKGROUND: Despite a lack of clear evidence, current European guidelines recommend antiplatelet therapy after transcatheter aortic valve replacement (TAVR). Recent investigations suggest that bioprosthesis thrombosis after TAVR is not uncommon and may be prevented by anticoagulation, but not by antiplatelet therapy. AIMS: The study objective was to assess the impact of the antithrombotic regimen on post-TAVR early haemodynamics. METHODS: Patients eligible for TAVR with an Edwards SAPIEN 3 valve were included in this prospective observational study...
September 21, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28943125/electrocardiographic-echocardiographic-and-left-atrial-strain-imaging-features-of-a-dog-with-atrial-flutter-and-third-degree-atrioventricular-block
#8
M Baron Toaldo, G Romito, M Cipone, A Diana, M Tursi
A 14-year-old American Staffordshire terrier was presented for episodes of exercise-induced syncope. At admission, atrial flutter coupled to third-degree atrioventricular block was diagnosed electrocardiographically. On the second day of hospitalization, surface electrocardiogram revealed spontaneous conversion to sinus rhythm with persistence of atrioventricular block. Complete transthoracic echocardiograms were performed after each electrocardiographic examination. The combined use of conventional echocardiography with tissue Doppler imaging-based modalities allowed to investigate the atrial electromechanical correlation and function during typical atrial flutter and after its resolution...
September 21, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28942941/iron-laboratory-studies-in-pediatric-patients-with-heart-failure-from-dilated-cardiomyopathy
#9
David Higgins, Jessica Otero, Christa Jefferis Kirk, Jennifer Pak, Neal Jorgensen, Mariska Kemna, Erin Albers, Borah Hong, Joshua Friedland-Little, Yuk Law
Iron deficiency (FeD), with or without anemia, in adults with heart failure (HF) is associated with poor outcomes, which can be improved with replacement therapy. A similar therapeutic opportunity may exist for children; however, iron laboratory measurements and FeD have not been described in pediatric patients with HF. A single-center, retrospective study was conducted on 28 patients <21 years old with a diagnosis of dilated cardiomyopathy and HF who had iron laboratories (serum iron, iron saturation, and ferritin) performed...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28942610/impact-of-acute-left-ventricular-apical-thrombus-on-cardioversion-for-atrial-fibrillation
#10
Vaibhav R Vaidya, Suartcha Prueksaritanond, John P Bois, Abhinav Nadipalli, Daniel D Borgeson, Rowlens M Melduni
Among patients undergoing cardioversion for atrial fibrillation, the presence of left ventricular thrombus is a relatively uncommon and challenging clinical dilemma. While left atrial appendage thrombus is a contraindication to cardioversion, there is paucity of data regarding the safety of cardioversion in with the presence of left ventricular apical thrombus. Also, thrombus characteristics such as protrusion and mobility on echocardiography are known risk factors for systemic embolism. In this article, we present a case highlighting the management of atrial fibrillation in the setting of left ventricular dysfunction, acute heart failure, and echocardiographic evidence of acute left ventricular apical thrombus...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28942609/custom-extracellular-matrix-cylinder-mitral-valve-in-a-pediatric-patient
#11
Clifford L Cua, Pace Johnston, Jill Harmon, Kathryn Shelton, Patrick I McConnell
Mitral valve construction using extracellular matrix (ECM) is a relatively new procedure. In this case, a 15-month-old boy with a history of severe mitral valve regurgitation secondary to endocarditis underwent mitral valve surgery. Mitral valve repair was not possible, and thus, a 17 mm extracellular matrix cylinder valve (ECM-CV) was constructed for valve replacement. The ECM-CV is clearly imaged using echocardiography, especially three-dimensional imaging, that helped define valve function. As the use of ECM for valve construction increases, echocardiography will play an essential role in evaluating the function and mechanics of these novel valves...
September 24, 2017: Echocardiography
https://www.readbyqxmd.com/read/28942444/peripheral-endothelial-function-and-coronary-flow-velocity-reserve-are-not-associated-in-women-with-angina-and-no-obstructive-coronary-artery-disease-the-ipower-study
#12
Kristoffer Flintholm Raft, Daria Frestad, Marie Mide Michelsen, Hannah Elena Suhrs, Anna Bay Rask, Malin Nilsson, Thomas Steffen Hermann, Eva Prescott
PURPOSE: We investigated whether impaired flow-mediated dilation (FMD) and plasma biomarkers reflecting endothelial dysfunction are associated with coronary microvascular dysfunction (CMD) in women with angina and no obstructive coronary artery disease (CAD). METHODS: Patients (n = 194) were randomly selected women with angina pectoris and no obstructive CAD (<50% stenosis). A reference population of asymptomatic women without CAD (n = 25) was included. We measured FMD in the brachial artery by high-resolution ultrasound...
September 23, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28942390/imaging-for-structural-heart-procedures-focus-on-computed-tomography
#13
John Mooney, Stephanie L Sellers, Mickaël Ohana, João L Cavalcante, Chesnal D Arepalli, Rominder Grover, Ung Kim, Kapilan Selvakumar, Philipp Blanke, Jonathon A Leipsic
The success and continued rapid clinical integration of transcatheter valve technologies relies on imaging modalities to guide safe and effective device deployment. In particular, cardiac imaging, using both echocardiography and CT, is an integral resource for the multidisciplinary team. These modalities can provide valuable insight for the proceduralist at each stage of transcatheter-based valve insertion, as they can be used reliably to define the anatomy of interest and its relationship to surrounding structures, determine accurate device sizing, assess patients for valve-in-valve procedures, and screen for adverse features or procedural contraindications...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942269/echocardiographic-strain-analysis-for-the-early-detection-of-myocardial-structural-abnormality-and-initiation-of-drug-therapy-in-a-mouse-model-of-dilated-cardiomyopathy
#14
Minjuan Zheng, Feng Pan, Ying Liu, Zhenzhou Li, Xiaodong Zhou, Xin Meng, Liwen Liu, Shuping Ge
This study aimed to evaluate the role of echocardiography-based strain analysis in the early diagnosis and guidance for management of dilated cardiomyopathy (DCM). Muscular dystrophy mice (which spontaneously develop DCM) and control (C57 BL/6 J) mice were sequentially evaluated by ultrasound biomicroscopy, conventional left ventricle (LV) measurement, two-dimensional (2-D) strain analysis and myocardial histologic analysis for 12 consecutive months. Significant alternation of LV remodeling and dysfunction could be detected by conventional echocardiography after 9 mo, by strain analysis after 5 mo and by histologic analysis after 4 mo...
September 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28941985/stimulation-of-ganglionated-plexus-attenuates-cardiac-neural-remodeling-and-heart-failure-progression-in-a-canine-model-of-acute-heart-failure-post-myocardial-infarction
#15
Da Luo, Huihui Hu, Zhiliang Qin, Shan Liu, Xiaomei Yu, Ruisong Ma, Wenbo He, Jing Xie, Zhibing Lu, Bo He, Hong Jiang
BACKGROUND: Heart failure (HF) is associated with autonomic dysfunction. Vagus nerve stimulation has been shown to improve cardiac function both in HF patients and animal models of HF. The purpose of this present study is to investigate the effects of ganglionated plexus stimulation (GPS) on HF progression and autonomic remodeling in a canine model of acute HF post-myocardial infarction. METHODS AND RESULTS: Eighteen adult mongrel male dogs were randomized into the control (n=8) and GPS (n=10) groups...
September 18, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28941626/deletion-of-protein-tyrosine-phosphatase-1b-obliterates-endoplasmic-reticulum-stress-induced-myocardial-dysfunction-through-regulation-of-autophagy
#16
Shuyi Wang, Xiyao Chen, Sreejayan Nair, Dongdong Sun, Xiaoming Wang, Jun Ren
Endoplasmic reticulum (ER) stress has been demonstrated to prompt various cardiovascular risks although the underlying mechanism remains elusive. Protein tyrosine phosphatase-1B (PTP1B) serves as an essential negative regulator for insulin signaling. This study examined the role of PTP1B in ER stress-induced myocardial anomalies and underlying mechanism involved with a focus on autophagy. WT and PTP1B knockout mice were subjected to the ER stress inducer tunicamycin (1mg/kg). Cardiac function was evaluated with echocardiography and an Ion-Optix MyoCam system...
September 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28941596/robust-suppression-of-cardiac-energy-catabolism-with-marked-accumulation-of-energy-substrates-during-lipopolysaccharide-induced-cardiac-dysfunction-in-mice
#17
Yogi Umbarawan, Mas Rizky A A Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hiroaki Sunaga, Hiroki Matsui, Takako Hishiki, Tomomi Matsuura, Norimichi Koitabashi, Masaru Obokata, Hirofumi Hanaoka, Anwarul Haque, Fumio Kunimoto, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Iso
BACKGROUND: Myocardial contractile dysfunction in sepsis has been attributed mainly to increased inflammatory cytokines, insulin resistance, and impaired oxidative phosphorylation of fatty acids (FAs). However, precise molecular mechanisms underlying the cardiac dysfunction in sepsis remain to be determined. We previously reported major shift in myocardial energy substrates from FAs to glucose, and increased hepatic ketogenesis in mice lacking fatty acid-binding protein 4 (FABP4) and FABP5 (DKO)...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28940843/comparison-of-transcatheter-aortic-valve-replacement-risk-score-against-currently-accepted-surgical-risk-models-as-predictors-of-30-day-mortality-in-transcatheter-aortic-valve-replacement
#18
Yan Yatsynovich, Himad Khattak, Mohammed Ali, Brian Schwartz, Stella Pak, Tian Chen
OBJECTIVES: Aim of the study was to assess the predictive capability of Transcatheter Aortic Valve Replacement Risk Score (TAVR-RS) in comparison with Society of Thoracic Surgeon-Predicted Risk of Mortality (STS PROM) and European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) on 30-day mortality following TAVR. BACKGROUND: With exponentially increasing use of TAVR, a risk stratification model to accurately predict mortality risks in patients undergoing TAVR is urgently warranted...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28940794/percutaneous-pulmonary-valve-implantation-for-reconstruction-of-a-patch-repaired-right-ventricular-outflow-tract
#19
Anoosh Esmaeili, Simone Bollmann, Markus Khalil, Roberta De Rosa, Stephan Fichtlscherer, Hakan Akintuerk, Dietmar Schranz
Percutaneous pulmonary valve implantation (PPVI) is nowadays an accepted treatment option to repair post-surgical conduit dysfunction of the right ventricular outflow tract (RVOT). In addition, many patients need a pulmonary valve to reconstruct a hemodynamically incompetent native or conduit free outflow tract. Based on our experience with percutaneous stent-valve placement in a cohort of 125 patients, we report here transvenous reconstruction of a conduit-free, patch repaired outflow tract by utilizing balloon-expandable stent-valves in 23 patients with a median age of 22 years (5-60 years)...
September 20, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28940686/median-effective-dose-of-intranasal-dexmedetomidine-sedation-for-transthoracic-echocardiography-in-pediatric-patients-with-noncyanotic-congenital-heart-disease-an-up-and-down-sequential-allocation-trial
#20
Qing Yu, Yang Liu, Mang Sun, Jing Zhang, Yan Zhao, Fengzhi Liu, Shangyingying Li, Shengfen Tu
BACKGROUND: Intranasal dexmedetomidine can provide adequate sedation during short procedures. However, previous literature investigating the single-dose use of intranasal dexmedetomidine for sedation during transthoracic echocardiography in younger children is scarce, and the effects of age on sedation with intranasal dexmedetomidine remain controversial. OBJECTIVE: This study was to determine the 50% effective dose and estimate the 95% effective dose of single-dose intranasal dexmedetomidine to induce sedation in pediatric patients with noncyanotic congenital heart disease, and also determine the effect of age on the dose required for sedation...
September 20, 2017: Paediatric Anaesthesia
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