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https://www.readbyqxmd.com/read/28407788/absence-of-neurological-abnormalities-in-mice-homozygous-for-the-polr3a-g672e-hypomyelinating-leukodystrophy-mutation
#1
Karine Choquet, Sharon Yang, Robyn D Moir, Diane Forget, Roxanne Larivière, Annie Bouchard, Christian Poitras, Nicolas Sgarioto, Marie-Josée Dicaire, Forough Noohi, Timothy E Kennedy, Joseph Rochford, Geneviève Bernard, Martin Teichmann, Benoit Coulombe, Ian M Willis, Claudia L Kleinman, Bernard Brais
Recessive mutations in the ubiquitously expressed POLR3A gene cause one of the most frequent forms of childhood-onset hypomyelinating leukodystrophy (HLD): POLR3-HLD. POLR3A encodes the largest subunit of RNA Polymerase III (Pol III), which is responsible for the transcription of transfer RNAs (tRNAs) and a large array of other small non-coding RNAs. In order to study the central nervous system pathophysiology of the disease, we introduced the French Canadian founder Polr3a mutation c.2015G > A (p.G672E) in mice, generating homozygous knock-in (KI/KI) as well as compound heterozygous mice for one Polr3a KI and one null allele (KI/KO)...
April 13, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28394563/unclonable-security-codes-designed-from-multicolor-luminescent-lanthanide-doped-y2o3-nanorods-for-anticounterfeiting
#2
Pawan Kumar, Kanika Nagpal, Bipin Kumar Gupta
The duplicity of important documents has emerged as a serious problem worldwide. Therefore, many efforts have been devoted to developing easy and fast anticounterfeiting techniques with multicolor emission. Herein, we report the synthesis of multicolor luminescent lanthanide-doped Y2O3 nanorods by hydrothermal method and their usability in designing of unclonable security codes for anticounterfeiting applications. The spectroscopic features of nanorods are probed by photoluminescence spectroscopy. The Y2O3:Eu(3+), Y2O3:Tb(3+), and Y2O3:Ce(3+) nanorods emit hypersensitive red (at 611 nm), strong green (at 541 nm), and bright blue (at 438 nm) emissions at 254, 305, and 381 nm, respectively...
April 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28384737/annals-graphic-medicine-code-blue
#3
Michael Natter
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28383180/two-tier-screening-platform-for-directed-evolution-of-aminoacyl-trna-synthetases-with-enhanced-stop-codon-suppression-efficiency
#4
Andrew E Owens, Katherine T Grasso, Christine A Ziegler, Rudi Fasan
Genetic code expansion via amber stop suppression provides a powerful tool for introducing non-proteinogenic functionalities into proteins for a broad range of applications. Here, we report the implementation of a versatile platform for the development of engineered aminoacyl-tRNA synthetases with enhanced efficiency in mediating ncAA incorporation via amber stop codon suppression. This system integrates a white/blue colony screen with a plate-based colorimetric assay, thereby combining high-throughput capabilities with reliable and quantitative measurement of AARS-dependent ncAA incorporation efficiency...
April 6, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28380952/single-exposure-quantitative-phase-imaging-in-color-coded-led-microscopy
#5
Wonchan Lee, Daeseong Jung, Suho Ryu, Chulmin Joo
We demonstrate single-shot quantitative phase imaging (QPI) in a platform of color-coded LED microscopy (cLEDscope). The light source in a conventional microscope is replaced by a circular LED pattern that is trisected into subregions with equal area, assigned to red, green, and blue colors. Image acquisition with a color image sensor and subsequent computation based on weak object transfer functions allow for the QPI of a transparent specimen. We also provide a correction method for color-leakage, which may be encountered in implementing our method with consumer-grade LEDs and image sensors...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28370709/where-does-the-albumin-go-human-albumin-solution-usage-following-the-implementation-of-a-demand-management-programme
#6
M S Yazdani, A Retter, T Maggs, P Li, M G Robson, C Reid, P Holmes, T Garood, S E Robinson
OBJECTIVE: To outline the Guy's and St Thomas' NHS Foundation Trust (GSTFT) and Evelina London Children's Hospital (ELCH) demand management plan for human albumin solution (HAS) and usage. BACKGROUND: There is no UK-wide guidance governing the use of HAS. A severe shortage in 2015 prompted a Trust demand management programme. Indications were categorised according to locally agreed colour code and ASFA categories. METHODS: Following the implementation of the demand management programme, a 6-month audit of HAS usage was completed...
April 3, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28368926/basal-cell-carcinoma-with-matrical-differentiation-clinicopathologic-immunohistochemical-and-molecular-biological-study-of-22-cases
#7
Liubov Kyrpychova, Richard A Carr, Petr Martinek, Tomas Vanecek, Raul Perret, Magdalena Chottová-Dvořáková, Michal Zamecnik, Ladislav Hadravsky, Michal Michal, Dmitry V Kazakov
Basal cell carcinoma (BCC) with matrical differentiation is a fairly rare neoplasm, with about 30 cases documented mainly as isolated case reports. We studied a series of this neoplasm, including cases with an atypical matrical component, a hitherto unreported feature. Lesions coded as BCC with matrical differentiation were reviewed; 22 cases were included. Immunohistochemical studies were performed using antibodies against BerEp4, β-catenin, and epithelial membrane antigen (EMA). Molecular genetic studies using Ion AmpliSeq Cancer Hotspot Panel v2 by massively parallel sequencing on Ion Torrent PGM were performed in 2 cases with an atypical matrical component (1 was previously subjected to microdissection to sample the matrical and BCC areas separately)...
March 31, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28359242/small-molecule-inhibitors-of-epigenetic-mutations-as-compelling-drug-targets-for-myelodysplastic-syndromes
#8
Bani Bandana Ganguly
BACKGROUND: Involvement of mutations in epigenetic mechanism in development of heterogeneous MDS and its evolution to AML has been understood with at least one mutation and median of 2-3 mutations of the landscapes of driver mutations in ~40 genes described >90% MDS patients. Exclusivity and cooperating effects of mutations have directed therapeutic implementation with hypomethylating agents and identified a number of first-in-class small molecules as inhibitors of mutational expression...
March 30, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28358321/the-influence-of-tetrodotoxin-ttx-on-the-distribution-and-chemical-coding-of-caudal-mesenteric-ganglion-camg-neurons-supplying-the-porcine-urinary-bladder
#9
Ewa Lepiarczyk, Agnieszka Bossowska, Jerzy Kaleczyc, Marta Majewska, Sławomir Gonkowski, Mariusz Majewski
The treatment of micturition disorders creates a serious problem for urologists. Recently, new therapeutic agents, such as neurotoxins, are being considered for the therapy of urological patients. The present study investigated the chemical coding of caudal mesenteric ganglion (CaMG) neurons supplying the porcine urinary bladder after intravesical instillation of tetrodotoxin (TTX). The CaMG neurons were visualized with retrograde tracer Fast blue (FB) and their chemical profile was disclosed with double-labeling immunohistochemistry using antibodies against tyrosine hydroxylase (TH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), somatostatin (SOM), calbindin (CB), galanin (GAL) and neuronal nitric oxide synthase (nNOS)...
March 30, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28352646/-blue-voltage-sensitive-dyes-for-studying-spatiotemporal-dynamics-in-the-brain-visualizing-cortical-waves
#10
Xinling Geng, Jian-Young Wu
Among many distinct contributions made by Amiram Grinvald's group, the "Blue dyes" is a special gift for visualizing cortical population neuronal activity. The excitation wavelength of blue dyes has minimal overlap with the absorption of hemoglobin, and hence has minimal pulsation artifacts. This advantage leads to high signal-to-noise ratio optical recordings of cortical activity, with sensitivity as good as that of local field potential recordings. High sensitivity imaging allows for recording of spontaneous and evoked activity in single trials without spatial or temporal averaging, and has benefitted many scientists in their research projects...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28284078/a-highly-sensitive-electrochemical-immunosensor-for-hepatitis-b-virus-surface-antigen-detection-based-on-hemin-g-quadruplex-horseradish-peroxidase-mimicking-dnazyme-signal-amplification
#11
Negar Alizadeh, Rahman Hallaj, Abdollah Salimi
Here we prepared an electrochemical immunosensor employing Au sheet as working electrode, Fe3O4 magnetic nanoparticles (MNPs) as supporting matrix and hemin/G-quadruplex DNAzyme as signal amplifier for determination of hepatitis B virus surface antigen (HBsAg). First, the primary antibody of HBs (Ab1) was immobilized on the surface of the carboxyl-modified MNPs. Then, the assembly of antibody and alkylthiol/G-quadruplex DNA/hemin on gold nanoparticles was used as bio-bar-coded nanoparticle probe. Protein target was sandwiched between the primary antibody of HBs (Ab1) immobilized on the MNPs and hemin bio-bar-coded AuNPs probe labeled antibody (Ab2)...
February 24, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28283016/metafounders-are-related-to-f-st-fixation-indices-and-reduce-bias-in-single-step-genomic-evaluations
#12
Carolina A Garcia-Baccino, Andres Legarra, Ole F Christensen, Ignacy Misztal, Ivan Pocrnic, Zulma G Vitezica, Rodolfo J C Cantet
BACKGROUND: Metafounders are pseudo-individuals that encapsulate genetic heterozygosity and relationships within and across base pedigree populations, i.e. ancestral populations. This work addresses the estimation and usefulness of metafounder relationships in single-step genomic best linear unbiased prediction (ssGBLUP). RESULTS: We show that ancestral relationship parameters are proportional to standardized covariances of base allelic frequencies across populations, such as [Formula: see text] fixation indexes...
March 10, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28238259/versatile-spectral-and-lifetime-multiplexing-nanoplatform-with-excitation-orthogonalized-upconversion-luminescence
#13
Hao Dong, Ling-Dong Sun, Wei Feng, Yuyang Gu, Fuyou Li, Chun-Hua Yan
Optical encoding together with color multiplexing benefits on-site detection, and enriching the components with narrow emissions from lanthanide could greatly increase the coding density. Here, we show a typical example to combine emission color and lifetime that are simultaneously integrated in a single lanthanide nanoparticle. With the multicompartment core/shell structure, the nanoparticles can activate different emitting pathways under varied excitation. This enables the nanoparticles to generate versatile excitation orthogonalized upconversion luminescence in both emission colors and lifetimes...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28224923/high-throughput-sequencing-reveals-modulation-of-micrornas-in-vigna-mungo-upon-mungbean-yellow-mosaic-india-virus-inoculation-highlighting-stress-regulation
#14
Anirban Kundu, Sujay Paul, Avishek Dey, Amita Pal
MicroRNAs (miRNAs) are 20-24 nucleotides long non-coding RNAs known to play important regulatory roles during biotic and abiotic stresses by controlling gene expression. Blackgram (Vigna mungo), an economically important grain legume is highly susceptible to pathogenic begomovirus Mungbean Yellow Mosaic India Virus (MYMIV) and resulting in high yield loss. In this study two different leaf-small-RNA libraries were prepared from the pooled RNA at three different time points of resistant V. mungo inbred line VM84 inoculated either with viruliferous or non-viruliferous whiteflies carrying MYMIV and performed high-throughput Illumina sequencing...
April 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28197558/chemical-memory-with-states-coded-in-light-controlled-oscillations-of-interacting-belousov-zhabotinsky-droplets
#15
Konrad Gizynski, Jerzy Gorecki
The information storing potential of droplets, in which an oscillatory, photosensitive Belousov-Zhabotinsky (BZ) reaction proceeds, is investigated experimentally. We consider coupled oscillations in pairs and triplets of droplets. Droplets are surrounded by a solution of lipids in decane. Oscillations synchronize via diffusion of an activator through a lipid bilayer. The reaction in each droplet can be individually controlled by illumination with blue light through an optical fiber. We found that in pairs of BZ droplets, only the in-phase and the forcing oscillation modes are stable, however switching between these modes is not reliable...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28181801/optokinetically-encoded-nanoprobe-based-multiplexing-strategy-for-microrna-profiling
#16
Sungi Kim, Jeong-Eun Park, Woosung Hwang, Jinyoung Seo, Young-Kwang Lee, Jae-Ho Hwang, Jwa-Min Nam
Multiplexed real-time analysis on multiple interacting molecules and particles is needed to obtain information on binding patterns between multiple ligands and receptors, specificity of bond formations, and interacting pairs in a complex medium, often found in chemical and biological systems, and difference in binding affinity and kinetics for different binding pairs in one solution. In particular, multiplexed profiling of microRNA (miRNA) in a reliable, quantitative manner is of great demand for the use of miRNA in cell biology, biosensing, and clinical diagnostic applications, and accurate diagnosis of cancers with miRNA is not possible without detecting multiple miRNA sequences in a highly specific manner...
February 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28179193/light-curing-procedures-performance-knowledge-level-and-safety-awareness-among-dentists
#17
S E Kopperud, H V Rukke, H M Kopperud, E M Bruzell
OBJECTIVES: This study aimed to investigate dentists' exposure to curing light and to obtain information about the dentists' knowledge on practical use and technical features of their curing lights as well as their safety awareness. METHODS: A pre-coded questionnaire was sent electronically to all dentists (n=1313) in the Public Dental Service (PDS) in Norway in 2015. RESULTS: The Response rate was 55.8%. The dentists spent on average 57.5% of their working days placing restorations, ranging from 1 to 30 (mean 7...
February 6, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28156462/patterns-of-palliative-care-utilization-and-end-of-life-care-in-adult-patients-with-cancer-who-died-as-inpatients-at-mayo-clinic
#18
Shivani S Shinde, Pashtoon Murtaza Kasi, Mark Robert Litzow, Jeanne M Huddleston
60 Background: A significant number of patients with advanced cancer die in the hospital. Examination of patterns of care and palliative care (PC) involvement may identify opportunities for process of care improvements for this vulnerable population. METHODS: Patients were identified using the institutional mortality review system registry (Mayo Clinic hospitals from July, 2013-June, 2014). Within this group, patients with a diagnosis of terminal malignancy were identified by chart review and ICD-9 codes...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28141678/frequency-of-severe-infusion-reactions-associated-with-outpatient-infusion-of-infliximab-without-pre-medications
#19
Stephanie Q Hutsell, May Wu, K T Park
In this report, we describe incremental changes, over a two year period at a single center with the administration of maintenance infliximab infusions. Given practice-driven changes consisting of one-hour infusions and omission of pre-medications, we aimed to investigate if these changes contributed to severe infusion reactions. We reviewed approximately 900 infliximab infusions in a pediatric ambulatory infusion center from January 1, 2014-December 31, 2015 for severe adverse reactions requiring either rescue epinephrine or a code blue or 'rapid response' activation...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28129413/do-twins-share-the-same-dress-code-quantifying-relative-genetic-and-environmental-contributions-to-subjective-perceptions-of-the-dress-in-a-classical-twin-study
#20
Omar A Mahroo, Katie M Williams, Ibtesham T Hossain, Ekaterina Yonova-Doing, Diana Kozareva, Ammar Yusuf, Ibrahim Sheriff, Mohamed Oomerjee, Talha Soorma, Christopher J Hammond
The phenomenon of contrasting color perceptions of "the dress" photograph has gained scientific interest. The mechanism underlying why individuals differ is yet to be fully explained. We use the powerful twin model design to ascertain the relative contribution of genetic and environmental factors on perception variation. A sample of 466 twins from the British TwinsUK registry were invited to report what color they saw in a standard image of the dress in standard illumination. The mean age of the participants was 49...
January 1, 2017: Journal of Vision
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