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https://www.readbyqxmd.com/read/29650329/perceptions-of-hospital-emergency-color-codes-among-hospital-employees-in-korea
#1
Hyo-Jin Lee, Ogcheol Lee
INTRODUCTION: Hospital emergency codes frequently comprise of colors to prevent confusion and enhance prompt response to emergency situations. The purpose of this study was to identify perceptions of emergency color codes among hospital employees in Korea. METHODS: A 12-color spectrum and emergency situations were selected from the standardized emergency color codes used in the US and Canada. Participants were selected via convenience sampling from four general hospitals in Seoul and Gyeonggi-Do...
April 9, 2018: International Emergency Nursing
https://www.readbyqxmd.com/read/29628835/analysis-of-functioning-and-efficiency-of-a-code-blue-system-in-a-tertiary-care-hospital
#2
Srinivas Monangi, Rangraj Setlur, Ramprasad Ramanathan, Sidharth Bhasin, Mridul Dhar
Background: "Code blue" (CB) is a popular hospital emergency code, which is used by hospitals to alert their emergency response team of any cardiorespiratory arrest. The factors affecting the outcomes of emergencies are related to both the patient and the nature of the event. The primary objective was to analyze the survival rate and factors associated with survival and also practical problems related to functioning of a CB system (CBS). Materials and Methods: After the approval of hospital ethics committee, an analysis and audit was conducted of all patients on whom a CB had been called in our tertiary care hospital over 24 months...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29620229/mir%C3%A2-22%C3%A2-3p-enhances-multi%C3%A2-chemoresistance-by-targeting-net1-in-bladder-cancer-cells
#3
Jun Xiao, Sanqiang Niu, Jiahong Zhu, Lei Lv, Hui Deng, Daqing Pan, Deyun Shen, Congyun Xu, Zhou Shen, Tao Tao
With the discovery of new chemotherapeutic drugs, chemotherapy becomes increasingly valuable. However, the resistance of tumor cells to chemotherapeutic agents significantly limits the effectiveness and causes chemotherapy failure. MicroRNAs have been shown to regulate drug resistance in many types of cancer. In the present study, we measured the chemosensitivity of five bladder cancer (BCa) cell lines to seven commonly used chemotherapeutic drugs by Vita‑Blue assay. We then identified the most sensitive (5637) and most tolerant cell lines (H‑bc) and conducted a multi‑group test...
April 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29603986/averaging-colors-of-multicolor-mosaics
#4
Eiji Kimura
The present study investigated how color information was summarized in multicolor mosaics. The mosaics were composed of small elements of 17 colors that roughly belonged to a single color category. We manipulated the degree of color variation around the mean by varying the proportion of different color elements. Observers matched the mean color of the multicolor mosaic by adjusting the color of a spatially uniform matching stimulus. Results showed that when the color variation was large, the matched color deviated from the colorimetric mean toward the most-saturated color, although the hue of the matched color was almost the same as that of the colorimetric mean...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29593244/author-correction-intergenerational-equity-can-help-to-prevent-climate-change-and-extinction
#5
Adrian Treves, Kyle A Artelle, Chris T Darimont, William S Lynn, Paul Paquet, Francisco J Santiago-Ávila, Rance Shaw, Mary C Wood
The original Article mistakenly coded the constitutional rights of Australia as containing a governmental duty to protect the environment (blue in the figures); this has been corrected to containing no explicit mention of environmental protection (orange in the figures). The original Article also neglected to code the constitutional rights of the Cayman Islands (no data; yellow in the figures); this has been corrected to containing a governmental duty to protect the environment (blue in the figures).Although no inferences changed as a result of these errors, many values changed slightly and have been corrected...
March 28, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29581742/methylene-blue-relieves-the-development-of-osteoarthritis-by-upregulating-lncrna-meg3
#6
Xinyi Li, Chaoliang Tang, Jin Wang, Peipei Guo, Chengyao Wang, Yanlin Wang, Zongze Zhang, Huisheng Wu
Methylene blue (MB) is a long-term inhibitor of peripheral nerve axons, thereby alleviating or permanently eliminating pain. However, it remains unknown whether MB is safe and effective method of treating osteoarthritis (OA). MB was injected into the knee joints of rabbits and they were monitored for any histological structural changes. The results revealed no evident changes in the histological structure of the normal knee joint following injection of 1 mg/kg MB at 1, 4, 8 and 24 weeks post-injection. Compared with the vehicle control, MB treatment significantly enhanced the weight distribution and significantly decreased the swelling ratio of the rabbits...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29577877/monomorphic-pathogens-the-case-of-candidatus-xenohaliotis-californiensis-from-abalone-in-california-usa-and-baja-california-mexico
#7
Francesco Cicala, James D Moore, Jorge Cáceres-Martínez, Miguel A Del Río-Portilla, Mónica Hernández-Rodríguez, Rebeca Vásquez-Yeomans, Axayácatl Rocha-Olivares
Withering syndrome (WS) is a chronic wasting disease affecting abalone species attributed to the pathogen Candidatus Xenohaliotis californiensis (CXc). Wild populations of blue (Haliotis fulgens) and yellow (H. corrugata) abalone have experienced unusual mortality rates since 2009 off the peninsula of Baja California and WS has been hypothesized as a possible cause. Currently, little information is available about the genetic diversity of CXc and particularly the possible existence of strains differing in pathogenicity...
March 22, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29569687/mortality-in-code-blue-can-apache-ii-and-prism-scores-be-used-as-markers-for-prognostication
#8
Nurten Bakan, Gülşah Karaören, Şenay Göksu Tomruk, Sinem Keskin Kayalar
BACKGROUND: Code blue (CB) is an emergency call system developed to respond to cardiac and respiratory arrest in hospitals. However, in literature, no scoring system has been reported that can predict mortality in CB procedures. In this study, we aimed to investigate the effectiveness of estimated APACHE II and PRISM scores in the prediction of mortality in patients assessed using CB to retrospectively analyze CB calls. METHODS: We retrospectively examined 1195 patients who were evaluated by the CB team at our hospital between 2009 and 2013...
March 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29543304/communicating-resuscitation-the-importance-of-documentation-in-cardiac-arrest
#9
Amal A Bakhsh, Abdulrahman R Bakhsh, Zainab A Karamelahi, Abdullah A Bakhsh, Abeer M Alzahrani, Lojain M Alsharif, Yasmin M Sharton, Afnan K Alotaibi, Khadeja O Basharahil
OBJECTIVES: To primarily assess documentation during in-hospital cardiopulmonary arrest resuscitation and to secondarily observe cardiopulmonary resuscitation event and outcome variables. METHODS: A retrospective review of 360 code blue forms and medical records at King Fahad General Hospital, King Abdulaziz General Hospital (Almahjar), and Althghar Hospital in Jeddah was performed between 2015 to 2016. RESULTS: Survival to discharge rates and neurological outcomes were not documented at all...
March 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29541564/comparison-of-hospital-wide-code-rates-and-mortality-before-and-after-the-implementation-of-a-rapid-response-team
#10
Muhammad Yousaf, Sheher Bano, Muhammad Attaur-Rehman, Chaudhary Muhammad Junaid Nazar, Aayesha Qadeer, Salma Khudaidad, Syed Waqar Hussain
Objective To compare hospital-wide code rates and mortality before and after the implementation of a rapid response team (RRT). Study design A prospective cohort design with historical controls. Place of study This study was conducted at Shifa International Hospital, Islamabad, from January 21, 2016, to January 20, 2017. Materials and methods The triggers for the rapid response team (RRT) were displayed on each floor. The in-house staff was trained on when and how to activate the rapid response team (RRT). Data were collected on a specified data collection form...
January 9, 2018: Curēus
https://www.readbyqxmd.com/read/29532313/the-phylogenetic-position-of-choerodonicola-cribb-2005-digenea-opecoelidae-with-a-partial-life-cycle-for-a-new-species-from-the-blue-barred-parrotfish-scarus-ghobban-forssk%C3%A3-l-scaridae-in-moreton-bay-australia
#11
Storm B Martin, Thomas H Cribb, Scott C Cutmore, Daniel C Huston
Choerodonicola Cribb, 2005 is a minor genus of opecoelid trematodes defined for species with exceptionally small eggs but otherwise generalised morphology. Four species are currently recognised, all from fishes collected in Japanese waters but each from different perciform families: a labrid, a scarid, a sparid and pinguipeds. We report on a new species, Choerodonicola arothokoros n. sp., from the blue-barred parrotfish Scarus ghobban Forsskål (Scaridae) collected in subtropical waters of Moreton Bay, south-east Queensland, Australia...
March 12, 2018: Systematic Parasitology
https://www.readbyqxmd.com/read/29486463/genetic-variation-in-genes-underlying-diverse-dementias-may-explain-a-small-proportion-of-cases-in-the-alzheimer-s-disease-sequencing-project
#12
Elizabeth E Blue, Joshua C Bis, Michael O Dorschner, Debby W Tsuang, Sandra M Barral, Gary Beecham, Jennifer E Below, William S Bush, Mariusz Butkiewicz, Carlos Cruchaga, Anita DeStefano, Lindsay A Farrer, Alison Goate, Jonathan Haines, Jim Jaworski, Gyungah Jun, Brian Kunkle, Amanda Kuzma, Jenny J Lee, Kathryn L Lunetta, Yiyi Ma, Eden Martin, Adam Naj, Alejandro Q Nato, Patrick Navas, Hiep Nguyen, Christiane Reitz, Dolly Reyes, William Salerno, Gerard D Schellenberg, Sudha Seshadri, Harkirat Sohi, Timothy A Thornton, Otto Valadares, Cornelia van Duijn, Badri N Vardarajan, Li-San Wang, Eric Boerwinkle, Josée Dupuis, Margaret A Pericak-Vance, Richard Mayeux, Ellen M Wijsman
BACKGROUND/AIMS: The Alzheimer's Disease Sequencing Project (ADSP) aims to identify novel genes influencing Alzheimer's disease (AD). Variants within genes known to cause dementias other than AD have previously been associated with AD risk. We describe evidence of co-segregation and associations between variants in dementia genes and clinically diagnosed AD within the ADSP. METHODS: We summarize the properties of known pathogenic variants within dementia genes, describe the co-segregation of variants annotated as "pathogenic" in ClinVar and new candidates observed in ADSP families, and test for associations between rare variants in dementia genes in the ADSP case-control study...
February 27, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29473132/error-prone-pcr-mutagenesis-and-reverse-bacterial-two-hybrid-screening-identify-a-mutation-in-asparagine-53-of-the-staphylococcus-aureus-esat6-like-component-esxb-that-perturbs-interaction-with-esxd
#13
Amany M Ibrahim, Yasser M Ragab, Khaled A Aly, Mohamed A Ramadan
The ESAT6-like Secretion System (ESS) of the human pathogen Staphylococcus aureus secretes heterodimeric virulence effectors such as EsxB and EsxD. To gain insights into the nature of EsxB-EsxD interaction, randomly mutated esxB generated by error-prone PCR was co-transformed together with esxD as adenylate cyclase fusion constructs into cyclase-deficient Escherichia coli, followed by reverse bacterial two-hybrid screening. Three color species were observed: dark blue, light blue, and white (no EsxB-EsxD interaction)...
February 22, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/29439669/a-novel-mir-375-hoxb3-cdca3-dnmt3b-regulatory-circuitry-contributes-to-leukemogenesis-in-acute-myeloid-leukemia
#14
Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao
BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulators of gene expression in all biological processes, including leukemogenesis. Recently, miR-375 has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-leukemia activity in AML is largely unknown. METHODS: Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure the expression of miR-375 and HOXB3 in leukemic cells and normal controls...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29432996/lncrna-let-inhibits-cell-viability-migration-and-emt-while-induces-apoptosis-by-up-regulation-of-timp2-in-human-granulosa-like-tumor-cell-line-kgn
#15
Qingfang Han, Wenke Zhang, Jinlai Meng, Li Ma, Aihua Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease characterized by hyperandrogenism, irregular menses, and polycystic ovaries. Several long non-coding RNAs (lncRNAs) are aberrantly expressed in PCOS patients; however, little is known about the effects of the lncRNA-low expression in tumor (lncRNA-LET) on PCOS. We aimed to explore the effects of lncRNA-LET on human granulosa-like tumor cell line, KGN. METHODS: Expression of lncRNA-LET in normal IOSE80 cells and granulosa cells was determined by qRT-PCR...
February 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29399970/analysis-of-dicer1-in-familial-and-sporadic-cases-of-transposition-of-the-great-arteries
#16
Nelly Sabbaghian, Maria C Digilio, Gillian M Blue, Timothée Revil, David S Winlaw, William D Foulkes
OBJECTIVE: We previously identified a pathogenic germline DICER1 variant in a child with transposition of the great arteries who was a member of a family with DICER1 syndrome. In view of a report linking Dicer1 knockout in murine cardiomyocytes to cardiac outflow defects, we investigated the involvement of DICER1 in transposition of the great arteries. DESIGN: We used Fluidigm access array followed by next generation sequencing to screen for variants in the coding exons, their exon/intron boundaries and the 3' untranslated region of DICER1 in patient DNA...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29394424/implementation-of-a-new-guideline-and-educational-sessions-to-reduce-low-value-continuous-pulse-oximetry-among-hospitalized-patients
#17
Scott A Helgeson, Andree H Koop, Andrew M Harrison, Jordan C Ray, Gaja F Shaughnessy, Christopher L Brett, Lauren F Cornell, Cammi L Bowman, M Caroline Burton
OBJECTIVES: The use of continuous pulse oximetry (CPOX) is ubiquitous among hospitalized patients, despite limited evidence that it improves clinical outcomes. The objective of this study was to reduce the use of CPOX among hospitalized patients in the nonintensive care unit and nonprogressive care unit settings. METHODS: This interventional trial included the creation a new local guideline for CPOX use and subsequent staff education. CPOX use, patient acuity, hospital length of stay, and code blue events were measured before and after the intervention...
February 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29383183/multi-color-rgb-marking-enables-clonality-assessment-of-liver-tumors-in-a-murine-xenograft-model
#18
Michael Thomaschewski, Kristoffer Riecken, Ludmilla Unrau, Tassilo Volz, Kerstin Cornils, Harald Ittrich, Denise Heim, Henning Wege, Ercan Akgün, Marc Lütgehetmann, Jan Dieckhoff, Michael Köpke, Maura Dandri, Daniel Benten, Boris Fehse
We recently introduced red-green-blue (RGB) marking for clonal cell tracking based on individual color-coding. Here, we applied RGB marking to study clonal development of liver tumors. Immortalized, non-tumorigenic human fetal hepatocytes expressing the human telomerase reverse transcriptase (FH-hTERT) were RGB-marked by simultaneous transduction with lentiviral vectors encoding mCherry, Venus, and Cerulean. Multi-color fluorescence microscopy was used to analyze growth characteristics of RGB-marked FH-hTERT in vitro and in vivo after transplantation into livers of immunodeficient mice with endogenous liver damage (uPA/SCID)...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382611/novel-variant-in-sp7-osx-associated-with-recessive-osteogenesis-imperfecta-with-bone-fragility-and-hearing-impairment
#19
Melissa Fiscaletti, Andrew Biggin, Bruce Bennetts, Karen Wong, Julie Briody, Verity Pacey, Catherine Birman, Craig F Munns
Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by low bone density and recurrent fractures with a wide genotypic and phenotypic spectrum. Common features include short stature, opalescent teeth, blue sclerae and hearing impairment. The majority (>90%) of patients with OI have autosomal dominant variants in COL1A1/COL1A2, which lead to defects in type 1 collagen. More recently, numerous recessive variants involving other genes have also been identified. Sp7/Osx gene, is a protein coding gene that encodes a zinc finger transcription factor, osterix, which is a member of the Sp subfamily of sequence-specific DNA-binding proteins...
January 27, 2018: Bone
https://www.readbyqxmd.com/read/29363608/implementation-of-a-colour-coded-universal-protocol-safety-initiative-in-guatemala
#20
Brad M Taicher, Shannon Tew, Ligia Figueroa, Fausto Hernandez, Sherry S Ross, Henry E Rice
BACKGROUND: Universal protocol implementation can be challenging in low-income or middle-income countries, particularly when providers work together across language barriers. The aim of this quality improvement initiative was to test the implementation of a colour-coded universal protocol in a Guatemalan hospital staffed by US and Guatemalan providers. METHODS: From 2013 to 2016, a US and Guatemalan team implemented a universal protocol at a Guatemalan surgical centre for children undergoing general surgical or urologic procedures...
January 23, 2018: BMJ Quality & Safety
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