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https://www.readbyqxmd.com/read/29439669/a-novel-mir-375-hoxb3-cdca3-dnmt3b-regulatory-circuitry-contributes-to-leukemogenesis-in-acute-myeloid-leukemia
#1
Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao
BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulators of gene expression in all biological processes, including leukemogenesis. Recently, miR-375 has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-leukemia activity in AML is largely unknown. METHODS: Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure the expression of miR-375 and HOXB3 in leukemic cells and normal controls...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29432996/lncrna-let-inhibits-cell-viability-migration-and-emt-while-induces-apoptosis-by-up-regulation-of-timp2-in-human-granulosa-like-tumor-cell-line-kgn
#2
Qingfang Han, Wenke Zhang, Jinlai Meng, Li Ma, Aihua Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disease characterized by hyperandrogenism, irregular menses, and polycystic ovaries. Several long non-coding RNAs (lncRNAs) are aberrantly expressed in PCOS patients; however, little is known about the effects of the lncRNA-low expression in tumor (lncRNA-LET) on PCOS. We aimed to explore the effects of lncRNA-LET on human granulosa-like tumor cell line, KGN. METHODS: Expression of lncRNA-LET in normal IOSE80 cells and granulosa cells was determined by qRT-PCR...
February 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29399970/analysis-of-dicer1-in-familial-and-sporadic-cases-of-transposition-of-the-great-arteries
#3
Nelly Sabbaghian, Maria C Digilio, Gillian M Blue, Timothée Revil, David S Winlaw, William D Foulkes
OBJECTIVE: We previously identified a pathogenic germline DICER1 variant in a child with transposition of the great arteries who was a member of a family with DICER1 syndrome. In view of a report linking Dicer1 knockout in murine cardiomyocytes to cardiac outflow defects, we investigated the involvement of DICER1 in transposition of the great arteries. DESIGN: We used Fluidigm access array followed by next generation sequencing to screen for variants in the coding exons, their exon/intron boundaries and the 3' untranslated region of DICER1 in patient DNA...
February 5, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29394424/implementation-of-a-new-guideline-and-educational-sessions-to-reduce-low-value-continuous-pulse-oximetry-among-hospitalized-patients
#4
Scott A Helgeson, Andree H Koop, Andrew M Harrison, Jordan C Ray, Gaja F Shaughnessy, Christopher L Brett, Lauren F Cornell, Cammi L Bowman, M Caroline Burton
OBJECTIVES: The use of continuous pulse oximetry (CPOX) is ubiquitous among hospitalized patients, despite limited evidence that it improves clinical outcomes. The objective of this study was to reduce the use of CPOX among hospitalized patients in the nonintensive care unit and nonprogressive care unit settings. METHODS: This interventional trial included the creation a new local guideline for CPOX use and subsequent staff education. CPOX use, patient acuity, hospital length of stay, and code blue events were measured before and after the intervention...
February 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29383183/multi-color-rgb-marking-enables-clonality-assessment-of-liver-tumors-in-a-murine-xenograft-model
#5
Michael Thomaschewski, Kristoffer Riecken, Ludmilla Unrau, Tassilo Volz, Kerstin Cornils, Harald Ittrich, Denise Heim, Henning Wege, Ercan Akgün, Marc Lütgehetmann, Jan Dieckhoff, Michael Köpke, Maura Dandri, Daniel Benten, Boris Fehse
We recently introduced red-green-blue (RGB) marking for clonal cell tracking based on individual color-coding. Here, we applied RGB marking to study clonal development of liver tumors. Immortalized, non-tumorigenic human fetal hepatocytes expressing the human telomerase reverse transcriptase (FH-hTERT) were RGB-marked by simultaneous transduction with lentiviral vectors encoding mCherry, Venus, and Cerulean. Multi-color fluorescence microscopy was used to analyze growth characteristics of RGB-marked FH-hTERT in vitro and in vivo after transplantation into livers of immunodeficient mice with endogenous liver damage (uPA/SCID)...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382611/novel-variant-in-sp7-osx-associated-with-recessive-osteogenesis-imperfecta-with-bone-fragility-and-hearing-impairment
#6
Melissa Fiscaletti, Andrew Biggin, Bruce Bennetts, Karen Wong, Julie Briody, Verity Pacey, Catherine Birman, Craig F Munns
Osteogenesis imperfecta (OI) is a connective tissue disorder characterized by low bone density and recurrent fractures with a wide genotypic and phenotypic spectrum. Common features include short stature, opalescent teeth, blue sclerae and hearing impairment. The majority (>90%) of patients with OI have autosomal dominant variants in COL1A1/COL1A2, which lead to defects in type 1 collagen. More recently, numerous recessive variants involving other genes have also been identified. Sp7/Osx gene, is a protein coding gene that encodes a zinc finger transcription factor, osterix, which is a member of the Sp subfamily of sequence-specific DNA-binding proteins...
January 27, 2018: Bone
https://www.readbyqxmd.com/read/29363608/implementation-of-a-colour-coded-universal-protocol-safety-initiative-in-guatemala
#7
Brad M Taicher, Shannon Tew, Ligia Figueroa, Fausto Hernandez, Sherry S Ross, Henry E Rice
BACKGROUND: Universal protocol implementation can be challenging in low-income or middle-income countries, particularly when providers work together across language barriers. The aim of this quality improvement initiative was to test the implementation of a colour-coded universal protocol in a Guatemalan hospital staffed by US and Guatemalan providers. METHODS: From 2013 to 2016, a US and Guatemalan team implemented a universal protocol at a Guatemalan surgical centre for children undergoing general surgical or urologic procedures...
January 23, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29356154/encoding-reading-and-transforming-information-using-multifluorescent-supramolecular-polymeric-hydrogels
#8
Xiaofan Ji, Ren-Tsung Wu, Lingliang Long, Xian-Sheng Ke, Chenxing Guo, Yoo-Jin Ghang, Vincent M Lynch, Feihe Huang, Jonathan L Sessler
Traditional (1D, 2D, and 3D) codes are widely used to provide convenient readouts of encoded information. However, manipulating and transforming the encoded information is typically difficult to achieve. Here, the preparation of three fluorescent (blue, green, and red) hydrogels containing both tetracationic receptor-anion recognition motifs and gel-specific fluorophores is reported, which may be used as building blocks to construct through physical adhesion fluorescent color 3D codes (Code A, Code B, and Code C) that may be read out by a smartphone...
January 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29354012/in-vivo-visualization-of-iron-oxide-enhancement-in-focal-pulmonary-inflammatory-lesions-using-a-three-dimensional-radial-gradient-echo-based-ultrashort-echo-time-sequence-a-preliminary-study
#9
Soon Ho Yoon, Chanhee Lee, Jinil Park, Jin Mo Goo, Jang-Yeon Park
Objective: To preliminarily evaluate technical feasibility of a dual-echo ultrashort echo time (UTE) subtraction MR imaging by using concurrent dephasing and excitation (CODE) sequence for visualization of iron-oxide enhancement in focal inflammatory pulmonary lesions. Materials and Methods: A UTE pulmonary MR imaging before and after the injection of clinically usable superparamagnetic iron-oxide nanoparticles, ferumoxytol, was conducted using CODE sequence with dual echo times of 0...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29337313/complete-genome-sequencing-of-the-luminescent-bacterium-vibrio-qinghaiensis-sp-q67-using-pacbio-technology
#10
Liang Gong, Yu Wu, Qijie Jian, Chunxiao Yin, Taotao Li, Vijai Kumar Gupta, Xuewu Duan, Yueming Jiang
Vibrio qinghaiensis sp.-Q67 (Vqin-Q67) is a freshwater luminescent bacterium that continuously emits blue-green light (485 nm). The bacterium has been widely used for detecting toxic contaminants. Here, we report the complete genome sequence of Vqin-Q67, obtained using third-generation PacBio sequencing technology. Continuous long reads were attained from three PacBio sequencing runs and reads >500 bp with a quality value of >0.75 were merged together into a single dataset. This resultant highly-contiguous de novo assembly has no genome gaps, and comprises two chromosomes with substantial genetic information, including protein-coding genes, non-coding RNA, transposon and gene islands...
January 16, 2018: Scientific Data
https://www.readbyqxmd.com/read/29324266/collision-risk-analysis-based-train-collision-early-warning-strategy
#11
Si-Hui Li, Bai-Gen Cai, Jiang Liu, Jian Wang
A Train Collision Early Warning System (TCEWS) has been developed for collision avoidance. However, there are few studies regarding how to evaluate the collision risk and provide an early warning concerning a preceding train on the railway. In this paper, we have found that the time for collision avoidance is constrained by the timing of events, such as wireless communication latency, driver reaction, safety protection distance and deceleration rate. Considering these timing components, the time to avoid a collision is calculated accurately...
January 8, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29323883/a-stable-blue-photosensitizer-for-color-palette-of-dye-sensitized-solar-cells-reaching-12-6-efficiency
#12
Yameng Ren, Danyang Sun, Yiming祎明 Cao曹, Hoi Nok Tsao, Yi Yuan, Shaik M Zakeeruddin, Peng Wang, Michael Grätzel
We report a blue donor-acceptor organic dye, coded as R6, which features a primary chromophore of a polycyclic aromatic hydrocarbon 9,19-dihydrobenzo[1',10']phenanthro[3',4':4,5]thieno[3,2-b]benzo[1,10]phenanthro[3,4-d]thiophene (BPT2) coupled with a diarylamine electron-donor and 4-(7-ethynylbenzo[c][1,2,5]thiadiazol-4-yl)benzoic acid acceptor. Dye R6 displays a brilliant sapphire color on a sensitized titania mesoporous film together with a Co(II/III)tris(bipyridyl)-based redox electrolyte. Significantly, such judiciously tailored DSCs achieve an impressive solar-to-electric power conversion efficiency (PCE) of 12...
January 11, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29323740/long-non-coding-rna-asbel-promotes-osteosarcoma-cell-proliferation-migration-and-invasion-by-regulating-microrna-21
#13
Jianhui Zhao, Zhongli Gao, Chao Zhang, Han Wu, Rui Gu, Rui Jiang
Osteosarcoma is the most common malignant bone tumor in children and adolescents with high rate of incidence, high frequency of recurrence and high degree of metastasis. This study aimed to investigate the effects of long noncoding RNA antisense ncRNA in the Abundant in neuroepithelium area (ANA)/B-cell translocation gene 3 (BTG3) locus (lncRNA ASBEL) on the pathogenesis of osteosarcoma. The expression levels of ASBEL in human osteoblast cells and human osteosarcoma cells were evaluated using qRT-PCR. Effects of ASBEL knockdown on cell viability, migration and invasion were detected using trypan blue exclusion assay, cell migration and invasion assay, respectively...
January 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29280907/a-quality-improvement-initiative-to-reduce-out-of-icu-cardiopulmonary-arrests-in-a-tertiary-care-hospital-in-india-a-2-year-learning-experience
#14
Vidya P Menon, Preetha Prasanna, Fabia Edathadathil, Sabarish Balachandran, Merlin Moni, Dipu Sathyapalan, Rajesh D Pai, Sanjeev Singh
QUALITY PROBLEM OR ISSUE: To assess impact of medical emergency team (MET) in reducing "out-of-ICU" cardiopulmonary arrests and identify barriers to its optimal utilization. INITIAL ASSESSMENT: Frequently observed critical clinical signs and laboratory values of "out-of-ICU" crashes were used to develop Amrita Early Warning Criteria. CHOICE OF SOLUTION: A physician-led MET was established to respond to code MET, activated by a primary nurse...
January 2018: Quality Management in Health Care
https://www.readbyqxmd.com/read/29258322/clinical-and-sociocultural-factors-associated-with-failure-to-escalate-care-of-deteriorating-patients
#15
Firas S Elmufdi, Susan L Burton, Nishant Sahni, Craig R Weinert
In-hospital medical emergencies occur frequently. Understanding how clinicians respond to deteriorating patients outside the intensive care unit (ICU) could improve "rescue" interventions and rapid response programs. This was a qualitative study with interviews with 40 clinicians caring for patients who had a "Code Blue" activation or an unplanned ICU admission at teaching hospitals over 7 months. Four study physicians independently analyzed interview transcripts; refined themes were linked to the transcript using text analysis software...
December 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29237067/experimental-and-monte-carlo-investigations-of-bcf-12-small%C3%A2-area-plastic-scintillation-detectors-for-neutron-pinhole-camera
#16
J Bielecki, K Drozdowicz, D Dworak, A Igielski, W Janik, A Kulinska, L Marciniak, M Scholz, M Turzanski, U Wiacek, U Woznicka, A Wójcik-Gargula
Plastic organic scintillators such as the blue-emitting BCF-12 are versatile and inexpensive tools. Recently, BCF-12 scintillators have been foreseen for investigation of the spatial distribution of neutrons emitted from dense magnetized plasma. For this purpose, small-area (5 mm × 5 mm) detectors based on BCF-12 scintillation rods and Hamamatsu photomultiplier tubes were designed and constructed at the Institute of Nuclear Physics. They will be located inside the neutron pinhole camera of the PF-24 plasma focus device...
December 11, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29223880/tomato-plants-use-non-enzymatic-antioxidant-pathways-to-cope-with-moderate-uv-a-b-irradiation-a-contribution-to-the-use-of-uv-a-b-in-horticulture
#17
N Mariz-Ponte, R J Mendes, S Sario, J M P Ferreira de Oliveira, P Melo, C Santos
Plants developed receptors for solar UV-A/B radiation, which regulate a complex network of functions through the plant's life cycle. However, greenhouse grown crops, like tomato, are exposed to strongly reduced UV radiation, contrarily to their open-field counterparts. A new paradigm of modern horticulture is to supplement adequate levels of UV to greenhouse cultures, inducing a positive mild stress necessary to stimulate oxidative stress pathways and antioxidant mechanisms. Protected cultures of Solanum (cv MicroTom) were supplemented with moderate UV-A (1h and 4h) and UV-B (1min and 5min) doses during the flowering/fruiting period...
December 6, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29219208/lncrna-h19-promotes-epithelial-mesenchymal-transition-emt-by-targeting-mir-484-in-human-lung-cancer-cells
#18
Qianqian Zhang, Xiaoliang Li, Xiao Li, Xiaosu Li, Zhuochang Chen
BACKGROUND: Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic gene in multiple cancer types. However, the molecular basis for this observation has not been characterized in lung cancer, especially during epithelial mesenchymal transition (EMT) progression. METHODS: Cell viability, migration, invasion, and apoptosis were measured using trypan blue exclusion assay, Transwell migration/invasion assay, andflow cytometry, respectively...
December 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29214167/comparison-of-us-strain-elastography-and-entero-mri-to-typify-the-mesenteric-and-bowel-wall-changes-during-crohn-s-disease-a-pilot-study
#19
Giuseppe Lo Re, Dario Picone, Federica Vernuccio, Laura Scopelliti, Ambra Di Piazza, Chiara Tudisca, Salvatore Serraino, Giambattista Privitera, Federico Midiri, Sergio Salerno, Massimo Midiri, Tommaso Vincenzo Bartolotta, Roberto Lagalla
Purpose: To evaluate and compare the mesenteric and bowel wall changes during Crohn's disease (CD) on ultrasonography (US) Strain Elastography (SE) and Enterography Magnetic Resonance Imaging (E-MRI). Methods: From July 2014 to September 2016, 35 patients with ileocolonoscopy diagnosis of CD were prospectively examined with E-MRI and in the same time with US and SE. Results: A total of 41 affected bowel segments and 35 unaffected bowel segments in 35 patients were evaluated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29204178/biological-evaluation-docking-and-molecular-dynamic-simulation-of-some-novel-diaryl-urea-derivatives-bearing-quinoxalindione-moiety
#20
Sedighe Sadeghian-Rizi, Ghadamali Ali Khodarahmi, Amirhossein Sakhteman, Ali Jahanian-Najafabadi, Mahboubeh Rostami, Mahmoud Mirzaei, Farshid Hassanzadeh
In this study a series of diarylurea derivatives containing quinoxalindione group were biologically evaluated for their cytotoxic activities using MTT assay against MCF-7 and HepG2 cell lines. Antibacterial activities of these compounds were also evaluated by Microplate Alamar Blue Assay (MABA) against three Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi), three Gram-positive (Staphylococcus aureus, Bacillus subtilis and Listeria monocitogenes) and one yeast-like fungus (Candida albicans) strain...
December 2017: Research in Pharmaceutical Sciences
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