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https://www.readbyqxmd.com/read/28224923/high-throughput-sequencing-reveals-modulation-of-micrornas-in-vigna-mungo-upon-mungbean-yellow-mosaic-india-virus-inoculation-highlighting-stress-regulation
#1
Anirban Kundu, Sujay Paul, Avishek Dey, Amita Pal
MicroRNAs (miRNAs) are 20-24 nucleotides long non-coding RNAs known to play important regulatory roles during biotic and abiotic stresses by controlling gene expression. Blackgram (Vigna mungo), an economically important grain legume is highly susceptible to pathogenic begomovirus Mungbean Yellow Mosaic India Virus (MYMIV) and resulting in high yield loss. In this study two different leaf-small-RNA libraries were prepared from the pooled RNA at three different time points of resistant V. mungo inbred line VM84 inoculated either with viruliferous or non-viruliferous whiteflies carrying MYMIV and performed high-throughput Illumina sequencing...
April 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28197558/chemical-memory-with-states-coded-in-light-controlled-oscillations-of-interacting-belousov-zhabotinsky-droplets
#2
Konrad Gizynski, Jerzy Gorecki
The information storing potential of droplets, in which an oscillatory, photosensitive Belousov-Zhabotinsky (BZ) reaction proceeds, is investigated experimentally. We consider coupled oscillations in pairs and triplets of droplets. Droplets are surrounded by a solution of lipids in decane. Oscillations synchronize via diffusion of an activator through a lipid bilayer. The reaction in each droplet can be individually controlled by illumination with blue light through an optical fiber. We found that in pairs of BZ droplets, only the in-phase and the forcing oscillation modes are stable, however switching between these modes is not reliable...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28181801/optokinetically-encoded-nanoprobe-based-multiplexing-strategy-for-microrna-profiling
#3
Sungi Kim, Jeong-Eun Park, Woosung Hwang, Jinyoung Seo, Young-Kwang Lee, Jae-Ho Hwang, Jwa-Min Nam
Multiplexed real-time analysis on multiple interacting molecules and particles is needed to obtain information on binding patterns between multiple ligands and receptors, specificity of bond formations and interacting pairs in a complex medi-um, often found in chemical and biological systems, and difference in binding affinity and kinetics for different binding pairs in one solution. In particular, multiplexed profiling of microRNA (miRNA) in a reliable, quantitative manner is of great demand for the use of miRNA in cell biology, biosensing and clinical diagnostic applications, and accurate diagnosis of cancers with miRNA is not possible without detecting multiple miRNA sequences in a highly specific manner...
February 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28179193/light-curing-procedures-performance-knowledge-level-and-safety-awareness-among-dentists
#4
S E Kopperud, H V Rukke, H M Kopperud, E M Bruzell
OBJECTIVES: This study aimed to investigate dentists' exposure to curing light and to obtain information about the dentists' knowledge on practical use and technical features of their curing lights as well as their safety awareness. METHODS: A pre-coded questionnaire was sent electronically to all dentists (n=1313) in the Public Dental Service (PDS) in Norway in 2015. RESULTS: The Response rate was 55.8%. The dentists spent on average 57.5% of their working days placing restorations, ranging from 1 to 30 (mean 7...
February 6, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28156462/patterns-of-palliative-care-utilization-and-end-of-life-care-in-adult-patients-with-cancer-who-died-as-inpatients-at-mayo-clinic
#5
Shivani S Shinde, Pashtoon Murtaza Kasi, Mark Robert Litzow, Jeanne M Huddleston
: 60 Background: A significant number of patients with advanced cancer die in the hospital. Examination of patterns of care and palliative care (PC) involvement may identify opportunities for process of care improvements for this vulnerable population. METHODS: Patients were identified using the institutional mortality review system registry (Mayo Clinic hospitals from July, 2013-June, 2014). Within this group, patients with a diagnosis of terminal malignancy were identified by chart review and ICD-9 codes...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28141678/frequency-of-severe-infusion-reactions-associated-with-outpatient-infusion-of-infliximab-without-pre-medications
#6
Stephanie Q Hutsell, May Wu, K T Park
In this report, we describe incremental changes, over a two year period at a single center with the administration of maintenance infliximab infusions. Given practice-driven changes consisting of one-hour infusions and omission of pre-medications, we aimed to investigate if these changes contributed to severe infusion reactions. We reviewed approximately 900 infliximab infusions in a pediatric ambulatory infusion center from January 1, 2014-December 31, 2015 for severe adverse reactions requiring either rescue epinephrine or a code blue or 'rapid response' activation...
January 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28129413/do-twins-share-the-same-dress-code-quantifying-relative-genetic-and-environmental-contributions-to-subjective-perceptions-of-the-dress-in-a-classical-twin-study
#7
Omar A Mahroo, Katie M Williams, Ibtesham T Hossain, Ekaterina Yonova-Doing, Diana Kozareva, Ammar Yusuf, Ibrahim Sheriff, Mohamed Oomerjee, Talha Soorma, Christopher J Hammond
The phenomenon of contrasting color perceptions of "the dress" photograph has gained scientific interest. The mechanism underlying why individuals differ is yet to be fully explained. We use the powerful twin model design to ascertain the relative contribution of genetic and environmental factors on perception variation. A sample of 466 twins from the British TwinsUK registry were invited to report what color they saw in a standard image of the dress in standard illumination. The mean age of the participants was 49...
January 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28123919/mock-code-a-code-blue-scenario-requested-by-and-developed-for-registered-nurses
#8
Kerry-Lynn Williams, Janice Rideout, Sherry Pritchett-Kelly, Melissa McDonald, Paula Mullins-Richards, Adam Dubrowski
The use of simulation in medical training is quickly becoming more common, with applications in emergency, surgical, and nursing education. Recently, registered nurses working in surgical inpatient units requested a mock code simulation to practice skills, improve knowledge, and build self-confidence in a safe and controlled environment. A simulation scenario using a high-fidelity mannequin was developed and will be discussed herein.
December 23, 2016: Curēus
https://www.readbyqxmd.com/read/28111345/transcription-activator-like-effector-mediated-regulation-of-gene-expression-based-on-the-inducible-packaging-and-delivery-via-designed-extracellular-vesicles
#9
Duško Lainšček, Tina Lebar, Roman Jerala
Transcription activator-like effector (TALE) proteins present a powerful tool for genome editing and engineering, enabling introduction of site-specific mutations, gene knockouts or regulation of the transcription levels of selected genes. TALE nucleases or TALE-based transcription regulators are introduced into mammalian cells mainly via delivery of the coding genes. Here we report an extracellular vesicle-mediated delivery of TALE transcription regulators and their ability to upregulate the reporter gene in target cells...
January 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28062690/cryptochrome-mediates-behavioral-executive-choice-in-response-to-uv-light
#10
Lisa S Baik, Keri J Fogle, Logan Roberts, Alexis M Galschiodt, Joshua A Chevez, Yocelyn Recinos, Vinh Nguy, Todd C Holmes
Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light...
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28050362/bio-medical-waste-managment-in-a-tertiary-care-hospital-an-overview
#11
Anita Pandey, Sanjiv Ahuja, Molly Madan, Ajay Kumar Asthana
INTRODUCTION: Bio-Medical Waste (BMW) management is of utmost importance as its improper management poses serious threat to health care workers, waste handlers, patients, care givers, community and finally the environment. Simultaneously, the health care providers should know the quantity of waste generated in their facility and try to reduce the waste generation in day-to-day work because lesser amount of BMW means a lesser burden on waste disposal work and cost saving. AIM: To have an overview of management of BMW in a tertiary care teaching hospital so that effective interventions and implementations can be carried out for better outcome...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048256/su-f-t-667-development-and-validation-of-dose-calculation-for-an-open-source-kv-treatment-planning-system-for-small-animal-radiotherapy
#12
S Prajapati, X Mo, B Bednarz, M Lawless, C Hammer, R Flynn, D Westerly, R Jeraj, T Mackie
PURPOSE: An open-source, convolution/superposition based kV-treatment planning system(TPS) was developed for small animal radiotherapy from previously existed in-house MV-TPS. It is flexible and applicable to both step and shoot and helical tomotherapy treatment delivery. For initial commissioning process, the dose calculation from kV-TPS was compared with measurements and Monte Carlo(MC) simulations. METHODS: High resolution, low energy kernels were simulated using EGSnrc user code EDKnrc, which was used as an input in kV-TPS together with MC-simulated x-ray beam spectrum...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025051/variations-in-normal-color-vision-vi-factors-underlying-individual-differences-in-hue-scaling-and-their-implications-for-models-of-color-appearance
#13
Kara J Emery, Vicki J Volbrecht, David H Peterzell, Michael A Webster
Observers with normal color vision vary widely in their judgments of color appearance, such as the specific spectral stimuli they perceive as pure or unique hues. We examined the basis of these individual differences by using factor analysis to examine the variations in hue-scaling functions from both new and previously published data. Observers reported the perceived proportion of red, green, blue or yellow in chromatic stimuli sampling angles at fixed intervals within the LM and S cone-opponent plane. These proportions were converted to hue angles in a perceptual-opponent space defined by red vs...
January 3, 2017: Vision Research
https://www.readbyqxmd.com/read/28024479/-construction-of-eukaryotic-expression-vector-of-sirna-specific-for-bcr-abl-fusion-gene-and-its-effects-on-k562-cells
#14
Ming Li, Bao-Lin Wang, Li-Na Wang, Ya-Ming Xi
OBJECTIVE: To construct eukaryotic expression vector of siRNA specific for BCR/ABL and to investigate the effect of recombinant plasmid on BCR/ABL and P210 protein expression in K562 cells. METHODS: siRNA(small interfering RNA)was designed according to the Tuschl's principle of Ai-based medicine, and was converted into cDNA coding expression of shRNA(small hairpin RNAs)of siRNA for BCR/ABL fusion gene. The cDNA was synthesized and inserted into plasmid pTER. The pTER117 and pTER363 of recombinant plasmid being eukaryotic expression vector was controlled by the H1 promoter of RNA polymerase III, and identified by the restriction map and the sequence analysis...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/27959574/porcine-dorsal-root-ganglia-ovarian-neurons-are-affected-by-long-lasting-testosterone-treatment
#15
B Jana, K Palus, K Meller, J Całka
We studied the effect of testosterone overdose on the number, distribution and chemical coding of ovarian neurons in the dorsal root ganglia (DRGs) in pigs. On day 3 of the estrous cycle, the ovaries of both the control and experimental gilts were injected with retrograde tracer Fast Blue. From day 4 of the estrous cycle to the expected day 20 of the second studied cycle, the experimental gilts were injected with testosterone, while the control gilts received oil. After the completion of the protocol the Th16-L5 DRGs were collected...
December 13, 2016: Physiological Research
https://www.readbyqxmd.com/read/27934878/activating-cysteinyl-leukotriene-receptor-2-cysltr2-mutations-in-blue-nevi
#16
Inga Möller, Rajmohan Murali, Hansgeorg Müller, Thomas Wiesner, Louise A Jackett, Simone L Scholz, Ioana Cosgarea, Johannes Ap van de Nes, Antje Sucker, Uwe Hillen, Bastian Schilling, Annette Paschen, Heinz Kutzner, Arno Rütten, Martin Böckers, Richard A Scolyer, Dirk Schadendorf, Klaus G Griewank
Blue nevi are common melanocytic tumors arising in the dermal layer of the skin. Similar to uveal melanomas, blue nevi frequently harbor GNAQ and GNA11 mutations. Recently, recurrent CYSLTR2 and PLCB4 mutations were identified in uveal melanomas not harboring GNAQ or GNA11 mutations. All four genes (GNAQ, GNA11, CYSLTR2, and PLCB4) code for proteins involved in the same signaling pathway, which is activated by mutations in these genes. Given the related functional consequences of these mutations and the known genetic similarities between uveal melanoma and blue nevi, we analyzed a cohort of blue nevi to investigate whether CYSLTR2 and PLCB4 mutations occur in tumors lacking GNAQ or GNA11 mutations (as in uveal melanoma)...
December 9, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27933209/prevalence-and-incidence-of-gout-in-southern-sweden-from-the-socioeconomic-perspective
#17
Meliha C Kapetanovic, Mohaned Hameed, Aleksandra Turkiewicz, Tuhina Neogi, Tore Saxne, Lennart Jacobsson, Martin Englund
OBJECTIVES: To estimate the prevalence and cumulative incidence of gout in southern Sweden with respect to socioeconomic status. METHODS: Among residents of Skåne region in the year 2013 (total population 1.3 million), adult persons (age 18 years +) who between 1998 and 2013 received a diagnosis of gout (International Classification of Disease 10th Edition (ICD-10) code M10) by any physician were identified using the Skåne Healthcare Register. We calculated the point prevalence by end of 2013 and annual cumulative incidence in 2013 standardised to the whole Skåne population according to sex, individual information on occupation (white collar/blue collar), income (low/middle/high) and level of education (primary school/high school/university)...
2016: RMD Open
https://www.readbyqxmd.com/read/27914729/operative-team-communication-during-simulated-emergencies-too-busy-to-respond
#18
W Austin Davis, Seth Jones, Adrianna M Crowell-Kuhnberg, Dara O'Keeffe, Kelly M Boyle, Suzanne B Klainer, Douglas S Smink, Steven Yule
BACKGROUND: Ineffective communication among members of a multidisciplinary team is associated with operative error and failure to rescue. We sought to measure operative team communication in a simulated emergency using an established communication framework called "closed loop communication." We hypothesized that communication directed at a specific recipient would be more likely to elicit a check back or closed loop response and that this relationship would vary with changes in patients' clinical status...
November 30, 2016: Surgery
https://www.readbyqxmd.com/read/27906259/spatiotemporal-blue-noise-coded-aperture-design-for-multi-shot-compressive-spectral-imaging
#19
Claudia V Correa, Henry Arguello, Gonzalo R Arce
Multi-shot coded aperture snapshot spectral imaging (CASSI) systems capture the spectral information of a scene using a small set of coded focal plane array (FPA) compressive measurements. Compressed sensing (CS) reconstruction algorithms are then used to reconstruct the underlying spectral 3D data cube from an underdetermined system of linear equations. Multiple snapshots result in a less ill-posed inverse problem and improved reconstructions. The only varying components in CASSI are the coded apertures, whose structure is crucial inasmuch as they determine the minimum number of FPA measurements needed for correct image reconstruction and the corresponding attainable quality...
December 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27895772/hotair-a-long-non-coding-rna-driver-of-malignancy-whose-expression-is-activated-by-foxc1-negatively-regulates-mirna-1-in-hepatocellular-carcinoma
#20
Dong-Na Su, Shi-Pin Wu, Hong-Tao Chen, Jin-Hua He
Evidence is rapidly accumulating that long non-coding RNAs (lncRNAs) are involved in human tumorigenesis and are dysregulated in multiple cancers, including hepatocellular carcinoma (HCC). lncRNAs can regulate essential pathways that contribute to tumor initiation and progression with tissue specificity, which suggests that lncRNAs may be valuable biomarkers and therapeutic targets. HOX transcript antisense intergenic RNA (HOTAIR) has previously been demonstrated to be an oncogene and a negative prognostic factor in a variety of cancers; however, the factors that contribute to the upregulation of HOTAIR and the interaction between HOTAIR and microRNAs (miRNAs or miRs) are largely unknown...
November 2016: Oncology Letters
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