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https://www.readbyqxmd.com/read/28719486/p16-expression-and-biological-behavior-of-flat-vulvar-low-grade-squamous-intraepithelial-lesions-lsil
#1
Natasha Lewis, Luis Z Blanco, Kruti P Maniar
Flat low-grade squamous intraepithelial lesion (LSIL) of the vulva [vulvar intraepithelial neoplasia (VIN) 1, flat condyloma] is an uncommon entity with poorly understood biological behavior. We aimed to determine the risk of subsequent vulvar high-grade squamous intraepithelial lesion (HSIL) or carcinoma following a diagnosis of vulvar LSIL/VIN 1, as well as the frequency and predictive value of p16 immunohistochemical expression in this setting. Of the 51 included cases, p16 positivity (diffuse block staining) was identified in 2 (4%)...
November 30, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28718952/facets-of-clinical-appearance-and-aetiology-in-an-unusual-bovine-amorphus-globosus
#2
J Weber, N Rudolph, M Freick
Amorphus globosus is a rare entity, more common in the cow but also reported in mares, buffaloes and goats. In respect of both development and clinical presentation, this abnormity can be evolved very variably. Previously, it has been discussed whether it is a form of twin pregnancy or placental teratoma. This case report deals with morphology and genetic observations in an unusual bovine amorphus globosus exhibiting a rudimentary clitoris and vulva, gut-like structures and rudimentary bones. The amorphus globosus was shown to be dizygotic to the normal male twin using the BovineSNP50 v2 BeadChip and had a genetical female sex...
July 18, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28709748/a-rare-presentation-of-primary-breast-carcinoma-in-the-vulva-a-case-report-and-literature-review
#3
Andre Lopes, Jessica St Louis, Marcelo Luiz Balancin, Angelica Nogueira-Rodrigues, Luana C F F Silva, Eduardo Paulino, Bianca Silveira Sá, Alexandra Bukowski, Edison Mantovani Barbosa, Ronaldo Lúcio Rangel Costa, Paul E Goss
No abstract text is available yet for this article.
June 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28706405/vulvar-lichen-sclerosus-et-atrophicus
#4
REVIEW
Pragya Ashok Nair
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis characterized by ivory-white plaques or patches with glistening surface commonly affecting the vulva and anus. Common symptoms are irritation, soreness, dyspareunia, dysuria, and urinary or fecal incontinence. Anogenital lichen sclerosus (LS) is characterized by porcelain-white atrophic plaques, which may become confluent extending around the vulval and perianal skin in a figure of eight configuration. Thinning and shrinkage of the genital area make coitus, urination, and defecation painful...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28700430/epidermodysplasia-verruciformis-like-hpv-infection-of-the-vulva-in-immunosuppressed-women
#5
Natkrita Pohthipornthawat, Sarah Feldman, Scott R Granter, Alvaro C Laga, Christopher P Crum, Michael Herfs
The vast majority of vulvar human papilloma virus infections are produced by α human papilloma viruses and consist of exophytic or flat warts and classic or "usual" vulvar intraepithelial neoplasia. This report details 2 examples of epidermodysplasia verruciformis-like lesions of the vulva in women who were immunosuppressed. The most consistent morphologic feature was the presence of abnormal mature keratinocytes with large pale open nuclei with small nucleoli and eosinophilic cytoplasm, situated in the upper epithelial layers...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700423/sox2-gene-amplification-and-overexpression-is-linked-to-hpv-positive-vulvar-carcinomas
#6
André Gut, Holger Moch, Matthias Choschzick
SOX2 (SRY-related HMG-box 2) belongs to the SOX gene family of high-mobility transcription factors indispensably involved in gene regulation in pluripotent stem cells and neural differentiation. SOX2 copy number increases have been frequently reported in various types of squamous cell cancer. To better understand the effect of SOX2 aberrations on vulvar cancer phenotype and patient prognosis, we analyzed SOX2 copy number changes using fluorescence in situ hybridization and SOX2 expression by immunohistochemistry in 55 squamous cell carcinomas of the vulva...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28698918/micropleura-huchzermeyeri-n-sp-camallanida-dracunculoidea-micropleuridae-from-the-nile-crocodile-crocodylus-niloticus-laurenti-reptilia-crocodylidae-in-south-africa
#7
Kerstin Junker, Yasen Mutafchiev
Micropleura huchzermeyeri n. sp. (Camallanida: Dracunculoidea: Micropleuridae) is described from the peritoneal cavity of Crocodylus niloticus Laurenti (Reptilia: Crocodylidae), based on a detailed study of its morphology using light and scanning electron microscopy. The new species is compared with its congeners, M. australiensis Moravec, Kay & Hobbs, 2004, M. vazi Travassos, 1933 and M. vivipara von Linstow, 1906 from crocodilians, and with M. indica Khera, 1951 from chelonian hosts. It can be distinguished from these by the length of its spicules, which are longer than in all described species and a combination of characters, including the presence of prominent lateral caudal papillae on the level of the cloaca in males, the presence of conspicuous phasmids on the female tail, the pre-equatorial position of the vulva and the length of the first-stage larvae...
July 11, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28697291/genitourinary-syndrome-of-menopause
#8
Elizabeth Farrell Am
BACKGROUND: Genitourinary syndrome of menopause (GSM) is the new term for vulvovaginal atrophy (VVA). Oestrogen deficiency symptoms in the genitourinary tract are bothersome in more than 50% of women, having an adverse impact on quality of life, social activity and sexual relationships. GSM is a chronic and progressive syndrome that is underdiagnosed and undertreated. OBJECTIVE: The aim of this article is to increase knowledge and understanding of GSM, improving the ability of healthcare professionals to discuss and obtain an appropriate history sensitively, and treat accordingly...
2017: Australian Family Physician
https://www.readbyqxmd.com/read/28693649/morphological-and-molecular-characterization-of-tarantobelus-arachnicida-gen-n-sp-n-nematoda-rhabditida-brevibuccidae-a-parasitic-nematode-of-tarantulas
#9
J Abolafia, R Peña-Santiago
A new genus and new species, Tarantobelus arachnicida, was found in the oral opening of tarantula spiders bred in captivity in Poland. The new species is characterized by having a small body (0.77-0.95 mm long in females and 0.66-0.84 mm in males), cuticle poorly annulated by transverse incisures, lateral field inconspicuous, lips separated with small cuticular flaps topping each lip, stoma panagrolaimoid with gymnostom well developed with robust and refringent rhabdia, pharynx panagrolaimoid with isthmus slightly longer than the basal bulb, intestine with cardiac (anterior) and rectal (posterior) areas with narrower walls...
July 11, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28686761/painful-necrotic-ulcer-on-the-vulva
#10
Eric P Sorensen, Catalina Matiz
No abstract text is available yet for this article.
June 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28662775/improved-survival-with-definitive-chemoradiation-compared-to-definitive-radiation-alone-in-squamous-cell-carcinoma-of-the-vulva-a-review-of-the-national-cancer-database
#11
Yuan James Rao, Re-I Chin, Caressa Hui, David G Mutch, Matthew A Powell, Julie K Schwarz, Perry W Grigsby, Stephanie Markovina
BACKGROUND: It is unclear whether definitive chemoradiation (CRT) results in improved overall survival compared to radiation therapy (RT) alone in patients with vulvar cancer who are not candidates for surgery. We compared these treatment strategies in the National Cancer Database (NCDB). METHODS: We identified 1352 patients with pathologically-confirmed squamous cell carcinoma of the vulva treated with definitive RT (n=353) or definitive CRT (n=999) between 2003 and 2014 in the NCDB...
June 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28657997/women-s-perception-of-their-vulvar-appearance-in-a-predominantly-low-income-minority-population
#12
Christina Truong, Stephanie Amaya, Tajnoos Yazdany
OBJECTIVES: The aim of this study was to investigate the effect of certain predictors, such as age and media exposure, on a woman's perception of her vulva anatomy. METHODS: We recruited 346 female visitors from a county teaching hospital to complete questionnaires that determine the following: demographics, satisfaction with their vulvar appearance, whether they consider their vulvar anatomy to be normal, exposure to media (namely having had Internet access or learned about genitalia from the Internet or any type of pornography), and consideration of cosmetic vulvar surgery for themselves...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28654444/lichenoid-dermatitis-of-the-vulva-diagnosis-and-differential-diagnosis-for-the-gynecologic-pathologist
#13
Marc R Lewin, Ryan W Hick, Maria A Selim
Inflammatory processes affecting the vulva may present a unique challenge due to location specific changes. Different factors are behind the intricacy in the presentation of vulvar dermatoses. First, the vulva is lined by different epithelia (hair-bearing keratinized epithelium, modified mucosa, and mucosa). Furthermore, among other factors, this organ is exposed to friction, occlusion, and trauma. Lastly, as there is a tendency to look for health care advice at an advanced stage of the disease, the lesion may be modified by secondary changes due to self-treatment...
June 26, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28640436/two-step-irradiance-schedule-versus-single-dose-cold-compress-for-pain-control-during-5-aminolevulinic-acid-based-photodynamic-therapy-of-condyloma-acuminatum
#14
Xiaonan Shao, Fang Wang, Bin Xu
OBJECTIVE: The purpose of this study was to investigate the effect of two-step irradiance schedule in relieving pain during PDT of CA. METHODS: The study was a prospective, controlled trial of 141 CA patients who were randomly divided into Group A (two-step irradiance schedule) and Group B (single-dose cold compress). The numeric rating scales (NRS) of patients' pain were recorded at 5, 10, 15, and 20 minutes during each PDT. RESULTS: The efficacy of PDT and NRS scores of patients in the two groups were compared...
June 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28634755/rhabdomyosarcoma-of-the-lower-female-genital-tract-an-analysis-of-144-cases
#15
Dimitrios Nasioudis, Michail Alevizakos, Eloise Chapman-Davis, Steven S Witkin, Kevin Holcomb
PURPOSE: The aim of the present study was to elucidate the clinico-pathological characteristics of female patients with lower genital tract rhabdomyosarcoma (RMS) stratified by age group and investigate their prognosis, using a multi-institutional database. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1973-2013) and a cohort of females diagnosed with RMS of the lower genital tract (vulva, vagina, cervix) was drawn...
August 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28630114/towards-universal-forward-genetics-using-a-draft-genome-sequence-of-the-nematode-oscheius-tipulae-to-identify-mutations-affecting-vulva-development
#16
Fabrice Besnard, Georgios Koutsovoulos, Sana Dieudonné, Mark Blaxter, Marie-Anne Félix
Mapping-by-sequencing has become a standard method to map and identify phenotype-causing mutations in model species. Here, we show that a fragmented draft assembly is sufficient to perform mapping-by-sequencing in non-model species. We generated a draft assembly and annotation of the genome of the free-living nematode Oscheius tipulae, a distant relative of the model Caenorhabditis elegans We used this draft to identify the likely causative mutations at the O. tipulae cov-3 locus, which affect vulval development...
June 19, 2017: Genetics
https://www.readbyqxmd.com/read/28624874/reliable-molecular-differentiation-of-trichuris-ovis-and-trichuris-discolor-from-sheep-ovis-orientalis-aries-and-roe-deer-capreolus-capreolus-and-morphological-characterisation-of-their-females-morphology-does-not-work-sufficiently
#17
Pavel Vejl, Stanislava Nechybová, Pavla Peřinková, Martina Melounová, Vladimíra Sedláková, Jakub Vašek, Daniela Čílová, Kateřina Rylková, Ivana Jankovská, Jaroslav Vadlejch, Iva Langrová
The main aim of the study was to evaluate associations between morphological variability of Trichuris females from sheep and roe deer and their rDNA polymorphism in whipworm populations from the Czech Republic. The results introduced the use of new molecular markers based on the internal transcribed spacer (ITS)1-5.8S RNA-ITS2 region polymorphisms, as useful tools for the unambiguous differentiation of congeners Trichuris ovis and Trichuris discolor. These markers revealed both parasites in roe deer and in sheep; however, T...
June 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28614205/spectrum-of-changes-in-anogenital-mammary-like-glands-in-primary-extramammary-anogenital-paget-disease-and-their-possible-role-in-the-pathogenesis-of-the-disease
#18
Anastasia M Konstantinova, Dominic V Spagnolo, Colin J R Stewart, Denisa Kacerovska, Ksenya V Shelekhova, Jose A Plaza, Saul Suster, Jiri Bouda, Liubov Kyrpychova, Michal Michal, Irena E Belousova, Katrin Kerl, Dmitry V Kazakov
To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). In all cases, lesions involved the vulva and in 1 patient the perianal skin was affected. Histopathologically, AGMLG manifested changes identical to columnar cell change (CCC) (87...
August 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28607383/isolation-detection-and-quantification-of-cancer-biomarkers-in-hpv-associated-malignancies
#19
Hakan Inan, Shuqi Wang, Fatih Inci, Murat Baday, Richard Zangar, Sailaja Kesiraju, Karen S Anderson, Brian T Cunningham, Utkan Demirci
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in the development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In the development of cancer, persistent HPV infections induce E6 and E7 oncoproteins, which promote cell proliferation and carcinogenesis resulting elevated levels of host antibodies (e.g., anti-HPV16 E7 antibody). Currently, these cancers are clinically diagnosed using invasive biopsy-based tests, which are performed only in centralized labs by experienced clinical staff using time-consuming and expensive tools and technologies...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28593777/-aggressive-angiomyxoma-case-report
#20
K Nováková, P Vážan
OBJECTIVE: We present a case report of 47-years old woman with a rare mesenchymal tumor misdiagnosed as a cyst Bartholins gland. DESIGN: Case report. SETTING: Department of Gynecology, Hospital Atlas, EUC, in ZlínConclusion: Aggressive angiomyxoma is a rare mesenchymal tumor, which is occuring more in women, affects the vulva, perineum and pelvis. Typical is slowly and infiltrative growth with high-risk of local recurence.
2017: Ceská Gynekologie
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