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Diabetes and pregnancy

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https://www.readbyqxmd.com/read/29667703/diagnosis-and-management-practices-for-gestational-diabetes-mellitus-in-australia-cross-sectional-survey-of-the-multidisciplinary-team
#1
Nina Meloncelli, Adrian Barnett, Fiona Pelly, Susan de Jersey
BACKGROUND: Gestational diabetes mellitus (GDM) is one of the most common pregnancy disorders; however, if well managed, women with GDM experience similar pregnancy outcomes to those without. Currently, there is limited evidence on actual management practices across Australia or how multidisciplinary teams interact to optimise care. AIMS: To examine the current screening, diagnostic, task and role perceptions and management practices, as reported by members of the GDM multidisciplinary team...
April 18, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29666681/implications-of-early-pregnancy-obesity-on-maternal-fetal-and-neonatal-health-retrospective-cohort-study-from-oman
#2
Anita Zutshi, Jayasree Santhosh, Julie Sheikh, Fareeha Naeem, Ahmed Al-Hamedi, Shahla Khan, Eishthiag Al-Said
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29663517/continuous-glucose-monitoring-results-in-lower-hba-1c-in-malaysian-women-with-insulin-treated-gestational-diabetes-a-randomized-controlled-trial
#3
S S Paramasivam, K Chinna, A K K Singh, J Ratnasingam, L Ibrahim, L L Lim, A T B Tan, S P Chan, P C Tan, S Z Omar, R W Bilous, S R Vethakkan
AIMS: To determine if therapeutic, retrospective continuous glucose monitoring (CGM) improves HbA1c with less hypoglycaemia in women with insulin-treated gestational diabetes mellitus (GDM). METHODS: This prospective, randomized controlled, open-label trial evaluated 50 women with insulin-treated GDM randomized to either retrospective CGM (6-day sensor) at 28, 32 and 36 weeks' gestation (Group 1, CGM, n = 25) or usual antenatal care without CGM (Group 2, control, n = 25)...
April 16, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29660612/perfluoroalkyl-substances-and-glycemic-status-in-pregnant-danish-women-the-odense-child-cohort
#4
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Helle Raun Andersen, Philippe Grandjean, Tina Kold Jensen, Marianne Andersen
BACKGROUND: Perfluoroalkyl substances (PFASs) are persistent chemicals with suspected endocrine disrupting abilities applied in consumer products. PFASs have potentially modulating effects on glucose homeostasis. Insulin resistance prevails during third trimester of pregnancy, and this challenge of glucose homeostasis may reveal putative effects of PFAS concentrations on glycemic status. OBJECTIVE: To investigate associations between five serum PFASs and glucose-related outcomes in pregnant Danish women based on their risk of gestational diabetes mellitus (GDM)...
April 13, 2018: Environment International
https://www.readbyqxmd.com/read/29651319/effects-of-perinatal-factors-on-body-mass-index-and-physical-fitness-of-school-age-children
#5
Miha Lucovnik, Gregor Starc, Petra Golja, Ivan Verdenik, Irena Stucin Gantar
Objective: To examine the effects of various maternal and neonatal perinatal factors on the child's body mass index (BMI) and physical fitness at school-age. Methods: Data from two registries, the SLOfit database (a national surveillance system of children's motor and physical development) and Slovenian National Perinatal Information System (NPIS) were analysed. Perinatal data for 2,929 children born in 2008 were linked to results of SLOfit testing of these children in 2016...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29650351/overexpression-of-st5-an-activator-of-ras-has-no-effect-on-%C3%AE-cell-proliferation-in-adult-mice
#6
Kristy Ou, Jia Zhang, Yang Jiao, Zhao V Wang, Phillipp Scherer, Klaus H Kaestner
OBJECTIVE: Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore β-cell mass have been met with limited success. Suppression of Tumorigenicity 5 (ST5) activates Ras/Erk signaling in the presence of Epidermal Growth Factor (EGF). In the pancreatic islet, Ras/Erk signaling is required for augmented β-cell proliferation during pregnancy, suggesting that ST5 is an appealing candidate to enhance adult β-cell proliferation...
March 23, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29650105/diabetes-and-pregnancy
#7
Denice S Feig, Howard Berger, Lois Donovan, Ariane Godbout, Tina Kader, Erin Keely, Rema Sanghera
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29649540/incidence-risk-factors-and-pregnancy-outcomes-of-gestational-diabetes-mellitus-using-one-step-versus-two-step-diagnostic-approaches-a-population-based-cohort-study-in-isfahan-iran
#8
Elham Hosseini, Mohsen Janghorbani, Ashraf Aminorroaya
AIMS: To study the incidence, risk factors, and pregnancy outcomes associated with gestational diabetes mellitus (GDM) diagnosed with one-step and two-step screening approaches. METHODS: 1000 pregnant women who were eligible and consented to participate underwent fasting plasma glucose testing at the first prenatal visit (6-14 weeks). The women free from GDM or overt diabetes were screened at 24-28 weeks using the 50-g glucose challenge test (GCT) followed by 100-g, 3-h oral glucose tolerance test (OGTT) (two-step method)...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29644330/pregnancy-complications-in-infertile-patients-with-polycystic-ovary-syndrome-updated-evidences
#9
Stefano Palomba, Angela Falbo, Jessica Daolio, Francesco A Battaglia, Giovanni B LA Sala
Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642923/association-of-maternal-serum-lipids-at-late-gestation-with-the-risk-of-neonatal-macrosomia-in-women-without-diabetes-mellitus
#10
Xiangxiang Wang, Qingbo Guan, Jiajun Zhao, Feifei Yang, Zhongshang Yuan, Yongchao Yin, Rui Fang, Lingwei Liu, Changting Zuo, Ling Gao
BACKGROUND: Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM)...
April 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29642898/enablers-and-barriers-for-women-with-gestational-diabetes-mellitus-to-achieve-optimal-glycaemic-control-a-qualitative-study-using-the-theoretical-domains-framework
#11
Ruth Martis, Julie Brown, Judith McAra-Couper, Caroline A Crowther
BACKGROUND: Glycaemic target recommendations vary widely between international professional organisations for women with gestational diabetes mellitus (GDM). Some studies have reported women's experiences of having GDM, but little is known how this relates to their glycaemic targets. The aim of this study was to identify enablers and barriers for women with GDM to achieve optimal glycaemic control. METHODS: Women with GDM were recruited from two large, geographically different, hospitals in New Zealand to participate in a semi-structured interview to explore their views and experiences focusing on enablers and barriers to achieving optimal glycaemic control...
April 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29642754/daily-gentamicin-using-ideal-body-weight-demonstrates-lower-risk-of-postpartum-endometritis-and-increased-chance-of-successful-outcome-compared-with-traditional-8-hour-dosing-for-the-treatment-of-intrapartum-chorioamnionitis
#12
Daniel Martingano, Audrey Renson, Sharon Rogoff, Shailini Singh, Meera Kesavan Nasir, Juliette Kim, Jeanne Carey
BACKGROUND: Clinical chorioamnionitis complicates approximately 1-4% of pregnancies overall. Although universal agreement does not exist regarding the antibiotic regimen of choice, most studies have evaluated intravenous ampicillin dosed at 2 g every 6 hours plus gentamicin dosed every 8 hours. Only three studies have examined daily gentamicin for the treatment of intrapartum chorioamnionitis and thus is insufficiently investigated. OBJECTIVE: This study seeks to determine whether daily dosing of gentamicin using ideal body weight for the treatment of intrapartum chorioamnionitis is more or equivalently efficacious when compared to traditional 8-hour dosing regimens...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29630009/pregnancy-exercise-and-nutrition-with-smartphone-application-support-a-randomized-controlled-trial
#13
Maria A Kennelly, Kate Ainscough, Karen L Lindsay, Elizabeth OʼSullivan, Eileen R Gibney, Mary McCarthy, Ricardo Segurado, Giuseppe DeVito, Orla Maguire, Thomas Smith, Mensud Hatunic, Fionnuala M McAuliffe
OBJECTIVE: To evaluate the effect of a healthy lifestyle package (an antenatal behavior change intervention supported by smartphone application technology) on the incidence of gestational diabetes mellitus (GDM) in overweight and obese women. METHODS: Women with body mass indexes (BMIs) 25-39.9 were enrolled into this randomized controlled trial. The intervention consisted of specific dietary and exercise advice that addressed behavior change supported by a tailor-designed smartphone application...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29629925/reducing-maternal-mortality-and-severe-maternal-morbidity-the-role-of-critical-care
#14
Amir A Shamshirsaz, Gary A Dildy
Throughout most of the 20th century, the risk of maternal mortality in high resource countries decreased dramatically; however, this trend recently has stalled in the United States and appears to have reversed. Equally alarming is that for every reported maternal death, there are numerous severe maternal morbidities or near misses. Shifting maternal demographics (eg, obesity, advanced maternal age, multifetal pregnancies), with attendant significant medical comorbidities (eg, hypertension, diabetes, cardiac disease) and the increase in cesarean deliveries significantly contribute to increased maternal morbidity and mortality...
April 6, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29627447/gestational-diabetes-mellitus-multi-disciplinary-treatment-approaches
#15
Evangelia Kintiraki, Dimitrios G Goulis
Gestational Diabetes Mellitus (GDM) is the most common metabolic disease of pregnancy, associated with several perinatal complications. Adequate glycemic control has been proved to decrease risk of GDM-related complications. Several studies have shown the beneficial effect of exercise and medical nutrition treatment on glycemic and weight control in GDM-affected women. Moreover, pharmacological agents, such as insulin and specific oral anti-diabetic agents can be prescribed safely during pregnancy, decreasing maternal blood glucose and, thus, perinatal adverse outcomes...
April 5, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29626588/risk-of-gestational-diabetes-mellitus-in-relation-to-plasma-concentrations-of-amino-acids-and-acylcarnitines-a-nested-case-control-study
#16
Cynthia Roy, Pierre-Yves Tremblay, Elhadji Assanour-Laouan-Sidi, Michel Lucas, Jean-Claude Forest, Yves Giguère, Pierre Ayotte
AIMS: Gestational diabetes mellitus (GDM) affects between 5 to 10 % of all pregnancies in Canada and can lead to adverse health outcomes in both the mother and fetus. Amino acids (AA) and acylcarnitines (AC) have been identified as early biomarkers of type 2 diabetes but their usefulness in screening for GDM has yet to be demonstrated. METHODS: We conducted a nested case-control study involving 50 controls and 50 GDM cases diagnosed between the 24th and 28th week of gestation...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29626584/maternal-gestational-diabetes-and-long-term-respiratory-related-hospitalizations-of-the-offspring
#17
Omri Zamstein, Eyal Sheiner, Tamar Wainstock, Daniella Landau, Asnat Walfisch
AIMS: To assess the implications of gestational diabetes mellitus (GDM) on long-term respiratory related hospitalizations of the offspring. METHODS: A population-based cohort analysis including singleton pregnancies delivered between the years 1991 to 2014 in a tertiary referral hospital was conducted. Incidence of hospitalizations (up to age 18 years) due to various respiratory diseases was compared between offspring of GDM-complicated pregnancies and normoglycemic pregnancies...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29626099/incidence-risk-factors-and-clinical-characteristics-of-peripartum-cardiomyopathy-in-south-korea
#18
Sunki Lee, Geum Joon Cho, Geun U Park, Log Young Kim, Tae-Seon Lee, Do Young Kim, Suk-Won Choi, Jong-Chan Youn, Seong Woo Han, Kyu-Hyung Ryu, Jin Oh Na, Cheol Ung Choi, Hong Seog Seo, Eung Ju Kim
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a rare disorder associated with pregnancy that can lead to life-threatening conditions. The incidence and clinical characteristics of this condition remain poorly understood. METHODS AND RESULTS: We aimed to perform the first population-based study of PPCM in South Korea, using the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service. Patients who fulfilled predefined diagnostic criteria for PPCM from January 1, 2010, to December 31, 2012, were identified from International Classification of Diseases, Tenth Revision, Clinical Modification codes...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29624902/one-hour-ogtt-plasma-glucose-at-gdm-diagnosis-is-a-common-predictor-of-the-need-for-insulin-therapy-in-pregnancy-and-postpartum-impaired-glucose-tolerance
#19
Takeshi Nishikawa, Keiko Ono, Shoko Hashimoto, Hiroyuki Kinoshita, Takuro Watanabe, Hirotaka Araki, Kae Otsu, Wakana Sakamoto, Masahiro Harada, Tetsushi Toyonaga, Shoichi Kawakami, Jyunichiro Fukuda, Yoshio Haga, Daisuke Kukidome, Takeshi Takahashi, Eiich Araki
AIMS/INTRODUCTION: Because gestational diabetes mellitus (GDM) is a risk for adverse perinatal outcomes, and patients with a history of GDM have an increased risk of impaired glucose tolerance (IGT). Here, we conducted two non-interventional and retrospective studies of GDM patients in Japan. MATERIALS AND METHODS: In the first study, we enrolled 529 GDM patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum IGT...
April 6, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29623593/efficacy-and-safety-of-rapid-acting-insulin-analogs-in-special-populations-with-type-1-diabetes-or-gestational-diabetes-systematic-review-and-meta-analysis
#20
REVIEW
Kirsten Nørgaard, Nithya Sukumar, Snorri B Rafnsson, Ponnusamy Saravanan
INTRODUCTION: To assess the efficacy and safety of three available rapid-acting insulin analogs (insulins lispro, aspart and glulisine, respectively) in pregnant women, children/adolescents and people using continuous subcutaneous insulin infusion (CSII) with type 1 diabetes. METHODS: PubMed, EMBASE and Cochrane Reviews were searched electronically, and their bibliographies examined to identify suitable studies for review and inclusion in a meta-analysis. Eligible studies were randomized controlled trials that reported data on relevant clinical outcomes...
April 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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