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Diabetes and pregnancy

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https://www.readbyqxmd.com/read/29909515/influence-of-biliopancreatic-diversion-on-pregnancy-outcomes-in-comparison-to-other-bariatric-surgery-procedures
#1
S De Carolis, A Botta, Gelsomina Del Sordo, R Guerrisi, S Salvi, M P De Carolis, A Iaconelli, P Giustacchini, M Raffaelli, A Lanzone
BACKGROUND: Pregnancy after bariatric surgery (BS) has an increased risk for small-for-gestational-age infants (SGA), shorter length of gestation, and probably perinatal mortality. The aim of this study was to investigate if biliopancreatic diversion could impair pregnancy outcomes in comparison to other bariatric surgery procedures. METHODS: We conducted a cohort retrospective single-center study in 65 women before and after BS. Thirty-one pregnancies occurred before BS, while 109 after BS, amongst which n = 51 after biliopancreatic diversion (BPD) and n = 58 after non-malabsorptive procedures...
June 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29908773/maternal-diabetes-mellitus-and-timing-of-pubertal-development-in-daughters-and-sons-a-nationwide-cohort-study
#2
Lea L B Lauridsen, Linn H Arendt, Andreas Ernst, Nis Brix, Erik T Parner, Jørn Olsen, Cecilia H Ramlau-Hansen
OBJECTIVE: To study the association between maternal diabetes and timing of pubertal development in daughters and sons. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development...
June 13, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#3
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29907426/maternal-obesity-as-a-risk-factor-for-the-development-of-total-anomalous-pulmonary-venous-connection-in-their-offspring
#4
Evelyn G Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Klünder-Klünder, Begoña Segura-Stanford, Julio R Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T Granados Riverón, Leonardo J Mejía-Marín, Norma A Balderrabano-Saucedo, Alejandra Contreras-Ramos, Guadalupe Díaz-Rosas, Rocío Sánchez-Urbina
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. METHODS: 55 mother-child binomials with isolated TAPVC (group I) and 152 healthy mother-child binomials (group II) were included...
June 12, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29906708/biochemical-derangements-related-to-metabolic-syndrome-in-epileptic-patients-on-treatment-with-valproic-acid
#5
Yadav Nisha, Zachariah Bobby, Vaibhav Wadwekar
PURPOSE: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid. METHODS: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study...
June 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29903238/-effects-of-high-sucrose-high-fat-diet-feeding-time-on-establishment-of-a-mouse-model-of-gestational-diabetes-mellitus
#6
Jiacui Ren, Ye Ding, Lu Yin, Rui Qin, Yuanhong She, Jin Xu, Zhixu Wang
OBJECTIVE: The present study focuses on the effects of different highsucrose/high-fat diet feeding time on body weight, glucose and lipid metabolism parameters and pathological changes of pancreas and liver in pregnant mice. METHODS: Female C57 BL/6 J mice were divided into three groups randomly: normal control group( C) and two different high-sucrose/high-fat diet feeding time groups( H1 and H2). Body weight, food and energy intakes and blood glucose were measured at multiple time points before and during pregnancy...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903201/-risk-factors-of-gestational-diabetes-mellitus-among-the-re-birth-pregnant-women-in-xiamen-city-in-2015-2016
#7
Yanfeng Fan, Rongxian Xu, Lili Cai, Liqian Cai
OBJECTIVE: To discuss the risk factors of the gestational diabetes mellitus( GDM) among the re-birth pregnant women. METHODS: A total of 393 pregnant women with GDM were collected randomly according to the number of the antenatal care manual in the Maternal and Child Health Hospital in Xiamen City. Meanwhile, 393 pregnant women with normal glucose tolerance were chosen to be the control group matching withage of the GDM group. Their basic data would be analyzed, including the BMI before pregnancy, the degree of the education, the times of the abortion, the body weight gain during the pregnancy, their parental diabetes history, the birth weight of the last fetal, the history of GDM and so on...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902541/perspectives-on-diagnostic-strategies-for-hyperglycaemia-in-pregnancy-dealing-with-the-barriers-and-challenges-europe
#8
REVIEW
Aoife M Egan, Moshe Hod, Tahir Mahmood, Fidelma P Dunne
Diabetes in pregnancy (DIP) is associated with an increased risk of adverse pregnancy outcomes. Unfortunately guidelines and clinical practices vary significantly and a number of key issues remain under debate. These include: glucose cut-offs for diagnosis; the approaches of universal versus selective screening; appropriate timing of screening; and acceptability of various screening strategies to the population at risk. Economic considerations are also of importance, but unfortunately data outlining the best approach from this viewpoint are limited...
June 11, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#9
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29901410/continuous-glucose-monitoring-glycemic-variability-and-excessive-fetal-growth-in-pregnancies-complicated-by-type-1-diabetes
#10
Bethany M Mulla, Nudrat Noor, Tamarra James-Todd, Elvira Isganaitis, Tamara C Takoudes, Ashley Curran, Celestine E Warren, Karen E O'Brien, Florence M Brown
BACKGROUND: To examine trimester-specific associations among glycemic variability, fetal growth, and birthweight in pregnancies with type 1 diabetes mellitus (Type 1 DM). METHODS: In this retrospective cohort study of 41 pregnant women with Type 1 DM, we used continuous glucose monitoring (CGM) data to calculate glycemic variability (coefficient of variation of glucose) over a 7-day interval in each trimester. Clinical data, including fetal biometry, birthweight, and perinatal complications, were extracted from medical records...
June 14, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29900538/role-of-serum-biomarkers-to-optimise-a-validated-clinical-risk-prediction-tool-for-gestational-diabetes
#11
Sally K Abell, Soulmaz Shorakae, Jacqueline A Boyle, Barbora De Courten, Nigel K Stepto, Helena J Teede, Cheryce L Harrison
BACKGROUND: Clinical risk prediction tools for gestational diabetes (GDM) may be enhanced by measuring biomarkers in early pregnancy. AIM: To evaluate a two-step GDM risk prediction tool incorporating fasting glucose (FG) and serum biomarkers in early pregnancy. MATERIALS AND METHODS: High molecular weight (HMW) adiponectin, omentin-1 and interleukin-6 (IL-6) were measured at 12-15 weeks gestation in women with high risk of GDM from a randomised trial using a clinical risk prediction tool...
June 14, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29899542/prenatal-iron-exposure-and-childhood-type-1-diabetes
#12
Ketil Størdal, Harry J McArdle, Helen Hayes, German Tapia, Marte K Viken, Nicolai A Lund-Blix, Margaretha Haugen, Geir Joner, Torild Skrivarhaug, Karl Mårild, Pål R Njølstad, Merete Eggesbø, Siddhartha Mandal, Christian M Page, Stephanie J London, Benedicte A Lie, Lars C Stene
Iron overload due to environmental or genetic causes have been associated diabetes. We hypothesized that prenatal iron exposure is associated with higher risk of childhood type 1 diabetes. In the Norwegian Mother and Child cohort study (n = 94,209 pregnancies, n = 373 developed type 1 diabetes) the incidence of type 1 diabetes was higher in children exposed to maternal iron supplementation than unexposed (36.8/100,000/year compared to 28.6/100,000/year, adjusted hazard ratio 1.33, 95%CI: 1.06-1.67)...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898728/trimester-specific-phthalate-concentrations-and-glucose-levels-among-women-from-a-fertility-clinic
#13
Tamarra M James-Todd, Yu-Han Chiu, Carmen Messerlian, Lidia Mínguez-Alarcón, Jennifer B Ford, Myra Keller, John Petrozza, Paige L Williams, Xiaoyun Ye, Antonia M Calafat, Russ Hauser
BACKGROUND: Subfertile women are at increased risk of glucose intolerance in pregnancy. Based on epidemiologic studies, exposure to certain phthalates is associated with diabetes, elevated glucose, and increased insulin resistance. OBJECTIVES: To evaluate the association between urinary phthalate metabolites and pregnancy glucose levels in women seeking medically assisted reproduction. METHODS: We evaluated 245 women participating in a prospective cohort study based at a large fertility clinic who delivered live births and had data on pregnancy urinary phthalate metabolite concentrations and blood glucose levels...
June 14, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29898693/peripartum-fetal-distress-in-diabetic-women-a-retrospective-case-cohort-study
#14
B Castelijn, Kwp Hollander, J F Hensbergen, R G IJzerman, A W Valkenburg-van den Berg, Jwr Twisk, Cjm De Groot, Mgaj Wouters
BACKGROUND: Major concerns of pregnancies complicated by diabetes mellitus are an increased risk of adverse perinatal outcome. The objective of this study was to analyse the rate of fetal distress during labor in women with type 1, type 2 and gestational diabetes compared to control women. METHODS: A retrospective case-cohort study was conducted at the VU University Medical Center, Amsterdam; a tertiary care hospital. 117 women with type 1 diabetes, 59 women with type 2 diabetes, 303 women with gestational diabetes and 15,260 control women were included, who delivered between March 2004 and February 2014...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#15
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29897453/changes-over-time-in-hepatic-markers-predict-changes-in-insulin-sensitivity-beta-cell-function-and-glycemia
#16
Lakmini Pinnaduwage, Chang Ye, Anthony J Hanley, Philip W Connelly, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
Context: Serum concentrations of liver enzymes and the hepatokine fetuin-A have been linked to risk of type 2 diabetes, but their longitudinal impact on insulin resistance and beta-cell dysfunction is unclear. Objective: To evaluate the impact of changes over 2-years in fetuin-A and the liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) on changes in insulin sensitivity, beta-cell function and glycemia in women with varying degrees of previous gestational dysglycemia, reflecting a range of future diabetic risk...
April 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29896442/sonographic-estimated-fetal-weight-among-diabetics-at-%C3%A2-34-weeks-and-composite-neonatal-morbidity
#17
Leen Al-Hafez, Michael L Pirics, Suneet P Chauhan
Objectives  The objective was to assess the composite neonatal morbidity (CNM) among diabetic women with sonographic estimated fetal weight (SEFW) at 10 to 90th versus >90th percentile for gestational age (GA). Study Design  The inclusion criteria for this retrospective study were singleton pregnancies at 34 to 41 weeks, complicated by diabetes, and that had SEFW within 4 weeks of delivery. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated. Results  Among the 140 cohorts that met the inclusion criteria, 72% had SEFW at 10th to 90th percentile for GA, and 28% at >90th percentile...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29896157/continuous-blood-glucose-monitoring-reveals-enormous-circadian-variations-in-pregnant-diabetic-rats
#18
Michaela Golic, Kristin Kräker, Caroline Fischer, Natalia Alenina, Nadine Haase, Florian Herse, Till Schütte, Wolfgang Henrich, Dominik N Müller, Andreas Busjahn, Michael Bader, Ralf Dechend
Aim: Diabetes in pregnancy is a major burden with acute and long-term consequences. Its treatment requires adequate diagnosis and monitoring of therapy. Many experimental research on diabetes during pregnancy has been performed in rats. Recently, continuous blood glucose monitoring of non-pregnant diabetic rats revealed an increased circadian variability of blood glucose that made a single blood glucose measurement per day inappropriate to reflect glycemic status. Continuous blood glucose measurement has never been performed in pregnant rats...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29895203/pregnancy-after-whipple-procedure-a-new-case-and-review-of-the-literature
#19
Giulia Magoga, Laura Felder, Francesco Palazzo, Vincenzo Berghella
BACKGROUND: Whipple procedure is a complex operation usually performed to treat periampullary neoplasms. There are only four case reports of five pregnancies after Whipple procedure, with limited evidence about how to manage pregnancy after this surgery. CASE: A 28-year-old gravida 5 Para 2022 presented to our hospital at 20 weeks with worsening depression. She had a history of Whipple for a solid pseudopapillary neoplasm of the pancreas followed by two pregnancies...
June 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29894997/metabolic-syndrome-in-hyperprolactinemia
#20
Marianne Andersen, Dorte Glintborg
The metabolic syndrome (MetS) is a conglomerate of clinical findings that convey into increased morbidity and mortality from type 2 diabetes mellitus (T2D) and cardiovascular disease. Hyperprolactinemia (hyperPRL) is associated with components of MetS, especially during pregnancy. Endogenous levels of sex steroids are high during pregnancy in contrast to untreated or replaced hypogonadism in most patients with a prolactinoma and hypogonadism may confer increased risk of MetS in hyperPRL. Dopamine-D2-agonist therapy can improve MetS in patients with a prolactinoma and lower glucose levels in patients with T2D...
2018: Frontiers of Hormone Research
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