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https://www.readbyqxmd.com/read/29682916/pediatric-uveitis
#1
Nicole Shu-Wen Chan, Jessy Choi, Chui Ming Gemmy Cheung
Pediatric uveitis differs from adult-onset uveitis and is a topic of special interest because of its diagnostic and therapeutic challenges. Children with uveitis are often asymptomatic and the uveitis is often chronic, persistent, recurrent, and resistant to conventional treatment. Anterior uveitis is the most common type of uveitis in children; the prevalence of intermediate, posterior, and panuveitis varies geographically and among ethnic groups. Regarding etiology, most cases of pediatric uveitis are idiopathic but can be due to systemic inflammatory disorders, infections, or a manifestation of masquerade syndrome...
April 23, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29681844/topical-corticosteroid-resolved-rubeosis-iridis-with-neovascular-glaucoma-caused-by-noninfectious-granulomatous-uveitis
#2
Daisuke Sora, Kei Takayama, Manzo Taguchi, Tomohito Sato, Yutaka Sakurai, Takayuki Kanda, Masaru Takeuchi
Purpose: We report a case of topical corticosteroid treatment-resolved rubeosis iridis with neovascular glaucoma (NVG) caused by noninfectious granulomatous uveitis. Case Report: A 61-year-old woman with left ocular pain and blurred vision was referred to our department. Visual acuity and intraocular pressure (IOP) were 20/60 and 37 mm Hg in the left eye, respectively. Inflammatory cells, hyphema, and rubeosis iridis were observed. All laboratory tests, including multiplex polymerase chain reaction for infection using aqueous humor, were negative, and there was neither retinal occlusive vasculitis nor retinal ischemia in the fundus...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29671151/an-atypical-case-of-neurosarcoidosis-presenting-with-neovascular-glaucoma
#3
REVIEW
Melissa Vereecken, Karolien Hollanders, Deborah De Bruyn, Virginie Ninclaus, Julie De Zaeytijd, Ilse De Schryver
BACKGROUND: Sarcoidosis, a multisystem, granulomatous disorder, sometimes manifests with a neuro-ophthalmic subtype. The latter can pose a diagnostic challenge, especially when ocular symptoms appear before systemic involvement, as the clinical picture then can be non-specific and systemic laboratory and standard imaging investigations can be negative. FINDINGS: A 71-year-old woman presented with a 4-month history of sudden-onset visual loss in the left eye. Slit lamp examination revealed anterior chamber cells, iris, and angle neovascularization...
April 18, 2018: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29643784/clinical-efficacy-and-safety-of-the-ex-press-filtration-device-in-patients-with-advanced-neovascular-glaucoma-and-proliferative-diabetic-retinopathy
#4
Rana Hanna, Beatrice Tiosano, Shmuel Graffi, Dan Gaton
Background: The prognosis of conventional filtration surgery in eyes with neovascular glaucoma (NVG) is limited due to increased fibrovascular proliferation or bleeding. This study aims to evaluate the safety and efficacy of the EX-PRESS filtration device in the management of NVG associated with proliferative diabetic retinopathy (PDR). Methods: In this retrospective case series, we reviewed the medical records of patients diagnosed as having NVG associated with PDR who underwent EX-PRESS filtration surgery...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29620670/effectiveness-of-multiple-therapeutic-strategies-in-neovascular-glaucoma-patients-a-prisma-compliant-network-meta-analysis
#5
Zixian Dong, Jianyang Gong, Rongfeng Liao, Shaojun Xu
PURPOSE: Neovascular glaucoma (NVG) is a severe secondary glaucoma with uncontrolled intraocular pressure that leads to serious eye pain and vision loss. Presently, the therapeutic strategies for NVG are diverse, but the therapeutic effects are still not ideal. We performed a network analysis to assess the effect of multiple therapeutic strategies on the treatment of NVG patients. METHODS: We searched public electronic databases through April 2017 using the following keywords "neovascular glaucoma," "iris neovascularization," "hemorrhagic glaucoma," and "random" without language restrictions...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29620183/puerarin-regulates-neovascular-glaucoma-through-pigment-epithelium%C3%A2-derived-growth-factor%C3%A2-induced-nf%C3%A2-%C3%AE%C2%BAb-signaling-pathway
#6
Hui-Yu Wei, Ya-Jie Zhang, Shao-Zhen Zhao
Neovascular glaucoma is an ophthalmic disease and a potentially blinding secondary glaucoma caused by the formation of abnormal new blood vessels on the iris, which can prevent the normal drainage of water from the anterior segment of the eye. Evidence from China has suggested that puerarin benefits many diseases including myocardial infarction, stable angina, cerebral ischemia and glaucoma in a clinical setting. In the present study, the aim was to investigate the efficacies of puerarin on neovascular glaucoma in a mouse model...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29611471/peroxisome-proliferated-activated-receptors-ppars-opportunities-and-challenges-for-ocular-therapy
#7
Prachi Khatol, Shivani Saraf, Ankit Jain
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors. They exist in three isoforms (PPAR-α, PPAR-β/δ, and PPAR-Υ) in humans, but mainly PPAR-Υ, and they are expressed in retinal epithelial pigment. PPARs are involved in mediating numerous pathological implications in eye such as diabetic retinopathy (DR), choroidal neovascularization (CNV), glaucoma, diabetic macular edema, and other retinal diseases. Peroxisome proliferator-activated receptors are key players in various biological pathways like lipid degeneration, immune regulation, and reactive oxygen species regulation, regulation of vascular endothelial growth factor, matrixmetalloproteinase-9, and docosahexaenoic acid pathway...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29607552/pathophysiology-and-management-of-glaucoma-associated-with-phakomatoses
#8
REVIEW
Alisa T Thavikulwat, Deepak P Edward, Abdulrahman AlDarrab, Thasarat S Vajaranant
The phakomatoses, encephalotrigeminal angiomatosis (ETA; Sturge-Weber Syndrome), neurofibromatosis type 1 (NF1 or von Recklinghausen disease), Von Hippel-Lindau (VHL) disease, tuberous sclerosis (TSC), oculodermal melanocytosis (ODM), and phakomatosis pigmentovascularis are a group of neurocutaneous disorders that have characteristic systemic and ocular manifestations. Through many different mechanisms, they may cause glaucomatous damage of the optic nerve and subsequent vision loss varying from mild to severe...
April 1, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29578513/puncture-induced-iris-neovascularization-as-a-mouse-model-of-rubeosis-iridis
#9
Filippo Locri, Monica Aronsson, Ophélie Beaujean, Anders Kvanta, Helder André
We describe a model of puncture-induced iris neovascularization as a general model for noninvasive evaluation of angiogenesis. The model is also relevant for targeting neovascular glaucoma, a sight-threatening complication of diabetic retinopathy. This method is based on the induction of iris vascular response by a series of self-sealing uveal punctures on BALB/c mice and takes advantage of the postpartum maturation of mouse ocular vasculature. Mouse pups undergo uveal punctures from postnatal day 12.5, when the pups naturally open their eyes, until postnatal day 24...
March 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29543621/retinal-neovascularization-from-a-patient-with-cutis-marmorata-telangiectatica-congenita
#10
Thérèse M Sassalos, Taylor S Fields, Robert Levine, Hua Gao
PURPOSE: To report a rare case of peripheral retinal neovascularization in a patient diagnosed with cutis marmorata telangiectatica congenita (CMTC). METHODS: Observational case report. RESULTS: A 16-year-old girl was referred to clinic for retinal evaluation. The patient had a clinical diagnosis of CMTC later confirmed by skin biopsy. Examination revealed temporal peripheral retinal sheathing, as well as lattice degeneration in both eyes...
March 14, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29533389/rapidly-progressive-neovascular-glaucoma-from-cytomegalovirus-retinitis-in-a-non-human-immunodeficiency-virus-patient
#11
Jane Cho, Nicole Siegel, Manju L Subramanian, Howard Ying, Steven Ness
PURPOSE: To describe a case of neovascular glaucoma from cytomegalovirus (CMV) retinitis in a human immunodeficiency virus-negative patient with immunosuppression after stem-cell transplant for multiple myeloma. METHODS: Retrospective case report. RESULTS: A 71-year-old man on monthly infusion of daratumumab for multiple myeloma after stem-cell transplant presenting with a 2-week history of floaters, photophobia, and blurry vision was found to have polymerase chain reaction-confirmed CMV retinitis associated with diffuse occlusive vasculitis...
March 12, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29521039/comparison-of-polypropylene-and-silicone-ahmed%C3%A2-glaucoma-valves-in-the-treatment-of-neovascular-glaucoma-a-2-year-follow-up
#12
Wojciech Lubiński, Karol Krzystolik, Wojciech Gosławski, Leszek Kuprjanowicz, Maciej Mularczyk
BACKGROUND: Inflammation associated with biomaterials of Ahmed® glaucoma drainage devices may cause the formation of a capsule around the device and can thus have a significant influence on the level of intraocular pressure reduction. OBJECTIVES: The objective of this study was to compare the clinical outcomes after the implantation of a polypropylene or silicone Ahmed® glaucoma valve in patients with neovascular glaucoma. MATERIAL AND METHODS: In the study, 27 eyes with neovascular glaucoma (group 1) received silicon Ahmed® valves and 23 eyes (group 2) received polypropylene valves...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29503962/intraocular-and-extraocular-hemorrhage-associated-with-ligature-release-of-non-valved-glaucoma-drainage-implant
#13
Michelle Go, J Niklas Ulrich, David Fleischman
Purpose: To report a rare complication of non-valved glaucoma drainage device surgery. Observations: An 85-year-old pseudophakic white male presented with painless vision loss and bloody tears. He was 5 weeks removed from uncomplicated non-valved glaucoma drainage device (Baerveldt 101-350, [AMO, Santa Clara, CA]). There was serosanguinous discharge without apparent source and a 25% layering hyphema in the anterior chamber. The tube was unobstructed in the anterior chamber and not abutting the iris...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29487813/managing-high-risk-glaucoma-with-the-ahmed-valve-implant-20-years-of-experience
#14
Tryfon Rotsos, Anastasia Tsioga, Konstantinos Andreanos, Andreas Diagourtas, Petros Petrou, Ilias Georgalas, Dimitrios Papaconstantinou
AIM: To estimate the efficacy and safety of the Ahmed implant in patients with high risk for failure after glaucoma surgery. METHODS: In 342 eyes of 342 patients with refractory glaucoma, even with application of medical treatment, the Ahmed valve was introduced for intraocular pressure (IOP) control, in the period of the last 20y. The nature of glaucoma was neovascular in 162 eyes, pseudophakic or aphakic in 49 eyes, inflammatory in 29 eyes and non working previous antiglaucomatic surgical interventions in 102 eyes...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29485476/iris-thickness-and-severity-of-neovascular-glaucoma-determined-using-swept-source-anterior-segment-optical-coherence-tomography
#15
Shunsuke Nakakura, Yui Kobayashi, Kanae Matsuya, Etsuko Terao, Yoshiaki Kiuchi
PURPOSE: To investigate the iris thickness (IT) in neovascular glaucoma (NVG) using swept-source anterior-segment optical coherence tomography (ASOCT). PATIENTS AND METHODS: In this retrospective, clinic-based, comparative study, we enrolled 20 NVG patients (11 with 360° angle-closure [AC]-NVG and 9 with NVG without AC) and 14 healthy age-matched controls. Horizontal scanning images of swept-source ASOCT were analyzed using software calipers in temporal and nasal angle areas...
February 26, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29485475/extensive-submacular-hemorrhage-after-trabeculectomy-with-mitomycin-c
#16
Gyu-Nam Kim, Min-Ho Shin, Ja-Young Ahn, Yong-Seop Han, In-Young Chung, Seong-Wook Seo, Jong-Moon Park, Ji-Myong Yoo, Seong-Jae Kim
PURPOSE: We report the occurrence of an extensive submacular hemorrhage after trabeculectomy with mitomycin C in a patient with an occult choroidal neovascular membrane (CNVM). PATIENTS AND METHODS: The 66-year-old male patient had a 3 year history of primary open angle glaucoma in the left eye, which had been treated with topical antiglaucoma medication. The patient had age-related macular degeneration with an occult CNVM, for which he had received five intravitreal injections of ranibizumab and five intravitreal injections of bevacizumab in the left eye over a 3 year period...
February 26, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29468218/intravitreal-bevacizumab-as-therapy-for-refractory-neovascular-glaucoma-secondary-to-iris-metastasis-of-breast-carcinoma
#17
Stephanie Vale, Lorena Montalvo, Emilio Baez, Armando L Oliver
Purpose: To report a case of refractory glaucoma secondary to iris metastasis from breast cancer which was successfully treated with intravitreal bevacizumab. Observations: A 72-year-old woman presented with left ocular pain, vision loss and neovascular glaucoma secondary to iris metastasis from breast cancer. A single intravitreal injection of bevacizumab resulted in prolonged resolution of iris neovascularization, reduction of intraocular pressure and ocular pain relief...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29451146/safety-and-efficiency-of-trabectome-mediated-trabecular-meshwork-ablation-for-chinese-glaucoma-patients-a-two-year-retrospective-multicentre-study
#18
Ya-Long Dang, Yu-Jie Cen, Ying Hong, Ping Huang, Ning-Li Wang, Chao Wang, Chun Zhang
Background: The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients. Methods: This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome evaluation was a reduction in intraocular pressure (IOP), and the secondary outcomes were a reduction in glaucoma medication, the 2-year success percentages, and complications...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29450400/incidence-of-ocular-hypertension-after-intravitreal-injection-of-anti-vegf-agents-in-the-treatment-of-neovascular-amd
#19
Andreea Moraru, Gabriela Pînzaru, Anca Moţoc, Dănuţ Costin, Daniel Brănişteanu
Purpose. The assessment of the incidence of ocular hypertension over a period of 1 year in patients treated with multiple intravitreal injections of anti-VEGF agents for neovascular AMD. Methods. The study comprised 58 eyes diagnosed with neovascular age-related macular degeneration and receiving PRN intravitreal treatment with anti-VEGF agents (bevacizumab or aflibercept). The follow-up period was 1 year. Intraocular pressure was measured by using the Goldmann applanation tonometry before the intravitreal injection, at 24 hours after the administration of the anti-VEGF agent and at 1 and 4 weeks...
July 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29450382/iridex-micropulse-p3-innovative-cyclophotocoagulation
#20
M Monica Gavris, Ioana Olteanu, Erzsebet Kantor, Radu Mateescu, Roxana Belicioiu
Purpose: To present the new IRIDEX MicroPulse P3 (MP3) technology in patients with refractory glaucoma and our preliminary results at 1 week and 1 month postoperatively. Methods: IRIDEX MP3 laser cyclophotocoagulation was performed in 7 eyes of 7 patients under retrobulbar anaesthesia with lidocaine 2% in the operating room. Each eye received two treatments of 80-90s over the superior and inferior hemisphere, avoiding the temporal- and nasal-most clock hours. 810nm IRIDEX MP3 was set to 31,3% duty cycle (0,5ms treatment pulse followed by 1,1 ms of rest)...
April 2017: Romanian Journal of Ophthalmology
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