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https://www.readbyqxmd.com/read/28430329/ahmed-valves-vs-trabeculectomy-combined-with-pans-plana-vitrectomy-for-neovascular-glaucoma-with-vitreous-hemorrhage
#1
Menghua H Wang, Qiuming M Li, Hongtao T Dong, Shuqian Q Dong, Yang Li, Chunyan Y Zheng
PURPOSE: Vitreous hemorrhage is common in advanced neovascular glaucoma (NVG), which has poor visual prognosis. This study aimed to compare the efficacy of 23-G pars planar vitrectomy (PPV) combined with either Ahmed glaucoma valve (AGV) implantation or trabeculectomy after intravitreal ranibizumab (IVR) treatment for NVG with vitreous hemorrhage. METHODS: This retrospective, nonrandomized study included 33 eyes of 33 patients with NVG with vitreous hemorrhage. After IVR treatment for 3-7 days, 18 eyes underwent PPV + AGV (AGV group) and 15 underwent PPV + trabeculectomy (trabeculectomy group)...
April 14, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28427073/surgical-management-and-techniques
#2
Marco Codenotti, Lorenzo Iuliano, Gisella Maestranzi
Technical advancements have substantially extended the indications for surgery in diabetic retinopathy (DR) during the last 40 years, from the traditional indications including non-clearing vitreous hemorrhage, traction retinal detachment (RD), and traction-rhegmatogenous RD, to epiretinal membrane (ERM), vitreomacular traction, diffuse macular edema, neovascular glaucoma, and anterior hyaloid fibrovascular proliferation. The goals of vitreoretinal surgery in DR are multiple: clearing media opacities, release of traction (anteroposterior and/or tangential), segmentation and/or removal of traction bands, peeling of ERMs, hemostasis, laser photocoagulation, and tamponade of retinal breaks with gas or silicone oil...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28421723/clinical-outcomes-of-proton-beam-therapy-for-choroidal-melanoma-at-a-single-institute-in-korea
#3
Tae Wan Kim, Euncheol Choi, Jeonghoon Park, Dong-Ho Shin, Su Kyung Jung, Susie Seok, Kwan Ho Cho, Joo-Young Kim, Dae Yong Kim, Tae Hyun Kim, Yang Kwon Suh, Yeon Joo Kim, Sung Ho Moon
Purpose: This study retrospectively evaluated the clinical outcomes and complications of proton beam therapy (PBT) in a single institution in Korea and quantitatively analyzed the change in tumor volume after PBT using magnetic resonance imaging (MRI). Materials and Methods: Twenty-four treatment-naïve patients who underwent PBT for choroidal melanoma between 2009 and 2015 were reviewed. Dose fractionation was 60-70 CGE over 5 fractions. Orbital MRIs were taken at baseline and 3, 6, and 12 months after PBT and annually thereafter...
April 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28393031/efficacy-and-safety-of-intravitreal-ranibizumab-with-panretinal-photocoagulation-followed-by-trabeculectomy-compared-with-ahmed-glaucoma-valve-implantation-in-neovascular-glaucoma
#4
Jin-Tao Sun, Hai-Jing Liang, Meng An, Da-Bo Wang
AIM: To evaluate the efficacy and safety of intravitreal ranibizumab (IVR) with panretinal photocoagulation (PRP) followed by trabeculectomy compared with Ahmed glaucoma valve (AGV) implantation in neovascular glaucoma (NVG). METHODS: This was a retrospective comparative study. We reviewed the cases of a total of 45 eyes from 45 NVG patients among which 23 eyes underwent AGV implantation and the other 22 underwent trabeculectomy. The causes of neovascular glaucoma included: diabetic retinopathy (25 eyes), and retinal vein occlusion (20 eyes)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28389774/takayasu-arteritis-presenting-as-isolated-anterior-ischemic-optic-neuropathy
#5
Guohong Tian, Qian Chen, Wenji Wang
Takayasu arteritis (TA) is a systemic vasculitis of unknown etiology that affects the aorta and its primary branches or large arteries in the proximal upper or lower extremities. Ocular manifestations of TA include microaneurysm formation, small-vessel dilation, arteriovenous anastomosis, retinal ischemia, and neovascular glaucoma. We herein report a case involving a 23-year-old Asian woman who presented with isolated acute anterior ischemic optic neuropathy and was initially misdiagnosed with optic neuritis...
April 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28377036/regression-patterns-of-iris-melanoma-after-palladium-103-103-pd-plaque-brachytherapy
#6
Sonal S Chaugule, Paul T Finger
PURPOSE: To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 ((103)Pd) plaque brachytherapy. DESIGN: Retrospective, nonrandomized, interventional case series. PARTICIPANTS: Fifty patients with primary malignant melanoma of the iris. METHODS: Palladium-103 plaque brachytherapy. MAIN OUTCOME MEASURES: Changes in tumor size, pigmentation, and vascularity; incidence of iris neovascularization; and radiation-related complications...
April 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28365241/adjuvant-ab-interno-tumor-treatment-after-proton-beam-irradiation
#7
Ira Seibel, Aline I Riechardt, Jens Heufelder, Dino Cordini, Antonia M Joussen
PURPOSE: This study was performed to show long-term outcomes concerning globe preservation in uveal melanoma patients after proton beam therapy with the main focus on outcomes according to different adjuvant ab interno surgical procedures. DESIGN: Retrospective cohort study METHODS: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma between June 1998 and June 2015 were included. RESULTS: A total of 2499 patients underwent primary proton beam therapy, with local tumor control and globe preservation rates of 95...
March 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28358961/intravitreal-anti-vegf-injections-reduce-aqueous-outflow-facility-in-patients-with-neovascular-age-related-macular-degeneration
#8
Joanne C Wen, Ester Reina-Torres, Joseph M Sherwood, Pratap Challa, Katy C Liu, Guorong Li, Jason Y H Chang, Scott W Cousins, Stefanie G Schuman, Priyatham S Mettu, W Daniel Stamer, Darryl R Overby, R Rand Allingham
Purpose: We assess the effect of intravitreal anti-VEGF injections on tonographic outflow facility. Methods: Patients with age-related macular degeneration who had received unilateral intravitreal anti-VEGF injections were recruited into two groups, those with ≤10 and those with ≥20 total anti-VEGF injections. Intraocular pressure and tonographic outflow facility of injected and uninjected fellow eyes were measured and compared between groups. Risk factors for development of reduced outflow facility also were assessed...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28356708/the-efficacy-of-alahmady-ring-implantation-in-the-management-of-neovascular-glaucoma
#9
Alahmady H Alsmman, Gamal Radwan, Mohammed Elagouz, Usama Ali Mohammed
PURPOSE: To evaluate the efficacy and safety of Alahmady ring implantation in the management of neovascular glaucoma. METHODS: A total of 15 eyes of 15 patients with intractable neovascular glaucoma with intraocular pressure (IOP) ≥28 mmHg not responding to medical treatment were retrospectively analyzed. All patients had poor visual acuity and underwent Alahmady ring implantation. The ring was designed from fenestrated silicon tube used in lacrimal surgeries and was implanted subsclerally after passing it through the anterior chamber...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28327135/stratification-of-phaco-trabectome-surgery-results-using-a-glaucoma-severity-index-in-a-retrospective-analysis
#10
Pritha Roy, Ralitsa T Loewen, Yalong Dang, Hardik A Parikh, Igor I Bussel, Nils A Loewen
BACKGROUND: To stratify the outcomes of phacoemulsification combined with trabectome surgery using a new glaucoma severity index. METHODS: This is a retrospective, observational cohort study that included open angle glaucoma patients with visually significant cataract that had phacoemulsification combined with trabectome surgery. Exclusion criteria were follow-up less than 12 months, any other surgeries or diagnosis of neovascular or active uveitic glaucoma. Patients were stratified into four groups according to the Glaucoma Index (GI) that incorporated preoperative intraocular pressure (IOP), number of medications and visual field status...
March 21, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28302155/a-prospective-randomised-placebo-controlled-double-masked-three-armed-multicentre-phase-ii-iii-trial-for-the-study-of-a-topical-treatment-of-ischaemic-central-retinal-vein-occlusion-to-prevent-neovascular-glaucoma-the-strong-study-study-protocol-for-a-randomised
#11
Katrin Lorenz, Yvonne Scheller, Katharina Bell, Franz Grus, Katharina A Ponto, Felix Bock, Claus Cursiefen, Jens Flach, Marta Gehring, Tunde Peto, Rufino Silva, Yossi Tal, Norbert Pfeiffer
BACKGROUND: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most common cause of NVG is ischaemic central retinal vein occlusion (iCRVO). NVG frequently results in blindness and painful end-stage glaucomatous damage leading to the need for enucleation. Currently, there is no preventive therapy for NVG following iCRVO. Rescue treatments have severe drawbacks. Accordingly, there is a great need for preventing the often visually devastating outcomes of NVG...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28272234/neovascular-glaucoma-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#12
Jin-Woo Kwon, Donghyun Jee, Tae Yoon La
To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28226388/-can-anti-vegf-injections-cause-glaucoma-or-ocular-hypertension
#13
I Lanzl, K Kotliar
An increasing number of patients receive intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections with a high frequency for the treatment of neovascular macular disease. Since the volume of the vitreous body is temporarily increased by the injection of the substances, a short-term intraocular pressure increase after the introduction of the substance is not uncommon. However, there are more and more reports indicating that multiple injections may lead to a long-term increase in intraocular pressure...
February 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28186508/association-between-open-angle-glaucoma-and-neovascular-age-related-macular-degeneration-a-case-control-study
#14
C-C Hu, J-D Ho, H-C Lin, L-T Kao
PurposeTo investigate the relationship between previously diagnosed open-angle glaucoma (OAG) and neovascular age-related macular degeneration (AMD) using a routine insurance dataset.MethodsThis study retrieved data from the Taiwan Longitudinal Health Insurance Database 2005. We found 3282 patients with neovascular AMD as cases and 13 128 sex- and age-matched subjects without neovascular AMD as controls. Conditional logistic regressions were performed to evaluate the association of neovascular AMD with previously diagnosed OAG among the sampled patients...
February 10, 2017: Eye
https://www.readbyqxmd.com/read/28161925/the-use-of-microperimetry-to-detect-functional-progression-in-non-neovascular-age-related-macular-degeneration-a-systematic-review
#15
REVIEW
Evan N Wong, Avenell L Chew, William H Morgan, Praveen J Patel, Fred K Chen
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161916/the-pathway-from-genes-to-gene-therapy-in-glaucoma-a-review-of-possibilities-for-using-genes-as-glaucoma-drugs
#16
REVIEW
Teresa Borrás
Treatment of diseases with gene therapy is advancing rapidly. The use of gene therapy has expanded from the original concept of re-placing the mutated gene causing the disease to the use of genes to con-trol nonphysiological levels of expression or to modify pathways known to affect the disease. Genes offer numerous advantages over conventional drugs. They have longer duration of action and are more specific. Genes can be delivered to the target site by naked DNA, cells, nonviral, and viral vectors. The enormous progress of the past decade in molecular bi-ology and delivery systems has provided ways for targeting genes to the intended cell/tissue and safe, long-term vectors...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161147/factors-associated-with-worsening-proliferative-diabetic-retinopathy-in-eyes-treated-with-panretinal-photocoagulation-or-ranibizumab
#17
Susan B Bressler, Wesley T Beaulieu, Adam R Glassman, Jeffrey G Gross, Lee M Jampol, Michele Melia, Mark A Peters, Michael E Rauser
PURPOSE: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab. DESIGN: Randomized clinical trial (55 United States sites). PARTICIPANTS: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. INTERVENTION: Panretinal photocoagulation or intravitreous ranibizumab injections (0...
February 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28127658/inner-retinal-layer-change-in-glaucoma-patients-receiving-anti-vegf-for-neovascular-age-related-macular-degeneration
#18
Rafidah Saleh, Aashraya Karpe, Martin S Zinkernagel, Marion R Munk
PURPOSE: The purpose was to evaluate the effects of long-term anti-VEGF treatment on the retinal nerve fiber layer (RNFL) and retinal ganglion cell layer (RGCL) thickness for patients with neovascular AMD and glaucoma. METHODS: Medical records of respective patients who had received more than 15 anti-VEGF injections were reviewed. Initial and latest SD-OCT macular scans were segmented and changes of the RNFL and RGCL thickness at the four outer ETDRS quadrants were evaluated...
January 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28118203/evaluation-of-the-efficacy-and-safety-of-the-new-susanna-glaucoma-drainage-device-in-refractory-glaucomas-short-term-results
#19
Luis G Biteli, Tiago S Prata, Carolina P B Gracitelli, Fábio N Kanadani, Flávia Villas Boas, Marcelo Hatanaka, Augusto Paranhos Junior
PURPOSE: To assess the efficacy and safety of the new Susanna glaucoma drainage device (SGDD) in patients with neovascular and refractory glaucomas. MATERIALS AND METHODS: In this prospective study, patients with neovascular glaucoma or refractory glaucomas (defined as eyes with previous trabeculectomy failure) were enrolled. All eyes had to have intraocular pressure (IOP) above 21 mm Hg despite maximum tolerated topical medication, or recent documentation of anatomic and/or functional progression...
January 23, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28110950/vancomycin-associated-hemorrhagic-occlusive-retinal-vasculitis-clinical-characteristics-of-36-eyes
#20
Andre J Witkin, David F Chang, J Michael Jumper, Steve Charles, Dean Eliott, Richard S Hoffman, Nick Mamalis, Kevin M Miller, Charles C Wykoff
PURPOSE: To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN: Retrospective case series. PARTICIPANTS: Thirty-six eyes of 23 patients. METHODS: The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specialists (ASRS) formed a joint task force to define clinical characteristics of HORV and to study its prevalence, cause, treatment, and outcomes...
January 19, 2017: Ophthalmology
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