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Neovascular glaucoma

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https://www.readbyqxmd.com/read/28327135/stratification-of-phaco-trabectome-surgery-results-using-a-glaucoma-severity-index-in-a-retrospective-analysis
#1
Pritha Roy, Ralitsa T Loewen, Yalong Dang, Hardik A Parikh, Igor I Bussel, Nils A Loewen
BACKGROUND: To stratify the outcomes of phacoemulsification combined with trabectome surgery using a new glaucoma severity index. METHODS: This is a retrospective, observational cohort study that included open angle glaucoma patients with visually significant cataract that had phacoemulsification combined with trabectome surgery. Exclusion criteria were follow-up less than 12 months, any other surgeries or diagnosis of neovascular or active uveitic glaucoma. Patients were stratified into four groups according to the Glaucoma Index (GI) that incorporated preoperative intraocular pressure (IOP), number of medications and visual field status...
March 21, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28302155/a-prospective-randomised-placebo-controlled-double-masked-three-armed-multicentre-phase-ii-iii-trial-for-the-study-of-a-topical-treatment-of-ischaemic-central-retinal-vein-occlusion-to-prevent-neovascular-glaucoma-the-strong-study-study-protocol-for-a-randomised
#2
Katrin Lorenz, Yvonne Scheller, Katharina Bell, Franz Grus, Katharina A Ponto, Felix Bock, Claus Cursiefen, Jens Flach, Marta Gehring, Tunde Peto, Rufino Silva, Yossi Tal, Norbert Pfeiffer
BACKGROUND: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most common cause of NVG is ischaemic central retinal vein occlusion (iCRVO). NVG frequently results in blindness and painful end-stage glaucomatous damage leading to the need for enucleation. Currently, there is no preventive therapy for NVG following iCRVO. Rescue treatments have severe drawbacks. Accordingly, there is a great need for preventing the often visually devastating outcomes of NVG...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28272234/neovascular-glaucoma-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#3
Jin-Woo Kwon, Donghyun Jee, Tae Yoon La
To evaluate the prevalence and risk factors of neovascular glaucoma (NVG) after vitrectomy in patients with vitreous hemorrhage associated with proliferative diabetic retinopathy (PDR). This retrospective, noncomparative, observational study included 127 eyes of 127 patients with PDR who received vitrectomy with a follow-up period of at least 6 months. The prevalence of NVG and associated risk factors were assessed including sex, age, previous panretinal photocoagulation, baseline intraocular pressure, combined phacovitrectomy, and pretreatment with intravitreal bevacizumab (IVB) before vitrectomy for the treatment of vitreous hemorrhage...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28226388/-can-anti-vegf-injections-cause-glaucoma-or-ocular-hypertension
#4
I Lanzl, K Kotliar
An increasing number of patients receive intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections with a high frequency for the treatment of neovascular macular disease. Since the volume of the vitreous body is temporarily increased by the injection of the substances, a short-term intraocular pressure increase after the introduction of the substance is not uncommon. However, there are more and more reports indicating that multiple injections may lead to a long-term increase in intraocular pressure...
February 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28186508/association-between-open-angle-glaucoma-and-neovascular-age-related-macular-degeneration-a-case-control-study
#5
C-C Hu, J-D Ho, H-C Lin, L-T Kao
PurposeTo investigate the relationship between previously diagnosed open-angle glaucoma (OAG) and neovascular age-related macular degeneration (AMD) using a routine insurance dataset.MethodsThis study retrieved data from the Taiwan Longitudinal Health Insurance Database 2005. We found 3282 patients with neovascular AMD as cases and 13 128 sex- and age-matched subjects without neovascular AMD as controls. Conditional logistic regressions were performed to evaluate the association of neovascular AMD with previously diagnosed OAG among the sampled patients...
February 10, 2017: Eye
https://www.readbyqxmd.com/read/28161925/the-use-of-microperimetry-to-detect-functional-progression-in-non-neovascular-age-related-macular-degeneration-a-systematic-review
#6
REVIEW
Evan N Wong, Avenell L Chew, William H Morgan, Praveen J Patel, Fred K Chen
We reviewed the current literature on the ability of microperimetry to detect non-neovascular age-related macular degeneration (AMD) disease progression. The index test was retinal sensitivity measurement assessed by microperimetry and comparators were other functional measures (best-corrected and low-luminance visual acuities, and fixation stability) and structural parameters [retinal thickness, choroidal thickness, and area of geographic atrophy (GA) determined by color fundus photographs, short-wave or near-infrared fundus autofluorescence]...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161916/the-pathway-from-genes-to-gene-therapy-in-glaucoma-a-review-of-possibilities-for-using-genes-as-glaucoma-drugs
#7
REVIEW
Teresa Borrás
Treatment of diseases with gene therapy is advancing rapidly. The use of gene therapy has expanded from the original concept of re-placing the mutated gene causing the disease to the use of genes to con-trol nonphysiological levels of expression or to modify pathways known to affect the disease. Genes offer numerous advantages over conventional drugs. They have longer duration of action and are more specific. Genes can be delivered to the target site by naked DNA, cells, nonviral, and viral vectors. The enormous progress of the past decade in molecular bi-ology and delivery systems has provided ways for targeting genes to the intended cell/tissue and safe, long-term vectors...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28161147/factors-associated-with-worsening-proliferative-diabetic-retinopathy-in-eyes-treated-with-panretinal-photocoagulation-or-ranibizumab
#8
Susan B Bressler, Wesley T Beaulieu, Adam R Glassman, Jeffrey G Gross, Lee M Jampol, Michele Melia, Mark A Peters, Michael E Rauser
PURPOSE: To compare rates and identify predictive factors for events that represent worsening of proliferative diabetic retinopathy (PDR) in eyes treated with panretinal photocoagulation (PRP) or ranibizumab. DESIGN: Randomized clinical trial (55 United States sites). PARTICIPANTS: Three hundred ninety-four study eyes from 305 adults with PDR, visual acuity (VA) 20/320 or better, and no history of PRP. INTERVENTION: Panretinal photocoagulation or intravitreous ranibizumab injections (0...
February 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28127658/inner-retinal-layer-change-in-glaucoma-patients-receiving-anti-vegf-for-neovascular-age-related-macular-degeneration
#9
Rafidah Saleh, Aashraya Karpe, Martin S Zinkernagel, Marion R Munk
PURPOSE: The purpose was to evaluate the effects of long-term anti-VEGF treatment on the retinal nerve fiber layer (RNFL) and retinal ganglion cell layer (RGCL) thickness for patients with neovascular AMD and glaucoma. METHODS: Medical records of respective patients who had received more than 15 anti-VEGF injections were reviewed. Initial and latest SD-OCT macular scans were segmented and changes of the RNFL and RGCL thickness at the four outer ETDRS quadrants were evaluated...
January 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28118203/evaluation-of-the-efficacy-and-safety-of-the-new-susanna-glaucoma-drainage-device-in-refractory-glaucomas-short-term-results
#10
Luis G Biteli, Tiago S Prata, Carolina P B Gracitelli, Fábio N Kanadani, Flávia Villas Boas, Marcelo Hatanaka, Augusto Paranhos Junior
PURPOSE: To assess the efficacy and safety of the new Susanna glaucoma drainage device (SGDD) in patients with neovascular and refractory glaucomas. MATERIALS AND METHODS: In this prospective study, patients with neovascular glaucoma or refractory glaucomas (defined as eyes with previous trabeculectomy failure) were enrolled. All eyes had to have intraocular pressure (IOP) above 21 mm Hg despite maximum tolerated topical medication, or recent documentation of anatomic and/or functional progression...
January 23, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28110950/vancomycin-associated-hemorrhagic-occlusive-retinal-vasculitis-clinical-characteristics-of-36-eyes
#11
Andre J Witkin, David F Chang, J Michael Jumper, Steve Charles, Dean Eliott, Richard S Hoffman, Nick Mamalis, Kevin M Miller, Charles C Wykoff
PURPOSE: To expand understanding of presentation, diagnosis, and outcomes of hemorrhagic occlusive retinal vasculitis (HORV). DESIGN: Retrospective case series. PARTICIPANTS: Thirty-six eyes of 23 patients. METHODS: The American Society of Cataract and Refractive Surgery (ASCRS) and the American Society of Retina Specialists (ASRS) formed a joint task force to define clinical characteristics of HORV and to study its prevalence, cause, treatment, and outcomes...
January 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28063082/vitrectomy-for-complications-of-proliferative-diabetic-retinopathy-in-young-adults-clinical-features-and-surgical-outcomes
#12
Chu-Hsuan Huang, Yi-Ting Hsieh, Chung-May Yang
PURPOSE: To investigate the clinical manifestations and surgical results after vitrectomy for proliferative diabetic retinopathy (PDR) in young patients. METHODS: Clinical features of patients between 18 to 40 years old who received vitrectomy for PDR between January 2009 and January 2015 were retrospectively reviewed. Those older than 40 years who received vitrectomy for PDR during the same period were retrospectively enrolled and compared as the control group...
January 6, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28053503/assessment-of-ischemia-in-acute-central-retinal-vein-occlusion-from-inner-retinal-reflectivity-on-spectral-domain-optical-coherence-tomography
#13
David J Browning, Omar S Punjabi, Chong Lee
PURPOSE: To determine the relationship between different spectral domain optical coherence tomography (SD-OCT) signs of retinal ischemia in acute central retinal vein occlusion (CRVO) and whether they predict anterior segment neovascularization (ASNV). DESIGN: Retrospective, observational study. SUBJECTS: Thirty-nine consecutive patients with acute CRVO and 12 months of follow-up. METHODS: We graded baseline SD-OCTs for increased reflectivity of the inner retina, loss of definition of inner retinal layers, presence of a prominent middle-limiting membrane (p-MLM) sign, and presence of paracentral acute middle maculopathy (PAMM)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28034080/ocular-salvage-and-vision-preservation-using-a-topotecan-based-regimen-for-advanced-intraocular-retinoblastoma
#14
Rachel C Brennan, Ibrahim Qaddoumi, Shenghua Mao, Jianrong Wu, Catherine A Billups, Clinton F Stewart, Mary Ellen Hoehn, Carlos Rodriguez-Galindo, Matthew W Wilson
Purpose To evaluate topotecan-based therapy for advanced intraocular retinoblastoma. Patients and Methods Twenty-seven patients with bilateral retinoblastoma (male patients, n = 14; median age, 8.4 months) received chemotherapy: two courses of topotecan plus vincristine followed by three alternating administrations of carboplatin and vincristine for two courses and topotecan plus vincristine for one course, with optional periocular carboplatin. Focal therapy was applied after cycle 2. Event-free survival was defined as avoidance of external-beam radiotherapy (EBRT) and enucleation...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28003975/preoperative-evaluation-and-outcome-of-corneal-transplantation-for-limbal-dermoids-a-ten-year-follow-up-study
#15
Meng Xin, Yue-Rong Gong, Shan-Hao Jiang, Chun-Hua Dai, Su-Xia Li, Wei-Yun Shi
AIM: To summarize preoperative evaluation and outcome of corneal transplantation for limbal dermoids for ten years. METHODS: Eighty-five patients diagnosed with limbal dermoids and treated with corneal transplantation were analyzed retrospectively. All patients were further divided into two groups according to absence or presence of neovascularization surrounding the dermoids in the corneal stroma. Eighty-two eyes were treated with tumor excision combined with partial lamellar sclerokeratoplasty, and the other three eyes were performed by penetrating keratoplasty...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28000166/current-perspectives-on-the-use-of-anti-vegf-drugs-as-adjuvant-therapy-in-glaucoma
#16
REVIEW
Vanessa Andrés-Guerrero, Lucía Perucho-González, Julián García-Feijoo, Laura Morales-Fernández, Federico Saenz-Francés, Rocío Herrero-Vanrell, Luis Pablo Júlvez, Vicente Polo Llorens, José María Martínez-de-la-Casa, Anastasios-Georgios P Konstas
The approval of one of the first anti-vascular endothelial growth factor (VEGF) agents for the treatment of neovascular age-related macular degeneration one decade ago marked the beginning of a new era in the management of several sight-threatening retinal diseases. Since then, emerging evidence has demonstrated the utility of these therapies for the treatment of other ocular conditions characterized by elevated VEGF levels. In this article we review current perspectives on the use of anti-VEGF drugs as adjuvant therapy in the management of neovascular glaucoma (NVG)...
February 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27998430/-expression-of-erythropoietin-in-neovascular-glaucoma-and-its-role-in-the-angiogenesis-in-vitro
#17
Y Sun, Y Q Xing, W Y Guan
Objective: To explore the expression of erythropoietin (EPO) in neovascular glaucoma (NVG) and its role in the angiogenesis in vitro. Methods: The levels of EPO in aqueous humor and vitreous body of NVG patients (10 cases) and non-NVG patients (10 cases) were detected by enzyme-linked immunosorbent assay (ELISA). Human umbilical vein endothelial cells (HUVECs) were used as the research object, and were divided into EPO 0.1, 1, 10 U/ml group according to EPO concentration, on the basis of treatment of HUVECs cells with 10 ng/ml vascular endothelial growth factor (VEGF)...
December 13, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27990117/a-case-of-proliferative-diabetic-retinopathy-with-hiv-infection-in-which-haart-possibly-influenced-the-prognosis-of-visual-function
#18
Takakuni Kitagaki, Takaki Sato, Junko Hirai, Daisaku Kimura, Keigo Kakurai, Masanori Fukumoto, Kensuke Tajiri, Takatoshi Kobayashi, Teruyo Kida, Shota Kojima, Tsunehiko Ikeda
BACKGROUND: We report on a patient with proliferative diabetic retinopathy (PDR) and human immunodeficiency virus (HIV) infection who exhibited extremely active PDR followed by a rapid onset of blindness in the right eye. The progression of visual disturbance in the patient's left eye was slowed after starting highly active anti-retroviral therapy (HAART), and vision in that eye was rescued after vitrectomy. CASE REPORT: A 72-year-old male developed pneumocystis carinii pneumonia stemming from an HIV infection and began HAART at the Department of Hematology, Osaka Medical College, Takatsuki City, Japan...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27984550/long-term-anatomical-and-functional-outcomes-following-vitrectomy-for-advanced-coats-disease
#19
Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas, Serra Arf
PURPOSE: To assess the long-term anatomical and functional results of vitreoretinal surgery in patients with advanced Coats disease. METHODS: Retrospective analysis of 23 patients who underwent 23-gauge pars plana vitrectomy combined with transscleral cryotherapy, laser photocoagulation, and intraocular tamponade between 2005 and 2014 and had a follow-up of at least 1 year. The primary outcomes were mean visual acuity and anatomical success. RESULTS: The average age at the time of surgery was 8...
December 14, 2016: Retina
https://www.readbyqxmd.com/read/27915382/high-intensity-focused-ultrasound-treatment-in-patients-with-refractory-glaucoma
#20
Giuseppe Giannaccare, A Vagge, C Gizzi, A Bagnis, S Sebastiani, C Del Noce, M Fresina, C E Traverso, E C Campos
PURPOSE: To assess the safety and efficacy of ultrasound coagulation of the ciliary body in refractory glaucoma. METHODS: This prospective multicenter interventional study was conducted in two Italian university-affiliated glaucoma centers: St. Orsola-Malpighi Teaching Hospital (Bologna, Italy) and University Eye Clinic of Genoa (Genoa, Italy). The main inclusion criterion was the diagnosis of glaucoma with a baseline intraocular pressure (IOP) ≥ 21 mmHg while on maximum topical and systemic medical hypotensive treatment...
March 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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