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Neovascular glaucoma

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https://www.readbyqxmd.com/read/29044062/changing-epidemiology-of-neovascular-glaucoma-from-2002-to-2012-at-king-khaled-eye-specialist-hospital-saudi-arabia
#1
Abdullah Al-Bahlal, Rajiv Khandekar, Khalid Al Rubaie, Tariq Alzahim, Deepak P Edward, Igor Kozak
PURPOSE: The aim is to present the incidence and determinants of neovascular glaucoma (NVG) in Saudi Arabia. METHODS: A retrospective review of NVG cases (2002-2012) was included to estimate the incidence. The determinants included gender, age, comorbidities, lens status, type of NVG, and visual acuity on presentation. The impact of antiangiogenic therapy on NVG incidence was studied. RESULTS: We studied 597 eyes with NVG. The incidence was 6...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29033535/differential-association-of-elevated-inflammatory-cytokines-with-postoperative-fibrous-proliferation-and-neovascularization-after-unsuccessful-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#2
Shigeo Yoshida, Yoshiyuki Kobayashi, Shintaro Nakao, Yukio Sassa, Toshio Hisatomi, Yasuhiro Ikeda, Yuji Oshima, Toshihiro Kono, Tatsuro Ishibashi, Koh-Hei Sonoda
BACKGROUND: Pars plana vitrectomy is the only treatment for advanced proliferative diabetic retinopathy (PDR). However, vitrectomy is not always successful despite current progress in vitreoretinal surgical techniques. The aim of our study was to investigate whether the vitreal concentrations of MCP-1, IL-6, IL-8, and VEGF are elevated after unsuccessful vitrectomy in patients with PDR and to investigate whether the altered levels of these cytokines are associated with the cause for the reoperation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29022296/efficacy-and-safety-of-intracameral-bevacizumab-for-treatment-of-neovascular-glaucoma
#3
Jun Young Ha, Tae Hee Lee, Mi Sun Sung, Sang Woo Park
PURPOSE: To evaluate the long-term efficacy and safety of intracameral bevacizumab in patients with neovascular glaucoma. METHODS: This retrospective study included 26 eyes of 26 neovascular glaucoma patients who received intracameral bevacizumab injection between January 2013 and May 2015, and were followed-up for at least 1 year. All patients were treated with topical and/or systemic intraocular pressure (IOP)-lowering medications, intracameral bevacizumab, and panretinal photocoagulation (PRP)...
August 26, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29016456/new-ultra-wide-field-angiographic-grading-scheme-for-radiation-retinopathy-after-iodine-125-brachytherapy-for-uveal-melanoma
#4
Tara A McCannel, EunAh Kim, Mitchell Kamrava, James Lamb, Joseph Caprioli, Dong Yang, Colin A McCannel
PURPOSE: Radiation retinopathy remains incompletely characterized and may cause severe vision loss. Ultra-wide-field fluorescein angiography provides a pan-fundus view of vascular alterations caused by radiation treatment and may predict visual and ocular outcomes. We have developed a grading scheme to describe pan-fundus severity and to predict the progression of radiation retinopathy in patients treated for uveal melanoma with iodine-125 brachytherapy. METHODS: A retrospective review of patients treated with standard iodine-125 brachytherapy for uveal melanoma at the Ophthalmic Oncology Center at the University of California, Los Angeles, who had undergone both baseline and postbrachytherapy ultra-wide-field fluorescein angiography...
October 6, 2017: Retina
https://www.readbyqxmd.com/read/28992424/long-term-outcome-of-intravitreal-bevacizumab-followed-by-ahmed-valve-implantation-in-the-management-of-neovascular-glaucoma
#5
Rajen Tailor, Matt T Kinsella, Jonathan C Clarke
BACKGROUND: To report the outcome of intravitreal Bevacizumab followed by Ahmed valve implantation in the management of neovascular glaucoma in a patient group with extended follow-up. METHODS: The records of 16 patients (18 eyes) with neovascular glaucoma refractory to medical therapy who presented to a single surgeon between 2006-2008 were reviewed. Patients received pan-retinal photocoagulation and then intravitreal Bevacizumab followed by Ahmed valve implantation...
October 9, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28986592/sustaining-intravitreal-residence-with-l-arginine-peptide-conjugated-nanocarriers
#6
Hao Li, Wenzhong Liu, Christine M Sorenson, Nader Sheibani, Daniel M Albert, Thulani Senanayake, Serguei Vinogradov, Jack Henkin, Hao F Zhang
Purpose: Intravitreal injection of antiangiogenic agents is becoming a standard treatment for neovascular retinal diseases. Sustained release of therapeutics by injecting colloidal carriers is a promising approach to reduce the injection frequency, which reduces treatment burdens and the risk of complications on patients. Such sustained release often requires carriers to have micrometer-scale dimension that, however, can potentially promote glaucoma and inflammation. Small, polycationic particles can be immobilized in vitreous through multiple cooperative ionic interactions with hyaluronic acid of the vitreous interior, but such particles are generally toxic...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28944413/longer-term-baerveldt-to-trabectome-glaucoma-surgery-comparison-using-propensity-score-matching
#7
Tigran Kostanyan, Tarek Shazly, Kevin B Kaplowitz, Steven Z Wang, Sushma Kola, Eric N Brown, Nils A Loewen
PURPOSE: To apply propensity score matching to compare Baerveldt glaucoma drainage implant (BGI) to Trabectome-mediated ab interno trabeculectomy (AIT). Recent data suggests that AIT can produce results similar to BGI which is traditionally reserved for more severe glaucoma. METHODS: BGI and AIT patients with at least 1 year of follow-up were included. The primary outcome measures were intraocular pressure (IOP), number of glaucoma medications, and a Glaucoma Index (GI) score...
September 25, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28936054/patterns-of-intermediate-uveitis-in-children-presenting-at-a-tertiary-eye-care-center-in-south-india
#8
Radha Annamalai, Jyotirmay Biswas
PURPOSE: To study the patterns of intermediate uveitis in the pediatric age group in a referral eye care center in South India. METHODS: This is a study of twenty consecutive patients under 16 years of age with intermediate uveitis, conducted at a tertiary referral center. Numerous variables were assessed, including age and gender distribution, laboratory data, the presence of systemic diseases, onset and course of ocular inflammation, clinical features, their complications, therapeutic strategies with their outcomes, remission, final visual acuity (VA), and characteristics associated with poor visual outcome...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928981/association-of-neovascular-glaucoma-with-risk-of-stroke-a-population-based-cohort-study
#9
Cheng-Wen Su, Yue-Cune Chang, Cheng-Li Lin, Hsin-Yi Chen
Neovascular glaucoma (NVG), caused by ocular ischemia, is a serious ocular disease complicated by intractably increased intraocular pressure. Cerebrovascular accidents are classified into ischemic and hemorrhagic stroke. Based on the similar pathogenic mechanisms of NVG and ischemic stroke, we investigated the relationship between NVG and stroke by using a nationally representative sample. This study included 416 NVG patients and 4160 controls. Medical comorbidities were also evaluated. The cumulative incidence of ischemic stroke was 15...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28924338/neovascular-glaucoma-a-retrospective-review-from-a-tertiary-eye-care-center-in-mexico
#10
Gabriel Lazcano-Gomez, Jeffrey R Soohoo, Anne Lynch, Levi N Bonell, Karina Martinez, Mauricio Turati, Roberto Gonzalez-Salinas, Jesus Jimenez-Roman, Malik Y Kahook
AIM: To describe the demographic characteristics, ocular comorbidities, and clinical outcomes of patients with neovascular glaucoma (NVG) and to determine the number of patients who returned for a follow-up eye examination. MATERIALS AND METHODS: We examined the clinical data of patients with NVG, who attended a glaucoma clinic between July 2010 and November 2014. We collected information on the demographic characteristics of the patients to include the level of education, ocular comorbidities, NVG stage, visual acuity, glaucoma medications, intraocular pressure (IOP), and the number of patients who had a follow-up ocular examination at month 1, 3, 6, and 12...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28916115/-retinal-vein-occlusions
#11
REVIEW
A Pierru, J-F Girmens, E Héron, M Paques
Retinal venous occlusions comprise central retinal vein occlusion, hemiretinal vein occlusions, and branch retinal vein occlusions. They are associated with arterial hypertension and glaucoma. Retinal vein occlusions occur more frequently in males, at a median age of 55. The pathogenesis of retinal venous occlusions remains obscure. The clinical presentation of the disease is variable. In most cases, there is a unilateral visual loss over days with a painless, white and quiet eye. However, retinal venous occlusions may also present as an abrupt and profound loss of vision, or be asymptomatic...
October 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28911993/ocular-manifestations-of-familial-transthyretin-amyloidosis
#12
Margaret M Reynolds, Kevin K Veverka, Morie A Gertz, Angela Dispenzieri, Steven R Zeldenrust, Nelson Leung, Jose S Pulido
PURPOSE: Among patients with familial amyloidosis, mutation in the transthyretin (TTR) protein is the most common type. Patients with TTR amyloidosis have been noted to have ocular, especially vitreous, involvement. In this report, an analysis of the types and frequency of ocular manifestations in TTR amyloidosis is presented. DESIGN: Observational case series. METHODS: Two hundred and sixty-three patients who presented to Mayo Clinic with TTR amyloidosis between January 1, 1970, and November 1, 2014, consented to be included in the Mayo Clinic amyloidosis database maintained by the Department of Hematology...
September 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28906020/diagnostic-impact-of-anterior-segment-angiography-of-limbal-stem-cell-insufficiency-in-pax6-related-aniridia
#13
Barbara Käsmann-Kellner, Lorenz Latta, Fabian Fries, Arne Viestenz, Berthold Seitz
BACKGROUND: PAX6 is a master gene of ocular development and postnatal ocular equilibrium. Congenital aniridia is the hallmark of PAX6 gene haploinsufficiency (Chr. 11 p. 13), but PAX6-associated aniridia is a profound, progressive pan-ocular developmental disorder often leading to blindness. Limbal stem cell insufficiency and corneal findings in PAX6 syndrome: There is congenital visual impairment with advancing loss of vision mainly due to secondary glaucoma and to corneal blindness caused by limbal stem cell insufficiency (LSCI)...
September 14, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28903963/predictors-of-radio-induced-visual-impairment-after-radiosurgery-for-uveal-melanoma
#14
Carmen Rosaria Gigliotti, Giulio Modorati, Maura Di Nicola, Claudio Fiorino, Lucia Alessia Perna, Elisabetta Miserocchi, Alberto Franzin, Piero Picozzi, Angelo Bolognesi, Pietro Mortini, Antonella Del Vecchio, Riccardo Calandrino
AIMS: The aim of the present work is to assess the main predictors of the most clinically relevant radio-induced effects after Gamma Knife stereotactic radiosurgery (GKRS) for uveal melanoma (UM). MATERIALS AND METHODS: Medical records and three-dimensional dosimetry data of critical structures of 66 patients were retrospectively reviewed. Cox's proportional hazard model was used to identify clinical and dosimetric variables as independent risk factor for GKRS-related complications...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28867543/clinical-outcomes-of-hypofractionated-radiation-therapy-for-choroidal-metastases-symptom-palliation-tumor-control-and-survival
#15
Ezra Hahn, Normand Laperriere, Hatem Krema, Juan P Velazquez-Martin, Sohel Somani, John Waldron, Rand Simpson, David Payne, Caroline Chung
PURPOSE: External beam radiation therapy (RT) is an effective palliative treatment for patients with choroidal metastases and is aimed at preserving vision and obtaining local tumor control. Delivery of 30 to 40 Gy in 2-Gy daily fractions is a standard approach at many centers. This study reports the outcomes of a hypofractionated schedule of 20 Gy in 5 fractions in this palliative setting. METHODS AND MATERIALS: We conducted a retrospective review of patients who were treated with RT (20 Gy in 5 fractions) for choroidal metastases between January 1999 and November 2012...
June 29, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28858157/primary-trabeculectomy-outcomes-by-glaucoma-fellows-in-a-tertiary-hospital-in-brazil
#16
Ricardo Yuji Abe, Leonardo Seidi Shigueoka, José Paulo Cabral Vasconcellos, Vital Paulino Costa
PURPOSE: To examine outcomes of trabeculectomy with mitomycin C for uncontrolled glaucoma when performed by glaucoma trainee surgeons. METHODS: Retrospective case series of patients who underwent trabeculectomy with mitomycin C. Primary outcome was to assess the rate of failure, which was defined as intraocular pressure in two consecutive visits greater than 18 or lower than 5 mm Hg or IOP reduction <30% from baseline, additional glaucoma surgery, or loss of light perception...
August 28, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28858093/surgical-treatment-of-neovascular-glaucoma-with-ex-press-glaucoma-shunt-case-report
#17
Teng-Chieh Yu, Gow-Lieng Tseng, Chun-Chen Chen, Shiow-Wen Liou
RATIONALE: Neovascular glaucoma (NVG) is one of the most aggressive types of glaucoma, and its abnormal fibrovascular tissue growth on the iris and trabecular meshwork may create difficulties to control the intraocular pressure (IOP) and perform the operation such as trabeculectomy. PATIENT CONCERNS: Ex-PRESS glaucoma shunt has been introduced to serve as one alternative operation for glaucoma, and is thought to have the potential advantage of being less traumatic than traditional trabeculectomy...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28820164/cyclophotocoagulation-induced-sympathetic-ophthalmia-in-a-coats-disease-patient-supported-by-histopathology-and-immunohistochemistry
#18
Pritam Bawankar, Dipankar Das, Shahinur Tayab, Ganesh Chandra Kuri, Jnanankar Medhi, Manabjyoti Barman, Ronel Soibam, Harsha Bhattacharjee, Panna Deka, Diva Kant Misra, Shriya Dhar
We describe a case of a 13-year-old male patient of Coats' disease who developed sympathetic ophthalmia (SO) following contact diode laser cyclophotocoagulation. There was no history of invasive surgery or any perforating injuries preceding cyclodestructive therapy. The eye had neovascular glaucoma secondary to Coats' disease, which was treated once with contact cyclophotocoagulation. Subsequently, the intraocular pressure slowly decreased, and the eye became phthisical. Intraocular inflammation developed in the fellow eye and SO was suspected, which was confirmed by characteristic findings seen on fluorescein angiography...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28815088/use-of-anti-vegf-agents-in-glaucoma-surgery
#19
REVIEW
Mark Slabaugh, Sarwat Salim
A number of antivascular endothelial growth factor agents are currently available to treat various ocular conditions. These agents have similar, but distinct, biologic qualities and have been explored in the management of neovascular glaucoma and in glaucoma surgery. Several different delivery methods are described, and because these medications are routinely given as intraocular injections, some benefits over traditional antifibrotic medications when used in glaucoma surgery are noted. These agents effectively induce regression of anterior segment neovascularization and facilitate initial surgical management of neovascular glaucoma, but the long-term outcome of this condition remains dependent on definitive management of the underlying process...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28807635/sustained-benefits-of-ranibizumab-with-or-without-laser-in-branch-retinal-vein-occlusion-24-month-results-of-the-brighter-study
#20
Ramin Tadayoni, Sebastian M Waldstein, Francesco Boscia, Heinrich Gerding, Margarita Gekkieva, Elizabeth Barnes, Ayan Das Gupta, Andreas Wenzel, Ian Pearce
PURPOSE: To evaluate the long-term (24-month) efficacy and safety of ranibizumab 0.5 mg administered pro re nata (PRN) with or without laser using an individualized visual acuity (VA) stabilization criteria in patients with visual impairment due to macular edema secondary to branch retinal vein occlusion (BRVO). DESIGN: Phase IIIb, open-label, randomized, active-controlled, 3-arm, multicenter study. PARTICIPANTS: A total of 455 patients. METHODS: Patients were randomized (2:2:1) to ranibizumab 0...
August 11, 2017: Ophthalmology
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