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https://www.readbyqxmd.com/read/28646641/do-large-mergers-increase-or-decrease-the-productivity-of-pharmaceutical-r-d
#1
Michael S Ringel, Michael K Choy
There is current uncertainty regarding the effects of mergers on pharmaceutical R&D productivity, with various mechanisms reported by which mergers could either help or harm R&D, and mixed empirical findings in prior analyses. Here, we present an analysis that is novel in several ways: we use downstream measures of R&D productivity, account for both inputs and outputs in our calculations, and use a self-controlled design. We find that recent large pharmaceutical mergers are associated with statistically significant increases in R&D productivity...
June 21, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28646348/tau-induced-ca-2-calmodulin-dependent-protein-kinase-iv-activation-aggravates-nuclear-tau-hyperphosphorylation
#2
Yu-Ping Wei, Jin-Wang Ye, Xiong Wang, Li-Ping Zhu, Qing-Hua Hu, Qun Wang, Dan Ke, Qing Tian, Jian-Zhi Wang
Hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with Alzheimer's disease (AD). However, the mechanism underlying tau hyperphosphorylation is not fully understood. Here, we demonstrated that exogenously expressed wild-type human tau40 was detectable in the phosphorylated form at multiple AD-associated sites in cytoplasmic and nuclear fractions from HEK293 cells. Among these sites, tau phosphorylated at Thr205 and Ser214 was almost exclusively found in the nuclear fraction at the conditions used in the present study...
June 23, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28645063/assessing-phosphatidylethanol-peth-levels-reflecting-different-drinking-habits-in-comparison-to-the-alcohol-use-disorders-identification-test-c-audit-c
#3
Alexandra Schröck, Friedrich M Wurst, Natasha Thon, Wolfgang Weinmann
In addition to monitoring problematic or harmful alcohol consumption, drinking experiments indicated the potential of phosphatidylethanols (PEth) in abstinence monitoring. To date, no profound evaluation of thresholds for the differentiation of abstinence from moderate drinking and for detection of excessive consumption based on PEth homologues exists. Investigations with a large group of healthy volunteers (n=300) were performed to establish PEth reference values reflecting different drinking habits. Blood samples were analyzed for PEth 16:0/18:1 and 16:0/18:2 by online-SPE-LC-MS/MS method...
June 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28644703/the-relation-of-protective-factors-to-deliberate-self-harm-among-african-american-adults-moderating-roles-of-gender-and-sexual-orientation-identity
#4
Lindsey T Davis, Nicole H Weiss, Matthew T Tull, Kim L Gratz
BACKGROUND: Few studies have examined correlates of deliberate self-harm (DSH) among African-Americans. Moreover, most research on the correlates of DSH in general has focused on risk factors rather than protective factors. AIMS: This study examined differences in perceived social support, religiosity (both spirituality and church attendance) and overall life satisfaction between African-Americans with and without a history of DSH, as well as the moderating roles of gender and sexual orientation in these relations...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28643152/the-impact-of-speed-of-play-in-gambling-on-psychological-and-behavioural-factors-a-critical-review
#5
REVIEW
Andrew Harris, Mark D Griffiths
Conceptually, there is a common association between gambling games with fast speeds of play and problem gambling. This relationship however, is largely correlational in nature, which comes at the expense of carefully controlled empirical investigation. Research that does exist aimed towards investigating the impact of gambling speeds on psychological and behavioural factors, is in its relative infancy, and the research possesses disparate methodologies and variables of interest. The aims of the current review is therefore to evaluate and summarise the existing body of evidence relating to speed of play in gambling, as well as discuss how this evidence can be used to inform harm minimisation approaches aimed at facilitating self-control during gambling...
June 22, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28642720/depressive-symptomatology-among-norwegian-adolescent-boys-and-girls-the-patient-health-questionnaire-9-phq-9-psychometric-properties-and-correlates
#6
Jasmina Burdzovic Andreas, Geir S Brunborg
This study explored the potential contribution of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV)-based Patient Health Questionnaire-9 item (PHQ-9) instrument to the developmental epidemiology research in Norway, by examining depressive symptoms in a school sample of adolescents (N = 846). The average PHQ-9 scores were 6.89 (SD = 5.13) for girls, and 4.57 (SD = 3.98) for boys; 8.5% of girls and 2.6% of boys were classified into the originally proposed categories indicative of Major Depressive Disorder (MDD; PHQ-9 scores ≥ 15)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28642277/adipose-tissue-macrophages-develop-from-bone-marrow-independent-progenitors-in-xenopus-laevis-and-mouse
#7
Syed F Hassnain Waqas, Anna Noble, Anh C Hoang, Grace Ampem, Manuela Popp, Sarah Strauß, Matthew Guille, Tamás Röszer
ATMs have a metabolic impact in mammals as they contribute to metabolically harmful AT inflammation. The control of the ATM number may have therapeutic potential; however, information on ATM ontogeny is scarce. Whereas it is thought that ATMs develop from circulating monocytes, various tissue-resident Mϕs are capable of self-renewal and develop from BM-independent progenitors without a monocyte intermediate. Here, we show that amphibian AT contains self-renewing ATMs that populate the AT before the establishment of BM hematopoiesis...
June 22, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28641479/norms-and-normalisation-understanding-lesbian-gay-bisexual-transgender-and-queer-youth-suicidality-and-help-seeking
#8
Elizabeth McDermott, Elizabeth Hughes, Victoria Rawlings
Young people who identify as lesbian, gay, bisexual, and queer transgender have elevated rates of suicidality. Despite the increased risk, there is a paucity of research on lesbian, gay, bisexual, transgender and queer help-seeking and suicidality. We report on a UK sequential exploratory, two-stage, mixed-method study. Stage 1 involved 29 online and face-to-face semi-structured interviews with lesbian, gay, bisexual, transgender and queer youth aged 16-25 years old. Stage 2 utilised an online youth questionnaire employing a community-based sampling strategy (n = 789)...
June 23, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28641217/the-aggressor-at-the-mirror-psychiatric-correlates-of-deliberate-self-harm-in-male-prison-inmates
#9
N Verdolini, A Murru, L Attademo, R Garinella, I Pacchiarotti, C Del Mar Bonnin, L Samalin, L Pauselli, M Piselli, A Tamantini, R Quartesan, A F Carvalho, E Vieta, A Tortorella
BACKGROUND: Deliberate self-harm (DSH) causes important concern in prison inmates as it worsens morbidity and increases the risk for suicide. The aim of the present study is to investigate the prevalence and correlates of DSH in a large sample of male prisoners. METHODS: A cross-sectional study evaluated male prisoners aged 18+ years. Current and lifetime psychiatric diagnoses were assessed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders - DSM-IV Axis I and Axis II Disorders and with the Addiction Severity Index-Expanded Version...
April 14, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28639320/diet-physical-activity-and-behavioural-interventions-for-the-treatment-of-overweight-or-obese-adolescents-aged-12-to-17-years
#10
REVIEW
Lena Al-Khudairy, Emma Loveman, Jill L Colquitt, Emma Mead, Rebecca E Johnson, Hannah Fraser, Joan Olajide, Marie Murphy, Rochelle Marian Velho, Claire O'Malley, Liane B Azevedo, Louisa J Ells, Maria-Inti Metzendorf, Karen Rees
BACKGROUND: Adolescent overweight and obesity has increased globally, and can be associated with short- and long-term health consequences. Modifying known dietary and behavioural risk factors through behaviour changing interventions (BCI) may help to reduce childhood overweight and obesity. This is an update of a review published in 2009. OBJECTIVES: To assess the effects of diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years...
June 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28637535/routine-hospital-management-of-self-harm-and-risk-of-further-self-harm-propensity-score-analysis-using-record-based-cohort-data
#11
S Steeg, R Emsley, M Carr, J Cooper, N Kapur
BACKGROUND: The care received by people presenting to hospital following self-harm varies and it is unclear how different types of treatment affect risk of further self-harm. METHOD: Observational cohort data from the Manchester Self-Harm Project, UK, included 16 456 individuals presenting to an Emergency Department with self-harm between 2003 and 2011. Individuals were followed up for 12 months. We also used data from a smaller cohort of individuals presenting to 31 hospitals in England during a 3-month period in 2010/2011, followed up for 6 months...
June 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28637073/-complementary-and-alternative-medicine-in-oncology-what%C3%A2-makes-sense
#12
Axel Eustachi, Dieter Melchart
The basis of any complementary therapy should be the recommendation of a healthy lifestyle (diet, nutrition, exercise, stress-reduction), and appropriate self-help techniques (e. g. thermotherapy, herbal OTC-products) aimed at releasing the patients' most debilitating symptoms. For therapy-resistant or strong symptoms, more invasive interventions or medical treatments with an acceptable evidence base can be used (e. g. acupuncture for cancer pain, herbal prescriptions). The effects of any complementary intervention should be controlled for a period of six weeks after its administration...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28636575/the-temperament-and-character-traits-in-patients-with-major-depressive-disorder-and-bipolar-affective-disorder-with-and-without-suicide-attempt
#13
Anamarija Petek Erić, Ivan Erić, Mario Ćurković, Katarina Dodig-Ćurković, Kristina Kralik, Vlatka Kovač, Pavo Filaković
BACKGROUND: Suicide and mood disorders (especially major depressive disorder (MDD) and bipolar affective disorder (BD)) represent a significant global health burden. Major depressive disorder and bipolar affective disorder have been associated with increased risk for suicide. Some specific suicide risk factors might be found in underlying individual personality traits. Specific personality features may predispose an individual to mood disorders (MDD or BD) hence increased suicide risk...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28636204/aerobic-exercise-training-for-adults-with-fibromyalgia
#14
REVIEW
Julia Bidonde, Angela J Busch, Candice L Schachter, Tom J Overend, Soo Y Kim, Suelen M Góes, Catherine Boden, Heather Ja Foulds
BACKGROUND: Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for people with fibromyalgia that will replace the "Exercise for treating fibromyalgia syndrome" review first published in 2002. OBJECTIVES: • To evaluate the benefits and harms of aerobic exercise training for adults with fibromyalgia• To assess the following specific comparisons ० Aerobic versus control conditions (eg, treatment as usual, wait list control, physical activity as usual) ० Aerobic versus aerobic interventions (eg, running vs brisk walking) ० Aerobic versus non-exercise interventions (eg, medications, education) We did not assess specific comparisons involving aerobic exercise versus other exercise interventions (eg, resistance exercise, aquatic exercise, flexibility exercise, mixed exercise)...
June 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28633634/the-development-and-appraisal-of-a-tool-designed-to-find-patients-harmed-by-falsely-labelled-falsified-counterfeit-medicines
#15
Marija Anđelković, Einar Björnsson, Virgilio De Bono, Nenad Dikić, Katleen Devue, Daniel Ferlin, Miroslav Hanževački, Freyja Jónsdóttir, Mkrtich Shakaryan, Sabine Walser
BACKGROUND: Falsely labelled, falsified (counterfeit) medicines (FFCm's) are produced or distributed illegally and can harm patients. Although the occurrence of FFCm's is increasing in Europe, harm is rarely reported. The European Directorate for the Quality of Medicines & Health-Care (EDQM) has therefore coordinated the development and validation of a screening tool. METHODS: The tool consists of a questionnaire referring to a watch-list of FFCm's identified in Europe, including symptoms of their use and individual risk factors, and a scoring form...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28629356/lifestyle-and-income-related-inequality-in-health-in-south-africa
#16
Alfred Kechia Mukong, Corne Van Walbeek, Hana Ross
BACKGROUND: Many low- and middle-income countries are experiencing an epidemiological transition from communicable to non-communicable diseases. This has negative consequences for their human capital development, and imposes a growing economic burden on their societies. While the prevalence of such diseases varies with socioeconomic status, the inequalities can be exacerbated by adopted lifestyles of individuals. Evidence suggests that lifestyle factors may explain the income-related inequality in self-reported health...
June 19, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28626858/antibiotics-for-acute-bronchitis
#17
REVIEW
Susan M Smith, Tom Fahey, John Smucny, Lorne A Becker
BACKGROUND: The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. OBJECTIVES: To assess the effects of antibiotics in improving outcomes and to assess adverse effects of antibiotic therapy for people with a clinical diagnosis of acute bronchitis. SEARCH METHODS: We searched CENTRAL 2016, Issue 11 (accessed 13 January 2017), MEDLINE (1966 to January week 1, 2017), Embase (1974 to 13 January 2017), and LILACS (1982 to 13 January 2017)...
June 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28625205/why-suicide-the-analysis-of-motives-for-self-harm
#18
Mohammed J Abbas, Mostafa A Mohanna, Tarig A Diab, Millicent Chikoore, Michael Wang
BACKGROUND: There is a gap in understanding the meaning and motives behind suicidal behaviour. Using the Ideal Type methodology, Jean Baechler systematically examined the internal logic of suicidal and self-harming behaviours. He developed a typology of eleven typical meanings/motives: Flight, Grief, Self-punishment, Vengeance, Crime, Blackmail, Appeal, Sacrifice, Transfiguration, Ordeal and Game. AIMS: To develop and validate a standardized instrument to measure the motives/meanings of suicidal and self-harming behaviours, using Baechler's typology...
June 19, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/28625189/influence-of-early-maladaptive-schemas-depression-and-anxiety-on-the-intensity-of-self-reported-cognitive-complaint-in-older-adults-with-subjective-cognitive-decline
#19
Caroline Tandetnik, Thierry Hergueta, Philippe Bonnet, Bruno Dubois, Catherine Bungener
BACKGROUND: Subjective cognitive decline (SCD) designates a self-reported cognitive decline despite preserved cognitive abilities. This study aims to explore, in older adults with SCD, the association between intensity of self-reported cognitive complaint and psychological factors including Young's early maladaptive schemas (EMSs) (i.e. enduring cognitive structures giving rise to beliefs about oneself and the world), as well as depression and anxiety. METHODS: Seventy-six subjects (69...
June 19, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28623806/prevalence-and-correlates-of-light-and-non-daily-smoking-in-brazil-results-from-a-nationwide-representative-survey
#20
Taynara Dutra Batista Formagini, Henrique Pinto Gomide, Jaime Perales, Fernando Antonio Basile Colugnati
BACKGROUND: The research of light (≤10 cigarettes per day) and non-daily smokers in developing countries including Brazil is scarce despite the high prevalence of these groups among smokers and health risks associated to low-level smoking. OBJECTIVE: To describe health and smoking characteristics of Brazilian adult light and non-daily smokers. METHODS: We analyzed data from the 2013 Brazilian National Health Research survey (n=48,282). RESULTS: The prevalence of current manufactured cigarette smoking in the total sample was 12...
June 10, 2017: Drug and Alcohol Dependence
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