keyword
https://read.qxmd.com/read/38288183/prevalence-and-distribution-of-developmental-defects-of-enamel-in-children-aged-12-15-years-in-fazilka-district-punjab-india-and-their-correlation-with-drinking-water-fluoride-level
#21
JOURNAL ARTICLE
Sandeep Sidhu, Navneet Kathuria, Bela Mahajan, Gagandeep K Sidhu, Karthikeyan Ramalingam
BACKGROUND AND OBJECTIVES: Dental fluorosis is a developmental disturbance of dental enamels, caused by successive exposures to high concentrations of fluoride during odontogenesis, leading to enamels with lower mineral content and increased porosity. The objective of the present study was to assess the prevalence and severity of developmental defects and their relationship to fluoride levels in drinking water.  Methods: Ten villages were selected from Fazilka district, Punjab, India...
December 2023: Curēus
https://read.qxmd.com/read/38288167/prevalence-of-dental-and-skeletal-fluorosis-among-school-children-in-rural-areas-of-ysr-kadapa-district-andhra-pradesh-india
#22
JOURNAL ARTICLE
Lavanya Sirigala, Pratibha Ramani, Priyadharshini G, Karthikeyan Ramalingam
Background Andhra Pradesh (AP) is one of the states in India found to have districts with endemic fluoride and YSR Kadapa district is one among them. Fluorosis is a well-known endemic disease affecting the hard tissues of the human body like teeth and bone and soft tissues like the kidneys, gastrointestinal system, nervous system, etc. Dental fluorosis is being proven as a biomarker for exposure to fluoride. This study evaluated the toxicity of fluoride in drinking water on the teeth (dental fluorosis) and on the bones (skeletal fluorosis) in YSR Kadapa district, AP...
December 2023: Curēus
https://read.qxmd.com/read/38250699/spatial-temporal-analysis-of-drinking-water-type-of-endemic-fluorosis-china-2009-2022
#23
JOURNAL ARTICLE
Lijun Zhao, Zhe Li, Mang Li, Hongna Sun, Wei Wei, Lin Gao, Qiaoshi Zhao, Yang Liu, Xiaohong Ji, Cheng Li, Jian Wang, Yanhui Gao, Junrui Pei
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Endemic fluorosis, caused by high fluoride levels in drinking water, has been a significant health issue in rural areas of China for many decades. WHAT IS ADDED BY THIS REPORT?: There has been a notable decline in the detection rate of dental fluorosis in children aged 8-12 years in drinking water fluorosis areas across the country from 2009 to 2022. While 14 provincial-level administrative divisions are classified as low-probability clusters, Tianjin remains classified as a high-probability cluster...
January 12, 2024: China CDC weekly
https://read.qxmd.com/read/38249196/role-of-fluoride-in-dentistry-a-narrative-review
#24
REVIEW
Nikhil Mankar, Saloni Kumbhare, Pradnya Nikhade, Joyeeta Mahapatra, Paridhi Agrawal
Fluoride has performed a central role in the growth over the last fifty years. This report examines the present state of knowledge about fluoride's involvement in preventing dental caries. In recent years, our knowledge of the development of dental caries and the manner of operation of fluoride has been shifted. Dental caries is a constant procedure for enamel demineralization and remineralization, and fluoride plays an important part in this action by acting at the plaque-enamel contact. Fluoride's major method of action is now recognized as posteruptive...
December 2023: Curēus
https://read.qxmd.com/read/38244175/exercise-alleviates-fluoride-induced-learning-and-memory-impairment-in-mice-role-of-mir-206-3p-and-preg
#25
JOURNAL ARTICLE
Lei Chai, Qiqi Cao, Ke Liu, Run Zhu, Hao Li, Yanghuan Yu, Jixiang Wang, Ruiyan Niu, Ding Zhang, Bo Yang, Mohammad Mehdi Ommati, Zilong Sun
Fluorosis decreases the learning and memory ability in humans and animals, while exercise can reduce the risk of cognitive decline. However, the effect of exercise on learning and memory in fluoride-exposed mice is unclear. For this purpose, in this study, mice were randomly allotted into four groups (16 mice per group, half male and half female): control group (group C), fluoride group (group F, 100 mg/L sodium fluoride (NaF)), exercise group (group E, treadmill exercise), and E plus F group (group EF, treadmill exercise, and 100 mg/L NaF)...
January 20, 2024: Biological Trace Element Research
https://read.qxmd.com/read/38244161/synthesis-characterization-and-evaluation-of-fluoride-removal-capacity-of-calcium-impregnated-euphorbia-neriifolia-carbon-ca-enc
#26
JOURNAL ARTICLE
Rajkumar Subramanium, Ezhaveni Sathiyamoorthi, Saravanakumar Rajagopal, Rajavenkatesh Krishnamoorthy, Jintae Lee, Lakshman Kumar A
Fluoride ions must be removed from drinking water in order to prevent fluorosis. Many conventional techniques have been examined for the defluoridation of water all over the world. As far as fluoride ions are concerned, adsorption is the most promising method for the removal of them from aqueous environments. In the present study, we aim to find out how well Euphorbia neriifolia plants can remove fluoride from water using activated and carbonized adsorbents. The Euphorbia neriifolia plant stem was pulverized, dried, and activated using calcium ions extracted from used eggshells collected nearby...
January 20, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38239163/potential-risk-of-dental-fluorosis-associated-with-different-baby-formulas-and-water-brands-marketed-in-spain
#27
JOURNAL ARTICLE
Sandra M Gallego-Reyes, Jaime A Cury, Amparo Pérez-Silva, Clara Serna-Muñoz, Icíar Fernández-Pizarro, Yolanda Martínez-Beneyto, Antonio J Ortiz-Ruiz
Despite efforts to promote breastfeeding, many babies aged <6 months receive only baby formula reconstituted with bottled water. The intake of high levels of fluoride during amelogenesis has been associated with hypomineralization of the tooth enamel, with aesthetic and mechanical repercussions. The objective of this study was to determine the potential risk of dental fluorosis associated with baby formulas marketed in Spain. We measured 26 baby formulas frequently consumed in Spain; 17 brands for babies aged <6 months, 5 for those aged >6 months, and 4 ready-to-use brands...
January 2024: Journal of Clinical Pediatric Dentistry
https://read.qxmd.com/read/38235820/a-comparative-evaluation-of-the-fluoride-content-in-commercially-available-infant-formulae-in-india-an-in-vitro-study
#28
JOURNAL ARTICLE
Asha Supriya Satti, Radhika Muppa, Ravichandra Sekhar Kotha, Srikanth Koya, Mrudhula J N Kantipudi, Ch Deepthi Siva Harika
CONTEXT: The most critical period for enamel fluorosis to develop is during the early years of life when enamel formation occurs. To minimize the risk of dental fluorosis development, monitoring fluoride intake during teeth development has been suggested. As infant formulae are major source of nutrition in infants, it is important to determine the fluoride content in them in order to monitor the fluoride intake in infants. AIMS: To estimate and comparatively evaluate the fluoride content in different commercially available infant formulae in India...
October 1, 2023: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://read.qxmd.com/read/38215664/inactivation-of-mst-nrf2-keap1-signaling-flexibly-mitigates-mapk-nqo-ho1-activation-in-the-reproductive-axis-of-experimental-fluorosis
#29
JOURNAL ARTICLE
Mohammad Mehdi Ommati, Samira Sabouri, Zilong Sun, Mohammad Javad Zamiri, Socorro Retana-Marquez, Hassan Nategh Ahmadi, Qiyong Zuo, Aziz Eftekhari, Lizbeth Juárez-Rojas, Yaser Asefi, Lina Lei, Shu-Gang Cui, Mohammad Hasan Jadidi, Hong-Wei Wang, Reza Heidari
Fluoride induced reprotoxicity through oxidative stress-mediated reproductive cell death. Hence, the current study evaluated the importance of the MST/Nrf2/MAPK/NQO-HO1 signaling pathway in fluorosis-induced reproductive toxicity. For this purpose, the reproductive toxicity of sodium fluoride (NaF) at physiological, biochemical, and intracellular levels was evaluated. In-vivo, NaF at 100 mg/L instigated physiological dysfunction, morphological, stereological, and structural injuries in the gut-gonadal axis of fluorosis mice through weakening the antioxidant signaling, Nrf2/HO-1/NQO1signaling pathway, causing the gut-gonadal barrier disintegrated via oxidative stress-induced inflammation, mitochondrial damage, apoptosis, and autophagy...
January 11, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38199481/riboflavin-alleviates-fluoride-induced-ferroptosis-by-il-17a-independent-system-xc-gpx4-pathway-and-iron-metabolism-in-testicular-leydig-cells
#30
JOURNAL ARTICLE
Xiang Li, Jie Yang, Erbao Shi, Yiguang Lu, Xiaochao Song, Huifeng Luo, Jundong Wang, Chen Liang, Jianhai Zhang
Fluoride is widely found in groundwater, soil, animal and plant organisms. Excessive fluoride exposure can cause reproductive dysfunction by activating IL-17A signaling pathway. However, the adverse effects of fluoride on male reproductive system and the mechanisms remain elusive. In this study, the wild type and IL-17A knockout C57BL/6J mouse were treated with 24 mg/kg·bw·d sodium fluoride and/or 5 mg/kg·bw·d riboflavin-5'-phosphate sodium for 91 days. Results showed that fluoride caused dental fluorosis, increased the levels of ROS in testicular Leydig cells and GSSG in testicular tissue, and did not affect the iron and serum hepcidin levels in testicular tissue...
January 8, 2024: Environmental Pollution
https://read.qxmd.com/read/38194606/poor-oral-health-and-the-risk-of-esophageal-squamous-cell-carcinoma-in-malawi
#31
JOURNAL ARTICLE
Bongani Kaimila, Yukiko Yano, Gift Mulima, Yingxi Chen, Chifundo Kajombo, Ande Salima, Shiraz Khan, Satish Gopal, Sanford M Dawsey, Christian C Abnet
Esophageal squamous cell carcinoma (ESCC) is the second most common cancer in Malawi. Risk factors for this cancer in Malawi are poorly understood. Poor oral health has previously been linked to increased ESCC risk in other high-incidence regions, including parts of Eastern and Southern Africa. We assessed the relationship between oral health and ESCC risk in a sex, age and location frequency-matched case-control study based at two hospitals in Lilongwe, Malawi from 2017 to 2020. Trained interviewers used a structured questionnaire and direct observation to collect data on demographics; behaviors; oral hygiene habits; the sum of decayed, missing or filled teeth (DMFT score); oral mucosa status; lip depigmentation and dental fluorosis via a visual scale...
January 9, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38186779/oral-health-status-treatment-needs-and-patterns-of-utilization-of-dental-services-among-village-volunteers-in-andhra-pradesh-a-cross-sectional-multi-stage-cluster-survey
#32
JOURNAL ARTICLE
Gadde Praveen, Manchikatla Sravani, Chaitanya Ram Kadiyala, Sai Lakshmi Durga Indukuri, Uls Poornima, Sravani Pampana
BACKGROUND: Community health depends on the leadership duties of a diverse population, such as village volunteers. Hence, a study was conducted to assess oral health status, treatment needs, and patterns of utilization of dental services among village volunteers in Andhra Pradesh state. METHODOLOGY: A cross-sectional study was conducted among 400 village volunteers in Andhra Pradesh state, India. A multi-stage cluster sampling procedure was employed in sample selection...
November 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38181596/calcium-supplementation-attenuates-fluoride-induced-bone-injury-via-pink1-parkin-mediated-mitophagy-and-mitochondrial-apoptosis-in-mice
#33
JOURNAL ARTICLE
Yingjun Hu, Yuanyuan Li, Meng Li, Tianrui Zhao, Wenhui Zhang, Yinghui Wang, Yang He, Hui Zhao, Haojie Li, Tianyu Wang, Yangfei Zhao, Jundong Wang, Jinming Wang
Excessive consumption of fluoride can cause skeletal fluorosis. Mitophagy has been identified as a novel target for bone disorders. Meanwhile, calcium supplementation has shown great potential for mitigating fluoride-related bone damage. Hence, this study aimed to elucidate the association between mitophagy and skeletal fluorosis and the precise mechanisms through which calcium alleviates these injuries. A 100 mg/L sodium fluoride (NaF) exposure model in Parkin knockout (Parkin-/- ) mice and a 100 mg/L NaF exposure mouse model with 1% calcium carbonate (CaCO3 ) intervention were established in the current study...
January 2, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38162876/fluoride-levels-in-almadinah-almunawwarah-bottled-water
#34
JOURNAL ARTICLE
May O Gamar Elanbya, AbdelRahman M Ramadan
OBJECTIVES: This research aimed to determine the fluoride levels in commercially available bottled waters and assess the accuracy of the fluoride levels labels on the bottles. METHODS: We obtained the labels from 28 water bottles from markets in Almadinah Almunawwarah. Water samples were diluted with an equal volume of total ionic strength adjustment buffer at the General Administration for Water Services. The electrode potential of each sample was then directly compared to standard fluoride solutions...
December 2023: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/38152906/a-bibliometric-study-of-trends-indicators-and-characteristics-in-the-global-scientific-production-on-fluorosis
#35
JOURNAL ARTICLE
Justiniano Sotomayor Camayo, Margot Gutierrez-Ilave, William Cardenas-Silva, Adrian Mallma-Medina, Katia Luz Medina Calderon, Fran Espinoza-Carhuancho, Frank Mayta-Tovalino
AIM: To perform an analysis of the trends, indicators, and characteristics of the world scientific production on fluorosis, and to evaluate its impact on scientific research in this field. MATERIALS AND METHODS: A descriptive, cross-sectional study was conducted with a bibliometric approach of the worldwide scientific production on fluorosis published during the years 2018-2023. All metadata were extracted from the Scopus database. The articles were exported in ...
October 1, 2023: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38149813/treatment-of-cases-with-different-grades-of-fluorosis-by-lithium-disilicate-glass-ceramic-cad-cam-materials-a-case-report-of-two-cases
#36
JOURNAL ARTICLE
Maram A Alahmari
Over exposure to high amount of fluoride during the development of enamel leads to fluorosis. Dental fluorosis is considered to be the most common color disorders of the enamel. It presents with different clinical signs on the enamel of the patients. The diagnosis of dental fluorosis is very challenging in the clinical practice since the enamel defects could be confusing. This case report presented two cases and their treatment for different grades of dental fluorosis to improve the esthetic appearance of the teeth...
May 1, 2023: Journal of Contemporary Dental Practice
https://read.qxmd.com/read/38145685/exposure-to-fluoride-exacerbates-the-cognitive-deficit-of-diabetic-patients-living-in-areas-with-endemic-fluorosis-as-well-as-of-rats-with-type-2-diabetes-induced-by-streptozotocin-via-a-mechanism-that-may-involve-excessive-activation-of-the-poly-adp-ribose
#37
JOURNAL ARTICLE
Jie Xiang, Xiao-Lan Qi, Kun Cao, Long-Yan Ran, Xiao-Xiao Zeng, Xiao Xiao, Wei Liao, Wen-Wen He, Wei Hong, Yan He, Zhi-Zhong Guan
Epidemiology has shown that fluoride exposure is associated with the occurrence of diabetes. However, whether fluoride affects diabetic encephalopathy is unclear. Elderly diabetic patients in areas with endemic (n = 169) or no fluorosis (108) and controls (85) underwent Montreal Cognitive Assessment. Sprague-Dawley rats receiving streptozotocin and/or different fluoride doses were examined for spatial learning and memory, brain morphology, blood-brain barrier, fasting blood glucose and insulin...
December 23, 2023: Science of the Total Environment
https://read.qxmd.com/read/38136098/worldwide-variations-in-fluoride-content-in-beverages-for-infants
#38
REVIEW
Eleonor Velez-León, Edisson-Mauricio Pacheco-Quito, Mario Díaz-Dosque, Daniela Tobar-Almache
In situations where breastfeeding is impractical, milk formulas have emerged as the primary choice for infant nutrition. Numerous global studies have scrutinized the fluoride content in these formulas, uncovering fluctuations in fluoride levels directly associated with the method of preparation. This variability poses a potential risk of elevated fluoride concentrations and, consequently, an increased susceptibility to dental fluorosis in infants. The primary objective of this review is to intricately delineate the fluoride content in dairy formulas and emphasize the variability of these values concerning their reconstitution process...
December 7, 2023: Children
https://read.qxmd.com/read/38135514/prevalence-of-skeletal-fluorosis-in-northern-tanzania-a-follow-up-study
#39
JOURNAL ARTICLE
Anna Foat, Claire Stevens, Grace George, John Massawe, Ally Mhina, William K Gray, Blandina T Mmbaga, Deogratias S Rwakatema, Paul Sallis, Helen Jarvis, Irene Haule, Daniel Benedict, Richard Walker
OBJECTIVES: Skeletal fluorosis is a metabolic bone disease caused by excessive exposure to fluoride, predominantly through contamination of drinking water. This study aimed to identify all cases of skeletal fluorosis in Tindigani village situated in Northern Tanzania. This was done following changes in drinking water sources after a previous prevalence study in 2009 in this population. METHODS: In a door-to-door cross-sectional study of Tindigani village, a sample of residents was assessed for skeletal fluorosis and dental fluorosis...
December 22, 2023: Global Health, Science and Practice
https://read.qxmd.com/read/38133094/fluorotic-enamel-susceptibility-to-dental-erosion-and-fluoride-treatment
#40
JOURNAL ARTICLE
Cristiane Araújo Maia Silva, Frederico Barbosa de Sousa, Esperanza Angeles Martinez-Mier, Basílio Rodrigues Vieira, Johnatan Meireles do Nascimento, Anderson Takeo Hara
The purpose of this in vitro study was to test the hypothesis that fluoride treatment can prevent dental erosion on fluorotic enamel of different severities. It followed a 3×2 factorial design, considering a) fluorosis severity: sound (TF0, Thylstrup-Fejerskov Index), mild (TF1-2), moderate (TF3-4); and b) fluoride treatment: 0 (negative control) and 1150ppmF. Human molars with the three fluorosis severities (n=16, each) were selected and randomly assigned to the two fluoride treatments (n=8). Enamel blocks (4×4mm) were prepared from each tooth and subjected to a dental erosion cycling model, for 10 days...
2023: Brazilian Dental Journal
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