Mohammad Mehdi Ommati, Samira Sabouri, Zilong Sun, Mohammad Javad Zamiri, Socorro Retana-Marquez, Hassan Nategh Ahmadi, Qiyong Zuo, Aziz Eftekhari, Lizbeth Juárez-Rojas, Yaser Asefi, Lina Lei, Shu-Gang Cui, Mohammad Hasan Jadidi, Hong-Wei Wang, Reza Heidari
Fluoride induced reprotoxicity through oxidative stress-mediated reproductive cell death. Hence, the current study evaluated the importance of the MST/Nrf2/MAPK/NQO-HO1 signaling pathway in fluorosis-induced reproductive toxicity. For this purpose, the reproductive toxicity of sodium fluoride (NaF) at physiological, biochemical, and intracellular levels was evaluated. In-vivo, NaF at 100 mg/L instigated physiological dysfunction, morphological, stereological, and structural injuries in the gut-gonadal axis of fluorosis mice through weakening the antioxidant signaling, Nrf2/HO-1/NQO1signaling pathway, causing the gut-gonadal barrier disintegrated via oxidative stress-induced inflammation, mitochondrial damage, apoptosis, and autophagy...
January 11, 2024: Ecotoxicology and Environmental Safety