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https://www.readbyqxmd.com/read/28079131/matrix-metallopeptidase-2-gene-rs2287074-polymorphism-is-associated-with-brick-tea-skeletal-fluorosis-in-tibetans-and-kazaks-china
#1
Junrui Pei, Bingyun Li, Yang Liu, Xiaona Liu, Mang Li, Yanru Chu, Qing Yang, Wei Jiang, Fuxun Chen, Gottfried M Darko, Yanmei Yang, Yanhui Gao
Brick tea skeletal fluorosis is still a public health issue in the north-western area of China. However its pathogenesis remains unknown. Our previous study reveals that the severity of skeletal fluorosis in Tibetans is more serious than that in Kazaks, although they have similar fluoride exposure, suggesting the onset of brick tea type skeletal fluorosis might be genetically influenced. Here we show that MMP-2 rs2287074 SNP (G/A), but not rs243865, was associated with Brick tea type fluorosis in Tibetans and Kazaks, China...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063715/probabilistic-risk-assessment-of-chinese-residents-exposure-to-fluoride-in-improved-drinking-water-in-endemic-fluorosis-areas
#2
Li E Zhang, Daizheng Huang, Jie Yang, Xiao Wei, Jian Qin, Songfeng Ou, Zhiyong Zhang, Yunfeng Zou
Studies have yet to evaluate the effects of water improvement on fluoride concentrations in drinking water and the corresponding health risks to Chinese residents in endemic fluorosis areas (EFAs) at a national level. This paper summarized available data in the published literature (2008-2016) on water fluoride from the EFAs in China before and after water quality was improved. Based on these obtained data, health risk assessment of Chinese residents' exposure to fluoride in improved drinking water was performed by means of a probabilistic approach...
January 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28032049/the-efficiency-of-child-formula-dentifrices-containing-different-calcium-and-phosphate-compounds-on-artificial-enamel-caries
#3
Praphasri Rirattanapong, Kadkao Vongsavan, Chavengkiat Saengsirinavin, Ploychompoo Khumsub
OBJECTIVES: Fluoride toothpaste has been extensively used to prevent dental caries. However, the risk of fluorosis is concerning, especially in young children. Calcium phosphate has been an effective remineralizing agent and is present in commercial dental products, with no risk of fluorosis to users. This in vitro study aimed to compare the effects of different calcium phosphate compounds and fluoride-containing dentifrices on artificial caries in primary teeth. MATERIALS AND METHODS: Fifty sound primary incisors were coated with nail varnish, leaving two 1 mm(2) windows on the labial surface before immersion in demineralizing solution for 96 hours to produce artificial enamel lesions...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28032042/dental-fluorosis-fluoride-in-urine-and-nutritional-status-in-adolescent-students-living-in-the-rural-areas-of-guanajuato-mexico
#4
Aguilar-Díaz Fatima Del Carmen, de la Fuente-Hernández Javier, Cintra-Viveiro Cristina Aline
OBJECTIVE: The aim of this study was to assess urine fluoride concentration, nutritional status, and dental fluorosis in adolescent students living in the rural areas of Guanajuato, Mexico. MATERIALS AND METHODS: A cross-sectional study was conducted including participants aged 11-20 years. The presence and severity of dental fluorosis was registered according to the Thylstrup and Fejerskov index (TFI) criteria. Anthropometric measures were also recorded. Urine sample of the first morning spot was recollected to assess urine fluoride concentration by using the potentiometric method with an ion-selective electrode...
November 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28025807/risk-factors-and-prevalence-of-dental-fluorosis-and-dental-caries-in-school-children-of-north-india
#5
Kavita Plaka, Khaiwal Ravindra, Suman Mor, Krishan Gauba
The aim of the study was to assess the prevalence of dental fluorosis, dental caries, and associated risk factors in the school children of district Fatehgarh Sahib, Punjab, India, using a cross-sectional study design. Oral health status of children aged between 8 and 15 years was assessed using World Health Organization (WHO) 2013 criteria. Dental fluorosis was assessed using Dean's index, and dental caries were recorded using decayed, missing, filled/decayed, extracted, filled (DMF/def) indices. Four hundred school children were examined, of which 207 were in the 8-11-year-old group and 193 were in the 12-15-year-old group...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27990615/sodium-fluoride-does-not-affect-the-working-memory-and-number-of-pyramidal-cells-in-rat-medial-prefrontal-cortex
#6
Zulhaini Sartika A Pulungan, Zaenal Muttaqien Sofro, Ginus Partadiredja
Fluoride is a chemical compound known to bring about fluorosis. It is thought to disrupt the central nervous system because of its ability to induce excitotoxicity and oxidative stress. Any damage of pyramidal cells in the prefrontal cortex would result in cognitive function and working memory regulation disorders. The present study aimed at investigating the effects of sodium fluoride (NaF) on the working memory and estimated total number of medial prefrontal cortex pyramidal cells of adult male rats. Thirty-two male Wistar rats were assigned into four groups, namely control and three treated groups receiving 5, 10 and 20 mg/kg BW, respectively, of oral NaF solution for 30 days...
December 18, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27917370/multiple-myeloma-like-spinal-mri-findings-in-skeletal-fluorosis-an-unusual-presentation-of-fluoride-toxicity-in-human
#7
Javed Ahsan Quadri, Mohd Meraj Alam, Saba Sarwar, Ashraf Ghanai, A Shariff, Taposh K Das
Endemic fluorosis is a worldwide environmental problem due to excessive fluoride, commonly due to increased drinking water fluoride levels but sometimes due to other sources such as food with high fluoride content. In India, 21 of the 35 states are known to have health problems associated with fluoride toxicity. The present report is a case of a 50-year-old female who was seen with progressive spinal complications and a MRI of the spine suggestive of multiple myeloma. The MRI of the lumbosacral spine showed a diffuse and heterogeneous marrow signal of the lower dorsal and lumbosacral vertebrae...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27871895/protective-effect-of-lycopene-on-fluoride-induced-ameloblasts-apoptosis-and-dental-fluorosis-through-oxidative-stress-mediated-caspase-pathways
#8
Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huang
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by orally administration for 5 weeks; ameloblasts were treated with NaF (5 mM) and/or LYC (2 μM) for 6 h. We found that the concentrations of fluoride, malondialdehyde (MDA) and reactive oxygen species (ROS), gene expressions and activities of Caspase-9 and Caspase-3, and the gene expressions of Bax were significantly decreased, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated rats group; concentrations of MDA and ROS, gene expressions and activities of Caspase-9 and Caspase-3, and the gene expression of Bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of SOD and GPX, the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated ameloblasts group...
January 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27847422/effect-of-tamarindus-indica-leaf-powder-on-plasma-concentrations-of-copper-zinc-and-iron-in-fluorotic-cows
#9
Pinaki Samal, R C Patra, A R Gupta, S K Mishra, D Jena, D Satapathy
AIM: The main objective of the study was to determine the deleterious effect of fluoride on plasma trace minerals of fluorotic cattle and to evaluate the effect of Tamarindus indica leaf powder toward correction of the same. MATERIALS AND METHODS: A total of 30 cattle exhibiting chronic sign of fluorosis and 10 healthy cattle from nonfluorotic area were incorporated in this study. Fluorotic cattle were divided into three equal groups consisting of 10 cattle each...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27843259/prevalence-of-dental-fluorosis-and-associated-risk-factors-in-bagalkot-district-karnataka-india
#10
Taranatha Mahantesha, Uma B Dixit, Ramesh P Nayakar, Devasya Ashwin, Naveen K Ramagoni, Vijaya P Kamavaram Ellore
INTRODUCTION: An earlier epidemiological study by these authors revealed fluorosis at very low levels of fluoride concentrations in drinking water. AIM: The objective of present study was to investigate risk factors of dental fluorosis in permanent teeth in the villages of northern Karnataka, India. MATERIALS AND METHODS: The present survey was carried out in three villages of Hungund Taluk, Bagalkot District, Karnataka, India, with the fluoride concentration of 0...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27836268/fluoride-enrichment-in-an-alluvial-aquifer-with-its-subsequent-effect-on-human-health-in-birbhum-district-west-bengal-india
#11
D Mondal, S Gupta, D V Reddy, G Dutta
This research work primarily deals with the geochemistry and genesis of fluoride (F(-)) in an alluvial aquifer with an emphasis on prevalence of dental and skeletal fluorosis among the endemic population. Hydrogeochemical outcomes reveal that chemical weathering and ion-exchange phenomena are the two dominant processes that make study area groundwater into NaHCO3 water type. Presence of intercalated zeolite rich sediments (FTotal 412-446 mg/kg) having higher ion-exchange capacity (120-125 meq/100 g) within the aquifer is the source and mobilizing factors of F(-) in groundwater respectively...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27834326/validation-of-icmr-index-for-identification-of-dental-fluorosis-in-epidemiological-studies
#12
Ashima Goyal, Mahesh Verma, G S Toteja, K Gauba, Vikrant Mohanty, Utkal Mohanty, Rupinder Kaur
BACKGROUND & OBJECTIVES: The Indian Council of Medical Research (ICMR) formulated a Task Force on dental fluorosis and recommended the subgroup to develop a simplified index for identification and grading of dental fluorosis to be used by the health workers. This study was conducted to pre-test the 'ICMR Index for Dental Fluorosis' in the field to check its reliability and reproducibility. METHODS: A total of 600 photographs were taken, 150 in each grade of fluorosis by screening 14-17 yr school children from eight schools of Hisar (Haryana) and South west Delhi...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27814262/interdisciplinary-approach-to-complete-mouth-rehabilitation-a-clinical-report
#13
Rahul S Kulkarni, Sandeep K Pimpale, Suryakant N Powar
Dental fluorosis results from excess fluoride ingestion during tooth formation and is commonly seen in certain endemic areas. Its clinical manifestations may range from white opaque patches of enamel in mild cases to pitting and loss of enamel in severe cases. The treatment of fluorosis is important not only because of esthetic and functional concerns but also to help improve a patient's self-esteem; therefore, a multidisciplinary approach is often necessary. This article describes a multidisciplinary approach to complete-mouth rehabilitation of a patient affected with fluorosis...
November 2016: General Dentistry
https://www.readbyqxmd.com/read/27787813/the-influence-of-fluorine-on-the-disturbances-of-homeostasis-in-the-central-nervous-system
#14
REVIEW
K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowska
Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine...
October 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27765257/composition-distribution-and-risk-of-total-fluorine-extractable-organofluorine-and-perfluorinated-compounds-in-chinese-teas
#15
Ruobing Zhang, Hong Zhang, Qingwu Chen, Ji Luo, Zhifang Chai, Jincan Shen
To explore the residual characteristics of fluorine and perfluorinated compounds (PFCs) in tea, the total fluorine (TF), extractable organofluorine (EOF) and PFCs in 19 Chinese commercial teas of five categories were measured using cyclic neutron activation analysis combined with HPLC-MS/MS. The results showed that fluorine mainly existed as inorganic fluorine in teas, and identified fluorine (∑PFCs quantified as F) only accounted for 0.023-0.41% of EOF, indicating that most EOF in tea were still unknown...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27744011/magnesium-ph-regulation-and-modulation-by-mouse-ameloblasts-exposed-to-fluoride
#16
Antonius Ljj Bronckers, Donacian M Lyaruu
Supraoptimal intake of fluoride (F) induces structural defects in forming enamel, dentin and bone and increases the risk of bone fractures. In comparison to bone and dentin is formation of enamel most sensitive to low levels of F and the degree of enamel fluorosis depends on the mouse strain. What molecular mechanism is responsible for these differences in sensitivity is unclear. Maturation ameloblasts transport bicarbonates into enamel in exchange for Cl- to buffer protons released by forming apatites. We proposed that F-enhanced mineral deposition releases excess of protons that will affect mineralization in forming enamel...
January 2017: Bone
https://www.readbyqxmd.com/read/27702735/endemic-fluorosis-in-henan-province-china-er%C3%AE-gene-polymorphisms-and-reproductive-hormones-among-women
#17
Guo-Yu Zhou, Li-Jun Ren, Jia-Xiang Hou, Liu-Xin Cui, Zhong Ding, Xue-Min Cheng, Jing-Yuan Zhu, Rui-Rui Cui, Yue Ba
BACKGROUND AND OBJECTIVES: The aim of this study was to explore the influence of fluoride exposure and ERα gene polymorphisms on reproductive hormone concentrations of women in accordance with endemic fluorosis residence. METHODS AND STUDY DESIGN: A cross sectional study was conducted in Tongxu county, Henan Province, China. A total of 679 women were recruited using cluster sampling and each subject provided fasting blood and an associated urine sample. We measured the concentrations of serum gonadotropin releasing hormone (GnRH), follicle-stimulating hormone, luteinizing hormone, and estradiol and urinary fluoride...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27690006/itraq-based-proteomics-analysis-of-serum-proteins-in-wistar-rats-treated-with-sodium-fluoride-insight-into-the-potential-mechanism-and-candidate-biomarkers-of-fluorosis
#18
Yan Wei, Beibei Zeng, Hua Zhang, Cheng Chen, Yanli Wu, Nanlan Wang, Yanqiu Wu, Liming Shen
Fluorosis induced by exposure to high level fluoride is quite widespread in the world. The manifestations of fluorosis include dental mottling, bone damage, and impaired malfunction of soft tissues. However, the molecular mechanism of fluorosis has not been clarified until now. To explore the underlying mechanisms of fluorosis and screen out serum biomarkers, we carried out a quantitative proteomics study to identify differentially expressed serum proteins in Wistar rats treated with sodium fluoride (NaF) by using a proteomics approach of isobaric tagging for relative and absolute quantitation (iTRAQ)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27678306/dental-caries-fluorosis-oral-health-determinants-and-quality-of-life-in-adolescents
#19
N R Aimée, A J van Wijk, M Maltz, M M Varjão, H D Mestrinho, J C Carvalho
OBJECTIVE: This study aimed to assess the extent to which dental caries and fluorosis, in addition to sociodemographic and oral health behavior determinants, impact the oral health-related quality of life (OHRQoL) of adolescents. METHODS: All adolescents attending from sixth to eighth grades in the Region of Itapoã, Federal District of Brazil (n = 1122), were screened, and 618 10-15-year-olds were selected. Parents answered a questionnaire about their family's socioeconomic status...
September 27, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27671177/caries-with-dental-fluorosis-and-oral-health-behaviour-among-12-year-school-children-in-moderate-fluoride-drinking-water-community-in-quetta-pakistan
#20
Erum Sami, Tippanart Vichayanrat, Pratana Satitvipawee
OBJECTIVE: To determine the prevalence of dental caries and its relationship with dental fluorosis, oral health behaviour and dietary behaviour among 12-year school children in moderate-fluoride drinking water community in Quetta, Pakistan. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Government and private schools of Quetta, from November 2012 to February 2013. METHODOLOGY: Atotal of 349 children aged 12-year from 14 randomly selected schools were included...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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