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Adimalla Narsimha
Fluoride beyond desirable amounts(0.6-1.5 mg/L) in groundwater is a major problem and fluorosis is a very dangerous and deadly disease affecting millions of people across the World (Bell and Ludwig, 1970; Adimalla and Venkatayogi, 2017; Narsimha and Sudarshan, 2013, 2017a, 2017b) [1], [2], [3], [4], [5]. The investigated area is located in north-eastern part of Medak district, Telangana state and fluoride concentration in groundwater samples was measured by ion selective electrode method and its ranges from 0...
February 2018: Data in Brief
Jaishabanu Ameeramja, Ekambaram Perumal
Fluorosis (fluoride toxicity) seems to be reduced by plant secondary metabolites. Tamarind seed coat extract (TSCE), a mixture of procyanidins and polyphenols, possesses numerous pharmacological activities. Regardless of its beneficial properties, the underlying molecular mechanism against chronic fluorosis in vivo is not known. Hence, the present study is aimed to investigate the efficacy of TSCE against fluoride (F- )-induced pulmonary toxicity in rats. Female Wistar rats were randomly divided into four groups and treated with NaF (300 ppm in drinking water) and TSCE (100 mg/kg/bw by oral intubation) alone and in combination daily for 30 days...
March 5, 2018: Inflammation
Yangfei Zhao, Yanyan Li, Yufeng Gao, Mengke Yuan, Ram Kumar Manthari, Jinming Wang, Jundong Wang
It is well known that excess fluoride intake can result in fluorosis, which is a serious public health problem. TGF-β1 affects a wide variety of cellular activities and plays an important role in fluorosis. Recent literature proved that fluoride induces autophagy, however, the mechanism is still unclear, and the role of TGF-β1 in the fluoride-induced autophagy should be further illustrated. Therefore, in this study, plasmids and small interfering RNA (siRNA) were used to overexpress and silence the TGF-β1 expression in the osteoblasts cells...
March 2, 2018: Food and Chemical Toxicology
Danni Li, Xubo Gao, Yanxin Wang, Wenting Luo
Excessive amounts of fluoride in drinking groundwater are harmful to human health, but the mechanisms responsible for fluoride enrichment in groundwater are not fully understood. Samples from two neighboring areas with endemic fluorosis were collected to test the hypothesis that there are distinctly different mechanisms responsible for the enrichment of fluoride in these groundwater. Hydrochemistry, stable isotopes and geochemical simulation were conducted together to investigate the fluoride spatial distribution and the diversity of responsible mechanisms...
March 1, 2018: Environmental Pollution
R Constance Wiener, Chan Shen, Patricia Findley, Xi Tan, Usha Sambamoorthi
Purpose: Excessive fluoride ingestion has been associated with dental fluorosis. The purpose of this study was to determine if there was a difference in dental fluorosis prevalence comparing National Health and Nutrition Examination Survey (NHANES) trend data for adolescents, aged 16 and 17 years, when compared to data collected in 2001-2002 to data from 2011-2012. Methods: The sample included 875 participants. Data analyses included Chi square tests and logistic regressions. The data were from a nationally representative survey by calibrated dental examiners using the modified Dean's fluorosis classification system...
February 2018: Journal of Dental Hygiene: JDH
F V Zohoori, A Maguire
This opinion piece highlights the importance of controlling systemic fluoride intake from food and drink in early childhood to minimise risk of dental fluorosis whilst maximising caries prevention; the wide range of fluoride contents found in a study of commercially-available food and drinks; and the need for comprehensive fluoride labelling on food and drink products in the UK, particularly those used by infants and young children.
February 23, 2018: British Dental Journal
Yuting Jiang, Yanmei Yang, Hongge Wang, Gottfried M Darko, Dianjun Sun, Yanhui Gao
The skeletal lesion of fluoride has become a major concern in many countries due to its damage to bone and joints and even leading to disability. Skeletal fluorosis is characterized by disturbance of bone metabolism, aberrant proliferation and activation of osteoblasts is critical for the pathogenesis. However, the mechanism underlying the osteotoxicity of fluoride has not been clearly illustrated and there is still limited information on the role of miRNAs in skeletal fluorosis. In this study, we found that NaF promoted SaoS2 proliferation and activation by activating BMP4/Smad pathway...
February 19, 2018: Chemosphere
Yinze Diao, Yu Sun, Shaobo Wang, Fengshan Zhang, Shengfa Pan, Zhongjun Liu
RATIONALE: The typical intraoperative presentation of vertebral artery injury (VAI) usually involves profuse bleeding and requires immediate treatment. However, an occult VAI may occur intraoperatively and result in delayed life-threatening epidural pseudoaneurysm several days postoperatively. PATIENT CONCERNS: A 21-year-old man with compressive cervical myelopathy resulting from canal stenosis of skeletal fluorosis underwent decompression of C1 to C7 and instrumentation from C2 to C7...
February 2018: Medicine (Baltimore)
A J Spencer, L G Do, U Mueller, J Baines, M Foley, M A Peres
Policy on fluoride intake involves balancing caries against dental fluorosis in populations. The origin of this balance lies with Dean's research on fluoride concentration in water supplies, caries, and fluorosis. Dean identified cut points in the Index of Dental Fluorosis of 0.4 and 0.6 as critical. These equate to 1.3 and 1.6 mg fluoride (F)/L. However, 1.0 mg F/L, initially called a permissible level, was adopted for fluoridation programs. McClure, in 1943, derived an "optimum" fluoride intake based on this permissible concentration...
March 2018: Advances in Dental Research
I Mejàre
The purpose of this report is to examine critically the appropriateness of the current guidance for fluoride intake in the population (0.05-0.07 mg F/kg bodyweight/d), consider whether changes to the current guidance are desirable, and suggest further research that will strengthen the evidence base for future decisions on guidance/advice in this area. The benefits and the risks of using fluoride particularly concern preschool children because it is at this age that excessive fluoride intake may result in dental fluorosis...
March 2018: Advances in Dental Research
M A R Buzalaf
Since the classical epidemiological studies by Dean, it has been known that there should be an optimum level of exposure to fluoride that would be able to provide the maximum protection against caries, with minimum dental fluorosis. The "optimal" daily intake of fluoride for children (0.05-0.07 mg per kilogram bodyweight) that is still accepted worldwide was empirically determined. In the present review, we discuss the appropriateness of the current guidance for fluoride intake, in light of the windows of susceptibility to caries and fluorosis, the modern trends of fluoride intake from multiple sources, individual variations in fluoride metabolism, and recent epidemiological data...
March 2018: Advances in Dental Research
Arjun L Khandare, Vakdevi Validandi, Naveen Boiroju
The present study aimed to determine the serum trace elements (copper (Cu), zinc (Zn), calcium (Ca), magnesium (Mg)) along with erythrocyte carbonic anhydrase (CA) activity and effect of intervention with safe drinking water for 5 years in the school children of fluorosis endemic area. For this purpose, three categories of villages were selected based on drinking water fluoride (F): Category I (control, F = 1.68 mg/L), category II (affected F = 3.77 mg/L), and category III (intervention village) where initial drinking water F was 4...
February 17, 2018: Biological Trace Element Research
Sandra L Amaral, Liane B Azevedo, Marilia A R Buzalaf, Mayara F Fabricio, Mileni S Fernandes, Ruth A Valentine, Anne Maguire, Fatemeh V Zohoori
The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment...
February 16, 2018: Scientific Reports
J A Quadri, S Sarwar, A Sinha, M Kalaivani, A K Dinda, A Bagga, T S Roy, T K Das, A Shariff
The susceptibility of the kidneys to fluoride toxicity can largely be attributed to its anatomy and function. As the filtrate moves along the complex tubular structure of each nephron, it is concentrated in the proximal and distal tubules and collecting duct. It has been frequently observed that the children suffering from renal impairments also have some symptoms of dental and skeletal fluorosis. The findings suggest that fluoride somehow interferes with renal anatomy and physiology, which may lead to renal pathogenesis...
January 1, 2018: Human & Experimental Toxicology
Saba Aghapour, Bijan Bina, Mohammad Javad Tarrahi, Fahimeh Amiri, Afshin Ebrahimi
Fluoride (F) contamination in groundwater can be problematic to human health. This study evaluated the concentration of fluoride in groundwater resources of Isfahan Province, the central plateau of Iran, and its related health issues to the inhabitant populations. For this purpose, 573 drinking groundwater samples were analyzed in 2016 by using the spectrophotometric method. Non-carcinogenic health risks due to F exposure through consumption of drinking water were assessed using the US EPA method. In addition, the associated zoning maps of the obtained results were presented using geographic information system (GIS)...
February 13, 2018: Environmental Monitoring and Assessment
Shuan-Chi Wang, Xiao-Bing Tao, Fang-Fang Wang, Nan Zhang
OBJECTIVE: To investigate the mechanism of diabetes insipidus complicated with skeletal fluorosis and the surgical treatment of spinal canal stenosis caused by skeletal fluorosis. METHODS: From January 2000 to November 2011, 5 patients with diabetes insipidus complicated with skeletal fluorosis were treated with drug and cervical or thoracic posterior decompression including 2 males and 3 females with age of 35, 45, 47, 49, 55 years old respectively. The symptoms was mainly limb motor sensory disturbance accompanied by polyuria and polyuria...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Neeti Rustagi, Ajey Singh Rathore, Jitendra Kumar Meena, Ankita Chugh, Ranabir Pal
Background: Ingestion of excess fluoride can cause fluorosis which adversely affects teeth and bones. Fluorosis is a major public health problem in the state of Rajasthan with all its 32 districts having variable fluoride contamination, and many initiatives are currently implemented in this region to mitigate the fluorosis burden. Objective: The objective of this study was to assess fluorosis, its risk factors, and the awareness among school students and teachers in endemic villages of Jodhpur district, Rajasthan...
July 2017: Journal of Family Medicine and Primary Care
Julien Paccou, Laetitia Michou, Sami Kolta, Françoise Debiais, Bernrard Cortet, Pascal Guggenbuhl
A finding of high bone mineral density (BMD) from routine dual-energy X-ray absorptiometry (DXA) screening is not uncommon. No consensus exists about the definition of high BMD, and T-score and/or Z-score cutoffs of ≥+2.5 or ≥+4 have been suggested. The many disorders that can result in high BMD are usually classified based on whether the BMD changes are focal vs. generalized or acquired vs. constitutional. In over half the cases, careful interpretation of the DXA report and images identifies the cause as an artefact (e...
January 30, 2018: Joint, Bone, Spine: Revue du Rhumatisme
Brenda Lorena Fina, Maela Lupo, Eugenia Rocío Da Ros, Mercedes Lombarte, Alfredo Rigalli
Bone deformation and fragility are common signs of skeletal fluorosis. Disorganisation of bone tissue and presence of inflammatory foci were observed after fluoride (F-) administration. Most information about F- effects on bone has been obtained in adult individuals. However, in fluorosis areas, children are a population very exposed to F- and prone to develop not only dental but also skeletal fluoroses. The aim of this work was to evaluate the bone parameters responsible for the effect of different doses of F- on fracture load of the trabecular and cortical bones using multivariate analysis in growing rats...
February 2, 2018: Biological Trace Element Research
Arjun L Khandare, Vakdevi Validandi, Shankar Rao Gourineni, Viswanathan Gopalan, Balakrishna Nagalla
Fluorosis is a public health problem in India; to know its prevalence and severity along with its mitigation measures is very important. The present study has been undertaken with the aim to assess the F dose-dependent clinical and subclinical symptoms of fluorosis and reversal of the disease by providing safe drinking water. For this purpose, a cross-sectional study was undertaken in 1934 schoolgoing children, Nalgonda district. Study villages were categorized into control (category I, F = 0.87 mg/L), affected (category II, F = 2...
February 2, 2018: Environmental Monitoring and Assessment
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