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https://www.readbyqxmd.com/read/27871895/protective-effect-of-lycopene-on-fluoride-induced-ameloblasts-apoptosis-and-dental-fluorosis-through-oxidative-stress-mediated-caspase-pathways
#1
Weishan Li, Binghua Jiang, Xianglin Cao, Yongjiang Xie, Ting Huang
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by orally administration for 5 weeks; ameloblasts were treated with NaF (5 mM) and/or LYC (2 μM) for 6 h. We found that the concentrations of fluoride, malondialdehyde (MDA) and reactive oxygen species (ROS), gene expressions and activities of Caspase-9 and Caspase-3, and the gene expressions of Bax were significantly decreased, while the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX), the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated rats group; concentrations of MDA and ROS, gene expressions and activities of Caspase-9 and Caspase-3, and the gene expression of Bax, and ameloblasts apoptosis rate were significantly decreased, while the activities of SOD and GPX, the gene expression of Bcl-2 were significantly increased in the LYC + NaF-treated ameloblasts group...
November 18, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27847422/effect-of-tamarindus-indica-leaf-powder-on-plasma-concentrations-of-copper-zinc-and-iron-in-fluorotic-cows
#2
Pinaki Samal, R C Patra, A R Gupta, S K Mishra, D Jena, D Satapathy
AIM: The main objective of the study was to determine the deleterious effect of fluoride on plasma trace minerals of fluorotic cattle and to evaluate the effect of Tamarindus indica leaf powder toward correction of the same. MATERIALS AND METHODS: A total of 30 cattle exhibiting chronic sign of fluorosis and 10 healthy cattle from nonfluorotic area were incorporated in this study. Fluorotic cattle were divided into three equal groups consisting of 10 cattle each...
October 2016: Veterinary World
https://www.readbyqxmd.com/read/27843259/prevalence-of-dental-fluorosis-and-associated-risk-factors-in-bagalkot-district-karnataka-india
#3
Taranatha Mahantesha, Uma B Dixit, Ramesh P Nayakar, Devasya Ashwin, Naveen K Ramagoni, Vijaya P Kamavaram Ellore
INTRODUCTION: An earlier epidemiological study by these authors revealed fluorosis at very low levels of fluoride concentrations in drinking water. AIM: The objective of present study was to investigate risk factors of dental fluorosis in permanent teeth in the villages of northern Karnataka, India. MATERIALS AND METHODS: The present survey was carried out in three villages of Hungund Taluk, Bagalkot District, Karnataka, India, with the fluoride concentration of 0...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27836268/fluoride-enrichment-in-an-alluvial-aquifer-with-its-subsequent-effect-on-human-health-in-birbhum-district-west-bengal-india
#4
D Mondal, S Gupta, D V Reddy, G Dutta
This research work primarily deals with the geochemistry and genesis of fluoride (F(-)) in an alluvial aquifer with an emphasis on prevalence of dental and skeletal fluorosis among the endemic population. Hydrogeochemical outcomes reveal that chemical weathering and ion-exchange phenomena are the two dominant processes that make study area groundwater into NaHCO3 water type. Presence of intercalated zeolite rich sediments (FTotal 412-446 mg/kg) having higher ion-exchange capacity (120-125 meq/100 g) within the aquifer is the source and mobilizing factors of F(-) in groundwater respectively...
November 8, 2016: Chemosphere
https://www.readbyqxmd.com/read/27834326/validation-of-icmr-index-for-identification-of-dental-fluorosis-in-epidemiological-studies
#5
Ashima Goyal, Mahesh Verma, G S Toteja, K Gauba, Vikrant Mohanty, Utkal Mohanty, Rupinder Kaur
BACKGROUND & OBJECTIVES: The Indian Council of Medical Research (ICMR) formulated a Task Force on dental fluorosis and recommended the subgroup to develop a simplified index for identification and grading of dental fluorosis to be used by the health workers. This study was conducted to pre-test the 'ICMR Index for Dental Fluorosis' in the field to check its reliability and reproducibility. METHODS: A total of 600 photographs were taken, 150 in each grade of fluorosis by screening 14-17 yr school children from eight schools of Hisar (Haryana) and South west Delhi...
July 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27814262/interdisciplinary-approach-to-complete-mouth-rehabilitation-a-clinical-report
#6
Rahul S Kulkarni, Sandeep K Pimpale, Suryakant N Powar
Dental fluorosis results from excess fluoride ingestion during tooth formation and is commonly seen in certain endemic areas. Its clinical manifestations may range from white opaque patches of enamel in mild cases to pitting and loss of enamel in severe cases. The treatment of fluorosis is important not only because of esthetic and functional concerns but also to help improve a patient's self-esteem; therefore, a multidisciplinary approach is often necessary. This article describes a multidisciplinary approach to complete-mouth rehabilitation of a patient affected with fluorosis...
November 2016: General Dentistry
https://www.readbyqxmd.com/read/27787813/the-influence-of-fluorine-on-the-disturbances-of-homeostasis-in-the-central-nervous-system
#7
REVIEW
K Dec, A Łukomska, D Maciejewska, K Jakubczyk, I Baranowska-Bosiacka, D Chlubek, A Wąsik, I Gutowska
Fluorides occur naturally in the environment, the daily exposure of human organism to fluorine mainly depends on the intake of this element with drinking water and it is connected with the geographical region. In some countries, we can observe the endemic fluorosis-the damage of hard and soft tissues caused by the excessive intake of fluorine. Recent studies showed that fluorine is toxic to the central nervous system (CNS). There are several known mechanisms which lead to structural brain damage caused by the excessive intake of fluorine...
October 27, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27765257/composition-distribution-and-risk-of-total-fluorine-extractable-organofluorine-and-perfluorinated-compounds-in-chinese-teas
#8
Ruobing Zhang, Hong Zhang, Qingwu Chen, Ji Luo, Zhifang Chai, Jincan Shen
To explore the residual characteristics of fluorine and perfluorinated compounds (PFCs) in tea, the total fluorine (TF), extractable organofluorine (EOF) and PFCs in 19 Chinese commercial teas of five categories were measured using cyclic neutron activation analysis combined with HPLC-MS/MS. The results showed that fluorine mainly existed as inorganic fluorine in teas, and identified fluorine (∑PFCs quantified as F) only accounted for 0.023-0.41% of EOF, indicating that most EOF in tea were still unknown...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27744011/magnesium-ph-regulation-and-modulation-by-mouse-ameloblasts-exposed-to-fluoride
#9
Antonius Ljj Bronckers, Donacian M Lyaruu
Supraoptimal intake of fluoride (F) induces structural defects in forming enamel, dentin and bone and increases the risk of bone fractures. In comparison to bone and dentin is formation of enamel most sensitive to low levels of F and the degree of enamel fluorosis depends on the mouse strain. What molecular mechanism is responsible for these differences in sensitivity is unclear. Maturation ameloblasts transport bicarbonates into enamel in exchange for Cl- to buffer protons released by forming apatites. We proposed that F-enhanced mineral deposition releases excess of protons that will affect mineralization in forming enamel...
January 2017: Bone
https://www.readbyqxmd.com/read/27702735/endemic-fluorosis-in-henan-province-china-er%C3%AE-gene-polymorphisms-and-reproductive-hormones-among-women
#10
Guo-Yu Zhou, Li-Jun Ren, Jia-Xiang Hou, Liu-Xin Cui, Zhong Ding, Xue-Min Cheng, Jing-Yuan Zhu, Rui-Rui Cui, Yue Ba
BACKGROUND AND OBJECTIVES: The aim of this study was to explore the influence of fluoride exposure and ERα gene polymorphisms on reproductive hormone concentrations of women in accordance with endemic fluorosis residence. METHODS AND STUDY DESIGN: A cross sectional study was conducted in Tongxu county, Henan Province, China. A total of 679 women were recruited using cluster sampling and each subject provided fasting blood and an associated urine sample. We measured the concentrations of serum gonadotropin releasing hormone (GnRH), follicle-stimulating hormone, luteinizing hormone, and estradiol and urinary fluoride...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27690006/itraq-based-proteomics-analysis-of-serum-proteins-in-wistar-rats-treated-with-sodium-fluoride-insight-into-the-potential-mechanism-and-candidate-biomarkers-of-fluorosis
#11
Yan Wei, Beibei Zeng, Hua Zhang, Cheng Chen, Yanli Wu, Nanlan Wang, Yanqiu Wu, Liming Shen
Fluorosis induced by exposure to high level fluoride is quite widespread in the world. The manifestations of fluorosis include dental mottling, bone damage, and impaired malfunction of soft tissues. However, the molecular mechanism of fluorosis has not been clarified until now. To explore the underlying mechanisms of fluorosis and screen out serum biomarkers, we carried out a quantitative proteomics study to identify differentially expressed serum proteins in Wistar rats treated with sodium fluoride (NaF) by using a proteomics approach of isobaric tagging for relative and absolute quantitation (iTRAQ)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27678306/dental-caries-fluorosis-oral-health-determinants-and-quality-of-life-in-adolescents
#12
N R Aimée, A J van Wijk, M Maltz, M M Varjão, H D Mestrinho, J C Carvalho
OBJECTIVE: This study aimed to assess the extent to which dental caries and fluorosis, in addition to sociodemographic and oral health behavior determinants, impact the oral health-related quality of life (OHRQoL) of adolescents. METHODS: All adolescents attending from sixth to eighth grades in the Region of Itapoã, Federal District of Brazil (n = 1122), were screened, and 618 10-15-year-olds were selected. Parents answered a questionnaire about their family's socioeconomic status...
September 27, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27671177/caries-with-dental-fluorosis-and-oral-health-behaviour-among-12-year-school-children-in-moderate-fluoride-drinking-water-community-in-quetta-pakistan
#13
Erum Sami, Tippanart Vichayanrat, Pratana Satitvipawee
OBJECTIVE: To determine the prevalence of dental caries and its relationship with dental fluorosis, oral health behaviour and dietary behaviour among 12-year school children in moderate-fluoride drinking water community in Quetta, Pakistan. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Government and private schools of Quetta, from November 2012 to February 2013. METHODOLOGY: Atotal of 349 children aged 12-year from 14 randomly selected schools were included...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27651877/the-prevalence-of-dental-fluorosis-and-exposure-to-fluoride-in-drinking-water-a-systematic-review
#14
Fatemeh Goodarzi, Amir Hossein Mahvi, Mostafa Hosseini, Saharnaz Nedjat, Ramin Nabizadeh Nodehi, Mohammad Javad Kharazifard, Mina Parvizishad, Zahra Cheraghi
Background. Regarding the lack of comprehensive systematic review on the efficacy of water fluoridation and prevalence of dental fluorosis, the aim of the current research was to systematically study the prevalence of dental fluorosis at different levels of water fluoride in the world and lay emphasis on the amount of fluoride in drinking water. Methods. Studies were searched in PubMed, Scopus, SID, and IranMedex, with regard to inclusion criteria. Study validity was assessed with some checklists, and analyses were performed to ascertain the prevalence of dental fluorosis among individuals categorized in age groups...
2016: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/27649844/total-daily-fluoride-intake-and-fractional-urinary-fluoride-excretion-in-4-to-6-year-old-children-living-in-a-fluoridated-area-weekly-variation
#15
Narges Omid, Anne Maguire, William T O'Hare, Fatemeh V Zohoori
OBJECTIVES: Risk of development of dental fluorosis may increase with even a short-term increase in fluoride (F) intake during tooth formation. Considering the wide variations in F concentrations of different food and drinks, it is important to assess short-term differences in F intake and consequently fractional urinary F excretion (FUFE) in children, which provide an indication of F body burden. Therefore, the aim of this study was to investigate weekly variation in total daily F intake (TDFI) and its sources and fractional urinary F excretion (FUFE) in 4- to 6-year-olds living in a fluoridated area in the UK...
September 21, 2016: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/27644876/fluorosis-increases-the-risk-of-postmenopausal-osteoporosis-by-stimulating-interferon-%C3%AE
#16
Yun-Gang Lv, Li Kang, Guangyao Wu
Estrogen deficiency in postmenopausal women frequently activates osteoclasts (OC), accelerates bone resorption, and leads to osteoporosis (OP). Previous studies have demonstrated that interferon γ (IFNγ) could increase bone resorption and may be involved in postmenopausal OP. Fluorosis also increased the risk of fractures and dental fluorosis, and fluoride may enhance osteoclast formation and induce osteoclastic bone destruction in postmenopausal women, but the underlying mechanisms are as yet unknown. Here, we show that serum fluoride and IFNγ levels are negatively correlated with bone mineral density (BMD) in postmenopausal women residing in a fluorotic area...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27624793/ls8-cell-apoptosis-induced-by-naf-through-p-erk-and-p-jnk-a-mechanism-study-of-dental-fluorosis
#17
Lin Zhao, Juedan Li, Jiali Su, Malcolm L Snead, Jianping Ruan
OBJECTIVE: To investigate the possible biological mechanism of dental fluorosis at a molecular level. MATERIAL AND METHODS: Cultured LS8 were incubated with serum-free medium containing selected concentrations of NaF (0 ∼ 2 mM) for either 24 or 48 h. Subcellular microanatomy was characterized using TEM; meanwhile, selected biomolecules were analysed using various biochemistry techniques. Transient transfection was used to modulate a molecular pathway for apoptosis...
October 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27598787/oral-health-in-the-agenda-of-priorities-in-public-health
#18
José Leopoldo Ferreira Antunes, Tatiana Natasha Toporcov, João Luiz Bastos, Paulo Frazão, Paulo Capel Narvai, Marco Aurélio Peres
This study describes the scientific production on oral health diffused in Revista de Saúde Pública, in the 50 years of its publication. A narrative review study was carried out using PubMed, as it is the search database that indexes all issues of the journal. From 1967 to 2015, 162 manuscripts specifically focused on oral health themes were published. This theme was present in all volumes of the journal, with increasing participation over the years. Dental caries was the most studied theme, constantly present in the journal since its first issue...
September 1, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/27596345/-effect-of-magnesium-and-selenium-on-the-expression-of-matrix-metalloproteinases-20-and-kallikrein-4-in-fluorosis-mice
#19
F Wang, T Z Hou, J J Li, Z Z Li, C F Tang
OBJECTIVE: To study the effect of magnesium/selenium on the expression of matrix metalloproteinases-20(MMP-20) and kallikrein 4(KLK4) during fluorosis in mice and to explore the formation mechanism of dental fluorosis. METHODS: Eighty SPF male ICR mice were randomly divided into 8 groups according to body weight: control group, magnesium group, selenium group, magnesium-selenium group, fluoride group, magnesium-fluorine group, selenium-fluorine group and magnesium-selenium-fluorine group...
September 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27591763/groundwater-fluoride-contamination-and-its-possible-health-implications-in-indi-taluk-of-vijayapura-district-karnataka-state-india
#20
Vidyavati Ugran, Naveen N Desai, Dipankar Chakraborti, Kallappa A Masali, Prakash Mantur, Shreepad Kulkarni, Niranjan Deshmukh, Kailash S Chadchan, Swastika N Das, Anuradha S Tanksali, Asha S Arwikar, Suresh P Guggarigoudar, Tejaswini Vallabha, Shailaja S Patil, Kusal K Das
Groundwater fluoride concentration and fluoride-related health problems were studied in twenty-two villages of Indi taluk of Vijayapura district, Karnataka, India. Present study (2015) was also used to compare groundwater fluoride concentration in same 22 villages with previous government report (2000). Groundwater fluoride concentrations of 62 bore wells of 22 villages were analyzed by using an ion-sensitive electrode. A total of 660 adults and 600 children were screened for fluorosis symptoms and signs. Sixty clinically suspected fluorosis patients' urine samples were further analyzed for fluoride...
September 3, 2016: Environmental Geochemistry and Health
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