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K Görkem Ulu Güzel, Münciye Semra Özay Ertürk, Zuhal Kırzıoğlu, Suat Özkorucuklu
OBJECTIVE: The in vitro permeability characteristics of dentin have been studied extensively and used to evaluate the efficacy of various preventative and restorative procedures. The aim of this in vitro study was to precisely determine the dentin permeability of fluorotic premolar teeth using an electronic hydraulic conductance measurement system with photosensors and to compare the data with healthy premolars. METHODS: In total, 40 fluorotic and healthy premolar teeth with complete root formation that were extracted for orthodontic purposes and had no caries, restoration, fractures, or cracks were selected for this study...
January 15, 2018: Acta Odontologica Scandinavica
Qiang Zhang, Jing Ma, Haiqing Liu, Duolong He, Lilin Chen, Haikun Wu, Hong Jiang, Qing Lu, Shenglu Bai
To explore the pathologies of Kashin-Beck disease (KBD) and KBD accompanied with dental fluorosis (DF), we conducted a comparative analysis of gene expression profiles. 12 subjects were recruited, including 4 KBD patients, 4 patients with KBD and DF and 4 healthy subjects. Genome-wide expression profiles from their peripheral blood mononuclear cells were evaluated by customized oligonucleotide microarray. R programming software was used for the microarray data analysis followed by functional enrichment analysis through KOBAS...
January 9, 2018: Scientific Reports
M M Patil, Bhavana B Lakhkar, Shailaja S Patil
Fluoride was identified to have caries preventive properties and was widely used for fluoridation of water since 1940, especially in developed countries. After this there was sudden increase in the use of fluorides in food items and in oral medicinal products like toothpastes and mouth washes. Inadvertent use of above has lead to increase in fluorosis as a public health problem. In many places high fluorides are naturally present in earth crust leading to high water fluoride content increasing the risk of fluorosis...
January 3, 2018: Indian Journal of Pediatrics
Pradeep Bhagavatula, Alexandra Curtis, Barbara Broffitt, Karin Weber-Gasparoni, John Warren, Steven M Levy
OBJECTIVES: To examine the relationships between fluoride intake levels and fluorosis of late-erupting permanent teeth. METHODS: The current study used information collected from 437 children in the longitudinal Iowa Fluoride Study. Participants' fluoride intake information was collected using questionnaires from birth to age 10 years. Estimated mean daily fluoride intake was categorized into low, moderate, and high intake tertiles for each age interval (2-5, 5-8, and 2-8 years)...
December 29, 2017: Journal of Public Health Dentistry
Maya Ramesh, N Malathi, K Ramesh, Rita Mary Aruna, Sarah Kuruvilla
Background: High levels of fluoride in the drinking water, especially ground water, results in skeletal fluorosis which involves the bone and major joints. This study was conducted to assess the prevalence of skeletal fluorosis to compare with dental fluorosis in an endemically fluorosed population in the District of Salem, Tamil Nadu. Materials and Methods: Institutional ethical clearance was obtained. A total of 206 patients who reported to the Department of Hematology for blood investigations were the participants in this study...
November 2017: Journal of Pharmacy & Bioallied Sciences
Atul P Daiwile, Saravanadevi Sivanesan, Prashant Tarale, Pravin K Naoghare, Amit Bafana, Devendra Parmar, Krishnamurthi Kannan
Chronic exposure to fluoride has been associated with the development of skeletal fluorosis. Limited reports are available on fluoride induced histone modification. However, the role of histone modification in the pathogenesis of skeletal fluorosis is not investigated. In the present study, we have investigated the role of fluoride induced histone modification on fluorosis development using human osteosarcoma (HOS) cell line. The expression of histone methyltransferases (EHMT1 and EHZ2) and level of global histone trimethylation (H3K9 and H3K27) have been assessed and observed to be increased significantly after fluoride exposure (8 mg/L)...
December 17, 2017: Environmental Toxicology and Pharmacology
Yuan Tian, Yuehai Xiao, Bolin Wang, Chao Sun, Kaifa Tang, Fa Sun
Although fluoride has been widely used in toothpaste, mouthwash, and drinking water to prevent dental caries, the excessive intake of fluoride can cause fluorosis which is associated with dental, skeletal, and soft tissue fluorosis. Recent evidences have drawn the attention to its adverse effects on male reproductive system that include spermatogenesis defect, sperm count loss, and sperm maturation impairment. Fluoride induces oxidative stress through the activation of mitogen activated protein kinase (MAPK) cascade which can lead to cell apoptosis...
December 22, 2017: Bioscience Reports
N I Krikheli, E I Karamysheva, G I Lukina, L V Dubova
The aim of the study was to assess the mineral composition of mixed saliva in dental fluorosis patients undergoing treatment with microabrasion and bleaching. The study included 60 patients aged 18-35 years with various forms of dental fluorosis. Group 1 included 40 patients in which enamel microabrasion was performed, group 2 - 20 patients with microabrasion and bleaching. Mixed saliva composition was analyzed with Olimpus automatic analyzing device. Dental fluorosis treatment in both groups resulted in saliva mineral composition changed associated with enamel demineralization which proves the necessity for calcium and phosphate containing compositions in these treatment groups...
2017: Stomatologii︠a︡
Atta Rasool, Abida Farooqi, Tangfu Xiao, Waqar Ali, Sifat Noor, Oyebamiji Abiola, Salar Ali, Wajid Nasim
Several million people are exposed to fluoride (F-) via drinking water in the world. Current review emphasized the elevated level of fluoride concentrations in the groundwater and associated potential health risk globally with a special focus on Pakistan. Millions of people are deeply dependent on groundwater from different countries of the world encompassing with an elevated level of fluoride. The latest estimates suggest that around 200 million people, from among 25 nations the world over, are under the dreadful fate of fluorosis...
December 19, 2017: Environmental Geochemistry and Health
Aline Lima Leite, Mileni Silva Fernandes, Senda Charone, Gary Milton Whitford, Eric T Everett, Marília Afonso Rabelo Buzalaf
Enamel formation is a complex 2-step process by which proteins are secreted to form an extracellular matrix, followed by massive protein degradation and subsequent mineralization. Excessive systemic exposure to fluoride can disrupt this process and lead to a condition known as dental fluorosis. The genetic background influences the responses of mineralized tissues to fluoride, such as dental fluorosis, observed in A/J and 129P3/J mice. The aim of the present study was to map the protein profile of enamel matrix from A/J and 129P3/J strains...
December 16, 2017: Caries Research
Ali Akbar Mohammadi, Mahmood Yousefi, Mehdi Yaseri, Mohsen Jalilzadeh, Amir Hossein Mahvi
Skeletal fluorosis resulting from high fluoride level in drinking water is a major public health problem. The present study evaluated the association between exposures to drinking water fluoride and skeletal fluorosis in 5 villages of Poldasht County, Iran. All the data and information on the prevalence of bone diseases were obtained from the Health Record Department, Poldasht Health Centre. To obtain the odds ratio of bone disease problem in different risk factors, when considering the cluster effect of rural area, logistic regression in a multilevel model was used...
December 11, 2017: Scientific Reports
Erika Calvano Küchler, Carolina Dea Bruzamolin, Marjorie Ayumi Omori, Marcelo C Costa, Leonardo Santos Antunes, Giovana Daniela Pecharki, Paula Cristina Trevilatto, Alexandre Rezende Vieira, João Armando Brancher
The aim of this study was to evaluate whether genetic polymorphisms in AMELX, AMBN, ENAM, TFIP11, and TUFT1 genes are associated with dental fluorosis (DF). A total of 1,017 children from 2 Brazilian cohorts were evaluated. These populations lived in cities with fluoridation of public water supplies. DF was assessed in erupted permanent teeth using the modified Dean index. The polymorphisms rs946252, rs12640848, rs4694075, rs5997096, and rs4970957 were analyzed by real-time PCR from genomic DNA. Associations between DF, genotype, and allele distribution were evaluated using the χ2 test, with an alpha of 5%...
December 6, 2017: Caries Research
Krishna Kumar Yadav, Neha Gupta, Vinit Kumar, Shakeel Ahmad Khan, Amit Kumar
Fluoride contamination of groundwater is a serious problem in several countries of the world because of the intake of excessive fluoride caused by the drinking of the contaminated groundwater. Geological and anthropogenic factors are responsible for the contamination of groundwater with fluoride. Excess amounts of fluoride in potable water may cause irreversible demineralisation of bone and tooth tissues, a condition called fluorosis, and long-term damage to the brain, liver, thyroid, and kidney. There has long been a need for fluoride removal from potable water to make it safe for human use...
November 27, 2017: Environment International
Maiko Suzuki, Atsushi Ikeda, John D Bartlett
Low-dose fluoride is an effective caries prophylactic, but high-dose fluoride is an environmental health hazard that causes skeletal and dental fluorosis. Treatments to prevent fluorosis and the molecular pathways responsive to fluoride exposure remain to be elucidated. Previously we showed that fluoride activates SIRT1 as an adaptive response to protect cells. Here, we demonstrate that fluoride induced p53 acetylation (Ac-p53) [Lys379], which is a SIRT1 deacetylation target, in ameloblast-derived LS8 cells in vitro and in enamel organ in vivo...
November 28, 2017: Archives of Toxicology
Reza Dehbandi, Farid Moore, Behnam Keshavarzi
The present study is the first attempt to put forward the possible source(s) and health risk assessment of fluoride in Bahabad, central Iran. Fluoride concentrations ranged from 0.22 to 2.35 mg/L and 292-355 mg/kg in the groundwater and soil samples, respectively. Geochemical provenance techniques using major and rare earth elements in soils revealed that local shale is the most probable source rock of fluoride in the area. A two-step chemical fractionation method applied on soil samples demonstrated that residual and water-soluble fractions were the most probable modes of fluoride in soil, whereas exchangeable fraction had a minor role...
November 20, 2017: Chemosphere
Na Wei, Yang-Ting Dong, Jie Deng, Ya Wang, Xiao-Lan Qi, Wen-Feng Yu, Yan Xiao, Jian-Jiang Zhou, Zhi-Zhong Guan
Expressions of N-methyl-d-aspartic acid receptors (NMDARs) in the brains of rats and primary neurons exposed to high fluoride were investigated. Sprague-Dawley rats were divided randomly into a fluorosis group (50ppm fluoride in the drinking water for 6 months) and controls (<0.5ppm fluoride) and the offspring from these rats sacrificed on postnatal days 1, 7, 14, 21 and 28. The primary cultured neurons from the hippocampus of neonatal rats were treated with 5 and 50ppm fluoride for 48h. NMDAR subunits at protein or mRNA levels were quantified by Western blotting or real-time PCR...
January 2018: Journal of Trace Elements in Medicine and Biology
Shivani Arora, Jayanth V Kumar, Mark Eric Moss
OBJECTIVES: There are reports showing higher prevalence of enamel fluorosis among African-American children. This study was conducted to assess whether the effect of water fluoride level on enamel fluorosis is different among different race/ethnicity groups among US school children. METHODS: Data from the National Survey of Oral Health of US School Children 1986-1987 were analyzed to determine the prevalence of enamel fluorosis among 7-17 year-old children. The association between race/ethnicity and enamel fluorosis was examined using logistic regression modeling after controlling for potential confounders age, gender, water fluoridation, other sources of fluoride, and region of residence...
November 24, 2017: Journal of Public Health Dentistry
Anand Verma, Bharatesh K Shetty, Vasudeva Guddattu, Mehul K Chourasia, Prachi Pundir
BACKGROUND: Fluorosis, caused by ingestion of excessive amount of fluoride through food or water, is a major public health problem in India. This study was undertaken to quantify the dental fluorosis burden among school going adolescents and to find factors associated with dental fluorosis in Kolar taluka, Karnataka, India. METHODS: A total of 1026 high school adolescents (12-17 years) were enrolled from different schools selected by stratified sampling method. Dental examination was done to record Dean's fluorosis index, and socio-demographic, food consumption and oral hygiene data were recorded using a pre-tested structured questionnaire...
April 4, 2017: Environmental Health and Preventive Medicine
Hongrui Guo, Ping Kuang, Qin Luo, Hengmin Cui, Huidan Deng, Huan Liu, Yujiao Lu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao
Exposure to high fluorine can cause toxicity in human and animals. Currently, there are no systematic studies on effects of high fluorine on blood cellular immunity and humoral immunity in mice. We evaluated the alterations of blood cellular immunity and humoral immunity in mice by using flow cytometry and ELISA. In the cellular immunity, we found that sodium fluoride (NaF) in excess of 12 mg/Kg resulted in a significant decrease in the percentages of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) T lymphocytes in the peripheral blood...
October 17, 2017: Oncotarget
Haolan Yu, Ningning Jiang, XiuHua Yu, Zhitao Zhao, Xiuyun Zhang, Hui Xu
Studies that have focused on the role TGFβ signaling plays in osteoclast activity are gradually increasing; however, literature is rare in terms of fluorosis. The aim of this study is to observe the role the TβR1/Smad3 pathway plays in fluoride regulating cellsosteoclast-like cells that are under the treatment of TGFβ receptor 1 kinase. The RANKL-mediated osteoclast-like cells from RAW264.7 cells were used as osteoclast precursor model. The profile of miRNA expression in fluoride-treated osteoclast-like cells exhibited 303 upregulated miRNAs, 61 downregulated miRNAs, and further drew 37 signaling pathway maps by KEGG and Biocarta pathway enrichment analysis...
November 7, 2017: Toxicology
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