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https://www.readbyqxmd.com/read/28626284/near-infrared-imaging-of-enamel-hypomineralization-due-to-developmental-defects
#1
Robert C Lee, Andrew Jang, Daniel Fried
The increasing prevalence of mild hypomineralization due to developmental defects on tooth surfaces poses a challenge for caries detection and caries risk assessment and reliable methods need to be developed to discriminate such lesions from active caries lesions that need intervention. Previous studies have demonstrated that areas of hypomineralization are typically covered with a relatively thick surface layer of highly mineralized and transparent enamel similar to arrested lesions. Seventy-six extracted human teeth with mild to moderate degrees of suspicious fluorosis were imaged using near-infrared reflectance and transillumination...
January 28, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28614533/effect-of-fluoride-on-salivary-immunoglobulins-and-sialic-acid
#2
Kadriye Görkem Ulu Güzel, Zuhal Kirzioğlu, Ali Kudret Adiloğlu, Münciye Semra Özay Ertürk
Objective: The aim of our study was to evaluate the effect of fluoride on salivary immunoglobulin and sialic acid levels in children with dental fluorosis and healthy teeth who live in places with high fluoride concentration in drinking water. Method: Fifty-one (51) healthy children between 6 and 12 years old with no caries were randomly selected from primary schools enrolled in the dental-care program operated by the Department of Pediatric Dentistry. The children were divided into two groups: group I comprised 26 children with dental fluorosis [Thylstrup-Fejerskov Dental Fluorosis Index (TFI) = 4] who lived in Isparta (2...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28600727/evaluation-of-acidity-in-late-permian-outcrop-coals-and-its-association-with-endemic-fluorosis-in-the-border-area-of-yunnan-guizhou-and-sichuan-in-china
#3
Xiuping Hong, Handong Liang, Yufa Zhang
The junction area of Yunnan, Guizhou, and Sichuan provinces is the heaviest coal-burning endemic fluorosis zones in China. To better understand the pathogenicity of endemic fluorosis in this area, 87 coal samples from the late Permian outcrop or semi-outcrop coal seams were collected in eight counties of the junction area of Yunnan, Guizhou, and Sichuan provinces. The total fluorine and sulfate content, etc. in the coal was determined using combustion-hydrolysis/fluoride-ion-selective electrode method and ion chromatography, respectively...
June 9, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28595096/occurrence-and-mobility-of-toxic-elements-in-coals-from-endemic-fluorosis-areas-in-the-three-gorges-region-sw-china
#4
Yan Xiong, Tangfu Xiao, Yizhang Liu, Jianming Zhu, Zengping Ning, Qingxiang Xiao
Fluorine (F) is a topic of great interest in coal-combustion related endemic fluorosis areas. However, little extent research exists regarding the environmental geochemistry of toxic elements that are enriched in coals and coal wastes in traditional endemic fluorosis areas, particularly focusing on their occurrences and mobilities during the weathering-leaching processes of coals and coal wastes in the surface environment. This paper addressed the issue of toxic elements in coals and coal wastes in the Three Gorges Region, Southwest (SW) China, where endemic fluorosis has historically prevailed, and investigated the distribution, occurrence, mobility features, and associated potential health risks...
June 5, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28579140/alteration-of-paraoxonase-arylesterase-and-lactonase-activities-in-people-around-fluoride-endemic-area-of-tamil-nadu-india
#5
Mani Arulkumar, Raji Vijayan, Sakayanathan Penislusshiyan, Palanivel Sathishkumar, Jayaraman Angayarkanni, Thayumanavan Palvannan
BACKGROUND: Toxicity due to excess fluoride concentration in drinking water is of great concern in people who rely only on the ground water as their water source in many region of the world. METHODS: We collected samples and examined the toxicity of fluoride in a population residing at Salem, Dharmapuri and Krishnagiri districts of Tamil Nadu, India and measured HDL bound enzyme (PON1), erythrocyte membrane bound enzymes (acetylcholinesterase, AChE) and adenosine 5' triphosphatase (ATPases), plasma enzyme (butyrylcholinesterase, BChE) and rate limiting enzyme in heme biosynthesis (delta aminolevulinic acid dehydratase, δ-ALAD) activities...
June 1, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28573842/caries-prevalence-and-treatment-needs-in-young-people-in-portugal-the-third-national-study
#6
R Calado, C S Ferreira, P Nogueira, P Melo
OBJECTIVE: To evaluate caries prevalence and dental treatment needs in Portuguese children and teenagers, as well as fluorosis prevalence in 12-year-old children, in order to address public oral health program strategies. PARTICIPANTS: A representative stratified random cluster sample of 3,710 participants of 6, 12, and 18 years old was selected. A questionnaire was applied to determine sociodemographic data and some oral health determinants. The clinical examination was based on the ICDAS criteria, then adapted to DMFS index, and Dean's index for fluorosis...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28573833/factors-affecting-dental-fluorosis-in-low-socioeconomic-status-children-in-mexico
#7
N Pérez-Pérez, M E Irigoyen-Camacho, A S Boges-Yañez
OBJECTIVE: To assess the association between dental fluorosis and maternal education in schoolchildren of medium and low socioeconomic status in a low income region of Mexico. DESIGN: Cross-sectional study. SETTINGS: Public schools in the south-central region of Oaxaca, Mexico where the mean fluoride water concentration was 1.01 mg/L (SD 0.21; range 0.71-1.40). Fluoridated salt (200mgF/kg) was available in the region. PARTICIPANTS: 794 schoolchildren...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28553235/4-phenylbutyrate-mitigates-fluoride-induced-cytotoxicity-in-alc-cells
#8
Maiko Suzuki, Eric T Everett, Gary M Whitford, John D Bartlett
Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28537367/prevalence-and-severity-of-dental-fluorosis-in-four-english-cities
#9
I A Pretty, N Boothman, J Morris, L MacKay, Z Liu, M McGrady, M Goodwin
Objective: To assess the prevalence and severity of dental fluorosis in four city-based populations using a robust photographic method with TF index reporting; and to record the aesthetic satisfaction scores of children in all four cities. Basic research design: Cross sectional epidemiological survey (surveillance). Participants: 1,904 children aged 11-14 years, in four English cities. Interventions: Two cities were served by community water fluoridation schemes supplying water at 1mg/l F...
December 2016: Community Dental Health
https://www.readbyqxmd.com/read/28535503/determining-an-upper-reference-value-for-the-urinary-fluoride-creatinine-ratio-in-healthy-children-younger-than-7-years
#10
F Vida Zohoori, A Maguire
The urinary fluoride/creatinine ratio (UF/Cr) in a spot urine sample could be a useful systemic F exposure monitoring tool. No reference value for UF/Cr currently exists, therefore this study aimed to establish an upper reference value for a UF/Cr, corresponding to excessive systemic F exposure, i.e., >0.07 mg F/kg body weight (b.w.)/day, in children. Subsidiary aims were to examine the relationship between (i) total daily F intake (TDFI) and 24-h urinary F excretion (DUFE); (ii) DUFE and UF/Cr, and (iii) TDFI and UF/Cr...
May 24, 2017: Caries Research
https://www.readbyqxmd.com/read/28493183/geochemical-characterization-of-fluoride-in-water-table-salt-active-sediment-rock-and-soil-samples-and-its-possible-relationship-with-the-prevalence-of-enamel-fluorosis-in-children-in-four-municipalities-of-the-department-of-huila-colombia
#11
Stefania Martignon, Mario Omar Opazo-Gutiérrez, Möritz Velásquez-Riaño, Iván Rodrigo Orjuela-Osorio, Viviana Avila, Esperanza Angeles Martinez-Mier, María Clara González-Carrera, Jaime Alberto Ruiz-Carrizosa, Blanca Cecilia Silva-Hermida
Fluoride is an element that affects teeth and bone formation in animals and humans. Though the use of systemic fluoride is an evidence-based caries preventive measure, excessive ingestion can impair tooth development, mainly the mineralization of tooth enamel, leading to a condition known as enamel fluorosis. In this study, we investigated the geochemical characterization of fluoride in water, table salt, active sediment, rock and soil samples in four endemic enamel fluorosis sentinel municipalities of the department of Huila, Colombia (Pitalito, Altamira, El Agrado and Rivera), and its possible relationship with the prevalence of enamel fluorosis in children...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28490846/reliability-of-intra-oral-camera-using-teledentistry-in-screening-of-oral-diseases-pilot-study
#12
Kalyana Chakravarthy Pentapati, Preetinanda Mishra, Mehrshad Damania, Siddharth Narayanan, Garima Sachdeva, Geetanshu Bhalla
OBJECTIVE: Reliability of intra-oral camera using teledentistry in screening of oral diseases. METHODOLOGY: A trained and calibrated examiner used intra-oral camera to capture videos of oral cavity along with clinical examination to evaluate caries, plaque, calculus, tooth wear and fluorosis, stains in children. RESULTS: The mean DT and DMFT were significantly higher with use of intra-oral camera than with clinical examination (p = 0.001 and 0...
April 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28484883/delayed-chance-fracture-pattern-injury-in-a-case-of-skeletal-fluorosis
#13
Srikanth Reddy Dumpa, Siddharth N Aiyer, Sreekanth Reddy Rajoli, Ajoy Prasad Shetty, S Rajasekaran
PURPOSE: To document a rare complication of a delayed 'chance fracture pattern'-type injury through the proximal end of a pedicle screw construct in the clinical scenario of skeletal fluorosis. METHODS: A 72-year-old man with fluorosis presented following a fall which resulted in a T12-L1 fracture. Investigations revealed an unstable three-column injury, so the patient was treated with surgical stabilisation using pedicle screw fixation from T11 to L2. He presented 1 month following surgery with worsening back pain...
May 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28462439/ameliorative-effect-of-ve-igf-i-and-hcg-on-the-fluoride-induced-testosterone-release-suppression-in-mice-leydig-cells
#14
Yuxiang Yu, Yongli Han, Ruiyan Niu, Jundong Wang, Ram Kumar Manthari, Mohammad Mehdi Ommati, Zilong Sun
Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). These NaF-induced alterations include decreased cell proliferation, steroidogenesis, and relative gene expression...
May 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28429284/foxo1-attenuates-naf-induced-apoptosis-of-ls8-cells-through-the-jnk-and-mitochondrial-pathways
#15
Juedan Li, Lin Zhao, Xiaomeng Zhao, Peng Wang, Yan Liu, Jianping Ruan
Fluoride-induced ameloblast apoptosis is a key event in dental fluorosis development. Forkhead box o1 (Foxo1) is a transcription factor involved in cell apoptosis. The present study aims to investigate the effect of Foxo1 on ameloblast apoptosis induced by fluoride in vitro and to explore its possible mechanism. Ameloblast-like cells (LS8 cells) were exposed to various concentrations of NaF for up to 48 h. Foxo1 activation was modulated using lentiviral vectors, and cell apoptosis was measured by flow cytometry...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28411405/biomarkers-of-chronic-fluoride-exposure-in-groundwater-in-a-highly-exposed-population
#16
Tewodros Rango, Avner Vengosh, Marc Jeuland, Gary M Whitford, Redda Tekle-Haimanot
This study examined the relation between fluoride (F(-)) concentrations in fingernail clippings and urine and the prevalence and severity of enamel fluorosis (EF) among Ethiopian Rift Valley populations exposed to high levels of F(-) in drinking water. The utility of fingernail clippings as a biomarker for F(-) exposure and EF was also assessed for the first time in a high-F(-) region. The study recorded the EF status of 386 individuals (10 to 50years old), who consume naturally contaminated groundwater with widely varying F(-) concentration (0...
April 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28405851/fluoride-induces-neuroinflammation-and-alters-wnt-signaling-pathway-in-bv2-microglial-cells
#17
Rui Chen, Lian-Dong Zhao, Hong Liu, Hui-Hua Li, Chao Ren, Peng Zhang, Ke-Tai Guo, Hong-Xi Zhang, De-Qin Geng, Cai-Yi Zhang
Fluoride is a common element in nature and our daily life, and excessive intake of this element can cause fluorosis and irreversible brain damage. The toxic effects of fluoride on the central nervous system may be attributed to the release of inflammatory cytokines and ROS. GSK3β is a key protein that modulates NF-κB activity and inflammatory cytokine levels and plays an important role in the Wnt signaling pathway. In this study, we found that fluoride altered the inflammatory status and oxidative stress by inhibiting Wnt signaling pathway activity...
April 12, 2017: Inflammation
https://www.readbyqxmd.com/read/28386112/sodium-fluoride-induces-nephrotoxicity-via-oxidative-stress-regulated-mitochondrial-sirt3-signaling-pathway
#18
Chao Song, Beibei Fu, Jingcheng Zhang, Jiamin Zhao, Mengke Yuan, Wei Peng, Yong Zhang, Haibo Wu
Accumulation of mitochondrial reactive oxygen species (mROS) has been implicated in the pathogenesis of fluorosis. As the main mitochondrial deacetylase, SIRT3 is closely associated with oxidative stress. To investigate the role of SIRT3 in response to sodium fluoride (NaF)-induced nephrotoxicity. Our results showed that NaF treatment impaired mitochondrial ultrastructure, decreased cell viability and increased apoptosis in TCMK-1 cells. Oxidative stress, detected by mROS and 8-Hydroxy-2'-deoxyguanosine (8-OHdG) were higher in NaF-treated cells, accompanied by decreased level of reduced glutathione (GSH)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378104/the-role-of-parental-rearing-practices-and-family-demographics-on-oral-health-related-quality-of-life-in-children
#19
S Kumar, M J Zimmer-Gembeck, J Kroon, R Lalloo, N W Johnson
OBJECTIVES: To evaluate the direct and indirect (via oral health-related behaviour) effects of parental rearing practices on children's Oral Health-Related Quality of Life (OHRQoL) within a family-focused, comprehensive predictive model. METHODS: Participants were 11- to 14-year-old children and their parents living in Telangana State, India (N = 1130). Children were clinically assessed for dental caries, gingivitis, oral hygiene status, fluorosis, and malocclusion, and completed a self-administered questionnaire on oral health-related behaviour and OHRQoL...
April 4, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28362308/hydrochemical-characteristics-of-natural-water-and-selenium-rich-water-resources-in-the-northern-daba-mountains-china
#20
Chao Zhao, Kunli Luo, Yajun Du, Yuan Tian, Jie Long, Xiaofeng Zhao, Shixi Zhang
The Northern Daba Mountains (NDM) of Shaanxi Province, China, are a well-known selenium (Se)-rich area, and the area is also known for endemic fluorine (F) and arsenic (As) poisoning. In order to study the hydrochemical characteristics and trace element contents of the natural waters of this region, 62 water samples were collected from Lan'gao area in the NDM. The hydrochemical composition was principally characterized by Ca·Mg-HCO3·SO4. F and As concentrations ranged from 0.01 to 0.67 mg/L and from 0.33 to 6...
April 2017: Journal of Water and Health
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