keyword
https://read.qxmd.com/read/38536563/machine-learning-in-risk-prediction-of-continuous-renal-replacement-therapy-after-coronary-artery-bypass-grafting-surgery-in-patients
#1
JOURNAL ARTICLE
Qian Zhang, Peng Zheng, Zhou Hong, Luo Li, Nannan Liu, Zhiping Bian, Xiangjian Chen, Hengfang Wu, Sheng Zhao
OBJECTIVES: This study aimed to develop machine learning models for risk prediction of continuous renal replacement therapy (CRRT) following coronary artery bypass grafting (CABG) surgery in intensive care unit (ICU) patients. METHODS: We extracted CABG patients from the electronic medical record system of the hospital. The endpoint of this study was the requirement for CRRT after CABG surgery. The Boruta method was used for feature selection. Seven machine learning algorithms were developed to train models and validated using 10 fold cross-validation (CV)...
March 27, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#2
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38533293/a-new-dosing-frontier-retrospective-assessment-of-effluent-flow-rates-and-residual-renal-function-among-critically-ill-patients-receiving-continuous-renal-replacement-therapy
#3
JOURNAL ARTICLE
Damini Lakshmipathy, Xiaoyi Ye, Joseph L Kuti, David P Nicolau, Tomefa E Asempa
OBJECTIVES: In 2020, cefiderocol became the first Food and Drug Administration-approved medication with continuous renal replacement therapy (CRRT) dosing recommendations based on effluent flow rates ( Q E ). We aimed to evaluate the magnitude and frequency of factors that may influence these recommendations, that is, Q E intrapatient variability and residual renal function. DESIGN: Retrospective observational cohort study. SETTING: ICUs within Hartford Hospital (890-bed, acute-care hospital) in Connecticut from 2017 to 2023...
April 2024: Critical care explorations
https://read.qxmd.com/read/38532586/-evaluation-of-safety-of-early-enteral-nutrition-in-patients-with-severe-intra-abdominal-infection-and-intestinal-fistulas
#4
JOURNAL ARTICLE
T Xie, C Chen, D L Yang, W Y Wang, F Chen, Y N He, P F Wang, Y S Li
Objective: To evaluate the safety of early enteral nutrition (EEN) support in patients with severe intra-abdominal infection and intestinal fistulas. Methods: This was a retrospective cohort study. We collected relevant clinical data of 204 patients with severe intra-abdominal infection and intestinal fistulas who had been managed in the No. 1 Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University between 1 January 2017 and 1 January 2020. The patients were allocated to EEN or delayed enteral nutrition (DEN) groups depending on whether enteral nutrition had been instituted within 48 hours of admission to the intensive care unit...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532304/5-year-results-from-a-prospective-single-arm-european-trial-on-decellularized-allografts-for-aortic-valve-replacement-the-arise-study-and-arise-registry-data
#5
JOURNAL ARTICLE
Alexander Horke, Igor Tudorache, Günther Laufer, Martin Andreas, Jose Luis Pomar, Daniel Pereda, Eduard Quintana, Marta Sitges, Bart Meyns, Filip Rega, Mark Hazekamp, Robert Cesnjevar, Martin Oliver Schmiady, John Pepper, Ulrich Rosendahl, Artur Lichtenberg, Dmytro Stadnik, Ramadan Jashari, Dietmar Boethig, Dmitry Bobylev, Murat Avsar, Arjang Ruhparwar, Axel Haverich, Serghei Cebotari, Samir Sarikouch
BACKGROUND: Decellularized aortic homografts (DAH) were introduced as a new option for aortic valve replacement (AVR) for young patients. METHODS: A prospective, EU-funded, single-arm, multicentre study in 8 centers evaluating non-cryopreserved DAH for AVR. RESULTS: 144 patients (99 male) were prospectively enrolled in the ARISE Trial between 10/2015 and 10/2018 with a median age of 30.4 yrs, (IQR 15.9-55.1). 45% had undergone previous cardiac operations, with 19% having two or more previous procedures...
March 26, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38530631/extra-corporeal-non-liver-transplant-therapies-for-acute-liver-failure-focus-on-plasma-exchange-and-continuous-renal-replacement-therapy
#6
REVIEW
Uday Zachariah, Balakrishnan Vijayalekshmi, Smita M Matthai, Ashish Goel, Chundamannil E Eapen
The acute inflammatory milieu in patients with acute liver failure (ALF) results in 'toxic' blood in these patients. In vitro experiments have shown that the plasma obtained from ALF patients is toxic to rabbit hepatocytes and inhibits regeneration of rat hepatocytes. Treatments such as plasma exchange and continuous renal replacement therapy to cleanse the blood have improved survival in ALF patients. In the liver microcirculation, the exchange of fluid across fenestrae in liver sinusoidal endothelial cells (LSECs) is vital for proper functioning of hepatocytes...
March 26, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38527053/impact-of-extracorporeal-membrane-oxygenation-related-complications-on-in-hospital-mortality
#7
JOURNAL ARTICLE
Eunae Byun, Pil Je Kang, Sung Ho Jung, Seo Young Park, Sang Ah Lee, Tae-Won Kwon, Yong-Pil Cho
INTRODUCTION: Although extracorporeal membrane oxygenation (ECMO) is a well-established treatment for supporting severe cardiopulmonary failure, the morbidity and mortality of patients requiring ECMO support remain high. Evaluating and correcting potential risk factors associated with any ECMO-related complications may improve care and decrease mortality. This study aimed to assess the predictors of ECMO-related vascular and cerebrovascular complications among adult patients and to test the hypothesis that ECMO-related complications are associated with higher in-hospital mortality rates...
2024: PloS One
https://read.qxmd.com/read/38525995/epidemiology-and-treatment-outcome-of-anca-associated-vasculitis-in-south-korea-a-nationwide-population-based-cohort-study
#8
JOURNAL ARTICLE
Jun Won Park, Jihun Song, Seulggie Choi, Sun Jae Park, Sang Min Park, Eun Young Lee
OBJECTIVES: To investigate the epidemiological features of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in South Korea. METHODS: We identified the index cases of GPA and MPA using the 2010-2018 Korean National Health Insurance Service database and the Rare Intractable Disease registry for the entire Korean population. Each disease's incidence and prevalence rates and trends over time were analysed. To assess the impact of disease on morbidity and mortality, a comparator group comprising the general population was established using nearest-neighbour matching by age, sex, income, and comorbidity index, at a 5:1 ratio...
March 25, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38524636/semaglutide-as-a-potential-therapeutic-alternative-for-hnf1b-mody-a-case-study
#9
Angham Almutair, Beshaier Almulhem
Maturity-onset diabetes of the young (MODY) is a grouping of monogenic disorders. It is characterized by dominantly inherited, non-insulin-dependent diabetes. MODY is relatively rare, encompassing up to 3.5% in those diagnosed under 30 years of age. Specific types are most commonly treated with sulfonylurea, particularly those identified as HNF4A-MODY and HNF1A-MODY. HNF1B-MODY is another type that is most frequently managed with insulin therapy but lacks a defined precision treatment. We present an 18-year-old, non-obese female patient diagnosed with HNF1B-MODY...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38524548/sequential-respiratory-support-in-septic-patients-undergoing-continuous-renal-replacement-therapy-a-study-based-on-mimic-iii-database
#10
JOURNAL ARTICLE
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
OBJECTIVE: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT). METHODS: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524089/bradycardia-renal-failure-atrioventricular-block-shock-and-hyperkalemia-brash-syndrome-emergence-in-a-unique-intersection-of-covid-19-and-end-stage-renal-disease-a-case-report
#11
Tutul Chowdhury, Sindhu C Pokhriyal, Uma Gupta, Kalendra Kunwar, Kiran Hashmi, Sauraj Devkota, Morris Kopyt, Andleeb Sherazi
Bradycardia, renal failure, atrioventricular (AV) block, shock, and hyperkalemia (BRASH) syndrome is a rare clinical entity that poses challenges for healthcare practitioners. It is characterized by bradycardia, renal failure, atrioventricular (AV) obstruction, shock, and hyperkalemia. This case is an interesting instance of BRASH syndrome in the setting of COVID-19 infection and end-stage renal disease (ESRD). Initial laboratory results revealed macrocytic anemia, renal dysfunction, acidosis, and mild hyponatremia, along with hyperkalemia...
February 2024: Curēus
https://read.qxmd.com/read/38523856/encephalopathy-after-a-high-dose-dexamethasone-suppression-test-in-a-woman-with-x-linked-ornithine-transcarbamylase-deficiency
#12
Hyunho Seol, Yoon Hee Hong, Min Ji Jeon
BACKGROUND/OBJECTIVE: The high-dose dexamethasone suppression test is a common and usually benign endocrine procedure. We report a patient with ornithine transcarbamylase deficiency (OTCD) who developed hyperammonemic encephalopathy after a high-dose dexamethasone suppression test. CASE REPORT: A 46-year-old woman with a 1.3-cm right adrenal incidentaloma causing mild autonomous cortisol secretion underwent a high-dose dexamethasone suppression test for confirming adrenocorticotropic hormone independency...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38522017/health-literacy-self-efficacy-and-health-outcomes-of-patients-undergoing-haemodialysis-mediating-role-of-self-management
#13
JOURNAL ARTICLE
Shu-Hua Hsu, Yu-Li Lin, Malcolm Koo, Debra K Creedy, Ying Tsao
BACKGROUND: Health literacy, self-efficacy and self-management are known to influence health-related well-being. However, the precise influence of self-management, health literacy and self-efficacy on health outcomes in Asian countries is under-researched. OBJECTIVES: To examine the impact of health literacy and self-efficacy (independent variables) and self-management (mediator) on patients' health outcomes (dependent variable). DESIGN: An observational, cross-sectional design was conducted between 1 March 2022 and 31 August 2022...
March 24, 2024: Journal of Renal Care
https://read.qxmd.com/read/38521927/spontaneous-tumor-lysis-syndrome-stls-during-biopsy-for-burkitt-lymphoma-a-case-report
#14
JOURNAL ARTICLE
Sirui Pan, Qiyang Shen, Jianfeng Zhou, Tao Li
BACKGROUND: Tumor lysis syndrome (TLS) is a hematologic oncological emergency characterized by metabolic and electrolyte imbalances. On breakdown of tumor cells, enormous amounts of potassium, phosphate, and nucleic acids are released into systemic circulation. TLS mainly occurs during chemotherapy. However, there are rare incidences of spontaneous tumor lysis syndrome (STLS) prior to commencement of therapy. CASE PRESENTATION: In the case being reported, the child had just undergone a biopsy...
March 23, 2024: BMC Pediatrics
https://read.qxmd.com/read/38515712/safety-efficacy-and-pharmacokinetics-of-nirmatrelvir-and-ritonavir-in-patients-with-severe-covid-19-and-renal-impairment-a-case-report
#15
Ren Zheng, Xudong Fan, Feng Zhou, Xiqian Ye, Jing Sun, Junjie Cheng, Yuan Yuan, Yu Wang, Xinjun Cai, Anqi Wei
Nirmatrelvir/ritonavir (N/r) has received emergency use authorization for mild-to-moderate COVID-19 treatment in adult and pediatric patients (aged and weighing at least 12 years and 40 kg, respectively) presenting positive direct SARS-CoV-2 viral testing results and a high risk of disease progression to severe COVID-19. However, information remains limited concerning the corresponding drug safety, efficacy, and pharmacokinetics in patients with severe renal impairment. In this study, we present the case of a 91-year-old Chinese man who, despite exhibiting recurrent positive SARS-CoV-2 results and progression to severe COVID-19, was treated with N/r...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38515334/new-onset-mental-illness-and-long-term-survival-in-survivors-of-critical-illness-population-based-cohort-study-in-south-korea
#16
JOURNAL ARTICLE
Tak Kyu Oh, Hye Yoon Park, In-Ae Song
BACKGROUND: Critical care unit (CCU) survivors have a high risk of developing mental illness. AIMS: We aimed to examine the incidence and associated factors of newly developed mental illness among CCU survivors of critical illness. Moreover, we examined the association between newly developed mental illness and 2-year all-cause mortality. METHOD: All adult patients (≥20 years) who were admitted to the CCU during hospitalisation between 2010 and 2018 and survived for 1 year were defined as CCU survivors and were included in this nationwide population-based cohort study...
March 22, 2024: BJPsych Open
https://read.qxmd.com/read/38511997/continuous-renal-replacement-therapy-current-state-and-future-directions-for-worldwide-practice
#17
JOURNAL ARTICLE
Katja M Gist, Dana Y Fuhrman, Akash Deep, Taiki Haga, Demet Demirkol, Michael J Bell, Ayse Akcan-Arikan
No abstract text is available yet for this article.
March 21, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38511994/renin-levels-and-angiotensin-ii-responsiveness-in-vasopressor-dependent-hypotension
#18
JOURNAL ARTICLE
Emily J See, Anis Chaba, Sofia Spano, Akinori Maeda, Caroline Clapham, Louise M Burrell, Jasmine Liu, Monique Khasin, Grace Liskaser, Glenn Eastwood, Rinaldo Bellomo
OBJECTIVES: The relationship between renin levels, exposure to renin-angiotensin system (RAS) inhibitors, angiotensin II (ANGII) responsiveness, and outcome in patients with vasopressor-dependent vasodilatory hypotension is unknown. DESIGN: We conducted a single-center prospective observational study to explore whether recent RAS inhibitor exposure affected baseline renin levels, whether baseline renin levels predicted ANGII responsiveness, and whether renin levels at 24 hours were associated with clinical outcomes...
March 21, 2024: Critical Care Medicine
https://read.qxmd.com/read/38510777/acute-kidney-injury-and-ecmo-two-sides-of-the-same-coin
#19
EDITORIAL
Sachin Gupta, Deeksha Singh Tomar
How to cite this article: Gupta S, Tomar DS. Acute Kidney Injury and ECMO: Two Sides of the Same Coin. Indian J Crit Care Med 2024;28(1):3-4.
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510775/the-use-of-sustained-low-efficiency-dialysis-in-the-treatment-of-sepsis-associated-acute-kidney-injury-in-a-low-income-country-a-prospective-cohort-study
#20
JOURNAL ARTICLE
Abdalla Kamal Abdalla Taha, Mazin Mohammed Taha Shigidi, Nazik Mahmoud Abdulfatah, Rajabia Khidir Alsayed
BACKGROUND: Limited data are available regarding the management and outcomes of patients with sepsis-associated acute kidney injury (SA-AKI) requiring dialysis in Sudan. Continuous renal replacement therapy (CRRT) is a highly favored treatment modality in such patients. However, it stays unavailable and expensive treatment in most low-income countries. We aimed to evaluate the use of sustained low-efficiency dialysis (SLED) in the treatment of hemodynamically unstable patients with SA-AKI admitted to the intensive care unit (ICU)...
January 2024: Indian Journal of Critical Care Medicine
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