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Neuropathic syndrome

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https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#1
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29770251/review-of-the-neurological-benefits-of-phytocannabinoids
#2
REVIEW
Joseph Maroon, Jeff Bost
Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol (Δ9-THC) are the most studied extracts from cannabis sativa subspecies hemp and marijuana. CBD and Δ9-THC interact uniquely with the endocannabinoid system (ECS). Through direct and indirect actions, intrinsic endocannabinoids and plant-based phytocannabinoids modulate and influence a variety of physiological systems influenced by the ECS...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29750060/fascial-preadipocytes-another-missing-piece-of-the-puzzle-to-understand-fibromyalgia
#3
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon
Fibromyalgia (FM) syndrome is a chronic condition causing pain, affecting approximately 0.5%-6% of the developed countries' population, and on average, 2% of the worldwide population. Despite the large amount of scientific literature available, the FM etiology is still uncertain. The diagnosis is based on the clinical presentation and the severity of the symptomatology. Several studies pointed out pathological alterations within the central nervous system, suggesting that FM could originate from a central sensitization of the pain processing centers...
2018: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29742719/cauda-equina-syndrome-following-an-uneventful-spinal-anesthesia-in-a-patient-undergoing-drainage-of-the-bartholin-abscess-a-case-report
#4
Waldo Merino-Urrutia, Milca Villagrán-Schmidt, Priscilla Ulloa-Vásquez, Rubén Carrasco-Moyano, Alberto Uribe, Nicoleta Stoicea, Sergio D Bergese
RATIONALE: Neuraxial anesthesia is a commonly used type of regional anesthesia. Cauda equina syndrome is an unusual and severe complication of neuraxial anesthesia, and is caused by damage to the sacral roots of the neural canal. We present a case of cauda equina syndrome following spinal anesthesia in a patient who underwent Bartholin abscess drainage. PATIENT CONCERNS: A 23-year old female scheduled to undergo surgical drainage of Bartholin abscess. Spinal anesthesia was performed with bupivacaine and fentanyl...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739958/trpv1-and-the-mcp-1-ccr2-axis-modulate-post-uti-chronic-pain
#5
John M Rosen, Ryan E Yaggie, Patrick J Woida, Richard J Miller, Anthony J Schaeffer, David J Klumpp
The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and its receptor TLR4 are required for post-UTI chronic pain development. However, downstream mechanisms of post-UTI chronic pelvic pain remain unclear. Because the TRPV1 and MCP-1/CCR2 pathways are implicated in chronic neuropathic pain, we explored their role in post-UTI chronic pain. Mice were infected with the E. coli strain SΦ874, known to produce chronic allodynia, and treated with the TRPV1 antagonist capsazepine...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729775/cancer-pain-syndromes
#6
REVIEW
Russell K Portenoy, Ebtesam Ahmed
Patients with cancer experience many acute and chronic pain syndromes, the identification of which may be helpful in the assessment and treatment of pain. Syndromes are defined by the relationship with the cancer, the pain pathophysiology, and the clinical characteristics of the pain. The most common pain syndromes are directly related to the tumor; bone pain syndromes are most common. Neuropathic pain syndromes may involve cancer-related injury at any level of the peripheral nervous system. Treatment-related pain syndromes may follow any type of antineoplastic therapy...
June 2018: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29726290/alpha-lipoic-acid-in-obstetrics-and-gynecology
#7
Chiara Di Tucci, Mara Di Feliciantonio, Flaminia Vena, Carmela Capone, Michele Carlo Schiavi, Daniela Pietrangeli, Ludovico Muzii, Pierluigi Benedetti Panici
Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action. A comprehensive literature search was performed in PubMed and Cochrane Library for retrieving articles in English language on the antioxidant and anti-inflammatory effects of ALA in gynecological and obstetrical conditions...
May 4, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29722322/treatment-with-acetyl-l-carnitine-exerts-a-neuroprotective-effect-in-the-sciatic-nerve-following-loose-ligation-a-functional-and-microanatomical-study
#8
Daniele Tomassoni, Lorenzo Di Cesare Mannelli, Vincenzo Bramanti, Carla Ghelardini, Francesco Amenta, Alessandra Pacini
Peripheral neuropathies are chronic painful syndromes characterized by allodynia, hyperalgesia and altered nerve functionality. Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies. Aimed to improve the therapeutic possibilities, this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats. Effects elicited by treatment with acetyl-L-carnitine (ALCAR) in comparison to gabapentin were assessed...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29713421/failed-back-surgery-syndrome-a-review-article
#9
REVIEW
James R Daniell, Orso L Osti
Postsurgical spine syndrome is becoming an increasingly common challenge for clinicians who deal with spinal disorders owing to the expanding indications for spinal surgery and the aging world population. A multidisciplinary approach is most appropriate for patients who are unlikely to benefit from further formal surgical intervention. Anticonvulsant medications are effective in managing neuropathic pain after surgery, whereas opioids are rarely beneficial. Neuromodulation via a surgically implanted dorsal column neurostimulator is gaining popularity owing to its substantial superiority over conventional medical management and/or further surgical intervention...
April 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29710429/clinical-manifestation-of-acute-subacute-and-chronic-low-back-pain-in-different-age-groups
#10
Philipp Hüllemann, Thomas Keller, Maria Kabelitz, Janne Gierthmühlen, Rainer Freynhagen, Thomas Tölle, Julia Forstenpointner, Ralf Baron
BACKGROUND: Low back pain is major health care problem causing tremendous economic cots. METHODS: Clinical manifestation of low back pain (LBP) was characterized in 35,446 patients. We focused on the comparison of the acute, subacute, and chronic LBP stage with regard to patients' age, based on epidemiological and clinical questionnaires (e.g. painDETECT, pain disability index), pain intensity, pain descriptors, and functional impairment. RESULTS: We found that neuropathic components were most frequent in chronic LBP patients at the age of 51-60 years...
April 30, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29707093/pulsed-radiofrequency-as-a-minimally-invasive-treatment-option-in-anterior-cutaneous-nerve-entrapment-syndrome-a-retrospective-analysis-of-26-patients
#11
Robbert C Maatman, Monique A H Steegers, Jan-Willem Kallewaard, Marc R M Scheltinga, Rudi M H Roumen
Background: Chronic abdominal pain is occasionally due to entrapped intercostal nerve endings (ACNES, abdominal cutaneous nerve entrapment syndrome). If abdominal wall infiltration using an anesthetic agent is unsuccessful, a neurectomy may be considered. Pulsed radiofrequency (PRF) is a relatively new treatment option for various chronic pain syndromes. Evidence regarding a beneficial effect of this minimally invasive technique in ACNES is lacking. The aim was to assess the effectiveness of PRF treatment in ACNES patients...
June 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29705015/evaluation-of-postural-tachycardia-syndrome-pots
#12
REVIEW
Brent P Goodman
The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach utilizing a careful clinical history and examination, laboratory, and autonomic testing. This article outlines the importance of a thorough history in identifying mechanism of symptom onset, clinical features, associated clinical conditions or disorders, and factors that may result in symptom exacerbation. The clinical examination involves an assessment of pupillary responses, an evaluation for sudomotor and vasomotor signs, and an assessment for joint hypermobility...
April 22, 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29696046/clinical-features-and-outcome-of-guillain-barr%C3%A3-syndrome-in-children
#13
Jafar Nasiri, Mohamadreza Ghazavi, Omid Yaghini, Mohamad Chaldavi
Objective: There are no reports about the clinical presentations and outcome of Guillain-Barré syndrome (GBS) in our region, therefore, we aimed to report some mentioned findings in children diagnosed with GBS in Isfahan, central Iran. Materials & Methods: In this retrospective study, pediatric diagnosed with GBS referred to Imam Hossein Hospital, the Pediatric Referral Center of Isfahan Province, central Iran were enrolled from 2011-2014. The following data were extracted from the medical files of patients; age, gender, early signs and symptoms of GBS, neurological features, sensory and motor and autonomic involvements, sphincter dysfunction, bulbar muscle involvement, respiratory failure, cranial nerve paralysis, delay time from onset to definite diagnosis and management of GBS and the outcome...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29695418/role-of-complement-in-a-rat-model-of-paclitaxel-induced-peripheral-neuropathy
#14
Jijun Xu, Lingjun Zhang, Mian Xie, Yan Li, Ping Huang, Thomas L Saunders, David A Fox, Richard Rosenquist, Feng Lin
Chemotherapy-induced peripheral neuropathy (CIPN) is a painful and debilitating side effect of cancer chemotherapy with an unclear pathogenesis. Consequently, the available therapies for this neuropathic pain syndrome are inadequate, leading to a significantly reduced quality of life in many patients. Complement, a key component of the innate immune system, has been associated with neuroinflammation, a potentially important trigger of some types of neuropathic pain. However, the role of complement in CIPN remains unclear...
April 25, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29690804/expression-of-macrophage-migration-inhibitory-factor-in-footpad-skin-lesions-with-diabetic-neuropathy
#15
Sun Up Noh, Won-Young Lee, Won-Serk Kim, Yong-Taek Lee, Kyung Jae Yoon
Background Diabetic neuropathy (DN) originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of DN remains unclear. Macrophage migration inhibitory factor (MIF) has been implicated in the onset of neuropathic pain and the development of diabetes. Objective of this study was to observe pain syndromes elicited in the footpad of DN rat model and to assess the contributory role of MIF in the pathogenesis of DN. Methods DN was made in SD rats by streptozotocin (STZ)...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29687213/letter-to-the-editor-insular-stroke-presenting-with-acute-onset-of-pain
#16
Michael Bayat, Allan Bayat
Post-stroke pain is a well-known neuropathic pain syndrome but pain at the onset of stroke is a very rare occurrence. We wish to present a case where a stroke in the insular region caused acute-onset lateralized neuropathic pain.
April 23, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29682461/capsaicin-patch-for-persistent-postoperative-pain-after-thoracoscopic-surgery-report-of-two-cases
#17
Nicola Tamburini, Giacomo Bollini, Carlo Alberto Volta, Giorgio Cavallesco, Pio Maniscalco, Savino Spadaro, Francesco Qurantotto, Riccardo Ragazzi
Effective postoperative pain control after thoracic surgery is a significant clinical issue because it reduces pulmonary complications and accelerates the pace of recovery. Persistent postoperative pain syndrome is a recognized and frequent complication after thoracoscopic surgery. The capsaicin 8% patch contains a high concentration of synthetic capsaicin approved for treatment of peripheral neuropathic pain in adults. Little clinical data exist on the use of capsaicin patch in thoracic persistent postoperative pain syndrome...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29676237/ultramicronized-palmitoylethanolamide-effects-on-sleep-wake-rhythm-and-neuropathic-pain-phenotypes-in-patients-with-carpal-tunnel-syndrome-an-open-label-randomized-controlled-study
#18
Maurizio Evangelista, Vitale Cilli, Rocco De Vitis, Arturo Militerno, Francesco Fanfani
BACKGROUND: Patients with carpal tunnel syndrome often suffer from fragmentary sleep. This study was designed to assess the effectiveness of treatment with ultramicronized palmitoylethanolamide in reducing pain intensity and in improving quality of sleep in patients with neuropathic pain due to carpal tunnel syndrome. METHODS: An open, controlled study was conducted on 42 patients awaiting carpal tunnel syndrome surgery, suffering from sleep disorders and painful symptoms and randomized into two groups...
April 20, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29652305/-efficiency-of-neuromultivit-in-complex-therapy-of-patients-with-rheumatoid-arthritis-associated-with-diabetes-mellitus
#19
L N Eliseeva, A Yu Selimov, A Yu Blednova, Zh Z Otarova, M I Bocharnikova, V S Seredinsky
AIM: To examine the dysregulation of the autonomic nervous system and manifestations of pain syndrome in patients with rheumatoid arthritis combined with diabetes mellitus and the possibility of their correction in patients who receive complex therapy including neurotropic vitamins (neuromultivitis). MATERIAL AND METHODS: One hundred and forty-six patients with rheumatoid disease were examined including 59 patients with diabetes mellitus. RESULTS AND CONCLUSION: When testing for the presence of neuropathic pain syndrome using the diagnostic questionnaire of neuropathic pain (DN4), a greater prevalence of these features was revealed, with a high correlation with the duration of rheumatoid arthritis (r=0,56) and duration of diabetes mellitus (r=0,82)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29623654/tapentadol-extended-release-in-the-treatment-of-severe-chronic-low-back-pain-and-osteoarthritis-pain
#20
REVIEW
Joseph V Pergolizzi, Robert Taylor, Jo Ann LeQuang, Robert B Raffa, John Bisney
Tapentadol is a novel pain reliever with apparently synergistic dual mechanisms of action, capable of addressing both nociceptive and neuropathic components of chronic pain. As an effective analgesic with good tolerability, tapentadol may be appropriate for patients suffering from severe chronic pain associated with low back pain (LBP) or osteoarthritis (OA). Efficacy studies of tapentadol in populations of patients with severe chronic LBP or OA pain suggest that tapentadol is non-inferior to oxycodone. Its tolerability, especially with respect to gastrointestinal (GI) side effects, may be better than that of other strong opioids in clinical trials and analyses of multiple trials...
April 5, 2018: Pain and Therapy
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