keyword
https://read.qxmd.com/read/38383968/demographic-and-clinical-profile-of-1106-adult-soft-tissue-sarcoma-patients-a-single-institutional-prospective-database-experience-from-india
#21
JOURNAL ARTICLE
Jyoti Sharma, Surya V S Deo, Sunil Kumar, Sandeep Bhoriwal, Madhabananda Kar, Adarsh W Barwad, Sanjay Thulkar, Sameer Bakhshi, D N Sharma
BACKGROUND: Adult soft tissue sarcomas (STS) are rare and diverse. Current management is based on limited literature from the West. Therefore, data from different geographical regions is required, including the low-middle-income countries. This is our experience managing adult sarcomas in the tertiary cancer center of North India. MATERIALS AND METHODS: This is a retrospective analysis of the structured sarcoma database of patients treated in the surgical oncology department between 1992 and 2020...
February 21, 2024: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/38379214/management-of-a-major-varicella-zoster-exposure-in-a-pediatric-oncology-population
#22
JOURNAL ARTICLE
Carol Rossetto, Kent Sepkowitz, Jill Ackerman, Rachel Corke, Nina J Pickett, Wini Cudjoe, Janet Eagan, Mini Kamboj, Richard J O'Reilly, Farid Boulad
Management of the exposure of pediatric oncology patients to varicella zoster virus (VZV) is controversial. We report the exposure of 56 patients to a single child with chicken pox at a pediatric cancer housing facility and describe our strategic approach for their management. We reviewed the immune and clinical status of 56 children with cancer receiving ongoing treatment at Memorial Sloan Kettering Cancer Center (MSK) who, while living at a pediatric cancer housing facility, were exposed to the index patient...
February 20, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38373667/clinical-value-of-molecular-subtypes-identification-based-on-anoikis-related-lncrnas-in-castration-resistant-prostate-cancer
#23
JOURNAL ARTICLE
Kailei Chen, Yunxuan Zhang, Chengyong Li, Yuenan Liu, Qi Cao, Xiaoping Zhang
BACKGROUND: Anoikis is a distinctive type of apoptosis. It is involved in tumor progression and metastasis. But its function in castration-resistant prostate cancer remains veiled. We aimed to develop a prognostic indicator based on anoikis-related long non-coding RNAs (arlncRNAs) and to investigate their biological function in castration-resistant prostate cancer (CRPC). MATERIAL AND METHOD: Differentially expressed anoikis-related genes were extracted from two CRPC datasets, GSE51873, and GSE78201...
February 17, 2024: Cellular Signalling
https://read.qxmd.com/read/38370274/radiation-therapy-for-colorectal-liver-metastasis-the-effect-of-radiation-therapy-dose-and-chemotherapy-on-local-control-and-survival
#24
JOURNAL ARTICLE
Ishita Chen, Jeho Jeong, Paul B Romesser, Lara Hilal, John Cuaron, Melissa Zinovoy, Carla Hajj, T Jonathan Yang, Jillian Tsai, Yoshiya Yamada, Abraham J Wu, Charlie White, Megan Fiasconaro, Neil H Segal, Nancy E Kemeny, Zhigang Zhang, Christopher H Crane, Marsha Reyngold
PURPOSE: Colorectal liver metastases (CLMs) represent a radioresistant histology. We aimed to investigate CLM radiation therapy (RT) outcomes and explore the association with treatment parameters. METHODS AND MATERIALS: This retrospective analysis of CLM treated with RT at Memorial Sloan Kettering Cancer Center used Kaplan-Meier analysis to estimate freedom from local progression (FFLP), hepatic progression-free, progression-free, and overall survival (OS). Cox proportional hazards regression was used to evaluate association with clinical factors...
February 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38358761/response-to-2-induction-courses-of-bacillus-calmette-gu%C3%A3-rin-therapy-among-patients-with-high-risk-non-muscle-invasive-bladder-cancer-5-year-follow-up-of-a-phase-2-clinical-trial
#25
JOURNAL ARTICLE
Andrew B Katims, Jacob Tallman, Emily Vertosick, Shaun Porwal, Guido Dalbagni, Eugene K Cha, Robert Smith, Nicole Benfante, Harry W Herr
IMPORTANCE: With the ongoing bacillus Calmette-Guèrin (BCG) shortage, alternate therapeutic options for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) are needed. OBJECTIVE: To report the 5-year outcomes of a cohort from a prospective phase 2 trial of patients with high-risk NMIBC who underwent 12 instillations of induction BCG without maintenance. DESIGN, SETTING, AND PARTICIPANTS: Between November 2015 and June 2018, patients at Memorial Sloan Kettering Cancer Center with primary or recurrent NMIBC (high-grade Ta, T1 tumors, with or without carcinoma in situ) were prospectively enrolled to receive 2 induction courses (12 intravesical instillations) of BCG without maintenance therapy...
February 15, 2024: JAMA Oncology
https://read.qxmd.com/read/38351049/u-s-cereal-rye-winter-cover-crop-growth-database
#26
JOURNAL ARTICLE
Alexandra M Huddell, Resham Thapa, Guillermo S Marcillo, Lori J Abendroth, Victoria J Ackroyd, Shalamar D Armstrong, Gautam Asmita, Muthukumar V Bagavathiannan, Kipling S Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S Davis, Pratap Devkota, Warren A Dick, Jeffery A Evans, Wesley J Everman, Tauana Ferreira de Almeida, Michael L Flessner, Lisa M Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J Helmers, Nicholas Jordan, Thomas C Kaspar, Quirine M Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P Law, Lauren Lazaro, Ramon G Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M McVane, Jarrod O Miller, Michael J Mulvaney, Nsalambi V Nkongolo, Jason K Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S Reiter, Matt Ruark, Matthew R Ryan, Spencer Samuelson, John E Sawyer, Sarah Seehaver, Lovreet S Shergill, Yogendra Raj Upadhyaya, Mark VanGessel, Ashley L Waggoner, John M Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A Needelman, Steven B Mirsky
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States...
February 13, 2024: Scientific Data
https://read.qxmd.com/read/38349310/impact-of-rabbit-anti-thymocyte-globulin-atg-exposure-on-outcomes-after-ex-vivo-t-cell-depleted-hematopoietic-cell-transplantation-in-pediatric-and-young-adult-patients
#27
JOURNAL ARTICLE
Madhavi Lakkaraja, Audrey Mauguen, Farid Boulad, Maria I Cancio, Kevin J Curran, Andrew C Harris, Nancy A Kernan, Elizabeth Klein, Andrew L Kung, Joseph Oved, Susan Prockop, Andromachi Scaradavou, Barbara Spitzer, Richard J O'Reilly, Jaap Jan Boelens
BACKGROUND AIMS: Traditional weight-based dosing of rabbit anti-thymocyte globulin (rATG) used in allogeneic hematopoietic cell transplantation (HCT) to prevent graft-versus-host disease (GVHD) and graft rejection leads to variable exposures. High exposures induce delayed CD4+immune reconstitution (CD4+IR) and greater mortality. We sought to determine the impact of rATG exposure in children and young adults receiving various types of EX-VIVO T-cell-depleted (EX-VIVO-TCD) HCT. METHODS: Patients receiving their first EX-VIVO-TCD HCT (CliniMACS CD34+, Isolex or soybean lectin agglutination), with removal of residual T cells by E-rosette depletion (E-) between 2008 and 2018 at Memorial Sloan Kettering Cancer Center were retrospectively analyzed...
February 12, 2024: Cytotherapy
https://read.qxmd.com/read/38347332/early-onset-intrahepatic-cholangiocarcinoma-clinical-characteristics-oncological-outcomes-and-genomic-transcriptomic-features
#28
JOURNAL ARTICLE
Diamantis I Tsilimigras, Xu Han, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W Bauer, Sorin Alexandrescu, George A Poultsides, Shishir K Maithel, Hugo P Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, François Chaucy, Bas Groot Koerkamp, Itaru Endo, Kazunari Sasaki, Federico Aucejo, Xu-Feng Zhang, Hua Zhu, Timothy M Pawlik
INTRODUCTION: Data on clinical characteristics and disease-specific prognosis among patients with early onset intrahepatic cholangiocarcinoma (ICC) are currently limited. METHODS: Patients undergoing hepatectomy for ICC between 2000 and 2020 were identified by using a multi-institutional database. The association of early (≤50 years) versus typical onset (>50 years) ICC with recurrence-free (RFS) and disease-specific survival (DSS) was assessed in the multi-institutional database and validated in an external cohort...
February 12, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38342735/protocol-for-a-randomized-controlled-trial-of-brief-behavioral-activation-among-older-adult-cancer-survivors
#29
JOURNAL ARTICLE
Rebecca M Saracino, Ellen Y Park, Caraline Demirjian, Devika R Jutagir, Kelly M McConnell, Elizabeth Schofield, Patrick J Raue, Carl W Lejuez, Christian J Nelson
INTRODUCTION: As many as 35% of older adult cancer survivors (OACS; i.e., ≥65 years old) have clinically significant depression. OACS often experience fatigue, mild cognitive impairment, and increased medical comorbidities post-cancer that make them susceptible to depression. Behavioral activation (BA) is an empirically supported depression treatment in geriatric psychiatry that guides individuals to reengage in pleasurable and rewarding activities and has great potential for addressing the needs of OACS...
February 10, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38342659/a-panel-based-mutational-signature-of-mismatch-repair-deficiency-is-associated-with-durable-response-to-pembrolizumab-in-metastatic-castration-resistant-prostate-cancer
#30
JOURNAL ARTICLE
Daniel Boiarsky, Doga C Gulhan, Hunter Savignano, Gitanjali Lakshminarayanan, Heather M McClure, Rebecca Silver, Michelle S Hirsch, Lynette M Sholl, Atish D Choudhury, Guruprasad Ananda, Peter J Park, Alok K Tewari, Jacob E Berchuck
INTRODUCTION/BACKGROUND: Immune checkpoint inhibitors (ICIs) have limited efficacy in prostate cancer (PCa). Better biomarkers are needed to predict responses to ICIs. We sought to demonstrate that a panel-based mutational signature identifies mismatch repair (MMR) deficient (MMRd) PCa and is a biomarker of response to pembrolizumab. PATIENTS AND METHODS: Clinico-genomic data was obtained for 2664 patients with PCa sequenced at Dana-Farber Cancer Institute (DFCI) and Memorial Sloan Kettering (MSK)...
January 20, 2024: Clinical Genitourinary Cancer
https://read.qxmd.com/read/38337340/investigation-of-maximum-monosyllabic-word-recognition-as-a-predictor-of-speech-understanding-with-cochlear-implant
#31
JOURNAL ARTICLE
Ronja Czurda, Thomas Wesarg, Antje Aschendorff, Rainer Linus Beck, Thomas Hocke, Manuel Christoph Ketterer, Susan Arndt
Background: The cochlear implant (CI) is an established treatment option for patients with inadequate speech understanding and insufficient aided scores. Nevertheless, reliable predictive models and specific therapy goals regarding achievable speech understanding are still lacking. Method: In this retrospective study, 601 cases of CI fittings between 2005 and 2021 at the University Medical Center Freiburg were analyzed. We investigated the preoperative unaided maximum word recognition score (mWRS) as a minimum predictor for post-interventional scores at 65 dB SPL, WRS65 (CI)...
January 23, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38332462/transplantation-and-cellular-therapy-for-older-adults-the-msk-approach
#32
REVIEW
Richard J Lin, Parastoo B Dahi, Beatriz Korc-Grodzicki, Armin Shahrokni, Ann A Jakubowski, Sergio A Giralt
PURPOSE OF REVIEW: Hematologic malignances more commonly affect older individuals and often present with advanced, higher risk disease than younger patients. Allogeneic and autologous hematopoietic cell transplantation is well-established treatment modalities with curative potential following either frontline treatments for these diseases or salvage therapy in the relapsed or refractory setting. More recently, novel cellular immunotherapy such as chimeric antigen receptor T-cell therapy has been shown to lead to high response rate and durable remission in many patients with advanced blood cancers...
February 9, 2024: Current Hematologic Malignancy Reports
https://read.qxmd.com/read/38315829/changes-in-the-perioperative-management-and-outcomes-of-patients-with-upper-tract-urothelial-carcinoma-undergoing-radical-nephroureterectomy-at-memorial-sloan-kettering-cancer-center-over-20-years-of-experience
#33
JOURNAL ARTICLE
Wesley Yip, Melissa J Assel, Nathan C Wong, Andrew T Tracey, Ricardo G Alvim, Lucas Nogueira, Nima Almassi, Nirmish Singla, Timothy N Clinton, Daniel D Sjoberg, Hikmat Al-Ahmadie, A Ari Hakimi, Eugene J Pietzak, Eugene K Cha, Timothy F Donahue, Guido Dalbagni, Bernard H Bochner, Dean F Bajorin, Jonathan A Coleman
INTRODUCTION: We evaluated surgical trends, perioperative management evolution, and oncologic outcomes in patients who underwent radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) at a tertiary cancer center over a 24-year period. METHODS: Between 1995 and 2018, we evaluated 743 consecutive patients with UTUC who underwent RNU. Generalized additive models were used to estimate the associations between date of surgery and continuous outcomes using a linear model, dichotomous outcomes using a logit link, categorical outcomes using multinomial models, and 2- and 5-year survival outcomes using Cox proportional hazards models...
February 2, 2024: Urology Practice
https://read.qxmd.com/read/38315244/different-patient-versus-provider-perspectives-on-living-with-cushing-s-disease
#34
JOURNAL ARTICLE
Amanda Halstrom, I-Hsin Lin, Andrew Lin, Marc Cohen, Viviane Tabar, Eliza B Geer
CONTEXT: Patients with Cushing's disease (CD) face challenges living with and receiving appropriate care for this rare, chronic condition. Even with successful treatment, many patients experience ongoing symptoms and impaired quality of life (QoL). Different perspectives and expectations between patients and healthcare providers (HCPs) may also impair well-being. OBJECTIVE: To examine differences in perspectives on living with CD between patients and HCPs, and to compare care goals and unmet needs...
February 5, 2024: Pituitary
https://read.qxmd.com/read/38312701/a-bibliometric-and-knowledge-map-analysis-of-bispecific-antibodies-in-cancer-immunotherapy-from-2000-to-2023
#35
JOURNAL ARTICLE
Jing Wei, Huilan Zheng, Shuang Dai, Ming Liu
BACKGROUND: Bispecific antibody (BsAb)-based cancer immunotherapy has provided new avenues for the treatment of various malignancies. The approval of Blinatumomab has encouraged further investigation into these treatments, and a series of preclinical and clinical trials have been conducted, together with the publication of numerous articles. Here, the knowledge structure of BsAb-based cancer immunotherapy is summarized using bibliometric analysis to provide in-depth insight into current research trends and foci...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38308042/a-non-invasive-25-gene-plnm-score-urine-test-for-detection-of-prostate-cancer-pelvic-lymph-node-metastasis
#36
JOURNAL ARTICLE
Jinan Guo, Liangyou Gu, Heather Johnson, Di Gu, Zhenquan Lu, Binfeng Luo, Qian Yuan, Xuhui Zhang, Taolin Xia, Qingsong Zeng, Alan H B Wu, Allan Johnson, Nishtman Dizeyi, Per-Anders Abrahamsson, Heqiu Zhang, Lingwu Chen, Kefeng Xiao, Chang Zou, Jenny L Persson
BACKGROUND: Prostate cancer patients with pelvic lymph node metastasis (PLNM) have poor prognosis. Based on EAU guidelines, patients with >5% risk of PLNM by nomograms often receive pelvic lymph node dissection (PLND) during prostatectomy. However, nomograms have limited accuracy, so large numbers of false positive patients receive unnecessary surgery with potentially serious side effects. It is important to accurately identify PLNM, yet current tests, including imaging tools are inaccurate...
February 2, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38305810/global-research-trends-in-tongue-cancer-from-2000-to-2022-bibliometric-and-visualized-analysis
#37
JOURNAL ARTICLE
Beibei Wu, Tong Zhang, Ning Dai, Ding Luo, Xuejie Wang, Chen Qiao, Jian Liu
OBJECTIVES: This study conducts a systematic bibliometric analysis of tongue cancer publications to identify key topics, hotspots, and research distribution. METHODS: We analyzed tongue cancer publications in the Web of Science core collection database, assessing their quantity and quality. We investigated contributors, including countries, affiliations, journals, authors, and categories, within collaborative networks. Additionally, we synthesized key research findings using various analytical techniques, such as alluvial flow, burstness analysis, cluster analysis, co-occurrence network of associations, and network layer overlay...
February 2, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38301342/sensory-conflicts-through-short-discrete-visual-input-manipulations-identification-of-balance-responses-to-varied-input-characteristics
#38
JOURNAL ARTICLE
Jakob Ketterer, Dominic Gehring, Albert Gollhofer, Steffen Ringhof
Human balance control relies on various sensory modalities, and conflict of sensory input may result in postural instability. Virtual reality (VR) technology allows to train balance under conflicting sensory information by decoupling visual from somatosensory and vestibular systems, creating additional demands on sensory reweighting for balance control. However, there is no metric for the design of visual input manipulations that can induce persistent sensory conflicts to perturb balance. This limits the possibilities to generate sustained sensory reweighting processes and design well-defined training approaches...
January 31, 2024: Human Movement Science
https://read.qxmd.com/read/38300595/circulating-tumor-dna-posttreatment-measurements-and-clinical-correlates-in-retinoblastoma
#39
JOURNAL ARTICLE
David H Abramson, Melissa A Robbins, Y Pierre Gobin, Ira J Dunkel, Jasmine H Francis
IMPORTANCE: Plasma measurements of RB1 circulating tumor DNA (ctDNA) after completion of treatment may be associated with the development of metastases in patients with retinoblastoma. OBJECTIVE: To determine if the absence of previously detectable plasma ctDNA is associated with metastasis-free survival in patients with a minimum of 1 year follow-up after treatment of retinoblastoma. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted from June 2019 to September 2023...
February 1, 2024: JAMA Ophthalmology
https://read.qxmd.com/read/38295332/establishing-regionalized-acute-care-across-a-health-care-system-to-decentralize-postoperative-care-after-oncologic-surgery
#40
JOURNAL ARTICLE
David G Brauer, Mithat Gonen, Jeffrey A Drebin, Jeffrey S Groeger, Elizabeth L Jewell
PURPOSE: Patients undergoing oncologic surgery at major referral centers frequently experience postdischarge care fragmentation, which has been associated with poor outcomes. This report describes and evaluates the outcomes of an intervention at Memorial Sloan Kettering Cancer Center (MSKCC) to decentralize postdischarge postoperative acute care within our health care system. METHODS: In 2018, MSKCC completed the addition of six regional acute care clinics called symptom care clinics (SCCs) to existing regional outpatient clinics...
January 31, 2024: JCO oncology practice
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