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https://www.readbyqxmd.com/read/29778833/suicide-attempts-and-clinical-correlates-in-patients-with-bipolar-i-vs-ii-disorder
#1
EDITORIAL
Matteo Vismara, Benedetta Grancini, Laura Cremaschi, Lucio Oldani, Chiara Arici, Vera de Carlo, Shefali Miller, Terence A Ketter, A Carlo Altamura, Bernardo Dell'Osso
No abstract text is available yet for this article.
May 17, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29762551/a-pair-of-datasets-for-microrna-expression-profiling-to-examine-the-use-of-careful-study-design-for-assigning-arrays-to-samples
#2
Li-Xuan Qin, Huei-Chung Huang, Liliana Villafania, Magali Cavatore, Narciso Olvera, Douglas A Levine
We set out to demonstrate the logistic feasibility of careful experimental design for microarray studies and its level of scientific benefits for improving the accuracy and reproducibility of data inference. Towards this end, we conducted a study of microRNA expression using endometrioid endometrial tumours (n=96) and serous ovarian tumours (n=96) that were primary, untreated, and collected from 2000 to 2012 at Memorial Sloan Kettering Cancer Center. The same set of tumour tissue samples were profiled twice using the Agilent microRNA microarrays: once under an ideal experimental condition with balanced array-to-sample allocation and uniform handling; a second time by mimicking typical practice, with arrays assigned in the order of sample collection and processed by two technicians in multiple batches...
May 15, 2018: Scientific Data
https://www.readbyqxmd.com/read/29759259/1-300-days-and-counting-a-risk-model-approach-to-preventing-retained-foreign-objects-rfos
#3
Erika G Duggan, Jimmy Fernandez, Mary May Saulan, Dave L Mayers, Mira Nikolaj, Tamara M Strah, Lystra M Swift, Larissa Temple
BACKGROUND: A retained foreign object (RFO) is a devastating surgical complication that typically results in additional surgeries, increased length of stay, and risk of infections and is potentially fatal. Memorial Sloan Kettering Cancer Center (MSKCC) convened a multidisciplinary task force to undertake an improvement initiative to reduce the frequency of RFO incidents. METHODS: A needs assessment was undertaken using focus group interviews, review of past RFOs, and operating room (OR) observations, and a comprehensive intervention plan was initiated...
May 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29756394/prognostic-impact-of-the-pretreatment-aspartate-transaminase-alanine-transaminase-ratio-in-patients-treated-with-first-line-systemic-tyrosine-kinase-inhibitor-therapy-for-metastatic-renal-cell-carcinoma
#4
Minyong Kang, Jiwoong Yu, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Se Hoon Park, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Seong Il Seo
OBJECTIVES: To examine the prognostic role of the pretreatment aspartate transaminase/alanine transaminase or De Ritis ratio in patients with metastatic renal cell carcinoma receiving first-line systemic tyrosine kinase inhibitor therapy. METHODS: We retrospectively searched the medical records of 579 patients with metastatic renal cell carcinoma who visited Samsung Medical Center, Seoul, Korea, from January 2001 through August 2016. After excluding 210 patients, we analyzed 360 patients who received first-line tyrosine kinase inhibitor therapy...
May 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29752647/multiparametric-magnetic-resonance-imaging-versus-partin-tables-and-the-memorial-sloan-kettering-cancer-center-nomogram-in-risk-stratification-of-patients-with-prostate-cancer-referred-to-external-beam-radiation-therapy
#5
Rossano Girometti, Martina Pancot, Marco Andrea Signor, Martina Urbani, Luca Balestreri, Chiara Zuiani
PURPOSE: To evaluate the agreement between multiparametric Magnetic Resonance Imaging (mpMRI), Partin tables (PT) and the Memorial Sloan Kettering Cancer Center nomogram (MSKCCn) in assessing risk category in prostate cancer (PCa) patients referred to External Beam Radiotherapy (EBRT). MATERIALS AND METHODS: In this bicentric study, we prospectively enrolled 80 PCa patients who underwent pre-EBRT mpMRI on a 3.0T magnet with a multiparametric protocol including high-resolution, multiplanar T2-weighted sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29746527/characterization-of-a-nontypeable-haemophilus-influenzae-thermonuclease
#6
Christine Cho, Aroon T Chande, Lokesh Gakhar, Jason Hunt, Margaret R Ketterer, Michael A Apicella
Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during clinical infections. Studies in our laboratory have shown that NTHi possesses a homolog of Staphylococcus aureus thermonuclease (staphylococcal thermonuclease), NTHi nuclease (NTHi Nuc, HI_1296). This enzyme had similar size, heat stability, and divalent cation requirements to those of the staphylococcal homolog as determined by light scattering and circular dichroism spectroscopy...
2018: PloS One
https://www.readbyqxmd.com/read/29734385/growth-patterns-of-survivors-of-retinoblastoma-treated-with-ophthalmic-artery-chemosurgery
#7
Sruti S Akella, Jasmine H Francis, Andrea Knezevic, Irina Ostrovnaya, Y Pierre Gobin, Danielle Friedman, Edith Guarini, Lindsey Eibeler, Federica Catalanotti, David H Abramson
Although studies from pediatric cancers (largely acute lymphoblastic leukemia) have shown that patients undergoing systemic chemotherapy may experience decreased growth velocity during the treatment phase, no such data exist for retinoblastoma patients treated with systemic chemotherapy or ophthalmic artery chemosurgery (OAC). The purpose of this study is to report growth patterns of our retinoblastoma (Rb) population who were treated with OAC in a retrospective, single center (Memorial Sloan Kettering Cancer Center) review of 341 patients treated between 2006 and 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29727307/long-term-cognitive-and-psychological-functioning-in-post-electroconvulsive-therapy-patients
#8
Michelle L Miller, Hien Luu, Owen Gaasedelen, Amanda E Hahn-Ketter, Alexis Elmore, Naseem Dezhkam, John Bayless, David J Moser, Douglas M Whiteside
OBJECTIVE: Electroconvulsive therapy (ECT) is associated with positive outcomes for treatment-resistant mood disorders in the short term. However, there is limited research on long-term cognitive or psychological changes beyond 1 year after -ECT. This study evaluated long-term outcomes in cognitive functioning, psychiatric symptoms, and quality of life for individuals who had undergone ECT. METHODS: Eligible participants (N = 294) who completed a brief pre-ECT neuropsychological assessment within the last 14 years were recruited for a follow-up evaluation; a limited sample agreed to follow-up testing (n = 34)...
May 1, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29725898/rates-of-tp53-mutation-are-significantly-elevated-in-african-american-patients-with-gastric-cancer
#9
Elke J A H van Beek, Jonathan M Hernandez, Debra A Goldman, Jeremy L Davis, Kaitlin McLaughlin, R Taylor Ripley, Teresa S Kim, Laura H Tang, Jaclyn F Hechtman, Jian Zheng, Marinela Capanu, Nikolaus Schultz, David M Hyman, Marc Ladanyi, Michael F Berger, David B Solit, Yelena Y Janjigian, Vivian E Strong
BACKGROUND: Gastric adenocarcinoma is a heterogenous disease that results from complex interactions between environmental and genetic factors, which may contribute to the disparate outcomes observed between different patient populations. This study aimed to determine whether genomic differences exist in a diverse population of patients by evaluating tumor mutational profiles stratified by race. METHODS: All patients with gastric adenocarcinoma between 2012 and 2016 who underwent targeted next-generation sequencing of cancer genes by the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets platform were identified...
May 3, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29722827/a-broadly-conserved-nerd-genetically-interacts-with-the-exocyst-to-affect-root-growth-and-cell-expansion
#10
Rex Cole, Valera Peremyslov, Savanah Van Why, Ibrahim Moussaoui, Ann Ketter, Renee Cool, Matthew Andres Moreno, Zuzana Vejlupkova, Valerian Dolja, John E Fowler
The exocyst, a conserved, octameric protein complex helps mediate secretion at the plasma membrane, facilitating specific developmental processes that include control of root meristem size, cell elongation, and tip growth. A genetic screen for second-site enhancers in Arabidopsis identified NEW ENHANCER of ROOT DWARFISM1 (NERD1) as an exocyst interactor. Mutations in nerd1 combined with weak exocyst mutations in SEC8 and EXO70A1 result in a synergistic reduction in root growth. Alone, nerd1 alleles modestly reduce primary root growth, both by shortening the root meristem and by reducing cell elongation, but also result in a slight increase in root hair length, bulging, and rupture...
May 2, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29714663/assessment-of-bowel-and-anal-sphincter-function-after-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#11
Consuelo Rosa, Monica Di Tommaso, Luciana Caravatta, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Albina Allajbej, Marco Regoli, Isaia Al Zecca, Marta Di Nicola, Domenico Genovesi
PURPOSE: To report long-term effects on anorectal function and bowel disorders and late toxicity rate of preoperative chemoradiotherapy in patients with locally advanced rectal cancer. METHODS: Between 2000 and 2016, 201 patients treated with different neoadjuvant schedules of chemotherapy and radiotherapy doses were retrospectively analyzed. The Memorial Sloan-Kettering Cancer Center score was used for the evaluation of anal sphincter function. RESULTS: The median follow-up time was 68 months (interquartile range 35-113 months)...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29699892/primary-mutational-landscape-linked-with-pre-docetaxel-lactate-dehydrogenase-levels-predicts-docetaxel-response-in-metastatic-castrate-resistant-prostate-cancer
#12
Kenneth Hiew, Claire A Hart, Adnan Ali, Tony Elliott, Vijay Ramani, Vijay Sangar, Maurice Lau, Satish Maddineni, Mick Brown, Noel Clarke
BACKGROUND: Docetaxel chemotherapy is a standard of care for metastatic castrate-resistant prostate cancer (mCRPC): 40-50% of patients achieve a biochemical response. However, there is a lack of response predictive biomarkers. OBJECTIVE: To assess lactate dehydrogenase (LDH) as a docetaxel response biomarker in mCRPC and to examine the association of LDH with genomic alterations in primary diagnostic biopsies. DESIGN, SETTING, AND PARTICIPANTS: Clinical and associated primary tumour-targeted next-generation sequencing data from matched training (n=150) and test (n=120) cohorts of progressive mCRPC patients receiving docetaxel therapy were analysed...
April 23, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29699418/role-of-early-palliative-care-interventions-in-hematological-malignancies-and-bone-marrow-transplant-patients-barriers-and-potential-solutions
#13
Marco Ruiz, Patrick Reynolds, Regina Marranzini, Alina Khan, Jessica Ketterer, Amanda Brahim
INTRODUCTION: Despite advances in palliative care management of physical, psychological, and emotional symptoms along the spectrum of chronic conditions, early palliative care interventions are not used frequently and comprehensively in bone marrow transplant units. METHODS: The literature review of PubMed articles in English published until December 2017. RESULTS: Patients with hematologic malignancies and bone marrow transplant interventions are a heterogeneous group...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29691844/genetic-and-morphological-evaluation-game-score-for-patients-with-colorectal-liver-metastases
#14
G A Margonis, K Sasaki, S Gholami, Y Kim, N Andreatos, N Rezaee, A Deshwar, S Buettner, P J Allen, T P Kingham, T M Pawlik, J He, J L Cameron, W R Jarnagin, C L Wolfgang, M I D'Angelica, M J Weiss
BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29673946/subtyping-the-risk-of-intermediate-risk-prostate-cancer-for-active-surveillance-based-on-adverse-pathology-at-radical-prostatectomy
#15
Hiten D Patel, Mohit Gupta, Jeffrey J Tosoian, H Ballentine Carter, Alan W Partin, Jonathan I Epstein
INTRODUCTION: Intermediate-risk (IR) prostate cancer is a heterogenous classification with favorable criteria proposed based on men treated with radiation therapy but uncertain application to active surveillance. We quantified the rate of adverse surgical pathology and implications for survival for patients with favorable IR (FIR) compared to low-risk (LR) prostate cancer. MATERIALS AND METHODS: A comparative cohort study of men with prostate cancer (2009-2013) undergoing radical prostatectomy was conducted in the National Cancer Database...
April 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29672223/diagnosis-to-treatment-interval-is-an-important-clinical-factor-in-newly-diagnosed-diffuse-large-b-cell-lymphoma-and-has-implication-for-bias-in-clinical-trials
#16
Matthew J Maurer, Hervé Ghesquières, Brian K Link, Jean-Philippe Jais, Thomas M Habermann, Carrie A Thompson, Corinne Haioun, Cristine Allmer, Patrick B Johnston, Richard Delarue, Ivana N Micallef, Frederic Peyrade, David J Inwards, Nicolas Ketterer, Umar Farooq, Olivier Fitoussi, William R Macon, Thierry J Molina, Sergei Syrbu, Andrew L Feldman, Susan L Slager, George J Weiner, Stephen M Ansell, James R Cerhan, Gilles A Salles, Thomas E Witzig, Hervé Tilly, Grzegorz S Nowakowski
Purpose Selection bias in clinical trials has consequences for scientific validity and applicability of study results to the general population. There is concern that patients with clinically aggressive disease may not have enrolled in recent diffuse large B-cell lymphoma (DLBCL) trials due to the consent process and the inability to delay therapy for eligibility evaluation. We have examined the diagnosis-to-treatment interval (DTI) and its association with clinical factors and outcome in a clinic-based observational cohort of patients with DLBCL from the United States...
April 19, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29622373/antidepressants-appear-safe-in-patients-with-carcinoid-tumor-results-of-a-restrospective-review
#17
Elie Isenberg-Grzeda, Meredith MacGregor, Afton Bergel, Stacy Eagle, Fernando Espi-Forcen, Reema Mehta, Konstantina Matsoukas, Jonathan Wills, Diane Reidy-Lagunes, Yesne Alici
INTRODUCTION: Patients living with neuroendocrine tumors have high rates of depression, often necessitating antidepressants, including selective serotonin reuptake inhibitors (SSRI). Neuroendocrine tumors (NETs) secrete vasoactive substances, including serotonin, which contribute to the cluster of symptoms known as carcinoid syndrome (flushing and diarrhea). Controversy exists over whether or not antidepressants are safe in NET. We aimed to study the safety of antidepressant use in NET patients...
March 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29620693/longer-term-effectiveness-and-tolerability-of-adjunctive-open-lurasidone-in-patients-with-bipolar-disorder
#18
Shefali Miller, Dennis Do, Anda Gershon, Po W Wang, Farnaz Hooshmand, Lauren S Chang, Terence A Ketter
PURPOSE: To retrospectively assess lurasidone effectiveness/efficacy/tolerability in bipolar disorder (BD) patients. METHODS: Outpatients assessed with Systematic Treatment Enhancement Program for BD Affective Disorders Evaluation received naturalistically administered (primarily adjunctive) open lurasidone while monitored at visits with the Systematic Treatment Enhancement Program for BD Clinical Monitoring Form. RESULTS: Sixty-one patients (32 type I, 26 type II, 3 type not otherwise specified; mean ± SD age, 45...
June 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29610393/journey-from-oncologist-to-cancer-survivor-and-patient-advocate-in-the-era-of-precision-medicine
#19
Burton M Needles
In 2013, the American Association for Cancer Research (AACR) introduced the "Precision Medicine Series" of symposia. The goal of these conferences is to "highlight the incredible technology and advances in cancer research that together are enabling treatments that are precisely targeted to the unique molecular and genetic characteristics of an individual's cancer." This new series of AACR conferences reflects how patient treatment has evolved and continues to progress toward personalized treatments/medicine...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29581844/predictive-value-of-inflammation-based-prognostic-scores-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-cytoreductive-nephrectomy
#20
Hironori Fukuda, Toshio Takagi, Tsunenori Kondo, Satoru Shimizu, Kazunari Tanabe
Inflammation-based prognostic scores are useful for predicting survival in various cancers. Here, we aimed to determine the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy. We retrospectively analyzed the data of 152 patients who underwent cytoreductive nephrectomy for metastatic renal cell carcinoma between 1986 and 2015. In the multivariate stepwise analysis, the combination of age, Memorial Sloan-Kettering Cancer Center score, histology, sarcomatoid change, clinical nodal stage, brain metastasis, and liver metastasis was a significant predictor for survival (Harrell's concordance index [c-index]: 0...
March 6, 2018: Oncotarget
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