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https://www.readbyqxmd.com/read/29154919/patient-reported-outcomes-and-opioid-use-by-outpatient-cancer-patients
#1
N Moryl, V Dave, P Glare, A Bokhari, V T Malhotra, A Gulati, J Hung, V Puttanniah, Y Griffo, R Tickoo, A Wiesenthal, S D Horn, C E Inturrisi
The Memorial Sloan-Kettering Pain Registry contains patient characteristics, treatments, and outcomes for a prospective cohort of 1534 chronic pain cancer patients who were seen at outpatient pain service clinics. Average pain intensity (Brief Pain Inventory) was reported as mild by 24.6% of patients, moderate by 41.5%, and severe by 33.9%. The patient's report of average percent pain relief and health state (EQ-5D) was inversely related to average pain intensity category, while measures of pain interference, number of worst pain locations, and physical and psychological distress were directly related to pain intensity category...
November 14, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29152824/can-nomograms-predict-preoperative-axillary-lymph-node-metastasis-in-patients-with-breast-cancer-to-guide-second-look-ultrasonography
#2
Ameerah Azmil, Gaurav Jyoti Bansal
OBJECTIVES: The low sensitivity of ultrasonography (US) for diagnosing axillary lymph node metastasis in patients with breast cancer has led to the development of multiple tools in an attempt to increase preoperative sensitivity, including second-look US. We compared axillary lymph node metastasis predictor scores with postsurgical findings, using the Memorial Sloan Kettering Cancer Center (MSKCC; New York, NY) and Evidencio (www.evidencio.com) nomograms: 2 freely available online predictor tools...
November 20, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29152083/programmed-cell-death-1-expression-is-associated-with-inferior-survival-in-patients-with-primary-central-nervous-system-lymphoma
#3
Hyunsoo Cho, Se Hoon Kim, Soo-Jeong Kim, Jong Hee Chang, Woo-Ick Yang, Chang-Ok Suh, Yu Ri Kim, Ji Eun Jang, June-Won Cheong, Yoo Hong Min, Jin Seok Kim
Programmed cell death 1 (PD-1) and its ligands PD-L1/PD-L2 have been shown to mediate immune evasion in various cancers, but their prognostic implications in patients with primary central nervous system lymphoma (PCNSL) are poorly understood. Therefore, we analyzed 76 PCNSL patients at initial diagnosis who were treated homogenously with high-dose methotrexate-based chemotherapy, and evaluated the prognostic roles of high immunohistochemical PD-1, PD-L1, and PD-L2 expression. The cut-off values for high PD-1 (≥ 70 cells/high power field [HPF]), PD-L1 (≥ 100 cells/HPF), and PD-L2 (≥ 100 cells/HPF) were determined by the area under the receiver operating characteristic curve...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146616/therapeutic-potential-of-afatinib-for-cancers-with-erbb2-her2-transmembrane-domain-mutations-g660d-and-v659e
#4
Hiromasa Yamamoto, Shinichi Toyooka, Takashi Ninomiya, Shigemi Matsumoto, Masashi Kanai, Shuta Tomida, Katsuyuki Kiura, Manabu Muto, Ken Suzawa, Patrice Desmeules, Mark G Kris, Bob T Li, Marc Ladanyi
We previously reported on a family with hereditary lung cancer, in which a germline mutation in the transmembrane domain (G660D) of avian erythroblastic leukemia viral oncogene homolog 2 (erb-b2 receptor tyrosine kinase 2) (ERBB2; human epidermal growth factor receptor 2 [HER2]) seemed to be responsible for the cancer predisposition. Although few data are available on treatment, anti-ERBB2 therapeutic agents may be effective for ERBB2-mutant cancers. The familial lung cancer patient in one of the authors' institutes developed bone metastasis with enlarging lung tumors and was treated with the ERBB2 inhibitor afatinib...
November 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29145062/differentiating-multiple-vs-single-lifetime-suicide-attempters-with-bipolar-disorders-a-retrospective-study
#5
Chiara Arici, Laura Cremaschi, Cristina Dobrea, Matteo Vismara, Benedetta Grancini, Beatrice Benatti, Massimiliano Buoli, Shefali Miller, Terence A Ketter, A Carlo Altamura, Bernardo Dell'Osso
BACKGROUND: The risk of suicide in Bipolar Disorder (BD) has been estimated up to 20-30 times higher compared with the general population. Previous suicide attempts (SAs) represent a well-established risk factor for further attempts and for death by suicide in patients with psychiatric disorders. However, little is known about the socio-demographic and clinical profile of BD patients with a history of multiple SAs (MSAs). The present study sought to characterize BD patients with MSAs versus single suicide attempt (SSA) within a large Italian sample...
October 19, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29143534/decreased-activation-and-subsyndromal-manic-symptoms-predict-lower-remission-rates-in-bipolar-depression
#6
Marco Antonio Caldieraro, Samantha Walsh, Thilo Deckersbach, William V Bobo, Keming Gao, Terence A Ketter, Richard C Shelton, Noreen A Reilly-Harrington, Mauricio Tohen, Joseph R Calabrese, Michael E Thase, James H Kocsis, Louisa G Sylvia, Andrew A Nierenberg
OBJECTIVE: Activation encompasses energy and activity and is a central feature of bipolar disorder. However, the impact of activation on treatment response of bipolar depression requires further exploration. The aims of this study were to assess the association of decreased activation and sustained remission in bipolar depression and test for factors that could affect this association. METHODS: We assessed participants with Diagnostic and Statistical Manual of Mental Disorders (4th ed) bipolar depression ( n = 303) included in a comparative effectiveness study of lithium- and quetiapine-based treatments (the Bipolar CHOICE study)...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29126475/development-and-application-of-mass-spectrometric-techniques-for-ultra-trace-determination-of-236-u-in-environmental-samples-a-review
#7
REVIEW
Wenting Bu, Jian Zheng, Michael E Ketterer, Sheng Hu, Shigeo Uchida, Xiaolin Wang
Measurements of the long-lived radionuclide (236)U are an important endeavor, not only in nuclear safeguards work, but also in terms of using this emerging nuclide as a tracer in chemical oceanography, hydrology, and actinide sourcing. Depending on the properties of a sample and its neutron irradiation history, (236)U/(238)U ratios from different sources vary significantly. Therefore, this ratio can be treated as an important fingerprint for radioactive source identification, and in particular, affords a definitive means of discriminating between naturally occurring U and specific types of anthropogenic U...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29125905/arthritis-after-cancer-immunotherapy-symptom-duration-and-treatment-response
#8
Melanie H Smith, Anne R Bass
OBJECTIVE: Musculoskeletal manifestations of immune related adverse events (irAEs) after checkpoint inhibitor immunotherapy for cancer remain incompletely characterized and poorly understood. A recently published case series suggested that immunotherapy-induced arthritis is an aggressive process requiring high dose corticosteroids. METHODS: This was a retrospective chart review of all patients with musculoskeletal irAEs first seen by one of the authors between 2014 and 2016...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29124911/first-north-american-validation-and-head-to-head-comparison-of-four-preoperative-nomograms-for-prediction-of-lymph-node-invasion-before-radical-prostatectomy
#9
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Markus Graefen, Francesco Montorsi, Fred Saad, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
OBJECTIVES: To perform a head-to-head comparison of four nomograms, namely the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population. MATERIALS & METHODS: 19,775 clinically localized prostate cancer (PCa) patients underwent radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29121144/positron-emission-tomography-computed-tomography-based-assessments-of-androgen-receptor-expression-and-glycolytic-activity-as-a-prognostic-biomarker-for-metastatic-castration-resistant-prostate-cancer
#10
Josef J Fox, Somali C Gavane, Estelle Blanc-Autran, Sadek Nehmeh, Mithat Gönen, Brad Beattie, Hebert A Vargas, Heiko Schöder, John L Humm, Samson W Fine, Jason S Lewis, Stephen B Solomon, Joseph R Osborne, Darren Veach, Charles L Sawyers, Wolfgang A Weber, Howard I Scher, Michael J Morris, Steven M Larson
Importance: Androgen receptor-signaling inhibitor (ARSi) drugs prolong life in metastatic castration-resistant prostate cancer (mCRPC), but such tumors eventually become resistant and progress. Comprehensive positron emission tomography/computed tomography (PET/CT) imaging using fluoro-2-D-deoxyglucose F 18 ([18F]-FDG) for glycolysis (Glyc) and fluorodihydrotestosterone F 18 ([18F]-FDHT) for androgen receptor (AR) expression determine heterogeneity of imaging phenotypes, which may be useful in distinguishing patients who will benefit from ARSi drugs from those who need alternative treatments...
November 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29113426/activating-mutation-of-pdgfrb-gene-in-a-rare-cardiac-undifferentiated-intimal-sarcoma-of-the-left-atrium-a-case-report
#11
Xiaoling Fu, Weixin Niu, Ji Li, Amber J Kiliti, Hikmat A Al-Ahmadie, Gopa Iyer, Sizhi Paul Gao, Qi Li
Cardiac sarcoma is a rare malignant tumor with undefined genetic mutations and no targeted therapy. Here in one rare case of undifferentiated cardiac intimal sarcoma (IS), a next-generation sequencing based assay, MSK-IMPACT (Memorial Sloan Kettering - Integrated Mutation Profiling of Actionable Cancer Targets), identified a somatic, activating mutation in PDGFRB, along with amplification of PDGFRA. This E472D mutation of PDGFRB was discovered for the first time in IS. These findings suggest that concurrent aberrant PDGFRA and PDGFRB signaling may be a diagnostic biomarker and molecular therapeutic target of IS of the heart...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108268/inherent-characteristics-of-metachronous-metastatic-renal-cell-carcinoma-in-the-era-of-targeted-agents
#12
Jang Hee Han, Seung Hwan Lee, Won Sik Ham, Woong Kyu Han, Koon Ho Rha, Young Deuk Choi, Sung Joon Hong, Young Eun Yoon
Background: To assess the prognostic and predictive factors of time to treatment failure (TTF) and overall survival (OS), respectively, in patients with metachronous metastatic renal cell carcinoma (mRCC) who were treated with targeted agents. Materials and Methods: We retrospectively reviewed metachronous mRCC patients, defined as individuals diagnosed with metastatic disease >3 months after initial nephrectomy, treated at an institute since 2005. Cox proportional hazard regression analysis was performed to discover the most determinant variables associated with TTF and OS...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100452/clinical-significance-of-mskcc-nomogram-on-guiding-the-application-of-touch-imprint-cytology-and-frozen-section-in-intraoperative-assessment-of-breast-sentinel-lymph-nodes
#13
Lisha Sun, Guanglei Chen, Yizhen Zhou, Lei Zhang, Zining Jin, Weiguang Liu, Guangping Wu, Feng Jin, Kai Li, Bo Chen
The widely practiced intra-operative methods for rapid evaluation and detection of sentinel lymph node (SLN) status include frozen section (FS) and touch imprint cytology (TIC). This study optimized the use of TIC and FS in the intra-operative detection of breast SLNs based on the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Three hundred forty-two SLNs were removed from 79 patients. SLN metastatic probability was assessed by the MSKCC nomogram. The SLNs underwent intra-operative TIC and FS, as well as routine post-operative paraffin sections (RPSs)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099775/whole-blood-mrna-expression-based-prognosis-of-metastatic-renal-cell-carcinoma
#14
Karthik V Giridhar, Carlos P Sosa, David W Hillman, Cristobal Sanhueza, Candace L Dalpiaz, Brian A Costello, Fernando J Quevedo, Henry C Pitot, Roxana S Dronca, Donna Ertz, John C Cheville, Krishna Vanaja Donkena, Manish Kohli
The Memorial Sloan Kettering Cancer Center (MSKCC) prognostic score is based on clinical parameters. We analyzed whole blood mRNA expression in metastatic clear cell renal cell carcinoma (mCCRCC) patients and compared it to the MSKCC score for predicting overall survival. In a discovery set of 19 patients with mRCC, we performed whole transcriptome RNA sequencing and selected eighteen candidate genes for further evaluation based on associations with overall survival and statistical significance. In an independent validation of set of 47 patients with mCCRCC, transcript expression of the 18 candidate genes were quantified using a customized NanoString probeset...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29083243/prospective-evaluation-of-nutritional-factors-to-predict-the-risk-of-complications-for-patients-undergoing-radical-cystectomy-a-cohort-study
#15
Janie Allaire, Caroline Léger, Tal Ben-Zvi, Molière Nguilé-Makao, Yves Fradet, Louis Lacombe, Vincent Fradet
The objective of this study was to identify nutritional preoperative factors associated with complications after radical cystectomy (RC). We prospectively evaluated the Mini-Nutritional Assessment Score, body mass index (BMI), appetite, stool frequency, hydration, food intake, weight loss, albuminemia, and prealbuminemia of 144 patients who underwent RC between January 2011 and April 2014. Postoperative complications were defined as any adverse event reported in the patient's file up to 90 days after surgery...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29082376/factors-influencing-non-sentinel-node-metastasis-in-patients-with-macrometastatic-sentinel-lymph-node-involvement-and-validation-of-three-commonly-used-nomograms
#16
Hikmet Erhan Güven, Lütfi Doğan, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
OBJECTIVE: Omitting axillary lymph node dissection (ALND) in a subgroup of patients with sentinel lymph node (SLN) metastasis is becoming a widely accepted practice. Avoiding the well-known complications of ALND is the sole aim without compromising the curative intention of surgery. MATERIALS AND METHODS: The data were probed for breast cancer patients that were operated on between February 2014 and June 2016. SLN biopsies were performed in 507 patients and out of 157 patients who underwent ALND for a metastatic SLN, 151 were found eligible for the analyses as having macrometastatic (>2mm) SLN...
October 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/29066363/long-term-renal-functional-recovery-following-radical-nephrectomy-for-kidney-cancer-results-from-a-multi-center-confirmatory-study
#17
Emily C Zabor, Helena Furberg, Byron Lee, Steven Campbell, Brian R Lane, R Houston Thompson, Elvis Caraballo Antonio, Sabrina L Noyes, Harras Zaid, Edgar A Jaimes, Paul Russo
PURPOSE: To confirm the findings from a previous single-institution study of 572 patients from Memorial Sloan Kettering Cancer Center, in which we found that a significant proportion (49%) of patients recovered to their preoperative estimated glomerular filtration rate (eGFR) within 2 years following radical nephrectomy for renal cell carcinoma. MATERIALS AND METHODS: A multi-center retrospective study was conducted among 1928 patients using data contributed by three independent centers...
October 21, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29066073/factors-influencing-overall-survival-for-patients-with-metastatic-clear-cell-renal-cell-carcinoma-in-daily-practice
#18
Antoine Thiery-Vuillemin, Tiphaine Cholley, Fabien Calcagno, Marion Hugues, Tristan Maurina, Samuel Limat, Thierry Nguyen Tan Hon, Hamadi Almotlak, Guillaume Mouillet, Virginie Nerich
PURPOSE: To describe factors associated with overall survival (OS) among patients with metastatic clear-cell renal-cell carcinoma (mccRCC) in regard to evolution of systemic therapies. PATIENTS AND METHODS: Two hundred twenty-four consecutive patients with histologically confirmed mccRCC who received targeted therapy on first-line treatment between January 2007 and March 2015 were included. The primary end point was OS for metastatic first-line or second-line treatment...
September 25, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29064751/alternative-response-criteria-and-clinical-risk-factors-for-assessing-tumor-response-in-patients-with-metastatic-renal-cell-carcinoma-who-are-receiving-salvage-therapy
#19
Hyunseon C Kang, Shiva Gupta, Wei Wei, Lina Lu, Marc R Matrana, Nizar M Tannir, Haesun Choi
OBJECTIVE: The purpose of this study is to compare the prognostic value of various solid tumor response criteria as well as the additive value of clinical risk factors in patients with advanced renal cell carcinoma (RCC). MATERIALS AND METHODS: Two sets of CT scans (pretreatment scans and scans obtained 1-3.5 months after treatment) were reviewed for 57 patients with metastatic RCC treated with pazopanib in the salvage setting. Tumor response on the posttherapy scan was evaluated using Response Evaluation Criteria in Solid Tumors (RECIST) and Choi, modified Choi (mChoi), MASS (Morphology, Attenuation, Size, and Structure), and 10% threshold criteria...
December 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29062235/real-world-experience-of-everolimus-as-second-line-treatment-in-metastatic-renal-cell-cancer-after-failure-of-pazopanib
#20
Konstantinos Koutsoukos, Aristotelis Bamias, Kimon Tzannis, Marta Espinosa Montaño, Vasiliki Bozionelou, Christos Christodoulou, Dimitra Stefanou, Haralabos Kalofonos, Ignacio Duran, Konstantinos Papazisis
AIM: We aimed to provide real-life data on the outcomes of metastatic renal cell carcinoma (mRCC) patients treated with everolimus as second-line treatment after failure of first-line pazopanib. PATIENTS AND METHODS: Data from the medical charts of mRCC patients from 8 centers in Greece and Spain were reviewed. All patients had received or were continuing to receive second-line everolimus treatment after failure of first-line treatment with pazopanib. No other previous therapies were allowed...
2017: OncoTargets and Therapy
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