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https://www.readbyqxmd.com/read/28216278/outcomes-of-patients-with-metastatic-renal-cell-carcinoma-and-bone-metastases-in-the-targeted-therapy-era
#1
Sarathi Kalra, Jonathan Verma, Bradley J Atkinson, Surena F Matin, Christopher G Wood, Jose A Karam, Sue-Hwa Lin, Robert L Satcher, Pheroze Tamboli, Kanishka Sircar, Priya Rao, Paul G Corn, Nizar M Tannir, Eric Jonasch
BACKGROUND: Bone metastases (BMs) occur commonly in patients with metastatic renal cell carcinoma (mRCC). Tyrosine kinase inhibitors (TKIs) have improved the outcomes for patients with mRCC. However, data on the outcomes of mRCC patients with BMs treated with TKIs are limited. We describe the outcomes of patients with BMs treated with TKI therapy and compare them with the outcomes from a pre-TKI group. PATIENTS AND METHODS: Using an institutional tumor registry, a retrospective review of patients with mRCC from 2002 to 2003 and 2006 to 2007 was performed...
January 18, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28213730/impact-of-baseline-visceral-fat-accumulation-on-prognosis-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-systemic-therapy
#2
Ryuichi Mizuno, Akira Miyajima, Taizo Hibi, Aya Masuda, Toshiaki Shinojima, Eiji Kikuchi, Masahiro Jinzaki, Mototsugu Oya
The aim of this study was to evaluate the clinical significance of visceral fat accumulation as a prognostic factor in patients with metastatic renal cell carcinoma (mRCC) treated with systemic therapies. A total of 114 patients were retrospectively reviewed. All patients received systemic therapy for mRCC at Keio University hospital in Japan. The intra-abdominal visceral fat area was determined by computed tomography at the umbilical level. The visceral fat accumulation was defined as ≥100 cm(2). The mean visceral fat area was 107...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28205078/enoxaparin-dose-reduction-for-thrombocytopenia-in-patients-with-cancer-a-quality-assessment-study
#3
Simon Mantha, Yimei Miao, Jonathan Wills, Rekha Parameswaran, Gerald A Soff
The development of thrombocytopenia in the setting of therapeutic anticoagulation for venous thromboembolic disease (VTE) is common in cancer patients, but guidelines for management are based on limited past data and have not been validated. In 2011, Memorial Sloan Kettering Cancer Center (MSKCC) implemented the following guidelines in this setting: administer full dose enoxaparin for a platelet count > 50,000/mcL, half-dose enoxaparin for a platelet count of 25,000-50,000/mcL, and hold anticoagulation for a platelet count < 25,000/mcL...
February 16, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28188565/poor-quality-of-life-and-functioning-in-bipolar-disorder
#4
Louisa G Sylvia, Rebecca E Montana, Thilo Deckersbach, Michael E Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G McInnis, James H Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C Shelton, Susan L McElroy, Edward S Friedman, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. METHODS: Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28182305/hepatitis-b-virus-covalently-closed-circular-dna-homeostasis-is-independent-of-the-lymphotoxin-pathway-during-chronic-hbv-infection
#5
Marie-Anne Meier, Aleksei Suslov, Sylvia Ketterer, Markus H Heim, Stefan F Wieland
Current treatment options for patients with chronic hepatitis B virus (HBV) infection are not curative as they are not effective in eliminating covalently closed circular DNA (cccDNA). cccDNA is a stable template for HBV transcription in the nucleus of hepatocytes and is thought to be one of the main factors responsible for HBV persistence. Recently, activation of the lymphotoxin beta receptor (LTβR) has been shown to trigger degradation of cccDNA through induction of cytidine deaminases of the APOBEC3 family in HBV cell culture model systems...
February 9, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28170420/sustainable-production-of-housefly-musca-domestica-larvae-as-a-protein-rich-feed-ingredient-by-utilizing-cattle-manure
#6
Mahmoud Hussein, Viju V Pillai, Joshua M Goddard, Hui G Park, Kumar S Kothapalli, Deborah A Ross, Quirine M Ketterings, J Thomas Brenna, Mark B Milstein, Helene Marquis, Patricia A Johnson, Jan P Nyrop, Vimal Selvaraj
The common housefly, Musca domestica, is a considerable component of nutrient recycling in the environment. Use of housefly larvae to biodegrade manure presents an opportunity to reduce waste disposal while the rapidly assimilated insect biomass can also be used as a protein rich animal feed. In this study, we examine the biodegradation of dairy cattle manure using housefly larvae, and the nutritional value of the resulting larva meal as a feed ingredient. Our results demonstrated that dairy cattle manure presents a balanced substrate for larval growth, and the spent manure showed reductions in concentration of total nitrogen (24...
2017: PloS One
https://www.readbyqxmd.com/read/28169111/expression-pattern-of-immune-checkpoint-associated-molecules-in-radical-nephrectomy-specimens-as-a-prognosticator-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-tyrosine-kinase-inhibitors
#7
Takuto Hara, Hideaki Miyake, Masato Fujisawa
OBJECTIVE: To analyze the expression pattern of immune checkpoint-associated molecules in tumor tissues to determine the prognostic significance of these molecules in patients with metastatic renal cell carcinoma (mRCC) treated with tyrosine kinase inhibitors (TKIs). METHODS: Radical nephrectomy specimens were obtained from 62 patients treated with TKIs as first-line systemic therapy for mRCC. The proportions of programmed death-1 (PD-1)-positive tumor infiltrating lymphocytes (TILs) as well as those of tumor cells positive for PD-ligand 1 (PD-L1) and PD-L2 were analyzed by immunohistochemical staining...
February 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28161983/prospective-correlates-of-early-30%C3%A2-day-readmissions-on-a-cardiothoracic-surgery-service
#8
Mark W Ketterer, Mansi Chawa, Gaetano Paone
Known to vary widely among hospitals for unclear reasons, early readmissions are associated with higher mortality and are suspected to frequently be due to inadequate discharge preparation/planning. It has been previously documented that the strongest and most consistent predictor of early readmissions in CHF patients is chronic cognitive impairment, and compensatory assistance with adherence on discharge improves early readmission rates. Prospective observational study. The present investigation examined multiple putative perioperative predictors of early readmission in a hospitalized Cardiothoracic Surgery Service...
February 6, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28159866/aspirin-is-associated-with-improved-survival-in-severely-thrombocytopenic-cancer-patients-with-acute-myocardial-infarction
#9
Attila Feher, Polydoros N Kampaktsis, Rekha Parameswaran, Eytan M Stein, Richard Steingart, Dipti Gupta
BACKGROUND: Patients with hematologic malignancies are at risk for severe thrombocytopenia (sTP). The risk and benefit of aspirin are not known in thrombocytopenic cancer patients experiencing acute myocardial infarction (AMI). MATERIALS AND METHODS: Medical records of patients with hematologic malignancies diagnosed with AMI at Memorial Sloan Kettering Cancer Center during 2005-2014 were reviewed. sTP was defined as a platelet count <50,000 cells per µL within 7 days of AMI...
February 3, 2017: Oncologist
https://www.readbyqxmd.com/read/28156614/effect-of-discharge-to-subacute-rehabilitation-sar-on-hospitalized-patients-with-progressive-gastrointestinal-gi-cancer
#10
Anjali V Desai, Leonard Saltz
: 41 Background: SAR may be an alternative when hospice is declined. However, the outcomes of discharges to SAR in cancer patients with progressive (chemotherapy-refractory) disease are not known. We examined the characteristics and outcomes of patients with debility from progressive metastatic GI cancer who were discharged to SAR after an admission to our center. METHODS: An institutional electronic database was queried to identify patients of the GI medical oncology service of Memorial Sloan Kettering Cancer Center who had been discharged to a SAR facility...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152937/elective-chemotherapy-admissions-an-opportunity-to-improve-wait-times
#11
Mary E Dowling
: 240 Background: Chemotherapy wait times are a well-recognized challenge facing cancer hospitals. Recent publications have stated that not only do wait times affect patients but they increase costs and consume hospital resources. Wait times lead to longer lengths of stay and require additional staff attention. Reducing chemotherapy treatment wait times has long been a priority of Sloan Kettering, with this study focusing on inpatient chemo processes. During October and November of 2014, 6 current state observations were performed in chemo nursing verification, chemo pharmacy and an inpatient chemo unit...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152230/complementary-role-of-the-memorial-sloan-kettering-cancer-center-nomogram-to-the-american-joint-committee-on-cancer-system-for-the-prediction-of-relapse-of-major-salivary-gland-carcinoma-after-surgery
#12
Wen-Chi Chou, Kai-Ping Chang, Chang-Hsien Lu, Miao-Fen Chen, Yu-Fan Cheng, Kun-Yun Yeh, Cheng-Hsu Wang, Yung-Chang Lin, Ta-Sen Yeh
BACKGROUND: The purpose of this study was to test the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram in predicting recurrence risk of major salivary gland carcinoma in an Asian cohort. METHODS: We retrospectively enrolled 149 patients who had undergone intended curative resections for major salivary gland carcinoma between 2007 and 2012. The performance of the MSKCC nomogram and the American Joint Committee on Cancer (AJCC) seventh staging system in predicting recurrence risk was compared...
February 2, 2017: Head & Neck
https://www.readbyqxmd.com/read/28138524/uncovering-the-forces-between-nucleosomes-using-dna-origami
#13
Jonas J Funke, Philip Ketterer, Corinna Lieleg, Sarah Schunter, Philipp Korber, Hendrik Dietz
Revealing the energy landscape for nucleosome association may contribute to the understanding of higher-order chromatin structures and their impact on genome regulation. We accomplish this in a direct measurement by integrating two nucleosomes into a DNA origami-based force spectrometer, which enabled subnanometer-resolution measurements of nucleosome-nucleosome distance frequencies via single-particle electron microscopy imaging. From the data, we derived the Boltzmann-weighted distance-dependent energy landscape for nucleosome pair interactions...
November 2016: Science Advances
https://www.readbyqxmd.com/read/28135023/nonsteroidal-anti-inflammatory-drugs-nsaids-and-paracetamol-do-not-affect-6-month-mood-stabilizing-treatment-outcome-among-482-patients-with-bipolar-disorder
#14
Ole Köhler-Forsberg, Louisa Sylvia, Michael Thase, Joseph R Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L Bowden, Melvin McInnis, James H Kocsis, Edward S Friedman, Terence A Ketter, Susan McElroy, Richard C Shelton, Andrew A Nierenberg
BACKGROUND: Many mood disorder patients need analgesics due to increased pain sensitivity. Recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit antidepressant treatment, which requires replication before clinical recommendations. METHODS: The Clinical and Health Outcomes Initiatives in Comparative Effectiveness for Bipolar Disorder Study randomized participants to 6 months lithium or quetiapine treatment. Use of NSAIDs and paracetamol was assessed throughout the study period and psychopathology measured with the Clinical Global Impression Scale for Bipolar Disorder (CGI-BP) and Bipolar Inventory of Symptoms Scale (BISS)...
January 30, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28124589/long-term-extensions-of-randomized-vaccination-trials-of-acc-001-and-qs-21-in-mild-to-moderate-alzheimer-s-disease
#15
Michael Hüll, Carl Sadowsky, Heii Arai, Ghislaine Le Prince Leterme, Ann Holstein, Kevin Booth, Yahong Peng, Tamotsu Yoshiyama, Hideo Suzuki, Nzeera Ketter, Enchi Liu, J Michael Ryan
OBJECTIVES: Long-term safety and tolerability of ACC-001 (vanutide cridificar), an anti-amyloid-beta therapeutic vaccine, was evaluated in subjects with mild to moderate Alzheimer's disease. DESIGN: Phase 2a extension studies of randomized parent trials were conducted in the United States, European Union, and Japan. METHODS: Four immunizations of ACC-001 were administered at the same 3 dose levels (3, 10, and 30 µg) to subjects randomized in the parent studies; ACC-001 was administered with QS-21 adjuvant...
January 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28124233/american-tertiary-clinic-referred-bipolar-ii-disorder-versus-bipolar-i-disorder-associated-with-hastened-depressive-recurrence
#16
Bernardo Dell'Osso, Saloni Shah, Dennis Do, Laura D Yuen, Farnaz Hooshmand, Po W Wang, Shefali Miller, Terence A Ketter
BACKGROUND: Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD type II (BD II) versus type I (BD I) in relation to time to depressive recurrence and recovery from major depressive episode. We therefore assessed times to depressive recurrence/recovery in tertiary clinic-referred BD II versus I patients. METHODS: Outpatients referred to Stanford BD Clinic during 2000-2011 were assessed with Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and with Clinical Monitoring Form during up to 2 years of naturalistic treatment...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28116011/supplemental-milestones-for-emergency-medicine-residency-programs-a-validation-study
#17
Andrew R Ketterer, David H Salzman, Jeremy B Branzetti, Michael A Gisondi
INTRODUCTION: Emergency medicine (EM) residency programs may be 36 or 48 months in length. The Residency Review Committee for EM requires that 48-month programs provide educational justification for the additional 12 months. We developed additional milestones that EM training programs might use to assess outcomes in domains that meet this accreditation requirement. This study aims to assess for content validity of these supplemental milestones using a similar methodology to that of the original EM Milestones validation study...
January 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28111046/validation-and-comparison-between-current-prognostication-systems-for-pancreatic-neuroendocrine-neoplasms-a%C3%A2-single-institution-experience-with-176-patients
#18
Roxanne Teo, Brian K P Goh, David W M Tai, John C Allen, Tony K H Lim, Jacqueline S G Hwang, Damien M Tan, Ser-Yee Lee, Chung-Yip Chan, Peng-Chung Cheow, Pierce K H Chow, London L P J Ooi, Alexander Y F Chung, Simon Ong
BACKGROUND: This article aims to validate and compare the performance of 6 prognostication systems-the World Health Organization 2010 grading criteria, the European Neuroendocrine Tumour Society and the American Joint Committee for Cancer staging systems, the Memorial Sloan Kettering Cancer Center staging and grading systems, as well as the Bilimoria criteria in a cohort of patients with pancreatic neuroendocrine neoplasms at a single institution. METHODS: A retrospective review of 176 patients with histologically proven pancreatic neuroendocrine neoplasm was performed...
January 19, 2017: Surgery
https://www.readbyqxmd.com/read/28108284/first-line-pazopanib-in-non-clear-cell-renal-carcinoma-the-italian-retrospective-multicenter-panorama-study
#19
Sebastiano Buti, Melissa Bersanelli, Francesca Maines, Gaetano Facchini, Francesco Gelsomino, Fable Zustovich, Matteo Santoni, Elena Verri, Ugo De Giorgi, Cristina Masini, Franco Morelli, Maria Giuseppa Vitale, Teodoro Sava, Giuseppe Prati, Carmelinda Librici, Anna Paola Fraccon, Giuseppe Fornarini, Marco Maruzzo, Francesco Leonardi, Orazio Caffo
INTRODUCTION: Pazopanib is a standard first-line treatment for metastatic clear-cell renal cell carcinoma (ccRCC). Very few data on its activity in non-clear-cell renal cell carcinoma (nccRCC) are currently available. The aim of this study was to retrospectively analyze efficacy and toxicity of pazopanib in nccRCC patients. PATIENTS AND METHODS: Records from advanced nccRCC patients (consecutive sample) treated with first-line pazopanib between 2010 and 2015 at 17 Italian centers were reviewed...
December 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28104336/indicators-of-cognitive-impairment-from-a-medical-record-review-correlations-with-early-30-d-readmissions-among-hospitalized-patients-in-a-nephrology-unit
#20
Matthew J Jasinski, Mark A Lumley, Sandeep Soman, Jerry Yee, Mark W Ketterer
BACKGROUND: Patients with end-stage renal disease have the highest 30-day hospital readmission rates of any medical condition. Previous research suggests that cognitive impairment contributes to readmission. It is important to identify patients at risk for early readmission, and this might be accomplished efficiently using medical record data. METHOD: We reviewed the medical records of 100 patients with kidney disease (57 women, mean age = 61.2) who were hospitalized in the nephrology unit at an urban U...
October 19, 2016: Psychosomatics
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