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https://www.readbyqxmd.com/read/28921573/contralateral-breast-cancers-independent-cancers-or-metastases
#1
Colin B Begg, Irina Ostrovnaya, Felipe C Geyer, Anastasios D Papanastasiou, Charlotte Ky Ng, Rita Sakr, Jonine L Bernstein, Kathleen A Burke, Tari A King, Salvatore Piscuoglio, Audrey Mauguen, Irene Orlow, Britta Weigelt, Venkatraman E Seshan, Monica Morrow, Jorge S Reis-Filho
A cancer in the contralateral breast in a woman with a previous or synchronous breast cancer is typically considered to be an independent primary tumor. Emerging evidence suggests that in a small subset of these cases the second tumor represents a metastasis. We sought to investigate the issue using massively parallel sequencing targeting 254 genes recurrently mutated in breast cancer. We examined the tumor archives at Memorial Sloan Kettering Cancer Center for the period 1995-2006 to identify cases of contralateral breast cancer where surgery for both tumors was performed at the Center...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28919181/lymphadenectomy-in-gleason-7-prostate-cancer-adherence-to-guidelines-and-effect-on-clinical-outcomes
#2
Thenappan Chandrasekar, Hanan Goldberg, Zachary Klaassen, Rashid K Sayyid, Robert J Hamilton, Neil E Fleshner, Girish S Kulkarni
BACKGROUND: To examine usage trends, guideline adherence, and survival data for patients undergoing lymphadenectomy (LND) at the time of radical prostatectomy (RP) for Gleason 7 prostate cancer (PCa). METHODS: The SEER database was queried for all patients with nonmetastatic biopsy Gleason 7 PCa from 2004 to 2013. Distribution and trends of LND were analyzed. The Memorial-Sloan Kettering Cancer Center nomogram was applied to stratify patients based on risk of nodal disease at time of RP (<5% risk or ≥5% risk)...
September 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28918175/characterization-of-patients-with-poor-risk-metastatic-renal-cell-carcinoma-results-from-a%C3%A2-pooled-clinical-trials-database
#3
Lana Hamieh, Rana R McKay, Xun Lin, Ronit Simantov, Toni K Choueiri
BACKGROUND: Poor-risk patients with metastatic renal-cell carcinoma remain poorly characterized in prospective clinical trials. Therefore, we sought to provide a comprehensive analysis of this patient population, defined by 3 widely used prognostic models, treated with targeted therapy. PATIENTS AND METHODS: We conducted a pooled retrospective analysis of 4736 metastatic renal-cell carcinoma patients treated on phase 2 and 3 clinical trials. Poor-risk patients were defined according to the Memorial Sloan Kettering Cancer Center (MSKCC), International Metastatic Renal Cell Carcinoma Database Consortium (IMDC), and Hudes risk models...
August 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28881294/sleep-disturbance-may-impact-treatment-outcome-in-bipolar-disorder-a-preliminary-investigation-in-the-context-of-a-large-comparative-effectiveness-trial
#4
Louisa G Sylvia, Weilynn C Chang, Masoud Kamali, Mauricio Tohen, Gustavo Kinrys, Thilo Deckersbach, Joseph R Calabrese, Michael E Thase, Noreen Reilly-Harrington, William V Bobo, James H Kocsis, Melvin G McInnis, Charles L Bowden, Terence A Ketter, Edward S Friedman, Richard C Shelton, Susan L McElroy, Keming Gao, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: Bipolar patients experience sleep disturbances during and between mood episodes. Yet the impact of sleep on treatment with different medications has not been fully explored. The purpose of this paper is to explore the potential impact of poor sleep at baseline on outcomes in a randomized effectiveness trial of quetiapine and lithium. METHODS: The Bipolar CHOICE study was a 6-month, parallel group, multisite randomized controlled trial. Participants with bipolar disorder (N = 482; 59% female and age 18-70 years) received quetiapine or lithium...
August 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28873162/mutation-detection-in-patients-with-advanced-cancer-by-universal-sequencing-of-cancer-related-genes-in-tumor-and-normal-dna-vs-guideline-based-germline-testing
#5
Diana Mandelker, Liying Zhang, Yelena Kemel, Zsofia K Stadler, Vijai Joseph, Ahmet Zehir, Nisha Pradhan, Angela Arnold, Michael F Walsh, Yirong Li, Anoop R Balakrishnan, Aijazuddin Syed, Meera Prasad, Khedoudja Nafa, Maria I Carlo, Karen A Cadoo, Meg Sheehan, Megan H Fleischut, Erin Salo-Mullen, Magan Trottier, Steven M Lipkin, Anne Lincoln, Semanti Mukherjee, Vignesh Ravichandran, Roy Cambria, Jesse Galle, Wassim Abida, Marcia E Arcila, Ryma Benayed, Ronak Shah, Kenneth Yu, Dean F Bajorin, Jonathan A Coleman, Steven D Leach, Maeve A Lowery, Julio Garcia-Aguilar, Philip W Kantoff, Charles L Sawyers, Maura N Dickler, Leonard Saltz, Robert J Motzer, Eileen M O'Reilly, Howard I Scher, Jose Baselga, David S Klimstra, David B Solit, David M Hyman, Michael F Berger, Marc Ladanyi, Mark E Robson, Kenneth Offit
Importance: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention. Objective: To determine the proportion and potential clinical implications of inherited variants detected using simultaneous sequencing of the tumor and normal tissue ("tumor-normal sequencing") compared with genetic test results based on current guidelines. Design, Setting, and Participants: From January 2014 until May 2016 at Memorial Sloan Kettering Cancer Center, 10 336 patients consented to tumor DNA sequencing...
September 5, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28843918/the-safety-and-tolerability-of-cariprazine-in-patients-with-manic-or-mixed-episodes-associated-with-bipolar-i-disorder-a-16-week-open-label-study
#6
Terence A Ketter, Gary S Sachs, Suresh Durgam, Kaifeng Lu, Anju Starace, István Laszlovszky, György Németh
BACKGROUND: We evaluated the safety/tolerability of longer-term open-label treatment with cariprazine in patients who had responded to cariprazine for acute bipolar mania. METHODS: In this multinational, multicenter study, open-label, flexible-dose, cariprazine 3-12mg/d was administered for up to 16 weeks to patients (18-65 years) with bipolar mania. Safety evaluations included adverse events (AEs), laboratory values, vital signs, and extrapyramidal symptom (EPS) scales...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28843917/subjective-versus-objective-evening-chronotypes-in-bipolar-disorder
#7
Anda Gershon, Christopher N Kaufmann, Colin A Depp, Shefali Miller, Dennis Do, Jamie M Zeitzer, Terence A Ketter
BACKGROUND: Disturbed sleep timing is common in bipolar disorder (BD). However, most research is based upon self-reports. We examined relationships between subjective versus objective assessments of sleep timing in BD patients versus controls. METHODS: We studied 61 individuals with bipolar I or II disorder and 61 healthy controls. Structured clinical interviews assessed psychiatric diagnoses, and clinician-administered scales assessed current mood symptom severity...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28835295/confirmatory-factor-analysis-of-the-beck-depression-inventory-ii-in-patients-with-advanced-cancer-a-theory-driven-approach
#8
Kristen G Tobias, Jonathan Lehrfeld, Barry Rosenfeld, Hayley Pessin, William Breitbart
OBJECTIVE: The diagnosis and treatment of depression are complicated by the presence of a serious medical illness, such as cancer. The role of inflammation in the pathophysiology of depression remains unknown; however, the symptom cluster of sickness behavior is more clearly related to inflammation. Symptom clusters may provide the specificity needed to improve treatment outcomes. The purpose of this study is to use confirmatory factor analysis to examine the construct of sickness behavior in patients with advanced cancer using the Beck Depression Inventory-II (BDI-II)...
August 24, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28826887/corrigendum-to-bipolar-mixed-features-results-from-the-comparative-effectiveness-for-bipolar-disorder-bipolar-choice-study-journal-of-affective-disorders-217-2017-183-189
#9
Mauricio Tohen, Alexandra K Gold, Louisa G Sylvia, Rebecca E Montana, Susan L McElroy, Michael E Thase, Dustin J Rabideau, Andrew A Nierenberg, Noreen A Reilly-Harrington, Edward S Friedman, Richard C Shelton, Charles L Bowden, Vivek Singh, Thilo Deckersbach, Terence A Ketter, Joseph R Calabrese, William V Bobo, Melvin G McInnis
No abstract text is available yet for this article.
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28798822/an-assessment-of-prostate-cancer-research-international-active-surveillance-prias-criteria-for-active-surveillance-of-clinically-low-risk-prostate-cancer-patients
#10
Vitor da Silva, Ilias Cagiannos, Luke T Lavallée, Ranjeeta Mallick, Kelsey Witiuk, Sonya Cnossen, James A Eastham, Dean A Fergusson, Chris Morash, Rodney H Breau
INTRODUCTION: Active surveillance is a strategy to delay or prevent treatment of indolent prostate cancer. The Prostate Cancer Research International: Active Surveillance (PRIAS) criteria were developed to select patients for prostate cancer active surveillance. The objective of this study was to compare pathological findings from PRIAS-eligible and PRIAS-ineligible clinically low-risk prostate cancer patients. METHODS: A D'Amico low-risk cohort of 1512 radical prostatectomy patients treated at The Ottawa Hospital or Memorial Sloan Kettering Cancer Centre between January 1995 and December 2007 was reviewed...
August 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28781819/progression-free-survival-of-first-line-treatment-with-molecular-targeted-therapy-may-be-a-meaningful-intermediate-endpoint-for-overall-survival-in-patients-with-metastatic-renal-cell-carcinoma
#11
Nobuki Furubayashi, Takahito Negishi, Takuya Yamashita, Shuhei Kusano, Kenichi Taguchi, Mototsugu Shimokawa, Motonobu Nakamura
The aim of the present study was to investigate the association between clinical parameters and the overall survival (OS) of Japanese patients with metastatic renal cell carcinoma (mRCC). The medical records of 59 consecutive mRCC patients receiving molecular-targeted therapy were retrospectively assessed. Kaplan-Meier and log-rank analyses were used to evaluate the progression-free survival (PFS) and OS, and a multivariate Cox proportional hazard model was used to analyze the clinical parameters for their prognostic relevance...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28780722/validation-and-head-to-head-comparison-of-three-nomograms-predicting-probability-of-lymph-node-invasion-of-prostate-cancer-in-patients-undergoing-extended-and-or-sentinel-lymph-node-dissection
#12
Nikolaos Grivas, Esther Wit, Corinne Tillier, Erik van Muilekom, Floris Pos, Alexander Winter, Henk van der Poel
PURPOSE: The updated Winter nomogram is the only nomogram predicting lymph node invasion (LNI) in prostate cancer (PCa) patients based on sentinel node (SN) dissection (sLND). The aim of the study was to externally validate the Winter nomogram and examine its performance in patients undergoing extended pelvic lymph node dissection (ePLND), ePLND combined with SN biopsy (SNB) and sLND only. The results were compared with the Memorial Sloan Kettering Cancer Center (MSKCC) and updated Briganti nomograms...
August 5, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28760025/commentary-on-the-risk-of-treatment-emergent-mania-with-methylphenidate-in-bipolar-disorder
#13
Terence A Ketter, Bernardo Dell'Osso
No abstract text is available yet for this article.
August 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28760021/calling-for-more-research-of-medication-effects-in-bipolar-disorder-response-to-ketter-and-dell-osso
#14
Mikael Landén, Alexander Viktorin
No abstract text is available yet for this article.
August 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28755622/trajectories-of-suicidal-ideation-over-6-months-among-482-outpatients-with-bipolar-disorder
#15
Ole Köhler-Forsberg, Trine Madsen, Ida Behrendt-Møller, Louisa Sylvia, Charles L Bowden, Keming Gao, William V Bobo, Madhukar H Trivedi, Joseph R Calabrese, Michael Thase, Richard C Shelton, Melvin McInnis, Mauricio Tohen, Terence A Ketter, Edward S Friedman, Thilo Deckersbach, Susan L McElroy, Noreen A Reilly-Harrington, Andrew A Nierenberg
INTRODUCTION: Suicidal ideation occurs frequently among individuals with bipolar disorder; however, its course and persistence over time remains unclear. We aimed to investigate 6-months trajectories of suicidal ideation among adults with bipolar disorder. METHODS: The Bipolar CHOICE study randomized 482 outpatients with bipolar disorder to 6 months of lithium- or quetiapine-based treatment including other psychotropic medications as clinically indicated. Participants were asked at 9 visits about suicidal ideation using the Concise Health Risk Tracking scale...
July 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28747519/the-impact-of-adding-sentinel-node-biopsy-to-extended-pelvic-lymph-node-dissection-on-the-biochemical-recurrence-of-prostate-cancer-patients-treated-with-robot-assisted-radical-prostatectomy
#16
Nikolaos Grivas, Esther Wit, Teele Kuusk, Gijs KleinJan, Maarten Donswijk, Fijs van Leeuwen, Henk van der Poel
The benefit of adding sentinel node biopsy (SNB) to extended pelvic lymph node dissection (ePLND), remains controversial. Aim of our study was to evaluate biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP) and ePLND in prostate cancer (PCa) patients, stratified by the application of SNB. The results were compared with the predictions of the updated Memorial Sloan Kettering Cancer Center (MSKCC) nomogram. Methods: Between January 2006 and November 2016, 920 patients underwent RARP with ePLND combined with or without SNB (184 and 736 patients, respectively)...
July 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28723377/external-validation-of-the-mskcc-and-imdc-risk-models-in-patients-treated-with-targeted-therapy-as-a-first-line-and-subsequent-second-line-treatment-a-japanese-multi-institutional-study
#17
Nobuyuki Tanaka, Ryuichi Mizuno, Keiichi Ito, Suguru Shirotake, Yota Yasumizu, Ayako Masunaga, Yujiro Ito, Yasumasa Miyazaki, Masayuki Hagiwara, Kent Kanao, Shuji Mikami, Ken Nakagawa, Tetsuo Momma, Takeshi Masuda, Tomohiko Asano, Masafumi Oyama, Mototsugu Oya
BACKGROUND: Two risk models, the Memorial Sloan Kettering Cancer Center (MSKCC) model and the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) model, have been studied in metastatic renal cell carcinoma (mRCC) treated with targeted therapy. OBJECTIVE: To validate externally the predictive accuracies of the MSKCC and IMDC models for prognosis in mRCC patients treated with first-line and subsequent second-line targeted therapy. DESIGN, SETTING, AND PARTICIPANTS: A total of 311 patients were assessed retrospectively...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28714559/how-we-make-dna-origami
#18
Klaus F Wagenbauer, Floris A S Engelhardt, Evi K Stahl, Vera K Hechtl, Pierre Stömmer, Fabian Seebacher, Letizia Meregalli, Philip Ketterer, Thomas Gerling, Hendrik Dietz
DNA ORIGAMI has attracted substantial attention since its invention ten years ago due to the seemingly infinite possibilities that it affords for creating customized nanoscale objects. While the basic concept of DNA origami is easy to understand, using custom DNA origami in practical applications requires detailed know-how for designing and producing the particles with sufficient quality, and preparing them at appropriate concentrations with the necessary degree of purity in custom environments. Such know-how is not readily available for newcomers to the field, thus slowing down the rate at which new applications outside the field of DNA nanotechnology may emerge...
July 17, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28706589/catheter-ablation-of-atrial-fibrillation-facilitated-by-preprocedural-three-dimensional-transesophageal-echocardiography-long-term-outcome
#19
Klaus Kettering, Felix Gramley, Stephan von Bardeleben
AIM: To evaluate the long-term outcome of catheter ablation of atrial fibrillation (AF) facilitated by preprocedural three-dimensional (3-D) transesophageal echocardiography. METHODS: In 50 patients, 3D transesophageal echocardiography (3D TEE) was performed immediately prior to an ablation procedure (paroxysmal AF: 30 patients, persistent AF: 20 patients). The images were available throughout the ablation procedure. Two different ablation strategies were used. In most of the patients with paroxysmal AF, the cryoablation technique was used (Arctic Front Balloon, CryoCath Technologies/Medtronic; group A2)...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28695373/catheter-ablation-of-persistent-atrial-fibrillation-circumferential-pulmonary-vein-ablation-beneficial-effect-of-an-additional-linear-lesion-at-the-roof-of-the-left-atrium-on-the-long-term-outcome
#20
Klaus Kettering, Dag-Hau Yim, Felix Gramley
BACKGROUND: Circumferential pulmonary vein ablation is still the standard approach in patients with persistent atrial fibrillation. However, the results are not very favourable and more complex ablation strategies are the subject of current controversy. Therefore, we have evaluated the effect of an additional linear lesion at the roof of the left atrium on the long-term outcome. METHODS: A total of 125 patients with symptomatic persistent atrial fibrillation underwent a circumferential pulmonary vein ablation procedure in combination with an additional linear lesion at the roof of the left atrium (group A)...
July 10, 2017: Herzschrittmachertherapie & Elektrophysiologie
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