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https://www.readbyqxmd.com/read/27932423/integrated-genomic-analysis-of-survival-outliers-in-glioblastoma
#1
Sen Peng, Harshil Dhurv, Brock Armstrong, Bodour Salhia, Christophe Legendre, Jeffrey Kiefer, Julianna Parks, Selene Virk, Andrew E Sloan, Quinn T Ostrom, Jill S Barnholtz-Sloan, Nhan L Tran, Michael E Berens
BACKGROUND: To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent radiation and temozolomide); "GB outliers" were identified: long-term survivor of 33 months (LTS; n = 8) versus short-term survivor of 7 months (STS; n = 10). METHODS: We implemented exome, RNA, whole genome sequencing, and DNA methylation for collection of deep genomic data from STS and LTS GB patients...
December 8, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27929494/the-dosimetric-impact-of-control-point-spacing-for-sliding-gap-mlc-fields
#2
Benjamin J Zwan, Jonathan Hindmarsh, Erin Seymour, Kankean Kandasamy, Kirbie Sloan, Rajesakar David, Christopher Lee
Dynamic sliding gap multileaf collimator (MLC) fields are used to model MLC properties within the treatment planning system (TPS) for dynamic treatments. One of the key MLC properties in the Eclipse TPS is the dosimetric leaf gap (DLG) and precise determination of this parameter is paramount to ensuring accurate dose delivery. In this investigation, we report on how the spacing between control points (CPs) for sliding gap fields impacts the dose delivery, MLC positioning accuracy, and measurement of the DLG...
November 8, 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27927265/trends-and-risk-factors-for-human-q-fever-in-australia-1991-2014
#3
T S Sloan-Gardner, P D Massey, P Hutchinson, K Knope, E Fearnley
Australian abattoir workers, farmers, veterinarians and people handling animal birthing products or slaughtering animals continue to be at high risk of Q fever despite an effective vaccine being available. National Notifiable Diseases Surveillance System data were analysed for the period 1991-2014, along with enhanced risk factor data from notified cases in the states of New South Wales and Queensland, to examine changes in the epidemiology of Q fever in Australia. The national Q fever notification rate reduced by 20% [incident rate ratio (IRR) 0·82] following the end of the National Q fever Management Program in 2006, and has increased since 2009 (IRR 1·01-1·34)...
December 8, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27923907/deubiquitinase-usp13-maintains-glioblastoma-stem-cells-by-antagonizing-fbxl14-mediated-myc-ubiquitination
#4
Xiaoguang Fang, Wenchao Zhou, Qiulian Wu, Zhi Huang, Yu Shi, Kailin Yang, Cong Chen, Qi Xie, Stephen C Mack, Xiuxing Wang, Angel M Carcaboso, Andrew E Sloan, Gaoliang Ouyang, Roger E McLendon, Xiu-Wu Bian, Jeremy N Rich, Shideng Bao
Glioblastoma is the most lethal brain tumor and harbors glioma stem cells (GSCs) with potent tumorigenic capacity. The function of GSCs in tumor propagation is maintained by several core transcriptional regulators including c-Myc. c-Myc protein is tightly regulated by posttranslational modification. However, the posttranslational regulatory mechanisms for c-Myc in GSCs have not been defined. In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential...
December 6, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27923485/randomized-multicenter-trial-comparing-sternotomy-closure-with-rigid-plate-fixation-to-wire-cerclage
#5
Keith B Allen, Vinod H Thourani, Yoshifumi Naka, Kendra J Grubb, John Grehan, Nirav Patel, T Sloane Guy, Kevin Landolfo, Marc Gerdisch, Mark Bonnell, David J Cohen
OBJECTIVE: To evaluate sternal healing, complications, and costs after sternotomy closure with rigid plate fixation or wire cerclage. METHODS: This prospective, single-blinded, multicenter trial randomized 236 patients at 12 US centers at the time of sternal closure to either rigid plate fixation (n = 116) or wire cerclage (n = 120). The primary endpoint, sternal healing at 6 months, was evaluated by a core laboratory using computed tomography and a 6-point scale (greater scores represent greater healing)...
November 17, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27921276/relationship-between-physician-adjudicated-adverse-events-and-patient-reported-health-related-quality-of-life-in-a-phase-ii-clinical-trial-nct01143402-of-patients-with-metastatic-uveal-melanoma
#6
Thomas M Atkinson, Jennifer L Hay, Alexander Shoushtari, Yuelin Li, Daniel J Paucar, Sloane C Smith, Ragini R Kudchadkar, Austin Doyle, Jeffrey A Sosman, Jorge Fernando Quevedo, Mohammed M Milhem, Anthony M Joshua, Gerald P Linette, Thomas F Gajewski, Jose Lutzky, David H Lawson, Christopher D Lao, Patrick J Flynn, Mark R Albertini, Takami Sato, Karl Lewis, Brian Marr, David H Abramson, Mark Andrew Dickson, Gary K Schwartz, Richard D Carvajal
PURPOSE: Clinical trials commonly use physician-adjudicated adverse event (AE) assessment via the common terminology criteria for adverse events (CTCAE) for decision-making. Patient-reported health-related quality of life (HRQoL) data are becoming more frequent in oncology; however, the relationship between physician-adjudicated AE assessment and HRQoL is understudied. METHODS: Data from a phase II trial (clinicaltrials.gov identifier: NCT01143402) where patients with metastatic uveal melanoma were randomized to receive selumetinib, an oral MEK inhibitor, or chemotherapy were analyzed...
December 5, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27920129/chronic-inhibition-of-renal-outer-medullary-potassium-channel-not-only-prevented-but-also-reversed-development-of-hypertension-and-end-organ-damage-in-dahl-salt-sensitive-rats
#7
Xiaoyan Zhou, Michael J Forrest, Wanda Sharif-Rodriguez, Gail Forrest, Daphne Szeto, Olga Urosevic-Price, Yonghua Zhu, Andra S Stevenson, Yuchen Zhou, Sloan Stribling, Maya Dajee, Shawn P Walsh, Alexander Pasternak, Kathleen A Sullivan
The renal outer medullary potassium (ROMK) channel mediates potassium recycling and facilitates sodium reabsorption through the Na(+)/K(+)/2Cl(-) cotransporter in the loop of Henle and potassium secretion at the cortical collecting duct. Evidence from the phenotype of humans and rodents with functional ROMK deficiency supports the contention that selective ROMK inhibitors (ROMKi) will represent a novel diuretic with potential of therapeutic benefit for hypertension. ROMKi have recently been synthesized by Merck & Co, Inc...
December 5, 2016: Hypertension
https://www.readbyqxmd.com/read/27920072/clinic-blood-pressure-underestimates-ambulatory-blood-pressure-in-an-untreated-employer-based-us-population-results-from-the-masked-hypertension-study
#8
Joseph E Schwartz, Matthew M Burg, Daichi Shimbo, Joan E Broderick, Arthur A Stone, Joji Ishikawa, Richard Sloan, Tyla Yurgel, Steven Grossman, Thomas G Pickering
BACKGROUND: Ambulatory blood pressure (ABP) is consistently superior to clinic blood pressure (CBP) as a predictor of cardiovascular morbidity and mortality risk. A common perception is that ABP is usually lower than CBP. The relationship of the CBP minus ABP difference to age has not been examined in the United States. METHODS: Between 2005 and 2012, 888 healthy, employed, middle-aged (mean±SD age, 45±10.4 years) individuals (59% female, 7.4% black, 12% Hispanic) with screening BP <160/105 mm Hg and not taking antihypertensive medication completed 3 separate clinic BP assessments and a 24-hour ABP recording for the Masked Hypertension Study...
December 6, 2016: Circulation
https://www.readbyqxmd.com/read/27919990/validation-and-enhancement-of-the-clinicopathological-melanoma-nomogram-via-incorporation-of-a-molecular-marker-in-the-primary-tumor
#9
Samer A Naffouje, Rand Naffouje, Jinsong Chen, George I Salti
BACKGROUND/AIM: To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expression in primary melanoma cells can serve as a predictor of nodal status. Many efforts to identify the nodal spread in cutaneous melanoma using non-invasive means have been recently undertaken...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919503/binocular-low-contrast-letter-acuity-and-the-symbol-digit-modalities-test-improve-the-ability-of-the-multiple-sclerosis-functional-composite-to-predict-disease-in-pediatric-multiple-sclerosis
#10
Amy T Waldman, Salim Chahin, Amy M Lavery, Geraldine Liu, Brenda L Banwell, Grant T Liu, Laura J Balcer
BACKGROUND: Outcome measures to capture disability, such as the Multiple Sclerosis Functional Composite (MSFC), were developed to enhance outcome measurements for clinical trials in adults with multiple sclerosis (MS). The MSFC initially included three components: a timed 25-foot walk [T25FW], 9-hole peg test [9HPT], and the Paced Auditory Serial Addition Task [PASAT]. Modifications to the original MSFC, such as adding binocular low-contrast letter acuity (LCLA) or substituting the symbol digit modalities test (SDMT) for the PASAT, improved the capacity to capture neurologic impairment in adults...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919490/quantitative-visual-tests-after-poorly-recovered-optic-neuritis-due-to-multiple-sclerosis
#11
Erin E Longbrake, Samantha Lancia, Nhial Tutlam, Kathryn Trinkaus, Robert T Naismith
BACKGROUND: Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. OBJECTIVE: Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina structure, electrophysiologic function, and quality of life among MS patients with moderate/severe visual dysfunction. METHODS: Cross-sectional study of 46 patients with stable, incompletely recovered optic neuritis...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918762/alternating-treatment-with-pazopanib-and-everolimus-vs-continuous-pazopanib-to-delay-disease-progression-in-patients-with-metastatic-clear-cell-renal-cell-cancer-the-ropetar-randomized-clinical-trial
#12
Geert A Cirkel, Paul Hamberg, Stefan Sleijfer, Olaf J L Loosveld, M Wouter Dercksen, Maartje Los, Marco B Polee, Franchette van den Berkmortel, Maureen J Aarts, Laurens V Beerepoot, Gerard Groenewegen, Martijn P Lolkema, Metin Tascilar, Johanna E A Portielje, Frank P J Peters, Heinz-Josef Klümpen, Vincent van der Noort, John B A G Haanen, Emile E Voest
Importance: To our knowledge, this is the first randomized clinical trial evaluating an alternating treatment regimen in an attempt to delay disease progression in clear cell renal cell carcinoma. Objective: To test our hypothesis that an 8-week rotating treatment schedule with pazopanib and everolimus delays disease progression, exhibits more favorable toxic effects, and improves quality of life when compared with continuous treatment with pazopanib. Design, Setting, and Participants: This was an open-label, randomized (1:1) study (ROPETAR trial)...
December 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27917376/evaluation-of-an-intervention-to-improve-essential-obstetric-and-newborn-care-access-and-quality-in-cotopaxi-ecuador
#13
Edward Broughton, Jorge Hermida, Kathleen Hill, Nancy Sloan, Mario Chavez, Daniel Gonzalez, Juana Maria Freire, Ximena Gudino
BACKGROUND: Despite improvements in health-care utilization, disadvantages persist among rural, less educated, and indigenous populations in Ecuador. The United States Agency for International Development-funded Cotopaxi Project created a provincial-level network of health services, including community agents to improve access, quality, and coordination of essential obstetric and newborn care. We evaluated changes in participating facilities compared to non-participating controls. METHODS: The 21 poorest parishes (third-level administrative unit) in Cotopaxi were targeted from 2010 to 2013 for a collaborative health system performance improvement...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27917264/systemic-to-pulmonary-artery-pressure-ratio-as-a-predictor-of-patient-outcome-following-liver-transplantation
#14
Annette Rebel, Dung Nguyen, Brooke Bauer, Paul A Sloan, Amy DiLorenzo, Zaki-Udin Hassan
AIM: To assess the value of the mean systemic-to-pulmonary artery pressure (MAP/mPAP) ratio for predicting outcomes following orthotopic liver transplant (OLT). METHODS: A retrospective data analysis was performed and data (mean arterial blood pressure, mean pulmonary artery pressure and Cardiac Index) were collected at several points during OLT. Outcomes evaluated were duration of postoperative endotracheal intubation [ET; minutes after intensive care unit (ICU) arrival], length of ICU stay, total hospitalization and frequency of immediate postoperative complications...
November 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27916477/modulation-of-a-circulating-uremic-solute-via-rational-genetic-manipulation-of-the-gut-microbiota
#15
A Sloan Devlin, Angela Marcobal, Dylan Dodd, Stephen Nayfach, Natalie Plummer, Tim Meyer, Katherine S Pollard, Justin L Sonnenburg, Michael A Fischbach
Renal disease is growing in prevalence and has striking co-morbidities with metabolic and cardiovascular disease. Indoxyl sulfate (IS) is a toxin that accumulates in plasma when kidney function declines and contributes to the progression of chronic kidney disease. IS derives exclusively from the gut microbiota. Bacterial tryptophanases convert tryptophan to indole, which is absorbed and modified by the host to produce IS. Here, we identify a widely distributed family of tryptophanases in the gut commensal Bacteroides and find that deleting this gene eliminates the production of indole in vitro...
November 24, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27911188/tuning-the-ribosome-the-influence-of-rrna-modification-on-eukaryotic-ribosome-biogenesis-and-function
#16
Katherine E Sloan, Ahmed S Warda, Sunny Sharma, Karl-Dieter Entian, Denis L J Lafontaine, Markus T Bohnsack
Ribosomal RNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilise the structure of the ribosome. However, they also cluster at functionally important sites of the ribosome, such as the peptidyltransferase centre and the decoding site, where they facilitate efficient and accurate protein synthesis. The recent identification of sites of substoichiometric 2'-O-methylation and pseudouridylation has overturned the notion that all rRNA modifications are constitutively present on ribosomes, highlighting nucleotide modifications as an important source of ribosomal heterogeneity...
December 2, 2016: RNA Biology
https://www.readbyqxmd.com/read/27909972/can-we-estimate-short-and-intermediate-term-survival-in-patients-undergoing-surgery-for-metastatic-bone-disease
#17
Jonathan A Forsberg, Rikard Wedin, Patrick J Boland, John H Healey
BACKGROUND: Objective means of estimating survival can be used to guide surgical decision-making and to risk-stratify patients for clinical trials. Although a free, online tool ( www.pathfx.org ) can estimate 3- and 12-month survival, recent work, including a survey of the Musculoskeletal Tumor Society, indicated that estimates at 1 and 6 months after surgery also would be helpful. Longer estimates help justify the need for more durable and expensive reconstructive options, and very short estimates could help identify those who will not survive 1 month and should not undergo surgery...
December 1, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27902946/social-regulation-of-the-lymph-node-transcriptome-in-rhesus-macaques-macaca-mulatta
#18
K Chun, J P Capitanio, D M Lamkin, E K Sloan, J M G Arevalo, S W Cole
Previous research has shown that adverse social conditions may promote a conserved transcriptional response to adversity (CTRA) involving up-regulation of proinflammatory gene expression and down-regulation of Type I interferon anti-viral genes in circulating blood cells. However, the impact of social conditions on lymphoid tissue gene regulation remains largely unexplored. This project assessed how social instability in adult male rhesus macaques (N=10, 5 in unstable, and 5 in stable social conditions) might regulate gene expression within secondary lymphoid tissue (lymph nodes; LN)...
November 14, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27901350/blood-transfusion-requirement-and-not-preoperative-anaemia-is-associated-with-perioperative-complications-following-intracorporeal-robotic-assisted-radical-cystectomy
#19
Wei Shen Tan, Benjamin Wilfrid Lamb, Pramit Khetrapal, Mae-Yen Tan, Melanie El Tan, Ashwin Sridhar, Elizabeth Cervi, Simon Rodney, Gerald Busuttil, Senthil Nathan, John Hines, Greg Shaw, Anna Mohammed, Hilary Baker, Timothy P Briggs, Andrew Klein, Toby Richards, John D Kelly
OBJECTIVES: To assess the prevalence of preoperative anaemia and the impact of preoperative anaemia and blood transfusion requirement on 30- and 90-day complications in a cohort of patients undergoing robotic assisted radical cystectomy with intracorporeal urinary diversion (iRARC). PATIENTS & METHODS: IRARC was performed on 166 patients between June 2011-March 2016. Prospective data was collected for patient demographics, clinical and pathological characteristics, perioperative variables, transfusion requirements and hospital length of stay...
November 30, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27897997/thermal-resilience-of-feeding-kinematics-may-contribute-to-the-spread-of-invasive-fishes-in-light-of-climate-change
#20
Ralph Turingan, Tyler Sloan
As a consequence of global warming, tropical invasive species are expected to expand their range pole-ward, extending their negative impacts to previously undisturbed, high-latitude ecosystems. Investigating the physiological responses of invasive species to environmental temperature is important because the coupled effects of climate change and species invasion on ecosystems could be more alarming than the effects of each phenomenon independently. Especially in poikilotherms, the rate of motion in muscle-driven biomechanical systems is expected to double for every 10 °C increase in temperature...
November 25, 2016: Biology
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