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https://www.readbyqxmd.com/read/28097324/molecular-based-recursive-partitioning-analysis-model-for-glioblastoma-in-the-temozolomide-era-a-correlative-analysis-based-on-nrg-oncology-rtog-0525
#1
Erica Hlavin Bell, Stephanie L Pugh, Joseph P McElroy, Mark R Gilbert, Minesh Mehta, Alexander C Klimowicz, Anthony Magliocco, Markus Bredel, Pierre Robe, Anca-L Grosu, Roger Stupp, Walter Curran, Aline P Becker, Andrea L Salavaggione, Jill S Barnholtz-Sloan, Kenneth Aldape, Deborah T Blumenthal, Paul D Brown, Jon Glass, Luis Souhami, R Jeffrey Lee, David Brachman, John Flickinger, Minhee Won, Arnab Chakravarti
Importance: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. Objective: To refine the existing clinically based recursive partitioning analysis (RPA) model by incorporating molecular variables. Design, Setting, and Participants: NRG Oncology RTOG 0525 specimens (n = 452) were analyzed for protein biomarkers representing key pathways in GBM by a quantitative molecular microscopy-based approach with semiquantitative immunohistochemical validation...
January 12, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28093801/from-questions-to-answers-examining-the-role-of-pediatric-surveillance-units-in-eating-disorder-research
#2
Debra K Katzman, Sloane Madden, Dasha Nicholls, Karizma Mawjee, Mark L Norris
Pediatric Surveillance Units (PSUs) provide a unique model for the study of pediatric eating disorders (EDs). Australia, Britain, and Canada have surveillance programs that have generated valuable epidemiological and clinical data on early-onset eating disorders (EOED). The PSUs represent an important collaborative tool that has helped shape our understanding of EOEDs and offers potential to contribute to decisions regarding health resource allocation and public health policy. This paper reviews the role of PSUs as a unique model to study pediatric EDs and its success in translating the knowledge generated by these programs into improving the health of children and adolescents with EDs worldwide...
January 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28092823/ph-lactate-and-hypoxia-reciprocity-in-regulating-high-affinity-monocarboxylate-transporter-expression-in-glioblastoma
#3
James P Caruso, Brandon J Koch, Philip D Benson, Elsa Varughese, Michael D Monterey, Amy E Lee, Ajal M Dave, Sam Kiousis, Andrew E Sloan, Saroj P Mathupala
Highly malignant brain tumors harbor the aberrant propensity for aerobic glycolysis, the excessive conversion of glucose to lactic acid even in the presence of ample tissue oxygen. Lactic acid is rapidly effluxed to the tumor microenvironment via a group of plasma-membrane transporters denoted monocarboxylate transporters (MCTs) to prevent "self-poisoning." One isoform, MCT2, has the highest affinity for lactate and thus should have the ability to respond to microenvironment conditions such as hypoxia, lactate, and pH to help maintain high glycolytic flux in the tumor...
January 13, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28079576/mixed-gangliocytoma-pituitary-adenoma-insights-on-the-pathogenesis-of-a-rare-sellar-tumor
#4
M Beatriz S Lopes, Emily Sloan, Julie Polder
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors...
January 10, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28072482/a-systematic-review-of-evidence-relating-to-clinical-supervision-for-nurses-midwives-and-allied-health-professionals
#5
REVIEW
Alex Pollock, Pauline Campbell, Ruth Deery, Mick Fleming, Jean Rankin, Graham Sloan, Helen Cheyne
AIM: To systematically review evidence relating to clinical supervision for nurses, midwives and allied health professionals. BACKGROUND: Since 1902 statutory supervision has been a requirement for UK midwives, but this is due to change. Evidence relating to clinical supervision for nurses and allied health professions could inform a new model of clinical supervision for midwives. DESIGN: A systematic review with a contingent design, comprising a broad map of research relating to clinical supervision and two focussed syntheses answering specific review questions...
January 10, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28056874/sorafenib-versus-sunitinib-as-first-line-treatment-agents-in-chinese-patients-with-metastatic-renal-cell-carcinoma-the-largest-multicenter-retrospective-analysis-of-survival-and-prognostic-factors
#6
Hai-Liang Zhang, Xi-Nan Sheng, Xue-Song Li, Hong-Kai Wang, Zhi-Hong Chi, Zhi-Song He, Ding-Wei Ye, Jun Guo
BACKGROUND: To compare the efficacy of sorafenib and sunitinib with regard to overall survival (OS) and progression free survival (PFS) in Chinese patients with metastatic renal cell carcinoma (mRCC). METHODS: A multicenter, retrospective study was performed to elucidate the relationship between clinical variables and prognosis comparing sorafenib and sunitinib as first-line treatment agents in Chinese patients with mRCC. Between September 2006 and December 2014, 845 patients received either sorafenib (400 mg bid; n = 483) or sunitinib (50 mg q...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28056493/alcohol-impaired-driving-and-perceived-risks-of-legal-consequences
#7
Frank A Sloan, Sabrina A McCutchan, Lindsey M Eldred
BACKGROUND: Driving while impaired (DWI) is a threat to public health. Codified legal sanctions are a widely implemented strategy to reduce DWI. However, it is unclear that sanctioning affects individual risk perceptions so as to deter alcohol-impaired driving. METHODS: Using survey data collected from individual drivers, police, and defense attorneys specializing in DWI in 8 U.S. cities, we investigated whether risk perceptions about legal consequences for alcohol-impaired driving, both the risk of being stopped if driving while alcohol-impaired and receiving specific penalties following a DWI, deter alcohol-impaired driving...
January 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#8
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28047734/su-f-t-599-volume-independent-conformity-index-for-stereotactic-brain-tumors
#9
S Kim, H Kim, S Lee, M Awan, D Rangaraj, Y Zheng, J Monroe, R Partel, S Lo, M Machtay, A Sloan, J Sohn
PURPOSE: To develop a volume-independent metric called the Gaussian Weighted Conformity Index (GWCI) for assessing conformality of stereotactic radiosurgery plans for small brain tumors. METHODS: The GWCI calculates bi-directional distance by searching for corresponding points between the prescription isodose line and tumor contour, assigning different scoring weights to tumor coverage with a score of 1.0 being ideal assuming an idealized Gaussian distribution of dose around the tumor...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046521/we-b-201-02-statistical-failings-that-can-keep-us-all-in-the-dark
#10
J Sloan
: Evidence is growing to suggest that many published clinical results cannot be replicated. At the same time, the number of published clinical papers is steadily increasing and most if not all base their conclusions on evidence provided by formal statistical tests. Medical physicists have a critical need to understand and be able to interpret the methods and results of these studies in order to judge their scientific quality and relevance. However many medical physicists have minimal or no training in the sort of practical statistical methods commonly found in the literature...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041324/frequency-of-symptomatic-vertebral-body-compression-fractures-requiring-intervention-following-single-fraction-stereotactic-radiosurgery-for-spinal-metastases
#11
Michael S Virk, James E Han, Anne S Reiner, Lily A McLaughlin, Daniel M Sciubba, Eric Lis, Yoshiya Yamada, Mark Bilsky, Ilya Laufer
OBJECTIVE The purpose of this study was to determine the rate of symptomatic vertebral body compression fractures (VCFs) requiring kyphoplasty or surgery in patients treated with 24-Gy single-fraction stereotactic radiosurgery (SRS). METHODS This retrospective analysis included all patients who had been treated with 24-Gy, single-fraction, image-guided intensity-modulated radiation therapy for histologically confirmed solid tumor metastases over an 8-year period (2005-2013) at Memorial Sloan Kettering Cancer Center...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28041314/spinal-stereotactic-body-radiotherapy-following-intralesional-curettage-with-separation-surgery-for-initial-or-salvage-chordoma-treatment
#12
Dennis T Lockney, Timothy Shub, Benjamin Hopkins, Natalie A Lockney, Nelson Moussazadeh, Eric Lis, Yoshiya Yamada, Adam M Schmitt, Daniel S Higginson, Ilya Laufer, Mark Bilsky
OBJECTIVE Chordoma is a rare malignant tumor for which en bloc resection with wide margins is advocated as primary treatment. Unfortunately, due to anatomical constraints, en bloc resection to achieve wide or marginal margins is not feasible for many patients as the resulting morbidity would be prohibitive. The objective of this study was to evaluate the efficacy of intralesional curettage and separation surgery followed by spinal stereotactic body radiation therapy (SBRT) in patients with chordomas in the mobile spine...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28040784/genetic-analysis-of-the-lambda-spanins-rz-and-rz1-identification-of-functional-domains
#13
Jesse Cahill, Manoj Rajaure, Chandler O'Leary, Jordan Sloan, Armando Marrufo, Ashley Holt, Aneesha Kulkarni, Oscar Hernandez, Ry Young
Coliphage lambda proteins Rz and Rz1 are the inner membrane and outer membrane subunits of the spanin complex, a heterotetramer that bridges the periplasm and is essential for the disruption of the outer membrane during phage lysis. Recent evidence suggests the spanin complex functions by fusing the inner and outer membrane. Here we use a genetics approach to investigate and characterize determinants of spanin function. Because Rz1 is entirely embedded in the +1 reading frame of Rz, the genes were dis-embedded before using random mutagenesis to construct a library of lysis-defective alleles for both genes...
December 30, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28040701/thinking-critically-about-classifying-adverse-events-incidence-of-pancreatitis-in-patients-treated-with-nivolumab-ipilimumab
#14
Claire F Friedman, Varina Clark, Andrew V Raikhel, Tim Barz, Alexander N Shoushtari, Parisa Momtaz, Margaret K Callahan, Jedd D Wolchok, Paul B Chapman, Matthew D Hellmann, Michael A Postow
The Common Terminology Criteria for Adverse Events (CTCAE) were developed to document the adverse effects of chemotherapy but are now also used to document immune-related adverse events (irAE). Characterization of irAE by the CTCAE has implications for determining dose-limiting toxicity (DLT) and, consequently, the recommended phase II dose (RP2D) of investigational agents. In the phase I trial of nivolumab + ipilimumab, an asymptomatic increase in lipase was the primary DLT that informed the RP2D. We performed a retrospective study of 119 patients with melanoma who were treated at Memorial Sloan Kettering Cancer Center with the combination of nivolumab + ipilimumab to investigate the relationship between asymptomatic grade 3 or higher increases in amylase and/or lipase and pancreatitis, a known irAE...
April 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28040534/cardiovascular-risk-factors-in-survivors-of-childhood-hematopoietic-cell-transplantation-treated-with-total-body-irradiation-a-longitudinal-analysis
#15
Danielle Novetsky Friedman, Patrick Hilden, Chaya S Moskowitz, Maya Suzuki, Farid Boulad, Nancy Kernan, Suzanne Wolden, Kevin C Oeffinger, Charles A Sklar
Hematopoietic cell transplantation (HCT) survivors treated with total body irradiation (TBI) are known to be at increased risk for the development of cardiovascular risk factors (CVRFs). We sought to characterize the incidence of CVRFs in a TBI-exposed survivor cohort and to describe prognostic indicators of their development through a retrospective analysis of CVRFs in 1-year survivors of leukemia or lymphoma treated with TBI at Memorial Sloan Kettering between April 1987 and May 2011. Eligible participants were age ≤21 years at the time of TBI and were not receiving glucocorticoid therapy at the time of entry to long-term follow-up...
December 28, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28039365/complete-prevalence-of-malignant-primary-brain-tumors-registry-data-in-the-united-states-compared-with-other-common-cancers-2010
#16
Adah S Zhang, Quinn T Ostrom, Carol Kruchko, Lisa Rogers, David M Peereboom, Jill S Barnholtz-Sloan
BACKGROUND: Complete prevalence proportions illustrate the burden of disease in a population. This study estimates the 2010 complete prevalence of malignant primary brain tumors overall and by Central Brain Tumor Registry of the United States (CBTRUS) histology groups, and compares the brain tumor prevalence estimates to the complete prevalence of other common cancers as determined by the Surveillance, Epidemiology, and End Results Program (SEER) by age at prevalence (2010): children (0-14 y), adolescent and young adult (AYA) (15-39 y), and adult (40+ y)...
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28038932/pretreatment-lymphocyte-to-monocyte-ratio-is-an-independent-prognostic-factor-in-metastatic-clear-cell-renal-cell-carcinoma
#17
Liangyou Gu, Xin Ma, Yongpeng Xie, Hongzhao Li, Lei Wang, Luyao Chen, Wenlei Zhao, Yu Zhang, Xu Zhang
BACKGROUND: The prognostic value of pretreatment lymphocyte to monocyte ratio (LMR) in metastatic clear cell renal cell carcinoma (ccRCC) is not well-described. The purpose of this study was to assess the prognostic role of pretreatment LMR in surgically treated metastatic ccRCC. PATIENTS AND METHODS: One hundred forty-five patients with metastatic ccRCC who underwent cytoreductive nephrectomy between 2006 and 2013 at our institute were identified. Pretreatment LMR was calculated within 1 week before surgical intervention...
December 13, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28034994/mr-fingerprinting-of-adult-brain-tumors-initial-experience
#18
C Badve, A Yu, S Dastmalchian, M Rogers, D Ma, Y Jiang, S Margevicius, S Pahwa, Z Lu, M Schluchter, J Sunshine, M Griswold, A Sloan, V Gulani
BACKGROUND AND PURPOSE: MR fingerprinting allows rapid simultaneous quantification of T1 and T2 relaxation times. This study assessed the utility of MR fingerprinting in differentiating common types of adult intra-axial brain tumors. MATERIALS AND METHODS: MR fingerprinting acquisition was performed in 31 patients with untreated intra-axial brain tumors: 17 glioblastomas, 6 World Health Organization grade II lower grade gliomas, and 8 metastases. T1, T2 of the solid tumor, immediate peritumoral white matter, and contralateral white matter were summarized within each ROI...
December 29, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28032183/a-prospective-case-control-study-of-functional-outcomes-and-related-quality-of-life-after-colectomy-for-neoplasia
#19
Adela Brigic, Samia Sakuma, Richard E Lovegrove, Paul Bassett, Omar Faiz, Susan K Clark, Neil Mortensen, Robin H Kennedy
AIM: Our aim was to assess bowel function and its effect on overall quality of life (QOL) when compared to healthy controls after colectomy. METHODS: Patients undergoing resection of colorectal neoplasia were recruited pre-operatively and followed up at 6 and 12 months, to assess 'early' bowel function. Patients who underwent surgery 2 to 4 years previously were recruited for assessment of 'intermediate' bowel function. Healthy relatives were recruited as controls...
December 28, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28028762/screening-for-thyroid-cancer-in-survivors-of-childhood-and-young-adult-cancer-treated-with-neck-radiation
#20
Emily S Tonorezos, Dana Barnea, Chaya S Moskowitz, Joanne F Chou, Charles A Sklar, Elena B Elkin, Richard J Wong, Duan Li, R Michael Tuttle, Deborah Korenstein, Suzanne L Wolden, Kevin C Oeffinger
BACKGROUND: The optimal method of screening for thyroid cancer in survivors of childhood and young adult cancer exposed to neck radiation remains controversial. Outcome data for a physical exam-based screening approach are lacking. METHODS: We conducted a retrospective review of adult survivors of childhood and young adult cancer with a history of neck radiation followed in the Adult Long-Term Follow-Up Clinic at Memorial Sloan Kettering between November 2005 and August 2014...
December 27, 2016: Journal of Cancer Survivorship: Research and Practice
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