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https://www.readbyqxmd.com/read/28417551/morbidity-and-mortality-after-treatment-of-ewing-sarcoma-a-single-institution-experience
#1
Danielle Novetsky Friedman, Katherine Chastain, Joanne F Chou, Chaya S Moskowitz, Roberto Adsuar, Leonard H Wexler, Alexander J Chou, Amelia DeRosa, Joanne Candela, Heather Magnan, Shawn Pun, Tamara Kahan, Suzanne L Wolden, Paul A Meyers, Kevin C Oeffinger
BACKGROUND: Children, adolescents, and young adults treated for Ewing sarcoma (ES) are at risk for disease-related and treatment-related complications. We aimed to describe early and late overall mortality, cause-specific mortality, and key adverse health outcomes in a large, single-institutional cohort of patients with ES. METHODS: Patients with ES diagnosed at age less than 40 years and treated at Memorial Sloan Kettering between 1974 and 2012 were included. Overall survival was estimated using Kaplan-Meier methods...
April 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28417203/effects-of-diet-and-exercise-on-weight-related-outcomes-for-breast-cancer-survivors-and-their-adult-daughters-an-analysis-of-the-dames-trial
#2
Danielle B Tometich, Catherine E Mosher, Joseph G Winger, Hoda J Badr, Denise C Snyder, Richard J Sloane, Wendy Demark-Wahnefried
PURPOSE: Few trials have aimed to promote diet and exercise behaviors in both cancer survivors and their family members and examine their associations with weight-related outcomes. We conducted a secondary analysis to examine associations between change in diet and exercise behaviors and weight-related outcomes for overweight breast cancer survivors and their overweight adult daughters in the Daughters And MothErS Against Breast Cancer (DAMES) randomized trial. METHODS: The DAMES trial assessed the impact of two iteratively tailored, mailed print diet and exercise interventions against standard brochures over a 12-month period...
April 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28412094/emotional-problems-quality-of-life-and-symptom-burden-in-patients-with-lung-cancer
#3
Eleshia J Morrison, Paul J Novotny, Jeff A Sloan, Ping Yang, Christi A Patten, Kathryn J Ruddy, Matthew M Clark
OBJECTIVES: Lung cancer is associated with a greater symptom burden than other cancers, yet little is known about the prevalence of emotional problems and how emotional problems may be related to the physical symptom burden and quality of life in newly diagnosed patients with lung cancer. This study aimed to identify the patient and disease characteristics of patients with lung cancer experiencing emotional problems and to examine how emotional problems relate to quality of life and symptom burden...
March 2, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28412062/development-and-internal-validation-of-a-novel-model-to-identify-the-candidates-for-extended-pelvic-lymph-node-dissection-in-prostate-cancer
#4
Giorgio Gandaglia, Nicola Fossati, Emanuele Zaffuto, Marco Bandini, Paolo Dell'Oglio, Carlo Andrea Bravi, Giuseppe Fallara, Francesco Pellegrino, Luigi Nocera, Pierre I Karakiewicz, Zhe Tian, Massimo Freschi, Rodolfo Montironi, Francesco Montorsi, Alberto Briganti
BACKGROUND: Preoperative assessment of the risk of lymph node invasion (LNI) is mandatory to identify prostate cancer (PCa) patients who should receive an extended pelvic lymph node dissection (ePLND). OBJECTIVE: To update a nomogram predicting LNI in contemporary PCa patients with detailed biopsy reports. DESIGN, SETTING, AND PARTICIPANTS: Overall, 681 patients with detailed biopsy information, evaluated by a high-volume uropathologist, treated with radical prostatectomy and ePLND between 2011 and 2016 were identified...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28410987/alkaline-phosphatase-velocity-predicts-overall-survival-and-bone-metastasis-in-patients-with-castration-resistant-prostate-cancer
#5
Kai H Hammerich, Timothy F Donahue, Inger L Rosner, Jennifer Cullen, Huai-Ching Kuo, Lauren Hurwitz, Yongmei Chen, Melanie Bernstein, Jonathan Coleman, Daniel C Danila, Adam R Metwalli
INTRODUCTION AND OBJECTIVES: Identifying patients with prostate cancer (CaP) who will ultimately develop bone metastasis (BM) or die of disease is essential. Alkaline phosphatase velocity (APV) has been shown to predict overall survival (OS) and bone metastasis-free survival (BMFS) in an earlier study of an equal access military patient cohort of patients with castrate-resistant prostate cancer (CRPC). To confirm these findings, we examined a cohort of patients from a high-volume cancer center to validate a previous observation that faster alkaline phosphatase (AP) kinetics are predictive of OS and BMFS in this second cohort of patients...
April 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28409832/influence-of-neoadjuvant-chemotherapy-on-resection-of-primary-colorectal-liver-metastases-a-propensity-score-analysis
#6
Moritz J Strowitzki, Thomas Schmidt, Ulrich Keppler, Alina S Ritter, Sarah Mahmoud, Johannes Klose, André L Mihaljevic, Martin Schneider, Markus W Büchler, Alexis B Ulrich
BACKGROUND AND OBJECTIVES: There is ongoing debate about whether patients planned for liver resection of colorectal liver metastases (CRLM) benefit from neoadjuvant chemotherapy (NC). Therefore, we performed a retrospective survival analysis of patients with and without NC prior to surgery. METHODS: Data prospectively collected from 468 consecutive patients were analyzed in a retrospective design. We performed a survival analysis and added propensity score matching (PSM)...
April 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28406018/synthesis-of-hiv-maturation-inhibitor-bms-955176-from-betulin-by-an-enabling-oxidation-strategy
#7
Adrian Ortiz, Maxime Soumeillant, Scott A Savage, Neil A Strotman, Matthew Haley, Tamas Benkovics, Jeffrey Nye, Zhongmin Xu, Yichen Tan, Sloan Ayers, Qi Gao, Susanne Kiau
A concise and scalable 2nd generation synthesis of HIV maturation inhibitor BMS-955176 is described. The synthesis is framed by an oxidation strategy highlighted by a CuI mediated aerobic oxidation of betulin, a highly selective PIFA mediated dehydrogenation of an oxime, and a subsequent Lossen rearrangement which occurs through a unique reaction mechanism for the installation of the C17 amino functionality. The synthetic route proceeds in 7 steps, 47% overall yield, and begins from the abundant and inexpensive natural product betulin...
April 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28403457/smoking-cessation-support-by-text-message-during-pregnancy-a-qualitative-study-of-views-and-experiences-of-the-miquit-intervention
#8
Melanie Sloan, Sarah Hopewell, Tim Coleman, Sue Cooper, Felix Naughton
Introduction: SMS text messaging is increasingly used for delivering smoking cessation support and pilot studies suggest this may also be useful in pregnancy. This study explores the views of women who received a tailored text messaging cessation intervention (MiQuit) during pregnancy, focusing on acceptability, perceived impact, and suggestions for improvements. Methods: Semi-structured interviews were undertaken with 15 purposively sampled women who had received the MiQuit intervention during pregnancy as part of a randomized controlled trial...
May 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28403240/snovault-and-encoded-a-novel-object-based-storage-system-and-applications-to-encode-metadata
#9
Benjamin C Hitz, Laurence D Rowe, Nikhil R Podduturi, David I Glick, Ulugbek K Baymuradov, Venkat S Malladi, Esther T Chan, Jean M Davidson, Idan Gabdank, Aditi K Narayana, Kathrina C Onate, Jason Hilton, Marcus C Ho, Brian T Lee, Stuart R Miyasato, Timothy R Dreszer, Cricket A Sloan, J Seth Strattan, Forrest Y Tanaka, Eurie L Hong, J Michael Cherry
The Encyclopedia of DNA elements (ENCODE) project is an ongoing collaborative effort to create a comprehensive catalog of functional elements initiated shortly after the completion of the Human Genome Project. The current database exceeds 6500 experiments across more than 450 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory and transcriptional landscape of the H. sapiens and M. musculus genomes. All ENCODE experimental data, metadata, and associated computational analyses are submitted to the ENCODE Data Coordination Center (DCC) for validation, tracking, storage, unified processing, and distribution to community resources and the scientific community...
2017: PloS One
https://www.readbyqxmd.com/read/28402908/current-treatment-trends-and-the-need-for-better-predictive-tools-in-the-management-of-ductal-carcinoma-in-situ-of-the-breast
#10
REVIEW
Carlos Martínez-Pérez, Arran K Turnbull, Gregory E Ekatah, Laura M Arthur, Andrew H Sims, Jeremy S Thomas, J Michael Dixon
Ductal carcinoma in situ (DCIS) of the breast represents a group of heterogeneous non-invasive lesions the incidence of which has risen dramatically since the advent of mammography screening. In this review we summarise current treatment trends and up-to-date results from clinical trials studying surgery and adjuvant therapy alternatives, including the recent consensus on excision margin width and its role in decision-making for post-excision radiotherapy. The main challenge in the clinical management of DCIS continues to be the tailoring of treatment to individual risk, in order to avoid the over-treatment of low-risk lesions or under-treatment of DCIS with higher risk of recurring or progressing into invasion...
March 31, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28399800/tst-positivity-in-household-contacts-of-tuberculosis-patients-a-case-contact-study-in-malawi
#11
Jonas Hector, Suzanne T Anderson, Gertrude Banda, Mercy Kamdolozi, Laura F Jefferys, Doris Shani, Natalie J Garton, Agnes Mwale, Annie Jobe, Geraint R Davies, Derek J Sloan
BACKGROUND: Screening household contacts of active tuberculosis (TB) patients is recommended for TB control. Due to resource constraints this rarely occurs in lower income countries. Demographic and clinical features of index cases may influence the likelihood of onwards TB transmission. It has also been proposed that accumulation of intracellular lipid bodies within M. tuberculosis cells may also enhance bacterial transmissibility. This study explored whether clinical and bacteriological observations recorded at baseline in TB cases in Malawi could help identify those with the highest risk of onwards transmission, to prioritise contact tracing...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28398634/ski-regulates-smads-and-taz-signaling-to-suppress-lung-cancer-progression
#12
Mian Xie, Xiaojun Wu, Jinjun Zhang, Jiexia Zhang, Xiangxiang Li
Ski, the transforming protein of the avian Sloan-Kettering retrovirus, displays both pro-oncogenic and anti-oncogenic activities in human cancer. The mechanisms underlying these conflicting observations have not been fully understood. Herein, we investigated the mechanism underlying the tumor suppressor activity of Ski. To investigate the effect of Ski re-activation on TGF-β and Hippo/TAZ pathway, we measured its effect on the endogenous Smad target genes (PAI-1 and P15(INK4B) ) and TAZ target gene CTGF. The results revealed that Ski exerted its inhibitory activity in TGF-β1/Smad signaling pathway...
April 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28397028/incidence-and-survival-trends-in-oligodendrogliomas-and-anaplastic-oligodendrogliomas-in-the-united-states-from-2000-to-2013-a-cbtrus-report
#13
Rebecca L Achey, Vishesh Khanna, Quinn T Ostrom, Carol Kruchko, Jill S Barnholtz-Sloan
Measuring tumor-specific trends in incidence is necessary to elucidate tumor-type contribution to overall cancer burden in the US population. Recently, there have been conflicting reports concerning the incidence of oligodendrogliomas (OD) and anaplastic oligodendrogliomas (AOD). Therefore, our goal was to examine trends in OD and AOD incidence and survival by age, gender and race. Data was analyzed from the Central Brain Tumor Registry of the United States (CBTRUS) from 2000 to 2013. Age-adjusted incidence rates per 100,000 person-years with 95% confidence intervals (CI) and annual percent changes (APCs) with 95% CI were calculated for OD and AOD by age, sex and race...
April 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28394130/revisiting-a-classic-transformation-a-lossen-rearrangement-initiated-by-nitriles-and-pseudo-catalytic-in-isocyanate
#14
Neil A Strotman, Adrian Ortiz, Scott A Savage, Christopher R Wilbert, Sloan Ayers, Susanne Kiau
The direct conversion of a hydroxamic acid to an amine has been accomplished in a single step in the synthesis of HIV drug candidate BMS-955176. This process utilizes catalytic base and proceeds under mild conditions (CH3CN, cat. DBU, 60 °C), without the need for strong electrophiles required for typical Lossen rearrangements, and can be applied to aliphatic and aromatic hydroxamic acids. Through investigation of the kinetics of this transformation, a mechanism was revealed involving a novel initiation pathway and a self-propagation cycle...
April 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28393398/parental-strategies-used-in-the-family-meal-session-of-family-based-treatment-for-adolescent-anorexia-nervosa-links-with-treatment-outcomes
#15
Hannah J White, Emma Haycraft, Sloane Madden, Paul Rhodes, Jane Miskovic-Wheatley, Andrew Wallis, Michael Kohn, Caroline Meyer
OBJECTIVE: Examine relationships between parental mealtime strategies used in the family meal session of family-based treatment (FBT) and adolescent outcomes at EOT (session 20). METHOD: Eighteen families with an adolescent receiving FBT-AN participated. Parental strategies during videoed family meals were assessed using a family mealtime coding system. Change scores were calculated for both adolescent %EBW and EDE scores. RESULTS: Increased use of parental direct and non-direct eating prompts during the family meal was associated with greater adolescent weight gain at EOT...
April 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28390544/obesity-heuristic-reasoning-and-the-organisation-of-communicative-embarrassment-in-diagnostic-radiography
#16
P K Miller, A L Woods, C Sloane, L Booth
This paper, the second of three arising from a broader qualitative study, explores difficulties emerging around radiographer-patient communication regarding obesity in hospital-based encounters, and the situated strategies found by experienced radiographers for handling such situations. Semi-structured interviews with eight clinicians working in plain radiography (mean experience = 21.56 years) were analysed using Interpretative Phenomenological Analysis (IPA), so as to highlight the practical, nuanced and real-world experiences of these individuals regarding obesity communication...
May 2017: Radiography
https://www.readbyqxmd.com/read/28378620/the-anorexia-nervosa-genetics-initiative-study-description-and-sample-characteristics-of-the-australian-and-new-zealand-arm
#17
Katherine M Kirk, Felicity C Martin, Amy Mao, Richard Parker, Sarah Maguire, Laura M Thornton, Gu Zhu, Kerrie McAloney, Jeremy L Freeman, Phillipa Hay, Sloane Madden, Christine Morgan, Janice Russell, Susan M Sawyer, Elizabeth K Hughes, A Kate Fairweather-Schmidt, Anthea Fursland, Julie McCormack, Fiona Wagg, Jennifer Jordan, Martin A Kennedy, Warren Ward, Tracey D Wade, Cynthia M Bulik, Nicholas G Martin
OBJECTIVES: Anorexia nervosa is a severe psychiatric disorder with high mortality rates. While its aetiology is poorly understood, there is evidence of a significant genetic component. The Anorexia Nervosa Genetics Initiative is an international collaboration which aims to understand the genetic basis of the disorder. This paper describes the recruitment and characteristics of the Australasian Anorexia Nervosa Genetics Initiative sample, the largest sample of individuals with anorexia nervosa ever assembled across Australia and New Zealand...
April 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28377899/certain-less-invasive-infertility-treatments-associated-with-different-levels-of-pregnancy-related-anxiety-in-pregnancies-conceived-via-in-vitro-fertilization
#18
Eleanor Lowndes Stevenson, Richard Sloane
BACKGROUND: Research supports that in vitro fertilization causes anxiety and that anxiety can continue into the resulting pregnancy. Most women who have IVF will have a less invasive treatment for infertility prior to IVF; however, it is unclear if specific less invasive treatment cycles impact anxiety that is experienced in the pregnancy resulting from IVF. METHODS: A prospective study was conducted for women who became pregnant via IVF, and data was collected about reported previous non-IVF treatment cycles as well as Pregnancy Related Anxiety Measure...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28373300/corrigendum-a-novel-translational-control-mechanism-involving-rna-structures-within-coding-sequences
#19
Jennifer Jungfleisch, Danny D Nedialkova, Ivan Dotu, Katherine E Sloan, Neus Martinez-Bosch, Lukas Brüning, Emanuele Raineri, Pilar Navarro, Markus T Bohnsack, Sebastian A Leidel, Juana Díez
No abstract text is available yet for this article.
April 2017: Genome Research
https://www.readbyqxmd.com/read/28369756/the-antibiotic-prescribing-pathway-for-presumed-urinary-tract-infections-in-nursing-home-residents
#20
Christine E Kistler, Sheryl Zimmerman, Kezia Scales, Kimberly Ward, David Weber, David Reed, Mallory McClester, Philip D Sloane
OBJECTIVES: Due to the high rates of inappropriate antibiotic prescribing for presumed urinary tract infections (UTIs) in nursing home (NH) residents, we sought to examine the antibiotic prescribing pathway and the extent to which it agrees with the Loeb criteria; findings can suggest strategies for antibiotic stewardship. METHODS: Chart review of 260 randomly-selected cases from 247 NH residents treated with an antibiotic for a presumed UTI in 31 NHs in North Carolina...
March 28, 2017: Journal of the American Geriatrics Society
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