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https://www.readbyqxmd.com/read/27908433/central-venous-catheter-infections-in-home-parenteral-nutrition-patients-outcomes-from-sustain-american-society-for-parenteral-and-enteral-nutrition-s-national-patient-registry-for-nutrition-care
#1
Vicki M Ross, Peggi Guenter, Mandy L Corrigan, Debra Kovacevich, Marion F Winkler, Helaine E Resnick, Tina L Norris, Lawrence Robinson, Ezra Steiger
BACKGROUND: Home parenteral nutrition (HPN) is a high-cost, complex nutrition support therapy that requires the use of central venous catheters. Central line-associated bloodstream infections (CLABSIs) are among the most serious risks of this therapy. Sustain: American Society for Parenteral and Enteral Nutrition's National Patient Registry for Nutrition Care (Sustain registry) provides the most current and comprehensive data for studying CLABSI among a national cohort of HPN patients in the United States...
December 1, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27866666/why-is-there-no-c-in-nursing
#2
EDITORIAL
Barbara Resnick
No abstract text is available yet for this article.
November 17, 2016: Geriatric Nursing
https://www.readbyqxmd.com/read/27856149/accuracy-of-three-dimensional-soft-tissue-prediction-for-le-fort-i-osteotomy-using-dolphin-3d-software-a-pilot-study
#3
C M Resnick, R R Dang, S J Glick, B L Padwa
Three-dimensional (3D) soft tissue prediction is replacing two-dimensional analysis in planning for orthognathic surgery. The accuracy of different computational models to predict soft tissue changes in 3D, however, is unclear. A retrospective pilot study was implemented to assess the accuracy of Dolphin 3D software in making these predictions. Seven patients who had a single-segment Le Fort I osteotomy and had preoperative (T0) and >6-month postoperative (T1) cone beam computed tomography (CBCT) scans and 3D photographs were included...
November 14, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27850697/1059-absent-on-rounds-ventilator-waveform-analysis
#4
Priya Prakash, Randi Smith, Shelby Resnick, Niels Martin, Jose Pascual, Maurizio Cereda, Patrick Reilly, Lewis Kaplan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27834950/the-novel-p53-target-tnfaip8-variant-2-is-increased-in-cancer-and-offsets-p53-dependent-tumor-suppression
#5
Julie M Lowe, Thuy-Ai Nguyen, Sara A Grimm, Kristin A Gabor, Shyamal D Peddada, Leping Li, Carl W Anderson, Michael A Resnick, Daniel Menendez, Michael B Fessler
Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a stress-response gene that has been associated with cancer, but no studies have differentiated among or defined the regulation or function of any of its several recently described expression variants. We found that TNFAIP8 variant 2 (v2) is overexpressed in multiple human cancers, whereas other variants are commonly downregulated in cancer (v1) or minimally expressed in cancer or normal tissue (v3-v6). Silencing v2 in cancer cells induces p53-independent inhibition of DNA synthesis, widespread binding of p53, and induction of target genes and p53-dependent cell cycle arrest and DNA damage sensitization...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27834567/the-moderated-mediating-effect-of-self-efficacy-on-exercise-among-older-adults-in-an-online-bone-health-intervention-study-a-parallel-process-latent-growth-curve-modeling
#6
Shijun Zhu, Eun-Shim Nahm, Barbara Resnick, Erika Friedmann, Clayton Brown, Jumin Park, Jooyoung Cheon, DoHwan Park
OBJECTIVES: This secondary data analyses of a longitudinal study assessed whether self-efficacy for exercise (SEE) mediated an online intervention effects on exercise among older adults and whether age (50-64 vs. ≥ 65 years) moderated the mediation. METHODS: Data were from an online bone health intervention study. Eight hundred sixty-six older adults (≥ 50 years) were randomized to three arms: Bone Power (n = 301), Bone Power Plus (n = 302), or Control (n = 263)...
November 11, 2016: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/27816300/racial-variation-in-patient-reported-outcomes-following-treatment-for-localized-prostate-cancer-results-from-the-ceasar-study
#7
Mark D Tyson, JoAnn Alvarez, Tatsuki Koyama, Karen E Hoffman, Matthew J Resnick, Xiao-Cheng Wu, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Lisa E Paddock, Antoinette Stroup, Vivien W Chen, David F Penson, Daniel A Barocas
BACKGROUND: Relatively little is known about the relationship between race/ethnicity and patient-reported outcomes after contemporary treatments for localized prostate cancer. OBJECTIVE: To test the hypothesis that treatment-related changes in urinary, bowel, sexual, and hormonal function vary by race/ethnicity. DESIGN, SETTING, AND PARTICIPANTS: The Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a prospective, population-based, observational study that enrolled 3708 men diagnosed with localized prostate cancer in 2011-2012...
November 2, 2016: European Urology
https://www.readbyqxmd.com/read/27812213/hif-stabilization-weakens-primary-cilia
#8
Andrew Resnick
Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the sixties, very little is known about their functions. One suspected function is fluid flow sensing- physical bending of cilia produces an influx of Ca++, which can then result in a variety of activated signaling pathways. Defective cilia and ciliary-associated proteins have been shown to result in cystic diseases. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a progressive disease, typically appearing in the 5th decade of life and is one of the most common monogenetic inherited human diseases, affecting approximately 600,000 people in the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27811155/olfaction-is-related-to-motor-function-in-older-adults
#9
Qu Tian, Susan M Resnick, Stephanie A Studenski
BACKGROUND: Among older adults, both olfaction and motor function predict future cognitive decline and dementia, suggesting potential shared causal pathways. However, it is not known whether olfactory and motor function are independently related in late life. METHODS: We assessed cross-sectional associations of olfaction with motor and cognitive function, using concurrent data on olfactory function, mobility, balance, fine motor function, manual dexterity, and cognition in 163 Baltimore Longitudinal Study of Aging participants aged 60 and older without common neurological diseases (n = 114 with available cognitive data)...
November 3, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27801733/the-inflammatory-milieu-of-eosinophilic-esophagitis-a-contemporary-review-with-emphasis-in-putative-immunohistochemistry-and-serologic-markers
#10
Marcos Lepe, David O'Connell, Kara A Lombardo, Michael Herzlinger, Shamlal Mangray, Murray B Resnick, Andres Matoso
Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27799465/paradoxical-leanness-in-the-imprinting-centre-deletion-mouse-model-for-prader-willi-syndrome
#11
David M Golding, Daniel J Rees, Jennifer R Davies, Dinko Relkovic, Hannah V Furby, Irina A Guschina, Anna L Hopkins, Jeffrey S Davies, James L Resnick, Anthony R Isles, Timothy Wells
Prader-Willi syndrome (PWS), a neurodevelopmental disorder caused by loss of paternal gene expression from 15q11-q13, is characterised by growth retardation, hyperphagia and obesity. However, as single gene mutation mouse models for this condition display an incomplete spectrum of the PWS phenotype, we have characterised the metabolic impairment in a mouse model for 'full' PWS, in which deletion of the imprinting centre (IC) abolishes paternal gene expression from the entire PWS cluster. We show that PWS-IC(del) mice displayed postnatal growth retardation, with reduced body weight, hyperghrelinaemia and marked abdominal leanness; proportionate retroperitoneal, epididymal/omental and inguinal white adipose tissue (WAT) weights being reduced by 82%, 84% and 67%, respectively...
January 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27791083/inositol-polyphosphates-intersect-with-signaling-and-metabolic-networks-via-two-distinct-mechanisms
#12
Mingxuan Wu, Lucy S Chong, David H Perlman, Adam C Resnick, Dorothea Fiedler
Inositol-based signaling molecules are central eukaryotic messengers and include the highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs). Despite the essential cellular regulatory functions of InsPs and PP-InsPs (including telomere maintenance, phosphate sensing, cell migration, and insulin secretion), the majority of their protein targets remain unknown. Here, the development of InsP and PP-InsP affinity reagents is described to comprehensively annotate the interactome of these messenger molecules...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#13
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen, Sylvia Wassertheil-Smoller, Mimi Goodwin, Richard DeNise, Michael Lipton, James Hannigan, Anthony Carpini, David Noble, Wilton Guzman, Jane Morley Kotchen, Joseph Goveas, Diana Kerwin, John Ulmer, Steve Censky, Troy Flinton, Tracy Matusewic, Robert Prost, Marcia L Stefanick, Sue Swope, Anne Marie Sawyer-Glover, Susan Hartley, Rebecca Jackson, Rose Hallarn, Bonnie Kennedy, Jill Bolognone, Lindsay Casimir, Amanda Kochis, John Robbins, Sophia Zaragoza, Cameron Carter, John Ryan, Denise Macias, Jerry Sonico, Lauren Nathan, Barbara Voigt, Pablo Villablanca, Glen Nyborg, Sergio Godinez, Adele Perrymann, Marian Limacher, Sheila Anderson, Mary Ellen Toombs, Jeffrey Bennett, Kevin Jones, Sandy Brum, Shane Chatfield, Kevin Vantrees, Jennifer Robinson, Candy Wilson, Kevin Koch, Suzette Hart, Jennifer Carroll, Mary Cherrico, Judith Ockene, Linda Churchill, Douglas Fellows, Anthony Serio, Sharon Jackson, Deidre Spavich, Karen Margolis, Cindy Bjerk, Chip Truwitt, Margaret Peitso, Alexa Camcrena, Richard Grim, Julie Levin, Mary Perron, Robert Brunner, Ross Golding, Leslie Pansky, Sandie Arguello, Jane Hammons, Nikki Peterson, Carol Murphy, Maggie Morgan, Mauricio Castillo, Thomas Beckman, Benjamin Huang, Lewis Kuller, Pat McHugh, Carolyn Meltzer, Denise Davis, Joyce Davis, Piera Kost, Kim Lucas, Tom Potter, Lee Tarr, Sally Shumaker, Mark Espeland, Laura Coker, Jeff Williamson, Debbie Felton, LeeAnn Gleiser, Steve Rapp, Claudine Legault, Maggie Dailey, Ramon Casanova, Julia Robertson, Patricia Hogan, Sarah Gaussoin, Pam Nance, Cheryl Summerville, Ricardo Peral, Josh Tan, Nick Bryan, Christos Davatzikos, Lisa Desiderio, Neil Buckholtz, Susan Molchan, Susan Resnick, Jacques Rossouw, Linda Pottern
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27778370/test-retest-repeatability-of-patterns-of-brain-activation-provoked-by-bladder-filling
#14
Becky D Clarkson, Shachi Tyagi, Derek J Griffiths, Neil M Resnick
OBJECTIVE: To assess short-term repeatability of an fMRI protocol widely used to assess brain control of the bladder. fMRI offers the potential to discern incontinence phenotypes as well as the mechanisms mediating therapeutic response. If so, this could enable more targeted efforts to enhance therapy. Such data, however, require excellent test-retest repeatability. METHODS: Fifty-nine older women (age ≥60 years) with urgency incontinence underwent two fMRI scans within 5-10 min with a concurrent bladder infusion/withdrawal protocol...
October 24, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27776986/reliability-and-validity-of-the-resistiveness-to-care-scale-among-cognitively-impaired-older-adults
#15
Elizabeth Galik, Barbara Resnick, Erin Vigne, Sarah Dee Holmes, Victoria Nalls
BACKGROUND: Resistiveness to care is behavior that prevents or interferes with caregivers' performing or assisting with activities of daily living and puts residents at risk for inappropriate use of antipsychotic drugs, other restraining interventions, social isolation, and physical abuse. The purpose of this study was to establish the psychometric properties of a previously developed Resistiveness to Care measure. PROCEDURES: This was a descriptive study using baseline data from an ongoing randomized controlled trial testing a Function and Behavior Focused Care (FBFC) intervention...
October 21, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27769542/clinical-relevance-of-the-routine-daily-chest-x-ray-in-the-surgical-intensive-care-unit
#16
Shelby Resnick, Kenji Inaba, Efstathios Karamanos, Dimitra Skiada, James A Dollahite, Obi Okoye, Peep Talving, Demetrios Demetriades
INTRODUCTION: A daily Chest X-ray (CXR) is obtained in many surgical intensive care units (SICU). This study implemented a selective CXR protocol in a high volume, academic SICU and evaluated its impact on clinical outcomes. METHODS: All SICU patients admitted in 2/2010 were compared with patients admitted in 2/2012. Between the time periods, a protocol eliminating the routine daily CXRs was instituted. RESULTS: In 02/2010 and 02/2012, 107 and 90 patients were admitted to the SICU, respectively, for a total of 1384 patient days...
October 10, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27744302/the-relative-temporal-sequence-of-decline-in-mobility-and-cognition-among-initially-unimpaired-older-adults-results-from-the-baltimore-longitudinal-study-of-aging
#17
Qu Tian, Yang An, Susan M Resnick, Stephanie Studenski
BACKGROUND: most older individuals who experience mobility decline, also show cognitive decline, but whether cognitive decline precedes or follows mobility limitation is not well understood. OBJECTIVE: examine the temporal sequence of mobility and cognition among initially unimpaired older adults. METHODS: mobility and cognition were assessed every 2 years for 6 years in 412 participants aged ≥60 with initially unimpaired cognition and gait speed...
October 15, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27732553/rapid-screening-for-targeted-genetic-variants-via-high-resolution-melting-curve-analysis
#18
Allison B Chambliss, Molly Resnick, Athena K Petrides, William A Clarke, Mark A Marzinke
BACKGROUND: Current methods for the detection of single nucleotide polymorphisms (SNPs) associated with aberrant drug-metabolizing enzyme function are hindered by long turnaround times and specialized techniques and instrumentation. In this study, we describe the development and validation of a high-resolution melting (HRM) curve assay for the rapid screening of variant genotypes for targeted genetic polymorphisms in the cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP3A5. METHODS: Sequence-specific primers were custom-designed to flank nine SNPs within the genetic regions of aforementioned drug metabolizing enzymes...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27721586/implication-of-hypothalamus-in-alleviating-spinal-cord-injury-induced-neuropathic-pain
#19
Andrew D Crowell, Kevin King, Annika Deitermann, Gurwattan S Miranpuri, Daniel K Resnick
Neuropathic pain (NP) is common among spinal cord injury (SCI) patients, and there remain clinical difficulties in treating NP due to the lack of understanding of underlying mechanisms. Extracellular proteins, such as matrix metalloproteinase and β-catenin, have been shown to be activated in the spinal cord regions following an injury, and may play a key role in contributing to NP states. While these extracellular proteins have been used as therapeutic targets in the spinal cord, there has also been evidence of up-regulation in the hypothalamus following a SCI...
September 2016: Annals of Neurosciences
https://www.readbyqxmd.com/read/27697946/estimating-cigarette-tax-avoidance-and-evasion-evidence-from-a-national-sample-of-littered-packs
#20
Dianne C Barker, Shu Wang, David Merriman, Andrew Crosby, Elissa A Resnick, Frank J Chaloupka
INTRODUCTION: A number of recent studies document the proportion of all cigarette packs that are 'contraband' using discarded packs to measure tax avoidance and evasion, which we call tax non-compliance. To date, academic studies using discarded packs focused on relatively small geographical areas such as a city or a neighbourhood. METHODS: We visited 160 communities across 38 US states in 2012 and collected data from littered cigarette packs as part of the State and Community Tobacco Control (SCTC) Research Initiative and the Bridging the Gap Community Obesity Measures Project (BTG-COMP)...
October 2016: Tobacco Control
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