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https://www.readbyqxmd.com/read/28637787/biophysics-and-biofluiddynamics-of-primary-cilia-evidence-for-and-against-the-flow-sensing-function
#1
Subhra Nag, Andrew Resnick
Primary cilia have been called "the forgotten organelle" for over 20 years. As cilia now have their own Journal and several books devoted to their study, perhaps it's time to reconsider the moniker "forgotten organelle". In fact, during the drafting of this review, 12 relevant publications have been issued- we therefore apologize in advance for any relevant work we inadvertently omitted. What purpose is yet another ciliary review? The primary goal of this review is to specifically examine the evidence for and against the hypothesized flow-sensing function of primary cilia expressed by differentiated epithelia within a kidney tubule, bringing together differing disciplines and their respective conceptual and experimental approaches...
June 21, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28633453/a-multifaceted-quality-improvement-strategy-reduces-the-risk-of-catheter-associated-urinary-tract-infection
#2
Cecelia N Theobald, Matthew J Resnick, Thomas Spain, Robert S Dittus, Christianne L Roumie
Objective: Catheter-associated urinary tract infections (CAUTIs) are common and preventable hospital-acquired infections, yet their rate continues to rise nationwide. We describe the implementation of a multifaceted program to reduce catheter use and CAUTI rates while simultaneously addressing barriers to long-term success. Design/Setting/Participants: Pre-post study of medical inpatient veterans between December 2012 and February 2015. Intervention: Five component intervention: (i) a bedside catheter reminder; (ii) multidisciplinary educational campaign; (iii) structured catheter order set with clinical decision support; (iv) automated catheter discontinuation orders; and (v) protocol for post-catheter removal care...
June 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28628587/the-who-what-how-and-why-of-estimating-public-health-activity-spending
#3
Arthur L Sensenig, Beth A Resnick, Jonathon P Leider, David M Bishai
No abstract text is available yet for this article.
June 16, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28625334/remembering-our-geriatric-leaders-of-the-past-and-looking-to-the-future
#4
EDITORIAL
Barbara Resnick
No abstract text is available yet for this article.
May 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28617205/establishing-a-research-agenda-for-understanding-the-role-and-impact-of-mental-health-peer-specialists
#5
Matthew Chinman, D Keith McInnes, Susan Eisen, Marsha Ellison, Marianne Farkas, Moe Armstrong, Sandra G Resnick
Mental health peer specialists are individuals with serious mental illnesses who receive training to use their lived experiences to help others with serious mental illnesses in clinical settings. This Open Forum discusses the state of the research for mental health peer specialists and suggests a research agenda to advance the field. Studies have suggested that peer specialists vary widely in their roles, settings, and theoretical orientations. Theories of action have been proposed, but none have been tested...
June 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28610779/survival-and-complications-following-surgery-and-radiation-for-localized-prostate-cancer-an-international-collaborative-review
#6
REVIEW
Christopher J D Wallis, Adam Glaser, Jim C Hu, Hartwig Huland, Nathan Lawrentschuk, Daniel Moon, Declan G Murphy, Paul L Nguyen, Matthew J Resnick, Robert K Nam
BACKGROUND: Evaluation of treatment options for localized prostate cancer (PCa) remains among the highest priorities for comparative effectiveness research. Surgery and radiotherapy (RT) are the two interventions most commonly used. OBJECTIVE: To provide a critical narrative review of evidence of the comparative effectiveness and harms of surgery and RT in the treatment of localized PCa. EVIDENCE ACQUISITION: A collaborative critical narrative review of the literature was conducted...
June 10, 2017: European Urology
https://www.readbyqxmd.com/read/28609530/cognitive-function-after-testosterone-treatment
#7
LETTER
Susan M Resnick, Alvin M Matsumoto, Alisa J Stephens-Shields
No abstract text is available yet for this article.
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28607815/vertebroplasty-for-vertebral-compression-fractures-placebo-or-effective
#8
EDITORIAL
Arvin R Wali, Joel R Martin, Robert Rennert, Daniel K Resnick, William Taylor, Peter Warnke, Clark C Chen
Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared the use of VP vs. a sham surgery control group. Notably, RCTs comparing nonsurgically treated patients as a control group vs. those undergoing VP uniformly reported that VP contributed to improved pain relief. In contrast, RCTs comparing sham surgery vs...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28605213/computerized-cognitive-testing-norms-in-active-duty-military-personnel-potential-for-contamination-by-psychologically-unhealthy-individuals
#9
Ian Coffman, Helaine E Resnick, James Drane, Corinna E Lathan
Normative reference data used for clinical interpretation of neuropsychological testing results are only valid to the extent that the sample they are based on is composed of "normal" individuals. Accordingly, efforts are made to exclude individuals with histories and/or diagnoses that might bias test performance. In this report, we focus on these features in active-duty military personnel because published data on computerized neurocognitive testing norms for this population have not explicitly considered the consequences of neurobehavioral disorders (e...
June 12, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28600018/current-controversies-in-spinal-and-cranial-surgery
#10
EDITORIAL
Russell R Lonser, Daniel K Resnick
No abstract text is available yet for this article.
July 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28588362/folic-acid-modulates-matrix-metalloproteinase-2-expression-alleviates-neuropathic-pain-and-improves-functional-recovery-in-spinal-cord-injured-rats
#11
Gurwattan S Miranpuri, Sivan Vadakkadath Meethal, Emmanuel Sampene, Abhishek Chopra, Seah Buttar, Carrie Nacht, Neydis Moreno, Kush Patel, Lisa Liu, Anupama Singh, Chandra K Singh, Nithya Hariharan, Bermans Iskandar, Daniel K Resnick
BACKGROUND: The molecular underpinnings of spinal cord injury (SCI) associated with neuropathic pain (NP) are unknown. Recent studies have demonstrated that matrix metalloproteinases (MMPs) such as MMP2 play a critical role in inducing NP following SCI. Promoter methylation of MMPs is known to suppress their transcription and reduce NP. In this context, it has been shown in rodents that folic acid (FA), an FDA approved dietary supplement and key methyl donor in the central nervous system (CNS), increases axonal regeneration and repair of injured CNS in part via methylation...
May 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28561664/data-commons-to-support-pediatric-cancer-research
#12
Samuel L Volchenboum, Suzanne M Cox, Allison Heath, Adam Resnick, Susan L Cohn, Robert Grossman
The falling costs and increasing fidelity of high-throughput biomedical research data have led to a renaissance in cancer surveillance and treatment. Yet, the amount, velocity, and complexity of these data have overcome the capacity of the increasing number of researchers collecting and analyzing this information. By centralizing the data, processing power, and tools, there is a valuable opportunity to share resources and thus increase the efficiency, power, and impact of research. Herein, we describe current data commons and how they operate in the oncology landscape, including an overview of the International Neuroblastoma Risk Group data commons as a paradigm case...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28559842/cross-sectional-and-longitudinal-effects-of-creb1-genotypes-on-individual-differences-in-memory-and-executive-function-findings-from-the-blsa
#13
Claudia Wolf, Yang An, Toshiko Tanaka, Murat Bilgel, Christopher Gonzalez, Melissa Kitner Triolo, Susan Resnick
Purpose: Previously, we have shown that the SNP rs10932201 genotype of the cyclic AMP responsive element binding protein 1 gene (CREB1) contributes to individual differences in executive and memory function at the neural system and behavioral levels in healthy, young adults. However, longitudinal effects of CREB1 genotypes on cognition have not yet been addressed. Furthermore we were interested in replicating associations between CREB1 genotypes and human cognition in previous cross-sectional studies and explore whether APOE...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28552708/recent-changes-in-prostate-cancer-screening-practices-and-prostate-cancer-epidemiology
#14
REVIEW
Daniel J Lee, Katherine Mallin, Amy J Graves, Sam S Chang, David F Penson, Matthew J Resnick, Daniel A Barocas
PURPOSE: Prostate-specific antigen (PSA) based screening for prostate cancer has had a significant impact on the epidemiology of the disease. Its use has been associated with a significant reduction in prostate cancer mortality, but has also resulted in the overdiagnosis and overtreatment of indolent prostate cancer, exposing many men to the harms of treatment without benefit. The U.S. Preventive Service Task Force (USPSTF) issued a recommendation against screening men over 75 in 2008, and against routine screening for all men in 2012, indicating that, in their interpretation, the harms of screening outweigh the benefits...
May 25, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28521632/hepatic-calcified-tumor-like-mass-complicating-umbilical-vein-catheterization-in-a-neonate
#15
Jeffrey M Resnick, Brett Carmichael, Audra Winder, Kathleen M Dominguez
Presented is a case of a hepatic calcified mass complicating umbilical vein catheterization in a neonate and diagnosed by wedge biopsy. Wedge biopsy of the hepatic mass, situated in proximity to the falciform ligament, revealed expansion of portal tracts by fibrosis and calcification. Some aggregates of calcified material appeared in ectatic vascular spaces. The biopsy findings accounted for the radiographic appearance of the mass and the constellation of features were deemed indicative of calcification secondary to umbilical vein catheterization...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28502241/competitive-employment-outcomes-among-veterans-in-vha-therapeutic-and-supported-employment-services-programs
#16
Kristen M Abraham, Matheos Yosef, Sandra G Resnick, Kara Zivin
OBJECTIVE: The study assessed whether receiving specific types of Veterans Health Administration (VHA) Therapeutic and Supported Employment Services (TSES) between fiscal years (FYs) 2006 and 2010 (a time frame that encompasses the Great Recession) was associated with obtaining competitive employment among veterans with mental illnesses. METHODS: The sample included 38,199 veterans discharged from the VHA's TSES program in FY 2006 through FY 2010. On the basis of program monitoring forms completed by TSES clinicians and workload data, veterans were classified as having received one main type of employment service: supported employment (SE), transitional work in the community (TW-community), transitional work in a Department of Veterans Affairs medical center (TW-VA), incentive therapy or sheltered workshop (IT/SW), and no main type of employment service...
May 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28495746/restored-iron-transport-by-a-small-molecule-promotes-absorption-and-hemoglobinization-in-animals
#17
Anthony S Grillo, Anna M SantaMaria, Martin D Kafina, Alexander G Cioffi, Nicholas C Huston, Murui Han, Young Ah Seo, Yvette Y Yien, Christopher Nardone, Archita V Menon, James Fan, Dillon C Svoboda, Jacob B Anderson, John D Hong, Bruno G Nicolau, Kiran Subedi, Andrew A Gewirth, Marianne Wessling-Resnick, Jonghan Kim, Barry H Paw, Martin D Burke
Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes. Here we report that a small-molecule natural product, hinokitiol, can harness such gradients to restore iron transport into, within, and/or out of cells. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient zebrafish...
May 12, 2017: Science
https://www.readbyqxmd.com/read/28494414/relationship-violence-victimization-and-binge-drinking-trajectories-among-a-nationally-representative-sample-of-adolescents
#18
Kate Walsh, Angela M Moreland, Rochelle F Hanson, Heidi S Resnick, Benjamin E Saunders, Dean G Kilpatrick
The present study evaluated the impact of relationship violence (RV) victimization on the longitudinal trajectory of binge drinking (BD) among 3614 US adolescents (51.2% male) who participated in an initial telephone interview regarding physical and sexual RV victimization and binge drinking. Two follow-up phone interviews were completed over approximately three years. Multilevel modeling revealed small, but significant, increases in BD over time; older adolescents and those who had ever experienced RV victimization were more likely to report BD at Wave 1 compared to younger adolescents and non-victims...
May 8, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28492251/multi-phase-volcanic-resurfacing-at-loki-patera-on-io
#19
K de Kleer, M Skrutskie, J Leisenring, A G Davies, A Conrad, I de Pater, A Resnick, V Bailey, D Defrère, P Hinz, A Skemer, E Spalding, A Vaz, C Veillet, C E Woodward
The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21,500 square kilometres surrounding a much cooler central 'island'. The temperature gradient seen across areas of the patera indicates a systematic resurfacing process, which has been seen to occur typically every one to three years since the 1980s. Analysis of past data has indicated that the resurfacing progressed around the patera in an anti-clockwise direction at a rate of one to two kilometres per day, and that it is caused either by episodic eruptions that emplace voluminous lava flows or by a cyclically overturning lava lake contained within the patera...
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28483946/p53-maintains-baseline-expression-of-multiple-tumor-suppressor-genes
#20
Kyrie Pappas, Jia Xu, Sakellarios Zairis, Lois Resnick-Silverman, Francesco Abate, Nicole Steinbach, Sait Ozturk, Lao H Saal, Tao Su, Pamela Cheung, Hank Schmidt, Stuart A Aaronson, Hanina Hibshoosh, James J Manfredi, Raul Rabadan, Ramon Parsons
TP53 is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters. Depletion of p53 reduced expression of these target genes, and analysis across 18 tumor types showed that mutation of TP53 associated with reduced expression of many of these genes...
May 8, 2017: Molecular Cancer Research: MCR
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