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https://www.readbyqxmd.com/read/28812459/alox15-immunohistochemistry-aids-in-the-diagnosis-of-eosinophilic-esophagitis-on-pauci-eosinophilic-biopsies-in-children
#1
Yiang Hui, Sonja Chen, Kara A Lombardo, Murray B Resnick, Shamlal Mangray, Andres Matoso
Histologically, esophageal biopsies should have ≥15 intraepithelial eosinophils (IEEs) per high power field (HPF) to support a clinicopathologic diagnosis of eosinophilic esophagitis (EoE). Children with clinically apparent EoE may show pauci-eosinophilic biopsies due to patchy involvement. Immunostaining (Immunohistochemistry) for arachidonate-15 lipooxygenase (ALOX15) has been demonstrated to be a sensitive marker for EoE. We retrospectively assessed the expression of ALOX15 in 48 biopsies from 21 patients with established diagnosis of EoE and with tissue fragments below the threshold of 15 IEEs/HPF...
September 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28806397/mdm2-promotes-cdc25c-protein-degradation-and-delays-cell-cycle-progression-through-the-g2-m-phase
#2
L E Giono, L Resnick-Silverman, L A Carvajal, S St Clair, J J Manfredi
Upon different types of stress, the gene encoding the mitosis-promoting phosphatase Cdc25C is transcriptionally repressed by p53, contributing to p53's enforcement of a G2 cell cycle arrest. In addition, Cdc25C protein stability is also decreased following DNA damage. Mdm2, another p53 target gene, encodes a ubiquitin ligase that negatively regulates p53 levels by ubiquitination. Ablation of Mdm2 by siRNA led to an increase in p53 protein and repression of Cdc25C gene expression. However, Cdc25C protein levels were actually increased following Mdm2 depletion...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28806393/craf-gene-fusions-in-pediatric-low-grade-gliomas-define-a-distinct-drug-response-based-on-dimerization-profiles
#3
P Jain, T M Fierst, H J Han, T E Smith, A Vakil, P J Storm, A C Resnick, A J Waanders
Pediatric low-grade gliomas (PLGGs) are commonly associated with BRAF gene fusions that aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway. This has led to PLGG clinical trials utilizing RAF- and MAPK pathway-targeted therapeutics. Whole-genome profiling of PLGGs has also identified rare gene fusions involving another RAF isoform, CRAF/RAF1, in PLGGs and cancers occuring in adults. Whereas BRAF fusions primarily dysregulate MAPK signaling, the CRAF fusions QKI-RAF1 and SRGAP3-RAF1 aberrantly activate both the MAPK and phosphoinositide-3 kinase/mammalian target of rapamycin (PI3K/mTOR) signaling pathways...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28805015/stromelysin-2-mmp-10-a-novel-mediator-of-vascular-remodeling-underlying-pulmonary-hypertension-associated-with-systemic-sclerosis
#4
Jérôme Avouac, Christophe Guignabert, Anna Maria Hoffmann-Vold, Barbara Ruiz, Peter Dorfmuller, Sonia Pezet, Olivia Amar, Ly Tu, Jérôme Van Wassenhove, Jérémy Sadoine, David Launay, Muriel Elhai, Anne Cauvet, Arun Subramaniam, Robert Resnick, Eric Hachulla, Øyvind Molberg, André Kahan, Marc Humbert, Yannick Allanore
OBJECTIVE: To decipher the role of gene candidates involved in pulmonary hypertension (PH) associated with systemic sclerosis (SSc). METHODS: Gene candidates were identified through microarray experiments performed on Affymetrix GeneChip(®) Human Exon 1.0 ST Arrays in endothelial progenitor cell (EPC)-derived endothelial cells (ECs) issued from patients with SSc-PH, SSc without PH and controls. Expression of identified candidates was assessed by quantitative sandwich ELISA in the serum and by immunohistochemistry in lesional lung tissue...
August 13, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28782542/supported-employment-for-veterans-with-traumatic-brain-injury-patient-perspectives
#5
Kathleen F Carlson, Terri K Pogoda, Tess Gilbert, Sandra G Resnick, Elizabeth Twamley, Maya E O'Neil, Nina A Sayer
OBJECTIVE: To quantify the need for, and interest in, Supported Employment (SE) among recent military Veterans with traumatic brain injury (TBI), and to examine characteristics associated with Veterans' interest in SE. DESIGN: Stratified random sample of Iraq and Afghanistan War Veterans confirmed to have TBI through the Veterans Health Administration (VHA) screening and evaluation system. SETTING: Community-based via mailed survey. PARTICIPANTS: We recruited 1,800 Veterans with clinician-confirmed TBI (1,080 mild TBI; 720 moderate/severe TBI) through multiple mailings...
August 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28780023/shared-acvr1-mutations-in-fop-and-dipg-opportunities-and-challenges-in-extending-biological-and-clinical-implications-across-rare-diseases
#6
Harry J Han, Payal Jain, Adam C Resnick
Gain-of-function mutations in the Type I Bone Morphogenic Protein (BMP) receptor ACVR1 have been identified in two diseases: Fibrodysplasia Ossificans Progressiva (FOP), a rare autosomal dominant disorder characterized by genetically driven heterotopic ossification, and in 20-25% of Diffuse Intrinsic Pontine Gliomas (DIPGs), a pediatric brain tumor with no effective therapies and dismal median survival. While the ACVR1 mutation is causal for FOP, its role in DIPG tumor biology remains under active investigation...
August 2, 2017: Bone
https://www.readbyqxmd.com/read/28740786/virtual-surgical-planning-for-mandibular-distraction-in-infants-with-robin-sequence
#7
Cory M Resnick
Mandibular distraction osteogenesis (MDO) successfully relieves obstructive sleep apnea in many infants with Robin sequence. Preoperative virtual surgical planning and fabrication of three-dimensionally printed cutting guides may lead to further improvements in the MDO technique and decrease the risk for damage to adjacent structures such as developing teeth and the inferior alveolar nerve. This report presents an algorithm for virtual surgical planning and three-dimensionally printing of cutting guides for MDO in infants with RS...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28731452/temporal-order-of-alzheimer-s-disease-related-cognitive-marker-changes-in-blsa-and-wrap-longitudinal-studies
#8
Murat Bilgel, Rebecca L Koscik, Yang An, Jerry L Prince, Susan M Resnick, Sterling C Johnson, Bruno M Jedynak
Investigation of the temporal trajectories of currently used neuropsychological tests is critical to identifying earliest changing measures on the path to dementia due to Alzheimer's disease (AD). We used the Progression Score (PS) method to characterize the temporal trajectories of measures of verbal memory, executive function, attention, processing speed, language, and mental status using data spanning normal cognition, mild cognitive impairment, and AD from 1,661 participants with a total of 7,839 visits (age at last visit 77...
July 18, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28718441/is-intra-articular-steroid-injection-to-the-temporomandibular-joint-for-juvenile-idiopathic-arthritis-more-effective-and-efficient-when-performed-with-image-guidance
#9
Cory M Resnick, Pouya M Vakilian, Leonard B Kaban, Zachary S Peacock
PURPOSE: To compare short-term outcomes and procedure times for intra-articular steroid injection (IASI) to the temporomandibular joint (TMJ) with and without the use of intraoperative image guidance for patients with juvenile idiopathic arthritis (JIA). MATERIALS AND METHODS: This is a retrospective study of children with JIA who underwent TMJ IASI at Boston Children's Hospital (Boston, MA). Patients were divided into groups according to IASI technique: 1) "landmark" group if performed by an oral and maxillofacial surgeon using an anatomic landmark technique with no intraoperative image guidance or 2) "image-guided" group if performed by an interventional radiologist using intraoperative ultrasound and computed tomography...
April 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28702496/nasal-septal-and-mucosal-disease-associated-with-pyoderma-gangrenosum-in-a-cocaine-user
#10
Rahul Sehgal, Jeffrey M Resnick, Ali Al-Hilli, Namrata Mehta, Tyler Conway, Erik J Stratman
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28700413/venous-thromboembolism-after-major-venous-injuries-competing-priorities
#11
Brian Frank, Zoё Maher, Joshua P Hazelton, Shelby Resnick, Elizabeth Dauer, Anna Goldenberg, Andrea L Lubitz, Brian P Smith, Noelle N Saillant, Patrick M Reilly, Mark J Seamon
BACKGROUND: Venous thromboembolism (VTE) after major vascular injury (MVI) is particularly challenging as the competing risk of thrombosis and embolization after direct vessel injury must be balanced with risk of bleeding after surgical repair. We hypothesized that venous injuries, repair type and intraoperative anticoagulation would influence VTE formation after MVI. METHODS: A multi-institution, retrospective cohort study of consecutive MVI patients was conducted at 3 urban, level-I centers (2005-2013)...
July 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28689466/early-diagnosis-and-treatment-of-lennox-gastaut-syndrome
#12
Trevor Resnick, Raj D Sheth
Lennox-Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy associated with high morbidity and mortality. The peak period for manifestations of Lennox-Gastaut syndrome is between ages 3 and 5 years, a time of critical brain development and corresponding vulnerability to the electroclinical dysfunction arising from Lennox-Gastaut syndrome. Diagnosis is based on a triad of symptoms: multiple seizure types, cognitive impairment, and slow spike-and-wave pattern on electroencephalography. In practice, Lennox-Gastaut syndrome presentation is diverse, and there may be a delay between initial symptoms and emergence of the full triad of clinical features...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28687369/corrigendum-to-exemplars-in-advanced-practice-gerontological-nursing-a-gapna-series-gapna-consensus-statement-proficiency-9-geriatr-nurs-38-2-2017-165-167
#13
Elizabeth Galik, Barbara Resnick
No abstract text is available yet for this article.
July 4, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28668951/the-relationship-between-age-common-bile-duct-diameter-and-diagnostic-probability-in-suspected-choledocholithiasis
#14
Efstathios Karamanos, Kenji Inaba, Regan J Berg, Shelby Resnick, Obi Okoye, Sophoclis Alexopoulos, Konstantinos Chouliaras, Demetrios Demetriades
BACKGROUND: Aging has been associated with increasing common bile duct (CBD) diameter and reported as independently predictive of the likelihood of choledocolithiasis. These associations are controversial with uncertain diagnostic utility in patients presenting with symptomatic disease. The current study examined the relationship between age, CBD size, and the diagnostic probability of choledocolithiasis. METHODS: Symptomatic patients undergoing evaluation for suspected choledocolithiasis from January 2008 to February 2011 were reviewed...
July 1, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28668154/mr-imaging-of-the-female-perineum-clitoris-labia-and-introitus
#15
REVIEW
Monica D Agarwal, Elena L Resnick, Jennifer Ni Mhuircheartaigh, Koenraad J Mortele
The female perineum has a complex anatomy and can be involved by a wide range of pathologies. In this article, we specifically focus on the clitoris, labia, and introitus. We discuss the normal anatomy of these structures, the MR imaging techniques to optimize their evaluation, and several common and uncommon entities that may affect them, including benign and malignant tumors, as well as infectious and inflammatory, vascular, iatrogenic, and developmental entities.
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28666927/prognostic-significance-of-igg4-plasma-cell-infiltrates-following-neoadjuvant-chemoradiation-therapy-for-esophageal-adenocarcinoma
#16
Evgeny Yakirevich, Shaolei Lu, Danisha Allen, Shamlal Mangray, Jacqueline R Fanion, Kara A Lombardo, Howard Safran, Murray B Resnick
Lymphoplasmacytic infiltrates in esophageal adenocarcinoma (EAC) tissue following chemoradiotherapy (CRT) reflect alterations in the tumor immunoenvironment. The presence and role of plasma cells in this process are poorly understood. Our aim was to characterize the IgG4+ plasma cell population in EAC following CRT. Seventy-one esophagectomy specimens post CRT were compared to a surgery only group of 31 EACs. The distribution, density, and ratio of IgG4+ and IgG+ plasma cells were evaluated by immunohistochemistry and correlated with clinicopathologic features, treatment response, and survival...
June 27, 2017: Human Pathology
https://www.readbyqxmd.com/read/28657951/firearm-deaths-in-america-can-we-learn-from-462-000-lives-lost
#17
Shelby Resnick, Randi N Smith, Jessica H Beard, Daniel Holena, Patrick M Reilly, C William Schwab, Mark J Seamon
OBJECTIVE: We sought to determine whether state firearm legislation correlated with firearm-related fatality rates (FFR) during a 15-year period. BACKGROUND: The politicized and controversial topic of firearm legislation has been grossly understudied when the relative impact of American firearm violence is considered. Scientific evidence regarding gun legislation effectiveness remains scant. METHODS: Demographic and intent data (1999-2013) were collected from the Centers for Disease Control and Prevention's Web-Based Injury Statistics Query and Reporting System database and compared by state firearm legislation rankings with respect to FFR...
June 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28655530/variation-in-the-diagnostic-evaluation-among-persons-with-hematuria-influence-of-gender-race-and-risk-factors-for-bladder-cancer
#18
Jacob T Ark, JoAnn R Alvarez, Tatsuki Koyama, Jeffrey C Bassett, William J Blot, Michael T Mumma, Matthew J Resnick, Chaochen You, David F Penson, Daniel A Barocas
PURPOSE: To determine whether race, gender, and number of bladder cancer risk factors are significant predictors of hematuria evaluation. METHODS: We used self-reported data from the Southern Community Cohort Study linked to Medicare claims data. Evaluation of subjects diagnosed with incident hematuria was considered complete if both imaging and cystoscopy were performed within 180 days of diagnosis. Exposures of interest were race, gender, and risk factors for bladder cancer...
June 24, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28653035/a-classification-algorithm-for-predicting-progression-from-normal-cognition-to-mild-cognitive-impairment-across-five-cohorts-the-preclinical-ad-consortium
#19
Alden L Gross, Jason J Hassenstab, Sterling C Johnson, Lindsay R Clark, Susan M Resnick, Melissa Kitner-Triolo, Colin L Masters, Paul Maruff, John C Morris, Anja Soldan, Corinne Pettigrew, Marilyn S Albert
INTRODUCTION: We established a method for diagnostic harmonization across multiple studies of preclinical Alzheimer's disease and validated the method by examining its relationship with clinical status and cognition. METHODS: Cognitive and clinical data were used from five studies (N = 1746). Consensus diagnoses established in each study used criteria to identify progressors from normal cognition to mild cognitive impairment. Correspondence was evaluated between these consensus diagnoses and three algorithmic classifications based on (1) objective cognitive impairment in 2+ tests only; (2) a Clinical Dementia Rating (CDR) of ≥0...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28637787/biophysics-and-biofluiddynamics-of-primary-cilia-evidence-for-and-against-the-flow-sensing-function
#20
Subhra Nag, Andrew Resnick
Primary cilia have been called "the forgotten organelle" for over 20 years. As cilia now have their own Journal and several books devoted to their study, perhaps it's time to reconsider the moniker "forgotten organelle". In fact, during the drafting of this review, 12 relevant publications have been issued- we therefore apologize in advance for any relevant work we inadvertently omitted. What purpose is yet another ciliary review? The primary goal of this review is to specifically examine the evidence for and against the hypothesized flow-sensing function of primary cilia expressed by differentiated epithelia within a kidney tubule, bringing together differing disciplines and their respective conceptual and experimental approaches...
June 21, 2017: American Journal of Physiology. Renal Physiology
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