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https://www.readbyqxmd.com/read/29783578/re-association-of-robotic-assisted-vs-laparoscopic-radical-nephrectomy-with-perioperative-outcomes-and-health-care-costs-2003-to-2015
#1
Matthew J Resnick
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29783577/re-high-deductible-health-plans-reduce-health-care-cost-and-utilization-including-use-of-needed-preventive-services
#2
Matthew J Resnick
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29783576/re-wide-variation-and-overprescription-of-opioids-after-elective-surgery
#3
Matthew J Resnick
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29783574/re-the-cumulative-burden-of-surviving-childhood-cancer-an-initial-report-from-the-st-jude-lifetime-cohort-study-sjlife
#4
Matthew J Resnick
No abstract text is available yet for this article.
June 2018: Journal of Urology
https://www.readbyqxmd.com/read/29771847/review-of-surgeon-participation-in-early-accountable-care-organizations-by-resnick-mj-graves-aj-buntin-mb-richards-mr-penson-df-in-ann-surg-267-401-407-2018
#5
Venkata S Kothamasu, Larry H Hollier
No abstract text is available yet for this article.
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29763623/molecular-pathological-radiological-and-immune-profiling-of-non-brainstem-pediatric-high-grade-glioma-from-the-herby-phase-ii-randomized-trial
#6
Alan Mackay, Anna Burford, Valeria Molinari, David T W Jones, Elisa Izquierdo, Jurriaan Brouwer-Visser, Felice Giangaspero, Christine Haberler, Torsten Pietsch, Thomas S Jacques, Dominique Figarella-Branger, Daniel Rodriguez, Paul S Morgan, Pichai Raman, Angela J Waanders, Adam C Resnick, Maura Massimino, Maria Luisa Garrè, Helen Smith, David Capper, Stefan M Pfister, Thomas Würdinger, Rachel Tam, Josep Garcia, Meghna Das Thakur, Gilles Vassal, Jacques Grill, Tim Jaspan, Pascale Varlet, Chris Jones
The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE/POLD1 mutations) and those biologically resembling pleomorphic xanthoastrocytoma ([PXA]-like, driven by BRAF_V600E or NF1 mutation) had significantly more CD8+ tumor-infiltrating lymphocytes, and longer survival with the addition of BEV...
May 14, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29760046/dual-hdac-and-pi3k-inhibition-abrogates-nf%C3%AE%C2%BAb-and-foxm1-mediated-dna-damage-response-to-radiosensitize-pediatric-high-grade-gliomas
#7
Sharmistha Pal, David Kozono, Xiaodong Yang, Wojciech Fendler, Whitney Fitts, Jing Ni, John A Alberta, Jean Zhao, Kevin X Liu, Jie Bian, Nathalene Truffaux, William A Weiss, Adam C Resnick, Pratiti Bandopadhayay, Keith L Ligon, Steven G Dubois, Sabine Mueller, Dipanjan Chowdhury, Daphne A Haas-Kogan
Aberrant chromatin remodeling and activation of the phosphatidylinositol 3-kinase (PI3K) pathway have been identified as important mediators of pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) pathogenesis. As inhibition of these pathways are promising therapeutic avenues and radiation is the only modality to prolong survival of DIPG patients, we sought to explore radiosensitizing functions of such inhibition and explore mechanisms of action of such agents. Here we demonstrate that combined treatment with radiotherapy and CUDC-907, a novel first-in-class dual inhibitor of histone deacetylases (HDAC) and PI3K, evokes a potent cytotoxic response in pHGG and DIPG models...
May 14, 2018: Cancer Research
https://www.readbyqxmd.com/read/29759809/what-will-you-put-in-your-shadow-memory-box
#8
EDITORIAL
Barbara Resnick
No abstract text is available yet for this article.
May 11, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29745717/factors-contributing-to-the-effective-functioning-of-veterans-mental-health-councils
#9
Sarah Beehler, Sarah A Marsella, Peggy M Henderson, Sandra G Resnick, Mark Meterko
Veterans Mental Health Councils (VMHCs) have been established at many Veterans Affairs (VA) medical centers to promote recovery and improve mental health services. Though research shows that consumer-led advisory councils may produce a number of positive outcomes, the aspects of implementation critical for VMHC effectiveness have not been identified. The purpose of this study was to identify factors influencing effective functioning of VMHC, including contextual factors affecting council success. A key goal was to understand how participants defined effective council functioning...
May 10, 2018: Psychological Services
https://www.readbyqxmd.com/read/29741590/rate-of-muscle-contraction-is-associated-with-cognition-in-women-not-in-men
#10
Qu Tian, Yusuke Osawa, Susan M Resnick, Luigi Ferrucci, Stephanie A Studenski
Background: In older persons, lower hand grip strength is associated with poorer cognition. Little is known about how the rate of muscle contraction relates to cognition and upper extremity motor function, and sex differences are understudied. Methods: Linear regression, adjusting for age, race, education, body mass index, appendicular lean mass, and knee pain assessed sex-specific cross-sectional associations of peak torque, rate of torque development (RTD) and rate of velocity development (RVD) with cognition and upper extremity motor function...
May 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29733669/suicidal-ideation-among-adolescents-following-natural-disaster-the-role-of-prior-interpersonal-violence
#11
Kelly L Zuromski, Heidi Resnick, Matthew Price, Sandro Galea, Dean G Kilpatrick, Kenneth Ruggiero
OBJECTIVE: The current study examined variables, including prior traumatic events, disaster exposure, and current mental health symptomatology, associated with suicidal ideation following experience of a natural disaster. METHOD: Utilizing a sample of 2,000 adolescents exposed to the spring 2011 tornadoes in the areas surrounding Tuscaloosa, Alabama, and Joplin, Missouri, we hypothesized that prior interpersonal violence (IPV), more so than other prior traumatic events or other symptoms, would be associated with suicidal ideation after the disaster...
May 7, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29732554/understanding-health-related-quality-of-life-in-adult-women-with-metastatic-cancer-who-have-dependent-children
#12
Eliza M Park, Allison M Deal, Justin M Yopp, Teresa Edwards, Samuel J Resnick, Mi-Kyung Song, Zev M Nakamura, Donald L Rosenstein
BACKGROUND: Cancer is a leading cause of death among women of parenting age in the United States. Women living with advanced or incurable cancer who have dependent children experience high rates of depression and anxiety as well as unique parenting challenges. To the authors' knowledge, few studies to date have examined the parenting factors associated with health-related quality of life (HRQOL) in women with advanced cancer. METHODS: The authors conducted a cross-sectional, Web-based survey of the psychosocial concerns of 224 women with a tumor-node-metastasis staging system of the AJCC stage IV solid tumor malignancy who had at least 1 child aged <18 years...
May 6, 2018: Cancer
https://www.readbyqxmd.com/read/29728519/first-in-human-pet-study-of-3-novel-tau-radiopharmaceuticals-11-c-ro6924963-11-c-ro6931643-and-18-f-ro6958948
#13
Dean F Wong, Robert Comley, Hiroto Kuwabara, Paul B Rosenberg, Susan M Resnick, Susanne Ostrowitzki, Cristina Vozzi, Frank Boess, Esther Oh, Constantine G Lyketsos, Michael Honer, Luca Gobbi, Gregory Klein, Noble George, Lorena Gapasin, Kelly Kitzmiller, Joshua Roberts, Jeff Sevigny, Ayon Nandi, James R Brasic, Chakradhar Mishra, Madhav Thambisetty, Abhay Moghekar, Anil Mathur, Marilyn Albert, Robert F Dannals, Edilio Borroni
Background: [11 C]RO-963, [11 C]RO-643 and [18 F]RO-948 (previously referred as [11 C]RO6924963, [11 C]RO6931643, and [18 F]RO6958948, respectively) have been reported as promising PET tracers for tau imaging based on in vitro and preclinical PET data (1,2). Here we describe the first human evaluation of these novel radiotracers. Methods: Amyloid PET positive Alzheimer's disease (AD) patients and young healthy subjects (YC) each received two different tau tracers. Dynamic 90 min scans were obtained after bolus injection of [11 C]RO-963, [11 C]RO-643 or [18 F]RO-948...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29718206/facioscapulohumeral-dystrophy-activating-an-early-embryonic-transcriptional-program-in-human-skeletal-muscle
#14
Amy E Campbell, Andrea Belleville, Rebecca Resnick, Sean C Shadle, Stephen J Tapscott
Facioscapulohumeral dystrophy (FSHD) is the third most prevalent muscular dystrophy. A progressive disease, it presents clinically as weakness and wasting of the face, shoulder, and upper arm muscles, with later involvement of the trunk and lower extremities. FSHD develops through complex genetic and epigenetic events that converge on a common mechanism of toxicity with mis-expression of the transcription factor double homeobox 4 (DUX4). There is currently no treatment available for FSHD. However, the consensus that ectopic DUX4 expression in skeletal muscle is the root cause of FSHD pathophysiology has allowed research efforts to turn towards cultivating a deeper understanding of DUX4 biology and the pathways that underlie FSHD muscle pathology, and to translational studies aimed at developing targeted therapeutics using ever more sophisticated cell and animal-based models of FSHD...
April 28, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29704926/language-as-an-application-of-mindfulness
#15
EDITORIAL
Sheryl Zimmerman, Paul R Katz, Philip D Sloane, Malaz Boustani, Mallory Brown, Matteo Cesari, Gustavo Duque, Kathryn Hyer, Francesco Landi, David Nace, Barbara Resnick, Martin Smalbrugge, David A Smith, Karl E Steinberg, Ladislav Volicer, Gregg Warshaw, Heidi K White
No abstract text is available yet for this article.
May 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29697473/we-do-not-know-what-we-do-not-know-innovative-approaches-to-value-measurement
#16
Aaron A Laviana, Matthew J Resnick
PURPOSE OF REVIEW: Over the past several years, there has been an increasing focus on improving the 'value' of healthcare delivered, defined as the ratio of clinical outcomes to the costs incurred to achieve them. The former U.S. Secretary of Health and Human Services Sylvia Burwell announced in 2015 that the majority of healthcare payments in the Medicare and Medicaid programmes will align with value by 2018. Although this has yet to fully mature, numerous health systems have restructured with a goal of improving the value of care delivered to their populations...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29685658/novel-founder-intronic-variant-in-slc39a14-in-two-families-causing-manganism-and-potential-treatment-strategies
#17
Lance H Rodan, Marissa Hauptman, Alissa M D'Gama, Anita E Qualls, Siqi Cao, Karin Tuschl, Fatma Al-Jasmi, Jozef Hertecant, Susan J Hayflick, Marianne Wessling-Resnick, Edward T Yang, Gerard T Berry, Andrea Gropman, Alan D Woolf, Pankaj B Agrawal
Congenital disorders of manganese metabolism are rare occurrences in children, and medical management of these disorders is complex and challenging. Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. We performed whole exome sequencing on DNA samples from two unrelated female children from the United Arab Emirates with progressive movement disorder and brain mineralization, identified a novel homozygous intronic mutation in SLC39A14 in both children, and demonstrated that the mutation leads to aberrant splicing...
April 6, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29679574/evidence-of-demyelination-in-mild-cognitive-impairment-and-dementia-using-a-direct-and-specific-magnetic-resonance-imaging-measure-of-myelin-content
#18
Mustapha Bouhrara, David A Reiter, Christopher M Bergeron, Linda M Zukley, Luigi Ferrucci, Susan M Resnick, Richard G Spencer
INTRODUCTION: We investigated brain demyelination in aging, mild cognitive impairment (MCI), and dementia using magnetic resonance imaging of myelin. METHODS: Brains of young and old controls and old subjects with MCI, Alzheimer's disease, or vascular dementia were scanned using our recently developed myelin water fraction (MWF) mapping technique, which provides greatly improved accuracy over previous comparable methods. Maps of MWF, a direct and specific myelin measure, and relaxation times and magnetization transfer ratio, indirect and nonspecific measures, were constructed...
April 18, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29677887/re-association-between-use-of-antithrombotic-medication-and-hematuria-related-complications
#19
Matthew J Resnick
No abstract text is available yet for this article.
May 2018: Journal of Urology
https://www.readbyqxmd.com/read/29677886/re-comparing-the-effects-of-reference-pricing-and-centers-of-excellence-approaches-to-value-based-benefit-design
#20
Matthew J Resnick
No abstract text is available yet for this article.
May 2018: Journal of Urology
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