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https://www.readbyqxmd.com/read/29140749/pharmacists-as-vaccinators-an-analysis-of-their-experiences-and-perceptions-of-their-new-role
#1
Sandra Gerges, Elizabeth Peter, Susan K Bowles, Shelley Diamond, Lucie Marisa Bucci, Anne Resnick, Anna Taddio
OBJECTIVES: In 2012, Ontario pharmacists were granted immunization privileges to administer influenza vaccines to the public. This study explored the experiences and practices of pharmacist vaccinators and the impact of vaccination pain on their practice. METHODS: Semi-structured interviews were conducted with 12 pharmacists in the Greater Toronto Area. Transcribed interview data were coded and analyzed via thematic analysis. KEY FINDINGS: Data analysis revealed 4 main themes: 1) expanded scope of practice as an enhancement and challenge to relationships; 2) professional satisfaction and workload demands; 3) knowledge and attitudes regarding pain and fear; 4) practices regarding pain and fear management...
November 15, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29128280/geriatric-nursing-and-resilience-in-the-midst-of-tropical-storm-harvey
#2
EDITORIAL
Barbara Resnick
No abstract text is available yet for this article.
November 8, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29128207/safeguarding-the-future-of-urological-research-and-delivery-of-clinical-excellence-by-harnessing-the-power-of-youth-to-spearhead-urological-research
#3
EDITORIAL
Veeru Kasivisvanathan, Alexander Kutikov, Todd G Manning, John McGrath, Matthew J Resnick, J P Michiel Sedelaar, Mesrur S Silay
Trainee-led collaboratives offer exciting new perspectives and approaches to urological research. They provide a central network of expertise in methodology, mentoring, and knowledge of research processes that allows the conduct of large multicentre studies that can recruit quickly. This provides the consultant workforce of tomorrow with the skills required to deliver practice-changing clinical studies in urology.
November 8, 2017: European Urology
https://www.readbyqxmd.com/read/29125932/pathogenesis-of-cleft-palate-in-robin-sequence-observations-from-prenatal-magnetic-resonance-imaging
#4
Cory M Resnick, Judy A Estroff, Tessa D Kooiman, Carly E Calabrese, Maarten J Koudstaal, Bonnie L Padwa
PURPOSE: The etiology of the palatal cleft in Robin sequence (RS) is unknown. The purpose of this study was to assess the position of the fetal tongue at prenatal magnetic resonance imaging (MRI) and to suggest a potential relation between tongue position and development of the cleft palate seen in most patients with RS. MATERIALS AND METHODS: This is a retrospective case-and-control study including fetuses with prenatal MRIs performed in the authors' center from 2002 to 2017...
October 16, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29116990/factors-influencing-job-satisfaction-among-long-term-care-staff
#5
Kelly Doran, Barbara Resnick, Jennifer Swanberg
OBJECTIVE: We assessed the intrapersonal, interpersonal, and organizational factors that predicted job satisfaction among long-term care employees. METHODS: Baseline data were used to describe characteristics that influence job satisfaction. Using a forced linear regression model, while controlling for age and job title, we assessed if higher physical activity levels, fewer symptoms of depression, stress, and/or anxiety (ie, decreased mood), less back pain, stronger social support, and reports of low work demands were associated with higher job satisfaction...
November 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29107121/longitudinally-and-inter-site-consistent-multi-atlas-based-parcellation-of-brain-anatomy-using-harmonized-atlases
#6
Guray Erus, Jimit Doshi, Yang An, Dimitris Verganelakis, Susan M Resnick, Christos Davatzikos
As longitudinal and multi-site studies become increasingly frequent in neuroimaging, maintaining longitudinal and inter-scanner consistency of brain parcellation has become a major challenge due to variation in scanner models and/or image acquisition protocols across scanners and sites. We present a new automated segmentation method specifically designed to achieve a consistent parcellation of anatomical brain structures in such heterogeneous datasets. Our method combines a site-specific atlas creation strategy with a state-of-the-art multi-atlas anatomical label fusion framework...
November 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29070548/excess-iron-considerations-related-to-development-and-early-growth
#7
REVIEW
Marianne Wessling-Resnick
What effects might arise from early life exposures to high iron? This review considers the specific effects of high iron on the brain, stem cells, and the process of erythropoiesis and identifies gaps in our knowledge of what molecular damage may be incurred by oxidative stress that is imparted by high iron status in early life. Specific areas to enhance research on this topic include the following: longitudinal behavioral studies of children to test associations between iron exposures and mood, emotion, cognition, and memory; animal studies to determine epigenetic changes that reprogram brain development and metabolic changes in early life that could be followed through the life course; and the establishment of human epigenetic markers of iron exposures and oxidative stress that could be monitored for early origins of adult chronic diseases...
October 25, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29062883/high-dose-chemotherapy-and-stem-cell-rescue-for-salvage-therapy-for-relapsed-malignant-mixed-ovarian-germ-cell-tumor-a-case-report
#8
Sarah Sears, Sareena Singh, Hadi Shojaei, Raymond Redline, Kimberly Resnick
BACKGROUND: Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors. CASE: A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29050508/-doing-with-%C3%A2-rather-than-doing-for-%C3%A2-older-adults-rationale-and-content-of-the-stay-active-at-home-programme
#9
Silke F Metzelthin, Gertrud Ar Zijlstra, Erik van Rossum, Janneke M de Man-van Ginkel, Barbara Resnick, Gill Lewin, Matthew Parsons, Gertrudis Ijm Kempen
BACKGROUND: Owing to increasing age, accidents or periods of illness, home care services are provided to community-dwelling older adults. Traditionally, these services focus on doing things for older adults rather than with them; though from a rehabilitative perspective, it is important to assist older adults to attain and maintain their highest level of functioning. Consequently, a re-orientation of home care services is required away from treating disease and creating dependency towards focusing on capabilities and opportunities and maximising independence...
November 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29028908/negative-affect-is-associated-with-higher-risk-of-incident-cognitive-impairment-in-nondepressed-postmenopausal-women
#10
Laura E Korthauer, Joseph Goveas, Mark A Espeland, Sally A Shumaker, Katelyn R Garcia, Hilary Tindle, Elena Salmoirago-Blotcher, Kaycee M Sink, Leslie Vaughan, Stephen R Rapp, Susan M Resnick, Ira Driscoll
BACKGROUND: Positive affect (PA) and negative affect (NA) reflect subjective emotional experiences. Although related to depression and anxiety, these dimensions are distinct constructs representing affective states and patterns. Prior studies suggest that elevated depressive symptoms are associated with risk of mild cognitive impairment (MCI) and probable dementia, but whether affective states are associated with cognitive impairment is still unknown. The present study examined relationships between baseline affective states and cognitive impairment (MCI, probable dementia) in non-depressed women...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29024571/diffuse-idiopathic-skeletal-hyperostosis-dish-increased-prevalence-in-pacific-islanders
#11
Mathew Bateman, Kamal Hapuarachchi, Clinton Pinto, Anthony James Doyle
INTRODUCTION: Diffuse idiopathic skeletal hyperostosis (DISH) is a musculoskeletal disorder in which ligaments and entheses slowly become ossified, leading to decreased mobility and pain. The prevalence is variably reported as between 3% and 25% of the population over 50. In Australasia, the prevalence and severity of DISH has long been thought by radiologists to be high in certain populations, particularly among Pacific Islanders. The purpose of this study is to investigate the prevalence and severity of DISH in a Pacific Islander community...
October 11, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28985863/early-declaration-of-death-by-neurologic-criteria-results-in-greater-organ-donor-potential
#12
Shelby Resnick, Mark J Seamon, Daniel Holena, Jose Pascual, Patrick M Reilly, Niels D Martin
BACKGROUND: Aggressive management of patients prior to and after determination of death by neurologic criteria (DNC) is necessary to optimize organ recovery, transplantation, and increase the number of organs transplanted per donor (OTPD). The effects of time management are understudied but potentially pivotal component. The objective of this study was to analyze specific time points (time to DNC, time to procurement) and the time intervals between them to better characterize the optimal timeline of organ donation...
October 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28983067/increased-loh-due-to-defective-sister-chromatid-cohesion-is-due-primarily-to-chromosomal-aneuploidy-and-not-recombination
#13
Dror Sagi, Evgeniya Marcos-Hadad, Vinay K Bari, Michael A Resnick, Shay Covo
Loss of heterozygosity (LOH) is an important factor in cancer, pathogenic fungi, and adaptation to changing environments. The sister chromatid cohesion process (SCC) suppresses aneuploidy and therefore whole chromosome LOH. SCC is also important to channel recombinational repair to sister chromatids, thereby preventing LOH mediated by allelic recombination. There is, however, insufficient information about the relative roles that the SCC pathway plays in the different modes of LOH. Here, we found that the cohesin mutation mcd1-1, and other mutations in SCC, differentially affect the various types of LOH...
October 5, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28982521/longer-operative-time-is-associated-with-increased-post-operative-complications-in-patients-undergoing-minimally-invasive-surgery-for-endometrial-cancer
#14
Sareena Singh, Karen Swarer, Kimberly Resnick
OBJECTIVE: To examine the impact of operative time on the development of post-operative medical and surgical complications in patients undergoing minimally-invasive surgery for endometrial cancer. METHODS: Patients who underwent laparoscopic surgery for endometrial cancer from 2005 to 2014 were identified from the ACS-NSQIP database. Operative times were initially divided into hour-long intervals and complication rates were determined. Outcomes included development of any complication, medical complication, or surgical complication...
October 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28975188/personality-change-in-the-preclinical-phase-of-alzheimer-disease
#15
Antonio Terracciano, Yang An, Angelina R Sutin, Madhav Thambisetty, Susan M Resnick
Importance: Changes in behavior and personality are 1 criterion for the diagnosis of dementia. It is unclear, however, whether such changes begin before the clinical onset of the disease. Objective: To determine whether increases in neuroticism, declines in conscientiousness, and changes in other personality traits occur before the onset of mild cognitive impairment or dementia. Design, Setting, and Participants: A cohort of 2046 community-dwelling older adults who volunteered to participate in the Baltimore Longitudinal Study of Aging were included...
September 20, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28974649/genome-wide-functional-analysis-reveals-central-signaling-regulators-of-lymphatic-endothelial-cell-migration-and-remodeling
#16
Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, Scott N Mueller, Kaylene J Simpson, Marc G Achen, Steven A Stacker
Lymphatic vessels constitute a specialized vasculature that is involved in development, cancer, obesity, and immune regulation. The migration of lymphatic endothelial cells (LECs) is critical for vessel growth (lymphangiogenesis) and vessel remodeling, processes that modify the lymphatic network in response to developmental or pathological demands. Using the publicly accessible results of our genome-wide siRNA screen, we characterized the migratome of primary human LECs and identified individual genes and signaling pathways that regulate LEC migration...
October 3, 2017: Science Signaling
https://www.readbyqxmd.com/read/28970647/parents-and-experts-awareness-of-learning-opportunities-in-children-s-museum-exhibits
#17
Lulu Song, Roberta Michnick Golinkoff, Amara Stuehling, Ilyse Resnick, Neha Mahajan, Kathy Hirsh-Pasek, Nora Moynihan
Informal learning outside of school are crucial for a child's development. Children's museums, in particular, are environments conducive to this sort of learning, especially when parents guide children's exploration. However, research suggests a gap between parents' and experts' perceptions of the value of informal learning. In Study 1, we asked groups of parents and experts (i.e., individuals in the community connected with the field of education or those with training in child growth and development) to rate the presence of learning opportunities available in two museum exhibits, finding that parents consistently provided lower ratings...
March 2017: Journal of Applied Developmental Psychology
https://www.readbyqxmd.com/read/28967908/using-a-novel-computational-drug-repositioning-approach-drugpredict-to-rapidly-identify-potent-drug-candidates-for-cancer-treatment
#18
A B Nagaraj, Q Q Wang, P Joseph, C Zheng, Y Chen, O Kovalenko, S Singh, A Armstrong, K Resnick, K Zanotti, S Waggoner, R Xu, A DiFeo
Computation-based drug-repurposing/repositioning approaches can greatly speed up the traditional drug discovery process. To date, systematic and comprehensive computation-based approaches to identify and validate drug-repositioning candidates for epithelial ovarian cancer (EOC) have not been undertaken. Here, we present a novel drug discovery strategy that combines a computational drug-repositioning system (DrugPredict) with biological testing in cell lines in order to rapidly identify novel drug candidates for EOC...
October 2, 2017: Oncogene
https://www.readbyqxmd.com/read/28966033/integrated-molecular-meta-analysis-of-1-000-pediatric-high-grade-and-diffuse-intrinsic-pontine-glioma
#19
Alan Mackay, Anna Burford, Diana Carvalho, Elisa Izquierdo, Janat Fazal-Salom, Kathryn R Taylor, Lynn Bjerke, Matthew Clarke, Mara Vinci, Meera Nandhabalan, Sara Temelso, Sergey Popov, Valeria Molinari, Pichai Raman, Angela J Waanders, Harry J Han, Saumya Gupta, Lynley Marshall, Stergios Zacharoulis, Sucheta Vaidya, Henry C Mandeville, Leslie R Bridges, Andrew J Martin, Safa Al-Sarraj, Christopher Chandler, Ho-Keung Ng, Xingang Li, Kun Mu, Saoussen Trabelsi, Dorra H'mida-Ben Brahim, Alexei N Kisljakov, Dmitry M Konovalov, Andrew S Moore, Angel Montero Carcaboso, Mariona Sunol, Carmen de Torres, Ofelia Cruz, Jaume Mora, Ludmila I Shats, João N Stavale, Lucas T Bidinotto, Rui M Reis, Natacha Entz-Werle, Michael Farrell, Jane Cryan, Darach Crimmins, John Caird, Jane Pears, Michelle Monje, Marie-Anne Debily, David Castel, Jacques Grill, Cynthia Hawkins, Hamid Nikbakht, Nada Jabado, Suzanne J Baker, Stefan M Pfister, David T W Jones, Maryam Fouladi, André O von Bueren, Michael Baudis, Adam Resnick, Chris Jones
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28940320/a-randomized-clinical-trial-examining-the-effect-of-video-based-prevention-of-alcohol-and-marijuana-use-among-recent-sexual-assault-victims
#20
Kate Walsh, Amanda K Gilmore, Patricia Frazier, Linda Ledray, Ron Acierno, Kenneth J Ruggiero, Dean G Kilpatrick, Heidi S Resnick
BACKGROUND: This study examined whether a brief video intervention (Prevention of Postrape Stress; PPRS) delivered in the emergency department to recent sexual assault (SA) victims reduced alcohol and marijuana use at three points over the course of a six-month follow-up compared to treatment as usual (TAU) and an active control condition (Pleasant Imagery and Relaxation Information; PIRI). Prior assault history, minority status, and pre-SA substance use also were examined as moderators of intervention efficacy...
September 20, 2017: Alcoholism, Clinical and Experimental Research
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