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Sander de Haas, Chahinda Ghossein-Doha, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the physiological pattern of gestational plasma volume adjustments during human singleton pregnancies and compare this to the pattern of pregnancies complicated by pregnancy-induced hypertension, preeclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies...
November 11, 2016: Ultrasound in Obstetrics & Gynecology
Chahinda Ghossein-Doha, Jolijn van Neer, Brechtje Wissink, Nicolette Breetveld, Leon J de Windt, Arie Pj van Dijk, Maureen J van der Vlugt, Mirian Ch Janssen, Wieteke M Heidema, Ralph R Scholten, Marc Ea Spaanderman
OBJECTIVES: Preeclampsia (PE) is on the one hand associated with postpartum structural asymptomatic heart disease, consistent with heart failure (HF) stage-B, and on the other hand with conventional cardiovascular (CV) risk factors. With this study we aim to evaluate to which extent PE together with conventional CV risk factors are associated with asymptomatic cardiac abnormalities postpartum. METHODS: In this cross-sectional cohort study, formerly PE women (n = 107) and women with uneventful pregnancies (controls) (n = 41) were invited for CV risk-assessment 4-10 years postpartum...
November 1, 2016: Ultrasound in Obstetrics & Gynecology
Giovanni Tallini, R Michael Tuttle, Ronald A Ghossein
CONTEXT: The purpose of this review is to provide the historical context to recent developments in the classification of the follicular variant of papillary thyroid carcinoma (FVPTC), an entity that has long created significant controversy. The scope is to illustrate the evolution of the diagnostic criteria for papillary thyroid carcinoma, clarifying the role of molecular analysis, and the impact on patient management. EVIDENCE ACQUISITION: A PubMed search using the terms "follicular variant" and "papillary thyroid carcinoma" covering the years 1960-2016 was performed...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Rohit Ranganath, Manish A Shaha, Bin Xu, Jocelyn Migliacci, Ronald Ghossein, Ashok R Shaha
BACKGROUND: de Quervain's thyroiditis is an inflammatory condition of the thyroid mostly treated medically, rarely requiring surgical treatment. We intend to review the surgical experience with de Quervain's thyroiditis at a tertiary cancer center over a period of 22years. METHODS: A retrospective review of medical records from 1992 to 2014 at a tertiary cancer center was performed and all patients with a histopathological diagnosis of de Quervain's thyroiditis were included...
August 18, 2016: American Journal of Otolaryngology
N K Taunk, A Laughney, R Ghossein, N Lee, C Chung, S F Bakhoum
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
September 20, 2016: Gynecologic and Obstetric Investigation
Neil M Iyengar, Ronald A Ghossein, Luc G Morris, Xi K Zhou, Amit Kochhar, Patrick G Morris, David G Pfister, Snehal G Patel, Jay O Boyle, Clifford A Hudis, Andrew J Dannenberg
BACKGROUND: Obesity is associated with increased adipose tissue in the tongue. Chronic white adipose tissue (WAT) inflammation commonly occurs in the obese. We investigated whether WAT inflammation in the tongue impacts survival in patients with squamous cell carcinoma (SCC) of the oral tongue. METHODS: In a retrospective cohort study, patients with T1 and T2 SCC of the oral tongue who underwent curative-intent resection were included. Tongue WAT inflammation was defined by the presence of dead or dying adipocytes surrounded by macrophages forming crown-like structures...
August 10, 2016: Cancer
Xue Xiao, Cybele Ghossein, Agustín Tortajada, Yuzhou Zhang, Nicole Meyer, Michael Jones, Nicolo Ghiringhelli Borsa, Carla M Nester, Christie P Thomas, Santiago Rodríquez de Córdoba, Richard J H Smith
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease characterized histologically by the predominance of C3 deposition within in the glomerulus. Familial cases of C3G are extremely uncommon and offer unique insight into the genetic drivers of complement dysregulation. In this report, we describe a patient who presented with C3G. Because a relative carried the same diagnosis, we sought an underlying genetic commonality to explain the phenotype. As part of a comprehension genetic screen, we completed multiplex ligation-dependent probe amplification across the complement factor H related region and identified amplification alterations consistent with a genomic rearrangement...
September 2016: Molecular Immunology
Bin Xu, Amandeep Aneja, Ronald Ghossein, Nora Katabi
Polymorphous low-grade adenocarcinoma (PLGA) shows histologic diversity with fascicular and targetoid features while cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominant cribriform and solid patterns with glomeruloid appearance and optical clear nuclei. The current study is designed to identify pathologic features that may predict clinical outcome in 69 PLGA/CASG. Seven patients had recurrences or distant metastasis, including 3 local recurrences, 2 nodal metastases, and 2 distant metastases...
November 2016: American Journal of Surgical Pathology
Nicolette M Breetveld, Chahinda Ghossein-Doha, Sander M J van Kuijk, Arie P van Dijk, Maureen J van der Vlugt, Wieteke M Heidema, Jolijn van Neer, Vanessa van Empel, Hans-Peter Brunner-La Rocca, Ralph R Scholten, Marc E A Spaanderman
OBJECTIVES: After preeclampsia (PE), the prevalence of structural heart disease without symptoms i.e. heart failure stage B (HF-B), may be as high as 1 out of 4 in the first year postpartum. We hypothesize that a significant number of formerly preeclamptic women with HF-B postpartum are still in their resolving period and will not have HF-B during follow-up. METHODS: In this prospective longitudinal cohort study, we included 69 formerly PE women who underwent serial echocardiographic measurements at 1 and 4 years postpartum...
July 12, 2016: Ultrasound in Obstetrics & Gynecology
Chahinda Ghossein-Doha, Louis Peeters, Marc M E Spaanderman
AIMS: To study the relationship between volume and pressure load on the one hand and relative wall thickness (RWT) on the other hand in former preeclamptic women. METHODS: In 654 former PE women, blood pressure (BP) and PV (iodine 125 albumin indicator dilution technique) where measured. PV was indexed for body surface area (BSA). Echocardiography was performed to calculate RWT. The study population was divided in 4 subgroups consisting of women with either normal- or high-systolic BP (sysBP) (<140 versus ≥140mmHg, respectively) and normal- or low-PV index (>1373 versus ≤1373 ml/m2 respectively)...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Bin Xu, Lu Wang, Laetitia Borsu, Ronald Ghossein, Nora Katabi, Ian Ganly, Snjezana Dogan
AIMS: In the current study, we aimed to examine primary parotid squamous cell carcinoma (ParSCC) for the presence of high-risk human papillomavirus (HR-HPV) and associated molecular alterations. METHODS AND RESULTS: Eight cases of ParSCC were retrieved after a detailed clinicopathological review to exclude the possibility of metastasis and/or extension from another primary site. HR-HPV status was determined on the basis of immunohistochemistry (IHC) for p16 expression and chromogenic in-situ hybridization (CISH) for HR-HPV...
December 2016: Histopathology
Bin Xu, Ronald Ghossein
Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are aggressive thyroid tumors associated with a high mortality rate of 38-57 % and almost 100 % respectively. Several recent studies utilizing next generation sequencing techniques have shed lights on the molecular pathogenesis of these tumors, providing evidence to support a stepwise tumoral progression from well-differentiated to poorly differentiated, and finally to anaplastic thyroid carcinomas. While BRAF (V600E) and RAS mutations remain the main drivers in aggressive thyroid carcinoma, PDTC and ATC gains additional mutations, e...
September 2016: Endocrine Pathology
Snjezana Dogan, Lu Wang, Ryan N Ptashkin, Robert R Dawson, Jatin P Shah, Eric J Sherman, R Michael Tuttle, James A Fagin, David S Klimstra, Nora Katabi, Ronald A Ghossein
ETV6-NTRK3 fusion was identified in several cancers including the recently described mammary analog secretory carcinoma (MASC) of the salivary glands and a minority of papillary thyroid carcinomas. We describe three cases of primary MASC of the thyroid gland and provide a detailed clinical and pathological characterization of the tumor morphology, immunoprofile, and genetic background. Immunohistochemistry for PAX8, TTF-1, thyroglobulin, mammaglobin, GCDFP-15, S-100 protein, and p63 was used to define the tumor immunophenotype...
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Adepitan A Owosho, Bin Xu, Arvin Kadempour, SaeHee K Yom, Joseph Randazzo, Ronald A Ghossein, Joseph M Huryn, Cherry L Estilo
PURPOSE: Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients' clinical outcomes. MATERIAL AND METHODS: A retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center...
August 2016: Journal of Cranio-maxillo-facial Surgery
Bin Xu, Ronald Ghossein, Jason Lane, Oscar Lin, Nora Katabi
Many patients with human papillomavirus (HPV)-related head and neck squamous cell carcinoma present initially with cervical nodal metastasis. Fine needle aspiration (FNA) of the nodal disease might be the only diagnostic material available for p16 immunohistochemistry (IHC) and HPV testing. The current study aims to evaluate p16 IHC in FNA and establish guidelines for its interpretation. The percentage and intensity of p16 IHC staining were examined in 60 matched FNA and surgical cases. Cytomorphologic features were included in the analysis...
August 2016: Human Pathology
Eugenie Du, Bruce M Wenig, Henry K Su, Meghan E Rowe, Grace C Haser, Sylvia L Asa, Zubair Baloch, William C Faquin, Giovanni Fellegara, Thomas Giordano, Ronald Ghossein, Virginia A LiVolsi, Ricardo Lloyd, Ozgur Mete, Umut Ozbek, Juan Rosai, Saul Suster, Lester D Thompson, Andrew T Turk, Mark L Urken
BACKGROUND: Extranodal extension (ENE) in lymph node metastases has been shown to worsen the prognosis of papillary thyroid cancer (PTC). Despite the clinical significance of ENE, there are no stringent criteria for its microscopic diagnosis, and its identification is subject to inter-observer variability. The objective of this study was to determine the level of agreement among expert pathologists in the identification of ENE in PTC cases. METHODS: Eleven expert pathologists from the United States, Italy, and Canada were asked to review 61 scanned slides of representative permanent sections of PTC specimens from Mount Sinai Beth Israel Medical Center in New York...
June 2016: Thyroid: Official Journal of the American Thyroid Association
Yuri E Nikiforov, Raja R Seethala, Giovanni Tallini, Zubair W Baloch, Fulvio Basolo, Lester D R Thompson, Justine A Barletta, Bruce M Wenig, Abir Al Ghuzlan, Kennichi Kakudo, Thomas J Giordano, Venancio A Alves, Elham Khanafshar, Sylvia L Asa, Adel K El-Naggar, William E Gooding, Steven P Hodak, Ricardo V Lloyd, Guy Maytal, Ozgur Mete, Marina N Nikiforova, Vania Nosé, Mauro Papotti, David N Poller, Peter M Sadow, Arthur S Tischler, R Michael Tuttle, Kathryn B Wall, Virginia A LiVolsi, Gregory W Randolph, Ronald A Ghossein
IMPORTANCE: Although growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer. OBJECTIVE: To evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological and clinical characteristics of EFVPTC. DESIGN, SETTING, AND PARTICIPANTS: International, multidisciplinary, retrospective study of patients with thyroid nodules diagnosed as EFVPTC, including 109 patients with noninvasive EFVPTC observed for 10 to 26 years and 101 patients with invasive EFVPTC observed for 1 to 18 years...
August 1, 2016: JAMA Oncology
Ramzi Hassouneh, Rania Nasrallah, Joe Zimpelmann, Alex Gutsol, David Eckert, Jamie Ghossein, Kevin D Burns, Richard L Hébert
AIMS/HYPOTHESIS: The first clinical manifestation of diabetes is polyuria. The prostaglandin E2 (PGE2) receptor EP3 antagonises arginine vasopressin (AVP)-mediated water reabsorption and its expression is increased in the diabetic kidney. The purpose of this work was to study the contribution of EP3 to diabetic polyuria and renal injury. METHODS: Male Ep 3 (-/-) (also known as Ptger3 (-/-)) mice were treated with streptozotocin (STZ) to generate a mouse model of diabetes and renal function was evaluated after 12 weeks...
June 2016: Diabetologia
Henry K Su, Bruce M Wenig, Grace C Haser, Meghan E Rowe, Sylvia L Asa, Zubair Baloch, Eugenie Du, William C Faquin, Giovanni Fellegara, Thomas Giordano, Ronald Ghossein, Virginia A LiVolsi, Ricardo Lloyd, Ozgur Mete, Umut Ozbek, Juan Rosai, Saul Suster, Lester D Thompson, Andrew T Turk, Mark L Urken
BACKGROUND: Extrathyroidal extension (ETE) is a significant prognostic factor in papillary thyroid carcinoma (PTC). Minimal extrathyroidal extension (mETE) is characterized by involvement of the sternothyroid muscle or perithyroid soft tissue, and is generally identified by light microscope examination. Patients with mETE, identified pathologically, are automatically upstaged to pT3. However, the prognostic implications of mETE have been a source of controversy in the literature. Moreover, there is also controversy surrounding the identification of mETE on pathological specimens...
April 2016: Thyroid: Official Journal of the American Thyroid Association
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