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https://www.readbyqxmd.com/read/28278337/a-proposal-to-redefine-close-surgical-margins-in-squamous-cell-carcinoma-of-the-oral-tongue
#1
Daniella Karassawa Zanoni, Jocelyn C Migliacci, Bin Xu, Nora Katabi, Pablo H Montero, Ian Ganly, Jatin P Shah, Richard J Wong, Ronald A Ghossein, Snehal G Patel
Importance: Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear...
March 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28170124/physiologic-adaptation-of-endothelial-function-to-pregnancy-a-systematic-review-and-meta-analysis
#2
REVIEW
Veronica A Lopes van Balen, Tessa A G van Gansewinkel, Sander de Haas, Sander M J van Kuijk, Joris van Drongelen, Chahinda Ghossein-Doha, Marc E A Spaanderman
OBJECTIVES: The purpose of this systematic review and meta-analysis is to establish reference values for flow mediated dilatation (FMD) and baseline brachial artery diameter in pregnancy (BBAD) and, to provide insight in the physiological and pathological course of endothelial adaptation throughout human singleton pregnancies. METHODS: A meta-analysis was performed by a systematic review of current literature on FMD, as a derivative for endothelial function, throughout uncomplicated and complicated pregnancies...
February 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28169502/physiological-adaptation-of-maternal-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#3
REVIEW
S de Haas, C Ghossein-Doha, S M J van Kuijk, J van Drongelen, M E A Spaanderman
OBJECTIVE: To describe the physiological pattern of gestational plasma volume adjustments in normal singleton pregnancy and compare this with the pattern in pregnancies complicated by pregnancy-induced hypertension, pre-eclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases...
February 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28136139/outcome-of-large-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#4
Bin Xu, Giovanni Tallini, Theresa Scognamiglio, Benjamin R Roman, R Michael Tuttle, Ronald Ghossein
BACKGROUND: In 2016, encapsulated papillary thyroid carcinoma, follicular variant without invasion was renamed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, many endocrinologists remain uneasy about managing large (≥ 4 cm) NIFTP conservatively without radioactive iodine (RAI) therapy. The objectives of this study are to characterize the clinicopathologic characteristics and outcome of large NIFTP in order to assist therapeutic decision making...
January 30, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28109741/eight-unexpected-cases-of-vancomycin-associated-acute-kidney-injury-with-contemporary-dosing
#5
J Nicholas O'Donnell, Cybele Ghossein, Nathaniel J Rhodes, Jessica Peng, Tina Lertharakul, C Kim Pham, Marc H Scheetz
Vancomycin is one of the most commonly utilized antibiotics in US hospitals. It remains the drug of choice for the treatment of serious infections caused by methicillin-resistant Staphylococcus aureus. For many of these deep-seated infections, guidelines recommend achieving troughs of 15-20 mg/L for treatment efficacy. At our institution we observed a number of cases of presumed vancomycin-induced acute tubular necrosis clinically diagnosed by the nephrology service. We report eight cases of presumed vancomycin-induced acute tubular necrosis, three of which required hemodialysis before resolution of nephrotoxicity...
January 18, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28078751/cardiac-remodelling-during-normotensive-and-hypertensive-complicated-pregnancies-a-systematic-review-and-meta-analysis
#6
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Lauren Geerts, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the normotensive pattern of cardiac remodelling during human singleton pregnancies and compared to that during hypertensive complicated pregnancies. METHODS: We performed a meta-analysis of the current literature on cardiac remodelling during normotensive and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and Embase (Ovid) databases. Included studies needed to report a reference measurement (matched non-pregnant control group, pre-pregnancy, or post-partum) and measurements during a predetermined gestational interval...
January 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28058791/re-pre-eclampsia-an-important-risk-factor-for-asymptomatic-heart-failure-c-ghossein-doha-j-van-neer-b-wissink-n-breetveld-l-j-de-windt-a-p-j-van-dijk-m-j-van-der-vlugt-m-c-h-janssen-w-m-heidema-r-r-scholten-and-m-e-a-spaanderman-ultrasound-obstet-gynecol-2017
#7
COMMENT
https://www.readbyqxmd.com/read/28058786/maternal-hemodynamics-a-2017-update
#8
EDITORIAL
C Ghossein-Doha, A Khalil, C C Lees
No abstract text is available yet for this article.
January 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28049366/primary-thyroid-carcinoma-with-low-risk-histology-and-distant-metastases-clinicopathologic-and-molecular-characteristics
#9
Bin Xu, R Michael Tuttle, Mona M Sabra, Ian Ganly, Ronald Ghossein
BACKGROUND: Distant metastases (DM) are a rare occurrence in well-differentiated thyroid carcinoma. The aim of this study was to analyze the clinical, pathologic, and molecular features of primary thyroid carcinoma with low-risk histology that develop DM. METHODS: A detailed clinicopathologic review and targeted next-generation sequencing were performed on a cohort of well-differentiated thyroid carcinoma lacking gross extrathyroidal extension, extensive vascular invasion, or significant lymph node metastases but exhibiting DM...
February 1, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27854380/physiologic-adaptation-of-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#10
REVIEW
Sander de Haas, Chahinda Ghossein-Doha, Sander Mj van Kuijk, Joris van Drongelen, Marc Ea Spaanderman
OBJECTIVE: The aim of this systematic review and meta-analyses was to comprehensively describe the physiological pattern of gestational plasma volume adjustments during human singleton pregnancies and compare this to the pattern of pregnancies complicated by pregnancy-induced hypertension, preeclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies...
November 11, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27804179/pre-eclampsia-an-important-risk-factor-for-asymptomatic-heart-failure
#11
C Ghossein-Doha, J van Neer, B Wissink, N M Breetveld, L J de Windt, A P J van Dijk, M J van der Vlugt, M C H Janssen, W M Heidema, R R Scholten, M E A Spaanderman
OBJECTIVES: Pre-eclampsia (PE) is associated with both postpartum structural asymptomatic heart disease (i.e. heart failure Stage B (HF-B)) and conventional cardiovascular (CV) risk factors. We aimed to evaluate the extent to which PE, adjusted for conventional CV risk factors, is associated independently with asymptomatic cardiac abnormalities postpartum. METHODS: In this cross-sectional cohort study, 107 formerly pre-eclamptic women and 41 women with uneventful previous pregnancy (controls) were invited for CV risk assessment 4-10 years postpartum...
January 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27732333/the-history-of-the-follicular-variant-of-papillary-thyroid-carcinoma
#12
Giovanni Tallini, R Michael Tuttle, Ronald A Ghossein
CONTEXT: The purpose of this review is to provide the historical context to recent developments in the classification of the follicular variant of papillary thyroid carcinoma (FVPTC), an entity that has long created significant controversy. The scope is to illustrate the evolution of the diagnostic criteria for papillary thyroid carcinoma, clarifying the role of molecular analysis, and the impact on patient management. EVIDENCE ACQUISITION: A PubMed search using the terms "follicular variant" and "papillary thyroid carcinoma" covering the years 1960-2016 was performed...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27686396/de-quervain-s-thyroiditis-a-review-of-experience-with-surgery
#13
Rohit Ranganath, Manish A Shaha, Bin Xu, Jocelyn Migliacci, Ronald Ghossein, Ashok R Shaha
BACKGROUND: de Quervain's thyroiditis is an inflammatory condition of the thyroid mostly treated medically, rarely requiring surgical treatment. We intend to review the surgical experience with de Quervain's thyroiditis at a tertiary cancer center over a period of 22years. METHODS: A retrospective review of medical records from 1992 to 2014 at a tertiary cancer center was performed and all patients with a histopathological diagnosis of de Quervain's thyroiditis were included...
November 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27675110/the-relationship-of-numerical-chromosomal-instability-with-clinical-characteristics-and-outcomes-in-head-and-neck-cancers-treated-with-multimodality-therapy
#14
N K Taunk, A Laughney, R Ghossein, N Lee, C Chung, S F Bakhoum
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27644043/circulating-fibronectin-and-plasminogen-activator-inhibitor-2-levels-as-possible-predictors-of-recurrent-placental-syndrome-an-exploratory-study
#15
Carmen A H Severens-Rijvers, Salwan Al-Nasiry, Chahinda Ghossein-Doha, Sara Marzano, Hugo Ten Cate, Bjorn Winkens, Marc A E Spaanderman, Louis L H Peeters
BACKGROUND/AIM: Placental syndromes (PS) are characterized by endothelial dysfunction complicating placental dysfunction. Possible markers for endothelial dysfunction and amount of trophoblast are fibronectin and plasminogen activator inhibitor-2 (PAI-2), respectively. We aimed (1) to determine whether in women with recurrent PS (rPS), this complication is preceded by deviating fibronectin- and PAI-2-levels, and (2) whether this is dependent on pre-pregnant plasma volume (PV). METHODS: In 36 former patients, we determined fibronectin- and PAI-2-levels in blood-samples collected preconceptionally and at 12-16 weeks in their next pregnancy...
September 20, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27508351/white-adipose-tissue-inflammation-and-cancer-specific-survival-in-patients-with-squamous-cell-carcinoma-of-the-oral-tongue
#16
Neil M Iyengar, Ronald A Ghossein, Luc G Morris, Xi K Zhou, Amit Kochhar, Patrick G Morris, David G Pfister, Snehal G Patel, Jay O Boyle, Clifford A Hudis, Andrew J Dannenberg
BACKGROUND: Obesity is associated with increased adipose tissue in the tongue. Chronic white adipose tissue (WAT) inflammation commonly occurs in the obese. We investigated whether WAT inflammation in the tongue impacts survival in patients with squamous cell carcinoma (SCC) of the oral tongue. METHODS: In a retrospective cohort study, patients with T1 and T2 SCC of the oral tongue who underwent curative-intent resection were included. Tongue WAT inflammation was defined by the presence of dead or dying adipocytes surrounded by macrophages forming crown-like structures...
December 15, 2016: Cancer
https://www.readbyqxmd.com/read/27490940/familial-c3-glomerulonephritis-caused-by-a-novel-cfhr5-cfhr2-fusion-gene
#17
Xue Xiao, Cybele Ghossein, Agustín Tortajada, Yuzhou Zhang, Nicole Meyer, Michael Jones, Nicolo Ghiringhelli Borsa, Carla M Nester, Christie P Thomas, Santiago Rodríquez de Córdoba, Richard J H Smith
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated renal disease characterized histologically by the predominance of C3 deposition within in the glomerulus. Familial cases of C3G are extremely uncommon and offer unique insight into the genetic drivers of complement dysregulation. In this report, we describe a patient who presented with C3G. Because a relative carried the same diagnosis, we sought an underlying genetic commonality to explain the phenotype. As part of a comprehension genetic screen, we completed multiplex ligation-dependent probe amplification across the complement factor H related region and identified amplification alterations consistent with a genomic rearrangement...
September 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27454943/predictors-of-outcome-in-the-phenotypic-spectrum-of-polymorphous-low-grade-adenocarcinoma-plga-and-cribriform-adenocarcinoma-of-salivary-gland-casg-a-retrospective-study-of-69-patients
#18
Bin Xu, Amandeep Aneja, Ronald Ghossein, Nora Katabi
Polymorphous low-grade adenocarcinoma (PLGA) shows histologic diversity with fascicular and targetoid features while cribriform adenocarcinoma of salivary gland (CASG) demonstrates predominant cribriform and solid patterns with glomeruloid appearance and optical clear nuclei. The current study is designed to identify pathologic features that may predict clinical outcome in 69 PLGA/CASG. Seven patients had recurrences or distant metastasis, including 3 local recurrences, 2 nodal metastases, and 2 distant metastases...
November 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27404208/prevalence-of-asymptomatic-heart-failure-in-formerly-pre-eclamptic-women-a-cohort-study
#19
N M Breetveld, C Ghossein-Doha, S M J van Kuijk, A P van Dijk, M J van der Vlugt, W M Heidema, J van Neer, V van Empel, H-P Brunner-La Rocca, R R Scholten, M E A Spaanderman
OBJECTIVES: After pre-eclampsia (PE), the prevalence of structural heart disease without symptoms, i.e. heart failure Stage B (HF-B), may be as high as one in four women in the first year postpartum. We hypothesize that a significant number of formerly pre-eclamptic women with HF-B postpartum are still in their resolving period and will not have HF-B during follow-up. METHODS: In this prospective longitudinal cohort study, we included 69 formerly pre-eclamptic women who underwent serial echocardiographic measurements at 1 and 4 years postpartum...
January 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27396867/a1-volume-load-and-pressure-load-both-relate-to-relative-wall-thickness-in-former-pe
#20
Chahinda Ghossein-Doha, Louis Peeters, Marc M E Spaanderman
AIMS: To study the relationship between volume and pressure load on the one hand and relative wall thickness (RWT) on the other hand in former preeclamptic women. METHODS: In 654 former PE women, blood pressure (BP) and PV (iodine 125 albumin indicator dilution technique) where measured. PV was indexed for body surface area (BSA). Echocardiography was performed to calculate RWT. The study population was divided in 4 subgroups consisting of women with either normal- or high-systolic BP (sysBP) (<140 versus ≥140mmHg, respectively) and normal- or low-PV index (>1373 versus ≤1373 ml/m2 respectively)...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
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