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https://www.readbyqxmd.com/read/28109009/using-flow-characteristics-in-three-dimensional-power-doppler-ultrasound-imaging-to-predict-complete-responses-in-patients-undergoing-neoadjuvant-chemotherapy
#1
Wei-Chung Shia, Yu-Len Huang, Hwa-Koon Wu, Dar-Ren Chen
OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28063551/d%C3%A3-claration-de-principe-commune-sogc-car-sur-l-utilisation-non-m%C3%A3-dicale-de-l-%C3%A3-chographie-f%C3%A5-tal
#2
Shia Salem, Kenneth Lim, Michiel C Van den Hof
No abstract text is available yet for this article.
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28035037/evaluation-of-a-care-transition-program-with-pharmacist-provided-home-based-medication-review-for-elderly-singaporeans-at-high-risk-of-readmissions
#3
McVin Hua Heng Cheen, Chong Ping Goon, Wan Chee Ong, Paik Shia Lim, Choon Nam Wan, Mei Yan Leong, Giat Yeng Khee
OBJECTIVE: This study aimed to determine whether pharmacist-provided home-based medication review (HBMR) can reduce readmissions in the elderly. DESIGN: Retrospective cohort study. SETTING: Patient's home. PARTICIPANTS: Records of patients referred to a care transition program from March 2011 through March 2015 were reviewed. Patients aged 60 years and older taking more than 5 medications and had at least 2 unplanned admissions within 3 months preceding the first home visit were included...
December 29, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28034727/diagnosing-colorectal-medullary-carcinoma-interobserver-variability-and-clinicopathological-implications
#4
Lik Hang Lee, Rhonda K Yantiss, Eran Sadot, Bing Ren, Marcela Santos Calvacanti, Jaclyn F Hechtman, Sinisa Ivelja, Be Huynh, Yue Xue, Tatiana Shitilbans, Hamza Guend, Zsofia K Stadler, Martin R Weiser, Efsevia Vakiani, Mithat Gonen, David S Klimstra, Jinru Shia
Colorectal medullary carcinoma, recognized by the World-Health-Organization as a distinct histologic subtype, is commonly regarded as a specific entity with an improved prognosis and unique molecular pathogenesis. A fundamental but as-yet unaddressed question, however, is whether it can be diagnosed reproducibly. In this study, by analyzing 80 colorectal adenocarcinomas whose dominant growth pattern was solid (thus encompassing medullary carcinoma and its mimics), we provided a detailed description of the morphological spectrum from "classic medullary histology" to non-medullary poorly-differentiated histologies and demonstrated significant overlapping between categories...
December 26, 2016: Human Pathology
https://www.readbyqxmd.com/read/28025786/egfr-gene-amplification-and-kras-mutation-predict-response-to-combination-targeted-therapy-in-metastatic-colorectal-cancer
#5
Sajid A Khan, Zhaoshi Zeng, Jinru Shia, Philip B Paty
Genetic variability in KRAS and EGFR predicts response to cetuximab in irinotecan refractory colorectal cancer. Whether these markers or others remain predictive in combination biologic therapies including bevacizumab is unknown. We identified predictive biomarkers from patients with irinotecan refractory metastatic colorectal cancer treated with cetuximab plus bevacizumab. Patients who received cetuximab plus bevacizumab for irinotecan refractory colorectal cancer in either of two Phase II trials conducted were identified...
December 26, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27994762/bromomethylthioindole-inspired-carbazole-hybrids-as-promising-class-of-anti-mrsa-agents
#6
Chia-Yi Cheng, Chun-Ping Chang, Tsai-Ling Yang Lauderdale, Guann-Yi Yu, Jinq-Chyi Lee, Yi-Wun Jhang, Chien-Huang Wu, Yi-Yu Ke, Amit A Sadani, Ching-Fang Yeh, I-Wen Huang, Yi-Ping Kuo, De-Jiun Tsai, Teng-Kuang Yeh, Chen-Tso Tseng, Jen-Shin Song, Yu-Wei Liu, Lun K Tsou, Kak-Shan Shia
Series of N-substituted carbazole analogues bearing an indole ring were synthesized as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents from a molecular hybridization approach. The representative compound 19 showed an MIC = 1 μg/mL against a panel of MRSA clinical isolates as it possessed comparable in vitro activities to that of vancomycin. Moreover, compound 19 also exhibited MIC = 1 μg/mL activities against a recent identified Z172 MRSA strain (vancomycin-intermediate and daptomycin-nonsusceptible phenotype) and the vancomycin-resistant Enterococcus faecalis (VRE) strain...
December 8, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27982025/morphological-characterization-of-colorectal-cancers-in-the-cancer-genome-atlas-reveals-distinct-morphology-molecular-associations-clinical-and-biological-implications
#7
Jinru Shia, Nikolaus Schultz, Deborah Kuk, Efsevia Vakiani, Sumit Middha, Neil H Segal, Jaclyn F Hechtman, Michael F Berger, Zsofia K Stadler, Martin R Weiser, Jedd D Wolchok, C Richard Boland, Mithat Gönen, David S Klimstra
The Cancer Genome Atlas data on colorectal carcinoma have provided a comprehensive view of the tumor's genomic alterations and their tumorigenic roles. Tumor morphology, however, has not been fully integrated into the analysis. The aim of this study was to explore relevant associations between tumor morphology and the newly characterized genomic alterations in colorectal carcinoma. Two hundred and seven colorectal carcinomas that had undergone whole-exome sequencing as part of The Cancer Genome Atlas project and had adequate virtual images in the cBioPortal for Cancer Genomics constituted our study population...
December 16, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27977490/mandibular-contouring-during-orthognathic-surgery-using-the-modified-hunsuck-technique
#8
Ying-An Chen, Li Shia Ng, Ellen Wen-Ching Ko, Yu-Ray Chen
Square face or prominent mandibular angle is a major concern in Asian women. In class III patients, mandibular setback may lead to a wider lower face that is not preferred in Asian culture. In order to achieve better aesthetic outcomes, simultaneous mandibular contouring to reduce the width of the lower face is required for some patients. This article details the authors' procedures modified from Hunsuck techniques of sagittal split osteotomy. This modified Hunsuck technique provides an alternative option to obtain a desirable mandibular outline...
December 13, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27938478/a-novel-cxcr4-antagonist-cx549-induces-neuroprotection-in-stroke-brain
#9
Kou-Jen Wu, Seong-Jin Yu, Kak-Shan Shia, Chien-Huang Wu, Jen-Shin Song, Hsuan-Hao Kuan, Kai-Chia Yeh, Chiung-Tong Chen, Eunkyune Bae, Yun Wang
C-X-C chemokine receptor type 4 (CXCR4) is a receptor for a pleiotropic chemokine CXCL12. Previous studies have shown that the acute administration of the CXCR4 antagonist AMD3100 reduced neuroinflammation in stroke brain and mobilized bone marrow hematopoietic stem cells (HSCs). The purpose of this study was to characterize the neuroprotective and neurotrophic effect of a novel CXCR4 antagonist CX549. We demonstrated that CX549 had a higher affinity for CXCR4 and was more potent than AMD3100 to inhibit CXCL12 -mediated chemotaxis in culture...
27, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27935861/microrna-203-predicts-human-survival-after-resection-of-colorectal-liver-metastasis
#10
T Peter Kingham, Hoang C B Nguyen, Jian Zheng, Ioannis T Konstantinidis, Eran Sadot, Jinru Shia, Deborah Kuk, Steven Zhang, Leonard Saltz, Michael I D'Angelica, William R Jarnagin, Hani Goodarzi, Sohail F Tavazoie
BACKGROUND: Resection of colorectal liver metastasis (CRLM) can be curative. Predicting which patients may benefit from resection, however, remains challenging. Some microRNAs (miRNAs) become deregulated in cancers and contribute to cancer progression. We hypothesized that miRNA expression can serve as a prognostic marker of survival after CRLM resection. RESULTS: MiR-203 was significantly overexpressed in tumors of short-term survivors compared to long-term survivors...
December 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27920984/staphylococcus-lugdunensis-endocarditis-with-destruction-of-the-ventricular-septum-and-multiple-native-valves
#11
Celestine Ishiekwene, Monica Ghitan, Margaret Kuhn-Basti, Edward Chapnick, Yu Shia Lin
Staphylococcus lugdunensis (S. lugdunensis) is a coagulase negative staphylococcus (CoNS) that can cause destructive infective endocarditis. S. lugdunensis, unlike other CoNS, should be considered to be a pathogen. We report the first case of S. lugdunensis endocarditis causing ventricular septal defect and destruction of the aortic and mitral valves. A 53-year-old male with morbid obesity and COPD presented with intermittent fever and progressive shortness of breath for 2 weeks. Chest examination showed bilateral basal crepitations, and a grade 2 systolic murmur along the right sternal border...
2017: IDCases
https://www.readbyqxmd.com/read/27903953/sociocultural-characteristic-lifestyle-and-metabolic-risk-factors-among-a-sample-of-kuwaiti-male-university-students
#12
Maha Al-Sejari
In the past six decades, the Kuwaiti population has been exposed to rapid transformation in the quality of diet intake, daily activities, and career types. This major socioeconomic shift was accompanied by the introduction of both communicable and noncommunicable chronic diseases afflicting people of all ages. This article aims to detect a relationship between sociocultural characteristics-such as physical activity, dietary habits, and smoking-and the prevalence of metabolic syndrome (MetS). A descriptive, cross-sectional survey was conducted among 262 male university students in Kuwait; participants were selected by using a convenient nonrandom opportunistic sample...
November 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27891214/one-step-immortalization-of-primary-human-airway-epithelial-cells-capable-of-oncogenic-transformation
#13
Jordan L Smith, Liam C Lee, Abigail Read, Qiuning Li, Bing Yu, Chih-Shia Lee, Ji Luo
BACKGROUND: The ability to transform normal human cells into cancer cells with the introduction of defined genetic alterations is a valuable method for understanding the mechanisms of oncogenesis. Easy establishment of immortalized but non-transformed human cells from various tissues would facilitate these genetic analyses. RESULTS: We report here a simple, one-step immortalization method that involves retroviral vector mediated co-expression of the human telomerase protein and a shRNA targeting the CDKN2A gene locus...
2016: Cell & Bioscience
https://www.readbyqxmd.com/read/27875625/clinical-and-genetic-determinants-of-ovarian-metastases-from-colorectal-cancer
#14
Karuna Ganesh, Ronak H Shah, Efsevia Vakiani, Garrett M Nash, Hugh P Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H Segal, Diane L Reidy, Anna Varghese, Andrew S Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F Berger, Leonard Saltz, Zsofia K Stadler
BACKGROUND: Ovarian metastases from colorectal cancer (OM-CRC) often are unresponsive to chemotherapy and are associated with poor survival. To the authors' knowledge, the clinicopathologic and genomic predictors of OM-CRC are poorly characterized and optimal clinical management remains unclear. METHODS: Women with a histopathological diagnosis of OM-CRC who were treated at Memorial Sloan Kettering Cancer Center from 1999 to 2015 were identified. Next-generation somatic mutation profiling (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) was performed on 38 OM-CRC cases, including 21 matched tumor pairs/trios...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27829279/combined-intrahepatic-cholangiocarcinoma-and-hepatocellular-carcinoma
#15
Louise C Connell, James J Harding, Jinru Shia, Ghassan K Abou-Alfa
Hepatocellular carcinoma (HCC), the fifth most common cancer globally and third leading cause of cancer-related mortality is a heterogeneous disease with a highly variable clinical course. The inherent biological diversity of hepatic carcinomas may hinder therapeutic decision making and prognostication for patients. One distinct, albeit rare, subtype of primary hepatic carcinoma is combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma (cHCC-ICC), which carries an overall worse prognosis than either HCC or intrahepatic cholangiocarcinoma (ICC) alone...
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27829276/biliary-carcinomas-pathology-and-the-role-of-dna-mismatch-repair-deficiency
#16
Vitor Werneck Krauss Silva, Gokce Askan, Tanisha D Daniel, Maeve Lowery, David S Klimstra, Ghassan K Abou-Alfa, Jinru Shia
The pathology of biliary carcinomas is diverse with different gross and histological features in tumors arising in the different segments of the biliary system. Various epidemiological risk factors, varied genetic makeup, and tissue microenvironment are contributory factors. As biliary tumors have been shown to be a part of the Lynch syndrome tumor spectrum, it is plausible to speculate that DNA mismatch repair (MMR) deficiency plays a role in biliary tumors. Literature data suggest that DNA MMR deficiency indeed occurs in these tumors, albeit infrequently with the reported frequencies (weighted for sample size) of high level microsatellite instability (MSI) being 5% each for gallbladder carcinoma and carcinoma of extra-hepatic bile ducts, and 10% each for intrahepatic cholangiocarcinoma and ampullary carcinoma...
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27822848/islam-and-environmental-consciousness-a-new-scale-development
#17
Hossein Emari, Hossein Vazifehdoust, Hashem Nikoomaram
This research proposed a new construct, Islamic environmental consciousness (IEC), and developed a measurement scale to support this construct. Churchill's (J Mark Res 16(1):64-73, 1979) paradigm, adapted by Negra and Mzoughi (Internet Res 22(4):426-442, 2012), was utilized. A total of 32 items were generated based on the verses of the Qur'an from nine interviews with teachers in an Islamic seminary. This set of items was reduced to 19 after dropping redundant or non-representative items. In a pilot study, factor analysis of the 19-item scale yielded a two-factor structure scale of seven items with a reliability ranging from 0...
November 7, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27781382/hepatocellular-adenoma-among-adult-survivors-of-childhood-and-young-adult-cancer
#18
Emily S Tonorezos, Dana Barnea, Ghassan K Abou-Alfa, Jacqueline Bromberg, Michael D'Angelica, Charles A Sklar, Jinru Shia, Kevin C Oeffinger
Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal...
October 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27750001/cobalt-ii-catalyzed-aerobic-oxidation-of-terminal-capped-alkynyl-%C3%AE-cyano-alkanone-systems-an-oxygen-mediated-radical-chain-reaction
#19
Jing-Kai Huang, Ying-Chieh Wong, Tzu-Ting Kao, Chen-Tso Tseng, Kak-Shan Shia
A new N-hydroxyphthalimide (NHPI)/Co(II)-catalyzed protocol, mechanistically involving a sequence of α-hydrogen abstraction, 5-exo-dig cyclization, oxygen capture, hydrogen transfer, and 1,4-dehydration, has been developed to facilitate aerobic oxidation of aryl-, silyl-, and alkyl-capped alkynyl α-cyano alkanone systems to the corresponding highly functionalized products in an effective manner, thus turning this novel chain reaction, originally occurring spontaneously in low yields, into a practical methodology...
November 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27681620/structure-guided-enzymology-of-the-lipid-a-acyltransferase-lpxm-reveals-a-dual-activity-mechanism
#20
Dustin Dovala, Christopher M Rath, Qijun Hu, William S Sawyer, Steven Shia, Robert A Elling, Mark S Knapp, Louis E Metzger
Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the outer leaflet of the outer membrane and are produced through a multistep biosynthetic pathway conserved in most Gram-negative bacteria. The final steps in this pathway involve the secondary acylation of lipid A precursors...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
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