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Jing-Kai Huang, Ying-Chieh Wong, Tzu-Ting Kao, Chen-Tso Tseng, Kak-Shan Shia
A new NHPI/Co(II)-catalyzed protocol, mechanistically involving a sequence of alpha-hydrogen abstraction, 5-exo-dig cyclization, oxygen capture, hydrogen transfer and 1,4-dehydration, has been developed to facilitate aerobic oxidation of aryl-, silyl- and alkyl-capped alkynyl alpha-cyano alkanone systems, respectively, to the corresponding highly functionalized products in an effective manner, thus turning this novel chain reaction, originally occurring spontaneously in low yields, into a practical methodology...
October 17, 2016: Journal of Organic Chemistry
Dustin Dovala, Christopher M Rath, Qijun Hu, William S Sawyer, Steven Shia, Robert A Elling, Mark S Knapp, Louis E Metzger
Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the outer leaflet of the outer membrane and are produced through a multistep biosynthetic pathway conserved in most Gram-negative bacteria. The final steps in this pathway involve the secondary acylation of lipid A precursors...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Yuan Huang, Jin Liu, Huangdi Yi, Ben-Chang Shia, Shuangge Ma
In profiling studies, the analysis of a single dataset often leads to unsatisfactory results because of the small sample size. Multi-dataset analysis utilizes information of multiple independent datasets and outperforms single-dataset analysis. Among the available multi-dataset analysis methods, integrative analysis methods aggregate and analyze raw data and outperform meta-analysis methods, which analyze multiple datasets separately and then pool summary statistics. In this study, we conduct integrative analysis and marker selection under the heterogeneity structure, which allows different datasets to have overlapping but not necessarily identical sets of markers...
September 25, 2016: Statistics in Medicine
Sunil V Patel, Campbell S Roxburgh, Efsevia Vakiani, Jinru Shia, J Joshua Smith, Larissa K Temple, Philip Paty, Julio Garcia-Aguilar, Garrett Nash, Jose Guillem, Abraham Wu, Marsha Reyngold, Martin R Weiser
BACKGROUND AND OBJECTIVES: Achieving a pathologic complete response (pCR) after neoadjuvant therapy has been associated with better prognosis in rectal cancer patients. The objective of this study was to investigate the relationship between distance to the anal verge (DTAV) and pCR. METHODS: Review of a prospectively maintained database of patients with locally advanced rectal cancer who received neoadjuvant treatment was completed. Uni- and multivariate analysis assessed the association between DTAV and pCR after neoadjuvant therapy...
September 19, 2016: Journal of Surgical Oncology
Olca Basturk, Sun M Chung, Ralph H Hruban, N Volkan Adsay, Gokce Askan, Christine Iacobuzio-Donahue, Serdar Balci, Sui Y Zee, Bahar Memis, Jinru Shia, David S Klimstra
Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is classified as a variant of intraductal papillary mucinous neoplasm (IPMN) in the WHO guidelines. However, the neoplastic cells of IOPNs are unique, with distinctive architecture/oncocytic cytoplasm. Although molecular/immunohistochemical features of other IPMN variants have been extensively studied, those of IOPNs have not been well characterized. Expression profile of antibodies associated with genetic alterations previously described for ductal adenocarcinomas (DAs) and IPMNs (SMAD4/β-catenin/p53/mesothelin/claudin-4) as well as antibodies to mucins and differentiation markers [MUC1/MUC2/MUC5AC/MUC6/CDX2/hepatocyte paraffin-1 (HepPar-1)] was investigated in 24 IOPNs and 22 IPMNs to assess the similarities/differences between these tumors...
September 3, 2016: Virchows Archiv: An International Journal of Pathology
Sajid A Khan, Melinda Morris, Kamran Idrees, Mark I Gimbel, Shoshana Rosenberg, Zhaoshi Zeng, Fangyong Li, Geliang Gan, Jinru Shia, Michael P LaQuaglia, Philip B Paty
INTRODUCTION: Colorectal cancer (CRC) diagnosed before age 30 years is a fatal disease whose biology remains poorly understood. To understand its pathogenesis, we compared molecular and clinical data in surgically treated early-age onset and adult onset patients. MATERIALS AND METHODS: Clinical data and tumor tissue were collected retrospectively for 94 patients with early-age onset CRC (age ≤30 years) and compared to 275 adult CRC patients (age ≥50 years). Tumor morphology, microsatellite instability (MSI) and stability (MSS), KRAS and BRAF mutations, and mismatch repair (MMR) expression (MSH2, MLH1, MSH6, PMS2) were assessed...
November 2016: Journal of Pediatric Surgery
Lik Hang Lee, Marcela S Cavalcanti, Neil H Segal, Jaclyn F Hechtman, Martin R Weiser, J Joshua Smith, Julio Garcia-Aguilar, Eran Sadot, Peter Ntiamoah, Arnold J Markowitz, Moshe Shike, Zsofia K Stadler, Efsevia Vakiani, David S Klimstra, Jinru Shia
Immune checkpoint blockade targeting the programmed death-1 (PD-1) pathway has shown efficacy in several types of cancers including mismatch-repair-deficient colorectal carcinoma. In some tumor types, programmed death-ligand 1 (PD-L1) expression detected by immunohistochemistry has shown utility as a predictive marker for response to anti-PD-1 therapies. This utility, however, remains to be determined in colorectal carcinoma. In addition, although tumor-infiltrating lymphocytes have been associated with better prognosis in colorectal carcinoma, the prognostic value of PD-1 expression in these lymphocytes and its interaction with PD-L1 expression still await investigation...
July 22, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Gabriel S Tajeu, Shia T Kent, Ian M Kronish, Lei Huang, Marie Krousel-Wood, Adam P Bress, Daichi Shimbo, Paul Muntner
Low antihypertensive medication adherence is common. During recent years, the impact of low medication adherence on increased morbidity and healthcare costs has become more recognized, leading to interventions aimed at improving adherence. We analyzed a 5% sample of Medicare beneficiaries initiating antihypertensive medication between 2007 and 2012 to assess whether reductions occurred in discontinuation and low adherence. Discontinuation was defined as having no days of antihypertensive medication supply for the final 90 days of the 365 days after initiation...
September 2016: Hypertension
Gokce Askan, Vikram Deshpande, David S Klimstra, Volkan Adsay, Carlie Sigel, Jinru Shia, Olca Basturk
OBJECTIVES: Pancreatic acinar cell carcinoma (ACC) is a rare tumor that frequently metastasizes to the liver and may present a diagnostic challenge due to its morphologic similarity to hepatocellular carcinoma. We investigated α-fetoprotein (AFP), hepatocyte paraffin antigen 1 (HepPar 1), glypican 3, arginase 1, and albumin messenger RNA (mRNA) in situ hybridization (ISH) in pancreatic neoplasms with ACC differentiation to assess their diagnostic value. METHODS: AFP, HepPar 1, glypican 3, and arginase 1 immunohistochemical staining was performed on 28 ACCs using a tissue microarray...
August 2016: American Journal of Clinical Pathology
Umesh C Karandikar, Sue E Crawford, Nadim J Ajami, Kosuke Murakami, Baijun Kou, Khalil Ettayebi, Genovefa A Papanicolaou, Ubonvan Jongwutiwes, Miguel-Angel Perales, Jinru Shia, David Mercer, Milton J Finegold, Jan Vinjé, Robert L Atmar, Mary K Estes
Human noroviruses (HuNoVs) can often cause chronic infections in solid organ and haematopoietic stem cell transplant (HSCT) patients. Based on histopathological changes observed during HuNoV infections, the intestine is the presumed site of virus replication in patients; however, the cell types infected by HuNoVs remain unknown. The objective of this study was to characterize histopathological changes during HuNoV infection and to determine the cell types that may be permissive for HuNoV replication in transplant patients...
September 2016: Journal of General Virology
Adam L Washburn, Winnie W Shia, Kimberly A Lenkeit, So-Hyun Lee, Ryan C Bailey
The analysis of disease-specific biomarker panels holds promise for the early detection of a range of diseases, including cancer. Blood-based biomarkers, in particular, are attractive targets for minimally-invasive disease diagnosis. Specifically, a panel of organ-specific biomarkers could find utility as a general disease surveillance tool enabling earlier detection or prognostic monitoring. Using arrays of chip-integrated silicon photonic sensors, we describe the simultaneous detection of eight cancer biomarkers in serum in a relatively rapid (1 hour) and fully automated antibody-based sandwich assay...
September 21, 2016: Analyst
Lisandro D Colantonio, Shia T Kent, Lei Huang, Ligong Chen, Keri L Monda, Maria-Corina Serban, Angelika Manthripragada, Meredith L Kilgore, Robert S Rosenson, Paul Muntner
PURPOSE: To compare characteristics of patients with possible statin intolerance identified using different claims-based algorithms versus patients with high adherence to statins. METHODS: We analyzed 134,863 Medicare beneficiaries initiating statins between 2007 and 2011. Statin intolerance and discontinuation, and high adherence to statins, defined by proportion of days covered ≥80 %, were assessed during the 365 days following statin initiation. Definition 1 of statin intolerance included statin down-titration or discontinuation with ezetimibe initiation, having a claim for a rhabdomyolysis or antihyperlipidemic event followed by statin down-titration or discontinuation, or switching between ≥3 types of statins...
July 7, 2016: Cardiovascular Drugs and Therapy
Stephen G Rostand, Leslie A McClure, Shia T Kent, Suzanne E Judd, Orlando M Gutiérrez
BACKGROUND: Vitamin D deficiency/insufficiency is associated with hypertension. Blood pressure (BP) and circulating vitamin D concentrations vary with the seasons and distance from the equator suggesting BP varies inversely with the sunshine available (insolation) for cutaneous vitamin D photosynthesis. METHODS: To determine if the association between insolation and BP is partly explained by vitamin D, we evaluated 1104 participants in the Reasons for Racial and Geographic Differences in Stroke study whose BP and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were measured...
September 2016: Journal of Hypertension
Breanna M Javier, Rona Yaeger, Lu Wang, Francisco Sanchez-Vega, Ahmet Zehir, Sumit Middha, Justyna Sadowska, Efsevia Vakiani, Jinru Shia, David Klimstra, Marc Ladanyi, Christine A Iacobuzio-Donahue, Jaclyn F Hechtman
PURPOSE: The extent to which the developmental transcription factor SOX9 functions as an oncogene or tumor suppressor in colorectal carcinoma (CRC) is debatable. We aimed to clarify the effect of SOX9 mutations on SOX9 protein expression and their association with known molecular subtypes and clinical characteristics in advanced CRC. EXPERIMENTAL DESIGN: Next generation sequencing data (MSK-IMPACT) from CRC patients was used to interrogate SOX9, KRAS, NRAS, BRAF, TP53, APC, and PIK3CA...
May 29, 2016: Oncotarget
Carlie Sigel, Marcela S Cavalcanti, Tanisha Daniel, Efsevia Vakiani, Jinru Shia, Keith Sigel
BACKGROUND: Emerging evidence suggests differences in colorectal cancer in HIV-infected patients (HIV(+)) compared with HIV(-) patients. Microsatellite instability (MSI), occurring in a subset of colorectal cancer, is present at a higher rate in certain cancers in HIV(+) patients. Colorectal cancer with MSI share some characteristics with those reported for HIV(+) colorectal cancer. On this premise, we studied clinical and pathologic features of HIV(+) colorectal cancer and evaluated for MSI using matched HIV(-) colorectal cancer controls...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
Mualla Öner, Berna İlhan
The aim of this study was to prepare poly(3-hydroxybutyrate-co-3-hydroxyvalerate), PHBV, biocomposites with incorporating various percentages of hydroxyapatite (HAP) using extrusion processing. The biocomposites were produced by melt extrusion of PHBV with untreated HAP and surface-treated HAP crystals. The structure of biopolymer/HAP biocomposites was investigated by XRD, FTIR, DSC and SEM. Silane coupling agent was used for HAP surface treatment in PHBV/HAP composites. Silane-treated HAP nanoparticles yielded nanocomposites characterized by good mechanical performance and fine nanofiller dispersion, as shown by SEM investigations...
August 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Bekir S Kocazeybek, Pelin Yuksel, Dilek Keskin, Suhail Sheikh, Zafer Habip, Serap Sahin Yavuzer, Reyhan Caliskan, Yagız Meric Altun, Mert Kuskucu, Mahir Cengiz, Harika Oyku Dinc, Asiye Karakullukcu, Sevgi Ergin, Suat Saribas, Nail Yilmaz, Hrisi Bahar Tokman
BACKGROUND: Although Legionella pneumophila serogroup 1 is the common disease causing serogroup, rare serogroups can also may cause legionellosis. A 54-year-old male patient (index case) reported that he had been on a religious trip (for visiting, tomb of Ali, which is important for Shias) to Iraq with a large group (50 shia pilgrims from Kars city of Turkey) two weeks prior to admission. Due to civil war, the hotel where the patient stayed in Iraq lacked proper hygiene. A large number of people in the travel group were experiencing the same symptoms...
May 2016: Travel Medicine and Infectious Disease
Chung-Ping Yu, Chi-Sheng Shia, Hui-Ju Lin, Yow-Wen Hsieh, Shiuan-Pey Lin, Yu-Chi Hou
Aloe-emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro. The aim of this study was to investigate the pharmacokinetics and metabolism of aloe-emodin. Aloe-emodin was intravenously and orally administered to rats. The concentrations of aloe-emodin and rhein, a metabolite of aloe-emodin, were determined by HPLC method prior to and after hydrolysis with β-glucuronidase and sulfatase/β-glucuronidase. The results showed that the systemic exposures of aloe-emodin and its metabolites were ranked as aloe-emodin glucuronides (G) > rhein sulfates (S) > aloe-emodin > rhein and rhein G when aloe-emodin was given intravenously...
October 2016: Biomedical Chromatography: BMC
Edmund Seto, Jenna Hua, Lemuel Wu, Victor Shia, Sue Eom, May Wang, Yan Li
INTRODUCTION: Smartphone applications (apps) facilitate the collection of data on multiple aspects of behavior that are useful for characterizing baseline patterns and for monitoring progress in interventions aimed at promoting healthier lifestyles. Individual-based models can be used to examine whether behavior, such as diet, corresponds to certain typological patterns. The objectives of this paper are to demonstrate individual-based modeling methods relevant to a person's eating behavior, and the value of such approach compared to typical regression models...
2016: PloS One
Zsofia K Stadler, Francesca Battaglin, Sumit Middha, Jaclyn F Hechtman, Christina Tran, Andrea Cercek, Rona Yaeger, Neil H Segal, Anna M Varghese, Diane L Reidy-Lagunes, Nancy E Kemeny, Erin E Salo-Mullen, Asad Ashraf, Martin R Weiser, Julio Garcia-Aguilar, Mark E Robson, Kenneth Offit, Maria E Arcila, Michael F Berger, Jinru Shia, David B Solit, Leonard B Saltz
PURPOSE: Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actionable mutations could also reliably identify tumors with DNA mismatch repair protein deficiency (MMR-D) on the basis of increased mutational load. METHODS: We identified all CRCs that underwent genomic mutation profiling with a custom NGS assay (MSK-IMPACT) between March 2014 and July 2015...
June 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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