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https://www.readbyqxmd.com/read/28734798/barriers-to-conducting-ambulatory-and-home-blood-pressure-monitoring-during-hypertension-screening-in-the-united-states
#1
Ian M Kronish, Shia Kent, Nathalie Moise, Daichi Shimbo, Monika M Safford, Robert E Kynerd, Ronan O'Beirne, Alexandra Sullivan, Paul Muntner
In 2015, the US Preventive Services Task Force updated their hypertension recommendations to advise that adults with elevated office blood pressure (BP) undergo out-of-office BP measurement to exclude white coat hypertension before diagnosis. Our goal was to determine the most important barriers to primary care providers' ordering ambulatory and home BP monitoring in the United States. We enrolled 63 primary care providers into nominal group panels in which participants iteratively listed and ranked barriers to ambulatory and home BP monitoring...
July 6, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28729225/gynura-divaricata-attenuates-tumor-growth-and-tumor-relapse-after-cisplatin-therapy-in-hcc-xenograft-model-through-suppression-of-cancer-stem-cell-growth-and-wnt-%C3%AE-catenin-signalling
#2
Chia-Hung Yen, Chi-Chung Lai, Tsu-Hsiang Shia, Marcelo Chen, Hsin-Che Yu, Yu-Peng Liu, Fang-Rong Chang
ETHNOPHARMACOLOGICAL RELEVANCE: Gynura divaricata subsp. formosana is a widely used traditional herbal medicine for treating liver disorders such as hepatitis and liver cancer in Taiwan. AIM OF THE STUDY: This study was aimed to evaluate the anti-cancer and cancer stabilization effect of water extract of the aerial part of G. divaricata (GD extract) both in vitro and in vivo. MATERIALS AND METHODS: Cytotoxicity and anti-proliferative effects of GD extract alone and in combination with cisplatin were determined by alamarBlue and clonogenic assay...
July 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28649796/lymph-node-yield-in-right-colectomies-for-cancer-a-comparison-of-open-laparoscopic-and-robotic-approaches
#3
Maria Widmar, Metin Keskin, Paul Strombom, Pedro Beltran, Oliver S Chow, J Joshua Smith, Garrett M Nash, Jinru Shia, David Russell, Julio Garcia-Aguilar
AIM: Studies have demonstrated a relationship between lymph node (LN) yield and survival after colectomy for cancer. The impact of surgical technique on lymph node yield has not been well explored. METHOD: This is a retrospective study of right colectomies (RC) for cancer at a single institution from 2012-2014. Exclusion criteria were previous colectomy, emergent and palliative operations. All data were collected by chart review. Primary outcomes were LN yield and the lymph node to length of surgical specimen (LN-LSS) ratio...
June 26, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28635408/assisted-reproductive-technologies-and-the-iranian-community-attitude-towards-infertility
#4
Aliyar Ahmadi, Sara Bamdad
Since the late 1990s, assisted reproductive technologies (ARTs) have been legitimized in Iran through an official religious endorsement. Iran, under the dominant authority of the Shia sect, is now the most enthusiastic adopter of ARTs in the Muslim world, permitting all forms of treatments, including third party donation. This study examined the public perception of assisted conception and its influence on the adoption of these methods in Iran. The study was questionnaire-based and conducted in 2012 in Shiraz, the most populated city in the south of Iran...
February 7, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28624171/race-and-sex-differences-in-ambulatory-blood-pressure-measures-among-hiv-adults
#5
Shia T Kent, Joseph E Schwartz, Daichi Shimbo, Edgar T Overton, Greer A Burkholder, Suzanne Oparil, Michael J Mugavero, Paul Muntner
Ambulatory blood pressure monitoring (ABPM) can identify phenotypes that cannot be measured in the clinic. Determining race and sex disparities in ABPM measures among HIV+ individuals may improve strategies to diagnose and treat hypertension in this high-risk population. We compared ABPM measures between 24 African-American and 25 white HIV+ adults (36 men and 13 women). Awake systolic blood pressure (SBP) and diastolic blood pressure (DBP) were similar in African-Americans and whites. After multivariable adjustment, sleep SBP and DBP were 9...
May 25, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28581724/targeting-tumor-associated-phosphatidylserine-with-new-zinc-dipicolylamine-based-drug-conjugates
#6
Yu-Wei Liu, Kak-Shan Shia, Chien-Huang Wu, Kuan-Liang Liu, Yu-Cheng Yeh, Chen-Fu Lo, Chiung-Tong Chen, Yun-Yu Chen, Teng-Kuang Yeh, Wei-Han Chen, Jiing-Jyh Jan, Yu-Chen Huang, Chen-Lung Huang, Ming-Yu Fang, Brian D Gray, Koon Y Pak, Tsu-An Hsu, Kuan-Hsun Huang, Lun K Tsou
A series of zinc(II) dipicolylamine (ZnDPA)-based drug conjugates have been synthesized to probe the potential of phosphatidylserine (PS) as a new antigen for small molecule drug conjugate (SMDC) development. Using in vitro cytotoxicity and plasma stability studies, PS-binding assay, in vivo pharmacokinetic studies, and maximum tolerated dose profiles, we provided a roadmap and the key parameters required for the development of the ZnDPA based drug conjugate. In particular, conjugate 24 induced tumor regression in the COLO 205 xenograft model and exhibited a more potent antitumor effect with a 70% reduction of cytotoxic payload compared to that of the marketed irinotecan when dosed at the same regimen...
June 19, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28560599/computed-tomography-image-texture-a-noninvasive-prognostic-marker-of-hepatic-recurrence-after-hepatectomy-for-metastatic-colorectal-cancer
#7
Amber L Simpson, Alexandre Doussot, John M Creasy, Lauryn B Adams, Peter J Allen, Ronald P DeMatteo, Mithat Gönen, Nancy E Kemeny, T Peter Kingham, Jinru Shia, William R Jarnagin, Richard K G Do, Michael I D'Angelica
BACKGROUND: Recurrence after resection of colorectal liver metastases (CRLMs) occurs in up to 75% of patients. Preoperative prediction of hepatic recurrence may inform therapeutic strategies at the time of initial resection. Texture analysis (TA) is an established technique that quantifies pixel intensity variations (heterogeneity) on cross-sectional imaging. We hypothesized that tumoral and parenchymal changes that are predictive of overall survival (OS) and recurrence in the future liver remnant (FLR) can be detected using TA on preoperative computed tomography (CT) images...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28555354/contiguous-gene-deletion-of-chromosome-2p16-3-p21-as-a-cause-of-lynch-syndrome
#8
Erin E Salo-Mullen, Patricio B Lynn, Lu Wang, Michael Walsh, Anuradha Gopalan, Jinru Shia, Christina Tran, Fung Ying Man, Sean McBride, Mark Schattner, Liying Zhang, Martin R Weiser, Zsofia K Stadler
Lynch syndrome is an autosomal dominant condition caused by pathogenic mutations in the DNA mismatch repair (MMR) genes. Although commonly associated with clinical features such as intellectual disability and congenital anomalies, contiguous gene deletions may also result in cancer predisposition syndromes. We report on a 52-year-old male with Lynch syndrome caused by deletion of chromosome 2p16.3-p21. The patient had intellectual disability and presented with a prostatic adenocarcinoma with an incidentally identified synchronous sigmoid adenocarcinoma that exhibited deficient MMR with an absence of MSH2 and MSH6 protein expression...
May 29, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28538573/pursuing-mirror-image-reconstruction-in-unilateral-microtia-customizing-auricular-framework-by-application-of-three-dimensional-imaging-and-three-dimensional-printing
#9
Hsin-Yu Chen, Li-Shia Ng, Chun-Shin Chang, Ting-Chen Lu, Ning-Hung Chen, Zung-Chung Chen
BACKGROUND: Advances in three-dimensional imaging and three-dimensional printing technology have expanded the frontier of presurgical design for microtia reconstruction from two-dimensional curved lines to three-dimensional perspectives. This study presents an algorithm for combining three-dimensional surface imaging, computer-assisted design, and three-dimensional printing to create patient-specific auricular frameworks in unilateral microtia reconstruction. METHODS: Between January of 2015 and January of 2016, six patients with unilateral microtia were enrolled...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28476018/local-recurrences-at-the-anastomotic-area-are-clonally-related-to-the-primary-tumor-in-sporadic-colorectal-carcinoma
#10
Efsevia Vakiani, Ronak H Shah, Michael F Berger, Alvin P Makohon-Moore, Johannes G Reiter, Irina Ostrovnaya, Marc A Attiyeh, Andrea Cercek, Jinru Shia, Christine A Iacobuzio-Donahue, David B Solit, Martin R Weiser
PURPOSE: Anastomotic recurrences (AR) occur in 2-10% of colorectal carcinoma cases after resection of primary tumor (PT). Currently, there are no molecular data investigating their genetic profile and multiple theories exist about their pathogenesis. The aim of our study was to compare the genomic profile of AR to that of the patients' corresponding matched PT and, when available, to a distant metastasis (DM). EXPERIMENTAL DESIGN: Thirty-six tumors from 14 patients were genotyped using a capture-based, next-generation assay to define the mutational status of 341 cancer-associated genes...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453819/evaluation-of-a-care-transition-program-with-pharmacist-provided-home-based-medication-review-for-elderly-singaporeans-at-high-risk-of-readmissions
#11
McVin Hua Heng Cheen, Chong Ping Goon, Wan Chee Ong, Paik Shia Lim, Choon Nam Wan, Mei Yan Leong, Giat Yeng Khee
Objective: This study aimed to determine whether pharmacist-provided home-based medication review (HBMR) can reduce readmissions in the elderly. Design: Retrospective cohort study. Setting: Patient's home. Participants: Records of patients referred to a care transition program from March 2011 through March 2015 were reviewed. Patients aged 60 years and older taking more than 5 medications and had at least 2 unplanned admissions within 3 months preceding the first home visit were included...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28302290/statin-intolerance-and-risk-of-coronary-heart-events-and-all-cause-mortality-following-myocardial-infarction
#12
Maria-Corina Serban, Lisandro D Colantonio, Angelika D Manthripragada, Keri L Monda, Vera A Bittner, Maciej Banach, Ligong Chen, Lei Huang, Ricardo Dent, Shia T Kent, Paul Muntner, Robert S Rosenson
BACKGROUND: Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES: This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare beneficiaries with statin intolerance and in those with high adherence to statin therapy. METHODS: We studied 105,329 Medicare beneficiaries who began a moderate- or high-intensity statin dosage after hospitalization for MI between 2007 and 2013...
March 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28268763/generating-physically-realistic-kinematic-and-dynamic-models-from-small-data-sets-an-application-for-sit-to-stand-actions
#13
Robert Peter Matthew, Victor Shia, Gentiane Venture, Ruzena Bajcsy
Kinematic and dynamic models are used to create simplified, yet accurate representations of reality. In application to biological systems, there is often a choice on what level of complexity is appropriate for the model. This paper introduces a structured method for obtaining an accurate model that can represent the sit-to-stand motion and reproduce the associated contact forces in the standing phase. These models are generated from small datasets, just five measured sit-to-stand actions, and result in simple, physically realisable dynamic models...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28242162/molecular-screening-for-lynch-syndrome-in-young-patients-with-colorectal-adenomas
#14
Robin B Mendelsohn, Keri Herzog, Jinru Shia, Nadiyah Rahaman, Zsofia K Stadler, Moshe Shike
BACKGROUND: The frequency of mismatch repair (MMR) deficiency (dMMR) in patients < 50 years with adenomas without a known germline mutation is unknown. Our aim was to define the frequency of dMMRs in adenomas from patients aged < 50 years. PATIENTS AND METHODS: We identified all patients aged 18 to 49 years who had undergone colonoscopy at Memorial Sloan Kettering Cancer Center from 2008 to 2013 and were identified as having tubular, villous, or tubulovillous adenomas on pathology...
February 2, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28226951/generating-physically-realistic-kinematic-and-dynamic-models-from-small-data-sets-an-application-for-sit-to-stand-actions
#15
Robert Peter Matthew, Victor Shia, Gentiane Venture, Ruzena Bajcsy, Robert Peter Matthew, Victor Shia, Gentiane Venture, Ruzena Bajcsy, Robert Peter Matthew, Gentiane Venture, Victor Shia, Ruzena Bajcsy
Kinematic and dynamic models are used to create simplified, yet accurate representations of reality. In application to biological systems, there is often a choice on what level of complexity is appropriate for the model. This paper introduces a structured method for obtaining an accurate model that can represent the sit-to-stand motion and reproduce the associated contact forces in the standing phase. These models are generated from small datasets, just five measured sit-to-stand actions, and result in simple, physically realisable dynamic models...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28214614/predicting-medical-professionals-intention-to-allow-family-presence-during-resuscitation-a-cross-sectional-survey
#16
Meng-Kuan Lai, Bayu Aji Aritejo, Jing-Shia Tang, Chien-Liang Chen, Chia-Chang Chuang
BACKGROUND: Family presence during resuscitation is an emerging trend, yet it remains controversial, even in countries with relatively high acceptance of family presence during resuscitation among medical professionals. Family presence during resuscitation is not common in many countries, and medical professionals in these regions are unfamiliar with family presence during resuscitation. Therefore, this study predicted the medical professionals' intention to allow family presence during resuscitation by applying the theory of planned behaviour...
February 11, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28213791/tumor-associated-macrophage-infiltration-in-colorectal-cancer-liver-metastases-is-associated-with-better-outcome
#17
Michael J Cavnar, Simon Turcotte, Steven C Katz, Deborah Kuk, Mithat Gönen, Jinru Shia, Peter J Allen, Vinod P Balachandran, Michael I D'Angelica, T Peter Kingham, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Tumor-associated macrophages (TAMs) support growth in most human cancers, with the notable exception of colorectal adenocarcinoma, in which TAM infiltration of primary tumors is correlated with a better outcome. The importance of TAMs in colorectal liver metastases (CLM) is unknown. METHODS: Using a tissue microarray of CLM resected at their institution from 1998 to 2000, the authors quantified immune marker expression by immunohistochemistry (IHC) using Metamorph Image Analysis software...
July 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28184012/chromosome-20q-amplification-defines-a-subtype-of-microsatellite-stable-left-sided-colon-cancers-with-wild-type-ras-raf-and-better-overall-survival
#18
Ryan N Ptashkin, Carlos Pagan, Rona Yaeger, Sumit Middha, Jinru Shia, Kevin P O'Rourke, Michael F Berger, Lu Wang, Robert Cimera, Jiajing Wang, David S Klimstra, Leonard Saltz, Marc Ladanyi, Ahmet Zehir, Jaclyn F Hechtman
Here, comprehensive analysis was performed on the molecular and clinical features of colorectal carcinoma harboring chromosome 20q amplification. Tumor and normal DNA from patients with advanced colorectal carcinoma underwent next-generation sequencing via MSK-IMPACT, and a subset of case samples was subjected to high-resolution microarray (Oncoscan). Relationships between genomic copy number and transcript expression were assessed with The Cancer Genome Atlas (TCGA) colorectal carcinoma data. Of the colorectal carcinoma patients sequenced (n = 401) with MSK-IMPACT, 148 (37%) had 20q gain, and 30 (7%) had 20q amplification...
June 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28180066/case-report-on-pulmonary-disease-due-to-coinfection-of-mycobacterium-tuberculosis-and-mycobacterium-abscessus-difficulty-in-diagnosis
#19
Celestine Ishiekwene, Mala Subran, Monica Ghitan, Margaret Kuhn-Basti, Edward Chapnick, Yu Shia Lin
Mycobacterium abscessus, which is ubiquitous environmental organism, is more likely to cause pulmonary infection in the presence underlying lung disease and immunosuppression. We report a case of pulmonary disease due to coinfection of Mycobacterium tuberculosis (MTB) and Mycobacterium abscessus (M. abscessus) in an immunocompetent patient without underlying lung disease. Healthcare professionals should be aware of co-infection with MTB and M. abscessus, and treatment should be based on clinical suspicion and/or epidemiological circumstances...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28176646/epigenetic-regulation-of-emt-in-non-small-cell-lung-cancer
#20
Karen O'Leary, Alice Shia, Peter Schmid
Lung cancer remains the most diagnosed cancer in the world, with a high mortality rate and fewer therapeutic options. The most common lung cancer is non-small cell, which can consist of adenocarcinoma, squamous cell carcinoma and large cell lung carcinoma. As per all solid tumours, the changes that occur for the initiation and metastasis of lung cancer can be described using the EMT (epithelial mesenchymal transition). Cells progressing through EMT lose their epithelial cell characteristics, expressing more mesenchymal markers and are phenotypically different...
February 3, 2017: Current Cancer Drug Targets
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