Arielle Elkrief, Nicholas R Waters, Natalie Smith, Anqi Dai, John Slingerland, Nathan Aleynick, Binita Febles, Pooja Gogia, Nicholas D Socci, Melissa Lumish, Paul A Giardina, Jamie E Chaft, Juliana Eng, Robert J Motzer, Robin B Mendelsohn, Kate A Markey, Mingqiang Zhuang, Yanyun Li, Zhifan Yang, Travis J Hollmann, Charles M Rudin, Marcel R M van den Brink, Jinru Shia, Susan DeWolf, Adam J Schoenfeld, Matthew D Hellmann, N Esther Babady, David M Faleck, Jonathan U Peled
Colitis induced by treatment with immune checkpoint inhibitors (ICI), termed irColitis, is a substantial cause of morbidity complicating cancer treatment. We hypothesized that abnormal fecal microbiome features would be present at the time of irColitis onset, and that restoring the microbiome with fecal transplant from a healthy donor would mitigate disease severity. Herein, we present fecal microbiota profiles from 18 patients with irColitis from a single center, 5 of whom were treated with healthy donor fecal microbial transplantation (FMT)...
December 18, 2023: Cancer Immunology Research