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https://www.readbyqxmd.com/read/28717630/ptx3-a-new-mediator-of-bone-metabolism-and-osteoporosis
#1
Umberto Tarantino, Maurizio Feola, Monica Celi, Manuel Scimeca
No abstract text is available yet for this article.
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28708509/gdf8-activates-p38-mapk-signaling-during-porcine-oocyte-maturation-in%C3%A2-vitro
#2
Junchul David Yoon, Seon-Ung Hwang, Eunhye Kim, Minghui Jin, Soochong Kim, Sang-Hwan Hyun
Growth Differentiation Factor 8 (GDF8) is a member of the transforming growth factor-β (TGF-β) family and has been identified as a strong physiological regulator. This factor is expressed as a paracrine factor in mural granulosa cells. To investigate the effects of GDF8 on the in vitro maturation (IVM) of porcine oocytes, we assessed the quality of matured oocytes as well as the specific gene transcription and protein activation levels in oocytes and cumulus cells (CCs) after IVM and subsequent embryonic development after in vitro fertilization (IVF) and parthenogenetic activation (PA)...
June 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/28705996/different-gene-response-to-mechanical-loading-during-early-and-late-phases-of-rat-achilles-tendon-healing
#3
Malin Hammerman, Parmis Blomgran, Arie Dansac, Pernilla Eliasson, Per Aspenberg
Mechanical loading stimulates tendon healing both when applied in the inflammatory phase and in the early remodeling phase of the process, although not necessarily via the same mechanisms. We investigated the gene response to mechanical loading in these two phases of tendon healing. The right Achilles tendon in rats was transected and the hind limbs were unloaded by tail suspension. The rats were exposed to 5 minutes of treadmill running 3 or 14 days after tendon transection. Thereafter, they were re-suspended for 15 minutes or 3 hours until euthanasia...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28700471/plasma-cytokines-can-help-to-identify-the-development-of-severe-acute-pancreatitis-on-admission
#4
Li-Hui Deng, Cheng Hu, Wen-Hao Cai, Wei-Wei Chen, Xiao-Xin Zhang, Na Shi, Wei Huang, Yun Ma, Tao Jin, Zi-Qi Lin, Kun Jiang, Jia Guo, Xiao-Nan Yang, Qing Xia
Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicytokine array, were submitted to quantitative determination using either microparticle-based multiplex immunoassays analyzed on a Luminex 100 platform or enzyme-linked immunosorbent assay kits...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28673381/biomarkers-of-necrotising-soft-tissue-infections-aspects-of-the-innate-immune-response
#5
Marco Bo Hansen
Necrotising soft tissue infection (NSTI) is a life-threatening and rapidly progressing bacterial infection involving one or more layers of the soft tissue compartments causing necrosis. The amputation and mortality rates remain high despite increased focus on the patients. Timely treatment, including surgical intervention, reduces the risk of severe disability and death. However, the lack of pathognomonic signs impedes early diagnosis and treatment. Moreover, the rarity of the disease makes it difficult to conduct large prospective studies, thus prospective research is almost non-existent in this group of patients...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28667205/prospective-observational-study-in-two-dutch-hospitals-to-assess-the-performance-of-inflammatory-plasma-markers-to-determine-disease-severity-of-viral-respiratory-tract-infections-in-children
#6
Inge M L Ahout, Kim H Brand, Aldert Zomer, Wilhelma H van den Hurk, Geurt Schilders, Marianne L Brouwer, Chris Neeleman, Ronald de Groot, Gerben Ferwerda
INTRODUCTION: Respiratory viruses causing lower respiratory tract infections (LRTIs) are a major cause of hospital admissions in children. Since the course of these infections is unpredictable with potential fast deterioration into respiratory failure, infants are easily admitted to the hospital for observation. The aim of this study was to examine whether systemic inflammatory markers can be used to predict severity of disease in children with respiratory viral infections. METHODS: Blood and nasopharyngeal washings from children <3 years of age with viral LRTI attending a hospital were collected within 24 hours (acute) and after 4-6 weeks (recovery)...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28664745/association-between-pentraxin-3-and-growth-differentiation-factor-15-in-adolescent-male-swimmers
#7
N Karakuyu, M Belviranli, N Okudan
BACKGROUND: The purpose of this study was to evaluate plasma pentraxin 3 (PTX3) and growth differentiation factor-15 (GDF-15) concentrations in adolescent male swimmers and compare any possible interactions with canonical biochemical parameters. METHODS: Twenty-six adolescent male swimmers and 29 gender- and age-matched sedentary controls participated in this study. Fasting blood samples were taken from the participants. Biochemical values and plasma PTX3 and GDF-15 levels were measured...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28643381/clinical-association-between-chronic-periodontitis-and-the-leukocyte-extravasation-inhibitors-developmental-endothelial-locus-1-and-pentraxin-3
#8
Matthias Folwaczny, Evangelia Karnesi, Tamara Berger, Ekaterini Paschos
This clinical study aimed to determine whether periodontal disease is associated with expression of developmental endothelial locus-1 (Del-1) and pentraxin-3 (PTX-3), endogenous inhibitors of leukocyte extravasation in humans. Expression of DEL1, PTX3, interleukin-17A (IL17A), and lymphocyte function-associated antigen-1 (LFA1) was determined, using RT-PCR and melting curve analysis, in biopsies of gingival tissues from 95 patients: 42 with moderate periodontitis; 40 with severe periodontitis; and 13 healthy controls...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28619036/monocyte-differentiation-and-macrophage-priming-are-regulated-differentially-by-pentraxins-and-their-ligands
#9
Darrell Pilling, Elkin Galvis-Carvajal, Tejas R Karhadkar, Nehemiah Cox, Richard H Gomer
BACKGROUND: Circulating bone marrow-derived monocytes can leave the blood, enter a tissue, and differentiate into M1 inflammatory, M2a remodeling/fibrotic, or M2c/Mreg resolving/immune-regulatory macrophages. Macrophages can also convert from one of the above types to another. Pentraxins are secreted proteins that bind to, and promote efficient clearance of, microbial pathogens and cellular debris during infection, inflammation, and tissue damage. The pentraxins C-reactive protein (CRP), serum amyloid P (SAP), and pentraxin-3 (PTX3) can also bind a variety of endogenous ligands...
June 15, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28601054/association-of-serum-levels-of-pentraxin-3-m-ficolin-and-surfactant-protein-a-with-the-severity-of-ischemic-stroke
#10
Ebrahim Kouchaki, Atousa Babamohammadi, Hassan Nikoueinejad, Mojtaba Sehat
Stroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke. There are no defined biological serum markers to determine the severity of stroke in acute phases. The purpose of current study was to determine the association of three complement activators, namely Pentraxin-3 (PTX3),M-ficolin, and Surfactant protein A (SPA) with the severity of ischemic stroke. This cross-sectional study was done on 82 patients diagnosed with ischemic stroke at 24-96 hours of initiation of the clinical symptoms during 2014-2015...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28585705/ganglioside-gm3-induces-cumulus-cell-apoptosis-through-inhibition-of-epidermal-growth-factor-receptor-mediated-pi3k-akt-signaling-pathways-during-in-vitro-maturation-of-pig-oocytes
#11
Hyo-Jin Park, Sung-Kyu Chae, Jin-Woo Kim, Seul-Gi Yang, Jae-Min Jung, Min-Ji Kim, Gabbine Wee, Dong-Seok Lee, Sun-Uk Kim, Deog-Bon Koo
Gangliosides are components of the mammalian plasma membrane that help regulate receptor signaling. Ganglioside GM3, for example, plays an important role in initiating apoptosis in cancer cells; however, physiological roles for GM3 in normal processes, such as during pig oocyte maturation, are not clear. The aim of this study was to investigate the functional link between GM3 and cellular apoptosis in porcine cumulus-oocyte-complexes (COCs) during in vitro maturation. Our results indicated that denuded oocytes possess less ST3GAL5, a GM3-synthesizing enzyme, than cumulus cells or COCs after 44 hr of in vitro maturation...
June 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28574494/aqueous-humor-pentraxin-3-levels-in-patients-with-diabetes-mellitus
#12
M Mutlu, N Yuksel, T Takmaz, A S Dincel, A Bilgihan, H Altınkaynak
PurposeTo evaluate aqueous humor (AH) pentraxin-3 (PTX3) levels in diabetic patients with and without diabetic retinopathy (DR).MethodsIn this prospective study, patients undergoing cataract surgery were enrolled. The study group was composed of 26 type-2 diabetic patients without DR (group 1), 32 diabetic patients with DR (group 2) and 29 age-matched subjects without any systemic disease (group 3). Fifteen proliferative DR (PDR) and 17 non-proliferative DR (NPDR) patients were enrolled in Group 2. HbA1c levels and duration of diabetes were noted...
June 2, 2017: Eye
https://www.readbyqxmd.com/read/28555437/autoimmunity-in-2016
#13
REVIEW
Carlo Selmi
The number of peer-reviewed articles published during the 2016 solar year and retrieved using the "autoimmunity" key word remained stable while gaining a minimal edge among the immunology articles. Nonetheless, the quality of the publications has been rising significantly and, importantly, acquisitions have become available through scientific journals dedicated to immunology or autoimmunity. Major discoveries have been made in the fields of systemic lupus erythematosus, rheumatoid arthritis, autoimmunity of the central nervous system, vasculitis, and seronegative spondyloarthrithritides...
August 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28536575/inflammatory-long-pentraxin-3-is-associated-with-leukocyte-telomere-length-in-night-shift-workers
#14
Sofia Pavanello, Mariarita Stendardo, Giuseppe Mastrangelo, Melissa Bonci, Barbara Bottazzi, Manuela Campisi, Marco Nardini, Roberto Leone, Alberto Mantovani, Piera Boschetto
Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses and stressful conditions associate with age-related disorders. Additionally, circadian rhythm disruption, a critical health issue in night-shift workers, correlates with premature aging. We investigated the hypothesis of a link between altered inflammatory response, detected by plasmatic long pentraxin 3 (PTX3), and biological aging, measured by leukocyte telomere length (LTL), attrition, and possibly induced by night-shift work...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28489600/oleate-induced-ptx3-promotes-head-and-neck-squamous-cell-carcinoma-metastasis-through-the-up-regulation-of-vimentin
#15
Shih-Hung Chan, Jhih-Peng Tsai, Chih-Jie Shen, Yu-Han Liao, Ben-Kuen Chen
The association between metabolic diseases and the risk of developing cancer is emerging. However, the impact of long pentraxin-3 (PTX3) on dyslipidemia-associated tumor metastasis remains unknown. In this study, we found that oleate induced PTX3 expression and secretion through the activation of Akt/NF-κB pathway in head and neck squamous cell carcinomas (HNSCCs). The activation of NF-κB was essential for the oleate-induced stabilization of PTX3 mRNA. In addition, both the depletion of PTX3 and the inhibition of NF-κB significantly inhibited oleate-induced tumor cell migration and invasion...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487045/pentraxin-3-levels-in-bronchoalveolar-lavage-fluid-of-lung-transplant-recipients-with-invasive-aspergillosis
#16
Dima Kabbani, Archana Bhaskaran, Lianne G Singer, Alyajahan Bhimji, Coleman Rotstein, Shaf Keshavjee, W Conrad Liles, Shahid Husain
BACKGROUND: Invasive aspergillosis is the most common invasive fungal infection in lung transplant recipients. The use of galactomannan testing in bronchoalveolar lavage (BAL) fluid has improved diagnosis of invasive aspergillosis; however, false-positive results can lead to overdiagnosis and unnecessary treatment. The use of proinflammatory markers such as pentraxin 3 (PTX3) may help differentiate between Aspergillus colonization and disease. METHODS: BAL PTX3 concentrations were measured by enzyme-linked immunosorbent assay in 151 lung transplant recipients and 9 healthy control subjects...
April 19, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28475193/metabolomic-profiling-and-biochemical-evaluation-of-the-follicular-fluid-of-endometriosis-patients
#17
Santonastaso Marianna, Pucciarelli Alessia, Costantini Susan, Caprio Francesca, Sorice Angela, Capone Francesca, Natella Antonella, Iardino Patrizia, Colacurci Nicola, Chiosi Emilio
Diseases are complex systems that can be studied through the integration of data derived from different disciplines to obtain a global and reliable picture of the biological phenomenon under investigation. Based on the recent observations that the metabolomics profiling of follicular fluids reflects the ovarian microenvironment of women and that endometriosis represents an example of complex diseases, clearly diagnosed by laparoscopy, we thought that the follicular fluids of endometriosis patients can represent a study model to evaluate the possibility of integrating data obtained by different approaches...
June 1, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28471269/anti-pentraxin-antibodies-in-autoimmune-systemic-diseases-focus-on-anti-pentraxin-3-autoantibodies
#18
Jean-François Augusto, Caroline Poli, Céline Beauvillain, Jean-François Subra, Sebastien Jaillon, Gilles Renier, Alain Chevailler, Xavier Puéchal, Yves Delneste, Pascale Jeannin
Pentraxins are soluble pattern recognition molecules implicated not only in the opsonization and removal of microorganisms but also in the clearance of modified self (i.e., dying cells). Pentraxins can be classified into short pentraxins (C-reactive protein and serum amyloid-P component) and long pentraxins with pentraxin-3 (PTX3), the prototypic one of the latter. Pentraxins are involved in various physiological or pathophysiological processes such as inflammation and autoimmunity. A breakdown in immune tolerance to pentraxins has been reported in various autoimmune diseases...
May 4, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28458531/investigating-the-role-of-pentraxin-3-as-a-biomarker-for-bacterial-infection-in-subjects-with-copd
#19
Samantha J Thulborn, Madiha Dilpazir, Koirobi Haldar, Vijay Mistry, Christopher E Brightling, Michael R Barer, Mona Bafadhel
BACKGROUND: Pentraxin 3 (PTX3) is an acute phase protein, involved in antibacterial resistance. Recent studies have shown PTX3 levels to be elevated in the presence of a bacterial infection and in a murine sepsis model. OBJECTIVE: We aim to investigate if sputum PTX3 can be used as a biomarker for bacterial infection in subjects with COPD. MATERIALS AND METHODS: Sputum samples from 142 COPD patients (102 men) with a mean (range) age of 69 years (45-85) and mean (SD) post-bronchodilator percentage predicted forced expiratory volume in 1 second (FEV1) of 50% (19) were analyzed for PTX3, using a commercial assay at stable state and during an exacerbation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28457653/study-of-the-relationship-between-apoa-ii%C3%A2-265t-c-polymorphism-and-hdl-function-in-response-to-weight-loss-in-overweight-and-obese-type-2-diabetic-patients
#20
Masoumeh Moradi, Maryam Mahmoudi, Ahmad Saedisomeolia, Mohammad Ali Mansournia, Roxana Zahirihashemi, Fariba Koohdani
BACKGROUND: It has been reported that people may respond differently to the same environmental changes because of genome variations. OBJECTIVE: The main purpose of the present study is to determine gene-diet interactions between -265T>C apolipoprotein A-II polymorphisms and evaluate the effect of weight loss on parameters related to HDL function. METHODS: In the present study, 56 overweight and obese type 2 diabetic patients were chosen from 697 genotype-specified subjects...
April 9, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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