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https://www.readbyqxmd.com/read/29755506/genome-wide-association-study-for-susceptibility-to-and-recoverability-from-mastitis-in-danish-holstein-cows
#1
B G Welderufael, Peter Løvendahl, Dirk-Jan de Koning, Lucas L G Janss, W F Fikse
Because mastitis is very frequent and unavoidable, adding recovery information into the analysis for genetic evaluation of mastitis is of great interest from economical and animal welfare point of view. Here we have performed genome-wide association studies (GWAS) to identify associated single nucleotide polymorphisms (SNPs) and investigate the genetic background not only for susceptibility to - but also for recoverability from mastitis. Somatic cell count records from 993 Danish Holstein cows genotyped for a total of 39378 autosomal SNP markers were used for the association analysis...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29755398/deconvolution-of-human-brain-cell-type-transcriptomes-unraveled-microglia-specific-potential-biomarkers
#2
R Ayana, Shailja Singh, Soumya Pati
Microglial cells form a context-dependent network of brain immunoeffector cells. Despite their indispensable roles, unresolved questions exist around biomarker discovery relevant to their cellular localization, self-renewing potential, and brain developmental dynamics. To resolve the existent gap in the annotation of candidate biomarkers, we conducted a meta-analysis of brain cells using available high-throughput data sets for deciphering microglia-specific expression profiles. We have identified 3,290 significant genes specific to microglia and further selected the top 20 dysregulated genes on the basis of p -value and log2 FC...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29754456/pentraxin-levels-in-noneosinophilic-versus-eosinophilic-asthma
#3
Pengfei Gao, Kun Tang, Meijia Wang, Qun Yang, Yongjian Xu, Jianmiao Wang, Jianping Zhao, Jungang Xie
BACKGROUND: Innate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or noneosinophilic asthma. OBJECTIVE: To investigate whether pentraxin levels differ in subjects with eosinophilic versus noneosinophilic asthma. Furthermore, to access the predictive performance of pentraxin levels for discriminating asthma inflammatory phenotypes...
May 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29748720/aerobic-fitness-alters-the-capacity-of-mononuclear-cells-to-produce-pentraxin-3-following-maximal-exercise
#4
Aaron L Slusher, Tiffany M Zúñiga, Edmund O Acevedo
PURPOSE: Pentraxin 3 (PTX3) is a vital regulator of innate immune function. Although plasma PTX3 concentrations are elevated with aerobic fitness, the cellular functions of PTX3 remain unknown in aerobically trained and untrained subjects. METHODS: Thirty individuals (aerobically trained = 15 and untrained = 15) participated in a maximal exercise protocol to examine ex vivo PTX3 production from isolated peripheral blood mononuclear cells (PBMCs) exposed to LPS or palmitate...
May 10, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29744755/radiological-histological-and-chemical-analysis-of-breast-microcalcifications-diagnostic-value-and-biological-significance
#5
Rita Bonfiglio, Manuel Scimeca, Nicola Toschi, Chiara Adriana Pistolese, Elena Giannini, Chiara Antonacci, Sara Ciuffa, Virginia Tancredi, Umberto Tarantino, Loredana Albonici, Elena Bonanno
Classification of mammary microcalcifications is based on radiological and histological characteristics that are routinely evaluated during the diagnostic path for the identification of breast cancer, or in patients at risk of developing breast cancer. The main aim of this study was to explore the relationship between the imaging parameters most commonly used for the study of mammary microcalcifications and the corresponding histological and chemical properties. To this end, we matched the radiographic characteristics of microcalcifications to breast lesion type, histology of microcalcifications and elemental composition of microcalcifications as obtained by energy dispersive x ray (EDX)-microanalysis...
May 9, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29742255/circulation-levels-of-acute-phase-proteins-pentraxin-3-and-serum-amyloid-a-in-atherosclerosis-have-correlations-with-periodontal-inflamed-surface-area
#6
Başak Temelli, Zuhal Yetkin Ay, Hasan Basri Savaş, Fatih Aksoy, Duygu Kumbul Doğuç, Ersin Uskun, Ercan Varol
Objectives One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29742137/genetic-characterization-of-indigenous-goat-breeds-in-romania-and-hungary-with-a-special-focus-on-genetic-resistance-to-mastitis-and-gastrointestinal-parasitism-based-on-40-snps
#7
Daniela Elena Ilie, Szilvia Kusza, Maria Sauer, Dinu Gavojdian
Goat breeding has become an important sector in Eastern Europe, with Romania and Hungary being among the major producer countries. Given the limited number of research done up-to-date concerning genetic studies of indigenous goat breeds reared in Romania and Hungary, the current preliminary study aimed to analyze the variability of genes related to mastitis and gastrointestinal parasitism by using Kompetitive Allele Specific PCR (KASP™). We studied 52 single nucleotide polymorphisms (SNPs) belonging to 19 genes in indigenous breeds from both countries, namely Banat's White (n = 36), Carpatina (n = 35) from Romania and Hungarian Milking (n = 79) and identified 16 polymorphic SNPs among 10 genes (PTX3, IL6, CLEC4E, IL8, IL1RN, IL15RA, TNFSF13, SOCS3, TNF and TLR3) in 150 animals...
2018: PloS One
https://www.readbyqxmd.com/read/29741292/microrna-150-restores-endothelial-cell-function-and-attenuates-vascular-remodeling-by-targeting-ptx3-through-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-mice-with-acute-coronary-syndrome
#8
Xian-Yuan Luo, Xiao-Qing Zhu, Ying Li, Xue-Bin Wang, Wei Yin, Yi-Shan Ge, Wei-Min Ji
MicroRNAs have been known to function as important regulators in the vascular system, with various physiopathological effects such as vascular remodeling and hypertension modulation. We aimed to explore whether microRNA-150 (miR-150) regulates endothelial cell function and vascular remodeling in acute coronary syndrome (ACS), and the involvement of PTX3 and NF-κB signaling pathway. Ten normal mice and sixty ApoE-/- mice were chosen, and their coronary artery tissues and endothelial cells were extracted. ApoE-/- mice were injected with a series of inhibitors or mimics for miR-150, or siRNA against PTX3...
May 9, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29738271/plasma-pentraxin-3-and-glucose-kinetics-to-acute-high-intensity-interval-exercise-versus-continuous-moderate-intensity-exercise-in-healthy-men
#9
Aaron L Slusher, Michael Whitehurst, Arun Maharaj, Katelyn M Dodge, Brandon G Fico, J Thomas Mock, Chun-Jung Huang
Pentraxin 3 (PTX3) is mainly synthesized and released by neutrophils to help regulate innate immunity. While plasma PTX3 concentrations are associated with improved glucose metabolism and overall metabolic health, evidence has shown that significant elevations in plasma glucose downregulates circulating levels of PTX3. To examine whether or not this relationship would be altered in response to exercise, this study investigated the kinetics of the plasma glucose and PTX3 response following high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE)...
May 8, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29736308/spocd1-promotes-the-proliferation-and-metastasis-of-glioma-cells-by-up-regulating-ptx3
#10
Quan Liu, Xiao-Yu Wang, Yuan-Yuan Qin, Xian-Lei Yan, Hong-Mou Chen, Qi-Dan Huang, Jia-Kang Chen, Jie-Min Zheng
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasms in the central nervous system. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) has been recently identified and found to discriminate progressive from non-progressive bladder cancers. In this study, we detected high-level of SPOCD1 expression in glioma and its high expression significantly associated with advanced tumor grade and poor prognosis. In vitro assays showed that knockdown of SPOCD1 significantly inhibited cell proliferation and colony formation capacities in U373 and U87 cells...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29731826/expression-and-influence-of-pentraxin-3-hbalc-and-apoa1-apob-in-serum-of-patients-with-acute-myocardial-infarction-combined-with-diabetes-mellitus-type-2
#11
Yanxia Zhu, Xiaofang Wang, Weihua Wang, Hongguang Wang, Fenglei Zhang
The present study investigated the clinical significance of changes in levels of hypersensitive plasma pentraxin-3 (PTX3), hemoglobin A1c (HbAlc) and apolipoprotein A-I (ApoA1)/apolipoprotein B (ApoB) on patients with acute myocardial infarction (AMI) and diabetes mellitus type 2 (T2DM). After admission, 100 patients diagnosed with AMI combined with T2DM were selected as Group A. According to the level of fasting blood glucose (FBG), they were then subdivided into Group A1 (n=44) with FBG ≥13.0 mmol/l and Group A2 (n=56) with FBG <13...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29729868/treatment-of-takayasu-arteritis-with-the-il-6r-antibody-tocilizumab-vs-cyclophosphamide
#12
Xiufang Kong, Xiaojie Zhang, Peng Lv, Xiaomeng Cui, Lili Ma, Huiyong Chen, Hao Liu, Jiang Lin, Lindi Jiang
OBJECTIVE: To evaluate the treatment effects of the IL-6R antibody tocilizumab and cyclophosphamide (CTX) in patients with Takayasu arteritis (TA) and explore the mechanism by analyzing their effects on various cytokines. METHODS AND MATERIALS: This study included 9 TA patients treated with tocilizumab, 15 TA patients treated with CTX and 24 healthy controls. Treatment effects were evaluated based on: (1) Kerr score and Indian Takayasu Clinical Activity Score (ITAS2010), (2) improvement of previous lesions and occurrence of new vascular lesions on magnetic resonance angiography (MRA), (3) changes in various cytokine levels, (4) glucocorticoid sparing, and (5) adverse effects...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29725602/study-on-association-of-pentraxin-3-and-diabetic-nephropathy-in-a-rat-model
#13
Xuehai Chen, Jiao Luo, Minmin Wu, Zhuo Pan, Yue Xie, Hongwei Wang, Bicheng Chen, Hong Zhu
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation. Methods . Diabetes was induced in rats by injecting streptozotocin (STZ)...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29715313/circulating-pentraxin-3-is-positively-associated-with-chronic-hyperglycemia-but-negatively-associated-with-plasma-aldosterone-concentration
#14
Yuichi Takashi, Minae Koga, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
Pentraxin 3 (PTX3) is reported to be a vascular inflammation marker providing prognostic information of vasculopathy. Until today, however, the effect of aldosterone or oxidative stress on the regulation of PTX3 is unknown. In present study, we investigated to find regulative factors, especially aldosterone and oxidative stress, on PTX3. Serum PTX3 levels were measured in 75 patients (45 male and 30 women, aged 55.1±13.4 year-old (mean±SD)) with various endocrine disorders including 47 with diabetes, 24 with primary aldosteronism (PA)...
2018: PloS One
https://www.readbyqxmd.com/read/29682101/evaluation-of-mediators-associated-with-the-inflammatory-response-in-prostate-cancer-patients-undergoing-radiotherapy
#15
Nice Bedini, Alessandro Cicchetti, Federica Palorini, Tiziana Magnani, Valentina Zuco, Marzia Pennati, Elisa Campi, Paola Allavena, Samantha Pesce, Sergio Villa, Barbara Avuzzi, Sara Morlino, Maria Emanuela Visentin, Nadia Zaffaroni, Tiziana Rancati, Riccardo Valdagni
A recent "hot topic" in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy...
2018: Disease Markers
https://www.readbyqxmd.com/read/29675428/ptx3-a-potential-biomarker-in-thyroid-associated-ophthalmopathy
#16
Pei Mou, Ziyu Chen, Lihong Jiang, Jinwei Cheng, Ruili Wei
Background: Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Methods: All studies were performed on TAO patients and healthy controls (45: 28 in total). RNA-seq was used to detect differential gene expression of orbital adipose-connective tissue...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29672566/exogenous-pentraxin-3-inhibits-the-reactive-oxygen-species-mitochondrial-and-apoptosis-pathway-in-acute-kidney-injury
#17
Hyung Ho Lee, Sook Young Kim, Joon Chae Na, Young Eun Yoon, Woong Kyu Han
Pentraxin-3 (PTX3) is a long-form member of the pentraxin family of proteins that has been studied in inflammatory diseases and in various organs. We found that PTX3 protects kidney cells during ischemia and proinflammatory acute kidney injury. The aim of this study was to develop an in vitro experimental model of acute kidney injury and to analyze the protective mechanism of exogenous recombinant PTX3. In this study, cells of the HK-2 renal tubular cell line were treated with a calcium ionophore (A23187), which induced injury by increasing intracellular calcium concentrations and inducing calpain activity and the generation of reactive oxygen species...
2018: PloS One
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#18
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29661181/tlr4-modulates-inflammatory-gene-targets-in-the-retina-during-bacillus-cereus-endophthalmitis
#19
Phillip S Coburn, Frederick C Miller, Austin L LaGrow, Salai Madhumathi Parkunan, C Blake Randall, Rachel L Staats, Michelle C Callegan
BACKGROUND: Endophthalmitis is a serious intraocular infection that frequently results in significant inflammation and vision loss. Because current therapeutics are often unsuccessful in mitigating damaging inflammation during endophthalmitis, more rational targets are needed. Toll-like receptors (TLRs) recognize specific motifs on invading pathogens and initiate the innate inflammatory response. We reported that TLR4 contributes to the robust inflammation which is a hallmark of Bacillus cereus endophthalmitis...
April 16, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29661134/transcriptome-analysis-of-granulosa-cells-after-conventional-vs-long-fsh-induced-superstimulation-in-cattle
#20
F C F Dias, M I R Khan, M A Sirard, G P Adams, J Singh
BACKGROUND: Prolongation of superstimulatory treatment appears to be associated with a greater superovulatory response and with greater oocyte maturation in cattle. A genome-wide bovine oligo-microarray was used to compare the gene expression of granulosa cells collected from ovarian follicles after differing durations of the growing phase induced by exogenous FSH treatment. Cows were given a conventional (4-day) or long (7-day) superstimulatory treatment (25 mg FSH im at 12-h intervals; n = 6 per group), followed by prostaglandin treatment with last FSH and LH treatment 24 h later...
April 16, 2018: BMC Genomics
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