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https://www.readbyqxmd.com/read/29137286/fibroblast-growth-factor-modulates-mast-cell-recruitment-in-a-murine-model-of-prostate-cancer
#1
Roberto Ronca, Roberto Tamma, Daniela Coltrini, Simona Ruggieri, Marco Presta, Domenico Ribatti
Mast cells are important modifiers of prostate tumor microenvironment. The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) system plays a non-redundant autocrine/paracrine role in the growth, vascularization and progression of prostate tumors. Accordingly, the FGF antagonist long pentraxin-3 (PTX3) and the PTX3-derived small molecule FGF-trap NSC12 have been shown to inhibit the growth and vascularization of different FGF-dependent tumor types, including prostate cancer. In this study, we show that recombinant FGF2 is able to cause mast cell recruitment in vivo in the Matrigel plug assay...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131327/cgrp-and-ptx3-as-predictors-of-efficacy-of-onabotulinumtoxin-type-a-in-chronic-migraine-an-observational-study
#2
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
OBJECTIVE: The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). BACKGROUND: OnabotA is an effective treatment in chronic migraine (CM). Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome...
November 13, 2017: Headache
https://www.readbyqxmd.com/read/29123999/inflammation-related-genes-are-upregulated-in-surgical-margins-of-advanced-stage-oral-squamous-cell-carcinoma
#3
Jaijam Suwanwela, Thanaphum Osathanon
Aims: Advanced stage of oral squamous cell carcinoma (OSCC) exhibits different properties compared with the early stage for example an invasion ability. The present study investigated a differential gene expression of surgical margin between advanced and early stage of OSCC. Methods: Gene Expression Omnibus dataset (GSE31056) was downloaded and re-analyzed. Surgical margin samples were categorized into 2 groups; early stage and late stage. Differential gene expression analysis was performed...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29120574/pentraxin-3-genetic-variants-and-the-risk-of-active-pulmonary-tuberculosis
#4
Abeer Sheneef, Mona T Hussein, Tamer Mohamed, Aida A Mahmoud, Laila M Yousef, Ola A Alkady
Tuberculosis is a major health problem worldwide. Genetic factors are considered important determinants of the host susceptibility to Mycobacterium tuberculosis. The aim of the current study was to evaluate the association between pentraxin 3 genetic variants and the susceptibility and severity of active pulmonary tuberculosis. The study included 100 patients with newly diagnosed pulmonary TB and 50 healthy controls. PTX3 plasma level was assayed using ELISA and PTX3 genotypes (rs2305619, rs3816527, rs1840680) were detected by real time PCR in all participants...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119559/preoperative-methylprednisolone-increases-plasma-pentraxin-3-early-after-total-knee-arthroplasty-a-randomized-double-blind-placebo-controlled-trial
#5
V Lindberg-Larsen, H Kehlet, K Pilely, J Bagger, M L Rovsing, P Garred
Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C)...
October 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29079064/wandering-pathways-in-the-regulation-of-innate-immunity-and-inflammation
#6
REVIEW
Alberto Mantovani
Tumor-associated macrophages (TAM) have served as a paradigm of cancer-related inflammation. Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of molecular pathways of innate immunity, in particular cytokines, chemokines and PTX3 as a prototypic fluid phase pattern recognition molecule. Mechanisms of negative regulation are complex and include decoy receptors, receptor antagonists, anti-inflammatory cytokines and the signalling regulator IL-1R8...
October 24, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29051088/update-on-the-role-of-pentraxin-3-in-atherosclerosis-and-cardiovascular-diseases
#7
REVIEW
Matteo Casula, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, Federico Carbone
Pentraxin 3 (PTX3) is an acute-phase protein that was recently demonstrated to play pleiotropic activities in cardiovascular (CV) diseases. Tumor necrosis factor and interleukins up-regulates PTX3 transcription in different cell types (i.e. endothelial cells, phagocytes, smooth muscle cells, fibroblasts and glial cells) involved in atherogenesis. By interacting with numerous ligands, PTX3 acts as a modulatory molecule of complement system, inflammatory response, angiogenesis, and vascular/tissue remodeling...
October 16, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29040878/c-phycocyanin-supplementation-during-in%C3%A2-vitro-maturation-enhances-pre-implantation-developmental-competence-of-parthenogenetic-and-cloned-embryos-in-pigs
#8
Shuang Liang, Jing Guo, Yong Xun Jin, Bao Yuan, Jia-Bao Zhang, Nam-Hyung Kim
C-Phycocyanin (C-PC), a protein from green microalgae, has been suggested to possess various biological activities, including antioxidant and free radical scavenging properties. The aim of the current study was to explore the effects of C-PC on the maturation of porcine oocytes and subsequent developmental competence after parthenogenetic activation and somatic cell nuclear transfer (SCNT) as well as the underlying mechanisms. There was no significant improvement in nuclear maturation rates between the control and C-PC supplementation groups (1, 3, 5, 10 μg/mL)...
September 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#9
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29027216/the-long-pentraxin-ptx3-a-prototypical-sensor-of-tissue-injury-and-a-regulator-of-homeostasis
#10
REVIEW
Marco Erreni, Angelo A Manfredi, Cecilia Garlanda, Alberto Mantovani, Patrizia Rovere-Querini
Tissue damage frequently occurs. The immune system senses it and enforces homeostatic responses that lead to regeneration and repair. The synthesis of acute phase molecules is emerging as a crucial event in this program. The prototypic long pentraxin PTX3 orchestrates the recruitment of leukocytes, stabilizes the provisional matrix in order to facilitate leukocyte and stem progenitor cells trafficking, promotes swift and safe clearance of dying cells and of autoantigens, limiting autoimmunity and protecting the vasculature...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29026413/evaluation-of-pentraxin-3-level-and-its-related-factors-in-patients-undergoing-primary-percutaneous-coronary-intervention
#11
Saeed Alipour-Parsa, Habib Haybar, Mohammad Hasan Namazi, Morteza Safi, Isa Khaheshi, Mehdi Memaryan, Amir Mohammad Eghbalnejad-Mofrad
BACKGROUND: Inflammation has an important role in the development and progression of atherosclerosis, and acute phase proteins such as pentraxin-3 (PTX3) can be deployed in determining the prognosis of coronary artery disease (CAD). So the purpose of this paper was to evaluate the PTX3 level and its related factors in patients undergoing primary percutaneous coronary intervention (PCI). METHODS: In this cross-sectional study, the PTX3 levels were determined for 100 patients with ST-elevation myocardial infarction referred to the Modarres Hospital, Tehran, Iran...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29022895/impairment-of-ptx3-expression-in-osteoblasts-a-key-element-for-osteoporosis
#12
Manuel Scimeca, Antonietta Salustri, Elena Bonanno, Daniela Nardozi, Cecilia Rao, Eleonora Piccirilli, Maurizio Feola, Virginia Tancredi, Annamaria Rinaldi, Giovanni Iolascon, Augusto Orlandi, Elena Gasbarra, Nicola Maffulli, Maria Luisa Brandi, Umberto Tarantino
Pentraxin 3 (PTX3) is a multifunctional glycoprotein regulating inflammatory response, cell proliferation and migration and deposition and remodelling of the extracellular matrix by a variety of cells. In this study, we investigated the possible role of PTX3 in bone homeostasis. To this end, we compared the expression and function of PTX3 in human osteoblasts of osteoporotic, osteoarthritic patients and young subjects not affected by bone diseases. Immunohistochemical analysis performed on bone head biopsies showed a close association between bone health and the number of osteoblasts expressing PTX3...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29020470/diagnostic-value-of-plasma-pentraxin-3-in-acute-appendicitis
#13
Ali Aygun, Burak Katipoglu, Melih Ïmamoglu, Selim Demir, Metin Yadigaroglu, Ozgur Tatli, Selim Yurtsever, Arif Usta, Ahmet Mentese, Suha Turkmen
PURPOSE: To measure serum PTX3 levels in patients admitted with right lower quadrant pain to emergency department and to investigate whether this parameter will be helpful for the diagnosis of acute appendicitis. MATERIALS AND METHODS: This study was conducted with a group of 89 patients over 17 years of age who were admitted with the complaint of right lower quadrant pain to ED and had a preliminary diagnosis of acute appendicitis clinically and the control group of 31 healthy volunteers in a tertiary university hospital for 3 months...
October 11, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29020397/pentraxin-3-gene-polymorphisms-and-pulmonary-aspergillosis-in-copd-patients
#14
Qian He, Hongxing Li, Yuwen Rui, Lulu Liu, Binchan He, Yi Shi, Xin Su
Background: Pentraxin 3 (PTX3) plays an important role in resistance to Aspergillus infections. Previous studies have suggested that PTX3 polymorphisms influence the risk of invasive aspergillosis among transplantation recipients. This study was to investigate the association between PTX3 gene polymorphisms and pulmonary aspergillosis in chronic obstructive pulmonary disease (COPD) population. Methods: We included 173 consecutive inpatients with COPD. 36 cases were finally diagnosed with pulmonary aspergillosis...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28977600/alk2-alk3-bmpr2-acvr2a-mediate-bmp2-induced-downregulation-of-pentraxin-3-expression-in-human-granulosa-lutein-cells
#15
Long Bai, Hsun-Ming Chang, Jung-Chien Cheng, Guiyan Chu, Peter C K Leung, Gongshe Yang
Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined. The aim of this study was to investigate the effect of BMP2 on the regulation of pentraxin 3 (PTX3) expression (the major component of cumulus expansion) and the underlying mechanisms in human granulosa-lutein (hGL) cells. Both primary and immortalized hGL cells were used as research models...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28974948/the-murine-factor-h-related-protein-fhr-b-promotes-complement-activation
#16
Marcell Cserhalmi, Ádám I Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins are described in several species, only human FHRs were functionally investigated. Their biological role is still poorly understood and in part controversial. Recent studies on some of the human FHRs strongly suggest a role for FHRs in enhancing complement activation via competing with FH for binding to certain ligands and surfaces...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28970657/vasopressin-in-septic-shock-assessment-of-sepsis-biomarkers-a-randomized-controlled-trial
#17
Elchin Barzegar, Masoumeh Nouri, Sarah Mousavi, Arezoo Ahmadi, Mojtaba Mojtahedzadeh
BACKGROUND AND AIMS: Vasopressin (VP) in sepsis apart from vasoconstrictive effect may have some immunomodulatory effects. The aim of this study was to evaluate the effect of VP on different aspect of sepsis by measuring of sepsis biomarkers. MATERIALS AND METHODS: In this trial, a total number of 42 septic shock patients were included. The first group received norepinephrine (NE) infusion to reach the target mean arterial pressure (MAP) of ≥ 65 mm Hg and the second group received arginine vasopressin (AVP) infusion in addition to NE...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28966727/identification-of-candidate-genes-associated-with-triple-negative-breast-cancer
#18
Audrey Player, Nissi Abraham, Kayla Burrell, Iria Ondo Bengone, Anthony Harris, Lisa Nunez, Telisa Willaims, Sharon Kwende, Wiley Walls
When triple negative breast cancer (TNBC) are analyzed by gene expression profiling different subclasses are identified, at least one characterized by genes related to immune signaling mechanisms supporting the role of these genes in the cancers. In an earlier study we observed differences in TNBC cell lines with respect to their expression of the cytokine IL32. Our analyses showed that certain cell lines expressed higher levels of the cytokine compared to others. Because TNBC are heterogeneous and immune-related genes appear to play a pivotal role in these cancers, we chose to examine the transcriptomes of the different cell lines based on IL32 expression...
July 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28965650/acute-ethanol-intoxication-suppresses-pentraxin-3-expression-in-a-mouse-sepsis-model-involving-cecal-ligation-and-puncture
#19
Shogo Kasuda, Risa Kudo, Katsuya Yuui, Yoshihiko Sakurai, Katsuhiko Hatake
Acute ethanol intoxication impairs immunological reactions and increases the risk of sepsis; however, the underlying mechanism remains unclear. Pentraxin (PTX) 3 is a humoral pattern recognition receptor whose levels rapidly increase in response to inflammation. PTX3 production is triggered by tumor necrosis factor (TNF)-α and is mediated by c-Jun N-terminal kinase (JNK). As PTX3 exerts protective effects against sepsis as well as acute lung injury, we investigated whether acute ethanol exposure exacerbates sepsis by altering PTX3 expression...
November 2017: Alcohol
https://www.readbyqxmd.com/read/28946774/relationship-between-plasma-pentraxin-3-concentration-and-platelet-indices-in-patients-with-stable-coronary-artery-disease
#20
Ilona Korzonek-Szlacheta, Aleksander Danikiewicz, Janusz Szkodziński, Justyna Nowak, Andrzej Lekston, Mariusz Gąsior, Barbara Zubelewicz-Szkodzińska, Bartosz Hudzik
Few reports have analyzed the effect of pentraxin 3 (PTX3) on platelets and their activation. We explored the association between plasma PTX3 and platelet indices. Forty-nine patients with stable coronary artery disease (CAD) were enrolled. Based on median PTX3, the study population was divided into group 1 (n = 25; PTX3 ≤ 0.98 ng/mL) and group 2 (n = 24; PTX3 > 0.98 ng/mL). Platelet indices investigated included mean platelet volume (MPV), platelet distribution width (PDW), platelets and large cell ratio (P-LCR), MPV to platelet count ratio (MPV/PC), platelet to lymphocyte ratio (PLR), and MPV to lymphocyte ratio (MPVLR)...
January 1, 2017: Angiology
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