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https://www.readbyqxmd.com/read/29319419/in-vivo-and-ex-vivo-inflammatory-markers-of-common-metabolic-phenotypes-in-humans
#1
Rasmus Baadsgaard Mærkedahl, Hanne Frøkiær, Marie Grøntved Stenbæk, Camilla Betak Nielsen, Mads V Lind, Christian Lundtoft, Marietta Boje Bohr, Sabine Ibrügger, Stine Broeng Metzdorff, Henrik Vestergaard, Oluf Pedersen, Lotte Lauritzen
BACKGROUND: Low-grade systemic inflammation (LGSI) is often characterized by elevated levels of interleukin (IL)6, tumor necrosis factor (TNF)α, and C-reactive protein (CRP). Other serum proteins, ex vivo-stimulated cytokine production, and leukocyte count have, however, also been suggested LGSI-markers, but their associations with the metabolic syndrome (MS) are less clear. We aimed to evaluate mutual relationships between in vivo and ex vivo inflammatory markers and their association with MS and its subcomponents...
January 10, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29306659/breast-osteoblast-like-cells-a-reliable-early-marker-for-bone-metastases-from-breast-cancer
#2
Manuel Scimeca, Chiara Antonacci, Nicola Toschi, Elena Giannini, Rita Bonfiglio, Claudio Oreste Buonomo, Chiara Adriana Pistolese, Umberto Tarantino, Elena Bonanno
BACKGROUND: The development of bone metastasis from breast cancer results from a functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of this study was therefore to test the hypothesis that the appearance of breast osteoblast-like cells (BOLCs) in primary mammary lesions is a precursor (and hence an early predictor) of the formation of breast cancer metastases to bone. PATIENTS AND METHODS: In this study, we collected 64 breast infiltrating carcinomas, 50 breast benignant lesions, and 10 biopsies of bone metastasis selected from patients with infiltrated carcinoma...
December 5, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29306404/cerebrospinal-fluid-pentraxin-3-and-cd40-ligand-in-anti-n-menthyl-d-aspartate-receptor-encephalitis
#3
Baozhu Liu, Peiying Ai, Dong Zheng, Ying Jiang, Xiaojia Liu, Suyue Pan, Honghao Wang
Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder of the central nervous system whose pathogenesis involves interleukin (IL)-6 and IL-17A. We examined the correlations between CSF concentrations of the acute-phase protein pentraxin 3 (PTX3), the chronic inflammatory mediator CD40L, IL-6, and IL-17A in anti-NMDAR encephalitis, and the impact on clinical outcome. PTX3, CD40L, IL-6, and IL-17A were significantly higher in the CSF of patients with anti-NMDAR encephalitis than in controls...
February 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29288571/early-second-trimester-maternal-serum-markers-in-prediction-of-gestational-diabetes-mellitus
#4
Baihui Zhao, Xiujun Han, Qing Meng, Qiong Luo
AIMS: To determine whether maternal serum markers in the early-second trimester are useful for prediction of gestational diabetes mellitus (GDM). MATERIALS AND METHODS: A total of 876 singleton pregnancies were recruited in the present study. Blood samples were collected during 16-20 gestational weeks. GDM women were diagnosed by OGTT during 24-28 gestational weeks. Fifty-six cases of GDM and 73 healthy cases were selected. Maternal serum concentrations of placental protein 13 (PP13), pentraxin 3 (PTX3), soluble fms-like tyrosine kinase-1 (sFlt-1), myostatin and follistatin (FST) were detected at 16-20 weeks' gestation...
December 29, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29273304/redundancy-and-robustness-versus-division-of-labour-and-specialization-in-innate-immunity
#5
REVIEW
Alberto Mantovani
Apparent redundancy is a recurrent theme in innate immunity in various domains including inflammatory cytokines, chemokines and pattern recognition receptors. While sharing core function, different mediators may subserve distinct functions related for instance to production and release (e.g. IL-1α versus IL-1β), predominantly local versus systemic function (e.g. PTX3 versus C-reactive protein) or fine tuning of innate and adaptive responses (chemokines). Based on hard-wired phagocyte recruitment and regulation by a wide spectrum of chemokines and conventional or atypical receptors, I argue that trafficking of phagocytic cells is a robust output of the chemokine system, resistant to genetic or environmental variation...
December 19, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29223308/what-we-have-lost-mastitis-resistance-in-holstein-friesians-and-in-a-local-cattle-breed
#6
Giulio Curone, Joel Filipe, Paola Cremonesi, Erminio Trevisi, Massimo Amadori, Claudia Pollera, Bianca Castiglioni, Lauretta Turin, Vittorio Tedde, Daniele Vigo, Paolo Moroni, Andrea Minuti, Valerio Bronzo, M Filippa Addis, Federica Riva
In Holstein Friesian dairy cows, selective pressure for increased milk production has led to a higher propensity to disease, including mastitis, when compared to less selected and lower producing dairy breeds. The biology underpinning the higher resistance to disease of such "local breeds" is not fully understood. With the aim of investigating the factors associated to this phenomenon, we applied a multidisciplinary approach to compare innate immune response patterns, metabolic parameters, milk protein profiles and the milk microbiota in Holstein Friesian and Rendena cows reared in the same farm and under the same management conditions...
November 29, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29202702/c-reactive-protein-crp-but-not-the-related-pentraxins-serum-amyloid-p-and-ptx3-inhibits-the-proliferation-and-induces-apoptosis-of-the-leukemia-cell-line-mono-mac-6
#7
Wensheng Chen, Darrell Pilling, Richard H Gomer
BACKGROUND: Pentraxins are a family of highly conserved secreted proteins that regulate the innate immune system, including monocytes and macrophages. C-reactive protein (CRP) is a plasma protein whose levels can rise to 1000 μg/ml from the normal <3 μg/ ml during inflammation. RESULTS: We find that CRP inhibits proliferation of the human myeloid leukemia cell line Mono Mac 6 with an IC50 of 75 μg/ ml by inducing apoptosis of these cells. The related proteins serum amyloid P (SAP) and pentraxin 3 (PTX3) do not inhibit Mono Mac 6 proliferation...
December 4, 2017: BMC Immunology
https://www.readbyqxmd.com/read/29193454/amniotic-fluid-pentraxins-potential-early-markers-for-identifying-intra-amniotic-inflammatory-complications-in-preterm-pre-labor-rupture-of-membranes
#8
Ivana Musilova, Ctirad Andrys, Jan Krejsek, Marcela Drahosova, Barbora Zednikova, Lenka Pliskova, Helena Zemlickova, Bo Jacobsson, Marian Kacerovsky
In this study, pentraxin 3 (PTX3), C-reactive protein (CRP), and serum amyloid P component (SAP) concentrations in the amniotic fluid of women with preterm pre-labor rupture of membranes (PPROM) were evaluated based on evidence of microbial invasion of the amniotic cavity (MIAC), intra-amniotic inflammation (IAI), and microbial-associated IAI. A total of 149 women with PPROM were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis. Amniotic fluid PTX3, SAP, and CRP concentrations were assessed using enzyme-linked immunosorbent assay...
November 28, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29175552/long-pentraxin-3-a-novel-multifaceted-player-in-cancer
#9
REVIEW
Arianna Giacomini, Gaia Cristina Ghedini, Marco Presta, Roberto Ronca
Since its discovery in 1992, long pentraxin 3 (PTX3) has been characterized as soluble patter recognition receptor, a key player of the innate immunity arm with non-redundant functions in pathogen recognition and inflammatory responses. As a component of the extra-cellular matrix milieu, PTX3 has been implicated also in wound healing/tissue remodeling, cardiovascular diseases, fertility, and infectious diseases. Consequently, PTX3 levels in biological fluids have been proposed as a fluid-phase biomarker in different pathological conditions...
November 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29137286/fibroblast-growth-factor-modulates-mast-cell-recruitment-in-a-murine-model-of-prostate-cancer
#10
Roberto Ronca, Roberto Tamma, Daniela Coltrini, Simona Ruggieri, Marco Presta, Domenico Ribatti
Mast cells are important modifiers of prostate tumor microenvironment. The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) system plays a non-redundant autocrine/paracrine role in the growth, vascularization and progression of prostate tumors. Accordingly, the FGF antagonist long pentraxin-3 (PTX3) and the PTX3-derived small molecule FGF-trap NSC12 have been shown to inhibit the growth and vascularization of different FGF-dependent tumor types, including prostate cancer. In this study, we show that recombinant FGF2 is able to cause mast cell recruitment in vivo in the Matrigel plug assay...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131327/cgrp-and-ptx3-as-predictors-of-efficacy-of-onabotulinumtoxin-type-a-in-chronic-migraine-an-observational-study
#11
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
OBJECTIVE: The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). BACKGROUND: OnabotA is an effective treatment in chronic migraine (CM). Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome...
November 13, 2017: Headache
https://www.readbyqxmd.com/read/29123999/inflammation-related-genes-are-upregulated-in-surgical-margins-of-advanced-stage-oral-squamous-cell-carcinoma
#12
Jaijam Suwanwela, Thanaphum Osathanon
Aims: Advanced stage of oral squamous cell carcinoma (OSCC) exhibits different properties compared with the early stage for example an invasion ability. The present study investigated a differential gene expression of surgical margin between advanced and early stage of OSCC. Methods: Gene Expression Omnibus dataset (GSE31056) was downloaded and re-analyzed. Surgical margin samples were categorized into 2 groups; early stage and late stage. Differential gene expression analysis was performed...
September 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29120574/pentraxin-3-genetic-variants-and-the-risk-of-active-pulmonary-tuberculosis
#13
Abeer Sheneef, Mona T Hussein, Tamer Mohamed, Aida A Mahmoud, Laila M Yousef, Ola A Alkady
Tuberculosis is a major health problem worldwide. Genetic factors are considered important determinants of the host susceptibility to Mycobacterium tuberculosis. The aim of the current study was to evaluate the association between pentraxin 3 genetic variants and the susceptibility and severity of active pulmonary tuberculosis. The study included 100 patients with newly diagnosed pulmonary TB and 50 healthy controls. PTX3 plasma level was assayed using ELISA and PTX3 genotypes (rs2305619, rs3816527, rs1840680) were detected by real time PCR in all participants...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119559/preoperative-methylprednisolone-increases-plasma-pentraxin-3-early-after-total-knee-arthroplasty-a-randomized-double-blind-placebo-controlled-trial
#14
V Lindberg-Larsen, H Kehlet, K Pilely, J Bagger, M L Rovsing, P Garred
Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C)...
October 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29079064/wandering-pathways-in-the-regulation-of-innate-immunity-and-inflammation
#15
REVIEW
Alberto Mantovani
Tumor-associated macrophages (TAM) have served as a paradigm of cancer-related inflammation. Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of molecular pathways of innate immunity, in particular cytokines, chemokines and PTX3 as a prototypic fluid phase pattern recognition molecule. Mechanisms of negative regulation are complex and include decoy receptors, receptor antagonists, anti-inflammatory cytokines and the signalling regulator IL-1R8...
October 24, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29051088/update-on-the-role-of-pentraxin-3-in-atherosclerosis-and-cardiovascular-diseases
#16
REVIEW
Matteo Casula, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Franco Dallegri, Federico Carbone
Pentraxin 3 (PTX3) is an acute-phase protein that was recently demonstrated to play pleiotropic activities in cardiovascular (CV) diseases. Tumor necrosis factor and interleukins up-regulates PTX3 transcription in different cell types (i.e. endothelial cells, phagocytes, smooth muscle cells, fibroblasts and glial cells) involved in atherogenesis. By interacting with numerous ligands, PTX3 acts as a modulatory molecule of complement system, inflammatory response, angiogenesis, and vascular/tissue remodeling...
October 16, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29040878/c-phycocyanin-supplementation-during-in%C3%A2-vitro-maturation-enhances-pre-implantation-developmental-competence-of-parthenogenetic-and-cloned-embryos-in-pigs
#17
Shuang Liang, Jing Guo, Yong Xun Jin, Bao Yuan, Jia-Bao Zhang, Nam-Hyung Kim
C-Phycocyanin (C-PC), a protein from green microalgae, has been suggested to possess various biological activities, including antioxidant and free radical scavenging properties. The aim of the current study was to explore the effects of C-PC on the maturation of porcine oocytes and subsequent developmental competence after parthenogenetic activation and somatic cell nuclear transfer (SCNT) as well as the underlying mechanisms. There was no significant improvement in nuclear maturation rates between the control and C-PC supplementation groups (1, 3, 5, 10 μg/mL)...
September 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#18
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29027216/the-long-pentraxin-ptx3-a-prototypical-sensor-of-tissue-injury-and-a-regulator-of-homeostasis
#19
REVIEW
Marco Erreni, Angelo A Manfredi, Cecilia Garlanda, Alberto Mantovani, Patrizia Rovere-Querini
Tissue damage frequently occurs. The immune system senses it and enforces homeostatic responses that lead to regeneration and repair. The synthesis of acute phase molecules is emerging as a crucial event in this program. The prototypic long pentraxin PTX3 orchestrates the recruitment of leukocytes, stabilizes the provisional matrix in order to facilitate leukocyte and stem progenitor cells trafficking, promotes swift and safe clearance of dying cells and of autoantigens, limiting autoimmunity and protecting the vasculature...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29026413/evaluation-of-pentraxin-3-level-and-its-related-factors-in-patients-undergoing-primary-percutaneous-coronary-intervention
#20
Saeed Alipour-Parsa, Habib Haybar, Mohammad Hasan Namazi, Morteza Safi, Isa Khaheshi, Mehdi Memaryan, Amir Mohammad Eghbalnejad-Mofrad
BACKGROUND: Inflammation has an important role in the development and progression of atherosclerosis, and acute phase proteins such as pentraxin-3 (PTX3) can be deployed in determining the prognosis of coronary artery disease (CAD). So the purpose of this paper was to evaluate the PTX3 level and its related factors in patients undergoing primary percutaneous coronary intervention (PCI). METHODS: In this cross-sectional study, the PTX3 levels were determined for 100 patients with ST-elevation myocardial infarction referred to the Modarres Hospital, Tehran, Iran...
March 2017: ARYA Atherosclerosis
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