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Metabolic disorder complications and Diabetes type II

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https://www.readbyqxmd.com/read/27669970/intestinal-dysbiosis-gut-hyperpermeability-and-bacterial-translocation-missing-links-between-depression-obesity-and-type-2-diabetes
#1
Anastasiya Slyepchenko, Michael Maes, Rodrigo Machado-Veira, George Anderson, Marco Solmi, Yolanda Sanz, Michael Berk, Cristiano A Köhler, André F Carvalho
The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction...
September 22, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27536242/azilsartan-as-a-potent-antihypertensive-drug-with-possible-pleiotropic-cardiometabolic-effects-a-review-study
#2
REVIEW
Georgios Georgiopoulos, Vasiliki Katsi, Dimitrios Oikonomou, Georgia Vamvakou, Evangelia Koutli, Aggeliki Laina, Constantinos Tsioufis, Petros Nihoyannopoulos, Dimitrios Tousoulis
BACKGROUND: Hypertension related cardiovascular (CV) complications could be amplified by the presence of metabolic co-morbidities. Azilsartan medoxomil (AZL-M) is the eighth approved member of angiotensin II receptor blockers (ARBs), a drug class of high priority in the management of hypertensive subjects with diabetes mellitus type II (DMII). METHODS: Under this prism, we performed a systematic review of the literature for all relevant articles in order to evaluate the efficacy, safety, and possible clinical role of AZL-M in hypertensive diabetic patients...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27535259/does-diabetes-mellitus-affect-tendon-healing
#3
Aisha Siddiqah Ahmed
Diabetes mellitus (DM) is a metabolic disorder resulting from defective insulin production and characterized by chronic hyperglycemia. DM affects around 170 million people worldwide and its incidence is increasing globally. DM can cause a wide range of musculoskeletal disorders such as painful tendinopathies, tendon contracture, tendon rupture, and rotator cuff tear.In patients with diabetes neuropathy, diminished peripheral blood flow and decreased local angiogenesis are reported which probably are results of abnormalities in the production of collagen production, inflammatory mediators, angiogenic and growth factors and also contribute to lack of healing in damaged tissue...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26924459/vascular-calcification-in-type-2-diabetes-and-cardiovascular-disease-integrative-roles-for-opg-rankl-and-trail
#4
REVIEW
Emma Harper, Hannah Forde, Colin Davenport, Keith D Rochfort, Diarmuid Smith, Philip M Cummins
Vascular calcification (VC), a disorder that causes blood vessel hardening and dysfunction, is a significant risk factor for type-2 diabetes mellitus (T2DM), which invariably manifests associated cardiovascular complications. Although the clinical effects of VC have been well-documented, the precise cellular events underlying the manifestation and progression of VC are only now coming to light. Current research models indicate that VC likely involves signalling pathways traditionally associated with bone remodelling, such as the OPG/RANKL/TRAIL signalling system...
July 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/26857927/evidences-for-diabetes-and-insulin-mimetic-activity-of-medicinal-plants-present-status-and-future-prospects
#5
H M Manukumar, J Shiva Kumar, B Chandrashekar, Sri Raghava, S Umesha
Diabetes mellitus (DM) is a considerable systemic metabolic disorder to exhibit various metabolic and cardiovascular disorders, mainly hyperglycemia. The global projected estimate of diabetes in 2030 will be about 439 million adults, out of which 300 million expected are of type-2 diabetes mellitus (T2DM). The present knowledge revealed responsible factors, occurrence and mechanism of these factors involved in the DM diseases. Hence, the aim of this review is to address and summaries the causes, plant resources, importance, present status and future programmes for diabetes control...
February 8, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/26786774/effects-of-dietary-phosphate-on-glucose-and-lipid-metabolism
#6
Maerjianghan Abuduli, Hirokazu Ohminami, Tamaki Otani, Hitoshi Kubo, Haruka Ueda, Yoshichika Kawai, Masashi Masuda, Hisami Yamanaka-Okumura, Hiroshi Sakaue, Hironori Yamamoto, Eiji Takeda, Yutaka Taketani
Recent epidemiological and animal studies have suggested that excess intake of phosphate (Pi) is a risk factor for the progression of chronic kidney disease and its cardiovascular complications. However, little is known about the impact of dietary high Pi intake on the development of metabolic disorders such as obesity and type 2 diabetes. In this study, we investigated the effects of dietary Pi on glucose and lipid metabolism in healthy rats. Male 8-wk-old Sprague-Dawley rats were divided into three groups and given experimental diets containing varying amounts of Pi, i...
April 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26773012/potential-of-dietary-non-provitamin-a-carotenoids-in-the-prevention-and-treatment-of-diabetic-microvascular-complications
#7
REVIEW
Ana Gabriela Murillo, Maria Luz Fernandez
Diabetes is a chronic metabolic disease that affects a substantial part of the population around the world. Whether type I or type II, this disease has serious macro- and microvascular complications that constitute the primary cause of death in diabetic patients. Microvascular complications include diabetic retinopathy, nephropathy, and neuropathy. Although these complications are clinically and etiologically diverse, they share a common factor: glucose-induced damage. In the progression of diabetic complications, oxidative stress, inflammation, and the formation of glycation end products play an important role...
January 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/26403978/thrombosis-during-pregnancy-risks-prevention-and-treatment-for-mother-and-fetus-harvesting-the-power-of-omic-technology-biomarkers-and-in-vitro-or-in-vivo-models-to-facilitate-the-treatment-of-thrombosis
#8
REVIEW
Sara Ornaghi, Martin Mueller, Eytan R Barnea, Michael J Paidas
Maternal thromboembolism and a spectrum of placenta-mediated complications including the pre-eclampsia syndromes, fetal growth restriction, fetal loss, and abruption manifest a shared etiopathogenesis and predisposing risk factors. Furthermore, these maternal and fetal complications are often linked to subsequent maternal health consequences that comprise the metabolic syndrome, namely, thromboembolism, chronic hypertension, and type II diabetes. Traditionally, several lines of evidence have linked vasoconstriction, excessive thrombosis and inflammation, and impaired trophoblast invasion at the uteroplacental interface as hallmark features of the placental complications...
September 2015: Birth Defects Research. Part C, Embryo Today: Reviews
https://www.readbyqxmd.com/read/26358774/insulin-response-dysregulation-explains-abnormal-fat-storage-and-increased-risk-of-diabetes-mellitus-type-2-in-cohen-syndrome
#9
Floriane Limoge, Laurence Faivre, Thomas Gautier, Jean-Michel Petit, Elodie Gautier, David Masson, Gaëtan Jego, Salima El Chehadeh-Djebbar, Nathalie Marle, Virginie Carmignac, Valérie Deckert, Marie-Claude Brindisi, Patrick Edery, Jamal Ghoumid, Edward Blair, Laurent Lagrost, Christel Thauvin-Robinet, Laurence Duplomb
Cohen Syndrome (CS) is a rare autosomal recessive disorder, with defective glycosylation secondary to mutations in the VPS13B gene, which encodes a protein of the Golgi apparatus. Besides congenital neutropenia, retinopathy and intellectual deficiency, CS patients are faced with truncal obesity. Metabolism investigations showed abnormal glucose tolerance tests and low HDL values in some patients, and these could be risk factors for the development of diabetes mellitus and/or cardiovascular complications. To understand the mechanisms involved in CS fat storage, we used two models of adipogenesis differentiation: (i) SGBS pre-adipocytes with VPS13B invalidation thanks to siRNA delivery and (ii) CS primary fibroblasts...
December 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/26033221/zucker-diabetic-fatty-rats-a-model-for-type-2-diabetes-develop-an-inner-ear-dysfunction-that-can-be-attenuated-by-losartan-treatment
#10
Angela-Maria Meyer zum Gottesberge, Thomas Massing, Anja Sasse, Silvia Palma, Stefan Hansen
Hearing loss secondary to diabetes remains under debate. In our study, we used Zucker Diabetic Fatty (ZDF) rats as an animal model of type 2 diabetes to investigate whether (1) hearing ability impairment and structural alterations of the inner ear occur in diabetes and (2) an angiotensin II receptor blocker (losartan) can protect rats from diabetic damage. Homozygous mutants were treated with a placebo or losartan and heterozygous animals served as non-diabetic controls. All animals underwent immunohistochemical and electronmicroscopical analysis...
November 2015: Cell and Tissue Research
https://www.readbyqxmd.com/read/25217232/calcium-signalling-in-diabetes
#11
REVIEW
Agustin Guerrero-Hernandez, Alexei Verkhratsky
Molecular cascades responsible for Ca(2+) homeostasis and Ca(2+) signalling could be assembled in highly plastic toolkits that define physiological adaptation of cells to the environment and which are intimately involved in all types of cellular pathology. Control over Ca(2+) concentration in different cellular compartments is intimately linked to cell metabolism, because (i) ATP production requires low Ca(2+), (ii) Ca(2+) homeostatic systems consume ATP and (iii) Ca(2+) signals in mitochondria stimulate ATP synthesis being an essential part of excitation-metabolic coupling...
November 2014: Cell Calcium
https://www.readbyqxmd.com/read/25023888/glp-1-receptor-agonist-liraglutide-reverses-long-term-atypical-antipsychotic-treatment-associated-behavioral-depression-and-metabolic-abnormalities-in-rats
#12
Ajaykumar N Sharma, Sagar S Ligade, Jay N Sharma, Praveen Shukla, Khalid M Elased, James B Lucot
Mood disorder patients that are on long-term atypical antipsychotics treatment frequently experience metabolic dysfunctions. In addition to this, accumulating evidences points to increased risk of structural abnormalities, brain volume changes, altered neuroplasticity and behavioral depression with long-term antipsychotics use. However, there is paucity of preclinical evidences for long-term antipsychotic associated depression-like behavior. The objectives of the present study were: (1) to evaluate influence of long-term antipsychotic (olanzapine) treatment on rat behavior in forced swim test (FST) as a model for depression and; (2) to examine impact of glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide - an antidiabetic medication for type II diabetes, on long-term olanzapine associated metabolic and behavioral changes in rats...
April 2015: Metabolic Brain Disease
https://www.readbyqxmd.com/read/25001669/the-effects-of-electrical-stimulation-on-body-composition-and-metabolic-profile-after-spinal-cord-injury-part-ii
#13
REVIEW
Ashraf S Gorgey, David R Dolbow, James D Dolbow, Refka K Khalil, David R Gater
Diet and exercise are cornerstones in the management of obesity and associated metabolic complications, including insulin resistance, type 2 diabetes, and disturbances in the lipid profile. However, the role of exercise in managing body composition adaptations and metabolic disorders after spinal cord injury (SCI) is not well established. The current review summarizes evidence about the efficacy of using neuromuscular electrical stimulation or functional electrical stimulation in exercising the paralytic lower extremities to improve body composition and metabolic profile after SCI...
January 2015: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/24974749/-live-style-and-risk-of-lifestyle-diseases
#14
Jan Kábrt
Metabolic syndrome included obesity, diabetes mellitus type II, hypertension and disorder of lipid metabolism are serious complication affecting many people of economic advanced countries. Unhealthy live style with limited physical activity and overfeeding are the main cause of this disorder. Adjustment of the live style with regular physical activity has the better result compared with a diet intervention alone.
May 2014: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/24843435/report-of-the-committee-on-the-classification-and-diagnostic-criteria-of-diabetes-mellitus
#15
Yutaka Seino, Kishio Nanjo, Naoko Tajima, Takashi Kadowaki, Atsunori Kashiwagi, Eiichi Araki, Chikako Ito, Nobuya Inagaki, Yasuhiko Iwamoto, Masato Kasuga, Toshiaki Hanafusa, Masakazu Haneda, Kohjiro Ueki
Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long-term persistence of metabolic disorders can cause susceptibility to specific complications and also foster arteriosclerosis. Diabetes mellitus is associated with a broad range of clinical presentations, from being asymptomatic to ketoacidosis or coma, depending on the degree of metabolic disorder...
October 19, 2010: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/24564669/the-effect-of-n-3-fatty-acids-on-glucose-homeostasis-and-insulin-sensitivity
#16
REVIEW
P Flachs, M Rossmeisl, J Kopecky
Type 2 diabetes (T2D) as well as cardiovascular disease (CVD) represent major complications of obesity and associated metabolic disorders (metabolic syndrome). This review focuses on the effects of long-chain n-3 polyunsaturated fatty acids (omega-3) on insulin sensitivity and glucose homeostasis, which are improved by omega-3 in many animal models of metabolic syndrome, but remain frequently unaffected in humans. Here we focus on: (i) mechanistic aspects of omega-3 action, reflecting also our experiments in dietary obese mice; and (ii) recent studies analysing omega-3's effects in various categories of human subjects...
2014: Physiological Research
https://www.readbyqxmd.com/read/24355557/investigating-gstt1-and-gstm1-null-genotype-as-the-risk-factor-of-diabetes-type-2-retinopathy
#17
Alamdar Dadbinpour, Mohammad Hasan Sheikhha, Mojtaba Darbouy, Mohammad Afkhami-Ardekani
BACKGROUND: Diabetes is one of the multifactorial disorders with genetics and environmental factors playing important role in its cause. In diabetes, the defects in cellular metabolism results in increasing free radicals. These radicals react with other vital cellular molecules which are responsible in diabetes side effects. Human glutathione S-transferases (GST) are a family of enzymes that catalyses conjugation of electrophilic substances with glutathione. In this research the deletion of two of the most important genes of this family; GSTT1 and GSTM1 genes was investigated as the risk factor for diabetes mellitus type II and one of its most important complications; retinopathy...
2013: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/24249932/prevalence-of-depression-in-patients-with-type-ii-diabetes-mellitus-and-its-impact-on-quality-of-life
#18
Ranjan Das, Omprakash Singh, Rajarshi Guha Thakurta, M R Khandakar, S N Ali, Asim Kumar Mallick, Paromita Roy, Amit K Bhattacharrya
BACKGROUND: Diabetes mellitus (DM) is a frequently encountered chronic metabolic disease with various complications throughout its course, which causes severe restriction and disability in an individual's life. It has been well documented that the incidence of depression is higher in diabetic patients and co-morbid depression causes further deterioration in the quality of life in diabetic patients. AIMS: To study the prevalence of depression and its impact on quality of life in patients with type II DM...
July 2013: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/24217609/angiogenesis-as-a-therapeutic-target-for-obesity-and-metabolic-diseases
#19
REVIEW
Yihai Cao
White adipose tissue constantly experiences expansion and shrinkage during the entire adulthood, depending on the metabolic status of the host. Emerging evidence demonstrates that the plasticity of white adipose tissue is tightly controlled by the adipose vasculature, which may grow or regress to coordinate adipose tissue metabolism. In metabolically active brown adipose tissue, an exceedingly high density of blood vessels may perfuse oxygen for energy consumption. Consequently, modulation of vascular density and functions in both white adipose tissue and brown adipose tissue may offer an exciting opportunity for therapeutic interference of obesity and metabolic disease...
2014: Chemical Immunology and Allergy
https://www.readbyqxmd.com/read/24075080/entropy-analysis-of-muscular-near-infrared-spectroscopy-nirs-signals-during-exercise-programme-of-type-2-diabetic-patients-quantitative-assessment-of-muscle-metabolic-pattern
#20
Filippo Molinari, U Rajendra Acharya, Roshan Joy Martis, Riccardo De Luca, Giuliana Petraroli, William Liboni
Diabetes mellitus (DM) is a metabolic disorder that is widely rampant throughout the world population these days. The uncontrolled DM may lead to complications of eye, heart, kidney and nerves. The most common type of diabetes is the type 2 diabetes or insulin-resistant DM. Near-infrared spectroscopy (NIRS) technology is widely used in non-invasive monitoring of physiological signals. Three types of NIRS signals are used in this work: (i) variation in the oxygenated haemoglobin (O2Hb) concentration, (ii) deoxygenated haemoglobin (HHb), and (iii) ratio of oxygenated over the sum of the oxygenated and deoxygenated haemoglobin which is defined as: tissue oxygenation index (TOI) to analyze the effect of exercise on diabetes subjects...
December 2013: Computer Methods and Programs in Biomedicine
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