Sung-Hwan Kim, In-Chul Lee, Hyung-Seon Baek, Kyeong-Woo No, Dong-Ho Shin, Changjong Moon, Sung-Ho Kim, Seung-Chun Park, Jong-Choon Kim
After the outbreak of acute renal failure associated with melamine-contaminated pet food, melamine and melamine-related compounds have become of great interest from a toxicologic perspective. We investigated the potential effects of melamine in combination with cyanuric acid (M + CA, 1:1) on pregnant dams and embryo-fetal development in rats. M + CA was orally administered to pregnant rats from gestational days 6 through 19 at doses of 0, 3, 10, and 30 mg/kg/day of both melamine and cyanuric acid. Maternal toxicity of rats administered 30 mg/kg/day M + CA was manifested as increased incidences of clinical signs and death; gross pathologic findings; higher blood urea nitrogen and creatinine levels; lower body weight gain and food intake; decreased thymus weight; and increased heart, lung, and kidney weights...
October 2013: Birth Defects Research. Part B, Developmental and Reproductive Toxicology