keyword
MENU ▼
Read by QxMD icon Read
search

HPA axis

keyword
https://www.readbyqxmd.com/read/29684711/hypothalamic-pituitary-adrenal-axis-activity-in-the-comorbidity-between-obsessive-compulsive-disorder-and-major-depression
#1
Javier Labad, Virginia Soria, Neus Salvat-Pujol, Cinto Segalàs, Eva Real, Mikel Urretavizcaya, Aida de Arriba-Arnau, Alex Ferrer, José M Crespo, Susana Jiménez-Murcia, Carles Soriano-Mas, Pino Alonso, José M Menchón
Major depressive disorder (MDD) is the most common psychiatric comorbidity in patients with obsessive-compulsive disorder (OCD). Hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been described in both disorders and might play a role in the association between them. We aimed to study the role of HPA axis activity in the comorbidity between OCD and MDD, while controlling for psychopathological dimensions such as anxiety and depressive symptoms. We studied 324 participants belonging to four diagnostic groups: 1) MDD (n = 101), 2) OCD with comorbid MDD (n = 33), 3) OCD without MDD (n = 52), and 4) healthy subjects (n = 138)...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29682808/stress-alcohol-and-infection-during-early-development-a-brief-review-of-common-outcomes-and-mechanisms
#2
REVIEW
Pablo Nicolás Surkin, Heather Brenhouse, Terrence Deak, Ana Clara Liberman, Mercedes Lasaga
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during early stages of life such as infancy or adolescence can induce adaptations in multiple physiological systems, including the reproductive axis (HPG), the hypothalamic-pituitary-adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioral responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (peri-natal, juvenile, adolescent periods) and how developmental timing of early life stress confers unique physiological adaptations that may persist across the lifespan...
April 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29681219/antidepressant-like-effects-of-embelin-and-its-possible-mechanisms-of-action-in-chronic-unpredictable-stress-induced-mice
#3
Bailing Wang, Xiaoqin Chen, Tiantian Zhou, Xiaoying Wang
Objectives Embelin, a principal active constituent of embelin ribes burm, has good therapeutic effects on various diseases. To explore the effects and underlying mechanisms of embelin on depression, we made a preliminary study to clarify this issue. Methods We first used chronic unpredictable stress (CUS) to construct the model of depression in mice. Then, we determined the effects of embelin on CUS-induced behavioral dysfunction using open field test, sucrose preference test, tail suspension test and forced swimming test...
April 21, 2018: Neurological Research
https://www.readbyqxmd.com/read/29680774/targeting-hypothalamic-pituitary-adrenal-axis-hormones-and-sex-steroids-for-improving-cognition-in-major-mood-disorders-and-schizophrenia-a-systematic-review-and-narrative-synthesis
#4
REVIEW
Virginia Soria, Alexandre González-Rodríguez, Elena Huerta-Ramos, Judith Usall, Jesús Cobo, Miquel Bioque, Juan David Barbero, Clemente García-Rizo, Meritxell Tost, José Antonio Monreal, Javier Labad
Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia, major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of functional disability. There is limited efficacy of pharmacological interventions for improving the cognitive deficits in these disorders. As pro-cognitive pharmacological treatments are lacking, hormones or drugs that target the endocrine system may become potential candidates for 'repurposing' trials aiming to improve cognition. We aimed to study whether treatment with drugs targeting the hypothalamic-pituitary-adrenal (HPA) axis and sex steroids can improve cognition in patients with schizophrenia, MDD or BD...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29679879/polygenic-risk-score-of-serpina6-serpina1-associates-with-diurnal-and-stress-induced-hpa-axis-activity-in-children
#5
Siddheshwar Utge, Katri Räikkönen, Eero Kajantie, Jari Lipsanen, Sture Andersson, Timo Strandberg, Rebecca M Reynolds, Johan G Eriksson, Jari Lahti
PURPOSE: Corticosteroid-binding globulin (CBG) transports glucocorticoids in blood. Variation in genes SERPINA6 encoding for CBG, SERPINA2 and SERPINA1 (serpin family A member 6, 2, and 1) have been shown to influence morning plasma cortisol and CBG in adults. However, association of this genetic variation with diurnal and stress-induced salivary cortisol remain unknown. This study aims to investigate the effect of genetic variation in SERPINA6/2/1 loci on diurnal and stress-induced salivary cortisol in children...
April 13, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29679646/chronic-methamphetamine-exposure-attenuates-neural-activation-in-hypothalamic-pituitary-adrenal-axis-associated-brain-regions-in-a-sex-specific-manner
#6
Jason S Jacobskind, Zachary J Rosinger, Tiffany Gonzalez, Kristen L Zuloaga, Damian G Zuloaga
Sex differences in methamphetamine (MA) abuse and consequences of MA have been reported with females showing an increased addiction phenotype and withdrawal symptoms. One mechanism through which these effects might occur is via sex-specific alterations in the hypothalamic-pituitary-adrenal (HPA) axis and its associated brain regions. In this study, mice were administered MA (5 mg/kg) or saline for 10 consecutive days. During early withdrawal, anxiety-like behaviors were assessed in the open field, light/dark box, and elevated plus maze...
April 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29679067/psychological-stress-deteriorates-skin-barrier-function-by-activating-11%C3%AE-hydroxysteroid-dehydrogenase-1-and-the-hpa-axis
#7
Sung Jay Choe, Donghye Kim, Eun Jung Kim, Joung-Sook Ahn, Eun-Jeong Choi, Eui Dong Son, Tae Ryong Lee, Eung Ho Choi
Psychological stress (PS) increases endogenous glucocorticoids (GC) by activating the hypothalamic-pituitary-adrenal axis. The negative effects of GC on skin barrier function under PS have been well-established. However, endogenous GC can also be active when cortisone (inactive form) is converted to cortisol (active form) by 11β-hydroxysteroid dehydrogenase type I (11ß-HSD1) in the peripheral tissue. Here, we evaluated the changes in 11ß-HSD1 and barrier function under PS. Elevated 11ß-HSD1 in oral mucosa correlated with increased cortisol in the stratum corneum and deteriorated barrier function...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29673237/panax-notoginseng-saponins-a-review-of-its-mechanisms-of-antidepressant-or-anxiolytic-effects-and-network-analysis-on-phytochemistry-and-pharmacology
#8
REVIEW
Weijie Xie, Xiangbao Meng, Yadong Zhai, Ping Zhou, Tianyuan Ye, Zhen Wang, Guibo Sun, Xiaobo Sun
Panax notoginseng (Burk) F. H. Chen , as traditional Chinese medicine, has a long history of high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose and blood pressure, inhibition of neuronal apoptosis, and neuronal protection, and its main ingredients are Panax notoginseng saponins (PNS). Currently, Panax notoginseng (Burk) F. H. Chen may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation...
April 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29663559/sex-differences-in-hippocampal-mineralocorticoid-and-glucocorticoid-receptor-mrna-expression-in-response-to-acute-mate-pair-separation-in-zebra-finches-taeniopygia-guttata
#9
Farrah N Madison, Andrew J Kesner, Beau A Alward, Gregory F Ball
Mate separation has been shown to mediate changes in physiological and behavioral processes via activation of the hypothalamo-pituitary-adrenal (HPA) axis in both mammalian and avian species. In order to elucidate the neural mechanisms associated with changes in the HPA axis in response to social stress, we investigated the effects of mate pair separation on circulating corticosterone concentrations as well as gene expression levels of mineralocorticoid receptor (MR), glucocorticoid receptor (GR), and corticotropin releasing hormone (CRH) in the hypothalamus and hippocampus of both male and female zebra finches, a species that forms strong pair bonds...
April 16, 2018: Hippocampus
https://www.readbyqxmd.com/read/29661486/pre-encoding-stress-induced-changes-in-perceived-stress-blood-pressure-and-cortisol-are-differentially-associated-with-recollection-and-familiarity
#10
Uta S Wiemers, Tanja C Hamacher-Dang, Andrew P Yonelinas, Oliver T Wolf
Stress before encoding is often linked to impaired memory. Further influences of stress on memory are arousal of the to be learned material and memory retrieval type (free recall vs. recognition). In the current study we tested the influence of stress on memory encoding for neutral and negative arousing pictures in healthy young adults. A total of 80 participants (40 men) were subjected either to the socially evaluated cold pressure test or a control condition before encoding of arousing and neutral pictures...
April 13, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29656044/state-of-the-art-knowledge-in-adrenocortical-and-behavioral-responses-to-environmental-challenges-in-a-threatened-south-american-ratite-implications-to-in-situ-and-ex-situ-conservation
#11
REVIEW
Navarro Joaquín Luis, Alvina Lèche, Natalia S Della Costa, Marilina Vera Cortez, Raúl H Marin, Mónica B Martella
The Greater Rhea (Rhea americana) is an endemic ratite to South America, whose wild populations have undergone a remarkable decrease due to habitat degradation and fragmentation by the expansion of the agricultural frontier, poaching and predation by dogs. Anthropogenic perturbations in wild environments, as well as the management in captivity, can generate different stress responses in this species, thus, the monitoring of adrenocortical and behavioral activities are considered primary assessment tools with both conservation and welfare implications...
April 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#12
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29651676/essence-of-shen-kidney-controlling-bones-conceptual-analysis-based-on-hypothalamic-pituitary-adrenal-osteo-related-cells-axis
#13
Tao-Tao Xu, Hong-Ting Jin, Pei-Jian Tong
As a traditional concept of Chinese medicine (CM), the theory of "Shen (Kidney) controlling bones" has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen defifi ciency as a pathological condition has a negative effect on the skeleton of body, specififi cally the disorder of bone homeostasis. Present studies indicate that Shen defifi ciency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal (HPA) axis...
April 12, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29650294/increased-methylation-at-an-unexplored-glucocorticoid-responsive-element-within-exon-1-d-of-nr3c1-gene-is-related-to-anxious-depressive-disorders-and-decreased-hippocampal-connectivity
#14
Helena Palma-Gudiel, Aldo Córdova-Palomera, Cristian Tornador, Carles Falcón, Núria Bargalló, Gustavo Deco, Lourdes Fañanás
Among the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities. Methylation at the exon 1F of the glucocorticoid receptor gene NR3C1 has been associated with both early stress exposure and risk for developing a psychiatric disorder; however, other NR3C1 promoter regions have been underexplored. Exon 1D emerges as a suggestive new target in stress-related disorders epigenetically sensitive to early adversity...
April 9, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29649711/the-interaction-of-bdnf-val66met-ptsd-and-child-abuse-on-psychophysiological-reactivity-and-hpa-axis-function-in-a-sample-of-gulf-war-veterans
#15
Dmitri A Young, Thomas C Neylan, Aoife O'Donovan, Thomas Metzler, Anne Richards, Jessica A Ross, Sabra S Inslicht
INTRODUCTION: While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans. METHODS: 226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively...
April 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29627713/chronic-stress-hair-cortisol-and-depression-a-prospective-and-longitudinal-study-of-medical-internship
#16
Stefanie E Mayer, Nestor L Lopez-Duran, Srijan Sen, James L Abelson
BACKGROUND: Stress plays a causal role in depression onset, perhaps via alteration of hypothalamic-pituitary-adrenal (HPA) axis functioning. HPA axis hyperactivity has been reported in depression, though inconsistently, and the nature of this relationship remains unclear, partly because cortisol measurement over time has been challenging. Development of hair cortisol assessment, a method that captures cortisol over prolonged periods of time, creates new possibilities. In this study, hair cortisol was incorporated into a prospective and longitudinal study of medical internship, stress and symptoms of depression...
March 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29627576/magnolol-abrogates-chronic-mild-stress-induced-depressive-like-behaviors-by-inhibiting-neuroinflammation-and-oxidative-stress-in-the-prefrontal-cortex-of-mice
#17
Jie Cheng, Shuqi Dong, Litao Yi, Di Geng, Qing Liu
Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant-like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the aim of this present study was to determine whether magnolol affected these systems in mice exposed to chronic mild stress (CMS). The ameliorative effect of magnolol on depressive-like symptoms was investigated through behavioral tests, including the classical sucrose preference and forced swimming tests...
April 5, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29615850/interplay-between-the-gut-brain-axis-obesity-and-cognitive-function
#18
REVIEW
Ana Agustí, Maria P García-Pardo, Inmaculada López-Almela, Isabel Campillo, Michael Maes, Marina Romaní-Pérez, Yolanda Sanz
Obesity continues to be one of the major public health problems due to its high prevalence and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but also mood and cognitive disorders. Obese subjects often show deficits in memory, learning and executive functions compared to normal weight subjects. Epidemiological studies also indicate that obesity is associated with a higher risk of developing depression and anxiety, and vice versa . These associations between pathologies that presumably have different etiologies suggest shared pathological mechanisms...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29609112/hair-cortisol-concentration-hcc-as-a-measure-for-prenatal-psychological-distress-a-systematic-review
#19
REVIEW
Paula Mustonen, Linnea Karlsson, Noora M Scheinin, Susanna Kortesluoma, Bárbara Coimbra, Ana João Rodrigues, Hasse Karlsson
Prenatal environment reportedly affects the programming of developmental trajectories in offspring and the modification of risks for later morbidity. Among the increasingly studied prenatal exposures are maternal psychological distress (PD) and altered maternal hypothalamus-pituitary-adrenal (HPA) axis functioning. Both prenatal PD and maternal short-term cortisol concentrations as markers for HPA axis activity have been linked to adverse child outcomes and it has been assumed that maternal PD affects the offspring partially via altered cortisol secretion patterns...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29606180/associations-of-prenatal-depressive-symptoms-with-dna-methylation-of-hpa-axis-related-genes-and-diurnal-cortisol-profiles-in-primary-school-aged-children
#20
Valeska Stonawski, Stefan Frey, Yulia Golub, Nicolas Rohleder, Jennifer Kriebel, Tamme W Goecke, Peter A Fasching, Matthias W Beckmann, Johannes Kornhuber, Oliver Kratz, Gunther H Moll, Hartmut Heinrich, Anna Eichler
Epigenetic DNA modifications in genes related to the hypothalamic-pituitary-adrenal (HPA) axis are discussed as a mechanism underlying the association between prenatal depression and altered child HPA activity. In a longitudinal study, DNA methylation changes related to prenatal depressive symptoms were investigated in 167 children aged 6 to 9 years. At six candidate genes, 126 cytosine-guanine dinucleotides were considered without correcting for multiple testing due to the exploratory nature of the study. Further associations with the basal child HPA activity were examined...
April 2, 2018: Development and Psychopathology
keyword
keyword
4893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"