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https://www.readbyqxmd.com/read/28731983/a-systematic-review-and-meta-analysis-of-the-effort-reward-imbalance-model-of-workplace-stress-and-hpa-axis-measures-of-stress
#1
Pennie Eddy, Eleanor H Wertheim, Matthew W Hale, Bradley J Wright
OBJECTIVE: The association between effort reward imbalance (ERI) and various health outcomes has been well-documented over the past 20 years, but the mechanisms responsible for this association remain unclear. The present meta-analysis assessed the associations of ERI and over-commitment (OC) in the workplace with hypothalamic-pituitary-adrenal (HPA) axis measures. METHODS: Electronic databases were searched with the phrase 'effort*reward*imbalance' which yielded 319 studies leading to 56 full text studies being screened...
July 20, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28730966/nicotinic-cholinergic-system-in-the-hypothalamus-modulates-the-activity-of-the-hypothalamic-neuropeptides-during-the-stress-resp
#2
Burcu Balkan, Sakire Pogun
The hypothalamus harbors high levels of cholinergic neurons and axon terminals. Nicotinic acetylcholine receptors, which play an important role in cholinergic neurotransmission, are expressed abundantly in the hypothalamus. Accumulating evidence reveals a regulatory role for nicotine in diverse functions mediated by the hypothalamus, including the regulation of the stress responses. The nicotinic cholinergic system lies at the intersection of homeostatic and reward pathways and shows sex differences in some of its effects...
July 19, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28729344/exogenous-stress-hormones-alter-energetic-and-nutrient-costs-of-development-and-metamorphosis
#3
Lucas J Kirschman, Marshall D McCue, Justin G Boyles, Robin W Warne
Variation in environmental conditions during larval life stages can shape development during critical windows and have lasting effects on the adult organism. Changes in larval developmental rates in response to environmental conditions, for example, can trade-off with growth to determine body size and condition at metamorphosis, which can affect adult survival and fecundity. However, it is unclear how use of energy and nutrients shape trade-offs across life stage transitions because no studies have quantified these costs of larval development and metamorphosis...
July 20, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28728884/glucocorticoid-programming-of-neuroimmune-function
#4
REVIEW
David J Walker, Karen A Spencer
Throughout life physiological systems strive to maintain homeostasis and these systems are susceptible to exposure to maternal or environmental perturbations, particularly during embryonic development. In some cases, these perturbations may influence genetic and physiological processes that permanently alter the functioning of these physiological systems; a process known as developmental programming. In recent years, the neuroimmune system has garnered attention for its fundamental interactions with key hormonal systems, such as the hypothalamic pituitary adrenal (HPA) axis...
July 17, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28720027/long-term-alteration-of-the-hypothalamic-pituitary-adrenal-axis-in-children-undergoing-cardiac-surgery-in-the-first-6-months-of-life
#5
Monica McGauran, Brigid Jordan, Roseriet Beijers, Irma Janssen, Candice Franich-Ray, Carolina de Weerth, Michael Cheung
Children with congenital heart disease (CHD) have poorer neurodevelopmental and psychological outcomes. The mechanisms underlying this remain unclear. One mechanism could be that the stressful experience of cardiac surgery early in life influences long-term hypothalamic-pituitary-adrenal (HPA) axis regulation. Dysregulation of the HPA axis has been linked to poorer neurocognitive and psychological outcomes in other study populations. This case-control study aims to compare HPA-axis regulation (circadian rhythm and reactivity) using salivary cortisol in 3- to 5-year-olds with CHD who did and did not have cardiac surgery prior to 6 months of age...
July 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28719014/bioavailability-and-tolerability-of-nebulised-dexamethasone-sodium-phosphate-in-adult-horses
#6
A D Haspel, S Giguère, K A Hart, L J Berghaus, J L Davis
BACKGROUND: Nebulisation of the injectable dexamethasone sodium phosphate (DSP) would offer an inexpensive way of delivering a potent corticosteroid directly to the lungs of horses with asthma. However, this approach would be advantageous only if systemic absorption is minimal and if the preservatives present in the formulation do not induce airway inflammation. OBJECTIVE: To investigate the bioavailability of nebulised DSP and to determine whether it induces airway inflammation or hypothalamic-pituitary-adrenal (HPA) axis suppression in healthy adult horses...
July 18, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28718999/resilience-is-decreased-in-irritable-bowel-syndrome-and-associated-with-symptoms-and-cortisol-response
#7
S H Park, B D Naliboff, W Shih, A P Presson, E J Videlock, T Ju, L Kilpatrick, A Gupta, E A Mayer, L Chang
BACKGROUND: Irritable bowel syndrome (IBS) is a stress-sensitive disorder associated with early adverse life events (EALs) and a dysregulated hypothalamic-pituitary-adrenal (HPA) axis. Resilience is the ability to recover and adapt positively to stress but has not been well studied in IBS. The aims of this study are to compare resilience in IBS and healthy controls (HCs) and to assess its relationships with IBS symptom severity, quality of life (QOL), EALs, and HPA axis response. METHODS: Two hundred fifty-six subjects (154 IBS, 102 HCs) completed questionnaires for resilience (Connor-Davidson Resilience Scale [CD-RISC] and Brief Resilience Scale [BRS]), IBS symptoms, IBS-QOL, and EALs...
July 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28715822/long-term-cortisol-concentration-in-scalp-hair-of-asthmatic-children-using-inhaled-corticosteroids-a-case-control-study
#8
Maaike P Smit, Ed H G van Leer, Gerard Noppe, Yolanda B de Rijke, Dieneke Kramer van Driel, Erica L T van den Akker
INTRODUCTION: Inhaled corticosteroids (ICS) can interfere with the hypothalamic-pituitary-adrenal (HPA) axis and may lead to adrenal insufficiency, resulting in a decrease of cortisol production. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure. Data regarding hair cortisol concentration (HCC) in asthmatic children with ICS therapy are scarce. The aim of this study is to compare HCC in asthmatic children under ICS treatment with a healthy control group...
July 14, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28715387/a-modified-trier-social-stress-test-for-vulnerable-mexican-american-adolescents
#9
Megan M Johnson, Julianna Deardorff, Kimberly Parra, Abbey Alkon, Brenda Eskenazi, Elizabeth Shirtcliff
The Trier Social Stress Test (TSST) is a well validated and widely used social stressor that has been shown to induce a 2-4 fold increase in cortisol, the biological output produced by the Hypothalamic-Pituitary-Adrenal (HPA) axis in humans. While studies have explored how modifications to the TSST influence stress responsivity, few studies have created a modified TSST appropriate for vulnerable youth that elicits a significant cortisol stress response. Thus, the current study sought to modify or adjust the TSST in a culturally sensitive way for a vulnerable sample of 14 year-old adolescents...
July 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714388/the-prospective-role-of-micrornas-in-depression
#10
Zhiying Hu, Yuting Jiang, Xue Huo, Yang Yang, Henry Davies, Benson O A Botchway, Marong Fang
Depression is a debilitating disease that is affecting a growing number of patients both physically and mentally. In addition to the mood changes, depression causes cognitive impairment, including learning and memory dysfunction. Although depression studies have been going on for decades, the underlying mechanism still remains unclear. MicroRNAs (miRNAs), a type of small non-coding RNAs, predominantly control the expression of their target mRNAs to exert their functions. Some evidence has revealed the importance of miRNAs in the mechanism of depression though the studies are still in their infancy...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28714126/annual-research-review-early-adversity-the-hypothalamic-pituitary-adrenocortical-axis-and-child-psychopathology
#11
REVIEW
Kalsea J Koss, Megan R Gunnar
BACKGROUND: Research on early adversity, stress biology, and child development has grown exponentially in recent years. FINDINGS: We review the current evidence for the hypothalamic-pituitary-adrenocortical (HPA) axis as a stress-mediating mechanism between various forms of childhood adversity and psychopathology. We begin with a review of the neurobiology of the axis and evidence for relations between early adversity-HPA axis activity and HPA axis activity-psychopathology, as well as discuss the role of regulatory mechanisms and sensitive periods in development...
July 17, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28711723/diurnal-cortisol-rhythms-fatigue-and-psychosocial-factors-in-five-year-survivors-of-ovarian-cancer
#12
Michaela G Cuneo, Andrew Schrepf, George M Slavich, Premal H Thaker, Michael Goodheart, David Bender, Steve W Cole, Anil K Sood, Susan K Lutgendorf
Fatigue is a challenge in ovarian cancer survivorship and greatly impacts quality of life. In other cancer populations, fatigue has been associated with abnormal diurnal cortisol patterns. However, little is known about biological and behavioral factors in 5+-year ovarian cancer survivors and potential mechanisms underlying persistent fatigue have not been investigated in this population. Moreover, relationships between neuroendocrine and psychosocial factors in 5+-year ovarian cancer survivors have not been studied...
June 30, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28710520/psychostimulants-and-forced-swim-stress-interaction-how-activation-of-the-hypothalamic-pituitary-adrenal-axis-and-stress-induced-hyperglycemia-are-affected
#13
Humberto Gagliano, Juan Antonio Ortega-Sanchez, Roser Nadal, Antonio Armario
RATIONALE: We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES: This study aims (i) to characterize the effect of various doses of amphetamine on the physiological response to a predominantly emotional stressor (forced swim) when the drug was given immediately before stress; (ii) to study if an interaction appears when the drug was given 30 min or 7 days before swim; and (iii) to know whether cocaine causes similar effects when given just before stress...
July 14, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28710078/endocrinology-and-the-brain-corticotropin-releasing-hormone-signaling
#14
Carolina Inda, Natalia G Armando, Paula A Dos Santos Claro, Susana Silberstein
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral adaptive responses to stress. This review describes molecular components and cellular mechanisms involved in CRH signaling downstream of its G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, and summarizes recent findings that challenge the classical view of GPCR signaling, and impact on our understanding of CRHRs function...
July 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28709905/royal-jelly-decreases-corticosterone-levels-and-improves-the-brain-antioxidant-system-in-restraint-and-cold-stressed-rats
#15
Renata Roland Teixeira, Adriele Vieira de Souza, Leonardo Gomes Peixoto, Helen Lara Machado, Douglas Carvalho Caixeta, Danielle Diniz Vilela, Nathalia Belele Baptista, Celso Rodrigues Franci, Foued Salmen Espindola
Restraint and cold stress induces the hypothalamic-pituitary-adrenal (HPA) axis to release corticosterone from the adrenal gland, which can worsen the antioxidant defense system in the central nervous system. Here, we investigated the corticosterone levels and the antioxidant defense system in the cerebellum and brain, as well as in its isolated regions, such as cerebral cortex, striatum and hippocampus of stressed rats supplemented with royal jelly (RJ). Wistar rats were supplemented with RJ for 14days and the stress induction started on the 7th day...
July 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28700991/strain-differences-and-effects-of-environmental-manipulation-on-astrocytes-glial-fibrillary-acidic-protein-glucocorticoid-receptor-and-microglia-iba1-immunoreactivity-between-wistar-kyoto-and-wistar-females
#16
Guergana R Mileva, Carinna Moyes, Shaezeen Syed, Catherine Bielajew
BACKGROUND: Depression is often associated with an increase in hypothalamic-pituitary-adrenal (HPA) axis reactivity and immune response. To investigate this relationship, we examined the consequences of environmental manipulation on the neural correlates of the HPA axis and immune response in an animal model of depression, the Wistar-Kyoto (WKY) rat. Additionally, female animals are often overlooked in preclinical research because of the hormone fluctuations inherent in the estrous cycle...
July 13, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28694433/antidepressant-effect-of-taurine-in-chronic-unpredictable-mild-stress-induced-depressive-rats
#17
Gao-Feng Wu, Shuang Ren, Ri-Yi Tang, Chang Xu, Jia-Qi Zhou, Shu-Mei Lin, Ying Feng, Qun-Hui Yang, Jian-Min Hu, Jian-Cheng Yang
Depression, a psychiatric and dysthymic disorder, severely affects the learning, work and life quality. The main pathogenesis of depression is associated with central nervous system (CNS) dysfunction. Taurine has been demonstrated to exert protective effects on the brain development and can improve learning ability and memory. Our study investigated the antidepressant-like effects of taurine pre-treatment by examining the changes in depression-like behavior, hormones, neurotransmitters, inflammatory factors and neurotrophic factors in the hippocampus of a chronic unpredictable mild stress (CUMS)-induced depressive rat model...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693541/is-hpa-axis-reactivity-in-childhood-gender-specific-a-systematic-review
#18
REVIEW
Jonneke J Hollanders, Bibian van der Voorn, Joost Rotteveel, Martijn J J Finken
BACKGROUND: In adults, hypothalamus-pituitary-adrenal (HPA) axis activity shows sexual dimorphism, and this is thought to be a mechanism underlying sex-specific disease incidence. Evidence is scarce on whether these sex differences are also present in childhood. In a meta-analysis, we recently found that basal (non-stimulated) cortisol in saliva and free cortisol in 24-h urine follow sex-specific patterns. We explored whether these findings could be extended with sex differences in HPA axis reactivity...
July 11, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28692696/corticosterone-response-to-gestational-stress-and-postpartum-memory-function-in-mice
#19
Zahra Jafari, Jogender Mehla, Navvab Afrashteh, Bryan E Kolb, Majid H Mohajerani
Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors...
2017: PloS One
https://www.readbyqxmd.com/read/28689880/characterization-of-crf1-receptor-antagonists-with-differential-peripheral-vs-central-actions-in-crf-challenge-in-rats
#20
Maiko Tanaka, Yoshiro Tomimatsu, Katsuya Sakimura, Yoshikazu Ootani, Yuu Sako, Takuto Kojima, Kazuyoshi Aso, Takahiko Yano, Keisuke Hirai
The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxiety behavior were measured after CRF challenge intravenously (i.v.) for the peripheral administration or intracerebroventricularly (i.c.v.) for the central administration. Plasma ACTH concentration was significantly increased by both administration routes of CRF; however, hyperlocomotion and anxiety behavior were induced only by the i...
July 6, 2017: Peptides
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