keyword
MENU ▼
Read by QxMD icon Read
search

HPA axis

keyword
https://www.readbyqxmd.com/read/28646798/social-context-matters-ethnicity-discrimination-and-stress-reactivity
#1
David Busse, Ilona S Yim, Belinda Campos
Exposure to chronic discrimination is associated with increased morbidity and mortality. The study of biobehavioral pathways linking discrimination with health outcomes has mostly focused on the cardiovascular system, with fewer studies addressing the hypothalamus-pituitary-adrenal (HPA) axis. In this study we tested associations between Latino ethnicity, experiences of discrimination, and cortisol responses to an acute laboratory stressor. One hundred fifty eight individuals (92 female, 66 male) between the ages of 18 and 29 years participated in the study...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28643132/integrated-inflammatory-stress-itis-model
#2
Elisabeth O Bangsgaard, Poul G Hjorth, Mette S Olufsen, Jesper Mehlsen, Johnny T Ottesen
During the last decade, there has been an increasing interest in the coupling between the acute inflammatory response and the Hypothalamic-Pituitary-Adrenal (HPA) axis. The inflammatory response is activated acutely by pathogen- or damage-related molecular patterns, whereas the HPA axis maintains a long-term level of the stress hormone cortisol which is also anti-inflammatory. A new integrated model of the interaction between these two subsystems of the inflammatory system is proposed and coined the integrated inflammatory stress (ITIS) model...
June 22, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28641771/fatigue-in-multiple-sclerosis-is-it-related-to-cytokines-and-hypothalamic-pituitary-adrenal-axis
#3
Aylin Akcali, Fatma Zengin, Sefika Nur Aksoy, Orhan Zengin
BACKGROUND: Fatigue is a common symptom of Multiple Sclerosis (MS) that diminishes the quality of life of patients, but its exact mechanism remains poorly understood. There is not a generally adopted scale to determine MS fatigue. Studies that investigated physiopathology of fatigue symptom have shown dysregulation of hypothalamic-pituitaryadrenal (HPA) axis. In the current study, we aimed to compare the results obtained with two separate scales, namely the Fatigue Severity Scale (FSS) and the Neurological Fatigue Index-Multiple Sclerosis (NFI-MS), and assess the relationship between fatigue and serum IL-1β, TNF-α, IL-35, IL-2, IL-10, ACTH, cortisol, α-MSH, β-MSH, γ-MSH and CLIP (Corticotropinlike intermediate lobe peptide) in MS patients categorized as fatigued and non-fatigued on the basis of FSS scores...
July 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28641498/glucocorticoid-receptor-genetic-variants-and-response-to-fluoxetine-in-major-depressive-disorder
#4
Hasti Nouraei, Negar Firouzabadi, Ali Mandegary, Kamiar Zomorrodian, Ehsan Bahramali, Mohammad Reza Hooshangi Shayesteh, Saham Ansari
Hyperactivity of the hypothalamic pituitary adrenocortical (HPA) axis is one of the main clinical findings in depression. The HPA axis is interrelated with glucocorticoid signaling via glucocorticoid receptors (GCRs). Thus, functional genetic variants on GCRs might influence therapeutic outcomes in depression. The aim of the present study was to investigate the association between three functional polymorphisms (rs41423247, rs6195, and rs6189/rs6190) on GCR and response to fluoxetine in a group of depressed patients...
June 23, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28641470/do-psychosocial-predictors-affect-the-following-days-cortisol-awakening-response-expanding-the-temporal-frame-with-which-to-explore-morning-cortisol
#5
Jeffrey Proulx, Daniel Klee, Barry S Oken
Much of the extant cortisol awakening response (CAR) literature posits that CAR is an anticipatory response to perceived demands later that same day. However, expanding and switching the temporal order of cortisol and psychosocial influences may motivate more flexible approaches to understanding the dynamic relationship between mind and body, including cumulative strain on the HPA axis. This study was novel because we used two models to explore the effects of one day's emotion regulation and cortisol levels on cortisol and CAR the following day in 100 mildly stressed adults aged 50 - 81 years old, which contrasts with the more common CAR-anticipatory-response design...
June 22, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28641158/determinants-of-cortisol-during-pregnancy-the-abcd-cohort
#6
Laura S Bleker, Tessa J Roseboom, Tanja G Vrijkotte, Rebecca M Reynolds, Susanne R de Rooij
BACKGROUND: Psychosocial stress during pregnancy has been proposed as a major contributor of glucocorticoid-mediated programming of the fetal hypothalamic-pituitary adrenal (HPA) axis, with later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28639383/longitudinal-associations-between-low-morning-cortisol-in-infancy-and-anger-dysregulation-in-early-childhood-in-a-cps-referred-sample
#7
Allison Frost, Caitlin Jelinek, Kristin Bernard, Teresa Lind, Mary Dozier
Children who experience early adversity are at increased risk for developing psychopathology, and dysfunction of the hypothalamic pituitary adrenal (HPA) axis is a possible mechanism conferring this risk. This study sought to characterize the association between morning cortisol during different developmental periods and deficits in children's emotion regulation, a core feature of many psychological disorders. Morning cortisol was collected at two time points (i.e., during infancy, M = 13.0 months old, and during early childhood, M = 36...
June 21, 2017: Developmental Science
https://www.readbyqxmd.com/read/28636887/temporal-dynamics-of-the-hpa-axis-linked-to-exploratory-behavior-in-a-wild-european-songbird-parus-major
#8
Alexander T Baugh, Sarah C Davidson, Michaela Hau, Kees van Oers
Variation in the reactivity of the endocrine stress axis is thought to underlie aspects of persistent individual differences in behavior (i.e. animal personality). Previous studies, however, have focused largely on estimating baseline or peak levels of glucocorticoids (CORT), often in captive animals. In contrast, the temporal dynamics of the HPA axis-how quickly it turns on and off, for example-may better indicate how an individual copes with stressors. Moreover, these HPA components might be correlated, thereby representing endocrine suites...
June 18, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28635080/neuroadaptations-of-presynaptic-and-postsynaptic-gabab-receptor-function-in-the-paraventricular-nucleus-in-response-to-chronic-unpredictable-stress
#9
Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Li Wang, Therese A Kosten, Xiangjian Zhang, De-Pei Li
BACKGROUND: Chronic stress induces an impaired GABAA (γ-aminobutyric acid type A) receptor-mediated inhibition in the hypothalamic paraventricular nucleus (PVN). It is not clear whether GABAB receptor function is altered in chronic stress. We hypothesize that chronic stress alters GABAB receptor function in PVN corticotrophin-releasing hormone (CRH) neurons to control hypothalamus-pituitary-adrenal (HPA) axis activity. EXPERIMENTAL APPROACH: Whole cell patch-clamp recording was performed on PVN-CRH neurons expressing eGFP driven by CRH promoter in brain slices from unstressed rats and rats that had been subjected to chronic unpredictable mild stress (CUMS)...
June 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28627308/hormonal-and-neuromuscular-responses-to-breastfeeding-a-pilot-study
#10
Madalynn Neu, Zhaoxing Pan, Ashley Haight, Karen Fehringer, Katrina Maluf
OBJECTIVES: Difficult breastfeeding in the first weeks after birth may result in muscle tension in infants and activation of the maternal hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS). Our primary objective was to examine the feasibility of collecting neuroendocrine markers of maternal HPA axis and SNS activation (salivary cortisol and α-amylase [sAA]) and electromyographic (EMG) markers of infant distress during feeding in the first 2 weeks after birth...
July 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28623763/saturated-high-fat-feeding-independent-of-obesity-alters-hypothalamus-pituitary-adrenal-axis-function-but-not-anxiety-like-behaviour
#11
Cecile Hryhorczuk, Léa Décarie-Spain, Sandeep Sharma, Caroline Daneault, Christine Des Rosiers, Thierry Alquier, Stephanie Fulton
Overconsumption of dietary fat can elicit impairments in emotional processes and the response to stress. While excess dietary lipids have been shown to alter hypothalamus-pituitary-adrenal (HPA) axis function and promote anxiety-like behaviour, it is not known if such changes rely on elevated body weight and if these effects are specific to the type of dietary fat. The objective of this study was to investigate the effect of a saturated and a monounsaturated high-fat diet (HFD) on HPA axis function and anxiety-like behaviour in rats...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28623762/cortisol-stress-response-in-post-traumatic-stress-disorder-panic-disorder-and-major-depressive-disorder-patients
#12
Susann Wichmann, Clemens Kirschbaum, Carsten Böhme, Katja Petrowski
BACKGROUND: Previous research has focussed extensively on the distinction of HPA-axis functioning between patient groups and healthy volunteers, with relatively little emphasis on a direct comparison of patient groups. The current study's aim was to analyse differences in the cortisol stress response as a function of primary diagnosis of panic disorder (PD), post-traumatic stress disorder (PTSD), and major depressive disorder (MDD). METHODS: A total of n=30 PD (mean age±SD: 36...
June 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28619017/borderline-personality-disorder-and-childhood-trauma-exploring-the-affected-biological-systems-and-mechanisms
#13
Nadia Cattane, Roberta Rossi, Mariangela Lanfredi, Annamaria Cattaneo
BACKGROUND: According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability...
June 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28618657/antidepressive-effects-of-ginsenoside-rg1-via-regulation-of-hpa-and-hpg-axis
#14
Zheng Mou, Qian Huang, Shi-Feng Chu, Mei-Jin Zhang, Jin-Feng Hu, Nai-Hong Chen, Jun-Tian Zhang
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic-pituitary-gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. OBJECTIVE: This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system...
June 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28618114/subjective-insomnia-symptoms-and-sleep-duration-are-not-related-to-hypothalamic-pituitary-adrenal-axis-activity-in-older-adults
#15
Rian J G Peters van Neijenhof, Erik van Duijn, Julia F Van Den Berg, Margot W M de Waal, Roos C van der Mast, Hannie C Comijs
Insomnia symptoms are highly prevalent in depressed older adults. This study investigates the association between hypothalamic-pituitary-adrenal (HPA) axis activity and symptoms of insomnia, respectively, sleep duration among 294 depressed and 123 non-depressed older adults of the Netherlands Study of Depression in Older people (NESDO) study. Insomnia symptoms were defined as clinically relevant when having a score ≥ 10 points on the Women's Health Initiative Insomnia Rating Scale (WHIIRS). Sleep duration was categorized in short (≤ 6 h per night), normal (7-8 h per night) and long (≥ 9 h per night) duration...
June 15, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28617197/chronic-early-life-stress-induced-by-limited-bedding-and-nesting-lbn-material-in-rodents-critical-considerations-of-methodology-outcomes-and-translational-potential
#16
Claire-Dominique Walker, Kevin G Bath, Marian Joels, Aniko Korosi, Muriel Larauche, Paul J Lucassen, Margaret J Morris, Charlis Raineki, Tania L Roth, Regina M Sullivan, Yvette Taché, Tallie Z Baram
The immediate and long term effects of exposure to early life stress (ELS) have been documented in humans and animal models. Even relatively brief periods of stress during the first 10 days of life in rodents can impact later behavioral regulation and the vulnerability to develop adult pathologies, in particular an impairment of cognitive functions and neurogenesis, but also modified social, emotional and conditioned fear responses. The development of preclinical models of ELS exposure allows the examination of mechanisms and testing of therapeutic approaches that are not possible in humans...
June 15, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28617035/measuring-stress-in-young-children-using-hair-cortisol-the-state-of-the-science
#17
Randi Bates, Pamela Salsberry, Jodi Ford
Extensive literature suggests that adverse experiences in early childhood may deleteriously impact later health. These effects are thought to be related to the impact of persistent or chronic stress on various biological processes, mediated by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and ultimately irregularities in cortisol levels. Ameliorating persistent stress in young children requires accurately measuring the chronicity of physiologic stress, which is difficult in young children because of unreliable self-report and the burden and inaccuracy associated with using invasive acute-stress biomeasures...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28612976/lithium-ameliorates-sleep-deprivation-induced-mania-like-behavior-hypothalamic-pituitary-adrenal-hpa-axis-alterations-oxidative-stress-and-elevations-of-cytokine-concentrations-in-the-brain-and-serum-of-mice
#18
Samira S Valvassori, Wilson R Resende, Gustavo Dal-Pont, Heron Sangaletti-Pereira, Fernanda F Gava, Bruna R Peterle, Roger B Varela, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: The goal of the present study was to investigate the effects of lithium administration on behavior, oxidative stress parameters and cytokine levels in the periphery and brain of mice subjected to an animal model of mania induced by paradoxical sleep deprivation (PSD). METHODS: Male C57 mice were treated with saline or lithium for 7 days. The sleep deprivation protocol started on the 5th day during for the last 36 hours of the treatment period. Immediately after the sleep deprivation protocol, animals locomotor activity was evaluated and serum and brain samples was extracted to evaluation of corticosterone and adrenocorticotropic hormone circulating levels, oxidative stress parameters and citokynes levels...
June 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28608542/hpa-axis-linkage-in-parent-child-dyads-effects-of-parent-sex-autism-spectrum-diagnosis-and-dyadic-relationship-behavior
#19
Darby E Saxbe, Ofer Golan, Sharon Ostfeld-Etzion, Yael Hirschler-Guttenberg, Orna Zagoory-Sharon, Ruth Feldman
Families of preschoolers participated in two dyadic home visits, once with mother (56 dyads) and once with father (59 dyads). Each member of the dyad provided three cortisol samples and participated in several interaction tasks that were behaviorally coded. Approximately half of the children had been diagnosed with autism spectrum disorders (ASD), whereas half were typically developing (TD). In a multilevel model, father's cortisol level at each timepoint predicted child cortisol. Father-child linkage was stronger in dyads that showed less reciprocity, in which fathers showed less sensitivity, and in which children showed less self-regulation and more withdrawal...
June 13, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28607630/antioxidant-treatment-induces-hyperactivation-of-the-hpa-axis-by-upregulating-acth-receptor-in-the-adrenal-and-downregulating-glucocorticoid-receptors-in-the-pituitary
#20
Jessika P Prevatto, Rafael C Torres, Bruno L Diaz, Patrícia M R E Silva, Marco A Martins, Vinicius F Carvalho
Glucocorticoid (GC) production is physiologically regulated through a negative feedback loop mediated by the GC, which appear disrupted in several pathological conditions. The inability to perform negative feedback of the hypothalamus-pituitary-adrenal (HPA) axis in several diseases is associated with an overproduction of reactive oxygen species (ROS); however, nothing is known about the effects of ROS on the functionality of the HPA axis during homeostasis. This study analyzed the putative impact of antioxidants on the HPA axis activity and GC-mediated negative feedback upon the HPA cascade...
2017: Oxidative Medicine and Cellular Longevity
keyword
keyword
4893
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"