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Yang Li, Mingming Zhang, Robert G Dorfman, Yida Pan, Dehua Tang, Lei Xu, Zhenguo Zhao, Qian Zhou, Lixing Zhou, Yuming Wang, Yuyao Yin, Shanshan Shen, Bo Kong, Helmut Friess, Shimin Zhao, Lei Wang, Xiaoping Zou
Metastasis is the most important feature of gastric cancer (GC) and the most widely recognized reason for GC-related deaths. Unfortunately, the underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests the dynamic regulatory role of sirtuin2 (SIRT2), a histone deacetylase (HDAC), in cell migration and invasion. The present study aims to evaluate the biological function of SIRT2 in GC and identify the target of SIRT2 as well as evaluate its therapeutic efficacy. We found that SIRT2 was upregulated in GC tissues compared to adjacent normal tissues, and this was correlated with reduced patient survival...
June 17, 2018: Neoplasia: An International Journal for Oncology Research
Haoran Hu, Yue Tang, Libin Pang, Cunlong Lin, Wenhai Huang, Deping Wang, Weitao Jia
There is an urgent demand for wound healing biomaterials because of the increasing frequency of traffic accidents, industrial contingencies and natural disasters. Borate bioactive glass has potential applications in bone tissue engineering and wound healing; however, its uncontrolled release runs a high risk of rapid degradation and transient biotoxicity. In this study, a novel organic-inorganic dressing of copper-doped borate bioactive glass/poly(lactic-co-glycolic acid) loaded with vitamin E (0-3.0 wt.% vitamin E) was fabricated to evaluate its efficiency for angiogenesis in cells and full-thickness skin wounds healing in rodents...
June 20, 2018: ACS Applied Materials & Interfaces
Mingzhu Tang, Liqun Lu, Zhen Huang, Linxi Chen
No abstract text is available yet for this article.
June 19, 2018: Acta Biochimica et Biophysica Sinica
Jiqiang He, Ding Pan, Panfeng Wu, Juyu Tang
A 37-year-old man complained of a refractory posterior malleolar ulceration on his left ankle. He was diagnosed with Werner syndrome according to the progeroid clinical features and genetic testing. To approach the ulceration, a free flow-through right anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve was harvested. One year later, he was readmitted due to a new ulceration on his right ankle. We harvested the left anterolateral thigh perforator flap with anterolateral thigh cutaneous nerve to reconstruct the defect...
June 2018: Anais Brasileiros de Dermatologia
Mi Ju Son, Ojin Kwon, Sungha Kim, Young-Eun Kim, So Young Jung, Bo-Young Kim, Jeong In Kang, Jun-Hwan Lee, Dong-Hyo Lee
INTRODUCTION: A herbal formula, Galgeun-tang-ga-cheongung-sinyi (GGTCS), is traditionally used for the treatment of rhinosinusitis in East Asian countries. However, there is a dearth of clinical evidence supporting the effects of this medication. Here, we describe the protocol for a randomized controlled study designed to investigate the efficacy and safety of GGTCS for the treatment of chronic rhinosinusitis (CRS). METHODS AND ANALYSIS: To investigate the clinical efficacy and safety of GGTCS for the treatment of CRS, a randomized, double-blind, placebo-controlled, parallel group, clinical trial has been designed...
June 2018: Medicine (Baltimore)
Xue He, Zishuai Li, Xunhui Tang, Lijun Zhang, Li Wang, Yongjun He, Tianbo Jin, Dongya Yuan
Significant changes in body composition are known to occur with aging. The aim of the present study was to provide a normative reference of body composition and to investigate age and sex-related differences in healthy subjects by multifrequency bioelectrical impedance analyzer (BIA).A cross-sectional study was conducted on a sample of 3451 healthy Chinese adults, 1611 males and 1840 females. The volunteers were enrolled in 5 different age bands (18-30, 31-40, 41-50, 51-60, 60+). All subjects were measured for weight and height and submitted to BIA, to determine body composition...
June 2018: Medicine (Baltimore)
Renhua Wu, Nanwei Tong, Xinlei Chen, Shishi Xu, Fang Zhang, Lizhi Tang, Yuwei Zhang
RATIONALE: Pheochromocytomas are rare catecholamine-secreting tumors arising from adrenomedullary chromaffin cells, usually causing hypertension, palpitation and headache. However, pheochromocytoma crisis, on the contrary, might present with hypotension, multiple organ dysfunction or even mimicking other diseases, leaving physician with diagnostic difficulties. In this study, we present a case featured hypotension, shock and multiple organ dysfunction syndrome on admission, which nearly lead us to miss the diagnosis of pheochromocytoma...
June 2018: Medicine (Baltimore)
Tingting Hu, Dalong Sun, Jie Zhang, Ruyi Xue, Harry L A Janssen, Wenqing Tang, Ling Dong
AIM: The polyamine catabolic enzyme, spermine oxidase (SMOX) is up-regulated in chronic inflammatory conditions and linked to increased reactive oxygen species (ROS) and DNA damage in various forms of cancers. The present study aims to explore the expression pattern and biological function of SMOX in hepatocellular carcinoma (HCC). METHODS: We used qRT-PCR, Western blotting and immunohistochemistry to examine SMOX expression in four HCC cell lines and 120 cases of HCC clinical samples, and the clinical significance of SMOX was analyzed...
June 20, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
S Sun, Y M Tian, J M Tang, Q X Zhang, Y L Hu, P F Wang, L Y Xue, L Liu, H Tang
OBJECTIVES: To validate the analysis capability of RapidHIT™ 200 system for four kinds of routine forensic samples and the recyclable capability of template, template DNA and PCR products in the process of twice duplicate detection. METHODS: The buccal swabs underwent the test twice by RapidHIT™ 200 system, and the template DNA and PCR products that arose in the system were also tested for two times. After four kinds of routine forensic samples were detected by RapidHIT™ 200 system, the follow-up tests of the template, template DNA and PCR products that arose in the system were performed...
April 2018: Fa Yi Xue za Zhi
Z W Zhang, Z Y Zheng, R Li, S Y Zhou, W Tang, J P Zhou, B Wang
OBJECTIVES: To analyse 73 medical malpractice cases of pediatrics for discussing the importance of forensic pathology in solving the issues such as medical malpractice of pediatrics. METHODS: From January 2002 to August 2016, 73 medical malpractice cases of pediatrics with age of death between 28 days old and 10 years old were collected from Institute of Judical Expertise of Nanjing Medical University. The relationship between causes of death and related medical institutions was retrospectively analysed...
April 2018: Fa Yi Xue za Zhi
Y N Li, M Li, L Jiang, X H Luan, N Liang, Q N Xu, J S Zhang, M C Tang, Y N Bian, L Q Chen
OBJECTIVES: To evaluate the application of 43-plex SNP typing system in forensic science. METHODS: The typing of 43 SNP loci in 123 unrelated Han individuals from East China was detected by MALDI-TOF-MS. The application value of 43-plex SNP typing system was assessed according to the forensic parameters of population genetics. RESULTS: All the 43 SNP loci of 123 individuals showed no significant departure from Hardy-Weinberg equilibrium ( P >0...
April 2018: Fa Yi Xue za Zhi
Hongyan Xu, Xinping Zhu, Wei Li, Zhoukai Tang, Yanyan Zhao, Xuling Wu
Gonadal cell lines provide valuable tools for studying gametogenesis, sex differentiation, and manipulating germ cells in reproductive biology. Female germline stem cells have been characterized and isolated from ovaries of mammalian species, including mice and human, but there has been very few studies on female germline stem cells in reptiles. Here, we described an ovarian stem cell-like line isolated and cultured from the Chinese soft-shell turtle (Pelodiscus sinensis), designated as PSO1. The cells showed high alkaline phosphatase activity with a normal diploid karyotype...
June 20, 2018: Journal of Cellular Biochemistry
Zhongjian Xie, Yuanyuan Tang, Mao-Qiang Man, Chandrama Shrestha, Daniel D Bikle
p120-catenin (p120) is an important regulator in the function and stability of E-cadherin. However, the role of p120 in the epidermis is unclear. Previous studies have shown that globally knockout of p120 caused increased epidermal proliferation but little changes in epidermal differentiation and permeability. In the present study, we generated a conditional knockout mouse model and examined epidermal proliferation, differentiation and permeability. The results showed that conditional knockout of p120 in the epidermis caused not only increased epidermal proliferation but also decreased epidermal differentiation and increased permeability...
June 19, 2018: Journal of Cellular Physiology
Kaipeng Xie, Bo Xu, Yuqing Zhang, Minjian Chen, Yinwen Ji, Jie Wang, Zhenyao Huang, Kun Zhou, Yankai Xia, Wei Tang
We aimed to explore the effects of Inflammatory cytokines (IL-1β, IFN-γ, TNF-α) on pancreatic β-cells. CCK-8 assay showed that the cell viability decreased after 24 hr treatment of TNF-α, 48 hr of IFN-γ, and 84 hr of IL-1β. EdU assay illustrated that after 24 hr treatment, there were significantly reduced EdU-labeled red fluorescence cells in TNF-α group while not in IFN-γ and IL-1β groups. Flow Cytometry results displayed that TNF-α and IFN-γ groups increased apoptosis while IL-1β group did not...
June 19, 2018: Journal of Cellular Physiology
Fengyuan Wang, Zhicai Zuo, Kejie Chen, Xi Peng, Jing Fang, Hengmin Cui, Gang Shu, Min He, Li Tang
Cecal tonsil is the largest peripheral lymphoid organ of the gut-associated lymphoid tissue executing immune function. To evaluate the protective effect of selenium (Se) on the cecal tonsil of chicken exposed to aflatoxin B1 (AFB1 ), 144 1-day-old healthy Cobb chickens were randomly divided into four groups, and fed with basal diet (control group), 0.6 mg/kg AFB1 (AFB1 group), 0.4 mg/kg Se supplement (+Se group), and 0.6 mg/kg AFB1  + 0.4 mg/kg Se supplement (AFB1  + Se group) for 21 days, respectively...
June 20, 2018: Biological Trace Element Research
Lei Tang, Lu Deng, Harrison X Bai, James Sun, Natalie Neale, Jing Wu, Yinyan Wang, Ken Chang, Raymond Y Huang, Paul J Zhang, Xuejun Li, Bo Xiao, Ya Cao, Yongguang Tao, Li Yang
BACKGROUND: Lower-grade gliomas (LGGs, defined as WHO grades II and III) with 1p19q codeletion have increased chemosensitivity when compared to LGGs without 1p19q codeletion, but the mechanism is currently unknown. METHODS: RNAseq data from 515 LGG patients in the Cancer Genome Atlas (TCGA) were analyzed to compare the effect of expression of the 9 DNA repair genes located on chromosome arms 1p and 19q on progression free survival (PFS) and overall survival (OS) between patients who received chemotherapy and those who did not...
June 19, 2018: Journal of Neuro-oncology
Barbara Pisano Messing, Elizabeth C Ward, Cathy Lazarus, Keri Ryniak, Melissa Kim, Jessica Silinonte, Dorothy Gold, Carol B Thompson, Karen T Pitman, Ray Blanco, Ryan Sobel, Karen Harrer, Karen Ulmer, Geoffrey Neuner, Kruti Patel, Mei Tang, Gregory Lee
Head and neck cancer (HNC) guidelines recommend regular multidisciplinary team (MDT) monitoring and early intervention to optimize dysphagia outcomes; however, many factors affect the ability to achieve these goals. The aims of this study were to explore the barriers/facilitators to establishing and sustaining a MDT HNC care pathway and to examine the dysphagia-related speech-language pathology (SLP) and dietetic components of the pathway. Using the Consolidated Framework for Implementation Research (CFIR), a mixed methods study design was used to evaluate an established MDT HNC pathway...
June 19, 2018: Dysphagia
Yanyu Wu, José M Veleta, Diya Tang, Alex D Price, Cristian E Botez, Dino Villagrán
Herein, we report a crystalline CoTcPP-based [TcPP = the anion of meso-tetra(4-carboxyphenyl)porphyrin] polymeric system, 1, as a hydrogen evolution reaction (HER) electrocatalyst in acidic aqueous media. The material was characterized by powder X-ray diffraction (p-XRD), Fourier transform infrared (FT-IR) spectroscopy, and energy dispersive X-ray (EDX) analysis and its morphology was probed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Polymer 1 shows a surface area of 441...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
X Tang, S Teng, M Petri, C Krettek, C Liu, M Jagodzinski
Objectives: The aims of this study were to determine whether the administration of anti-inflammatory and antifibrotic agents affect the proliferation, viability, and expression of markers involved in the fibrotic development of the fibroblasts obtained from arthrofibrotic tissue in vitro , and to evaluate the effect of the agents on arthrofibrosis prevention in vivo . Methods: Dexamethasone, diclofenac, and decorin, in different concentrations, were employed to treat fibroblasts from arthrofibrotic tissue (AFib)...
March 2018: Bone & Joint Research
Zhongmeng Yang, Yuxing Tang, Qing Zhao, Huading Lu, Guoyong Xu
Objectives: Osteoarthritis (OA), characterized by degradation of articular cartilage, is a leading cause of disability. As the only cell type present in cartilage, chondrocytes play curial roles in the progression of OA. In our study, we aimed to explore the roles of miR-23b in the lipopolysaccharide (LPS)-induced inflammatory injury. Materials and Methods: LPS-induced cell injury of ATDC5 cells was evaluated by the loss of cell viability, enhancement of cell apoptosis, alteration of apoptosis-associated proteins, and release of inflammatory cytokines...
May 2018: Iranian Journal of Basic Medical Sciences
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