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https://www.readbyqxmd.com/read/28719880/a-scheme-to-scientifically-and-accurately-assess-cadmium-pollution-of-river-sediments-through-consideration-of-bioavailability-when-assessing-ecological-risk
#1
Zhixin Song, Wenzhong Tang, Baoqing Shan
Evaluating heavy metal pollution status and ecological risk in river sediments is a complex task, requiring consideration of contaminant pollution levels, as well as effects of biological processes within the river system. There are currently no simple or low-cost approaches to heavy metal assessment in river sediments. Here, we introduce a system of assessment for pollution status of heavy metals in river sediments, using measurements of Cd in the Shaocun River sediments as a case study. This system can be used to identify high-risk zones of the river that should be given more attention...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28719823/supplementation-with-dietary-linseed-oil-during-peri-puberty-stimulates-steroidogenesis-and-testis-development-in-rams
#2
REVIEW
Wanhong Li, Defu Tang, Fadi Li, Huaqin Tian, Xiangpeng Yue, Fei Li, Xiuxiu Weng, Wu Sun, Weimin Wang, Futao Mo
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), such as α-linolenic acid (ALA), eicosapentaenoic acid, and docosahexaenoic acid, are involved in male reproductive function. In this study, we investigated the effects of linseed oil (LO) as a source of ALA on the steroidogenesis and changes of testicular histology in rams. Sixteen 3-month old rams during peri-puberty were randomly assigned into two groups. Eight rams were assigned as the control group, and the other received LO (4% dry matter of total diet) as the LO treatment group...
July 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/28719579/using-primate-neural-stem-cells-cultured-in-self-assembling-peptide-nanofiber-scaffolds-to-repair-injured-spinal-cords-in-rats
#3
J-C Ye, Y Qin, Y-F Wu, P Wang, Y Tang, L Huang, M-J Ma, Y-S Zeng, H-Y Shen
This corrects the article DOI: 10.1038/sc.2016.36.
July 18, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28719279/clinical-characteristics-and-prognosis-of-penicilliosis-among-human-immunodeficiency-virus-infected-patients-in-eastern-china
#4
Jun Chen, Renfang Zhang, Yinzhong Shen, Li Liu, Tangkai Qi, Zhenyan Wang, Wei Song, Yang Tang, Hongzhou Lu
AbstractTalaromyces marneffei infection is increasingly observed in people living with human immunodeficiency virus (HIV) in eastern China, a nonendemic area. This study aimed to draw the clinician's attention to this disease by presenting the clinical characteristics and prognosis of penicilliosis among HIV-infected patients from this region. We retrospectively analyzed HIV-infected patients with culture-proven T. marneffei infection admitted during January 1, 2014-December 31, 2015, at the Shanghai Public Health Clinical Center...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719192/precise-molecular-design-of-high-tc-3d-organic-inorganic-perovskite-ferroelectric-mehdabco-rbi3-mehdabco-n-methyl-1-4-diazabi-cyclo-2-2-2-octane
#5
Wan-Ying Zhang, Yuan-Yuan Tang, Peng-Fei Li, Ping-Ping Shi, Wei-Qiang Liao, Da-Wei Fu, Heng-Yun Ye, Yi Zhang, Ren-Gen Xiong
With the flourishing development of (CH3NH3)PbI3, three-dimensional (3D) organic-inorganic perovskites with unique structure-property flexibility have become a worldwide focus. However, they still face great challenges in effec-tively inducing ferroelectricity. Despite the typical 3D perovskite structure and the ability of dabco to trigger phase transition, unfortunately [H2dabco]RbCl3 (dabco = 1,4-diazabicyclo[2.2.2]octane) adopts a nonpolar crystal structure without ferroelectricity. Within larger RbI3 framework, we assemble N-methyl-dabco gained by reducing the molecular symmetry of dabco into a new 3D organic-inorganic perovskite...
July 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28719152/a-first-in-human-phase-i-multicenter-open-label-dose-escalation-study-of-the-oral-raf-vegfr-2-inhibitor-raf265-in-locally-advanced-or-metastatic-melanoma-independent-from-braf-mutation-status
#6
Benjamin Izar, William Sharfman, F Stephen Hodi, Donald Lawrence, Keith T Flaherty, Ravi Amaravadi, Kevin B Kim, Igor Puzanov, Jeffrey Sosman, Reinhard Dummer, Simone M Goldinger, Lyhping Lam, Shefali Kakar, Zhongwen Tang, Oliver Krieter, David F McDermott, Michael B Atkins
To establish the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), safety profile, and anti-tumor efficacy of RAF265. We conducted a multicenter, open-label, phase-I, dose-escalation trial of RAF265, an orally available RAF kinase/VEGFR-2 inhibitor, in patients with advanced or metastatic melanoma. Pharmacokinetic (PK) analysis, pharmacodynamics (PD) and tumor response assessment were conducted. We evaluated metabolic tumor response by 18[F]-fluorodeoxyglucose-positron-emission tomography (FDG-PET), tissue biomarkers using immunohistochemistry (IHC), and modulators of angiogenesis...
July 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28719139/identification-of-metabolites-in-human-and-rat-urine-after-oral-administration-of-xiao-qing-long-tang-granule-using-ultra-high-performance-liquid-chromatography-combined-with-quadrupole-time-of-flight-mass-spectrometry
#7
Lei Zhou, Qiang Zhang, Wen Qi, Shuai Yan, Jialin Qu, Toshiaki Makino, Dan Yuan
Xiao-Qing-Long-Tang is a traditional Chinese formula used for the treatment of cold syndrome, bronchitis, and nasal allergies for thousands of years. However, the in vivo integrated metabolism of its multiple components and the active chemical constituents of Xiao-Qing-Long-Tang remain unknown. In this study, a method using ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry was established for the detection and identification of the metabolites in human and rat urine after oral administration of Xiao-Qing-Long-Tang...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28718942/the-shift-toward-neo-adjuvant-chemotherapy-and-interval-debulking-surgery-for-management-of-advanced-ovarian-and-related-cancers-in-a-population-based-setting-impact-on-clinical-outcomes
#8
James L Nicklin, Shaun McGrath, Lee Tripcony, Andrea Garrett, Russell Land, Amy Tang, Lewis Perrin, Naven Chetty, Nisha Jagasia, Alex J Crandon, Marcelo Nascimento, Graeme Walker, Karen Sanday, Andreas Obermair
OBJECTIVES: The aim of this study was to determine the proportion of patients with advanced ovarian and related cancers (EOC+RC), treated with neoadjuvant chemotherapy and interval debulking surgery (NACT - IDS), and to determine if there was any relationship with optimal cytoreduction rates and overall survival (OS) in a state-wide gynaecologic oncology service over time. METHODS: A retrospective review was undertaken using a population-based database of patients with stages 3 and 4 EOC+RC treated from 1982 till 2013 at the Queensland Centre for Gynaecological Cancer (QCGC)...
July 18, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28718774/effects-of-microchannel-confinement-on-acoustic-vaporisation-of-ultrasound-phase-change-contrast-agents
#9
Shengtao Lin, Ge Zhang, Chee Hau Leow, Meng-Xing Tang
The sub-micron phase change contrast agent (PCCA) composed of a perfluorocarbon liquid core can be activated into gaseous state and form stable echogenic microbubbles for contrast-enhanced ultrasound imaging. It has shown great promises in imaging microvasculature, tumour microenvironment, and cancer cells. Although PCCAs have been extensively studied for different diagnostic and therapeutic applications, the effect of biologically geometrical confinement on the acoustic vaporisation of PCCAs is still not clear...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28718451/nacl-assisted-one-step-growth-of-mos2-ws2-in-plane-heterostructures
#10
Zhan Wang, Yong Xie, Haolin Wang, Ruixue Wu, Tang Nan, Yongjie Zhan, Jing Sun, Teng Jiang, Ying Zhao, Yimin Lei, Mei Yang, Weidong Wang, Qing Zhu, Xiaohua Ma, Yue Hao
Transition metal dichalcogenides (TMDs) have attracted considerable interest for exploration of next-generation electronics and optoelectronics in recent years. Fabrication of in-plane lateral heterostructures between TMDs has opened up excellent opportunities for engineering two-dimensional materials. The creation of high quality heterostructures with a facile method is highly desirable but it still remains challenging. In this work, we demonstrate a one-step growth method for the construction of high-quality MoS2-WS2 in-plane heterostructures...
July 18, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28718327/fibrin-glue-increases-the-tensile-strength-of-conduit-assisted-primary-digital-nerve-repair
#11
Jessica R Childe, Steven Regal, Patrick Schimoler, Alexander Kharlamov, Mark C Miller, Peter Tang
BACKGROUND: An ideal peripheral nerve repair construct does not currently exist. Our primary goal was to determine whether fibrin glue adds to the tensile strength of conduit-assisted primary digital nerve repairs. Our secondary goal was to evaluate the impact of varying suture number and location on the tensile strength. METHODS: Ninety cadaveric digital nerves were harvested and divided equally into the following repair groups: A (4/4), B (2/2), C (0/2), D (0/1), and E (0/0) with the first number referring to the number of sutures at the coaptation and the second number referring to the number of sutures at each proximal and distal end of the nerve-conduit junction...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28718215/usp18-protects-against-hepatic-steatosis-and-insulin-resistance-via-its-dub-activity
#12
Shimin An, Ling-Ping Zhao, Li-Jun Shen, Siyuan Wang, Kuo Zhang, Yu Qi, Jilin Zheng, Xiao-Jing Zhang, Xue-Yong Zhu, Rong Bao, Ling Yang, Yue-Xin Lu, Zhi-Gang She, Yi-Da Tang
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, impaired insulin sensitivity and chronic low-grade inflammation. However, the pathogenic mechanism of NAFLD is poorly understood, which hinders the exploration of possible treatments. Here, we first report that ubiquitin-specific protease 18 (USP18), a member of the deubiquitinating (DUB) enzyme family, plays regulatory roles in NAFLD progression. The expression of USP18 was down-regulated in the livers of non-alcoholic steatohepatitis (NASH) patients and high-fat diet (HFD) induced or genetically obese mice...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28718167/are-computer-numerical-control-cnc-manufactured-patient-specific-metal-templates-available-for-posterior-thoracic-pedicle-screw-insertion-feasibility-and-accuracy-evaluation
#13
Xiangxue Kong, Lei Tang, Qiang Ye, Wenhua Huang, Jianyi Li
PURPOSE: Accurate and safe posterior thoracic pedicle insertion (PTPI) remains a challenge. Patient-specific drill templates (PDTs) created by rapid prototyping (RP) can assist in posterior thoracic pedicle insertion, but pose biocompatibility risks. The aims of this study were to develop alternative PDTs with computer numerical control (CNC) and assess their feasibility and accuracy in assisting PTPI. METHODS: Preoperative CT images of 31 cadaveric thoracic vertebras were obtained and then the optimal pedicle screw trajectories were planned...
July 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28718027/comprehensive-analysis-of-mercury-pollution-in-the-surface-riverine-sediments-in-the-haihe-basin-china
#14
Wenzhong Tang, Baoqing Shan, Yu Zhao, Xinhui Wang
The Haihe Basin extends over 318,000 km(2) or 3.3% of the total area of China, has a population of over 120 million, and is one of China's most polluted river basins. We investigated the pollution and risks from mercury (Hg) in surface riverine sediments of this basin and found that total Hg concentrations in surface sediments ranged from 0.001 to 1.05 mg/kg and averaged 0.054 mg/kg. Using the modified European Community Bureau of Reference standard method, we found that the exchangeable/acid-soluble, reducible, oxidizable, and residual fractions of Hg accounted for 9...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28717923/mirna-200a-induce-cell-apoptosis-in-renal-cell-carcinoma-by-directly-targeting-sirt1
#15
Hao Fu, Wenke Song, Xuancai Chen, Tao Guo, Bin Duan, Xinxi Wang, Yachun Tang, Liang Huang, Chi Zhang
Accumulating evidence indicates that microRNAs are implicated in tumor initiation and progression through negatively regulating oncogenes or tumor suppressor genes. In the present study, we report that the expression of miR-200a was significantly lower in renal cell carcinoma (RCC) specimens and RCC cell lines. Restoration of miR-200a suppressed cell growth, arrested cell cycle progression, and promoted cell apoptosis in RCC cell lines. We next used qRT-PCR array technology to identify Sirtuin 1 (SIRT1) as one of the downregulated proteins during miR-200a overexpression in 786-O cells...
July 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28717731/not-all-body-surface-area-formulas-are-the-same-but-does-it-matter
#16
Wasek Faisal, Hoi-Mun Tang, Susan Tiley, Craig Kukard
No abstract text is available yet for this article.
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717580/photoacoustic-ultrasound-dual-imaging-of-human-thyroid-cancers-an-initial-clinical-study
#17
Meng Yang, Lingyi Zhao, Xujin He, Na Su, ChenYang Zhao, Hewen Tang, Tao Hong, Wenbo Li, Fang Yang, Lin Lin, Bing Zhang, Rui Zhang, Yuxin Jiang, Changhui Li
We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on a high-end clinical ultrasound machine. Both healthy and cancerous thyroids were imaged non-invasively, and we compared the photoacoustic imaging with color Doppler ultrasound. The results of photoacoustic thyroid imaging could reveal many blood vessels that were not sensitive for Doppler ultrasound. Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound thyroid examination, which has a great potential for clinical diagnosis...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717216/random-mutagenesis-analysis-and-identification-of-a-novel-c2h2-type-transcription-factor-from-the-nematode-trapping-fungus-arthrobotrys-oligospora
#18
Dewei Jiang, Jing Zhou, Guizhen Bai, Xinjing Xing, Liyan Tang, Xuewei Yang, Juan Li, Ke-Qin Zhang, Jinkui Yang
Arthrobotrys oligospora is a typical nematode-trapping fungus. In this study, 37 transformants of A. oligospora were obtained by REMI (restriction enzyme mediated integration) method and phenotypic properties of nine transformants were analyzed. The nine transformants showed differences in growth, conidiation, trap formation, stress tolerance, and/or pathogenicity among each other and with those of the parental wild-type strain (WT). The insertional sites of the hph cassette were identified in transformants X5 and X13...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717062/the-effect-of-dhea-on-apoptosis-and-cohesin-levels-in-oocytes-in-aged-mice
#19
Nan Chu, Yuyan Gui, Xuemin Qiu, Na Zhang, Lisha Li, Dajin Li, Wei Tang, Hans-Jürgen Gober, Bin Zhang, Ling Wang
Female fertility declines with age as the number of ovarian follicles decreases and aneuploidy increases. Degradation of the cohesin complex might be responsible for age-related aneuploidy. Dehydroepiandrosterone (DHEA) can improve the ovarian reserve and reduce the rate of aneuploidy, but the relationship between DHEA and cohesin levels in oocytes is still unknown. The aim of the current study was to evaluate the effect of the supplement DHEA on ovarian function, including the number of follicles and cohesin levels in oocytes...
July 17, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28717041/activation-of-sting-in-hepatocytes-suppresses-the-replication-of-hepatitis-b-virus
#20
Fang Guo, Liudi Tang, Sainan Shu, Mohit Sehgal, Muhammad Sheraz, Bowei Liu, Qiong Zhao, Junjun Cheng, Xuesen Zhao, Tianlun Zhou, Jinhong Chang, Ju-Tao Guo
Induction of interferon and proinflammatory cytokines is a hallmark of the infection of many different viruses. However, hepatitis B virus (HBV) does not elicit a detectable cytokine response in infected hepatocytes. In order to investigate the molecular mechanism underlying the innate immune evasion, a functional cGAS-STING pathway was reconstituted in a human hepatoma cell line supporting tetracycline-inducible HBV replication. It was demonstrated that induction of HBV replication neither activated nor inhibited this cytosolic DNA sensing pathway...
July 17, 2017: Antimicrobial Agents and Chemotherapy
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