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Erico Masala, Ana Valencia-Martinez, Serena Pillozzi, Tommaso Rondelli, Alice Brogi, Alessandro Sanna, Antonella Gozzini, Annarosa Arcangeli, Persio Dello Sbarba, Valeria Santini
Myelodysplastic Syndromes (MDS) are clonal neoplasms where stem/progenitor cells endowed with self-renewal and capable of perpetuating the disease have been demonstrated. It is known that oxygen tension plays a key role in driving normal hematopoiesis and that hematopoietic stem cells are maintained in hypoxic areas of the bone marrow (BM). Hypoxia could also regulate leukemic/dysplastic hematopoiesis. We evaluated the stem cell potential of MDS cells derived from the BM of 39 MDS patients and selected under severe hypoxia...
February 13, 2018: Oncotarget
Gulisa Turashvili, Monica Gonzalez-Loperena, Edi Brogi, Maura Dickler, Larry Norton, Monica Morrow, Hannah Y Wen
BACKGROUND: Given the limited data, systemic treatment of male breast cancer has been extrapolated from female patients. The 21-gene recurrence score (RS) assay estimates the risk of distant recurrence and chemotherapy benefit in early-stage, ER+/HER2- female breast cancer. We assessed the association between RS and type of treatment in male breast cancer. METHODS: We identified male patients with ER+/HER2- breast cancer and available RS results treated at our institution in 2006-2016...
March 8, 2018: Annals of Surgical Oncology
Simone Brogi, Margherita Brindisi, Stefania Butini, Giridhar Uttam Kshirsagar, Samuele Maramai, Giulia Chemi, Sandra Gemma, Giuseppe Campiani, Ettore Novellino, Paolo Fiorenzani, Jessica Pinassi, Anna Maria Aloisi, Mikko Gynther, Raminta Venskutonyte, Liwei Han, Karla Frydenvang, Jette Sandholm Kastrup, Darryl S Pickering
Starting from 1-4 and 7 structural templates, analogues based on bioisosteric replacements (5a-c vs 1, 2 and 6 vs 7) were synthesized for completing the SAR analysis. Interesting binding properties at GluA2, GluK1 and GluK3 receptors were discovered. The requirements for GluK3 interaction were elucidated determining the X-ray structures of the GluK3-LBD with 2 and 5c and by computational studies. Antinociceptive potential was demonstrated for GluK1 partial agonist 3 and antagonist 7 (2 mg/kg ip).
February 16, 2018: Journal of Medicinal Chemistry
Luigi Vetrugno, Etrusca Brogi, Federico Barbariol, Francesco Forfori, Elena Bignami
No abstract text is available yet for this article.
March 2018: Anesthesiology
Simona Retelletti Brogi, Sun-Yong Ha, Kwanwoo Kim, Morgane Derrien, Yun Kyung Lee, Jin Hur
Sea ice contains a large amount of dissolved organic matter (DOM), which can be released into the ocean once it melts. In this study, Arctic sea ice DOM was characterized for its optical (fluorescence) properties as well as the molecular sizes and composition via size exclusion chromatography and Fourier transformation ion cyclotron resonance mass spectrometry (FT-ICR MS). Ice cores were collected along with the underlying seawater samples in Cambridge Bay, an Arctic area experiencing seasonal ice formation...
February 1, 2018: Science of the Total Environment
Hannah Y Wen, Edi Brogi
Lobular carcinoma in situ (LCIS) is a risk factor and a nonobligate precursor of breast carcinoma. The relative risk of invasive carcinoma after classic LCIS diagnosis is approximately 9 to 10 times that of the general population. Classic LCIS diagnosed on core biopsy with concordant imaging and pathologic findings does not mandate surgical excision, and margin status is not reported. The identification of variant LCIS in a needle core biopsy specimen mandates surgical excision, regardless of radiologic-pathologic concordance...
March 2018: Surgical Pathology Clinics
Marco Paolino, Margherita Brindisi, Alessandra Vallone, Stefania Butini, Giusepp Campiani, Chiara Nannicini, Germano Giuliani, Maurizio Anzini, Stefania Lamponi, Gianluca Giorgi, Diego Sbardella, Davide M Ferraris, Stefano Marini, Massimo Coletta, Ivana Palucci, Mariachiara Minerva, Giovanni Delogu, Ilaria Pepponi, Delia Goletti, Andrea Cappelli, Sandra Gemma, Simone Brogi
The enzyme Zmp1 is a zinc-peptidase having a critical role in M. tuberculosis pathogenicity. Here we describe the identification of a small set of Zmp1 inhibitors based on a novel 8-hydroxyquinoline-2-hydroxamate scaffold. Among the synthesized compounds, 1c was the most potent Zmp1 inhibitor known to date, and its binding mode was analysed both through kinetic studies and molecular modelling, identifying critical interactions of 1c with the zinc-ion and residues in the active site. Effect of 1c on intracellular Mycobacterium survival was assayed in J774 murine macrophages infected with M...
January 15, 2018: ChemMedChem
Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen
BACKGROUND: The 21-gene recurrence score (RS) assay determines the benefit of adding chemotherapy to endocrine therapy for patients with early stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. The RS risk groups predict the likelihood of distant recurrence and have recently been associated with an increased risk of locoregional recurrence (LRR). This study analyzed clinicopathologic features of patients with low RS and LRR. METHODS: In our institutional database, we identified 1396 consecutive female patients with lymph node negative, ER+/HER2- invasive breast carcinoma and low RS (<18) results, treated at our center from 2008 to 2013...
January 6, 2018: BMC Cancer
E Brogi, L Gargani, E Bignami, F Barbariol, A Marra, F Forfori, L Vetrugno
Pleural effusion (PLEFF), mostly caused by volume overload, congestive heart failure, and pleuropulmonary infection, is a common condition in critical care patients. Thoracic ultrasound (TUS) helps clinicians not only to visualize pleural effusion, but also to distinguish between the different types. Furthermore, TUS is essential during thoracentesis and chest tube drainage as it increases safety and decreases life-threatening complications. It is crucial not only during needle or tube drainage insertion, but also to monitor the volume of the drained PLEFF...
December 28, 2017: Critical Care: the Official Journal of the Critical Care Forum
Gulisa Turashvili, Edi Brogi
Breast cancer is a heterogeneous disease and differs greatly among different patients (intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity). Clinical and morphologic intertumor heterogeneity is reflected by staging systems and histopathologic classification of breast cancer. Heterogeneity in the expression of established prognostic and predictive biomarkers, hormone receptors, and human epidermal growth factor receptor 2 oncoprotein is the basis for targeted treatment. Molecular classifications are indicators of genetic tumor heterogeneity, which is probed with multigene assays and can lead to improved stratification into low- and high-risk groups for personalized therapy...
2017: Frontiers in Medicine
O Adriani, Y Akaike, K Asano, Y Asaoka, M G Bagliesi, G Bigongiari, W R Binns, S Bonechi, M Bongi, P Brogi, J H Buckley, N Cannady, G Castellini, C Checchia, M L Cherry, G Collazuol, V Di Felice, K Ebisawa, H Fuke, T G Guzik, T Hams, M Hareyama, N Hasebe, K Hibino, M Ichimura, K Ioka, W Ishizaki, M H Israel, A Javaid, K Kasahara, J Kataoka, R Kataoka, Y Katayose, C Kato, N Kawanaka, Y Kawakubo, H S Krawczynski, J F Krizmanic, S Kuramata, T Lomtadze, P Maestro, P S Marrocchesi, A M Messineo, J W Mitchell, S Miyake, K Mizutani, A A Moiseev, K Mori, M Mori, N Mori, H M Motz, K Munakata, H Murakami, S Nakahira, J Nishimura, G A de Nolfo, S Okuno, J F Ormes, S Ozawa, L Pacini, F Palma, P Papini, A V Penacchioni, B F Rauch, S B Ricciarini, K Sakai, T Sakamoto, M Sasaki, Y Shimizu, A Shiomi, R Sparvoli, P Spillantini, F Stolzi, I Takahashi, M Takayanagi, M Takita, T Tamura, N Tateyama, T Terasawa, H Tomida, S Torii, Y Tsunesada, Y Uchihori, S Ueno, E Vannuccini, J P Wefel, K Yamaoka, S Yanagita, A Yoshida, K Yoshida, T Yuda
First results of a cosmic-ray electron and positron spectrum from 10 GeV to 3 TeV is presented based upon observations with the CALET instrument on the International Space Station starting in October, 2015. Nearly a half million electron and positron events are included in the analysis. CALET is an all-calorimetric instrument with total vertical thickness of 30 X_{0} and a fine imaging capability designed to achieve a large proton rejection and excellent energy resolution well into the TeV energy region. The observed energy spectrum over 30 GeV can be fit with a single power law with a spectral index of -3...
November 3, 2017: Physical Review Letters
Simone Brogi, Samuele Maramai, Margherita Brindisi, Giulia Chemi, Valentina Porcari, Claudio Corallo, Luigi Gennari, Ettore Novellino, Anna Ramunno, Stefania Butini, Giuseppe Campiani, Sandra Gemma
A computational analysis of the X-ray structure of the low-density lipoprotein receptor-related protein 6 (LRP6) with the Dickkopf-1 (DKK1) C-terminal fragment has allowed us to rationally design a small set of decapeptides. These compounds behave as agonists of the canonical Wnt pathway in the micromolar range when tested on a dual luciferase Wnt functional assay in glioblastoma cells. Two of the oligopeptides showed a lack of cytotoxicity in human primary osteoblasts isolated from sponge bone tissue (femoral heads or knees of elderly patients)...
December 19, 2017: ChemMedChem
F Brogi, O Malaspinas, B Chopard, C Bonadonna
The lattice Boltzmann method (LBM) is emerging as a powerful engineering tool for aeroacoustic computations. However, the LBM has been shown to present accuracy and stability issues in the medium-low Mach number range, which is of interest for aeroacoustic applications. Several solutions have been proposed but are often too computationally expensive, do not retain the simplicity and the advantages typical of the LBM, or are not described well enough to be usable by the community due to proprietary software policies...
October 2017: Journal of the Acoustical Society of America
Fresia Pareja, Felipe C Geyer, Rahul Kumar, Pier Selenica, Salvatore Piscuoglio, Charlotte K Y Ng, Kathleen A Burke, Marcia Edelweiss, Melissa P Murray, Edi Brogi, Britta Weigelt, Jorge S Reis-Filho
Breast fibroepithelial lesions (fibroadenomas and phyllodes tumors) are underpinned by recurrent MED12 exon 2 mutations, which are more common in fibroadenomas and benign phyllodes tumors. TERT promoter hotspot mutations have been documented in phyllodes tumors, and found to be more frequent in borderline and malignant lesions. Several lines of evidence suggest that a subset of phyllodes tumors might arise from fibroadenomas. Here we sought to investigate the genetic differences between phyllodes tumors with fibroadenoma-like areas vs...
2017: NPJ Breast Cancer
Diego Franciotta, Matteo Gastaldi, Luana Benedetti, Martina Garnero, Tiziana Biagioli, Marco Brogi, Gianna Costa, Elisabetta Fadda, Francesca Andreetta, Ornella Simoncini, Claudia Giannotta, Elena Bazzigaluppi, Raffaella Fazio, Roberta Bedin, Diana Ferraro, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Valentina De Riva, Elisabetta Zardini, Andrea Cortese, Eduardo Nobile-Orazio
This document presents the guidelines for anti-myelin-associated glycoprotein (MAG) antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of sponsoring Italian Association of Neuroimmunology (AINI) congresses. The main clinical information on anti-MAG antibody polyneuropathy, indications and limits of anti-MAG antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
Marco Zoccarato, Matteo Gastaldi, Luigi Zuliani, Tiziana Biagioli, Marco Brogi, Gaetano Bernardi, Elena Corsini, Elena Bazzigaluppi, Raffaella Fazio, Claudia Giannotta, Eduardo Nobile-Orazio, Gianna Costa, Raffaele Iorio, Amelia Evoli, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Valentina De Riva, Elisabetta Zardini, Diego Franciotta, Bruno Giometto
This document presents the guidelines for onconeural antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on paraneoplastic neurological syndromes, indications and limits of onconeural antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
Etrusca Brogi, Elena Bignami, Luigi Vetrugno, Francesco Forfori
No abstract text is available yet for this article.
November 2017: Critical Care Medicine
David B Page, Hannah Wen, Edi Brogi, Dana Dure, Dara Ross, Kateri J Spinelli, Sujata Patil, Larry Norton, Clifford Hudis, Heather L McArthur
PURPOSE: HER2 copy number by fluorescence in situ hybridization (FISH) is typically reported relative to the centromere enumeration probe 17 (CEP17). HER2/CEP17 ratio could be impacted by alterations in the number of chromosome 17 copies. Monosomy of chromosome 17 (m17) is found in ~ 1900 cases of early-stage HER2-positive breast cancer annually in the United States; however, the efficacy of HER2-directed trastuzumab therapy in these patients is not well characterized. Here, we retrospectively identified HER2-amplified, stage I-III breast cancers with m17 and characterized the impact of trastuzumab treatment...
January 2018: Breast Cancer Research and Treatment
Etrusca Brogi, Elena Bignami, Anna Sidoti, Mohammed Shawar, Luna Gargani, Luigi Vetrugno, Giovanni Volpicelli, Francesco Forfori
BACKGROUND: Lung ultrasound can be used as an alternative to chest radiography (CXR) for the diagnosis and follow-up of various lung diseases in the intensive care unit (ICU). Our aim was to evaluate the influence that introducing a routine daily use of lung ultrasound in critically ill patients may have on the number of CXRs and as a consequence, on medical costs and radiation exposure. METHODS: Data were collected by conducting a retrospective evaluation of the medical records of adult patients who needed thoracic imaging and were admitted to our academic polyvalent ICU...
September 13, 2017: Cardiovascular Ultrasound
Gulisa Turashvili, Joanne F Chou, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis, Hannah Y Wen
BACKGROUND/PURPOSE: The 21-gene recurrence score (RS) assay evaluates the likelihood of distant recurrence and benefit of chemotherapy in lymph node-negative, estrogen receptor (ER)-positive, HER2-negative breast cancer patients. The RS categories are associated with the risk of locoregional recurrence (LRR) in some, but not all studies. METHODS: We reviewed the institutional database to identify consecutive female patients with node-negative, ER+/HER2- breast carcinoma tested for the 21-gene RS assay and treated at our center from 2008 to 2013...
November 2017: Breast Cancer Research and Treatment
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