Thomas G P Grünewald, Sophie Postel-Vinay, Robert T Nakayama, Noah E Berlow, Andrea Bolzicco, Vincenzo Cerullo, Josephine K Dermawan, Anna Maria Frezza, Antoine Italiano, Jia Xiang Jin, François Le Loarer, Javier Martín-Broto, Andrew Pecora, Antonio Perez-Martinez, Yuen Bun Tam, Franck Tirode, Annalisa Trama, Sandro Pasquali, Mariagrazia Vescia, Lukas Wortmann, Michael Wortmann, Akihiko Yoshida, Kim Webb, Paul H Huang, Charles Keller, Cristina R Antonescu
Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal outcome in ~50% of cases despite aggressive multimodal therapies combining surgery, chemotherapy, and irradiation. EpS is traditionally classified in a more common, less aggressive distal (classic) type, and a rarer aggressive proximal type. Both subtypes are characterized by a loss of nuclear INI1 expression, most often following homozygous deletion of its encoding gene SMARCB1 - a core subunit of the SWI/SNF chromatin remodeling complex...
November 2, 2023: Clinical Cancer Research