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Gregory Vurture, Benoit Peyronnet, Andrew Feigin, Milton C Biagioni, Rebecca Gilbert, Nirit Rosenblum, Steven Frucht, Alessandro Di Rocco, Victor W Nitti, Benjamin M Brucker
OBJECTIVE: To assess the safety and efficacy of intradetrusor onabotulinum toxin A injections for the treatment of overactive bladder (OAB) in patients with Parkinson's disease (PD). METHODS: All PD patients who underwent intradetrusor injections of onabotulinum toxin A (BoNT-A) for storage symptoms between 2010 and 2017 were included in a retrospective study. A 100 U dose of BoNT-A (Botox®, Allergan Irvine, CA) was used for the first injection in all patients...
May 16, 2018: Neurourology and Urodynamics
Michael E Seifert, Megan V Yanik, Daniel I Feig, Vera Hauptfeld-Dolejsek, Elizabeth C Mroczek-Musulman, David R Kelly, Frida Rosenblum, Roslyn B Mannon
The implementation of surveillance biopsies in pediatric kidney transplantation remains controversial. Surveillance biopsies detect subclinical injury prior to clinical dysfunction, which could allow for early interventions that prolong allograft survival. We conducted a single-center retrospective cohort study of 120 consecutive pediatric kidney recipients, of whom 103 had surveillance biopsies ≤ 6 months post-transplant. We tested the hypothesis that subclinical inflammation (borderline or T cell-mediated rejection without clinical dysfunction) is associated with a 5-year composite endpoint of acute rejection and allograft failure...
May 15, 2018: American Journal of Transplantation
Jasmine M DeJesus, Susan A Gelman, Gail B Viechnicki, Danielle P Appugliese, Alison L Miller, Katherine L Rosenblum, Julie C Lumeng
Though parental modeling is thought to play a critical role in promoting children's healthy eating, little research has examined maternal food intake and maternal food talk as independent predictors of children's food intake. The present study examines maternal food talk during a structured eating protocol, in which mothers and their children had the opportunity to eat a series of familiar and unfamiliar vegetables and desserts. Several aspects of maternal talk during the protocol were coded, including overall food talk, directives, pronoun use, and questions...
May 11, 2018: Appetite
Joshua Rosenblum, Farshad Anvari, Bahaaldin Alsoufi
The Damus-Kaye-Stansel (DKS) anastomosis was originally described for the treatment of transposition of the great arteries but it is now used mainly for the treatment of single ventricle anomalies in patients who are at risk of developing systemic ventricular outflow tract obstruction (SVOTO). In most instances, DKS is performed as a concomitant procedure at time of bidirectional cavopulmonary connection in these patients. This tutorial we demonstrate our modified double-barrel approach, along with anterior patch augmentation of the distal ascending aorta...
February 13, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
Allison Q Byrne, Thomas J Poorten, Jamie Voyles, Craig K R Willis, Erica Bree Rosenblum
Infection experiments are critical for understanding wildlife disease dynamics. Although infection experiments are typically designed to reduce complexity, disease outcomes still result from complex interactions between host, pathogen, and environmental factors. Cryptic variation across factors can lead to decreased repeatability of infection experiments within and between research groups and hinder research progress. Furthermore, studies with unexpected results are often relegated to the "file drawer" and potential insights gained from these experimental outcomes are lost...
2018: PloS One
Sonia Gaur, Stephanie Harmon, Lauren Rosenblum, Matthew D Greer, Sherif Mehralivand, Mehmet Coskun, Maria J Merino, Bradford J Wood, Joanna H Shih, Peter A Pinto, Peter L Choyke, Baris Turkbey
OBJECTIVE: The purposes of this study were to assess correlation of apparent diffusion coefficient (ADC) and normalized ADC (ratio of tumor to nontumor tissue) with the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) and updated International Society of Urological Pathology (ISUP) categories and to determine how to optimally use ADC metrics for objective assistance in categorizing lesions within PI-RADSv2 guidelines. MATERIALS AND METHODS: In this retrospective study, 100 patients (median age, 62 years; range, 44-75 years; prostate-specific antigen level, 7...
May 7, 2018: AJR. American Journal of Roentgenology
Carmen Fernandez, Jasmine M DeJesus, Alison L Miller, Danielle P Appugliese, Katherine L Rosenblum, Julie C Lumeng, Megan H Pesch
Selective eating in children is commonly measured by parental report questionnaires, yet it is unknown if parents accurately estimate their child's selective eating behavior. The objectives of this study were to test the validity and stability of two measures of selective eating using observed child behavior. Low-income mother-child dyads participated in a videotaped laboratory eating protocol at two time points (baseline: mean child age = 5.9 years; follow-up: mean child age = 8.6 years), during which they were presented with a familiar and an unfamiliar vegetable...
May 2, 2018: Appetite
Lokesh A Kalekar, Michael D Rosenblum
IL-25 from keratinocytes mediates skin inflammation in psoriasis.
May 4, 2018: Science Immunology
Mireille Bitar, Shabbar F Danish, Marc K Rosenblum
Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described variant of low-grade neuroepithelial tumors that exhibits infiltrative growth, histopathological variability with frequently prominent oligodendroglioma-like components, intense labeling for CD34, absence of 1P/19Q codeletion, a distinct DNA methylation signature and genetic alterations involving MAP kinase pathway constituents of either the B-Raf proto-oncogene BRAF or fibroblast growth factor receptors 2 or 3 (FGFR2 and FGFR3)...
April 27, 2018: Clinical Neuropathology
Tianchen Qian, Elizabeth Colantuoni, Aaron Fisher, Michael Rosenblum
Adaptive enrichment designs involve rules for restricting enrollment to a subset of the population during the course of an ongoing trial. This can be used to target those who benefit from the experimental treatment. Trial characteristics such as the accrual rate and the prognostic value of baseline variables are typically unknown when a trial is being planned; these values are typically assumed based on information available before the trial starts. Because of the added complexity in adaptive enrichment designs compared to standard designs, it may be of special concern how sensitive the trial performance is to deviations from assumptions...
December 2017: Contemporary Clinical Trials Communications
Ellen W McGinnis, Ryan S McGinnis, Jessica Hruschak, Emily Bilek, Ka Ip, Diana Morlen, Jamie Lawler, Nestor L Lopez-Duran, Kate Fitzgerald, Katherine L Rosenblum, Maria Muzik
There is a significant need to develop objective measures for identifying children under the age of 8 who have anxiety and depression. If left untreated, early internalizing symptoms can lead to adolescent and adult internalizing disorders as well as comorbidity which can yield significant health problems later in life including increased risk for suicide. To this end, we propose the use of an instrumented fear induction task for identifying children with internalizing disorders, and demonstrate its efficacy in a sample of 63 children between the ages of 3 and 7...
2018: PloS One
Sara Rosenblum
OBJECTIVE: To describe handwriting and executive control features and their inter-relationships among children with developmental dysgraphia, in comparison to controls. METHOD: Participants included 64 children, aged 10-12 years, 32 with dysgraphia based on the Handwriting Proficiency Screening Questionnaire (HPSQ) and 32 matched controls. Children copied a paragraph onto paper affixed to a digitizer that supplied handwriting process objective measures (Computerized Penmanship Evaluation Tool (ComPET)...
2018: PloS One
Kaitlin A Quinn, Mark A Ahlman, Ashkan A Malayeri, Jamie Marko, Ali Cahid Civelek, Joel S Rosenblum, Armin A Bagheri, Peter A Merkel, Elaine Novakovich, Peter C Grayson
OBJECTIVES: To assess agreement between interpretation of magnetic resonance angiography (MRA) and 18 F-fluorodeoxyglucose positron emission tomography (PET) for disease extent and disease activity in large-vessel vasculitis (LVV) and determine associations between imaging and clinical assessments. METHODS: Patients with giant cell arteritis (GCA), Takayasu's arteritis (TAK) and comparators were recruited into a prospective, observational cohort. Imaging and clinical assessments were performed concurrently, blinded to each other...
April 17, 2018: Annals of the Rheumatic Diseases
Cagdas Topcu, Matthias Fruehwirth, Maximilian Moser, Michael Rosenblum, Arkady S Pikovsky
Different measures of heart rate variability and particularly of respiratory sinus arrhythmia are widely used in research and clinical
 applications. Inspired by the ideas from the theory of coupled oscillators, we use simultaneous measurements of respiratory and cardiac activity to perform a nonlinear disentanglement of the heart rate variability into the respiratory-related component and the rest. 
 We suggest to exploit the technique as a universal preprocessing tool, both for the analysis of respiratory influence on the heart rate 
 as well as in cases when effects of other factors on the heart rate variability are in focus...
April 17, 2018: Physiological Measurement
Daniel Rosenblum, Nitin Joshi, Wei Tao, Jeffrey M Karp, Dan Peer
Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none of the actively targeted NCs have advanced past clinical trials. Herein, we review the principles behind targeted delivery approaches to determine potential reasons for their limited clinical translation and success. We propose criteria and considerations that must be taken into account for the development of novel actively targeted NCs...
April 12, 2018: Nature Communications
Hannah Rosenblum, Adam Castano, Julissa Alvarez, Jeff Goldsmith, Stephen Helmke, Mathew S Maurer
BACKGROUND: TTR (transthyretin) cardiac amyloidosis is caused by dissociation of TTR into monomers, which misassemble into amyloid fibrils. TTR stabilizers act at the dimer-dimer interface to prevent dissociation. We investigated differences in survival among patients with TTR cardiac amyloidosis on stabilizer medications compared with those not on stabilizers. METHODS AND RESULTS: A retrospective study of patients with TTR cardiac amyloidosis presenting to a single center was conducted...
April 2018: Circulation. Heart Failure
Tamra Keeney, Mary Slavin, Pamela Kisala, Pengsheng Ni, Allen W Heinemann, Susan Charlifue, Denise C Fyffe, Ralph J Marino, Leslie R Morse, Lynn A Worobey, Denise Tate, David Rosenblum, Ross Zafonte, David Tulsky, Alan M Jette
OBJECTIVE: To examine the ability of the Spinal Cord Injury Functional Index Assistive Technology (SCI-FI/AT) measure to detect change in persons with SCI. DESIGN: Multi-site, longitudinal (12-month follow-up). SETTING: 9 SCI Model Systems programs. PARTICIPANTS: 165 adults with SCI enrolled in the SCI Model Systems database. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: SCI-FI/AT CAT (Basic Mobility, Self-Care, Fine Motor Function, Wheelchair Mobility, and/or Ambulation) completed at discharge from rehabilitation and 12 months post-SCI...
March 30, 2018: Archives of Physical Medicine and Rehabilitation
Matthew Nazari, Alice Lee, Jared Rosenblum, Tilak Baba, Samuel Kallus
Primary adenocarcinoma of the small intestine comprises one of the rarest gastrointestinal malignancies. Further, the terminal ileum is very seldom implicated. This entity occurs sporadically and evades traditional colonoscopic evaluation in which the terminal ileum is not visualized. Herein, a case of interval development of primary terminal ileal adenocarcinoma over a 2-year period is reported as followed by direct endoscopic and colonoscopic visualization. This case demonstrates cecal involvement not found on initial evaluation without the provision of terminal ileum intubation...
September 2017: Case Reports in Gastroenterology
Jamie Voyles, Douglas C Woodhams, Veronica Saenz, Allison Q Byrne, Rachel Perez, Gabriela Rios-Sotelo, Mason J Ryan, Molly C Bletz, Florence Ann Sobell, Shawna McLetchie, Laura Reinert, Erica Bree Rosenblum, Louise A Rollins-Smith, Roberto Ibáñez, Julie M Ray, Edgardo J Griffith, Heidi Ross, Corinne L Richards-Zawacki
Infectious diseases rarely end in extinction. Yet the mechanisms that explain how epidemics subside are difficult to pinpoint. We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as it was almost a decade ago. In addition, some species have defenses that are more effective now than they were before the epidemic. These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses...
March 30, 2018: Science
M S Eng, J Kaur, L Prasmickaite, B Ø Engesæter, A Weyergang, E Skarpen, K Berg, M G Rosenblum, G M Mælandsmo, A Høgset, S Ferrone, P K Selbo
Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2). CSPG4 plays an important role in tumor cell growth and survival and promotes chemo- and radiotherapy resistance, suggesting that CSPG4 is an attractive target in cancer therapy. In the present work, we applied the drug delivery technology photochemical internalization (PCI) in combination with the novel CSPG4-targeting immunotoxin 225...
March 22, 2018: Photochemical & Photobiological Sciences
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