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Sonya Meyer, Sara Rosenblum
OBJECTIVE: We compared health-related quality-of-life (HRQOL) perceptions of children with celiac disease (CD) with those of their parents to determine whether their leisure participation differs from that of children without CD and whether relationships exist between leisure participation and HRQOL. METHOD: Children with CD and their parents completed a disease-specific HRQOL self-report questionnaire, the Celiac Disease DUX. These children and matched controls without CD completed the Children's Leisure Assessment Scale (CLASS)...
November 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Michael J Rosenblum
No abstract text is available yet for this article.
October 19, 2016: Journal of General Internal Medicine
Kelly M Cordoro, Derya Ucmak, Maria Hitraya-Low, Michael D Rosenblum, Wilson Liao
No abstract text is available yet for this article.
October 19, 2016: JAMA Dermatology
Daniel F Hanley, Richard E Thompson, John Muschelli, Michael Rosenblum, Nichol McBee, Karen Lane, Amanda J Bistran-Hall, Steven W Mayo, Penelope Keyl, Dheeraj Gandhi, Tim C Morgan, Natalie Ullman, W Andrew Mould, J Ricardo Carhuapoma, Carlos Kase, Wendy Ziai, Carol B Thompson, Gayane Yenokyan, Emily Huang, William C Broaddus, R Scott Graham, E Francois Aldrich, Robert Dodd, Cristanne Wijman, Jean-Louis Caron, Judy Huang, Paul Camarata, A David Mendelow, Barbara Gregson, Scott Janis, Paul Vespa, Neil Martin, Issam Awad, Mario Zuccarello
BACKGROUND: Craniotomy, according to the results from trials, does not improve functional outcome after intracerebral haemorrhage. Whether minimally invasive catheter evacuation followed by thrombolysis for clot removal is safe and can achieve a good functional outcome is not known. We investigated the safety and efficacy of alteplase, a recombinant tissue plasminogen activator, in combination with minimally invasive surgery (MIS) in patients with intracerebral haemorrhage. METHODS: MISTIE was an open-label, phase 2 trial that was done in 26 hospitals in the USA, Canada, the UK, and Germany...
November 2016: Lancet Neurology
Maria Muzik, Diana Morelen, Jessica Hruschak, Katherine Lisa Rosenblum, Erika Bocknek, Marjorie Beeghly
BACKGROUND: The postpartum period represents a major transition in the lives of many women, a time when women are at increased risk for the emergence of psychopathology including depression and PTSD. The current study aimed to better understand the unique contributions of clinically significant postpartum depression, PTSD, and comorbid PTSD/depression on mother-infant bonding and observed maternal parenting behaviors (i.e., behavioral sensitivity, negative affect, positive affect) at 6 months postpartum...
October 3, 2016: Journal of Affective Disorders
Neil M Goldenberg, Benjamin E Steinberg, James T Rutka, Robert Chen, Val Cabral, Norman D Rosenblum, Andras Kapus, Warren L Lee
BACKGROUND: Physicians have traditionally been at the forefront of medical research, bringing clinical questions to the laboratory and returning with ideas for treatment. However, we have anecdotally observed a decline in the popularity of basic science research among trainees. We hypothesized that fewer resident physicians have been pursuing basic science research training over time. METHODS: We examined records from residents in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016)...
July 2016: CMAJ Open
David Levitan, Shunit Gal-Ben-Ari, Christopher Heise, Tali Rosenberg, Alina Elkobi, Sharon Inberg, Carlo Sala, Kobi Rosenblum
The current dogma suggests that the formation of long-term memory (LTM) is dependent on protein synthesis but persistence of the memory trace is not. However, many of the studies examining the effect of protein synthesis inhibitors (PSIs) on LTM persistence were performed in the hippocampus, which is known to have a time-dependent role in memory storage, rather than the cortex, which is considered to be the main structure to store long-term memories. Here we studied the effect of PSIs on LTM formation and persistence in male Wistar Hola (n ≥ 5) rats by infusing the protein synthesis inhibitor, anisomycin (100 μg, 1 μl), into the gustatory cortex (GC) during LTM formation and persistence in conditioned taste aversion (CTA)...
2016: NPJ Sci Learn
Stevan Geoffrey Severtson, Matthew S Ellis, Steven P Kurtz, Andrew Rosenblum, Theodore J Cicero, Mark W Parrino, Michael K Gilbert, Mance E Buttram, Nabarun Dasgupta, Becki BucherBartelson, Jody L Green, Richard C Dart
BACKGROUND: The development of abuse deterrent formulations is one strategy for reducing prescription opioid misuse and abuse. A putative abuse deterrent formulation of oxycodone extended release (OxyContin(®)) was introduced in 2010. Early reports demonstrated reduced abuse and diversion, however, an analysis of social media found 32 feasible methods to circumvent the abuse deterrent mechanism. We measured trends of diversion, abuse and street price of OxyContin to assess the durability of the initial reduction in abuse...
October 3, 2016: Drug and Alcohol Dependence
Roland A Knapp, Gary M Fellers, Patrick M Kleeman, David A W Miller, Vance T Vredenburg, Erica Bree Rosenblum, Cheryl J Briggs
Amphibians are one of the most threatened animal groups, with 32% of species at risk for extinction. Given this imperiled status, is the disappearance of a large fraction of the Earth's amphibians inevitable, or are some declining species more resilient than is generally assumed? We address this question in a species that is emblematic of many declining amphibians, the endangered Sierra Nevada yellow-legged frog (Rana sierrae). Based on >7,000 frog surveys conducted across Yosemite National Park over a 20-y period, we show that, after decades of decline and despite ongoing exposure to multiple stressors, including introduced fish, the recently emerged disease chytridiomycosis, and pesticides, R...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
T J Poorten, E B Rosenblum
In the past century, recently emerged infectious diseases have become major drivers of species decline and extinction. The fungal disease chytridiomycosis has devastated many amphibian populations and exacerbated the amphibian conservation crisis. Biologists are beginning to understand what host traits contribute to disease susceptibility, but more work is needed to determine why some species succumb to chytridiomycosis while others do not. We conducted an integrative laboratory experiment to examine how two toad species respond to infection with the pathogen Batrachochytrium dendrobatidis in a controlled environment...
October 1, 2016: Molecular Ecology
Ling Tong, Wensheng Yu, Craig A Coburn, Lei Chen, Oleg Selyutin, Qingbei Zeng, Michael P Dwyer, Anilkumar G Nair, Bandarpalle B Shankar, Seong Heon Kim, De-Yi Yang, Stuart B Rosenblum, Rebecca T Ruck, Ian W Davies, Bin Hu, Bin Zhong, Jinglai Hao, Tao Ji, Shuai Zan, Rong Liu, Sony Agrawal, Donna Carr, Stephanie Curry, Patricia McMonagle, Karin Bystol, Frederick Lahser, Paul Ingravallo, Shiying Chen, Ernest Asante-Appiah, Joseph A Kozlowski
We describe the impact of proline modifications, in our tetracyclic-indole based series of nonstructural protein 5A (NS5A) inhibitors, to their replicon profiles. This work identified NS5A inhibitors with an improved and flattened resistance profiles.
September 2, 2016: Bioorganic & Medicinal Chemistry Letters
Emme C K Lin, Christopher M Amantea, Tyzoon K Nomanbhoy, Helge Weissig, Junichi Ishiyama, Yi Hu, Shyama Sidique, Bei Li, John W Kozarich, Jonathan S Rosenblum
Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain. Genetic deletion of ERK5 is embryonic lethal, and tissue-restricted deletions have profound effects on erythroid development, cardiac function, and neurogenesis. In addition, depletion of ERK5 is antiinflammatory and antitumorigenic. Small molecule inhibition of ERK5 has been shown to have promising activity in cell and animal models of inflammation and oncology...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
Z A Kohutek, R G Blasberg, J Humm, L E Blumberg, C W Brennan, V Tabar, P H Gutin, B Beattie, M Rosenblum, J T Huse, H Schoder, K Beal
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Ling Tong, Wensheng Yu, Craig A Coburn, Peter T Meinke, Anilkumar G Nair, Michael P Dwyer, Lei Chen, Oleg Selyutin, Stuart B Rosenblum, Yueheng Jiang, James Fells, Bin Hu, Bin Zhong, Richard M Soll, Rong Liu, Sony Agrawal, Ellen Xia, Ying Zhai, Rong Kong, Paul Ingravallo, Amin Nomeir, Ernest Asante-Appiah, Joseph A Kozlowski
Herein, we describe our research efforts to develop unique cores in molecules which function as HCV nonstructural protein 5A (NS5A) inhibitors. In particular, various fused tetracyclic cores were identified which showed genotype and mutant activities comparable to the indole-based tetracyclic core.
October 15, 2016: Bioorganic & Medicinal Chemistry Letters
Norman D Rosenblum
The paper by Jones and colleagues, published in this edition of Clinical Investigative Medicine, contributes to our understanding of Canadian MD/PhD Programs. While there has been little published on this subject by the Canadian programs, themselves, this paper is the most recent in a series by leaders of the Clinical Investigator Trainee Association of Canada (CITAC). The authors are to be commended for their efforts and productivity.
2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
Alison L Miller, Ju-Hyun Song, Julie Sturza, Julie C Lumeng, Katherine Rosenblum, Niko Kaciroti, Delia M Vazquez
Biological and social influences both shape emotion regulation. In 380 low-income children, we tested whether biological stress profile (cortisol) moderated the association among positive and negative home environment factors (routines; chaos) and emotion regulation (negative lability; positive regulation). Children (M age = 50.6, SD = 6.4 months) provided saliva samples to assess diurnal cortisol parameters across 3 days. Parents reported on home environment and child emotion regulation. Structural equation modeling was used to test whether cortisol parameters moderated associations between home environment and child emotion regulation...
September 4, 2016: Developmental Psychobiology
Diana Morelen, Rena Menke, Katherine Lisa Rosenblum, Marjorie Beeghly, Maria Muzik
BACKGROUND: This study examined the bidirectional nature of mother-infant positive and negative emotional displays during social interactions across multiple tasks among postpartum women accounting for childhood maltreatment severity. Additionally, effects of maternal postpartum psychopathology on maternal affect and effects of task and emotional valence on dyadic emotional displays were evaluated. SAMPLING AND METHODS: A total of 192 mother-infant dyads (51% male infants) were videotaped during free play and the Still-Face paradigm at 6 months postpartum...
September 1, 2016: Psychopathology
Ellen McGinnis, Ryan McGinnis, Maria Muzik, Jessica Hruschak, Nestor Lopez-Duran, Noel Perkins, Kate Fitzgerald, Katherine Rosenblum
Temporal phases of threat response including Potential Threat (Anxiety), Acute Threat (Startle, Fear), and Post-threat Response Modulation have been identified as underlying markers of anxiety disorders. Objective measures of response during these phases may help identify children at risk for anxiety, however the complexity of current assessment techniques prevent their adoption in many research and clinical contexts. We propose an alternative technology, an inertial measurement unit (IMU), that enables non-invasive measurement of the movements associated with threat response, and test its ability to detect threat response phases in young children at heightened risk for developing anxiety...
August 25, 2016: IEEE Journal of Biomedical and Health Informatics
A Q Byrne, J Voyles, G Rios-Sotelo, E B Rosenblum
Advances in genetics and genomics have provided new tools for the study of emerging infectious diseases. Researchers can now move quickly from simple hypotheses to complex explanations for pathogen origin, spread, and mechanisms of virulence. Here we focus on the application of genomics to understanding the biology of the fungal pathogen Batrachochytrium dendrobatidis (Bd), a novel and deadly pathogen of amphibians. We provide a brief history of the system, then focus on key insights into Bd variation garnered from genomics approaches, and finally, highlight new frontiers for future discoveries...
2016: Progress in Molecular Biology and Translational Science
Tyzoon K Nomanbhoy, Geeta Sharma, Heidi Brown, Jiangyue Wu, Arwin Aban, Subha Vogeti, Senait Alemayehu, Maria Sykes, Jonathan S Rosenblum, John W Kozarich
Palbociclib is a cyclin-dependent kinase (CDK) 4/CDK6 inhibitor approved for breast cancer that is estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative. We profiled palbociclib in cells either sensitive or resistant to the drug using an ATP/ADP probe-based chemoproteomics platform. Palbociclib only engaged CDK4 or CDK6 in sensitive cells. In resistant cells, no inhibition of CDK4 or CDK6 was observed, although the off-target profiles were similar in both cell types. Prolonged incubation of sensitive cells with the compound (24 h) resulted in the downregulation of additional kinases, including kinases critical for cell cycle progression...
September 27, 2016: Biochemistry
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