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https://www.readbyqxmd.com/read/29141020/genomic-analysis-of-atypical-fibroxanthoma
#1
Kevin Lai, Catherine A Harwood, Karin J Purdie, Charlotte M Proby, Irene M Leigh, Namita Ravi, Thaddeus W Mully, Lionel Brooks, Priscilla M Sandoval, Michael D Rosenblum, Sarah T Arron
Atypical fibroxanthoma (AFX), is a rare type of skin cancer affecting older individuals with sun damaged skin. Since there is limited genomic information about AFX, our study seeks to improve the understanding of AFX through whole-exome and RNA sequencing of 8 matched tumor-normal samples. AFX is a highly mutated malignancy with recurrent mutations in a number of genes, including COL11A1, ERBB4, CSMD3, and FAT1. The majority of mutations identified were UV signature (C>T in dipyrimidines). We observed deletion of chromosomal segments on chr9p and chr13q, including tumor suppressor genes such as KANK1 and CDKN2A, but no gene fusions were found...
2017: PloS One
https://www.readbyqxmd.com/read/29132208/organic-chemical-characterization-and-mass-balance-of-a-hydraulically-fractured-well-from-fracturing-fluid-to-produced-water-over-405-days
#2
James S Rosenblum, E Michael Thurman, Imma Ferrer, George R Aiken, Karl G Linden
A long-term field study (405 days) of a hydraulically fractured well from the Niobrara Formation in the Denver-Julesburg Basin was completed. Characterization of organic chemicals used in hydraulic fracturing and their changes through time, from the pre-injected fracturing fluid to the produced water, was conducted. The characterization consisted of a mass balance by dissolved organic carbon (DOC), volatile organic analysis by gas chromatography/mass spectrometry, and nonvolatile organic analysis by liquid chromatography/mass spectrometry...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29124929/injectable-polymeric-cytokine-binding-nanowires-are-effective-tissue-specific-immunomodulators
#3
Colin R Zamecnik, Margaret M Lowe, David M Patterson, Michael D Rosenblum, Tejal A Desai
Injectable nanomaterials that interact with the host immune system without surgical intervention present spatially anchored complements to cell transplantation and could offer improved pharmacokinetics compared to systemic cytokine therapy. Here we demonstrate fabrication of high aspect ratio polycaprolactone nanowires coupled with cytokine-binding antibodies that assemble into porous matrices when injected into the subcutaneous space. These structures are fabricated using a nanotemplating technique that allows for tunability of particle dimensions and utilize a straightforward maleimide conjugation chemistry to allow site-specific coupling to proteins...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29123478/neural-synchronization-from-the-perspective-of-non-linear-dynamics
#4
Ramon Guevara Erra, Jose L Perez Velazquez, Michael Rosenblum
No abstract text is available yet for this article.
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29119645/high-sensitivity-of-fish-analysis-in-detecting-homozygous-smarcb1-deletions-in-poorly-differentiated-chordoma-a-clinicopathologic-and-molecular-study-of-9-cases
#5
Adepitan A Owosho, Lei Zhang, Marc K Rosenblum, Cristina R Antonescu
Poorly differentiated chordomas (PDCs) represent a rare subset of notochordal neoplasms, affecting primarily children and associated with an aggressive outcome. In contrast to conventional chordomas, PDC show solid growth and increased cellularity, cytologic atypia, and mitotic activity. Recent studies have shown that PDCs are characterized by recurrent deletions encompassing the SMARCB1 locus, resulting in consistent loss of nuclear SMARCB1 expression. Thus PDC joined the expanding family of SMARCB1-deficient tumors characterized by various SMARCB1 structural abnormalities, ranging from large homozygous deletions to small intragenic mutations...
November 9, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29119046/hemorrhagic-intracranial-follicular-dendritic-cell-sarcoma-a-case-report
#6
Neil Haranhalli, Adam E Ammar, Karen M Weidenheim, Marc K Rosenblum, David J Altschul
Background: Follicular dendritic cell (FDC) sarcoma is an extremely rare neoplasm, which has only been reported once in the literature with an intracranial occurrence. Neither hemorrhagic presentation of an intracranial instance of FDC sarcoma nor its rapid recurrence has yet been published in the literature. Case Description: We report the case of a 61-year-old female who presented with confusion and headaches secondary to a right frontal hemorrhagic lesion, and her subsequent presentations for recurrence of the lesion and finding of a new intracranial lesion...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29110373/correction
#7
Elizabeth Colantuoni, Michael Rosenblum
No abstract text is available yet for this article.
November 30, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29109083/activated-hedgehog-gli-signaling-causes-congenital-ureteropelvic-junction-obstruction
#8
Sepideh Sheybani-Deloui, Lijun Chi, Marian V Staite, Jason E Cain, Brain J Nieman, R Mark Henkelman, Brandon J Wainwright, S Steven Potter, Darius J Bagli, Armando J Lorenzo, Norman D Rosenblum
Intrinsic ureteropelvic junction obstruction is the most common cause of congenital hydronephrosis, yet the underlying pathogenesis is undefined. Hedgehog proteins control morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation of the GLI3 transcriptional repressor. Hedgehog regulates differentiation and proliferation of ureteric smooth muscle progenitor cells during murine kidney-ureter development. Histopathologic findings of smooth muscle cell hypertrophy and stroma-like cells, consistently observed in obstructing tissue at the time of surgical correction, suggest that Hedgehog signaling is abnormally regulated during the genesis of congenital intrinsic ureteropelvic junction obstruction...
November 6, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29061458/unilateral-symptomatic-hypertrophic-olivary-degeneration-secondary-to-midline-brainstem-cavernous-angioma-a-case-report-and-review-of-the-literature
#9
Jared Rosenblum, Matt Nazari, Yasir Al-Khalili, Valeria Potigailo, Erol Veznedaroglu
BACKGROUND: Hypertrophic olivary degeneration (HOD) is a rare phenomenon in the dento-rubro-olivary pathway due to lesion or disruption of the fibers of the Guillain-Mollaret Triangle. Hemorrhage of pontine and midbrain cavernous angiomas rarely can lead to hypertrophic olivary degeneration (HOD) portending neurological deterioration and possible concomitant life-threatening complications; for this reason, it may define a poignant consideration in planning intervention. CASE DESCRIPTION: 57-year-old female with known midbrain-pontine cavernous angioma...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29061226/scientific-overview-on-csci-citac-annual-general-meeting-and-2016-young-investigators-forum
#10
Tianwei E Zhou, Kristen I Barton, Elina Cook, Matthew G K Benesch, Nicholas Jette, Christophe Moderie, Katarina Ondrusova, Caitlin Lees, Patrick E Steadman, Tina B Marvasti, Sara Mirali, Peter J Liu, Ege M Babadagli, Kara J Abraham, Kirill J Zaslavsky
The 2016 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national conference held in Toronto November 21-23, 2016, in conjunction with The University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Mapping Your Career as a Clinician-Scientist"; emphasizing essential skills for developing a fruitful career as clinician-scientist...
October 19, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/29059150/protein-phosphatase-1-regulatory-subunit-1a-in-ewing-sarcoma-tumorigenesis-and-metastasis
#11
W Luo, C Xu, J Ayello, F Dela Cruz, J M Rosenblum, S L Lessnick, M S Cairo
Protein phosphatase inhibitors are often considered as tumor promoters. Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor; however, its role in tumor development is largely undefined. Here we characterize, for the first time, the functions of PPP1R1A in Ewing sarcoma (ES) pathogenesis. We found that PPP1R1A is one of the top ranked target genes of EWS/FLI, the master regulator of ES, and is upregulated by EWS/FLI via a GGAA microsatellite enhancer element...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29039796/development-and-validation-of-the-celiac-disease-children-s-activities-report-cd-chart-for-promoting-self-management-among-children-and-adolescents
#12
Sonya Meyer, Sara Rosenblum
Adherence to a restrictive gluten-free diet is the only known treatment for celiac disease (CD). Children and adolescents with CD encounter challenges while managing the diet in daily activities. Understanding their participation characteristics is lacking. The aim was to describe the development and validation process of the Celiac Disease-Children's Activities Report (CD-Chart). The final CD-Chart includes nine food-related activities that are measured by six core dimensions: frequency, preference, preparation, involvement, help, and self-determination...
October 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29028122/atypical-alk-positive-spitz-tumors-with-9p21-homozygous-deletion-report-of-two-cases-and-review-of-the-literature
#13
Andrew J Rand, Wendy L Flejter, Christopher A Dowling, Linda M Brooke, Genevieve M Boland, Daniela Kroshinsky, Isaac R Rosenblum, Marier Hernandez-Perez, Julie D R Reimann
ALK rearrangements occur in up to 10% of spitzoid melanocytic neoplasms. No reported cases have shown homozygous deletion of 9p21 (CDKN2A) or gains of 6p25 (RREB1) or 11q13 (CCND1), which have been associated with aggressive clinical behavior. Here we report two unique cases. Case 1 occurred in a 9-year-old male with a 14-mm nodule on the anterior left thigh. Biopsy revealed an ALK-positive Spitz tumor containing an irregular nodule of densely packed melanocytes with increased mitoses and loss of p16 immunoreactivity...
October 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28994415/sci-peer-health-coach-influence-on-self-management-with-peers-a-qualitative-analysis
#14
S E Skeels, D Pernigotti, B V Houlihan, T Belliveau, M Brody, J Zazula, S Hasiotis, S Seetharama, D Rosenblum, A Jette
STUDY DESIGN: A process evaluation of a clinical trial. OBJECTIVES: To describe the roles fulfilled by peer health coaches (PHCs) with spinal cord injury (SCI) during a randomized controlled trial research study called 'My Care My Call', a novel telephone-based, peer-led self-management intervention for adults with chronic SCI 1+ years after injury. SETTING: Connecticut and Greater Boston Area, MA, USA. METHODS: Directed content analysis was used to qualitatively examine information from 504 tele-coaching calls, conducted with 42 participants with SCI, by two trained SCI PHCs...
November 2017: Spinal Cord
https://www.readbyqxmd.com/read/28990704/epithelioid-glioblastomas-stratify-into-established-diagnostic-subsets-upon-integrated-molecular-analysis
#15
Andrey Korshunov, Lukas Chavez, Tanvi Sharma, Marina Ryzhova, Daniel Schrimpf, Damian Stichel, David Capper, Dominik Sturm, Marcel Kool, Antje Habel, Bette K Kleinschmidt-DeMasters, Marc Rosenblum, Oksana Absalyamova, Andrey Golanov, Peter Lichter, Stefan M Pfister, David T W Jones, Arie Perry, Andreas von Deimling
Epithelioid glioblastoma (eGBM) is a newly defined and rare GBM variant in the current WHO 2016 classification. BRAF V600E mutation is overrepresented in these tumors and there is known some morphological overlap with anaplastic epithelioid PXA (ePXA). In order to further elucidate this diagnostic category, we molecularly characterized 64 pediatric and adult examples initially diagnosed as "eGBM". Tumors were analyzed using array based methylation and direct sequencing of the BRAF and TERT genes. Our results demonstrated considerable molecular and clinical heterogeneity among eGBM cohort...
October 9, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28959154/pelvic-organ-prolapse-considerations-in-surgical-management-nyu-case-of-the-month-april-2017
#16
Nirit Rosenblum
No abstract text is available yet for this article.
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28936602/improving-maternal-representations-in-high-risk-mothers-a-randomized-controlled-trial-of-the-mom-power-parenting-intervention
#17
Katherine Rosenblum, Jamie Lawler, Emily Alfafara, Nicole Miller, Melisa Schuster, Maria Muzik
A key mechanism of risk transmission between maternal risk and child outcomes are the mother's representations. The current study examined the effects of an attachment-based, trauma-informed parenting intervention, the Mom Power (MP) program, in optimizing maternal representations of high-risk mothers utilizing a randomized, controlled trial design (NCT01554215). High-risk mothers were recruited from low-income community locations and randomized to either the MP Intervention (n = 42) or a control condition (n = 33) in a parallel design...
September 21, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28884138/chronic-helicobacter-cinaedi-cellulitis-diagnosed-by-microbial-polymerase-chain-reaction
#18
Andrew Matsumoto, Iwei Yeh, Brian Schwartz, Michael Rosenblum, Timothy H Schmidt
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28880949/maternal-hypothalamic-pituitary-adrenal-axis-response-to-foraging-uncertainty-a-model-of-individual-vs-social-allostasis-and-the-superorganism-hypothesis
#19
Jeremy D Coplan, Nishant K Gupta, Asif Karim, Anna Rozenboym, Eric L P Smith, John G Kral, Leonard A Rosenblum
INTRODUCTION: Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable foraging demand (VFD) activates corticotropin-releasing factor (CRF) without eliciting hypothalamic-pituitary-adrenal (HPA) activation measured on a group level. Individual homeostatic adaptations of the HPA axis may subserve second-order homeostasis, a process we provisionally term "social allostasis." We postulate that maternal food insecurity induces a "superorganism" state through coordination of individual HPA axis response...
2017: PloS One
https://www.readbyqxmd.com/read/28860036/effect-of-chlorination-by-products-on-the-quantitation-of-microcystins-in-finished-drinking-water
#20
Laura Rosenblum, Alan Zaffiro, William A Adams, Steven C Wendelken
Microcystins are toxic peptides that can be produced by cyanobacteria in harmful algal blooms (HABs). Various analytical techniques have been developed to quantify microcystins in drinking water, including liquid chromatography tandem mass spectrometry (LC/MS/MS), enzyme linked immunosorbent assay (ELISA), and oxidative cleavage to produce 2-methyl-3-methoxy-4-phenylbutyric acid (MMPB) with detection by LC/MS/MS, the "MMPB method". Both the ELISA and MMPB methods quantify microcystins by detecting a portion of the molecule common to most microcystins...
November 2017: Toxicon: Official Journal of the International Society on Toxinology
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