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Early psychosis

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https://www.readbyqxmd.com/read/29770569/frontal-cortical-thickness-correlates-positively-with-impulsivity-in-early-psychosis-male-patients
#1
Philipp S Baumann, Paul Klauser, Alessandra Griffa, Philippe Golay, Julie Palix, Luis Alameda, Valérie Moulin, Patric Hagmann, Kim Q Do, Philippe Conus
AIM: Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophrenia have been poorly investigated especially in young adults, the aim of this study was to investigate the relationship between impulsivity and cortical thickness in early psychosis (EP) patients. METHOD: A total of 17 male subjects in the early phase of psychosis were recruited...
May 17, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29767457/suicidal-behavior-and-personality-traits-contribute-to-disability-in-first-episode-psychosis-a-1-year-follow-up-study
#2
Manuel Canal-Rivero, Javier-David Lopez-Moriñigo, Maria-Luisa Barrigón, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro, Miguel Ruiz-Veguilla, Jordi E Obiols-Llandrich
BACKGROUND: Disability encompasses impairments, activity limitations, and restrictions on participation. Improvement in functioning has therefore become a crucial outcome of treatment in psychosis. OBJECTIVE: The main aim of this study was to analyze the potential relationship between suicidal behavior after first episode of psychosis (FEP) and family disability. The second aim was to find out whether personality traits are associated with disability dimensions...
May 16, 2018: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/29764759/development-and-validation-of-the-client-engagement-and-service-use-scale-a-pilot-study
#3
Emily R Kline, Nicole R DeTore, Kristen Keefe, Larry J Seidman, Vinod H Srihari, Matcheri S Keshavan, Margaret Guyer
Specialized treatment for first episode psychosis offers clients a menu of services coordinated within a specialized treatment team. To enhance the impact of these services, promoting engagement and preventing early treatment drop-out is critical. However, engagement is poorly tracked and typically quantified through proxy variables such as session attendance, medication adherence, or working alliance. The aim of this study is to introduce and pilot a new measure of engagement for first episode psychosis coordinated specialty care, the Client Engagement and Service Use Scale (CENSUS)...
May 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29759055/results-of-a-coordinated-specialty-care-program-for-early-psychosis-and-predictors-of-outcomes
#4
Ilana Nossel, Melanie M Wall, Jennifer Scodes, Leslie A Marino, Sacha Zilkha, Iruma Bello, Igor Malinovsky, Rufina Lee, Marleen Radigan, Thomas E Smith, Lloyd Sederer, Gyojeong Gu, Lisa Dixon
OBJECTIVE: This study prospectively evaluated outcomes of OnTrackNY, a statewide coordinated specialty care (CSC) program for treatment of early psychosis in community settings, as well as predictors of outcomes. METHODS: The sample included 325 individuals ages 16-30 with recent-onset nonaffective psychosis who were enrolled in OnTrackNY and who had at least one three-month follow-up. Clinicians provided data at baseline and quarterly up to one year. Domains assessed included demographic and clinical characteristics, social and occupational functioning, medications, suicidality and violence, hospitalization, and time to intervention...
May 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29756462/lgi1-antibody-encephalitis-and-psychosis
#5
Dahai Wang, Qinjian Hao, Lan He, Qiang Wang
OBJECTIVE: To describe a case of leucine-rich, glioma inactivated 1 antibody-encephalitis presenting with psychosis. METHODS: Case report. RESULTS: A young man with leucine-rich, glioma inactivated 1-antibody encephalitis initially presented with acute psychotic symptoms, short-term memory loss and faciobrachial dystonic seizures. Magnetic resonance imaging revealed hippocampal lesions. Electroencephalography revealed frontotemporal slowing of background activity...
May 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29754121/early-intervention-services-in-greece-time-to-focus-on-people-at-high-risk
#6
S I Bargiota, V P Bozikas, G Garyfallos, P McGuire
Over the last twenty years, a lot of early intervention services operate worldwide with the aim of offering assistance and promoting the early diagnosis and management, not only of people who experience a first episode of psychosis but also of individuals that are at high risk of developing psychosis. The early intervention services that operate in other countries have been reviewed in correlation with the current status of early intervention services for psychosis in Greece. Early intervention services were first established in Australia, and now hundreds of similar programs exist in Europe, North America and Asia...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29748632/chronic-cannabis-promotes-pro-hallucinogenic-signaling-of-5-ht2a-receptors-through-akt-mtor-pathway
#7
Inés Ibarra-Lecue, Irene Mollinedo-Gajate, J Javier Meana, Luis F Callado, Rebeca Diez-Alarcia, Leyre Urigüen
Long-term use of potent cannabis during adolescence increases the risk of developing schizophrenia later in life, but to date, the mechanisms involved remain unknown. Several findings suggest that the functional selectivity of serotonin 2A receptor (5-HT2AR) through inhibitory G-proteins is involved in the molecular mechanisms responsible for psychotic symptoms. Moreover, this receptor is dysregulated in the frontal cortex of schizophrenia patients. In this context, studies involving cannabis exposure and 5-HT2AR are scarce...
April 27, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29746524/evaluating-verbal-learning-and-memory-in-patients-with-an-at-risk-mental-state-or-first-episode-psychosis-using-structural-equation-modelling
#8
Laura Egloff, Erich Studerus, Ronan Zimmermann, Ulrike Heitz, Stephanie Menghini-Müller, Sarah Ittig, Katharina Beck, Christina Andreou, Stefan Borgwardt, Anita Riecher-Rössler
BACKGROUND: Verbal learning and memory are impaired not only in patients with a first episode of psychosis (FEP) but also-to a lower extent-in those with an at-risk mental state for psychosis (ARMS). However, little is known about the specific nature of these impairments. Hence, we aimed to study learning and memory processes in ARMS and FEP patients by making use of structural equation modelling. METHODS: Verbal learning was assessed with the California Verbal Learning Test (CVLT) in 98 FEP patients, 126 ARMS patients and 68 healthy controls (HC) as part of the Basel early detection of psychosis (FePsy) study...
2018: PloS One
https://www.readbyqxmd.com/read/29740953/recent-violence-and-legal-involvement-among-young-adults-with-early-psychosis-enrolled-in-coordinated-specialty-care
#9
Stephanie A Rolin, Leslie A Marino, Leah G Pope, Michael T Compton, Rufina J Lee, Barry Rosenfeld, Merrill Rotter, Ilana Nossel, Lisa Dixon
AIM: Individuals with serious mental illnesses have a small increased risk of engaging in violence or legal involvement compared to the general population. This seems to be particularly true for young adults experiencing early stages of psychosis. This study analysed the prevalence of and risk factors for reports of violence and legal involvement in a sample of young adults receiving Coordinated Specialty Care for early non-affective psychosis. METHODS: A total of 373 young adults (ages 16-30) within 2 years of the onset of non-affective psychosis were enrolled in 10 Coordinated Specialty Care sites in New York State from October 2013 to August 2016...
May 9, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29740359/profiling-of-amino-acids-and-their-derivatives-biogenic-amines-before-and-after-antipsychotic-treatment-in-first-episode-psychosis
#10
Liisa Leppik, Kärt Kriisa, Kati Koido, Kadri Koch, Kärolin Kajalaid, Liina Haring, Eero Vasar, Mihkel Zilmer
Schizophrenia (SCH) is a heterogeneous disorder, deriving from a potential multitude of etiopathogenetic factors. During the past few years there has been an increasing interest in the role of circulating amino acids (AAs) and biogenic amines (BAs) in the pathophysiology of SCH. In the present study, we aimed to provide an insight into the potential role of alterations in levels of AAs and BAs as well as examine their more specific metabolic shifts in relation to early stage of SCH. We measured 21 AAs and 17 BAs in serum samples of patients with first-episode psychosis (FEP) before and after 7-month antipsychotic treatment in comparison to control subjects (CSs)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29730662/anomalous-self-experiences-markers-of-schizophrenia-vulnerability-or-symptoms-of-depersonalization-disorder-a-phenomenological-investigation-of-two-cases
#11
Tor Gunnar Værnes, Jan Ivar Røssberg, Paul Møller
BACKGROUND: Basic self-disturbance (BSD) is proposed to constitute the clinical core of schizophrenia spectrum disorders, including prodromal states and schizotypy. Anomalous self-experiences (ASEs) are suggested as phenotypic variants of BSD, representing markers of schizophrenia vulnerability. However, ASEs are not restricted to the schizophrenia spectrum, but may also occur in non-psychotic states like depersonalization disorder (DPD). It is unclear to what extent the prevalence and nature of ASEs are differing between the two conditions...
May 4, 2018: Psychopathology
https://www.readbyqxmd.com/read/29728871/psychological-interventions-in-psychosis-in-children-and-adolescents-a-systematic-review
#12
REVIEW
Nefeli Anagnostopoulou, Marinos Kyriakopoulos, Anca Alba
BACKGROUND: Early onset psychosis (EOP), referring to psychosis with onset before the age of 18 years, is a more severe form of psychosis associated with worse prognosis. While medication is the treatment of choice, psychological interventions are also considered to have an important role in the management of symptoms and disability associated with this condition. The present review aimed to explore the effectiveness of such interventions. METHOD: An electronic search was conducted on the Embase, Medline, and PsychInfo databases for papers of randomized controlled trials (RCTs) referring to psychological interventions in EOP...
May 4, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29726625/sharing-information-about-diagnosis-and-outcome-of-first-episode-psychosis-in-patients-presenting-to-early-intervention-services
#13
Saeed Farooq, Debra J Green, Swaran P Singh
AIM: First-episode psychosis (FEP) can be a serious and debilitating disease, but there is limited literature on how to inform patients and carers about its diagnosis and outcome. We aimed to examine the attitudes, practices and views of clinicians working in Early Intervention Service about sharing information on diagnosis and outcome of FEP. METHODS: A 26-item questionnaire was sent electronically to clinical staff who have been involved in the discussion of FEP diagnosis in Early Intervention Services in the West Midlands, UK...
May 4, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29723343/early-psychiatric-morbidity-in-a-brazilian-sample-of-acute-ischemic-stroke-patients
#14
Vinicius S P Pedroso, Andre R Brunoni, Érica L M Vieira, Ricardo E Jorge, Edward C Lauterbach, Antonio L Teixeira
OBJECTIVE: Stroke is a major public health problem worldwide, and its neuropsychiatric sequelae are frequent and disabling. Furthermore, there is evidence that these sequelae impair recovery. Brazil has the highest stroke rates in Latin America, but data on the frequency of neuropsychiatric disorders in these patients are scarce. This study aimed to identify mental disorders among in-hospital patients with acute ischemic stroke. METHODS: The Mini International Neuropsychiatric Interview-Plus (MINI-Plus) was applied to 60 patients during the first week of hospitalization...
2018: Clinics
https://www.readbyqxmd.com/read/29717820/mobile-intensive-care-unit-a-case-management-team-dedicated-to-early-psychosis-in-france
#15
Laurent Lecardeur, Sophie Meunier-Cussac, Sonia Dollfus
AIM: To present the activities of a Mobile Intensive Care Unit in France. METHODS: We summarize participant recruitment as well as the diagnostic procedures and therapeutic interventions offered to individuals with an at-risk mental state or first-episode psychosis (FEP). RESULTS: Since its inception in 2010, 266 individuals from 16 to 30 years old living in an area of 120 000 citizens have been recruited by the Mobile Intensive Care Unit...
May 2, 2018: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29717522/brain-morphologic-changes-in-early-stages-of-psychosis-implications-for-clinical-application-and-early-intervention
#16
Tsutomu Takahashi, Michio Suzuki
To date, a large number of magnetic resonance imaging (MRI) studies have been conducted in schizophrenia, which generally demonstrate gray matter reduction predominantly in the frontal and temporo-limbic regions, as well as gross brain abnormalities (e.g., a deviated sulcogyral pattern). Although the causes as well as timing and course of these findings remain elusive, these morphologic changes (especially gross brain abnormalities and medial temporal lobe atrophy) are likely present at illness onset, possibly reflecting early neurodevelopmental abnormalities...
May 1, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29715654/relationship-between-the-duration-of-methamphetamine-use-and-psychotic-symptoms-a-two-year-prospective-cohort-study
#17
Jun Ma, Xiao-Dong Li, Tong-Yu Wang, Su-Xia Li, Shi-Qiu Meng, Frederic C Blow, Mark Ilgen, Louisa Degenhardt, Julia Lappin, Ping Wu, Jie Shi, Yan-Ping Bao, Lin Lu
BACKGROUND: Psychosis is a key harm associated with methamphetamine (MA) use. This study examined the relationship between the duration of MA use and risk of psychotic symptoms. METHODS: A cohort of 528 individuals with chronic MA use was followed for two years after leaving treatment center in Guangdong, China. Psychotic symptoms were assessed using the Positive and Negative Syndrome Scale at baseline and four follow-up visits (6, 12, 18 and 24 months after baseline)...
April 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29712475/developmental-delay-treatment-resistant-psychosis-and-early-onset-dementia-in-a-man-with-22q11-deletion-syndrome-and-huntington-s-disease
#18
Martilias Farrell, Maya Lichtenstein, James J Crowley, Dawn M Filmyer, Gabriel Lázaro-Muñoz, Rita A Shaughnessy, Ian R Mackenzie, Veronica Hirsch-Reinshagen, Robert Stowe, James P Evans, Jonathan S Berg, Jin Szatkiewicz, Richard C Josiassen, Patrick F Sullivan
No abstract text is available yet for this article.
May 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29710118/disorganized-gyrification-network-properties-during-the-transition-to-psychosis
#19
Tushar Das, Stefan Borgwardt, Daniel J Hauke, Fabienne Harrisberger, Undine E Lang, Anita Riecher-Rössler, Lena Palaniyappan, André Schmidt
Importance: There is urgent need to improve the limited prognostic accuracy of clinical instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis. As yet, no reliable biological marker has been established to delineate CHR individuals who will develop psychosis from those who will not. Objectives: To investigate abnormalities in a graph-based gyrification connectome in the early stages of psychosis and to test the accuracy of this systems-based approach to predict a transition to psychosis among CHR individuals...
April 25, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29708310/early-intervention-for-everyone-a-review-of-cross-cultural-issues-and-their-treatment-in-ultra-high-risk-uhr-cohorts
#20
REVIEW
Valentina Deriu, Marie Rose Moro, Laelia Benoit
AIM: Over the past 20 years, early management of psychosis has become both a research and policy priority. In Western countries, psychotic disorders appear more prevalent in migrant and minority ethnic groups than in native or dominant groups. Moreover, disparities exist in health conditions and access to care among immigrants and minority ethnic groups, compared with native-born and majority groups. Appropriate early detection tools are necessary for the different groups. METHODS: This systematic review provides a synthesis of the assessment and discussion of transcultural issues in ultra-high-risk (UHR) cohorts...
April 30, 2018: Early Intervention in Psychiatry
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