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Early psychosis

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https://www.readbyqxmd.com/read/28805579/nonmotor-manifestations-of-wilson-s-disease
#1
Samar Biswas, Neelanjana Paul, Shyamal K Das
Wilson disease (WD) is an autosomal genetic disorder characterized by excessive copper deposition initially in liver (hepatic variant) followed by brain (neuropsychiatric variant) and other organs such as cornea and kidney due to defect in biliary copper excretion. Predominant presentations of neuropsychiatric variant are extrapyramidal motor dysfunctions such as dystonias, Parkinsonism, choreoathetosis, tremor, and ataxias. Nonmotor symptoms (NMS) can appear before clinical disease expression and during ongoing disease process...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803848/disengagement-in-immigrant-groups-receiving-services-for-a-first-episode-of-psychosis
#2
Anika Maraj, Franz Veru, Laura Morrison, Ridha Joober, Ashok Malla, Srividya Iyer, Jai Shah
OBJECTIVE: Although early intervention (EI) programs for psychosis invest in clients remaining engaged in treatment, disengagement remains a concern. It is not entirely clear whether immigrants are likelier to disengage. The rates and predictors of disengagement for immigrant vis-à-vis non-immigrant clients in a Canadian EI setting were analyzed. METHOD: 297 clients were included in a time-to-event analysis with Cox Proportional Hazards regression models. Immigrant status (first- or second-generation immigrant or non-immigrant), age, gender, education, substance abuse, family contact, social and material deprivation and medication non-adherence were tested as predictors of service disengagement...
August 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28803040/attachment-and-thought-problems-in-an-adolescent-inpatient-sample-the-mediational-role-of-theory-of-mind
#3
Jessica R Hart, Amanda Venta, Carla Sharp
BACKGROUND: Previous research has documented increased incidence of insecure attachment and theory of mind (ToM) deficits in individuals experiencing psychotic disorders. ToM has been theorized as a possible mediator of the relation between attachment and psychosis (Korver-Nieberg et al., 2014). The current study sought to extend this area of research to adolescents for the first time by examining adolescent-parent attachment and ToM in inpatient adolescents. METHODS: Participants were 362 inpatient adolescents and their parents; participants completed the Child Attachment Interview, Movie for the Assessment of Social Cognition, Youth Self Report, and Child Behavior Checklist...
July 13, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28799518/a-neurodevelopment-and-neuroplasticity-based-framework-for-early-intervention-in-psychotic-disorders
#4
E Bora
In recent years there has been growing interest in early intervention in psychotic disorders and a number of clinical and research programmes have been developed. The clinical staging model has been an essential part of early intervention as it provides the rationale of existing programmes. In medicine, clinical staging is a valuable approach in disorders where primary pathology is progressive in nature. However, the clinical staging model of psychosis has been proposed without establishing first that schizophrenia is a primarily progressive disorder...
August 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28796022/a-pilot-study-of-the-usefulness-of-a-single-olanzapine-plasma-concentration-as-an-indicator-of-early-drug-effect-in-a-small-sample-of-first-episode-psychosis-patients
#5
Arantzazu Zabala, Mariana Bustillo, Imanol Querejeta, Marta Alonso, Oiane Mentxaka, Ana González-Pinto, Amaia Ugarte, J Javier Meana, Miguel Gutiérrez, Rafael Segarra
PURPOSE/BACKGROUND: Studies analyzing concentration-effect relationships in second-generation antipsychotics have reported contradictory results in chronic schizophrenia. No data are available for the early stages of the disease. The present study aims to evaluate the association between a single olanzapine plasma concentration, clinical response, and severity of adverse effects in first-episode psychosis (FEP); to test the utility of various plasma breakpoints as markers of early response to treatment; and to identify variables affecting olanzapine concentrations...
August 8, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28792114/early-psychosis-workforce-development-core-competencies-for-mental-health-professionals-working-in-the-early-psychosis-field
#6
Helen Osman, Anthony F Jorm, Eoin Killackey, Shona Francey, Dianne Mulcahy
AIM: The aim of this study was to identify the core competencies required of mental health professionals working in the early psychosis field, which could function as an evidence-based tool to support the early psychosis workforce and in turn assist early psychosis service implementation and strengthen early psychosis model fidelity. METHOD: The Delphi method was used to establish expert consensus on the core competencies. In the first stage, a systematic literature search was conducted to generate competency items...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28792113/the-role-of-a-family-history-of-psychosis-for-youth-at-clinical-high-risk-of-psychosis
#7
Grace Georgopoulos, Jacqueline Stowkowy, Lu Liu, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Thomas H McGlashan, Diana O Perkins, Larry J Seidman, Ming T Tsuang, Elaine F Walker, Scott W Woods, Carrie E Bearden, Daniel H Mathalon, Jean Addington
AIM: On average, there is a 10% to 12% likelihood of developing a psychotic disorder solely based on being at familial high risk. However, the introduction of the criteria for clinical high risk (CHR) of psychosis suggested for CHR individuals, 20% to 30% will go on to develop a full-blown psychotic illness within 3 years. Several studies suggest a role for family history in conversion to psychosis among those at CHR. However, we know very little about those who meet the CHR criteria and have a positive family history for psychosis compared to those at CHR with no known family history...
August 9, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28782283/psychosis-risk-screening-in-different-populations-using-the-prodromal-questionnaire-a-systematic-review
#8
REVIEW
Mark Savill, Jennifer D'Ambrosio, Tyrone D Cannon, Rachel L Loewy
AIM: Diagnosing individuals at ultra high risk (UHR) for psychosis can improve early access to treatment, and a two-stage model utilizing self-report screening followed by a clinical interview can be accurate and efficient. However, it is currently unclear which screening cut-offs to adopt with different populations. METHODS: A systematic review of diagnostic accuracy studies evaluating the Prodromal Questionnaire (PQ) as a preliminary screener for UHR and psychosis was conducted to examine screening effectiveness in different contexts...
August 6, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28777028/preliminary-validation-of-a-clinical-staging-model-in-schizophrenia-and-related-disorders
#9
Amy Tedja, Eva Velthorst, Mirjam van Tricht, Lieuwe de Haan
Clinical staging for schizophrenia and related disorders might provide an ideal means to overcome some limitations of the current diagnostic system and to facilitate early intervention. This study aims to retrospectively explore 1) the validity of a staging model 2) the stability of staging over time, and 3) the clinical factors associated with transition to more chronic stages. Data were derived from the Genetic Risk and Outcome of Psychosis study, a large cohort study of patients with a schizophrenia spectrum disorder...
August 4, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28776162/treatment-for-negative-symptoms-in-schizophrenia-a-comprehensive-review
#10
REVIEW
Selene R T Veerman, Peter F J Schulte, Lieuwe de Haan
Negative symptoms (such as amotivation and diminished expression) associated with schizophrenia are a major health concern. Adequate treatment would mean important progress with respect to quality of life and participation in society. Distinguishing primary from secondary negative symptoms may inform treatment options. Primary negative symptoms are part of schizophrenia. Well-known sources of secondary negative symptoms are psychotic symptoms, disorganisation, anxiety, depression, chronic abuse of illicit drugs and alcohol, an overly high dosage of antipsychotic medication, social deprivation, lack of stimulation and hospitalisation...
August 3, 2017: Drugs
https://www.readbyqxmd.com/read/28772136/glutamatergic-metabolites-among-adolescents-at-risk-for-psychosis
#11
Caroline Demro, Laura Rowland, S Andrea Wijtenburg, James Waltz, James Gold, Emily Kline, Elizabeth Thompson, Gloria Reeves, L Elliot Hong, Jason Schiffman
Proton-Magnetic Resonance Spectroscopy ((1)H-MRS) may serve as an important tool for identifying biomarkers that aid the understanding of early psychosis, as development of this condition may be associated with metabolite concentration changes that reflect an alteration in glutamatergic mechanisms. The current study explored (1)H-MRS metabolite concentrations in the striatum and anterior cingulate cortex (ACC) as potential biomarkers of psychosis-risk symptom severity. In a sample of 12 adolescents at clinical high-risk for psychosis, the subclinical symptom of grandiosity significantly correlated with glutamate in the ACC...
July 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28768599/pre-onset-risk-characteristics-for-mania-among-young-people-at-clinical-high-risk-for-psychosis
#12
Aswin Ratheesh, Susan M Cotton, Christopher G Davey, Ashleigh Lin, Stephen Wood, Hok Pan Yuen, Andreas Bechdolf, Patrick D McGorry, Alison Yung, Michael Berk, Barnaby Nelson
INTRODUCTION: Psychosis and mania share conceptual, genetic and clinical features, which suggest the possibility that they have common antecedents. Participants identified to be at-risk for psychosis might also be at-risk for mania. We aimed to identify the rate and predictors of transition to mania in a cohort of youth with clinical or familial risk for psychosis. METHODS: Among a cohort of 416 young people with an at-risk mental state for psychosis defined using the Ultra-High-Risk (UHR) criteria, 74...
May 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28764561/cpa-guidelines-for-the-pharmacological-treatment-of-schizophrenia-spectrum-and-other-psychotic-disorders-in-children-and-youth
#13
Sabina Abidi, Irfan Mian, Iliana Garcia-Ortega, Tania Lecomte, Thomas Raedler, Kevin Jackson, Kim Jackson, Tamara Pringsheim, Donald Addington
OBJECTIVE: Schizophrenia spectrum and other psychotic disorders often have their onset in adolescence. The sequelae of these illnesses can negatively alter the trajectory of emotional, cognitive, and social development in children and youth if left untreated. Early and appropriate interventions can improve outcomes. This article aims to identify best practices in the pharmacotherapy management of children and youth with schizophrenia spectrum disorders. METHODS: A systematic search was conducted for published guidelines for schizophrenia and schizophrenia spectrum disorders in children and youth (under age 18 years)...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28763503/increased-heterogeneity-of-brain-perfusion-is-an-early-marker-of-central-nervous-system-involvement-in-antiphospholipid-antibody-carriers
#14
Ting-Syuan Lin, Pei-Ying Hsu, Chin-Hao Chang, Chi-Lun Ko, Yu-Min Kuo, Yen-Wen Wu, Ruoh-Fang Yen, Cheng-Han Wu, Ko-Jen Li, Yenh-Chen Hsein, Song-Chou Hsieh
OBJECTIVE: The non-criteria neuropsychiatric manifestations of antiphospholipid syndrome include headache, dizziness, vertigo, seizure, depression and psychosis. There were still no objective methods qualified to detect the early central nervous system involvement in non-criteria antiphospholipid syndrome. We evaluated the effectiveness of Tc-99m ECD SPECT in assessing circulatory insufficiency in the brains of patients with antiphospholipid antibodies and neuropsychiatric symptoms but without thromboembolism...
2017: PloS One
https://www.readbyqxmd.com/read/28760539/dissociable-auditory-mismatch-response-and-connectivity-patterns-in-adolescents-with-schizophrenia-and-adolescents-with-bipolar-disorder-with-psychosis-a-magnetoencephalography-study
#15
Sven Braeutigam, Danai Dima, Sophia Frangou, Anthony James
BACKGROUND: There is overlap between schizophrenia and bipolar disorder regarding genetic risk as well as neuropsychological and structural brain deficits. Finding common and distinct event-response potential (ERP) responses and connectivity patterns may offer potential biomarkers to distinguish the disorders. OBJECTIVE: To examine the neuronal auditory response elicited by a roving mismatch negativity (MMN) paradigm using magnetoencephalography (MEG). PARTICIPANTS: 15 Adolescents with schizophrenia (ASZ), 16 adolescents with bipolar disorder with psychosis (ABP), and 14 typically developing individuals (TD) METHODS: The data were analysed using time-series techniques and dynamic causal modelling (DCM)...
July 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28758344/characterizing-the-inpatient-care-of-young-adults-experiencing-early-psychosis-a-medical-record-review
#16
Joseph H Puyat, Renata Kamieniecki, Brenda Vaughan, Tamara Mihic, Kofi Bonnie, Jeffrey Danielson, Sierra Williams
AIM: To characterize the inpatient care received by individuals experiencing early psychotic episodes in an inner city hospital. METHOD: Medical records of patients admitted between April 01, 2013, and March 31, 2015, to a psychiatric ward at an inner city hospital were retrospectively examined. Included in the study are patients who were 25 years of age or younger and were hospitalized for psychotic symptoms. Demographics and health service use were summarized using descriptive statistics...
July 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28751348/early-intervention-in-psychosis-services
#17
Alice Neale, Dan Kinnair
No abstract text is available yet for this article.
August 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28748485/early-onset-first-episode-psychosis-dimensional-structure-of-symptoms-clinical-subtypes-and-related-neurodevelopmental-markers
#18
Maria Giuseppina Petruzzelli, Lucia Margari, Andrea Bosco, Francesco Craig, Roberto Palumbi, Francesco Margari
Despite the growing interest in a dimensional approach to the assessment of symptoms and clinically relevant phenomena in schizophrenia spectrum disorders, very few studies, to date, have examined the dimensional structure of symptoms in early onset first episode psychosis. In the present study, we assessed a sample of 60 children and adolescents of both sexes with first episode schizophrenia spectrum psychosis. A principal component analysis (PCA) of the Positive and Negative Syndrome Scale (PANSS) was performed and the factors obtained were used to carry out a cluster analysis...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28745387/clinical-and-psychosocial-characterization-of-at-risk-mental-state-and-recent-onset-psychosis-patients-from-an-early-psychosis-program-in-barcelona-spain
#19
Tecelli Domínguez-Martínez, Paula Cristóbal-Narváez, Thomas R Kwapil, Neus Barrantes-Vidal
INTRODUCTION: This study aimed to describe and compare socio-demographic, background, treatment history, and service use, psychopathological and psychosocial characteristics of At-Risk Mental States (ARMS) and First-Episode Psychosis (FEP) patients from the Sant Pere Claver-Early Psychosis Program (SPC-EPP) in Barcelona. METHODS: 43 ARMS-patients and 40 FEP-patients were assessed with several clinical and psychosocial measures at study baseline. RESULTS: Clinical and psychosocial characteristics of the SPC-EPP sample were comparable to those of previous early psychosis studies...
July 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28745307/a-longitudinal-study-of-violent-behavior-in-a-psychosis-risk-cohort
#20
Gary Brucato, Paul S Appelbaum, Jeffrey A Lieberman, Melanie M Wall, Tianshu Feng, Michael D Masucci, Rebecca Altschuler, Ragy R Girgis
There is a lack of insight into the relationships between violent ideation, violent behavior, and early, particularly attenuated, psychosis. Our aims were to examine the relationships between baseline violent behavior and violent ideation and outcome violent behavior and conversion to psychosis in at-risk individuals. We longitudinally assessed 200 individuals at clinical high risk for psychosis for violent ideation and violent behavior using the Structured Interview for Psychosis-Risk Syndromes (SIPS), and rated these according to MacArthur Community Violence categories...
July 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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