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https://www.readbyqxmd.com/read/27895324/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#1
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
No abstract text is available yet for this article.
December 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27636886/mature-and-immature-solid-teratomas-involving-uterine-corpus-cervix-and-ovary
#2
Simona Stolnicu, Emoke Szekely, Calin Molnar, Claudiu V Molnar, Iulia Barsan, Valeria D'Alfonso, Cosmin Moldovan, Gang Zheng, Brigitte M Ronnett, Robert A Soslow
Extragonadal teratomas are rare, and localization in the endometrium and cervix is exceptional, with fewer than 10 case reports documented so far in the English literature. We report here the case of a 46-year-old patient who presented with simultaneous immature teratoma in the endometrium and mature teratomas in the ovary in association with gliomatosis peritonei but with no evidence of gestational origin; she subsequently developed multiple solid mature teratomas in the cervix and parauterine tissue. No other similar cases have been previously reported to our knowledge...
September 15, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27631520/novel-high-grade-endometrial-stromal-sarcoma-a-morphologic-mimicker-of-myxoid-leiomyosarcoma
#3
Lien N Hoang, Amandeep Aneja, Niamh Conlon, Deborah F Delair, Sumit Middha, Ryma Benayed, Martee L Hensley, Kay J Park, Travis J Hollmann, Meera R Hameed, Cristina R Antonescu, Robert A Soslow, Sarah Chiang
Endometrial stromal sarcomas (ESS) are often underpinned by recurrent chromosomal translocations resulting in the fusion of genes involved in epigenetic regulation. To date, only YWHAE-NUTM2 rearrangements are associated with distinctive high-grade morphology and aggressive clinical behavior. We identified 3 ESS morphologically mimicking myxoid leiomyosarcoma of the uterus and sought to describe their unique histopathologic features and identify genetic alterations using next-generation sequencing. All cases displayed predominantly spindled cells associated with abundant myxoid stroma and brisk mitotic activity...
September 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27562491/concurrent-arid1a-and-arid1b-inactivation-in-endometrial-and-ovarian-dedifferentiated-carcinomas
#4
Mackenzie Coatham, Xiaodong Li, Anthony N Karnezis, Lien N Hoang, Basile Tessier-Cloutier, Bo Meng, Robert A Soslow, C Blake Gilks, David G Huntsman, Colin J R Stewart, Lynne M Postovit, Martin Köbel, Cheng-Han Lee
Dedifferentiated carcinoma of the endometrium or the ovary is an aggressive epithelial malignancy that comprises an endometrioid carcinoma together with an undifferentiated carcinoma. We recently reported that inactivation of BRG1 or INI1, core subunits of the switch/sucrose non-fermenting (SWI/SNF) complex, was the likely molecular event underlying dedifferentiation in about half of dedifferentiated carcinomas. In this study, we performed a genomic screen that included other members of the SWI/SNF complex to better delineate the molecular basis in the remainder of these tumours...
August 26, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27544870/evaluation-of-echocardiographic-measures-of-left-ventricular-function-in-patients-with-duchenne-muscular-dystrophy-assessment-of-reproducibility-and-comparison-to-cardiac-magnetic-resonance-imaging
#5
Jonathan H Soslow, Meng Xu, James C Slaughter, Michael Stanley, Kimberly Crum, Larry W Markham, David A Parra
BACKGROUND: Patients with Duchenne muscular dystrophy (DMD) require frequent imaging to assess left ventricular (LV) function. Poor imaging windows can limit the diagnostic utility of echocardiography. Cardiac magnetic resonance imaging (CMR) is the gold standard for the assessment of LV function but has not been universally adopted in patients with DMD. The study objectives were (1) to evaluate the reproducibility of echocardiographic measures of LV function, (2) to evaluate which echocardiographic methods correlate best with CMR LV ejection fraction (LVEF), and (3) to evaluate whether CMR provides additional value compared with echocardiography...
October 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27526294/the-2015-fred-waldorf-stewart-award-recipient-robert-h-young-md
#6
Robert A Soslow, Edi Brogi
No abstract text is available yet for this article.
August 11, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27491810/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#7
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly aggressive subtypes of uterine cancer, not well characterized at a molecular level. To investigate whether dedifferentiated carcinomas carry molecular genetic alterations similar to those of pure undifferentiated carcinomas, and to gain insight into the pathogenesis of these tumors, we selected a cohort of 18 undifferentiated endometrial carcinomas, 8 of them with a well-differentiated endometrioid carcinoma component (dedifferentiated endometrioid carcinomas), and studied them by immunohistochemistry and massive parallel and Sanger sequencing...
August 5, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27421752/molecular-classification-of-endometrial-carcinoma-on-diagnostic-specimens-is-highly-concordant-with-final-hysterectomy-earlier-prognostic-information-to-guide-treatment
#8
Aline Talhouk, Lien N Hoang, Melissa K McConechy, Quentin Nakonechny, Joyce Leo, Angela Cheng, Samuel Leung, Winnie Yang, Amy Lum, Martin Köbel, Cheng-Han Lee, Robert A Soslow, David G Huntsman, C Blake Gilks, Jessica N McAlpine
OBJECTIVE: Categorization and risk stratification of endometrial carcinomas is inadequate; histomorphologic assessment shows considerable interobserver variability, and risk of metastases and recurrence can only be derived after surgical staging. We have developed a Proactive Molecular Risk classification tool for Endometrial cancers (ProMisE) that identifies four distinct prognostic subgroups. Our objective was to assess whether molecular classification could be performed on diagnostic endometrial specimens obtained prior to surgical staging and its concordance with molecular classification performed on the subsequent hysterectomy specimen...
October 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27367496/uterine-cancer-after-risk-reducing-salpingo-oophorectomy-without-hysterectomy-in-women-with-brca-mutations
#9
Catherine A Shu, Malcolm C Pike, Anjali R Jotwani, Tara M Friebel, Robert A Soslow, Douglas A Levine, Katherine L Nathanson, Jason A Konner, Angela G Arnold, Faina Bogomolniy, Fanny Dao, Narciso Olvera, Elizabeth K Bancroft, Deborah J Goldfrank, Zsofia K Stadler, Mark E Robson, Carol L Brown, Mario M Leitao, Nadeem R Abu-Rustum, Carol A Aghajanian, Joanne L Blum, Susan L Neuhausen, Judy E Garber, Mary B Daly, Claudine Isaacs, Rosalind A Eeles, Patricia A Ganz, Richard R Barakat, Kenneth Offit, Susan M Domchek, Timothy R Rebbeck, Noah D Kauff
Importance: The link between BRCA mutations and uterine cancer is unclear. Therefore, although risk-reducing salpingo-oophorectomy (RRSO) is standard treatment among women with BRCA mutations (BRCA+ women), the role of concomitant hysterectomy is controversial. Objective: To determine the risk for uterine cancer and distribution of specific histologic subtypes in BRCA+ women after RRSO without hysterectomy. Design, Setting, and Participants: This multicenter prospective cohort study included 1083 women with a deleterious BRCA1 or BRCA2 mutation identified from January 1, 1995, to December 31, 2011, at 9 academic medical centers in the United States and the United Kingdom who underwent RRSO without a prior or concomitant hysterectomy...
June 30, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27241108/gynecologic-manifestations-of-less-commonly-encountered-hereditary-syndromes
#10
REVIEW
Deborah F DeLair, Robert A Soslow
This review covers gynecologic manifestations that may occur in rare hereditary syndromes. Recent advances in disorders, such as hereditary leiomyomatosis, renal cell carcinoma syndrome and tuberous sclerosis complex, are discussed as well as lesions that occur in von Hippel-Lindau syndrome, nevoid basal cell carcinoma syndrome, Cowden syndrome, Ollier disease/Maffucci syndrome, and Carney complex. Characteristic clinicopathologic features of each of these syndromes are discussed with an emphasis on the key features that enable pathologists to identify patients at highest risk for these diseases...
June 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27182492/the-correlation-of-skeletal-and-cardiac-muscle-dysfunction-in-duchenne-muscular-dystrophy
#11
Andrew D Posner, Jonathan H Soslow, W Bryan Burnette, Aihua Bian, Ayumi Shintani, Douglas B Sawyer, Larry W Markham
BACKGROUND: Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle and cardiac dysfunction. While skeletal muscle dysfunction precedes cardiomyopathy, the relationship between the progressive decline in skeletal and cardiac muscle function is unclear. This relationship is especially important given that the myocardial effects of many developing DMD therapies are largely unknown. OBJECTIVE: Our objective was to assess the relationship between progression of skeletal muscle weakness and onset of cardiac dysfunction in DMD...
2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27139150/interobserver-variability-in-the-diagnosis-of-uterine-high-grade-endometrioid-carcinoma
#12
Sumi Thomas, Yaser Hussein, Sudeshna Bandyopadhyay, Michele Cote, Oudai Hassan, Eman Abdulfatah, Baraa Alosh, Hui Guan, Robert A Soslow, Rouba Ali-Fehmi
CONTEXT: -Low interobserver diagnostic agreement exists among high-grade endometrial carcinomas. OBJECTIVE: -To evaluate diagnostic variability in International Federation of Gynecology and Obstetrics (FIGO) grade 3 endometrioid adenocarcinoma (G3EC) in 2 different sign-out practices. DESIGN: -Sixty-six G3EC cases were identified from pathology archives of Wayne State University (WSU, Detroit, Michigan) (general surgical pathology sign-out) and 65 from Memorial Sloan Kettering Cancer Center (MSK, New York, New York) (gynecologic pathology focused sign-out)...
August 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27113549/squamous-precursor-lesions-of-the-vulva-current-classification-and-diagnostic-challenges
#13
REVIEW
Lien N Hoang, Kay J Park, Robert A Soslow, Rajmohan Murali
Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. In contrast, VIN of differentiated type (dVIN) occurs in post-menopausal women and develops independent of HPV infection...
June 2016: Pathology
https://www.readbyqxmd.com/read/27112632/a-pilot-study-of-topical-imiquimod-therapy-for-the-treatment-of-recurrent-extramammary-paget-s-disease
#14
Renee A Cowan, Destin R Black, Lien N Hoang, Kay J Park, Robert A Soslow, Floor J Backes, Ginger J Gardner, Nadeem R Abu-Rustum, Mario M Leitao, Eric L Eisenhauer, Dennis S Chi
OBJECTIVE: The objective of this prospective pilot study was to assess the clinical and histologic effects of topical imiquimod therapy on recurrent extramammary Paget's disease of the vulva. METHODS: Patients with biopsy-proven recurrent extramammary Paget's disease presenting to the gynecology outpatient services at two participating institutions were recruited for conservative treatment with 5% imiquimod cream from 2007 to 2011. The topical cream was to be applied 3 times per week for 12weeks...
July 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27101785/immunophenotypic-features-of-dedifferentiated-endometrial-carcinoma-insights-from-brg1-ini1-deficient-tumours
#15
Lien N Hoang, Yow-Shan Lee, Anthony N Karnezis, Basile Tessier-Cloutier, Noorah Almandani, Mackenzie Coatham, C Blake Gilks, Robert A Soslow, Colin J R Stewart, Martin Köbel, Cheng-Han Lee
AIMS: Dedifferentiated endometrial carcinoma (DDEC) is defined by the presence of an undifferentiated carcinoma together with an endometrioid carcinoma. Inactivation of SMARCA4 (BRG1) and inactivation of SMARCB1 (INI1) were recently described as potential mechanisms underlying the histological dedifferentiation. The aim of this study was to characterize the immunophenotypic features of DDECs, particularly in cases with prototypical histological and molecular features (BRG1/INI1 deficiency)...
October 2016: Histopathology
https://www.readbyqxmd.com/read/26905542/impact-of-obesity-on-sentinel-lymph-node-mapping-in-patients-with-newly-diagnosed-uterine-cancer-undergoing-robotic-surgery
#16
Ane Gerda Zahl Eriksson, Margaret Montovano, Anna Beavis, Robert A Soslow, Qin Zhou, Nadeem R Abu-Rustum, Ginger J Gardner, Oliver Zivanovic, Richard R Barakat, Carol L Brown, Douglas A Levine, Yukio Sonoda, Mario M Leitao, Elizabeth L Jewell
PURPOSE: The aim of this study was to determine the impact of obesity on the rate of successful sentinel lymph node (SLN) mapping in patients with uterine cancer undergoing robotic surgery, and compare SLN detection rates using indocyanine green (ICG) versus blue dye. METHODS: We reviewed robotic cases undergoing SLN mapping with a cervical injection from January 2011 to December 2013 using either blue dye or ICG with near-infrared (NIR) fluorescence imaging. Data were stratified by body mass index (BMI) and the dye used...
August 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/26832770/massively-parallel-sequencing-based-clonality-analysis-of-synchronous-endometrioid-endometrial-and-ovarian-carcinomas
#17
Anne M Schultheis, Charlotte K Y Ng, Maria R De Filippo, Salvatore Piscuoglio, Gabriel S Macedo, Sonia Gatius, Belen Perez Mies, Robert A Soslow, Raymond S Lim, Agnes Viale, Kety H Huberman, Jose C Palacios, Jorge S Reis-Filho, Xavier Matias-Guiu, Britta Weigelt
Synchronous early-stage endometrioid endometrial carcinomas (EECs) and endometrioid ovarian carcinomas (EOCs) are associated with a favorable prognosis and have been suggested to represent independent primary tumors rather than metastatic disease. We subjected sporadic synchronous EECs/EOCs from five patients to whole-exome massively parallel sequencing, which revealed that the EEC and EOC of each case displayed strikingly similar repertoires of somatic mutations and gene copy number alterations. Despite the presence of mutations restricted to the EEC or EOC in each case, we observed that the mutational processes that shaped their respective genomes were consistent...
June 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26795569/increased-myocardial-native-t1-and-extracellular-volume-in-patients-with-duchenne-muscular-dystrophy
#18
Jonathan H Soslow, Stephen M Damon, Kimberly Crum, Mark A Lawson, James C Slaughter, Meng Xu, Andrew E Arai, Douglas B Sawyer, David A Parra, Bruce M Damon, Larry W Markham
BACKGROUND: Duchenne muscular dystrophy (DMD) cardiomyopathy is a progressive disease for which there is no cure. Disease-specific therapies are needed that can be initiated before irreversible myocardial damage ensues. In order to evaluate therapeutic efficacy, surrogate endpoints other than ejection fraction must be found. The hypothesis of this study is that T1 and extracellular volume fraction (ECV) mapping using cardiovascular magnetic resonance (CMR) can detect diffuse extracellular matrix expansion in DMD patients with normal left ventricular ejection fraction (LVEF) and without myocardial late gadolinium enhancement (LGE)...
January 21, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/26793759/letter-to-the-editor-regarding-the-manuscript-entitled-prevalence-of-occult-gynecologic-malignancy-at-the-time-of-risk-reducing-and-nonprophylactic-surgery-in-patients-with-lynch-syndrome-by-lachiewicz-et-al-gynecol-oncol-2014-132-434-437
#19
https://www.readbyqxmd.com/read/26715174/practical-issues-related-to-uterine-pathology-staging-frozen-section-artifacts-and-lynch-syndrome
#20
REVIEW
Robert A Soslow
This review covers three areas in endometrial tumor pathology: International Federation of Gynecology and Obstetrics (FIGO) staging, the use of frozen section, and Lynch syndrome. The section on FIGO staging will emphasize problems that practicing pathologists often confront, such as measuring the depth of myometrial invasion, assessing for the presence of cervical stromal invasion, detecting low-volume lymph node metastases, and recognizing synchronous endometrial and ovarian tumors and artifacts. The frozen section portion of this review will focus on the performance characteristics of intraoperative examination of the uterus to determine tumor grade and depth of myometrial invasion, including suggestions for alternative methods...
January 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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