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REVIEW
Holger Moch, Mahul B Amin, Daniel M Berney, Eva M Compérat, Anthony J Gill, Arndt Hartmann, Santosh Menon, Maria R Raspollini, Mark A Rubin, John R Srigley, Puay Hoon Tan, Satish K Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ian Cree, George J Netto
The fifth edition of the World Health Organization (WHO) classification of urogenital tumours (WHO "Blue Book"), published in 2022, contains significant revisions. This review summarises the most relevant changes for renal, penile, and testicular tumours. In keeping with other volumes in the fifth edition series, the WHO classification of urogenital tumours follows a hierarchical classification and lists tumours by site, category, family, and type. The section "essential and desirable diagnostic criteria" included in the WHO fifth edition represents morphologic diagnostic criteria, combined with immunohistochemistry and relevant molecular tests...
November 2022: European Urology
#22
JOURNAL ARTICLE
Anuradha Gopalan, Hikmat Al-Ahmadie, Ying-Bei Chen, Judy Sarungbam, S Joseph Sirintrapun, Satish K Tickoo, Victor E Reuter, Samson W Fine
AIM: Clinicopathologic characterisation of a contemporary series of neuroendocrine (NE) differentiation in the setting of prostatic carcinoma (PCa) was examined. METHODS AND RESULTS: We reviewed institutional databases for in-house cases with a history of PCa and histopathologic evidence of NE differentiation during the disease course. In all, 79 cases were identified: 32 primary and 47 metastases. Metastatic lesions were in liver (n = 15), lymph node (n = 9), bone (n = 6), lung (n = 3), brain (n = 1), and other sites (n = 13)...
August 2022: Histopathology
#23
JOURNAL ARTICLE
Nima Almassi, Karissa Whiting, Antoun Toubaji, Andrew T Lenis, Emmet J Jordan, Helen Won, Ashley M Regazzi, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Satish K Tickoo, Irina Ostrovnaya, Eugene J Pietzak, Eugene K Cha, Alvin C Goh, Timothy F Donahue, Harry W Herr, S Machele Donat, Guido Dalbagni, Bernard H Bochner, Min Yuen Teo, Samuel A Funt, Jonathan E Rosenberg, Victor E Reuter, Dean F Bajorin, David B Solit, Hikmat Al-Ahmadie, Gopa Iyer
PURPOSE: To compare oncologic outcomes and genomic alteration profiles in patients with bladder and urachal adenocarcinoma, urothelial carcinoma (UC) with glandular differentiation, and UC, not otherwise specified (NOS) undergoing surgical resection, with emphasis on response to systemic therapy. METHODS: We identified patients with bladder cancer with glandular variants who underwent surgical resection at Memorial Sloan Kettering from 1995 to 2018 (surgical cohort) and/or patients who had tumor sequencing using a targeted next-generation sequencing platform (genomics cohort)...
June 2022: JCO Precision Oncology
#24
JOURNAL ARTICLE
Sandeep Budhiraja, Bansidhar Tarai, Dinesh Jain, Mona Aggarwal, Abhaya Indrayan, Poonam Das, Ram Shankar Mishra, Supriya Bali, Monica Mahajan, Jay Kirtani, Rommel Tickoo, Pankaj Soni, Vivek Nangia, Ajay Lall, Nevin Kishore, Ashish Jain, Omender Singh, Namrita Singh, Ashok Kumar, Prashant Saxena, Arun Dewan, Ritesh Aggarwal, Mukesh Mehra, Meenakshi Jain, Vimal Nakra, Bhagwan Das Sharma, Praveen Kumar Pandey, Yogendra Pal Singh, Vijay Arora, Suchitra Jain, Ranjana Chhabra, Preeti Tuli, Vandana Boobna, Alok Joshi, Manoj Aggarwal, Rajiv Gupta, Pankaj Aneja, Sanjay Dhall, Vineet Arora, Inder Mohan Chugh, Sandeep Garg, Vikas Mittal, Ajay Gupta, Bikram Jyoti, Puneet Sharma, Pooja Bhasin, Shakti Jain, Rajinder Kumar Singhal, Atul Bhasin, Anil Vardani, Vivek Pal, Deepak Gargi Pande, Tribhuvan Gulati, Sandeep Nayar, Sunny Kalra, Manish Garg, Rajesh Pande, Pradyut Bag, Arpit Gupta, Jitin Sharma, Anil Handoo, Purabi Burman, Ajay Kumar Gupta, Pankaj Nand Choudhary, Ashish Gupta, Puneet Gupta, Sharad Joshi, Nitesh Tayal, Manish Gupta, Anita Khanna, Sachin Kishore, Shailesh Sahay, Rajiv Dang, Neelima Mishra, Sunil Sekhri, Rajneesh Chandra Srivastava, Mitali Bharat Agrawal, Mohit Mathur, Akash Banwari, Sumit Khetarpal, Sachin Pandove, Deepak Bhasin, Harpal Singh, Devender Midha, Anjali Bhutani, Manpreet Kaur, Amarjit Singh, Shalini Sharma, Komal Singla, Pooja Gupta, Vinay Sagar, Ambrish Dixit, Rashmi Bajpai, Vaibhav Chachra, Puneet Tyagi, Sanjay Saxena, Bhupesh Uniyal, Shantanu Belwal, Imliwati Aier, Mini Singhal, Ankit Khaduri
Objective: To gain better insight into the extent of secondary bacterial and fungal infections in hospitalized patients in India, and to assess how these alter the course of coronavirus disease 2019 (COVID-19) so that control measures can be suggested. Methods: In this retrospective, multicentre study, the data of all patients who tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reverse transcriptase polymerase chain reaction (RT-PCR), admitted to hospital between March 2020 and July 2021, were accessed from the electronic health records of a network of 10 hospitals across five states in North India...
June 2022: IJID Reg
#25
JOURNAL ARTICLE
Min Yuen Teo, Brendan J Guercio, Arshi Arora, Xueli Hao, Ashley M Regazzi, Timothy Donahue, Harry W Herr, Alvin C Goh, Eugene K Cha, Eugene Pietzak, Sherri M Donat, Guido Dalbagni, Bernard H Bochner, Semra Olgac, Judy Sarungbam, S Joseph Sirintrapun, Ying-Bei Chen, Anuradha Gopalan, Samson W Fine, Satish K Tickoo, Victor E Reuter, Britta Weigelt, Anne M Schultheis, Samuel A Funt, Dean F Bajorin, David B Solit, Gopa Iyer, Irina Ostrovnaya, Jonathan E Rosenberg, Hikmat Al-Ahmadie
INTRODUCTION: Small cell carcinoma of the bladder (SCCB) is a rare variant of bladder cancer with poor outcomes. We evaluated long-term outcomes of nonmetastatic (M0) and metastatic (M1) SCCB and correlated pathologic response with genomic alterations of patients treated with neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: Clinical history and pathology samples from SCCB patients diagnosed at our institution were reviewed. RESULTS: One hundred and ninety-nine SCCB patients were identified...
May 11, 2022: Clinical Genitourinary Cancer
#26
REVIEW
João Lobo, Riuko Ohashi, Mahul B Amin, Daniel M Berney, Eva M Compérat, Ian A Cree, Anthony J Gill, Arndt Hartmann, Santosh Menon, George J Netto, Maria R Raspollini, Mark A Rubin, Puay Hoon Tan, Satish K Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ming Zhou, John R Srigley, Holger Moch
The 5th edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems contains relevant revisions and introduces a group of molecularly defined renal tumour subtypes. Herein we present the World Health Organization (WHO) 2022 perspectives on papillary and chromophobe renal cell carcinoma with emphasis on their evolving classification, differential diagnosis, and emerging entities. The WHO 2022 classification eliminated the type 1/2 papillary renal cell carcinoma (pRCC) subcategorization, given the recognition of frequent mixed tumour phenotypes and the existence of entities with a different molecular background within the type 2 pRCC category...
October 2022: Histopathology
#27
REVIEW
Daniel M Berney, Ian Cree, Vishal Rao, Holger Moch, John R Srigley, Toyonori Tsuzuki, Mahul B Amin, Eva M Comperat, Arndt Hartmann, Santosh Menon, George J Netto, Mark A Rubin, Samra Turajlic, Maria R Raspollini, Satish K Tickoo
The 5th edition of the World Health Organisation Blue Book was published recently and includes a comprehensive update on testicular tumours. This builds upon the work of the 4th edition, retaining its structure and main nomenclature, including the use of the term 'germ cell neoplasia in situ' (GCNIS) for the pre-invasive lesion of most germ cell tumours and division from those not derived from GCNIS. While there have been important developments in understanding the molecular underpinnings of testicular cancer, this updated classification paradigm and approach remains rooted in morphology...
October 2022: Histopathology
#28
JOURNAL ARTICLE
Bin Xu, Jie-Fu Chen, Judy Sarungbam, Satish Tickoo, Brendan C Dickson, Victor E Reuter, Cristina R Antonescu
Tumors with NUTM1 fusions occur predominantly in the thoracic cavity and head and neck region. However, recent literature expanded the location of NUTM1-translocated malignancy to soft tissue, brain, and visceral organs. In this study, we describe the first series of six NUTM1-translocated carcinomas and sarcomas occurring in the genitourinary tract. The sites of origin were kidney (n = 2), bladder (n = 3), and penis (n = 1). All tumors occurred in adulthood (range: 30-78 years)...
September 2022: Genes, Chromosomes & Cancer
#29
Seyed Mohammad Nahidi, Harman Singh, Sharang Tickoo, Leonidha Duka, Jung Won, Jennifer Gulas
Mycobacterium tuberculosis is primarily known to affect the lungs with cavitary lesions and enlarged lymph nodes as the first telltale sign. However, if the bacteria spread to extrapulmonary areas such as the bones, and lack lymphadenopathy, then the differential diagnosis may become misleading. We present a case of a 68-year-old male patient with a chief complaint of chronic left hip pain upon which computer tomography identified lytic lesions on the left hip. Given the mildly elevated prostate-specific antigen with a family history of prostate cancer, a bone biopsy was warranted...
February 2022: Journal of Medical Cases
#30
Min Yuen Teo, Hikmat Al-Ahmadie, Kenneth Seier, Christopher Tully, Ashley M Regazzi, Eugene Pietzak, David B Solit, Satish Tickoo, Victor Reuter, Eugene K Cha, Harry Herr, Timothy Donahue, Sherri M Donat, Guido Dalbagni, Bernard H Bochner, Samuel Funt, Gopakumar V Iyer, Dean F Bajorin, Irina Ostrovnaya, Jonathan E Rosenberg
No abstract text is available yet for this article.
May 2022: British Journal of Cancer
#31
JOURNAL ARTICLE
Paari Murugan, Liwei Jia, Renzo G Dinatale, Melissa Assel, Nicole Benfante, Hikmat A Al-Ahmadie, Samson W Fine, Anuradha Gopalan, Judy Sarungbam, S Joseph Sirintrapun, A Ari Hakimi, Paul Russo, Ying-Bei Chen, Satish K Tickoo, Victor E Reuter
The morphologic spectrum of type 1 papillary renal cell carcinoma (PRCC) is not well-defined, since a significant proportion of cases have mixed type 1 and 2 histology. We analyzed 199 cases of PRCC with any (even if focal) type 1 features, with a median follow-up of 12 years, to identify clinicopathological features associated with outcome. Ninety-five tumors (48%) of the cohort contained some type 2 component (median amount: 25%; IQR: 10%, 70%). As a group they showed high rates of progression-free (PFS) and cancer-specific survival (CSS)...
June 2022: Modern Pathology
#32
JOURNAL ARTICLE
Amit Bardia, Miriam M Treggiari, George Michel, Feng Dai, Mayanka Tickoo, Mabel Wai, Kevin Schuster, Michael Mathis, Nirav Shah, Sachin Kheterpal, Robert B Schonberger
Importance: Despite widespread adherence to Surgical Care Improvement Project antibiotic measures, prevention of surgical site infections (SSIs) remains a clinical challenge. Several components of perioperative antibiotic prophylaxis guidelines are incompletely monitored and reported within the Surgical Care Improvement Project program. Objectives: To describe adherence to each component of perioperative antibiotic prophylaxis guidelines in regard to procedure-specific antibiotic choice, weight-adjusted dosing, and timing of first and subsequent administrations in a nationwide, multicenter cohort of patients undergoing noncardiac surgery...
December 1, 2021: JAMA Network Open
#33
Shannon Caesar-Peterson, Dosuk Yoon, Katrina Tulla, Seyed M Nahidi, Sharang Tickoo, Mudnia Sheikh, Hector Depaz
Kikuchi-Fujimoto disease (KFD) is a rare lymphohistiocytic disorder with an unknown etiopathogenesis. Due to its non-specific lymphadenopathy presentation, treatment is complicated by the frequency by which it is misdiagnosed-for example up to one-third of cases are misdiagnosed as malignant lymphoma, leading to expensive clinical testing and overtreatment of this typically self-limiting illness. KFD has a strong association with SLE, although its transience and rarity make it difficult to investigate. We present a case of KFD to illustrate the variance in presentation and typical outcome of KFD...
October 2021: Journal of Surgical Case Reports
#34
REVIEW
Andrew Notarianni, Mayanka Tickoo, Amit Bardia
PURPOSE OF REVIEW: Owing to increased utilization of Mechanical Circulatory Support (MCS) devices, patients with these devices frequently present for surgeries requiring anesthetic support. The current article provides basics of perioperative management of these devices. RECENT FINDINGS: Use of extracorporeal membrane oxygenation (ECMO) and left ventricular assist devices (LVADs) are on the rise with recently updated management guidelines. Veno-venous ECMO utilization has been widely utilized as a salvage therapy during the COVID-19 pandemic...
2021: Current Anesthesiology Reports
#35
JOURNAL ARTICLE
Sounak Gupta, Helen Won, Kalyani Chadalavada, Gouri J Nanjangud, Ying-Bei Chen, Hikmat A Al-Ahmadie, Samson W Fine, Sahussapont J Sirintrapun, Vivian E Strong, Nitya Raj, Diane Reidy Lagunes, Chad M Vanderbilt, Michael F Berger, Marc Ladanyi, Snjezana Dogan, Satish K Tickoo, Victor E Reuter, Anuradha Gopalan
Molecular characterization of adrenocortical carcinomas (ACC) by The Cancer Genome Atlas (TCGA) has highlighted a high prevalence of TERT alterations, which are associated with disease progression. Herein, 78 ACC were profiled using a combination of next generation sequencing (n = 76) and FISH (n = 9) to assess for TERT alterations. This data was combined with TCGA dataset (n = 91). A subset of borderline adrenocortical tumors (n = 5) and adrenocortical adenomas (n = 7) were also evaluated...
September 22, 2021: Endocrine Pathology
#36
JOURNAL ARTICLE
Arianna Baggiolini, Scott J Callahan, Emily Montal, Joshua M Weiss, Tuan Trieu, Mohita M Tagore, Sam E Tischfield, Ryan M Walsh, Shruthy Suresh, Yujie Fan, Nathaniel R Campbell, Sarah C Perlee, Nathalie Saurat, Miranda V Hunter, Theresa Simon-Vermot, Ting-Hsiang Huang, Yilun Ma, Travis Hollmann, Satish K Tickoo, Barry S Taylor, Ekta Khurana, Richard P Koche, Lorenz Studer, Richard M White
Oncogenes only transform cells under certain cellular contexts, a phenomenon called oncogenic competence. Using a combination of a human pluripotent stem cell–derived cancer model along with zebrafish transgenesis, we demonstrate that the transforming ability of BRAFV600E along with additional mutations depends on the intrinsic transcriptional program present in the cell of origin. In both systems, melanocytes are less responsive to mutations, whereas both neural crest and melanoblast populations are readily transformed...
September 3, 2021: Science
#37
JOURNAL ARTICLE
Seyed Mohammad Nahidi, Khuram Khan, Christopher Engler, Sharang Tickoo, Carina Biggs
INTRODUCTION: Hundreds of thousands of cholecystectomies and appendectomies are performed in the United States annually. Due to the prevalence of cholecystitis and appendicitis, a subset of patients will require both operations. The limited literature describing these patients supports a laparoscopic approach over open surgery; consistent with the advantages of laparotomy over open surgery in the treatment of each condition individually. CASE PRESENTATION: We report two cases where a patient presented with cholecystitis and appendicitis simultaneously...
September 2021: International Journal of Surgery Case Reports
#38
JOURNAL ARTICLE
Shawn Dason, Emily A Vertosick, Kazuma Udo, Daniel D Sjoberg, Andrew J Vickers, Hikmat Al-Ahmadie, Ying-Bei Chen, Anuradha Gopalan, S Joseph Sirintrapun, Satish K Tickoo, Peter T Scardino, James A Eastham, Victor E Reuter, Samson W Fine
OBJECTIVE: To determine whether subclassification of positive surgical margins (PSMs) increases predictive ability for biochemical recurrence (BCR) and aids clinical decision-making in patients undergoing radical prostatectomy. PATIENTS AND METHODS: We studied 2147 patients with pT2 and pT3a prostate cancer with detailed surgical margin parameters and BCR status. We compared a base model, a linear predictor calculated from the Memorial Sloan Kettering Cancer Center postoperative nomogram (prostate-specific antigen, pathological tumour grade and stage), with the addition of surgical margin status to five additional models (base model plus surgical margin subclassifications) to evaluate enhancement in predictive accuracy...
February 2022: BJU International
#39
JOURNAL ARTICLE
Xiao-Ming Wang, Yuping Zhang, Rahul Mannan, Stephanie L Skala, Roshni Rangaswamy, Anya Chinnaiyan, Fengyun Su, Xuhong Cao, Sylvia Zelenka-Wang, Lisa McMurry, Hong Xiao, Daniel E Spratt, Ankur R Sangoi, Lina Shao, Bryan L Betz, Noah Brown, Satish K Tickoo, Jesse K McKenney, Pedram Argani, Sounak Gupta, Victor E Reuter, Arul M Chinnaiyan, Saravana M Dhanasekaran, Rohit Mehra
Microphthalmia-associated transcription factor (MiT) family aberration-associated renal cell carcinoma (MiTF-RCC) is a subtype of renal cell carcinoma harboring recurrent chromosomal rearrangements involving TFE3 or TFEB genes. MiTF-RCC is morphologically diverse, can histologically resemble common RCC subtypes like clear cell RCC and papillary RCC, and often poses a diagnostic challenge in genitourinary clinical and pathology practice. To characterize the MiTF-RCC at the molecular level and identify biomarker signatures associated with MiTF-RCC, we analyzed RNAseq data from MiTF-RCC, other RCC subtypes and benign kidney...
August 2021: Modern Pathology
#40
Kiril Trpkov, Sean R Williamson, Anthony J Gill, Adebowale J Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I Epstein, John C Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B Gordetsky, Sounak Gupta, Huiying He, Michelle S Hirsch, Peter A Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K McKenney, Rohit Mehra, Santosh Menon, George J Netto, Christopher G Przybycin, Priya Rao, Qiu Rao, Victor E Reuter, Rola M Saleeb, Rajal B Shah, Steven C Smith, Satish Tickoo, Maria S Tretiakova, Lawrence True, Virginie Verkarre, Sara E Wobker, Ming Zhou, Ondrej Hes
No abstract text is available yet for this article.
May 2021: Modern Pathology
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