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https://www.readbyqxmd.com/read/29234989/clinical-cardiovascular-genetic-counselors-take-a-leading-role-in-team-based-variant-classification
#1
Chloe Reuter, Megan E Grove, Kate Orland, Katherine Spoonamore, Colleen Caleshu
We sought to delineate the genetic test review and interpretation practices of clinical cardiovascular genetic counselors. A one-time anonymous online survey was taken by 46 clinical cardiovascular genetic counselors recruited through the National Society of Genetic Counselors Cardiovascular Special Interest Group. Nearly all (95.7%) gather additional information on variants reported on clinical genetic test reports and most (81.4%) assess the classification of such variants. Clinical cardiovascular genetic counselors typically (81...
December 12, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29232126/alkali-and-alkaline-earth-metal-derivatives-of-disila-bridged-podands-coordination-chemistry-and-structural-diversity
#2
Fabian Dankert, Carsten Donsbach, Christopher-Nils Mais, Kirsten Reuter, Carsten von Hänisch
Within this study, the synthesis and coordination chemistry of open-chain ligands bearing disila-units is presented. Instead of basic 1:1 complexes, structural diversity was discovered in the variety of ligand and salt. Stable complexes of alkali and alkaline earth metal complexes were obtained by equimolar reactions of different salts with the disila-bridged podands 8,9-disila-EO5 (1) and 11,12-disila-EO7 (2) (EO5 = pentaethylene glycol; EO7 = heptaethylene glycol). The respective alkaline earth metal complexes of the type [Ca(8,9-disila-EO5)(OTf)2] (3), [Sr(8,9-disila-EO5)I2] (5), [Sr(11,12-disila-EO7)I]I (6), and [Ba(11,12-disila-EO7)OTf2] (7) (OTf = CF3SO3-) were characterized via single-crystal X-ray diffraction analyses...
December 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29223193/quality-indicators-for-evaluating-prehospital-emergency-care-a-scoping-review
#3
Ian Howard, Peter Cameron, Lee Wallis, Maaret Castren, Veronica Lindstrom
Introduction Historically, the quality and performance of prehospital emergency care (PEC) has been assessed largely based on surrogate, non-clinical endpoints such as response time intervals or other crude measures of care (eg, stakeholder satisfaction). However, advances in Emergency Medical Services (EMS) systems and services world-wide have seen their scope and reach continue to expand. This has dictated that novel measures of performance be implemented to compliment this growth. Significant progress has been made in this area, largely in the form of the development of evidence-informed quality indicators (QIs) of PEC...
December 10, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29222818/task-related-effective-connectivity-reveals-that-the-cortical-rich-club-gates-cortex-wide-communication
#4
Mario Senden, Niels Reuter, Martijn P van den Heuvel, Rainer Goebel, Gustavo Deco, Matthieu Gilson
Higher cognition may require the globally coordinated integration of specialized brain regions into functional networks. A collection of structural cortical hubs-referred to as the rich club-has been hypothesized to support task-specific functional integration. In the present paper, we use a whole-cortex model to estimate directed interactions between 68 cortical regions from functional magnetic resonance imaging activity for four different tasks (reflecting different cognitive domains) and resting state. We analyze the state-dependent input and output effective connectivity (EC) of the structural rich club and relate these to whole-cortex dynamics and network reconfigurations...
December 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29221636/urothelial-neoplasms-in-pediatric-and-young-adult-patients-a-large-single-center-series
#5
James A Saltsman, Marcus M Malek, Victor E Reuter, William J Hammond, Enrico Danzer, Harry W Herr, Michael P LaQuaglia
PURPOSE: Bladder cancer is the sixth most common cancer in the United States, but is exceedingly rare in young patients, leading to a lack of accepted standards for diagnosis, treatment, and surveillance. We review our institutional experience with bladder urothelial neoplasms in pediatric and young adult patients summarizing presentation, treatment, and outcomes. METHODS: Surgical pathology records at our institution were searched for cases of urothelial neoplasms among patients ≤25 years of age treated between January 1997 and September 2016...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29219593/first-dark-matter-search-results-from-the-xenon1t-experiment
#6
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, R Gardner, C Geis, L W Goetzke, L Grandi, Z Greene, C Grignon, C Hasterok, E Hogenbirk, J Howlett, R Itay, B Kaminsky, S Kazama, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, F Lombardi, J A M Lopes, A Manfredini, I Mariş, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, A Molinario, K Morå, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, B Riedel, A Rizzo, S Rosendahl, N Rupp, R Saldanha, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, E Shockley, M Silva, H Simgen, M V Sivers, A Stein, S Thapa, D Thers, A Tiseni, G Trinchero, C Tunnell, M Vargas, N Upole, H Wang, Z Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang, T Zhu
We report the first dark matter search results from XENON1T, a ∼2000-kg-target-mass dual-phase (liquid-gas) xenon time projection chamber in operation at the Laboratori Nazionali del Gran Sasso in Italy and the first ton-scale detector of this kind. The blinded search used 34.2 live days of data acquired between November 2016 and January 2017. Inside the (1042±12)-kg fiducial mass and in the [5,40]  keV_{nr} energy range of interest for weakly interacting massive particle (WIMP) dark matter searches, the electronic recoil background was (1...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29219436/nonadiabatic-vibrational-damping-of-molecular-adsorbates-insights-into-electronic-friction-and-the-role-of-electronic-coherence
#7
Simon P Rittmeyer, Jörg Meyer, Karsten Reuter
We present a perturbation approach rooted in time-dependent density-functional theory to calculate electron-hole (e-h) pair excitation spectra during the nonadiabatic vibrational damping of adsorbates on metal surfaces. Our analysis for the benchmark systems CO on Cu(100) and Pt(111) elucidates the surprisingly strong influence of rather short electronic coherence times. We demonstrate how in the limit of short electronic coherence times, as implicitly assumed in prevalent quantum nuclear theories for the vibrational lifetimes as well as electronic friction, band structure effects are washed out...
October 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29217100/childhood-corporal-punishment-and-future-perpetration-of-physical-dating-violence
#8
Jeff R Temple, Hye Jeong Choi, Tyson Reuter, David Wolfe, Catherine A Taylor, Sheri Madigan, Lauren E Scott
OBJECTIVE: To test whether experiencing childhood corporal punishment is linked to later perpetration of dating violence. STUDY DESIGN: Young adults (n = 758; 61% female; mean age of 20 years), originally recruited for a longitudinal study as 9th- and 10th-grade Texas high school students, were asked about their childhood experiences with corporal punishment and physical abuse, as well as current experiences with dating violence. A path model was used to determine whether childhood corporal punishment was related to recent perpetration of physical dating violence, while controlling for childhood physical abuse, age, sex, ethnicity, and socioeconomic status...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29215973/dissipation-of-antimicrobial-resistance-genes-in-compost-originating-from-cattle-manure-after-direct-oral-administration-or-post-excretion-fortification-of-antimicrobials
#9
Shanwei Xu, Inoka D Amarakoon, Rahat Zaheer, Alanna Smith, Srinivas Sura, George Wang, Tim Reuter, Francis Zvomuya, Allan J Cessna, Francis J Larney, Tim A McAllister
Dissipation of antimicrobial resistance genes (ARG) during composting of cattle manure generated through fortification versus administration of antimicrobials in feed was compared. Manure was collected from cattle fed diets containing (kg-1) dry matter (DM): (1) 44 mg chlortetracycline (CTC), (2) a mixture of 44 mg each of chlortetracycline and sulfamethazine (CTCSMZ), (3) 11 mg tylosin (TYL) or (4) Control, no antimicrobials. Manures were composted for 30 d with a single mixing after 16 d to generate the second heating cycle...
December 7, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29215494/descriptive-analysis-of-state-and-federal-spine-surgery-malpractice-litigation-in-the-united-states
#10
Nitin Agarwal, Raghav Gupta, Prateek Agarwal, Pravin Matthew, Richard Wolferz Jr, Aakash Shah, Nimer Adeeb, Arpan V Prabhu, Adam S Kanter, David O Okonkwo, D Kojo Hamilton
STUDY DESIGN: Retrospective Review OBJECTIVE.: This study aimed to determine the factors associated with malpractice litigation in cases involving spine surgery in the United States. SUMMARY OF BACKGROUND DATA: Medical malpractice is of substantial interest to the medical community due to concerns of increased healthcare costs and medical decision-making for the sole purpose of reducing legal liability. METHODS: The Westlaw online legal database (Thomson Reuters, New York, NY) was searched for verdict and settlement reports pertaining to spine surgery from 2010 to 2015...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29209803/-ourpuppet-caring-support-with-an-interactive-puppet-for-informal-caregivers-opportunities-and-challenges-in-the-social-and-technical-developmental-process
#11
REVIEW
Andrea Kuhlmann, Verena Reuter, Renate Schramek, Todor Dimitrov, Matthias Görnig, Eva-Maria Matip, Olaf Matthies, Edwin Naroska
BACKGROUND: The "OurPuppet" project comprises a sensor-based, interactive puppet that will be developed to communicate with people in need of care during a short period of absence of the informal caregiver. Specially qualified puppet guides will support the use of the new technical development. They instruct people with dementia and caregivers on how to use the puppet and supervise the (informal) care relationship through discussions on a regular basis. OBJECTIVES: The article shows the specific components of users' needs for which the concrete technical development should find answers...
December 5, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29204771/comparison-of-blood-pressure-monitoring-by-applanation-tonometry-and-invasively-assessed-blood-pressure-in-cardiological-patients
#12
G Greiwe, S Hoffmann, L Herich, M S Winkler, C J Trepte, C R Behem, M Petzoldt, D A Reuter, S A Haas
The aim of this study was to evaluate the accuracy and precision of non-invasive continuous blood pressure measurement by applanation tonometry (AT) in awake or anaesthetised cardiological intensive care patients. Patients suffering from highly impaired left ventricular function atrial fibrillation or severe aortic valve stenosis were included into the study. Arterial blood pressure was recorded by applanation tonometry (T-Line 400, Tensys Medical®, USA) and an arterial line in awake or anaesthetised patients...
December 4, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29204663/-under-pressure-massive-tongue-swelling-after-cardiac-arrest
#13
C Adler, R Stangl, H Reuter, G Michels
No abstract text is available yet for this article.
December 4, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29200505/early-miocene-reef-and-mudflat-associated-gastropods-from-makran-se-iran
#14
Mathias Harzhauser, Markus Reuter, Tayebeh Mohtat, Werner E Piller
A new gastropod fauna of Burdigalian (early Miocene) age is described from the Iranian part of Makran. The fauna comprises 19 species and represents three distinct assemblages from turbid water coral reef, shallow subtidal soft-bottom and mangrove-fringed mudflat environments in the northern Indian Ocean. Especially the reef-associated assemblage comprises largely new species. This is explained by the rare occurrence of reefs along the northern margin of the Miocene Indian Ocean and the low number of scientific studies dealing with the region...
2017: Paläontologische Zeitschrift
https://www.readbyqxmd.com/read/29200504/science-production-in-germany-france-belgium-and-luxembourg-comparing-the-contributions-of-research-universities-and-institutes-to-science-technology-engineering-mathematics-and-health
#15
Justin J W Powell, Jennifer Dusdal
Charting significant growth in science production over the 20th century in four European Union member states, this neo-institutional analysis describes the development and current state of universities and research institutes that bolster Europe's position as a key region in global science. On-going internationalization and Europeanization of higher education and science has been accompanied by increasing competition as well as collaboration. Despite the policy goals to foster innovation and further expand research capacity, in cross-national and historical comparison neither the level of R&D investments nor country size accounts completely for the differential growth of scientific productivity...
2017: Minerva
https://www.readbyqxmd.com/read/29194875/heterologous-expression-biosynthetic-studies-and-ecological-function-of-the-selective-gq-signaling-inhibitor-fr900359
#16
Max Crüsemann, Raphael Reher, Isabella Schamari, Alexander O Brachmann, Tsubasa Ohbayashi, Markus Kuschak, Davide Malfacini, Alexander Seidinger, Marta Pinto-Carbó, René Richarz, Tatjana Reuter, Stefan Kehraus, Asis Hallab, Misty Attwood, Helgi B Schiöth, Peter Mergaert, Yoshitomo Kikuchi, Till F Schäberle, Evi Kostenis, Daniela Wenzel, Christa E Müller, Jörn Piel, Aurélien Carlier, Leo Eberl, Gabriele Maria Koenig
The cyclic depsipeptide FR900359 (FR), isolated from the tropical plant Ardisia crenata, displays a strong and selective inhibition of Gq proteins, making it an indispensable pharmacological tool to study Gq-related processes, as well as a promising drug candidate. Gq inhibition is a novel mode of action for defense chemicals and crucial for the ecological function of FR, as shown by in vivo experiments on mice, affinity to insect Gq proteins and insect toxicity studies. The uncultured endosymbiont of A. crenata, 'Candidatus Burkholderia crenata' was sequenced, revealing the FR nonribosomal peptide synthetase (frs) gene cluster...
December 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29180607/small-cell-carcinomas-of-the-bladder-and-lung-are-characterized-by-a-convergent-but-distinct-pathogenesis
#17
Matthew T Chang, Alexander V Penson, Neil B Desai, Nicholas D Socci, Ronglai Shen, Venkatraman Seshan, Ritika Kundra, Adam A Abeshouse, Agnes Viale, Eugene K Cha, Xueli Hao, Victor Reuter, Charles M Rudin, Bernard H Bochner, Jonathan E Rosenberg, Dean F Bajorin, Nikolaus Schultz, Michael F Berger, Gopa Iyer, David B Solit, Hikmat A Al-Ahmadie, Barry S Taylor
Background Small cell carcinoma of the bladder (SCCB) is a rare and aggressive neuroendocrine tumor with a dismal prognosis and limited treatment options. As SCCB is histologically indistinguishable from small cell lung cancer, a shared pathogenesis and cell of origin has been proposed. The aim of this study is to determine whether SCCBs arise from a pre-existent urothelial carcinoma or share a molecular pathogenesis in common with small cell lung cancer. Results We performed an integrative analysis of 61 SCCB tumors to identify histology- and organ-specific similarities and differences...
November 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29171821/a-controlled-trial-of-erenumab-for-episodic-migraine
#18
Peter J Goadsby, Uwe Reuter, Yngve Hallström, Gregor Broessner, Jo H Bonner, Feng Zhang, Sandhya Sapra, Hernan Picard, Daniel D Mikol, Robert A Lenz
BACKGROUND: We tested erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor, for the prevention of episodic migraine. METHODS: We randomly assigned patients to receive a subcutaneous injection of either erenumab, at a dose of 70 mg or 140 mg, or placebo monthly for 6 months. The primary end point was the change from baseline to months 4 through 6 in the mean number of migraine days per month. Secondary end points were a 50% or greater reduction in mean migraine days per month, change in the number of days of use of acute migraine-specific medication, and change in scores on the physical-impairment and everyday-activities domains of the Migraine Physical Function Impact Diary (scale transformed to 0 to 100, with higher scores representing greater migraine burden on functioning)...
November 30, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29164603/18f-pet-with-florbetapir-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#19
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Xavier Bonfill Cosp, Leon Flicker
BACKGROUND: 18F-florbetapir uptake by brain tissue measured by positron emission tomography (PET) is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using amyloid biomarkers tests like 18F-florbetapir...
November 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29164602/18f-pet-with-flutemetamol-for-the-early-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-in-people-with-mild-cognitive-impairment-mci
#20
REVIEW
Gabriel Martínez, Robin Wm Vernooij, Paulina Fuentes Padilla, Javier Zamora, Leon Flicker, Xavier Bonfill Cosp
BACKGROUND: 18F-flutemetamol uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dementia. Its added value is mainly demonstrated by excluding Alzheimer's pathology in an established dementia diagnosis. However, the National Institute on Aging and Alzheimer's Association (NIA-AA) revised the diagnostic criteria for Alzheimer's disease and the confidence in the diagnosis of mild cognitive impairment (MCI) due to Alzheimer's disease may be increased when using some amyloid biomarkers tests like 18F-flutemetamol...
November 22, 2017: Cochrane Database of Systematic Reviews
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