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Gregory Costain, Rebekah Jobling, Susan Walker, Miriam S Reuter, Meaghan Snell, Sarah Bowdin, Ronald D Cohn, Lucie Dupuis, Stacy Hewson, Saadet Mercimek-Andrews, Cheryl Shuman, Neal Sondheimer, Rosanna Weksberg, Grace Yoon, M Stephen Meyn, Dimitri J Stavropoulos, Stephen W Scherer, Roberto Mendoza-Londono, Christian R Marshall
Whole-genome sequencing (WGS) as a first-tier diagnostic test could transform medical genetic assessments, but there are limited data regarding its clinical use. We previously showed that WGS could feasibly be deployed as a single molecular test capable of a higher diagnostic rate than current practices, in a prospectively recruited cohort of 100 children meeting criteria for chromosomal microarray analysis. In this study, we report on the added diagnostic yield with re-annotation and reanalysis of these WGS data ~2 years later...
February 16, 2018: European Journal of Human Genetics: EJHG
Rayna Sariyska, Bernd Lachmann, Sebastian Markett, Martin Reuter, Christian Montag
No abstract text is available yet for this article.
June 2017: Addictive Behaviors Reports
Spencer C Evans, Christina M Amaro, Robyn Herbert, Jennifer B Blossom, Michael C Roberts
If a doctoral dissertation represents an original investigation that makes a contribution to one's field, then dissertation research could, and arguably should, be disseminated into the scientific literature. However, the extent and nature of dissertation publication remains largely unknown within psychology. The present study investigated the peer-reviewed publication outcomes of psychology dissertation research in the United States. Additionally, we examined publication lag, scientific impact, and variations across subfields...
2018: PloS One
Bernd Saugel, Daniel A Reuter
"Perioperative goal-directed therapy" (PGDT) aims at an optimization of basic and advanced global hemodynamic variables to maintain adequate oxygen delivery to the end-organs. PGDT protocols help to titrate fluids, vasopressors, or inotropes to hemodynamic target values. There is considerable evidence that PGDT can improve patient outcome in high-risk patients if both fluids and inotropes are administered to target hemodynamic variables reflecting blood flow. Despite this evidence, PGDT strategies aiming at an optimization of blood flow seem to be not well implemented in routine clinical care...
2018: Frontiers in Medicine
Suvi T Häkkinen, Lauri Reuter, Ninni Nuorti, Jussi J Joensuu, Heiko Rischer, Anneli Ritala
Plant cells constitute an attractive platform for production of recombinant proteins as more and more animal-free products and processes are desired. One of the challenges in using plant cells as production hosts has been the costs deriving from expensive culture medium components. In this work, the aim was to optimize the levels of most expensive components in the nutrient medium without compromising the accumulation of biomass and recombinant protein yields. Wild-type BY-2 culture and transgenic tobacco BY-2 expressing green fluorescent protein-Hydrophobin I (GFP-HFBI) fusion protein were used to determine the most inexpensive medium composition...
2018: Frontiers in Plant Science
Pedram Samani, Max Reuter
No abstract text is available yet for this article.
February 12, 2018: Nature Ecology & Evolution
Miriam S Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Neal Sondheimer, Ryan K C Yuen, Brett Trost, Tara A Paton, Sergio L Pereira, Jo-Anne Herbrick, Richard F Wintle, Daniele Merico, Jennifer Howe, Jeffrey R MacDonald, Chao Lu, Thomas Nalpathamkalam, Wilson W L Sung, Zhuozhi Wang, Rohan V Patel, Giovanna Pellecchia, John Wei, Lisa J Strug, Sherilyn Bell, Barbara Kellam, Melanie M Mahtani, Anne S Bassett, Yvonne Bombard, Rosanna Weksberg, Cheryl Shuman, Ronald D Cohn, Dimitri J Stavropoulos, Sarah Bowdin, Matthew R Hildebrandt, Wei Wei, Asli Romm, Peter Pasceri, James Ellis, Peter Ray, M Stephen Meyn, Nasim Monfared, S Mohsen Hosseini, Ann M Joseph-George, Fred W Keeley, Ryan A Cook, Marc Fiume, Hin C Lee, Christian R Marshall, Jill Davies, Allison Hazell, Janet A Buchanan, Michael J Szego, Stephen W Scherer
BACKGROUND: The Personal Genome Project Canada is a comprehensive public data resource that integrates whole genome sequencing data and health information. We describe genomic variation identified in the initial recruitment cohort of 56 volunteers. METHODS: Volunteers were screened for eligibility and provided informed consent for open data sharing. Using blood DNA, we performed whole genome sequencing and identified all possible classes of DNA variants. A genetic counsellor explained the implication of the results to each participant...
February 5, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Uwe Rudolf Max Reuter, Ralf Oettmeier, Uwe Hobohm
William Coley, between 1895 and 1936, treated hundreds of cancer patients using infusions of fever inducing bacerial extracts. Similar experiments were done by Klyuyeva and co-workers in the 1940ies in Russia using trypanosoma extracts. Many remissions and cures were reported. We have conjectured that pathogen associated molecular pattern substances (PAMP) are the molecular explanation for the beneficial treatments in both groups. We could show that a combination of PAMP can eradicate solid tumours in cancer mice if applied several times...
February 6, 2018: Translational Oncology
Lars Radünz, Hannah Reuter, Hilke Andresen-Streichert
Modafinil is used because of its wakefulness-promoting properties for treatment of diseases associated with extreme sleepiness (i.e., narcolepsy). Additionally, it is misused as a "cognitive enhancer" to increase alertness and to improve concentration. We present modafinil concentrations in serum samples in five cases of our routine work measured by high-performance liquid chromatography coupled with a photo diode array detector after solid-phase extraction. One sample was analyzed for clinical toxicology purposes...
February 7, 2018: Journal of Analytical Toxicology
Eva-Maria Reuter, Welber Marinovic, Jesse Beikoff, Timothy J Carroll
Alternative motor responses can be prepared in parallel. Here, we used electroencephalography (EEG) to test whether the parallel preparation of alternative response options is modulated by their relative value. Participants performed a choice response task with three potential actions: isometric contraction of the left, the right, or both wrists. An imperative stimulus (IS) appeared after a warning cue, such that the initiation time of a required action was predictable, but the specific action was not. To encourage advanced preparation, the target was presented 200 ms prior to the IS, and only correct responses initiated within ±100 ms of the IS were rewarded...
February 5, 2018: Neuroscience
Masarah Paquet-Clouston, David Décary-Hétu, Carlo Morselli
BACKGROUND: Since 2011, drug market participants have traded illegal drugs through cryptomarkets, a user-friendly infrastructure in which drug market participants can conduct business transactions. This study assesses market competition and the size and scope of drug vendors' activities on one of the largest cryptomarkets, AlphaBay, in order to better understand the challenges that drug vendors face when selling on this venue. METHODS: Relying on data collected from AlphaBay, we calculate the degree of competition within the drug market using the Herfindhal-Hirshmann Index (HHI)...
January 30, 2018: International Journal on Drug Policy
Stefan Schülke, Kirsten Kuttich, Sonja Wolfheimer, Nadine Duschek, Andrea Wangorsch, Andreas Reuter, Peter Briza, Isabel Pablos, Gabriele Gadermaier, Fatima Ferreira, Stefan Vieths, Masako Toda, Stephan Scheurer
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
February 6, 2018: Scientific Reports
Mi Zhou, Martin Hünerberg, Yanhong Chen, Tim Reuter, Tim A McAllister, Franklin Evans, Alan T Critchley, Le Luo Guan
The use of Tasco (air-dried Ascophyllum nodosum) as a feed supplement for ruminants has been reported to affect rumen fermentation and reduce Escherichia coli O157:H7 shedding in feces, but the mode of action behind this phenomenon is unclear. In this study, the effects of four Tasco levels (0, 1, 3, and 5%) on rumen microbiota and rumen/fecal E. coli O serogroups in rams were investigated. Rumen total bacteria and archaea were linearly reduced (P < 0.001) and protozoa were linearly increased (P < 0...
January 2018: MSphere
Janko van Beek, Miranda de Graaf, Haider Al-Hello, David J Allen, Katia Ambert-Balay, Nadine Botteldoorn, Mia Brytting, Javier Buesa, Maria Cabrerizo, Martin Chan, Fiona Cloak, Ilaria Di Bartolo, Susana Guix, Joanne Hewitt, Nobuhiro Iritani, Miao Jin, Reimar Johne, Ingeborg Lederer, Janet Mans, Vito Martella, Leena Maunula, Georgina McAllister, Sandra Niendorf, Hubert G Niesters, Alexander T Podkolzin, Mateja Poljsak-Prijatelj, Lasse Dam Rasmussen, Gábor Reuter, Gráinne Tuite, Annelies Kroneman, Harry Vennema, Marion P G Koopmans
BACKGROUND: The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. METHODS: We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at open reading frame (ORF) 1 and ORF2...
January 25, 2018: Lancet Infectious Diseases
Sebastian Wanke, Marian Strack, Carsten Dählmann, Kathrin Kuhr, Carsten Zobel, Hannes Reuter
BACKGROUND: Sudden cardiac arrest is still one of the most frequent causes of death. Teaching resuscitation in schools was already successfully implemented in Scandinavian countries. Following a recommendation of the conference of german stateministers of education in June 2014, additional tuition for resuscitation is to be implemented in german schools starting in seventh grade. METHODS: The present study aimed to assess the level of knowledge of seventh grade students in the field of life support and to implement curricular standards for resuscitation courses in secondary schools...
January 31, 2018: Wiener Medizinische Wochenschrift
John Zech, Margaret Pain, Joseph Titano, Marcus Badgeley, Javin Schefflein, Andres Su, Anthony Costa, Joshua Bederson, Joseph Lehar, Eric Karl Oermann
Purpose To compare different methods for generating features from radiology reports and to develop a method to automatically identify findings in these reports. Materials and Methods In this study, 96 303 head computed tomography (CT) reports were obtained. The linguistic complexity of these reports was compared with that of alternative corpora. Head CT reports were preprocessed, and machine-analyzable features were constructed by using bag-of-words (BOW), word embedding, and Latent Dirichlet allocation-based approaches...
January 30, 2018: Radiology
Rim Hamza, Meritxell Pérez-Hedo, Alberto Urbaneja, José L Rambla, Antonio Granell, Kamel Gaddour, José P Beltrán, Luis A Cañas
BACKGROUND: Plants and insects have coexisted for million years and evolved a set of interactions which affect both organisms at different levels. Plants have developed various morphological and biochemical adaptations to cope with herbivores attacks. However, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) has become the major pest threatening tomato crops worldwide and without the appropriated management it can cause production losses between 80 to 100%. RESULTS: The aim of this study was to investigate the in vivo effect of a serine proteinase inhibitor (BTI-CMe) and a cysteine proteinase inhibitor (Hv-CPI2) from barley on this insect and to examine the effect their expression has on tomato defensive responses...
January 25, 2018: BMC Plant Biology
Charles Awortwe, Memela Makiwane, Helmuth Reuter, Christo Muller, Johan Louw, Bernd Rosenkranz
AIM: The aim of this review was to assess the severity of adverse drug reactions (ADRs) due to herb-drug interactions in patients taking herbs and prescribed medications based on published evidence. METHOD: Electronic databases of PubMed, the Cochrane Library, Medline and Scopus were searched for randomized or non-randomized clinical studies, case-control and case reports of herb-drug interactions (HDI). The data was extracted and the causal relationship of ADRs as consequences of HDI assessed using Horn's drug interaction probability scale (DIPS) or Roussel Uclaf Causality Assessment Method (RUCAM) scoring systems...
January 24, 2018: British Journal of Clinical Pharmacology
Robert S White
No abstract text is available yet for this article.
December 26, 2017: Issue Brief of the Health Policy Tracking Service
Robert S White
No abstract text is available yet for this article.
December 26, 2017: Issue Brief of the Health Policy Tracking Service
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