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https://www.readbyqxmd.com/read/28649365/the-impact-factor-of-an-open-access-journal-does-not-contribute-to-an-article-s-citations
#1
S K Chua, Ahmad M Qureshi, Vijay Krishnan, Dinker R Pai, Laila B Kamal, Sharmilla Gunasegaran, M Z Afzal, Lahiru Ambawatta, J Y Gan, P Y Kew, Than Winn, Suneet Sood
Background Citations of papers are positively influenced by the journal's impact factor (IF). For non-open access (non-OA) journals, this influence may be due to the fact that high-IF journals are more often purchased by libraries, and are therefore more often available to researchers, than low-IF journals. This positive influence has not, however, been shown specifically for papers published in open access (OA) journals, which are universally accessible, and do not need library purchase. It is therefore important to ascertain if the IF influences citations in OA journals too...
2017: F1000Research
https://www.readbyqxmd.com/read/28644623/charge-transport-in-molecular-materials-an-assessment-of-computational-methods
#2
Harald Oberhofer, Karsten Reuter, Jochen Blumberger
The booming field of molecular electronics has fostered a surge of computational research on electronic properties of organic molecular solids. In particular, with respect to a microscopic understanding of transport and loss mechanisms, theoretical studies assume an ever-increasing role. Owing to the tremendous diversity of organic molecular materials, a great number of computational methods have been put forward to suit every possible charge transport regime, material, and need for accuracy. With this review article we aim at providing a compendium of the available methods, their theoretical foundations, and their ranges of validity...
June 23, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28640955/in-solution-antibody-harvesting-with-a-plant-produced-hydrophobin-protein-a-fusion
#3
Katri Kurppa, Lauri Reuter, Anneli Ritala, Markus Linder, Jussi Joensuu
Purification is a bottleneck and a major cost factor in the production of antibodies. We set out to engineer a bi-functional fusion protein from two building blocks, Protein A and a hydrophobin, aiming at low-cost and scalable antibody capturing in solutions. Immunoglobulin-binding Protein A is widely used in affinity-based purification. The hydrophobin fusion tag, on the other hand, has been shown to enable purification by two-phase separation. Protein A was fused to two different hydrophobin tags, HFBI or II, and expressed transiently in Nicotiana benthamiana...
June 22, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28636786/exacta-the-complement-system-in-kidney-diseases
#4
S Reuter, R Mrowka
The complement system, a plasma component, was described upon its discovery to augment the opsonisation of bacteria by antibodies, 'complementing' said antibodies' antibacterial activity. In its first and foremost role, the complement cascade helps convert pathogen recognition into an effective host defence. Two recent publications in Acta Physiologica have highlighted the role of complement factors in immune cell function, namely monoamine transmitter release from immune cells during immune response and inflammation(1, 2) This article is protected by copyright...
June 21, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28631980/orexin-research-patent-news-from-2016
#5
Christoph Boss, Catherine Roch
The orexin (hypocretin) system consists of two G-protein-coupled receptors, orexin 1 (Ox1) and orexin 2 (Ox2) and two endogenous peptidic ligands, orexin A (OxA) and orexin B (OxB). It is evolutionarily highly conserved. In the brain, it is involved in the promotion of wakefulness under motivational circumstances as well as in anxiety and addictive disorders. In addition, its activation via the Ox1 receptor triggers apoptosis in several cancer cell lines. Dual orexin receptor antagonists (DORAs) such as suvorexant are successfully used to treat primary insomnia...
June 20, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28623072/commentary-on-integrative-clinical-genomics-of-advanced-prostate-cancer-robinson-d-van-allen-em-wu-ym-schultz-n-lonigro-rj-mosquera-jm-montgomery-b-taplin-me-pritchard-cc-attard-g-beltran-h-abida-w-bradley-rk-vinson-j-cao-x-vats-p-kunju-lp-hussain-m-feng-fy
#6
Stephen J Freedland, William J Aronson
Toward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mCRPC affected individuals. Aberrations of AR, ETS genes, TP53, and PTEN were frequent (40%-60% of cases), with TP53 and AR alterations enriched in mCRPC compared to primary prostate cancer. We identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF...
June 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28617962/getting-to-no-pragmatic-and-semantic-factors-in-two-and-three-year-olds-understanding-of-negation
#7
Tracy Reuter, Roman Feiman, Jesse Snedeker
Although infants say "no" early, older children have difficulty understanding its truth-functional meaning. Two experiments investigate whether this difficulty stems from the infelicity of negative sentences out of the blue. In Experiment 1, given supportive discourse, 3-year-olds (N = 16) understood both affirmative and negative sentences. However, with sentence types randomized, 2-year-olds (N = 28) still failed. In Experiment 2, affirmative and negative sentences were blocked. Two-year-olds (N = 28) now succeeded, but only when affirmatives were presented first...
June 15, 2017: Child Development
https://www.readbyqxmd.com/read/28614987/role-of-amino-acid-supplementation-in-prevention-of-necrotizing-enterocolitis-in-preterm-neonates-a-review-of-current-evidences
#8
Bhawan Deep Garg, Nandkishor S Kabra
BACKGROUND: Necrotizing enterocolitis (NEC) is one of the most common acute and fatal gastrointestinal emergency in very low birth weight (VLBW) preterm neonates with mortality range from 15-30%. NEC is likely due to multifactorial process such as oxidative injury, ischemic necrosis and over reactive inflammatory response to intestinal microbes. AIMS: To evaluate the role of amino acid supplementation for reduction of neonatal NEC in preterm neonates. METHOD: The literature search was done for various randomized control trial (RCT) by searching the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS) and other data base...
June 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28606191/no-calm-after-the-storm-a-systematic-review-of-human-health-following-flood-and-storm-disasters
#9
Dell D Saulnier, Kim Brolin Ribacke, Johan von Schreeb
Introduction How the burden of disease varies during different phases after floods and after storms is essential in order to guide a medical response, but it has not been well-described. The objective of this review was to elucidate the health problems following flood and storm disasters. METHODS: A literature search of the databases Medline (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland USA); Cinahl (EBSCO Information Services; Ipswich, Massachusetts USA); Global Health (EBSCO Information Services; Ipswich, Massachusetts USA); Web of Science Core Collection (Thomson Reuters; New York, New York USA); Embase (Elsevier; Amsterdam, Netherlands); and PubMed (National Center for Biotechnology Information, National Institutes of Health; Bethesda, Maryland USA) was conducted in June 2015 for English-language research articles on morbidity or mortality and flood or storm disasters...
June 13, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28604654/postural-control-in-elite-decathlon-athletes-are-various-modes-of-dynamic-assessment-needed
#10
Sven Reuter, Philipp Forkel, Andreas B Imhoff, Knut Beitzel
BACKGROUND: Decathlon consists of various track and field running, jumping and throwing events. This results in high physical demands and poor postural control may predispose athletes at a higher risk for injury. The purpose of this study was to measure and to show a relationship of different dynamic postural control tests in healthy professional decathlon athletes. METHODS: The German top decathlon team (eight professional athletes, mean age±standard deviation (SD), 20...
July 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28604080/association-of-childhood-obesity-and-the-immune-system-a-systematic-review-of-reviews
#11
Roya Kelishadi, Mohammad Roufarshbaf, Sina Soheili, Farzaneh Payghambarzadeh, Mohsen Masjedi
The growing prevalence of childhood obesity has become a serious health problem over the past decades. As the immune system is greatly affected by excess weight, in this review of reviews, we discuss the findings of review articles about the relationship between childhood/maternal obesity and children's immune system. We searched English-language articles in PubMed, Scopus, ISI Thomson Reuters, and Google Scholar databases. All relevant reviews, either systematic or narrative, were retrieved. Then their quality was assessed by using the Assessment of Multiple Systematic Reviews and International Narrative Systematic Assessment tools, respectively...
June 12, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28600534/intracranial-fluid-redistribution-but-no-white-matter-microstructural-changes-during-a-spaceflight-analog
#12
Vincent Koppelmans, Ofer Pasternak, Jacob J Bloomberg, Yiri E De Dios, Scott J Wood, Roy Riascos, Patricia A Reuter-Lorenz, Igor S Kofman, Ajitkumar P Mulavara, Rachael D Seidler
The neural correlates of spaceflight-induced sensorimotor impairments are unknown. Head down-tilt bed rest (HDBR) serves as a microgravity analog because it mimics the headward fluid shift and axial body unloading of spaceflight. We investigated focal brain white matter (WM) changes and fluid shifts during 70 days of 6° HDBR in 16 subjects who were assessed pre (2x), during (3x), and post-HDBR (2x). Changes over time were compared to those in control subjects (n = 12) assessed four times over 90 days. Diffusion MRI was used to assess WM microstructure and fluid shifts...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28597523/corrigendum-formation-mechanism-of-the-first-carbon-carbon-bond-and-the-first-olefin-in-the-methanol-conversion-into-hydrocarbons
#13
Yue Liu, Sebastian Müller, Daniel Berger, Jelena Jelic, Karsten Reuter, Markus Tonigold, Maricruz Sanchez-Sanchez, Johannes A Lercher
No abstract text is available yet for this article.
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28592366/unmet-needs-for-information-and-psychosocial-support-in-relation-to-quality-of-life-and-emotional-distress-a-comparison-between-gynecological-and-breast-cancer-patients
#14
Hermann Faller, Elmar Brähler, Martin Härter, Monika Keller, Holger Schulz, Karl Wegscheider, Joachim Weis, Anna Boehncke, Katrin Reuter, Matthias Richard, Susanne Sehner, Uwe Koch, Anja Mehnert
OBJECTIVE: We compared gynecological and breast cancer patients regarding their needs for information and psychosocial support, quality of life (QoL), and emotional distress and the relationship among these constructs. METHODS: In a multicenter, cross-sectional study in Germany, we evaluated 1214 female cancer patients (317 with gynecological cancer, 897 with breast cancer). We obtained self-reports of unmet needs, using a self-developed measure. We measured QoL with the EORTC QLQ-C30, symptoms of depression with the Patient Health Questionnaire (PHQ-9), and symptoms of anxiety with the Generalized Anxiety Disorder Scale (GAD-7)...
May 24, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28591859/rhipicephalus-microplus-and-dermacentor-nitens-acari-ixodidae-coparasitize-white-tailed-deer-on-st-john-u-s-virgin-islands
#15
Suzanne L Nelson, Lance A Durden, Jon D Reuter
Ticks parasitizing introduced white-tailed deer, Odocoileus virginianus (Zimmermann), on St. John, U.S. Virgin Islands, were recorded during and after drought conditions. Tick infestation prevalences were 22% at the start of the drought (July 2015), 66% at the height of the drought (March 2016), and 35% after the drought had ended (July 2016; n = 67 deer). Samples of ticks from 22 tranquilized deer in July 2016 revealed the presence of two species, the southern cattle tick, Rhipicephalus (Boophilus) microplus (Canestrini), and the tropical horse tick, Dermacentor (Anocentor) nitens Neumann...
June 7, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28591768/adipose-derived-stem-cells-in-aesthetic-surgery-a-mixed-methods-evaluation-of-the-current-clinical-trial-intellectual-property-and-regulatory-landscape
#16
Zeeshaan Arshad, Celine-Lea Halioua-Haubold, Mackenna Roberts, Fulvio Urso-Baiarda, Oliver A Branford, David A Brindley, Benjamin M Davies, David Pettitt
Background: Adipose tissue, which can be readily harvested via a number of liposuction techniques, offers an easily accessible and abundant source of adipose-derived stem cells (ASCs). Consequently, ASCs have become an increasingly popular reconstructive option and a novel means of aesthetic soft tissue augmentation. Objectives: This paper examines recent advances in the aesthetic surgery field, extending beyond traditional review formats to incorporate a comprehensive analysis of current clinical trials, adoption status, and the commercialization pathway...
June 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28591708/methylation-of-hpv-and-a-tumor-suppressor-gene-reveals-anal-cancer-and-precursor-lesions
#17
Attila T Lorincz, Mayura Nathan, Caroline Reuter, Rhian Warman, Mohamed A Thaha, Michael Sheaff, Natasa Vasiljevic, Amar Ahmad, Jack Cuzick, Peter Sasieni
We studied DNA methylation patterns of human papillomavirus (HPV) and tumor suppressor gene EPB41L3 in 148 anal and perianal biopsies to determine whether high levels of methylation would be associated with anal intraepithelial neoplasia (AIN). The most prevalent HPV type was HPV16, detected in 54% of the 30 benign biopsies, 33% of the 43 low-grade AIN (lgAIN), 82% of the 59 high grade AIN (hgAIN) and 4 of the 5 anal cancers. A methylation score was developed (0.561*HPV16me+0.439*EPB41L3) which had increasing values with severity of disease: the mean was 8...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28586200/oligothiophene-bridged-conjugated-covalent-organic-frameworks
#18
Niklas Keller, Derya Bessinger, Stephan Reuter, Mona Calik, Laura Ascherl, Fabian C Hanusch, Florian Auras, Thomas Bein
Two-dimensional covalent organic frameworks (2D-COFs) are crystalline, porous materials comprising aligned columns of π-stacked building blocks. With a view toward the application of these materials in organic electronics and optoelectronics, the construction of oligothiophene-based COFs would be highly desirable. The realization of such materials, however, has remained a challenge, in particular with respect to laterally conjugated imine-linked COFs. We have developed a new building block design employing an asymmetric modification on an otherwise symmetric backbone that allows us to construct a series of highly crystalline quaterthiophene-derived COFs with tunable electronic properties...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28584236/superlattice-growth-and-rearrangement-during-evaporation-induced-nanoparticle-self-assembly
#19
Elisabeth Josten, Erik Wetterskog, Artur Glavic, Peter Boesecke, Artem Feoktystov, Elke Brauweiler-Reuters, Ulrich Rücker, German Salazar-Alvarez, Thomas Brückel, Lennart Bergström
Understanding the assembly of nanoparticles into superlattices with well-defined morphology and structure is technologically important but challenging as it requires novel combinations of in-situ methods with suitable spatial and temporal resolution. In this study, we have followed evaporation-induced assembly during drop casting of superparamagnetic, oleate-capped γ-Fe2O3 nanospheres dispersed in toluene in real time with Grazing Incidence Small Angle X-ray Scattering (GISAXS) in combination with droplet height measurements and direct observation of the dispersion...
June 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28577842/a-nationwide-rise-in-the-use-of-stents-for-benign-esophageal-perforation
#20
Lucas W Thornblade, Aaron M Cheng, Douglas E Wood, Michael S Mulligan, Michael D Saunders, Hao He, Brant K Oelschlager, David R Flum, Farhood Farjah
BACKGROUND: Surgical repair or drainage is the standard treatment for benign esophageal perforation. The United States Food and Drug Administration has approved the use of esophageal stents for the management of malignant esophageal stricture or fistula, or both. We hypothesize that increasing enthusiasm and experience with esophageal stents has led to greater use of stents for the management of benign esophageal perforation. METHODS: We performed a retrospective cohort study (2007 to 2014) of patients with benign esophageal perforation using MarketScan (Thomson Reuters, New York, NY), a commercial claims database...
July 2017: Annals of Thoracic Surgery
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