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Matthias Lischka, Georg S Michelitsch, Natalia Martsinovich, Johanna Eichhorn, Atena Rastgoo-Lahrood, Thomas Strunskus, Rochus Breuer, Karsten Reuter, Michael Schmittel, Markus Lackinger
Even though the surface-assisted dehalogenative coupling constitutes the most abundant protocol in on-surface synthesis, its full potential will only become visible if selectivity issues with polybrominated precursors are comprehensively understood, opening new venues for both organometallic self-assembly and on-surface polymerization. Using the 3,3',5,5'-tetrabromo-2,2',4,4',6,6'-hexafluorobiphenyl (Br4F6BP) at Ag(111), we demonstrate a remote site-selective functionalization at room temperature and a marked temperature difference in double- vs...
June 15, 2018: Nanoscale
Hui Shen, Juliann Shih, Daniel P Hollern, Linghua Wang, Reanne Bowlby, Satish K Tickoo, Vésteinn Thorsson, Andrew J Mungall, Yulia Newton, Apurva M Hegde, Joshua Armenia, Francisco Sánchez-Vega, John Pluta, Louise C Pyle, Rohit Mehra, Victor E Reuter, Guilherme Godoy, Jeffrey Jones, Carl S Shelley, Darren R Feldman, Daniel O Vidal, Davor Lessel, Tomislav Kulis, Flavio M Cárcano, Kristen M Leraas, Tara M Lichtenberg, Denise Brooks, Andrew D Cherniack, Juok Cho, David I Heiman, Katayoon Kasaian, Minwei Liu, Michael S Noble, Liu Xi, Hailei Zhang, Wanding Zhou, Jean C ZenKlusen, Carolyn M Hutter, Ina Felau, Jiashan Zhang, Nikolaus Schultz, Gad Getz, Matthew Meyerson, Joshua M Stuart, Rehan Akbani, David A Wheeler, Peter W Laird, Katherine L Nathanson, Victoria K Cortessis, Katherine A Hoadley
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma...
June 12, 2018: Cell Reports
Sun-Wei Guo, Patrick G Groothuis
BACKGROUND: The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endometriosis did not publish their results, and presumably failed. While few published trials did report how they foundered, the reasons why they failed are often completely unclear. Surprisingly, there has been no open discussion on why these trials failed. If the causes for these failed trials remain unelucidated, mistakes made in these failed trials may be repeated in the future...
June 11, 2018: Human Reproduction Update
G Adriana Perez, Karen Moomaw Rose, Billy A Caceres, Wanda Spurlock, Barbara Bowers, Barbara Lutz, Cynthia Arslanian-Engoren, Karin Reuter-Rice, Toby Bressler, Mona Wicks, Diana Taylor, Versie Johnson-Mallard, Elizabeth Kostas-Polston, Teresa Hagan, Desiree Bertrand, Susan C Reinhard
No abstract text is available yet for this article.
May 2018: Nursing Outlook
Joel Gambín-Botella, María Ayala, Joaquín Alfonso-Beltrán, Carlos Barrios
STUDY DESIGN: Bibliometric review of current literature. OBJECTIVE: To identify and analyze the characteristics of the 100 most cited articles on idiopathic scoliosis focusing on the level of evidence. SUMMARY OF BACKGROUND DATA: The scientific literature on idiopathic scoliosis has been constantly evolving, but many aspects of its true etiology, natural history, and response to treatment continue to be discussed. To date, no study has used bibliometric analysis to review the most influential articles about idiopathic scoliosis...
July 2018: Spine Deformity
Tamta Tkhilaishvili, Mariagrazia Di Luca, Gerardo Abbandonato, Elena Maryka Maiolo, Ann-Brit Klatt, Monika Reuter, Elisabeth Möncke-Buchner, Andrej Trampuz
Bacterial biofilms, highly resistant to the conventional antimicrobial therapy, remain an unresolved challenge pressing the medical community to investigate new and alternative strategies to fight chronic implant-associated infections. Recently, strictly lytic bacteriophages have been revalued as powerful agents to kill antibiotic-resistant bacteria even in biofilm. Here, the interaction of T3 bacteriophage and planktonic and biofilm Escherichia coli TG1, respectively, was evaluated using isothermal microcalorimetry...
June 7, 2018: Research in Microbiology
Christian Wachinger, Kwangsik Nho, Andrew J Saykin, Martin Reuter, Anna Rieckmann
BACKGROUND: Contralateral brain structures represent a unique, within-patient reference element for disease, and asymmetries can provide a personalized measure of the accumulation of past disease processes. Neuroanatomical shape asymmetries have recently been associated with the progression of Alzheimer's disease (AD), but the biological basis of asymmetric brain changes in AD remains unknown. METHODS: We investigated genetic influences on brain asymmetry by identifying associations between magnetic resonance imaging-derived measures of asymmetry and candidate single nucleotide polymorphisms (SNPs) that have previously been identified in genome-wide association studies for AD diagnosis and for brain subcortical volumes...
May 9, 2018: Biological Psychiatry
Julika Zimmermann, Nadja Deris, Christian Montag, Martin Reuter, Andrea Felten, Benjamin Becker, Bernd Weber, Sebastian Markett
Across species, the neuropeptide oxytocin has been associated with affiliative and social approach behavior. It has been suggested to exert its effects by modulating neural circuitry underlying anxiety, affiliative motivation, and social salience. The present study aims to investigate differences in subregional amygdala resting-state connectivity in healthy adult carries of different genotypes of the oxytocin receptor (OXTR) gene polymorphism rs2268498. Previous studies have associated this polymorphic locus with social cognitive and affiliative phenotypes...
June 6, 2018: NeuroImage
Kerstin Schott, Nina V Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
SAMHD1 is a critical restriction factor for HIV-1 in non-cycling cells and its antiviral activity is regulated by T592 phosphorylation. Here, we show that SAMHD1 dephosphorylation at T592 is controlled during the cell cycle, occurring during M/G1 transition in proliferating cells. Using several complementary proteomics and biochemical approaches, we identify the phosphatase PP2A-B55α responsible for rendering SAMHD1 antivirally active. SAMHD1 is specifically targeted by PP2A-B55α holoenzymes during mitotic exit, in line with observations that PP2A-B55α is a key mitotic exit phosphatase in mammalian cells...
June 8, 2018: Nature Communications
Samson W Fine, Hikmat A Al-Ahmadie, Ying-Bei Chen, Anuradha Gopalan, Satish K Tickoo, Victor E Reuter
From the advent of the Gleason grading system for prostate cancer, cancer displaying intraluminal necrotic cells and/or karyorrhexis within cribriform/solid architecture, a phenomenon termed "comedonecrosis," has been assigned pattern 5. Intraductal carcinoma (IDC-P) shows morphologic overlap with high-grade cribriform/solid adenocarcinoma architecturally and cytologically and may also show central necrosis, yet due to the presence of basal cells at the duct periphery is not currently assigned a grade in clinical practice...
June 6, 2018: American Journal of Surgical Pathology
Sean R Williamson, Priya Rao, Ondrej Hes, Jonathan I Epstein, Steven C Smith, Maria M Picken, Ming Zhou, Maria S Tretiakova, Satish K Tickoo, Ying-Bei Chen, Victor E Reuter, Stewart Fleming, Fiona M Maclean, Nilesh S Gupta, Naoto Kuroda, Brett Delahunt, Rohit Mehra, Christopher G Przybycin, Liang Cheng, John N Eble, David J Grignon, Holger Moch, Jose I Lopez, Lakshmi P Kunju, Pheroze Tamboli, John R Srigley, Mahul B Amin, Guido Martignoni, Michelle S Hirsch, Stephen M Bonsib, Kiril Trpkov
Staging criteria for renal cell carcinoma differ from many other cancers, in that renal tumors are often spherical with subtle, finger-like extensions into veins, renal sinus, or perinephric tissue. We sought to study interobserver agreement in pathologic stage categories for challenging cases. An online survey was circulated to urologic pathologists interested in kidney tumors, yielding 89% response (31/35). Most questions included 1 to 4 images, focusing on: vascular and renal sinus invasion (n=24), perinephric invasion (n=9), and gross pathology/specimen handling (n=17)...
June 6, 2018: American Journal of Surgical Pathology
Sunam Gurung, Alisha N Preno, Jamie P Dubaut, Hugh Nadeau, Kimberly Hyatt, Nicole Reuter, Bharti Nehete, Roman F Wolf, Pramod Nehete, Dirk P Dittmer, Dean A Myers, James F Papin
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus with devastating outcomes seen recently in the Americas due to the association of maternal ZIKV infection with fetal microcephaly and other fetal malformations not previously associated with flavivirus infections. Here, we have developed the olive baboon ( Papio anubis ) as a non-human primate (NHP) translational model for the study of ZIKV pathogenesis and associated disease outcomes to contrast and compare with humans and other major NHPs such as macaques...
June 6, 2018: Journal of Virology
Lining Shen, Bing Xiong, Wei Li, Fuqiang Lan, Richard Evans, Wei Zhang
BACKGROUND: In the last few decades, mobile technologies have been widely adopted in the field of health care services to improve the accessibility to and the quality of health services received. Mobile health (mHealth) has emerged as a field of research with increasing attention being paid to it by scientific researchers and a rapid increase in related literature being reported. OBJECTIVE: The purpose of this study was to analyze the current state of research, including publication outputs, in the field of mHealth to uncover in-depth collaboration characteristics and topic burst of international mHealth research...
June 5, 2018: JMIR MHealth and UHealth
Xiaopeng Guo, Lu Gao, Zihao Wang, Chenzhe Feng, Bing Xing
BACKGROUND: Many articles have been published on pituitary adenomas. Bibliometric analyses are helpful for determining the most impactful studies within a field. OBJECTIVE: To identify the top 100 most-cited articles on pituitary adenomas using the bibliometric analysis method. METHODS: We searched the Thomson Reuters Web of Science on March 31, 2018. Articles were listed in descending order by the total citation (TC) number, and the most-cited articles on pituitary adenomas were identified and analyzed...
June 2, 2018: World Neurosurgery
Eva-Maria Reuter, Gregory E P Pearcey, Timothy J Carroll
Although age-related declines in cognitive, sensory and motor capacities are well documented, current evidence is mixed as to whether or not aging impairs sensorimotor adaptation to a novel dynamic environment. More importantly, the extent to which any deficits in sensorimotor adaptation are due to general impairments in neural plasticity, or impairments in the specific processes that drive adaptation is unclear. Here we investigated whether there are age-related differences in electrophysiological responses to reaching endpoint and trajectory errors caused by a novel force field, and whether markers of error processing relate to the ability of older adults to adapt their movements...
June 2, 2018: Experimental Gerontology
Eva-Maria Reuter
No abstract text is available yet for this article.
June 5, 2018: Journal of Physiology
Katharina Springer, Sandra Reuter, Mandy Knüpfer, Lukas Schmauder, Philipp-Albert Sänger, Angela Felsl, Thilo M Fuchs
Yersinia enterocolitica is a pathogen that causes gastroenteritis in humans. Because of its low temperature-dependent insecticidal activity, it can oscillate between invertebrates and mammals as host organisms. The insecticidal activity of strain W22703 is associated with a pathogenicity island of 19 kb (Tc-PAI Ye ), which carries regulators and genes encoding the toxin complex (Tc). The island also harbors four phage-related and highly conserved genes of unknown functions, which are polycistronically transcribed...
June 4, 2018: Journal of Bacteriology
Mirco Glitscher, Kiyoshi Himmelsbach, Kathrin Woytinek, Reimar Johne, Andreas Reuter, Jelena Spiric, Luisa Schwaben, Arnold Grünweller, Eberhard Hildt
Every year, there are about 20 Mio hepatitis E virus (HEV) infections and 60,000 deaths that are associated with HEV worldwide. At the present, there exists no specific therapy for HEV. The natural compound silvestrol has a potent antiviral effect against the (-)-strand RNA-virus Ebola virus, and also against the (+)-strand RNA viruses Corona-, Picorna-, and Zika virus. The inhibitory effect on virus spread is due to an inhibition of the DEAD-box RNA helicase eIF4A, which is required to unwind structured 5'-untranslated regions (UTRs)...
June 2, 2018: Viruses
Arzu Angı, Regina Sinelnikov, Hendrik Heenen, Al Meldrum, Jonathan Veinot, Christoph Scheurer, Karsten Reuter, Or Ashkenazi, Doron Azulay, Isaac Balberg, Oded Millo, Bernhard Rieger
Developing new methods, other than size and shape, for controlling the optoelectronic properties of semiconductor nanocrystals is a highly desired target. Here we demonstrate that the photoluminescence (PL) of silicon nanocrystals (SiNCs) can be tuned in the range 685-800 nm solely via surface functionalization with alkynyl(aryl) (phenylacetylene, 2-ethynylnaphthalene, 2-ethynyl-5-hexylthiophene) surface groups. Scanning tunnelling microscopy/spectroscopy (STM/STS) on single nanocrystals revealed the formation of new in-gap states adjacent to the conduction band edge of the functionalized SiNCs...
June 4, 2018: Nanotechnology
Christina Behrens, Inna Biela, Stéphanie Petiot-Bécard, Thomas Botzanowski, Sarah Cianférani, Christoph P Sager, Gerhard Klebe, Andreas Heine, Klaus Reuter
The bacterial enzyme tRNA-guanine transglycosylase (TGT) is involved in the biosynthesis of queuosine, a modified nucleoside present in the anticodon wobble position of tRNAsHis,Tyr,Asp,Asn. Although it forms a stable homodimer endowed with two active sites, it is, for steric reasons, able to bind and convert only one tRNA molecule at a time. In contrast, its mammalian counterpart constitutes a heterodimer consisting of a catalytic and a noncatalytic subunit, referred to as QTRT1 and QTRT2, respectively. Both subunits are homologous to the bacterial enzyme, yet only QTRT1 possesses all the residues required for substrate binding and catalysis...
June 4, 2018: Biochemistry
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