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Tamil Selvan Natarajan, Shigeru Okamoto, Klaus Werner Stöckelhuber, Sven Wiessner, Uta Reuter, Dieter Fischer, Anik Ghosh, Gert Heinrich, Amit Das
A mechanically adaptable elastomer composite is prepared with reversible soft-stiff properties that can be easily controlled. By the exploitation of different morphological structures of calcium sulphate, which is acting as active filler in soft elastomer matrix, the magnitude of filler reinforcement can be reversibly altered that will be reflected in changes of the final stiffness of the material. The higher stiffness, in other words, the higher modulus of the composites, is realized by the in-situ development of fine nano-structured calcium sulphate di-hydrate crystals, which are formed during exposure to water and, further, this highly reinforcing crystals can be transformed to a non-reinforcing hemi-hydrate mesocrystalline structure by simply heating the system in a controlled way...
April 20, 2018: ACS Applied Materials & Interfaces
Jolanda M Schwarz, Eberhard D Pracht, Daniel Brenner, Martin Reuter, Tony Stöcker
PURPOSE: The aim of this project was to develop a GRAPPA-based reconstruction for wave-CAIPI data. Wave-CAIPI fully exploits the 3D coil sensitivity variations by combining corkscrew k-space trajectories with CAIPIRINHA sampling. It reduces artifacts and limits reconstruction induced spatially varying noise enhancement. The GRAPPA-based wave-CAIPI method is robust and does not depend on the accuracy of coil sensitivity estimations. METHODS: We developed a GRAPPA-based, noniterative wave-CAIPI reconstruction algorithm utilizing multiple GRAPPA kernels...
April 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Kathryn E Engelhardt, Quentin Reuter, Jessica Liu, Jonathan F Bean, Joliette Barnum, Michael B Shapiro, Allison Ambre, Amanda Dunbar, Mara Markzon, Tara Reddy, Christine Schilling, Joseph Posluszny
BACKGROUND: Frail geriatric trauma and emergency general surgery (TEGS) patients have longer lengths of stay (LOS), more readmissions, and higher rates of post-discharge institutionalization than their non-frail counterparts. Despite calls to action by national trauma coalitions, there are few published reports of prospective interventions. The objective of this quality improvement (QI) project was to first develop a frailty screening program, and, then, if frail, implement a novel Frailty Pathway to reduce LOS, 30-day readmissions, and loss of independence (LOI)...
April 13, 2018: Journal of Trauma and Acute Care Surgery
Marcus Buggert, Son Nguyen, Laura M McLane, Maria Steblyanko, Nadia Anikeeva, Dominic Paquin-Proulx, Perla M Del Rio Estrada, Yuria Ablanedo-Terrazas, Kajsa Noyan, Morgan A Reuter, Korey Demers, Johan Sandberg, Michael A Eller, Hendrik Streeck, Marianne Jansson, Piotr Nowak, Anders Sönnerborg, David H Canaday, Ali Naji, E John Wherry, Merlin Robb, Steven G Deeks, Gustavo Reyes-Teran, Yuri Sykulev, Annika C Karlsson, Michael R Betts
CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that circulating effector CD4+ T cells may play a direct role in control of HIV replication through cytolytic activity or autocrine β-chemokine production. However, it remains unclear whether effector CD4+ T cell populations expressing cytolytic molecules and β-chemokines are present within lymph nodes (LNs), a major site of HIV replication. Here, we report that expression of β-chemokines and cytolytic molecules are enriched within a CD4+ T cell population with high levels of the T-box transcription factors T-bet and eomesodermin (Eomes)...
April 13, 2018: PLoS Pathogens
Sarah-Jo Paquette, Kim Stanford, James Thomas, Tim Reuter
Often Escherichia coli are harmless and/or beneficial bacteria inhabiting the gastrointestinal tract of livestock and humans. However, Shiga toxin-producing E. coli (STEC) have been linked to human disease. Cattle are the primary reservoir for STEC and STEC "super-shedders" are considered to be a major contributor in animal to animal transmission. Among STEC, O157:H7 is the most recognized serotype, but in recent years, non-O157 STEC have been increasingly linked to human disease. In Argentina and Germany, O178 is considered an emerging pathogen...
2018: PloS One
Veruska Andrea Santos, Dessana David Carvalho, Michael Van Ameringen, Antonio Egidio Nardi, Rafael Christophe Freire
Anxiety disorders are the largest group of mental disorders and a leading cause of impairment, implicating in high costs for health systems and society. Effective pharmacological and psychological treatments are available, but a significant fraction of these patients does not respond adequately to these treatments. The objective of this study is to identify neuroimaging findings that could predict response to psychotherapy in anxiety disorders. METHODS: The authors reviewed psychotherapy clinical trials with neuroimaging conducted with patients with anxiety disorders...
April 5, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
Heike Israel, Lars Neeb, Uwe Reuter
PURPOSE OF REVIEW: CGRP is a key neuropeptide in migraine pathophysiology. The blockade of the CGRP pathway at the side of the CGRP receptor of the CGRP peptide leads to the interruption of trigeminal nerve system-mediated headache syndromes such as migraine. Monoclonal antibodies (mAbs) targeting the CGRP pathway have been developed and are currently under investigation for episodic (EM) and chronic migraine (CM) prevention. Here, we report data from these clinical trials. RECENT FINDINGS: Placebo-controlled, randomized double-blind phase studies of CGRP mAbs in episodic and chronic migraine have shown that the specific blockade of the peptide or the CGRP receptor are both powerful mechanisms to reduce migraine frequency...
April 6, 2018: Current Pain and Headache Reports
Hongdou Ding, Xiao Song, Linsong Chen, Xinlin Zheng, Gening Jiang
BACKGROUND: The status of citations can reflect the impact of a paper and its contribution to surgical practice. The aim of our study was to identify and review the 100 most-cited papers in general thoracic surgery. MATERIALS AND METHODS: Relevant papers on general thoracic surgery were searched through Thomson Reuters Web of Science in the last week of November 2017. Results were returned in descending order of total citations. Their titles and abstracts were reviewed to identify whether they met our inclusion criteria by two thoracic surgeons independently...
April 2, 2018: International Journal of Surgery
Václav Vavryčuk
The main drawback of ranking of researchers by the number of papers, citations or by the Hirsch index is ignoring the problem of distributing authorship among authors in multi-author publications. So far, the single-author or multi-author publications contribute to the publication record of a researcher equally. This full counting scheme is apparently unfair and causes unjust disproportions, in particular, if ranked researchers have distinctly different collaboration profiles. These disproportions are removed by less common fractional or authorship-weighted counting schemes, which can distribute the authorship credit more properly and suppress a tendency to unjustified inflation of co-authors...
2018: PloS One
Christopher J Ricketts, Aguirre A De Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi, Bhavani Krishnan, David J Kwaitkowski, Wembin Lui, Maria J Merino, Gordon B Mills, Jerome Myers, Michael L Nickerson, Victor E Reuter, Laura S Schmidt, C Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G Vincent, Cathy D Vocke, David A Wheeler, Lixing Yang, William T Kim, A Gordon Robertson, Paul T Spellman, W Kimryn Rathmell, W Marston Linehan
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers...
April 3, 2018: Cell Reports
Bianca Raffaelli, Uwe Reuter
Calcitonin gene-related peptide (CGRP) is 37-amino-acid neuropeptide, crucially involved in migraine pathophysiology. Four monoclonal antibodies (mAbs) targeting the CGRP pathway are currently under evaluation for the prevention of episodic and chronic migraine: eptinezumab (ALD403), fremanezumab (TEV-48125), galcanezumab (LY2951742), and erenumab (AMG334). As reviewed in this article, all 4 antibodies have been proven effective, tolerable, and safe as migraine prophylactic treatments in phase II clinical trials...
April 3, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Ana Tur-Porcar, Alicia Mas-Tur, José M Merigó, Norat Roig-Tierno, John Watt
The Journal of Psychology: Interdisciplinary and Applied is a leading international journal in psychology dating back to 1935. This study examines its publications since its creation utilizing a bibliometric analysis. The primary objective is to provide a complete overview of the key factors affecting the journal. This analysis includes such key issues as the publication and citation structure of the journal, its most cited articles, and the leading authors, institutions, and countries referenced in the journal...
April 3, 2018: Journal of Psychology
Hamid Reza Koohestani, Seyed Kamran Soltani Arabshahi, Ladan Fata, Fazlollah Ahmadi
Introduction: The demand for mobile learning in the medical science educational program is increasing. The present review study gathers evidence highlighted by the experimental studies on the educational effects of mobile learning for medical science students. Methods: The study was carried out as a systematic literature search published from 2007 to July 2017 in the databases PubMed/Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Knowledge (Thomson Reuters) , Educational Resources and Information Center (ERIC), EMBASE (Elsevier), Cochrane library, PsycINFO and Google Scholar...
April 2018: Journal of Advances in Medical Education & Professionalism
Tracy Reuter, Lauren Emberson, Alexa Romberg, Casey Lew-Williams
Children who generate and update verbal predictions have larger vocabularies, suggesting that prediction may be a mechanism that supports language learning. We hypothesize that this relation is not confined to the domain of language, but instead signals a broader individual difference in information processing. To investigate this possibility, we tested infants (n = 50) in the early stages of vocabulary development (12-24 months) on their ability to generate and update nonverbal, visual predictions. In an eye-tracking task, a central fixation reliably preceded a peripheral target...
March 30, 2018: Cognition
Dirk Schramm, Marvin Reuter, Linus B Grabenhenrich, Antje Schuster, Christiane Lex, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Renate L Bergmann, Karl E Bergmann, Ulrich Wahn, Thomas Keil, Susanne Lau
BACKGROUND: Interaction of respiratory multimorbidity and lung function has not been examined in longitudinal population studies. We aimed to assess the association of multimorbidity of asthma and rhinitis with lung function and bronchial hyperresponsiveness in comparison to single and no allergies from early school age to young adulthood. METHODS: In 1990, the Multicenter Allergy Study birth cohort recruited 1314 newborns from 5 German cities. At 7, 13 and 20 years, we performed lung function and bronchial challenge tests...
March 31, 2018: Pediatric Allergy and Immunology
Sumit Isharwal, Hongying Huang, Gouri Nanjangud, François Audenet, Ying-Bei Chen, Anuradha Gopalan, Samson W Fine, Satish K Tickoo, Byron H Lee, Gopa Iyer, Kalyani Chadalavada, Jonathan E Rosenberg, Dean F Bajorin, Harry W Herr, S Machele Donat, Guido Dalbagni, Bernard H Bochner, David B Solit, Victor E Reuter, Hikmat A Al-Ahmadie
Micropapillary urothelial carcinoma (MPUC) is a rare but an aggressive variant of urothelial carcinoma. MPUC has been shown to commonly exhibit ERBB2 amplification and HER2 protein overexpression, but the frequency and distribution of these findings within micropapillary (MP) and not otherwise specified (NOS) components of tumors have not been addressed. Therefore, we evaluated ERBB2 amplification and HER2 expression in 43 MPUC cases by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC)...
March 27, 2018: Human Pathology
Sarra Bouagga, Alberto Urbaneja, Meritxell Pérez-Hedo
The combined release of Orius laevigatus (Fieber) (Hemiptera: Anthocoridae) with Amblyseius swirskii (Athias-Henriot) (Acari: Phytoseiidae) provides effective control of sweet pepper key pests, such as thrips and whiteflies. However, the management of the aphids can still be improved. Recently, the predatory mirids Nesidiocoris tenuis (Reuter) (Hemiptera: Miridae) and Macrolophus pygmaeus (Rambur) (Hemiptera: Miridae) have been found to be effective in the control of aphids, thrips and whiteflies when tested alone...
March 27, 2018: Journal of Economic Entomology
Martin Asker, Hannah L Brooke, Markus Waldén, Ulrika Tranaeus, Fredrik Johansson, Eva Skillgate, Lena W Holm
OBJECTIVE: To assess the evidence for risk factors and prevention measures for shoulder injuries in overhead sports. DESIGN: Systematic review with best-evidence synthesis. DATA SOURCES: Medline (Ovid), PubMed (complementary search), Embase (Elsevier), Cochrane (Wiley), SPORTDiscus (Ebsco) and Web of Science Core Collection (Thomson Reuters), from 1 January 1990 to 15 May 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials, cohort studies and case-control studies on risk factors or prevention measures for shoulder injuries in overhead sports...
March 26, 2018: British Journal of Sports Medicine
D A Reuter, S Kalman
No abstract text is available yet for this article.
April 2018: British Journal of Anaesthesia
Bryce Pardo, Peter Reuter
No abstract text is available yet for this article.
March 21, 2018: Lancet Psychiatry
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