keyword
https://read.qxmd.com/read/36567329/pre-operative-kidney-biomarkers-and-risks-for-death-cardiovascular-and-chronic-kidney-disease-events-after-cardiac-surgery-the-tribe-aki-study
#1
MULTICENTER STUDY
George Vasquez-Rios, Dennis G Moledina, Yaqi Jia, Eric McArthur, Sherry G Mansour, Heather Thiessen-Philbrook, Michael G Shlipak, Jay L Koyner, Amit X Garg, Chirag R Parikh, Steven G Coca
BACKGROUND: Soluble tumor necrosis factor receptor (sTNFR)1, sTNFR2, and plasma kidney injury molecule-1 (KIM-1) are associated with kidney events in patients with and without diabetes. However, their associations with clinical outcomes when obtained pre-operatively have not been explored. METHODS: The TRIBE-AKI cohort study is a prospective, multicenter, cohort study of high-risk adults undergoing cardiac surgery. We assessed the associations between pre-operative concentrations of plasma sTNFR1, sTNFR2, and KIM-1 and post-operative long-term outcomes including mortality, cardiovascular events, and chronic kidney disease (CKD) incidence or progression after discharge...
December 25, 2022: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/36404761/real-world-evidence-and-clinical-utility-of-kidneyintelx-on-patients-with-early-stage-diabetic-kidney-disease-interim-results-on-decision-impact-and-outcomes
#2
JOURNAL ARTICLE
Joji Tokita, Aida Vega, Catherine Sinfield, Nidhi Naik, Shivani Rathi, Sharlene Martin, Stephanie Wang, Leonard Amoruso, Azadeh Zabetian, Steven G Coca, Girish N Nadkarni, Fergus Fleming, Michael J Donovan, Robert Fields
INTRODUCTION AND OBJECTIVE: The lack of precision to identify patients with early-stage diabetic kidney disease (DKD) at near-term risk for progressive decline in kidney function results in poor disease management often leading to kidney failure requiring unplanned dialysis. The KidneyIntelX is a multiplex, bioprognostic, immunoassay consisting of 3 plasma biomarkers and clinical variables that uses machine learning to generate a risk score for progressive decline in kidney function over 5-year in adults with early-stage DKD...
2022: Journal of Primary Care & Community Health
https://read.qxmd.com/read/36245651/a-post-hoc-analysis-of-kidneyintelx-and-cardiorenal-outcomes-in-diabetic-kidney-disease
#3
JOURNAL ARTICLE
Girish N Nadkarni, Dipti Takale, Bruce Neal, Kenneth W Mahaffey, Yshai Yavin, Michael K Hansen, Fergus Fleming, Hiddo J L Heerspink, Steven G Coca
KidneyIntelX, a bioprognostic test for assessing risk of CKD progression, risk stratified individuals for kidney, heart failure, and death outcomes in the Canagliflozin Cardiovascular Assessment Study.Individuals scored as high risk seemed to derive more of benefit from treatment with canagliflozin versus placebo.These findings may serve to increase adoption of underutilized therapies for cardiorenal risk reduction in patients with diabetic kidney disease.
September 29, 2022: Kidney360
https://read.qxmd.com/read/35835005/acute-changes-in-serum-creatinine-are-not-a-meaningful-metric-in-randomized-controlled-trials-and-clinical-care
#4
REVIEW
Steven G Coca
BACKGROUND: Acute changes in serum creatinine are labeled clinically as acute kidney injury (AKI). However, not all acute changes in serum creatinine are deleterious and need to be acted upon. SUMMARY: Intravenous fluids in response to AKI should be judiciously administered, and volume overload should be avoided. Since congestion is the driver of poor outcomes in patients with acute decompensated heart failure and must be managed, AKI that occurs at the expense of decongestion does not confer increased risk...
July 14, 2022: Nephron
https://read.qxmd.com/read/35404425/recurrence-of-immune-complex-and-complement-mediated-membranoproliferative-glomerulonephritis-in-kidney-transplantation
#5
JOURNAL ARTICLE
Fernando Caravaca-Fontán, Natalia Polanco, Blanca Villacorta, Anna Buxeda, Armando Coca, Ana Ávila, Rocío Martínez-Gallardo, Cristina Galeano, Rosalía Valero, Natalia Ramos, Natalia Allende, Leónidas Cruzado-Vega, María José Pérez-Sáez, Ángel Sevillano, Esther González, Ana Hernández, Emilio Rodrigo, Mario Fernández-Ruiz, José María Aguado, Miguel Ángel Pérez Valdivia, Julio Pascuall, Amado Andrés, Manuel Praga
INTRODUCTION: Membranoproliferative glomerulonephritis (MPGN) represents a histologic pattern of glomerular injury that may be due to several aetiologies. Few studies have comprehensively analysed the recurrence of MPGN according to the current classification system. METHODS: We collected a multicentre, retrospective cohort of 220 kidney graft recipients with biopsy-proven native kidney disease due to MPGN between 1981 and 2021 in 11 hospitals. Demographic, clinical and histologic parameters of prognostic interest were collected...
January 23, 2023: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/35320154/clinical-functional-and-mental-health-outcomes-in-kidney-transplant-recipients-3-months-after-a-diagnosis-of-covid-19
#6
JOURNAL ARTICLE
Raphaël Duivenvoorden, Priya Vart, Marlies Noordzij, Augusto C Soares Dos Santos, Alex B Zulkarnaev, Casper F M Franssen, Dirk Kuypers, Erol Demir, Hormat Rahimzadeh, Julia Kerschbaum, Kitty J Jager, Kultigin Turkmen, Marc H Hemmelder, Marcel Schouten, María Luisa Rodríguez-Ferrero, Marta Crespo, Ron T Gansevoort, Luuk B Hilbrands
BACKGROUND: Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)-related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in patients who survive COVID-19. METHODS: We analyzed data from adult kidney transplant patients in the European Renal Association COVID-19 Database who presented with COVID-19 between February 1, 2020, and January 31, 2021. RESULTS: We included 912 patients with a mean age of 56...
May 1, 2022: Transplantation
https://read.qxmd.com/read/35145181/impact-of-intra-abdominal-pressure-on-early-kidney-transplant-outcomes
#7
JOURNAL ARTICLE
Armando Coca, Carlos Arias-Cabrales, María José Pérez-Sáez, Verónica Fidalgo, Pablo González, Isabel Acosta-Ochoa, Arturo Lorenzo, María Jesús Rollán, Alicia Mendiluce, Marta Crespo, Julio Pascual, Juan Bustamante-Munguira
Increased intra-abdominal pressure (IAP) is common among post-surgical patients and may cause organ dysfunction. However, its impact after kidney transplantation on early postoperative complications and graft recovery remains unclear. We designed a prospective, observational cohort study to describe the prevalence and determinants of IAP, as well as its effect on delayed graft function, postoperative complications, and graft recovery. IAP was measured in 205 kidney transplant recipients every 8 h during the first 72 h after surgery using the urinary bladder technique...
February 10, 2022: Scientific Reports
https://read.qxmd.com/read/34877213/cocaine-hurts-your-kidneys-too-a-rare-case-of-acute-interstitial-nephritis-caused-by-cocaine-abuse
#8
Tahmina Jahir, S M Sadaf Hossain, Ruby Risal, Marie Schmidt, Danilo Enriquez, Mobasera Bagum
Cocaine is a powerfully addictive recreational drug that is extracted from the leaves of the Erythroxylon coca plant native to Central and South America. It is a widely abused substance, despite being banned since the early 19th century due to fatalities. Cocaine may result in acute kidney injury (AKI) by different mechanisms, but acute interstitial nephritis (AIN) is scarcely recognized as the cause of acute kidney injury (AKI). Here, we present a case of AKI from both AIN and acute tubular necrosis (ATN) following cocaine insufflation...
November 2021: Curēus
https://read.qxmd.com/read/34752914/associations-of-plasma-biomarkers-of-inflammation-fibrosis-and-kidney-tubular-injury-with-progression-of-diabetic-kidney-disease-a-cohort-study
#9
JOURNAL ARTICLE
Orlando M Gutiérrez, Michael G Shlipak, Ronit Katz, Sushrut S Waikar, Jason H Greenberg, Sarah J Schrauben, Steven Coca, Chirag R Parikh, Ramachandran S Vasan, Harold I Feldman, Paul L Kimmel, Mary Cushman, Joseph V Bonventre, Mark J Sarnak, Joachim H Ix
RATIONALE & OBJECTIVE: Most circulating biomarkers of chronic kidney disease (CKD) progression focus on factors reflecting glomerular filtration. Few biomarkers capture nonglomerular pathways of kidney injury or damage, which may be particularly informative in populations at high risk for CKD progression such as individuals with diabetes. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: 594 participants (mean age, 70 years; 53% women) of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study who had diabetes and an estimated glomerular filtration rate (eGFR)<60mL/min/1...
June 2022: American Journal of Kidney Diseases
https://read.qxmd.com/read/34357841/healthcare-utilization-and-expenditures-associated-with-hyperkalemia-management-a-retrospective-study-of-medicare-advantage-patients
#10
JOURNAL ARTICLE
Nihar R Desai, Paula J Alvarez, Ladan Golestaneh, Steven D Woods, Steven G Coca, Christopher G Rowan
AIMS: This study aimed to estimate the association of patiromer exposure vs. no potassium (K+ ) binder (NoKb) exposure with healthcare utilization and expenditures among a cohort of Medicare Advantage patients with hyperkalemia (HK). METHODS: Using Optum's Clinformatics Data Mart (study period 2016-2019), the authors assessed propensity score-matched patients (1:1) with a serum K+ concentration ≥5.0 mmol/L and an HK diagnosis that were exposed to patiromer or NoKb on baseline characteristics...
January 2021: Journal of Medical Economics
https://read.qxmd.com/read/33344488/outcomes-of-covid-19-among-hospitalized-patients-with-non-dialysis-ckd
#11
JOURNAL ARTICLE
Armando Coca, Carla Burballa, Francisco Javier Centellas-Pérez, María José Pérez-Sáez, Elena Bustamante-Munguira, Agustín Ortega, Carlos Dueñas, María Dolores Arenas, Juan Pérez-Martínez, Guadalupe Ruiz, Marta Crespo, Francisco Llamas, Juan Bustamante-Munguira, Julio Pascual
Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19. Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19...
2020: Frontiers in Medicine
https://read.qxmd.com/read/33290282/biomarkers-of-inflammation-and-repair-in-kidney-disease-progression
#12
JOURNAL ARTICLE
Jeremy Puthumana, Heather Thiessen-Philbrook, Leyuan Xu, Steven G Coca, Amit X Garg, Jonathan Himmelfarb, Pavan K Bhatraju, T Alp Ikizler, Edward D Siew, Lorraine B Ware, Kathleen D Liu, Alan S Go, James S Kaufman, Paul L Kimmel, Vernon M Chinchilli, Lloyd G Cantley, Chirag R Parikh
INTRODUCTIONAcute kidney injury and chronic kidney disease (CKD) are common in hospitalized patients. To inform clinical decision making, more accurate information regarding risk of long-term progression to kidney failure is required.METHODSWe enrolled 1538 hospitalized patients in a multicenter, prospective cohort study. Monocyte chemoattractant protein 1 (MCP-1/CCL2), uromodulin (UMOD), and YKL-40 (CHI3L1) were measured in urine samples collected during outpatient follow-up at 3 months. We followed patients for a median of 4...
February 1, 2021: Journal of Clinical Investigation
https://read.qxmd.com/read/33272913/prospective-cohort-study-of-renin-angiotensin-system-blocker-usage-after-hospitalized-acute-kidney-injury
#13
MULTICENTER STUDY
Sandeep Brar, Kathleen D Liu, Alan S Go, Raymond K Hsu, Vernon M Chinchilli, Steven G Coca, Amit X Garg, Jonathan Himmelfarb, T Alp Ikizler, James Kaufman, Paul L Kimmel, Chirag R Parikh, Edward D Siew, Lorraine B Ware, Hui Zeng, Chi-Yuan Hsu
BACKGROUND AND OBJECTIVES: The risk-benefit ratio of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy after AKI may be altered due to concerns regarding recurrent AKI. We evaluated, in a prospective cohort, the association between use (versus nonuse) of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and the subsequent risk of AKI and other adverse outcomes after hospitalizations with and without AKI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied 1538 patients recently discharged from the hospital who enrolled in the multicenter, prospective ASSESS-AKI study, with approximately half of patients experiencing AKI during the index hospitalization...
December 31, 2020: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/32954072/systematic-review-of-the-association-between-worsening-renal-function-and-mortality-in-patients-with-acute-decompensated-heart-failure
#14
JOURNAL ARTICLE
Takayuki Yamada, Hiroki Ueyama, Nitin Chopra, Takahiro Yamaji, Kengo Azushima, Ryu Kobayashi, Sho Kinguchi, Shingo Urate, Toru Suzuki, Eriko Abe, Yusuke Saigusa, Hiromichi Wakui, Paulina Partridge, Alfred Burger, Claudio A Bravo, Maria A Rodriguez, Juan Ivey-Miranda, Kouichi Tamura, Jeffery Testani, Steven Coca
Introduction: Outcomes in acute decompensated heart failure (ADHF) have remained poor. Worsening renal function (WRF) is common among patients with ADHF. However, the impact of WRF on the prognosis is controversial. We hypothesized that in patients with ADHF, the achievement of concomitant decongestion would diminish the signal for harm associated with WRF. Methods: We performed a systematic search of PubMed, EMBASE, and the Cochrane Library up to December 2019 for studies that assessed signs of decongestion in patients with WRF during ADHF admission...
September 2020: KI Reports
https://read.qxmd.com/read/32255557/cohort-study-with-patients-older-than-80-years-with-stage-5-chronic-kidney-failure-on-hemodialysis-vs-conservative-treatment-survival-outcomes-and-use-of-healthcare-resources
#15
JOURNAL ARTICLE
Alicia García Testal, Rafael García Maset, Victoria Fornés Ferrer, Antonio J Cañada Martínez, Sonia Fernández Fandos, Inmaculada S Rico Salvador, Pilar Royo Maicas, Vanesa Carretero López, Javier Villalón Coca, Jose E Fernández Najera, Caterina Benedito Carrera, Pau Olagüe Díaz, Eduardo Torregrosa De Juan
Renal replacement treatment has not been generalized to the elderly for different reasons. The main objective of the present cohort study is to compare survival in patients older than 80 years with chronic kidney disease stage 5 on renal replacement treatment with those on conservative treatment. The use of healthcare resources is compared too. A Cox proportional hazards regression analysis was run with the outcome variable death during the follow-up period. The independent variables were treatment type, age, gender, smoking habit, serum albumin, hemoglobin, Charlson Index, diabetes mellitus, arterial hypertension, ischemic cardiopathy, and neoplasm...
February 2021: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/31768917/synthesizing-markers-of-kidney-injury-in-acute-decompensated-heart-failure-should-we-even-keep-looking
#16
REVIEW
Alexander S Manguba, Xavier Vela Parada, Steven G Coca, Anuradha Lala
PURPOSE OF REVIEW: This review discusses evidence that has accumulated over the years on the diagnostic and prognostic utility of biomarkers of kidney injury in the setting of acute decompensated heart failure. RECENT FINDINGS: Despite numerous studies evaluating several different biomarkers both in the serum and urine, the current body of evidence does not support routine use of any of these biomarkers for the purposes of diagnosis of acute kidney injury or for prognosis after hospitalization for acute decompensated heart failure...
December 2019: Current Heart Failure Reports
https://read.qxmd.com/read/30418172/a-protective-role-for-microrna-688-in-acute-kidney-injury
#17
COMMENT
Nicholas Chun, Steven G Coca, John Cijiang He
Ischemia-reperfusion (I/R) sets off a devastating cascade of events, leading to cell death and possible organ failure. Treatments to limit I/R-associated damage are lacking, and the pathways that drive injury are poorly understood. In this issue of the JCI, Wei and colleagues identify microRNA-668 (miR-668) as a protective factor in acute kidney injury (AKI). miR-668 was shown to repress mitochondrial fission-associated protein MTP18, thereby inhibiting pathogenic mitochondrial fragmentation. In murine models of I/R-induced AKI, treatment with a miR-668 mimetic reduced mitochondrial fragmentation and improved renal function...
December 3, 2018: Journal of Clinical Investigation
https://read.qxmd.com/read/29652731/obesity-and-cardiovascular-risk-a-call-for-action-from-the-european-society-of-hypertension-working-group-of-obesity-diabetes-and-the-high-risk-patient-and-european-association-for-the-study-of-obesity-part-b-obesity-induced-cardiovascular-disease-early-prevention
#18
JOURNAL ARTICLE
Vasilios Kotsis, Konstantinos Tsioufis, Christina Antza, Gino Seravalle, Antonio Coca, Cristina Sierra, Empar Lurbe, Stella Stabouli, Bojan Jelakovic, Josep Redon, Pau Redon, Peter M Nilsson, Jens Jordan, Dragan Micic, Nicholas Finer, Deborah R Leitner, Hermann Toplak, Lale Tokgozoglu, Vasilios Athyros, Moses Elisaf, Theodosios D Filippatos, Guido Grassi
: Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications...
July 2018: Journal of Hypertension
https://read.qxmd.com/read/29582960/-acute-kidney-injury-and-rhabdomyolysis-after-cocaine-overdose-case-report-and-literature-review
#19
REVIEW
Anna Mudoni, Francesco Caccetta, Maurizio Caroppo, Fernando Musio, Antonella Accogli, Maria Dolores Zacheo, Maria Domenica Burzo, Vitale Nuzzo
Cocaine, a natural alkaloid derived from the coca plant, is one of the most commonly used illicit drugs. Cocaine abuse causes systemic adverse effects like stroke, myocardic infarction, arterial dissection, vascular thrombosis and rhabdomyolysis. Cocaine use is, also, associated with renal complications such as acute kidney injury, vasculitis, acute interstitial nephritis, chronic kidney disease, malignant hypertension with thrombotic microangiopathy. Acute kidney injury may or may be not associated to rhabdomyolysis...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/29352071/worsening-renal-function-in-patients-with-acute-heart-failure-undergoing-aggressive-diuresis-is-not-associated-with-tubular-injury
#20
RANDOMIZED CONTROLLED TRIAL
Tariq Ahmad, Keyanna Jackson, Veena S Rao, W H Wilson Tang, Meredith A Brisco-Bacik, Horng H Chen, G Michael Felker, Adrian F Hernandez, Christopher M O'Connor, Venkata S Sabbisetti, Joseph V Bonventre, F Perry Wilson, Steven G Coca, Jeffrey M Testani
BACKGROUND: Worsening renal function (WRF) in the setting of aggressive diuresis for acute heart failure treatment may reflect renal tubular injury or simply indicate a hemodynamic or functional change in glomerular filtration. Well-validated tubular injury biomarkers, N -acetyl-β-d-glucosaminidase, neutrophil gelatinase-associated lipocalin, and kidney injury molecule 1, are now available that can quantify the degree of renal tubular injury. The ROSE-AHF trial (Renal Optimization Strategies Evaluation-Acute Heart Failure) provides an experimental platform for the study of mechanisms of WRF during aggressive diuresis for acute heart failure because the ROSE-AHF protocol dictated high-dose loop diuretic therapy in all patients...
May 8, 2018: Circulation
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