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amphetamine and renal failure

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https://www.readbyqxmd.com/read/27358538/acute-myocardial-infarction-with-multiple-coronary-thromboses-in-a-young-addict-of-amphetamines-and-benzodiazepines
#1
Mohammed A Al Shehri, Ali A Youssef
A 35-year-old man of average build and a smoker, with a background of a psychiatric disorder, was brought by his neighbor to the emergency department after an hour of severe chest pain. Upon arrival at the hospital he had cardiac arrest, was resuscitated, and moved to the catheterization laboratory with inferior, posterior, and lateral myocardial infarction. Coronary angiography showed an unusual thrombosis in multiple coronary branches. Toxicology report showed high levels of amphetamines and benzodiazepines in the patient's original blood sample...
July 2016: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/25588018/novel-psychoactive-substances-designer-drugs-overview-and-pharmacology-of-modulators-of-monoamine-signaling
#2
REVIEW
Matthias Liechti
Novel psychoactive substances are newly used designer drugs ("internet drugs", "research chemicals", "legal highs") potentially posing similar health risks to classic illicit substances. Chemically, many novel psychoactive substances can be classified as phenethylamines, amphetamines, synthetic cathinones, piperazines, pipradrols/piperidines, aminoindanes benzofurans, and tryptamines. Pharmacologically, these substances interact with various monoaminergic targets. Typically, stimulants inhibit the transport of dopamine and noradrenaline (pipradrols, pyrovalerone cathinones) or induce the release of these monoamines (amphetamines and methamphetamine-like cathinones), entactogens predominantly enhance serotonin release (phenylpiperazines, aminoindanes, para-substituted amphetamines, and MDMA-like cathinones) similar to MDMA (ecstasy), and hallucinogens (tryptamines, hallucinogenic phenethylamines) are direct agonists at serotonergic 5-HT2A receptors...
2015: Swiss Medical Weekly
https://www.readbyqxmd.com/read/25060403/acute-methoxetamine-and-amphetamine-poisoning-with-fatal-outcome-a-case-report
#3
Marek Wiergowski, Jacek Sein Anand, Maciej Krzyżanowski, Zbigniew Jankowski
Methoxetamine (MXE) is a psychoactive substance distributed mostly via the Internet and is not liable to legal regulation in Poland. MXE has a toxicity profile similar to that of ketamine but longer-lasting effects. The paper describes a case of acute poisoning that resulted from recreational use of MXE and amphetamine and ended in death. In mid-July 2012, a 31-year old man was admitted to the clinical toxicology unit in Gdańsk because of poisoning with an unknown psychoactive substance. The patient was transported to the emergency department (ED) at 5:15 a...
August 2014: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/24600729/drug-related-cardiac-valve-disease
#4
REVIEW
(no author information available yet)
Cardiac valve disease can involve one or more of the four heart valves. Chronic valve damage may remain asymptomatic for long periods but ultimately leads to haemodynamic overload of the heart. The most common causes of valve disease are rheumatic diseases, infections, chronic renal failure, malformations, and genetic diseases. Valve disease is often attributed to degeneration with no known cause.The frequency of drug-related valve disease has long been underestimated. Most implicated drugs have serotonergic properties, such as fenfluramine-derived amphetamines, including benfluorex...
December 2013: Prescrire International
https://www.readbyqxmd.com/read/24356039/sympathomimetic-syndrome-choreoathetosis-and-acute-kidney-injury-following-bath-salts-injection
#5
Grerk Sutamtewagul, Vineeta Sood, Kenneth Nugent
"Bath salts" is a well known street drug which can cause several cardiovascular and neuropsychiatric symptoms. However, only one case of acute kidney injury has been reported in the literature. We present a case with sympathomimetic syndrome, choreoathetosis, gustatory and olfactory hallucinations, and acute kidney injury following the use of bath salts. A 37-year-old man with past medical history of hypertension and depression was brought to the emergency center with body shaking. Three days before admission he injected 3 doses of bath salts intravenously and felt eye pain with blurry vision followed by a metallic taste, strange smells, profuse sweating, and body shaking...
January 2014: Clinical Nephrology
https://www.readbyqxmd.com/read/24229483/methamphetamine-addiction-and-medical-futility
#6
Ruchika Mishra
No abstract text is available yet for this article.
October 2013: Cambridge Quarterly of Healthcare Ethics: CQ: the International Journal of Healthcare Ethics Committees
https://www.readbyqxmd.com/read/24090944/liver-abnormalities-in-drug-and-substance-abusers
#7
REVIEW
Puraskar Pateria, Bastiaan de Boer, Gerry MacQuillan
Drug and substance abuse remains a major medical problem. Alcohol use, abuse and dependence are highly prevalent conditions. Alcohol related liver disease can present as simple steatosis, steatohepatitis, alcoholic hepatitis or liver cirrhosis. Paracetamol hepatotoxicity secondary to accidental or deliberate overdose is another common problem. While the adverse cardiovascular, neurological, renal and psychiatric consequences of various illicit substance abuses are widely studied and publicized, less attention has been directed towards possible hepatotoxic effects...
August 2013: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/22430552/-dialysis-for-severe-rhabdomyolysis-7-days-after-multiple-trauma
#8
A Malin, J Freyhoff, W Nobis, H G Bone
A case report of severe rhabdomyolysis in a 33-year-old motorcyclist after multiple trauma is described. The injuries included severe thoracic and abdominal trauma as well as injuries to the extremities and spinal column. During the first 3 days of treatment a forced volume therapy was performed because of increased levels of creatine kinase during which the patients condition stabilized both hemodynamically and respiratorily. On day 10 the patient developed a rise in temperature to 42°C with no evidence of a re-infection and the creatine kinase levels rose to 109,830 U/l...
March 2012: Der Anaesthesist
https://www.readbyqxmd.com/read/17326279/adverse-drug-reactions-during-heatwaves
#9
(no author information available yet)
Patients receiving the following drugs should be closely monitored during heatwaves: psychotropics, atropinics, amphetamine-like drugs, parasympathomimetic agents such as cholinesterase inhibitors, thyroid hormones, drugs that increase the risk of renal failure in case of dehydration, and betablockers.
February 2007: Prescrire International
https://www.readbyqxmd.com/read/17288036/-loss-of-weight-and-acute-abdominal-pain-in-a-38-year-old-psychostimulant-abuser
#10
Tor-Bjarne Nymark, Hedda Soløy-Nilsen, Rolf Steen, Erik Waage Nielsen
MATERIAL AND METHODS: A 38-year-old psychostimulant abuser was admitted to hospital after syncope. He had lost much of his weight over the last 6 months, had abdominal pain the last 10 days and bloody diarrhoea and hypotension upon admittance. The abdomen was soft and non-tender. Due to renal failure and metabolic acidosis with base excess of -16 to -22 mmol/L and lactate from 9.5 to 16 mmol/L, haemodialysis was given twice. Acidosis worsened. He suffered from respiratory arrest twice and was resuscitated once before a laparotomy 30 hours after admittance revealed total ischemia of the bowels...
February 1, 2007: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/16357628/non-alcoholic-fatty-liver-disease-in-hiv-positive-patients-predisposes-for-acute-on-chronic-liver-failure-two-cases
#11
Alisan Kahraman, Michael Miller, Robert K Gieseler, Guido Gerken, Michael J Scolaro, Ali Canbay
Non-alcoholic fatty liver disease is a prominent feature in HIV-positive patients. We present two patients with long-lasting HIV-infection who suffered from this disease, as induced by highly active anti-retroviral therapy (HAART). The patients developed acute-on-chronic (AOC) liver failure after either (case 1) acute infection with hepatitis A virus (HAV) or (case 2) methamphetamine abuse ('Ecstasy'). Approximately 1 week after visiting an area endemic for HAV, case 1, a male patient, presented with icterus, elevated liver transaminases and HAV IgM...
January 2006: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/16161930/-rhabdomyolysis-disseminated-intravascular-coagulation-and-acute-renal-failure-after-severe-narcotics-intoxication-mdma-thc-amphetamine
#12
Anna Kunsdorf-Wnuk, Ewa Musioł, Ewa Karpel, Danuta Arct-Danielak
More often we are faced with the cases of young people (who are in a serious condition) who land in ICU, because of severe narcotics intoxication, which they took occasionally on the concerts, discotheques and social events. From 1997 we observed rapid increase of admission to hospitals due to amphetamine, MDMA (2,3-methylenedeoxymethamphetamine which is a main component of a tablet called ecstasy) and THC (9-d tetrahydrocannabinols which are a component of sunn hemps) intoxication and decrease of opioid's poisoning...
April 2005: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/16088595/amphetamine-toxicity
#13
Suzanne R White
Amphetamine abuse is widespread and associated with significant health risk. The most commonly encountered amphetamines are methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), and the ephedra alkaloids. Although each of these harbors unique toxicity, they similarly impact the cardiovascular and neurological systems in overdose. Other serious complications associated with amphetamine abuse include severe hyperpyrexia and hyponatremia. Secondary conditions such as rhabdomyolysis, disseminated intravascular coagulation (DIC), gastrointestinal (GI) bleeding, hepatic necrosis, and renal failure are common, especially in those with hyperthermia...
February 2002: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/15916245/measurement-of-3-4-mdma-and-related-amines-in-diagnostic-and-forensic-laboratories
#14
REVIEW
Victor A Skrinska, Susan B Gock
The phenylalkylamine derivatives, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy, XTC, Adam), 3,4-methylenedioxyethamphetamine (MDEA, MDE, Eve), and 3,4-methylenedioxyamphetamine (MDA), are psychostimulants with hallucinogenic properties. MDA is also a metabolite of both MDMA and MDEA. These drugs are ring-substituted amphetamine derivatives that produce hallucinogenic, entactogenic ('love drug'), and stimulating effects. MDMA was initially developed as an appetite suppressant, however, its use as a therapeutic drug has been very limited...
2005: Clinical Laboratory Science: Journal of the American Society for Medical Technology
https://www.readbyqxmd.com/read/15860966/gynecomastia-and-hypertension
#15
REVIEW
L Michael Prisant, Edward Chin
Palpable dense and mobile subareolar tissue in the male breast defines the presence of gynecomastia. For the hypertension specialist, breast enlargement in men provides a clue to a secondary cause of hypertension or an adverse antihypertensive drug reaction. Hyperthyroidism, chronic renal failure, adrenal hyperplasia or tumors, amphetamine, cyclosporine, and anabolic steroids are secondary causes of hypertension associated with gynecomastia. Reserpine, methyldopa, and spironolactone are older drugs associated with gynecomastia; however, calcium antagonists (more commonly), angiotensin-converting enzyme inhibitors, and alpha1 blockers may also be associated with this finding...
April 2005: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/15521617/-clinical-and-toxicological-evaluation-of-fatal-poisoning-with-amphetamine-derivative-mdma-ecstasy-3-4-methylenedioxymethamphetamine
#16
Magdalena Lukasik-Głebocka, Roman Wachowiak, Andrzej Kostrzewa, Michał Karlikowski, Wojciech Mańkowski, Janusz Kołowski
Intoxications with amphetamine derivatives represent an important problem of clinical and forensic toxicology. Even if distribution of the drug group has been legally forbidden, they continue to pose serious threats, linked to their uncontrolled administration which frequently leads to lethal intoxications. We present a case of intoxication in a 17-year-old male with amphetamine derivate--MDMA, Ecstasy. Clinical analysis documented an acute multi-organ failure, in particular pronounced hepatic and renal insufficiency, disseminated intravascular clotting (DIC)...
2004: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/12935649/immunohistochemical-study-of-myoglobin-and-oxidative-injury-related-markers-in-the-kidney-of-methamphetamine-abusers
#17
COMPARATIVE STUDY
Akiko Ishigami, Itsuo Tokunaga, Takako Gotohda, Shin-ichi Kubo
It is known that methamphetamine (MA) causes rhabdomyolysis, myoglobinuria, and acute renal failure. We conducted an immunohistochemical study on the kidney of 22 forensic autopsy cases in which MA had been detected. Myoglobin was positive in 17 cases. The concentration of the blood MA in the myoglobin-positive cases (8.39+/-3.43 micromol/dl) was higher than -negative cases (0.198+/-0.076 micromol/dl). And, the 70 kDa heat shock protein (HSP70), 8-hydroxy-2'-deoxyguanosine (8-OH-dG), 4-hydroxy-2-nonenal (4-HNE), and Cu/Zn superoxide dismutase (SOD) were also stained positively in five, ten, 11, nine cases of examined, respectively...
March 2003: Legal Medicine
https://www.readbyqxmd.com/read/12361531/-variability-of-the-clinical-expression-of-ecstasy-induced-hepatotoxicity
#18
COMPARATIVE STUDY
O Núñez, R Bañares, J Barrio, L Menchén, A de Diego, E Salinero, G Clemente
3,4-methylenedioxymethamphetamine (MDMA) is an amphetamine derivative, known as ecstasy. Because of its euphoric effects, the use of this substance as a drug of abuse is becoming increasingly widespread. The development of hyperthermia, disseminated intravascular coagulation, rhabdomyolysis, acute renal failure, cardiac arrhythmia and neurotoxicity have been described in association with the use of this drug. Moreover, in the last few years, cases of liver involvement, associated or not with the above-mentioned entities, have been described, ranging from mild acute hepatitis to fulminant hepatic failure and death...
October 2002: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/12166551/upper-airway-obstruction-and-acute-lung-injury-associated-with-cocaine-abuse
#19
S Raza Ali, M Krugar, J Houghton
We describe the case of a 14-year-old boy who developed airway obstruction due to acute upper respiratory tract infection. Following emergency tracheostomy, he developed pulmonary oedema and required ventilation. The postoperative course was complicated by the development of adult respiratory distress syndrome, characterised by marked respiratory distress, diffuse pulmonary infiltrates on chest radiography, reduced pulmonary compliance and marked increase in alveolar-arterial oxygen difference. He also developed persistent high-grade pyrexia, renal failure and cardiac instability...
July 2002: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/11975400/-adverse-renal-effects-of-legal-and-illicit-drugs
#20
REVIEW
S R Orth
The most important task of clinical and experimental nephrology is to identify risk factors for progression of renal failure with the ultimate goal to counteract the dramatic increase of patients reaching end-stage renal disease. Recently, cigarette smoking has been recognized to be one of the most important remediable renal risk factors. The adverse renal effects of smoking seem to be independent of the underlying renal disease and the current evidence suggests a near doubling of the rate of progression in smokers vs...
March 2002: Therapeutische Umschau. Revue Thérapeutique
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