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BUN, creatinine ratio

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https://www.readbyqxmd.com/read/27932336/heat-stress-hydration-and-uric-acid-a-cross-sectional-study-in-workers-of-three-occupations-in-a-hotspot-of-mesoamerican-nephropathy-in-nicaragua
#1
Catharina Wesseling, Aurora Aragón, Marvin González, Ilana Weiss, Jason Glaser, Christopher J Rivard, Carlos Roncal-Jiménez, Ricardo Correa-Rotter, Richard J Johnson
OBJECTIVES: To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. DESIGN: Cross-sectional. SETTING: Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January-February 2013. PARTICIPANTS: 194 male workers aged 17-39 years: 86 sugarcane cutters, 56 construction workers, 52 small-scale farmers. OUTCOME MEASURES: (1) Differences between the three occupational groups in prevalences/levels of socioeconomic, occupational, lifestyle and health risk factors for chronic kidney disease (CKD) and in biomarkers of kidney function and hydration; (2) differences in prevalences/levels of CKD risk factors between workers with reduced estimated glomerular filtration rate (eGFRCKD-EPI <80 mL/min/1...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27846769/effect-of-cichorium-intybus-l-seed-extract-on-renal-parameters-in-experimentally-induced-early-and-late-diabetes-type-2-in-rats
#2
Yasin Pourfarjam, Lotfollah Rezagholizadeh, Azin Nowrouzi, Alipasha Meysamie, Sarah Ghaseminejad, Nasrin Ziamajidi, Davood Norouzi
Blood and urine biochemistry screening tests are important for initial detection of diabetes, determination of severity of its complications, and monitoring of therapy. We evaluated the effects of aqueous chicory seed extract (CSE), on renal biochemical parameters, histology, and Na+/glucose cotansporters, SGLT1 and SGLT2 expression levels using metformin, and aspirin as controls. Late stage type 2 diabetes (LT2D; FBS, >300 mg/dl) and early stage type 2 diabetes (ET2D; FBS, 140-220 mg/dl) were induced in rats by streptozotocin (STZ group) and a combination of STZ and niacinamide (NIA/STZ group), respectively...
November 16, 2016: Renal Failure
https://www.readbyqxmd.com/read/27818782/randomized-pilot-trial-comparing-tolvaptan-with-furosemide-on-renal-and-neurohumoral-effects-in-acute-heart-failure
#3
Kentaro Jujo, Katsumi Saito, Issei Ishida, Yuho Furuki, Ahsung Kim, Yuki Suzuki, Haruki Sekiguchi, Junichi Yamaguchi, Hiroshi Ogawa, Nobuhisa Hagiwara
AIMS: Loop diuretics are first-line medications for congestive heart failure (CHF); however, they are associated with serious adverse effects, including decreased renal function, and sympathetic nervous and renin-angiotensin system activation. We tested whether tolvaptan, a vasopressin V2-receptor antagonist, could reduce unfavourable furosemide-induced effects during CHF treatment. METHODS AND RESULTS: Sixty patients emergently hospitalized owing to CHF-induced dyspnea were randomly assigned to receive either 40 mg intravenous furosemide daily or 7...
September 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27801770/dehydration-status-is-associated-with-more-severe-hemispatial-neglect-after-stroke
#4
Mona N Bahouth, Zainab Bahrainwala, Argye E Hillis, Rebecca F Gottesman
BACKGROUND: Many stroke patients are clinically dehydrated at the time of hospital presentation, which could lead to an increase in blood viscosity and alteration in cerebral perfusion. Impaired cerebral perfusion can cause hemispheric dysfunction, which can be rapidly quantified with bedside tests of hemispatial neglect. We hypothesized that hospitalized patients with laboratory markers consistent with dehydration or a volume contracted state (VCS) would have more severe cerebral dysfunction defined by greater degree of neglect...
November 2016: Neurologist
https://www.readbyqxmd.com/read/27796167/in-vivo-toxicity-assessment-of-deoxynivalenol-contaminated-wheat-after-ozone-degradation
#5
Li Wang, Ying Wang, Huili Shao, Xiaohu Luo, Ren Wang, Yongfu Li, Yanan Li, Yingpeng Luo, Dongjie Zhang, Zhengxing Chen
The effect of ozone on deoxynivalenol (DON) detoxification was investigated. Ozone treatment could significantly reduce the levels of DON in wheat; 53% of DON in wheat was decomposed with 90 mg/L of ozone at a flow rate of 15 L/min for 4 h. The safety of deoxynivalenol-contaminated wheats (DCWs) untreated/treated by ozone was also evaluated. ICR mice were divided into a standard diet group and five experimental diet groups for a 51-day orally administration experiment. In the 51-day administration experiment, no remarkable changes in the general appearance of the mice were observed, and all of the mice survived until the scheduled necropsy...
October 31, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27750234/clinical-factors-predicting-the-effect-of-tolvaptan-for-refractory-ascites-in-patients-with-decompensated-liver-cirrhosis
#6
Hirokazu Chishina, Satoru Hagiwara, Naoshi Nishida, Kazuomi Ueshima, Toshiharu Sakurai, Hiroshi Ida, Yasunori Minami, Masahiro Takita, Masashi Kono, Tomohiro Minami, Mina Iwanishi, Yasuko Umehara, Tomohiro Watanabe, Yoriaki Komeda, Tadaaki Arizumi, Masotoshi Kudo
OBJECTIVE: Refractory ascites reduces the quality of life of liver cirrhosis patients. Albumin preparation and diuretics, such as furosemide, have been used to treat refractory ascites, but the effect was poor in many patients. In this study, we analyzed patients treated with tolvaptan (TLV) at our hospital and investigated predictors of the effect. METHODS: The subjects were 70 patients for whom TLV was introduced to treat refractory ascites who could be analyzed between November 2013 and March 2015 at our hospital...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27717719/favorable-outcome-of-blood-urea-nitrogen-creatinine-based-hydration-therapy-3-months-after-acute-ischemic-stroke
#7
Chung Jen Lin, Jen Tsung Yang, Yen Chu Huang, Yuan Hsiung Tsai, Ming Hsueh Lee, Meng Lee, Cheng Ting Hsiao, Kuang Yu Hsiao, Leng Chieh Lin
BACKGROUND: Dehydration is associated with acute ischemic stroke. However, the relationship between hydration therapy given during acute ischemic stroke and clinical outcomes remains unclear. AIMS: We determined whether hydration therapy in patients with a blood urea nitrogen/creatinine (BUN/Cr) ratio of at least 15 improved clinical outcome. METHODS: We conducted a nonblinded, phase II, single-arm, prospective study of patients with acute ischemic stroke and BUN/Cr ratio of at least 15 with historical controls...
September 17, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27697932/effects-of-dietary-recombinant-chlorella-supplementation-on-growth-performance-meat-quality-blood-characteristics-excreta-microflora-and-nutrient-digestibility-in-broilers
#8
H Choi, S K Jung, J S Kim, K-W Kim, K B Oh, P-Y Lee, S J Byun
The use of chlorella as an immune stimulant to enhance nonspecific host defense mechanisms or as an antimicrobial to inhibit bacterial growth has been reported. Thus, the aim of the present study was to clarify the effect of recombinant chlorella supplementation on growth performance, meat quality, and the blood profile, excreta microflora, and nutrient digestibility in broilers. A total of 375 one-day-old ROSS 308 broilers (male and female) were allotted to 5 dietary treatments using 5 cages with 15 chicks per cage...
October 2, 2016: Poultry Science
https://www.readbyqxmd.com/read/27670393/the-response-to-tolvaptan-and-its-effect-on-prognosis-in-cirrhotic-patients-with-ascites
#9
Tomomi Kogiso, Kuniko Yamamoto, Mutsuki Kobayashi, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Etsuko Hashimoto, Katsutoshi Tokushige
AIMS: The vasopressin V2 receptor antagonist tolvaptan has been used for the treatment of cirrhotic patients with ascites; however, no predictor of efficacy and prognosis has been developed. Here, we evaluated candidate predictors of response to tolvaptan treatment. METHODS: This was a single-center retrospective study. Overall, 97 Japanese cirrhotic patients (60 males, median age 63 years), who were hospitalized for ascites treatment including oral tolvaptan coupled with conventional diuretics, were enrolled...
September 27, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27665012/biodetoxification-of-aflatoxin-b1-in-cottonseed-meal-by-fermentation-of-cellulosimicrobium-funkei-in-duckling-diet
#10
J Liu, W-J Song, N-Y Zhang, J Tan, C S Krumm, L-H Sun, D-S Qi
Two experiments were conducted to optimize the fermentation of cottonseed meal by Cellulosimicrobium funkei (C. funkei) for the ability of the bacteria to degrade aflatoxin B1 (AFB1) and then to evaluate the bacterial detoxification in ducklings. In experiment 1, the fermentation of cottonseed meal by C. funkei was improved by changing the inoculation amounts by 10% (10(8) cfu/mL), using a 1:0.5 material to water ratio at 35°C temperature for a 144 h reaction duration, which resulted in an 83.4% biodegradation of AFB1...
September 24, 2016: Poultry Science
https://www.readbyqxmd.com/read/27658757/blood-urea-nitrogen-to-creatinine-ratio-in-the-general-population-and-in-patients-with-acute-heart-failure
#11
Yuya Matsue, Peter van der Meer, Kevin Damman, Marco Metra, Christopher M O'Connor, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G Cleland, Michael M Givertz, Daniel M Bloomfield, Howard C Dittrich, Ron T Gansevoort, Stephan J L Bakker, Pim van der Harst, Hans L Hillege, Dirk J van Veldhuisen, Adriaan A Voors
OBJECTIVE: The blood urea nitrogen-to-creatinine (BUN/creatinine) ratio has been proposed as a useful parameter in acute heart failure (AHF), but data on the normal range and the added value of the ratio compared with its separate components in patients with AHF are lacking. The aim of this study is to define the normal range of BUN/creatinine ratio and to investigate its clinical significance in patients with AHF. METHODS: In 4484 subjects from the general population without cardiovascular comorbidities, we calculated age-specific and sex-specific normal values of the BUN/creatinine ratio, deriving a higher and lower than normal range of BUN/creatinine ratio (exceeding the 95% prediction intervals)...
September 22, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27650550/low-glomerular-filtration-rate-as-an-associated-risk-factor-for-sarcopenic-muscle-strength-is-creatinine-or-cystatin-c-based-estimation-more-relevant
#12
Asli Tufan, Fatih Tufan, Timur Selcuk Akpinar, Birkan Ilhan, Gulistan Bahat, Mehmet Akif Karan
INTRODUCTION: We aimed to evaluate the association of a decreased glomerular-filtration-rate (GFR <60 ml/min/1.73 m(2)), estimated using Modification of Diet in Renal Disease (MDRD), creatinine- and cystatin C-based (CKDEPI-CR and CKDEPI-CC) Chronic Kidney Disease Epidemiology Collaboration equations with handgrip strength (HGS). METHODS: Community-dwelling males aged ≥60 years admitted to outpatient clinic were included. We used MDRD, CKDEPI-CR, and CKDEPI-CC formulas for GFR estimation and corrected these for body surface area...
September 20, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#13
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27635166/accuracy-of-the-caval-index-and-the-expiratory-diameter-of-the-inferior-vena-cava-for-the-diagnosis-of-dehydration-in-elderly
#14
Daniele Orso, Nicola Guglielmo, Nicola Federici, Francesco Cugini, Alessio Ban, Filippo Mearelli, Roberto Copetti
PURPOSE: Dehydration is a very common condition among elderly people. Till date there is not yet a fast and easy method to determine a state of dehydration in the emergency department. In the literature there are some exploratory studies that have tried to establish the relationship between some widely used laboratory values and ultrasound for the purpose of diagnosing dehydration. The primary aim of this study is to verify the correlation between two measures derived by ultrasound (caval index and expiratory diameter of inferior vena cava) and blood urea nitrogen (BUN)/creatinine ratio...
September 2016: Journal of Ultrasound
https://www.readbyqxmd.com/read/27608635/nutrient-intake-digestibility-and-performance-of-gaddi-kids-supplemented-with-tea-seed-or-tea-seed-saponin-extract
#15
Manjeet Kumar, Alagarsamy Kannan, Rasbehari Bhar, Ashu Gulati, Alok Gaurav, Vijay Kumar Sharma
The present study determined the nutrient intake, digestibility, nitrogen balance, microbial protein synthesis, haemato-biochemical attributes, immune response and growth performance of Gaddi kids fed with oat fodder based basal diet supplemented with either tea seed or tea seed saponin extract. Eighteen male kids, 7.03 ± 0.16 months of age and 19.72 ± 0.64 kg body weight (BW) , were distributed into three groups, T0 (control), T1 and T2, consisting of 6 animals each in a completely randomised design. The kids were fed a basal diet consisting of concentrate mixture and oat fodder (50:50) to meet the maintenance requirement and for growth rate of 40 g/day...
September 9, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27583657/does-hypoxis-hemerocallidea-mitigate-renal-histopathological-injuries-following-highly-active-antiretroviral-therapy-an-experimental-animal-study
#16
Ugochukwu Offor, Ayoola I Jegede, Ismail O Onanuga, Edwin C Naidu, Onyemaechi O Azu
BACKGROUND: Nephrotoxicity has become an important public health problem following the success recorded with highly active antiretroviral therapy and there is paucity of literature reporting the attenuating influence of plant-based adjuvants that can mitigate the effects. METHODS: Sixty three adult male Sprague-Dawley rats were divided into 9 groups (A-I) and treated as follows; Group A received HAART cocktail (Lamivudine, Stavudine & Nevirapine), Group B received HAART and Hypoxis hemerocallidea (HH) extract (200mg/kg), Group C received HAART and HH (100mg/kg), Group D received HAART and vitamin C, Group E received HAART and vitamin E, Group F received HAART, vitamin C and vitamin E, Group G received HH extract (100mg/kg), Group H received HH extract (200mg/kg), and Group I received saline as placebo...
September 1, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27558026/clinical-and-pathological-analysis-of-iga-nephropathy-with-chronic-renal-failure
#17
Yuyuan Liu, Qinfeng Hu, Ping Shen, Li Tang, Gang Yuan, Yongmei Zhou, Huaqi Chai
OBJECTIVE: To investigative clinical and pathological characteristics of IgA nephropathy with chronic renal failure. METHOD: Clinical and pathological findings from 65 cases of IgA nephropathy with chronic renal failure were reviewed. Pathological characteristics of all the cases were analyzed according to WHO definition and Oxford Classification. Evaluating the severity of pathological lesions by the Katafuchi R semiquantitative scoring system, and analyzing their relationship with clinical indexes of renal function...
August 25, 2016: Renal Failure
https://www.readbyqxmd.com/read/27552825/serum-potassium-profile-and-associated-factors-in-incident-peritoneal-dialysis-patients
#18
Ying Liu, Ben-Chung Cheng, Wen-Chin Lee, Lung-Chih Li, Chih-Hsiung Lee, Wen Xiu Chang, Jin-Bor Chen
BACKGROUND/AIMS: Abnormal potassium profiles are common in peritoneal dialysis (PD) patients. We studied the factors associated with serum potassium profiles in incident PD patients. METHODS: Patients were enrolled from two hospital-facilitated PD centers from May 2013 to May 2016 and January 2009 to December 2015. A total of 319 incident PD patients were examined for factors associated with serum potassium profile. Average serum potassium levels were obtained for analysis during the first 3 months after PD initiation...
August 24, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27540513/the-effect-of-renal-diet-in-association-with-enalapril-or-benazepril-on-proteinuria-in-dogs-with-proteinuric-chronic-kidney-disease
#19
A Zatelli, X Roura, P D'Ippolito, M Berlanda, E Zini
Treating proteinuria in dogs reduces the progression of chronic kidney disease (CKD); renal diets and angiotensin-converting enzyme (ACE)-inhibitors are cornerstones of treatment. Whether different ACE-inhibitors have distinct kidney protective effects is unknown; it is therefore hypothesized that renal diets and enalapril or benazepril have different beneficial effects in proteinuric CKD dogs. Forty-four dogs with proteinuric CKD (IRIS stages 1-4) were enrolled in the study and were fed renal diet for 30 days...
2016: Open veterinary journal
https://www.readbyqxmd.com/read/27539963/adipocytes-play-an-etiological-role-in-the-podocytopathy-of-high-fat-diet-fed-rats
#20
Jinn-Yang Chen, Deng-Yuan Jian, Chih-Chan Lien, Yu-Ting Lin, Ching-Heng Ting, Luen-Kui Chen, Ting-Chia Hsu, Hsuan-Min Huang, Yu-Ting Wu, Tse-Ting Kuan, Yu-Wen Chao, Liang-Yi Wu, Seng-Wong Huang, Chi-Chang Juan
Obesity is a risk factor that promotes progressive kidney disease. Studies have shown that an adipocytokine imbalance contributes to impaired renal function in humans and animals, but the underlying interplay between adipocytokines and renal injury remains to be elucidated. We aimed to investigate the mechanisms linking obesity to chronic kidney disease. We assessed renal function in high-fat diet (HF)-fed and normal diet-fed rats, and the effects of preadipocyte- and adipocyte-conditioned medium on cultured podocytes...
August 18, 2016: Journal of Endocrinology
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