keyword
https://read.qxmd.com/read/38535116/short-term-mortality-in-hospitalized-patients-with-congestive-heart-failure-markers-of-thrombo-inflammation-are-independent-risk-factors-and-only-weakly-associated-with-renal-insufficiency-and-co-morbidity-burden
#1
JOURNAL ARTICLE
Jose Iglesias, Nelson Okoh, Song Peng Ang, Cristina A Rodriguez, Jia Ee Chia, Jerrold S Levine
Congestive heart failure (CHF) is associated with significant morbidity and mortality. There has been renewed interest in using thrombo-inflammatory markers as prognostic tools in patients with CHF. To determine if thrombo-inflammatory markers are independent risk factors for 28-day mortality in hospitalized CHF patients, we retrospectively analyzed admission data extracted from 2008 consecutive patients admitted with a diagnosis of CHF to Zigong Fourth People's Hospital. Multivariate Cox proportional hazards analysis demonstrated that the thrombo-inflammatory markers thrombin time, platelet/lymphocyte ratio (PLR), and D-dimer level were independent predictors of mortality...
March 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38531324/diagnosis-value-of-the-blood-urea-nitrogen-to-creatinine-ratio-in-determining-the-need-for-intervention-of-acute-upper-gastrointestinal-bleeding
#2
JOURNAL ARTICLE
Hong Liu, Yan Li, Chunliang Liu, Zheng Liu, Kailin Chen
INTRODUCTION: The blood urea nitrogen (BUN) to creatinine (Cr) ratio (BUN/Cr ratio) may be used to evaluate the need for intervention of acute upper gastrointestinal bleeding (AUGIB). This study aimed to explore the predictive value of the BUN/Cr ratio in the need for intervention of AUGIB. METHODS: This retrospective observational study included patients with AUGIB in the hospital's emergency department between August 2019 and May 2023. The patients were grouped according to whether they underwent an intervention for AUGIB...
March 26, 2024: Digestive Diseases
https://read.qxmd.com/read/38526065/the-effect-of-the-concurrent-use-of-dexmedetomidine-dex-during-the-perioperative-period-on-the-renal-function-of-patients-following-craniocerebral-interventional-surgery
#3
JOURNAL ARTICLE
Lu Qian, Nianqiang Hu, Yijin Yu
BACKGROUND: Craniocerebral interventional surgery is a common and essential treatment for cerebrovascular diseases. Despite continuous progress in interventional diagnosis and treatment technology, there is no effective method to alleviate contrast-induced kidney injuries. In this retrospective cohort study, we investigated the effect of the concurrent use of Dexmedetomidine (DEX) during the perioperative period on the renal function of patients following craniocerebral interventional surgery...
March 25, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38524741/does-metabolic-syndrome-increase-contrast-induced-nephropathy-in-patients-with-normal-renal-function
#4
JOURNAL ARTICLE
Hasan Shemirani, Ali Hosseini
BACKGROUND: Contrast-induced nephropathy (CIN) is associated with increased mortality and morbidity in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention. This study aimed to compare the incidence of CIN in two groups of patients with and without metabolic syndrome (Mets) with baseline normal renal function. MATERIALS AND METHODS: In this case - control study, 260 patient candidates for CAG, 130 patients with Mets and 130 patients without Mets participated, and their serum creatinine (Cr) level before and the 48 and 72 h after the angiography was measured...
2024: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://read.qxmd.com/read/38516543/the-association-between-dehydration-and-the-prognosis-of-sudden-sensorineural-hearing-loss
#5
JOURNAL ARTICLE
Yasunori Abe, Masahiro Okada, Keiko Tanaka, Kensuke Toyama, Yoshito Miyamoto, Naohito Hato
BACKGROUND: There is an urgent need to identify undetermined risk factors for sudden sensorineural hearing loss (SSNHL) for the development of effective treatment strategies. SSNHL is likely associated with vascular insufficiency; however, no study has evaluated the relationship between dehydration and SSNHL. OBJECTIVE: This study aimed to investigate the role of dehydration in the development and prognosis of sudden sensorineural hearing loss. STUDY DESIGN: Retrospective case-control study...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38510584/which-alarm-symptoms-are-associated-with-abnormal-gastrointestinal-endoscopy-among-thai-children
#6
JOURNAL ARTICLE
Anundorn Wongteerasut
PURPOSE: Alarm symptoms (red flag signs) are crucial indications for management decisions on pediatric gastrointestinal endoscopy. We aimed to identify items in the alarm symptoms and pre-endoscopic investigations that predict abnormal endoscopy results. METHODS: A retrospective descriptive study was conducted among children aged under 18 years undergoing endoscopy. The patients were classified into normal and abnormal endoscopic groups. The incidence of alarm symptoms and pre-endoscopic investigations were compared between the groups...
March 2024: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/38504695/predictive-and-prognostic-potentials-of-lymphocyte-c-reactive-protein-ratio-upon-hospitalization-in-adult-patients-with-acute-pancreatitis
#7
JOURNAL ARTICLE
Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
PURPOSE: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). METHODS: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38497862/preoperative-bmi-and-hb-levels-are-important-predictors-of-massive-bleeding-in-liver-transplant-patients
#8
JOURNAL ARTICLE
K-D Chen, W Chen, B Hu, Z-S Zhao
OBJECTIVE: This study aims to compare intraoperative bleeding during liver transplant procedures and analyze the predictive role of preoperative laboratory indicators in significant intraoperative bleeding. PATIENTS AND METHODS: A retrospective analysis was conducted on 271 cases of allogeneic liver transplant patients from January 2018 to June 2023. Patients were categorized into the massive bleeding (MB) group and the non-massive bleeding (non-MB) group based on the occurrence of significant intraoperative bleeding...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38482553/quantitative-phenotyping-of-nphs1-knockout-mice-as-a-prerequisite-for-gene-replacement-studies
#9
JOURNAL ARTICLE
Florian Buerger, Lea M Merz, Ken Saida, Seyoung Yu, Daanya Salmanullah, Katharina Lemberg, Nils D Mertens, Bshara Mansour, Caroline M Kolvenbach, Kirollos Yousef, Alina Braun, Gijs A C Franken, Nicole Endlich, Ronen Schneider, Shrilee Shril, Friedhelm Hildebrandt
Steroid-resistant nephrotic (SRNS) syndrome is the second most frequent cause of chronic kidney disease before the age of 25 years. Nephrin, encoded by NPHS1, localizes to the slit diaphragm of glomerular podocytes and is the predominant structural component of the glomerular filtration barrier. Biallelic variants in NPHS1 can cause congenital nephrotic syndrome of the Finnish type (CNS-1) for which, to date, no causative therapy is available. Recently, adeno-associated virus (AAV) vectors targeting the glomerular podocyte have been assessed as a means for gene replacement therapy...
March 14, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38481547/effectiveness-of-chinese-herbal-medicine-compared-with-angiotensin-ii-receptor-blockers-in-patients-with-diabetic-kidney-disease-a-hospital-based-matched-cohort-study
#10
JOURNAL ARTICLE
Yuan-Ching Liao, Mei-Yao Wu, Yu-Chuen Huang, Che-Yi Chou, Hung-Rong Yen
Angiotensin II receptor blockers (ARBs) are one of the standard treatments for diabetic kidney disease (DKD). Some patients may opt for Chinese herbal medicine (CHM) of their own free will. However, there is no real-world evidence regarding the effectiveness and safety of CHM. We aimed to explore the effectiveness of CHM for DKD in comparison to ARBs. We enrolled 732 DKD patients (72 used only CHM and 661 used ARBs) from 2007 to 2016, and all patients were followed until December 2016 at China Medical University Hospital in Taiwan...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38454289/audiological-and-vestibular-measurements-in-chronic-renal-failure-patients-receiving-hemodialysis-treatment
#11
JOURNAL ARTICLE
Ahmet Ozmen, Fulya Ozer, Dilek Torun, Hatice Seyra Erbek, Selim Sermed Erbek, Levent Naci Ozluoglu
BACKGROUND: The aim was to evaluate the changes in the audiovestibular system in adult patients with the diagnosis of chronic renal failure who were treated with hemodialysis. METHODS: Thirty-five patients diagnosed with chronic renal failure and receiving hemodialysis treatment 3 days a week and 35 healthy individuals were tested with pure tone audiometry, video head impulse test, and post-head shake nystagmus test. Dizziness Handicap Inventory was applied to all participants...
January 2024: Journal of International Advanced Otology
https://read.qxmd.com/read/38453525/-beclin-1-derived-peptide-mp1-attenuates-renal-fibrosis-by-inhibiting-the-wnt-%C3%AE-catenin-pathway
#12
JOURNAL ARTICLE
Jianfeng Zhang, Xiaocui Feng, Runling Yang, Jingya Bai, Feiyun Gao, Bangzhi Zhang
Renal fibrosis is distinguished by the abnormal deposition of extracellular matrix (ECM) and progressive loss of nephron function, with a lack of effective treatment options in clinical practice. In this study, we discovered that the Beclin-1-derived peptide MP1 significantly inhibits the abnormal expression of fibrosis and Epithelial-mesenchymal transition (EMT)-related markers, including α-Smooth muscle actin (α-SMA), Fibronectin (FN), Collagen I (Col I), Matrix metallopeptidase 2 (MMP2), Snail1, and Vimentin (Vim) both in vitro and in vivo...
March 7, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38453487/diagnostic-performance-of-blood-analytes-for-the-diagnosis-of-renal-disease-in-black-footed-ferrets-mustela-nigripes-at-the-phoenix-zoo-2001-2020
#13
JOURNAL ARTICLE
Alyssa G Palmer, Nicole I Stacy, Jorge A Hernandez, Alexandra Goe
Renal disease is an important cause of morbidity and mortality in managed black-footed ferrets (BFF; Mustela nigripes ).4,6,12 The objectives of this study were to establish reference intervals for blood analytes of clinically normal BFF (1-2 yr old), summarize the frequency of various renal histopathologic findings in a managed population of BFF, assess the diagnostic performance of blood analytes and urine specific gravity (USG) for the diagnosis of renal disease, and assess if comorbidities or age affects the performance of these analytes in diagnosing renal disease...
March 2024: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://read.qxmd.com/read/38442935/-establishment-and-analysis-of-an-early-prognosis-model-of-patients-with-acute-kidney-injury-in-intensive-care-unit
#14
JOURNAL ARTICLE
Yu'an Geng, Congmei Wang, Zhijing Xu, Lu Qi, Yangang Shi, Shiqiong Su, Kai Wang, Ruifang Liu
OBJECTIVE: To establish a predictive model for the progression of acute kidney injury (AKI) to stage 3 AKI (renal failure) in the intensive care unit (ICU), so as to assist physicians to make early and timely decisions on whether to intervene in advance. METHODS: A retrospective analysis was conducted. Thirty-eight patients with AKI admitted to the intensive care medicine of the Third People's Hospital of Henan Province from January 2018 to May 2023 were enrolled...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38435634/gender-differences-in-the-incidence-of-nephropathy-and-changes-in-renal-function-in-patients-with-type-2-diabetes-mellitus-a-retrospective-cohort-study
#15
JOURNAL ARTICLE
Fan Zhang, Yan Han, Guojun Zheng, Wenjian Li
PURPOSE: This research aims to examine and scrutinize gender variations in the incidence of diabetic nephropathy (DN) and the trajectory of renal function in type 2 diabetes mellitus (T2DM) patients. PATIENTS AND METHODS: We conducted a retrospective cohort study that enrolled 1549 patients diagnosed with T2DM from May 2015 to July 2023. We separately compared the clinical characteristics of male and female participants with and without DN. We utilized the Kaplan-Meier method to examine the cumulative incidence of DN among T2DM patients of varying genders...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38434940/preliminary-study-of-the-role-of-nanobacteria-in-the-formation-of-renal-stones-in-experimental-rats-and-its-mechanism
#16
JOURNAL ARTICLE
Heng Yang, Xiaofeng Cheng, Yujun Chen, Zhenhao Zeng, Gongxian Wang
INTRODUCTION: The aim of the study was to study the role of nanobacteria in the formation of renal calculi and the underlying mechanism. MATERIAL AND METHODS: A total of 90 clean Wistar male rats were randomly divided into a negative control group, an experimental group, and an interference group. From the end of the first week of modelling, 10 consecutive times once a week, 3 rats in each group were randomly selected to measure the biochemical blood markers and urine metabolism...
2024: Archives of Medical Sciences. Atherosclerotic Diseases
https://read.qxmd.com/read/38431600/coenzyme-q10-supplementation-in-burn-patients-a-double-blind-placebo-controlled-randomized-clinical-trial
#17
JOURNAL ARTICLE
Zahra Kiani, Nadereh Khorsand, Fahimeh Beigi, Gholamreza Askari, Manoj Sharma, Mohammad Bagherniya
BACKGROUND: Burn injuries are important medical problems that, aside from skin damage, cause a systemic response including inflammation, oxidative stress, endocrine disorders, immune response, and hypermetabolic and catabolic responses which affect all the organs in the body. The aim of this study was to determine the effect of coenzyme Q10 (CoQ10) supplementation on inflammation, oxidative stress, and clinical outcomes in burn patients. METHODS: In a double-blind placebo-controlled randomized clinical trial, 60 burn patients were randomly assigned to receive 100 mg CoQ10 three times a day (total 300 mg/day) or a placebo for 10 days...
March 2, 2024: Trials
https://read.qxmd.com/read/38430141/differential-analysis-of-blood-routine-examination-parameters-in-patients-with-upper-gastrointestinal-bleeding-and-lower-gastrointestinal-bleeding
#18
JOURNAL ARTICLE
Jun Wang, Houwei Ren, Bin Gu, Yuezhan Zhang
BACKGROUND: This study addresses the critical need for differentiating between upper and lower gastrointestinal bleeding by focusing on blood routine parameters to enhance diagnostic precision. OBJECTIVE: This study aims to identify and compare specific blood routine parameters to determine their efficacy in distinguishing between upper and lower gastrointestinal bleeding for improved clinical decision-making. METHODS: This retrospective study analyzed 119 patients with gastrointestinal bleeding (GIB) admitted to our hospital between January 2017 and June 2020...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38404552/suppression-of-nlrp3-inflammasome-activation-by-astragaloside-iv-via-promotion-of-mitophagy-to-ameliorate-radiation-induced-renal-injury-in-mice
#19
JOURNAL ARTICLE
Yanping Ding, Shuning Liu, Mengqing Zhang, Meile Su, Baoping Shao
BACKGROUND: Irradiation (IR) promotes inflammation and apoptosis by inducing oxidative stress and/or mitochondrial dysfunction (MD). The kidneys are rich in mitochondria, and mitophagy maintains normal renal function by eliminating damaged mitochondria and minimizing oxidative stress. However, whether astragaloside IV (AS-IV) can play a protective role through the mitophagy pathway is not known. METHODS: We constructed a radiation injury model using hematoxylin and eosin (HE) staining, blood biochemical analysis, immunohistochemistry, TdT-mediated dUTP nick end labeling (TUNEL) staining, ultrastructural observation, and Western blot analysis to elucidate the AS-IV resistance mechanism for IR-induced renal injury...
January 31, 2024: Translational Andrology and Urology
https://read.qxmd.com/read/38395357/dexmedetomidine-and-acute-kidney-injury-after-non-cardiac-surgery-a-meta-analysis-with-trial-sequential-analysis
#20
REVIEW
Kai Zhuang, Hao-Tian Yang, Yu-Qin Long, Hong Liu, Fu-Hai Ji, Ke Peng
BACKGROUND: Acute kidney injury (AKI) is a common complication after surgery and is associated with detrimental outcomes. This systematic review and meta-analysis evaluated perioperative dexmedetomidine on AKI and renal function after non-cardiac surgery. METHODS: PubMed, Embase, and Cochrane Library databases were searched until August 2023 for randomised trials comparing dexmedetomidine with normal saline on AKI and renal function in adults undergoing non-cardiac surgery...
February 21, 2024: Anaesthesia, Critical Care & Pain Medicine
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