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https://www.readbyqxmd.com/read/29355720/zileuton-alleviates-acute-cisplatin-nephrotoxicity-inhibition-of-lipoxygenase-pathway-favorably-modulates-the-renal-oxidative-inflammatory-caspase-3-axis
#1
Mai M Helmy, Amel A Hashim, Samar M Mouneir
OBJECTIVE: The current study investigated for the first time the possible beneficial effect of zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal failure. METHODOLOGY: Male Sprague-Dawley rats (180-200 g) were administered cisplatin once (5 mg/kg, i.p.) alone or combined with oral zileuton (10 mg/kg, given twice; 1 hour before and 12 hours after cisplatin). RESULTS: Compared with control rats, acute cisplatin administration caused significant increases of BUN (33...
January 17, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29355652/liraglutide-ameliorates-early-renal-injury-by-the-activation-of-renal-foxo1-in-a-type-2-diabetic-kidney-disease-rat-model
#2
Pin Chen, Xiaozhi Shi, Xiangjin Xu, Yiyang Lin, Zhulin Shao, Rongdan Wu, Lihong Huang
AIMS: The aim of this study was to investigate the effects of liraglutide on renal injury and the renal expression of FoxO1 in type 2 diabetic rats. METHODS: Type 2 diabetic rats model was induced by a high-sugar and high-fat diet and intraperitoneal injection of low-dose Streptozotocin (STZ)(30 mg/kg). Five weeks after STZ injection, diabetic rats were randomly treated with or without subcutaneous injection of liraglutide (0.2 mg/kg/12 h) for eight weeks. Diabetes-related physical and biochemical indicators, renal histopathological and ultrastructural changes, the expression of renal transforming growth factor beta-1 (TGF-β1), fibronectin (FN), type IV collagen (Col IV), protein kinase B (Akt), forkhead box protein O1 (FoxO1) and manganese superoxide dismutase (MnSOD) were measured...
January 17, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29355283/reliability-and-validity-of-the-english-chinese-and-malay-language-versions-of-the-world-health-organization-quality-of-life-whoqol-bref-questionnaire-in-singapore
#3
Yin Bun Cheung, Khung Keong Yeo, Kok Joon Chong, Eric Yh Khoo, Hwee Lin Wee
INTRODUCTION: The World Health Organization Quality of Life (WHOQOL-BREF) questionnaire is a 26-item questionnaire that evaluates 4 domains of quality of life (QoL), namely Physical, Psychological, Social Relationships and Environment. This study aimed to evaluate the validity and reliability of the WHOQOL-BREF among Singapore residents aged 21 and above. MATERIALS AND METHODS: We recruited participants from the general population by using multistage cluster sampling and participants from 2 hospitals by using convenience sampling...
December 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29355065/effect-of-combination-of-vitamin-e-and-umbilical-cord-derived-mesenchymal-stem-cells-on-inflammation-in-mice-with-acute-kidney-injury
#4
Qiongqiong Guo, Junxia Wang
BACKGROUND: The objective of this study is to investigate the effect of combination of umbilical cord-derived mesenchymal stem cell (UC-MSC) and vitamin E (VitE) on inflammation in mice with acute kidney injury (AKI). METHODS: UC-MSCs were isolated from pregnant wistar mice and cultured. A total of 90 female wistar mice were randomly divided into control group, AKI group, AKI + VitE group, AKI + UC-MSC group, and AKI + VitE + UC-MSC group (18 mice in each group) which were given no treatment, normal saline, VitE, UC-MSC, and VitE + UC-MSC, respectively...
January 22, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29354930/-skin-needle-embedding-for-obese-impaired-glucose-tolerance
#5
Jinghua Liang, Zhendi Feng, Shengkui Feng, Shude Bao, Kejia Wang
OBJECTIVE: To explore the effect difference between the skin needle embedding therapy and western medication for obese impaired glucose tolerance (IGT). METHODS: A total of 300 cases of obese IGT were assigned into an embedding group and a western medication group by random number table, 150 cases in each one. Standardized diagnosis and treatment programs were applied to reduce blood pressure, lipid, weight, and exercise and scientific diet management were used...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29351251/compatibility-with-panax-notoginseng-and-rehmannia-glutinosa-alleviates-the-hepatotoxicity-and-nephrotoxicity-of-tripterygium-wilfordii-via-modulating-the-pharmacokinetics-of-triptolide
#6
Qichun Zhang, Yiqun Li, Mengzhu Liu, Jinao Duan, Xueping Zhou, Huaxu Zhu
Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on the autoimmune disorders and simultaneously ineluctable hepatotoxicity and nephrotoxicity. Combinational application of Panax notoginseng (PN) and Rehmannia glutinosa (RG) weakens the toxicity of TW according the clinical application of traditional Chinese medicine. This article was aimed at the mechanism of decreasing toxicity of TW by the combinational application of PN and RG. Biochemical and pathohistological analysis were utilized to assess the toxicity on liver and kidney in rats administrated with TW, TW-PN, TW-RG and TW-PN-RG for 3 and 7 days...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29350616/a-disassembly-driven-mechanism-explains-f-actin-mediated-chromosome-transport-in-starfish-oocytes
#7
Philippe Bun, Serge Dmitrieff, Julio M Belmonte, François J Nédélec, Péter Lénárt
While contraction of sarcomeric actomyosin assemblies is well understood, this is not the case for disordered networks of actin filaments (F-actin) driving diverse essential processes in animal cells. For example, at the onset of meiosis in starfish oocytes a contractile F-actin network forms in the nuclear region transporting embedded chromosomes to the assembling microtubule spindle. Here, we addressed the mechanism driving contraction of this 3D disordered F-actin network by comparing quantitative observations to computational models...
January 19, 2018: ELife
https://www.readbyqxmd.com/read/29349452/barriometry-an-enhanced-database-of-accurate-barrier-heights-for-gas-phase-reactions
#8
Bun Chan, John M Simmie
The kinetics of many reactions are critically dependent upon the barrier heights for which accurate determination can be difficult. From the perspective of attaining such quantities using computational quantum chemistry, it is important to appropriately validate routine and efficient methodologies such as density functional theory (DFT) procedures. In the present study, we embark on the journey of establishing diverse databases using a consistent high-level quantum chemistry procedure, against which new and existing methodologies can be assessed...
January 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29345438/evaluation-of-hepatic-glycogen-content-some-haematological-and-biochemical-parameters-of-alloxan-induced-diabetic-rats-treated-with-combinations-of-glibenclamide-and-g-latifolium-extract
#9
Patrick E Aba
Background Diabetes is associated with both biochemical and haematological complications. Combination therapy has been advocated to mitigate some of these complications. Aim This study was designed to investigate the effects of glibenclamide and Gongronema latifolium (GL) on hepatic glycogen content and haemato-biochemical parameters. Methods Thirty male Wistar rats were assigned into five groups of six rats each. Groups 2-5 rats received intraperitoneally, 160 mg/kg of alloxan monohydrate while group 1 rats served as normal control...
May 4, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29344650/adrenomedullin-serves-a-role-in-the-humoral-pathway-of-delayed-remote-ischemic-preconditioning-via-a-hypoxia-inducible-factor-1%C3%AE-associated-mechanism
#10
Wenpei Dong, Ping Yu, Tielong Zhang, Chenzhuang Zhu, Jun Qi, Junhao Liang
Remote ischemic preconditioning (RIPC) is a minimally invasive method that provides protection by reducing injury to the heart, kidneys, brain and other tissues or organs. RIPC may improve the outcome in patients undergoing surgery. Although the role of RIPC has been studied, the results remain controversial. It is difficult to confirm whether RIPC has a kidney protective effect and the understanding of the preconditioning signal pathway involved remains unclear. In the present study, the effect of RIPC in urology was evaluated...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344027/plasma-volume-and-renal-function-predict-six-month-survival-after-hospitalization-for-acute-decompensated-heart-failure
#11
Kenneth C Bilchick, Nathaniel Chishinga, Alex M Parker, David X Zhuo, Mitchell H Rosner, LaVone A Smith, Hunter Mwansa, Jacob N Blackwell, Peter A McCullough, Sula Mazimba
Background: Plasma volume (PV) is contracted in stable patients with heart failure (HF) due to decongestion strategies. On the other hand, increased PV can adversely affect the trajectory of HF. We therefore examined the effects of increased percentage change in PV (%ΔPV), blood urea nitrogen (BUN), and %ΔPV stratified by BUN and glomerular filtration rate (GFR) on survival after discharge in patients hospitalized for acute decompensated HF (ADHF). Methods: We used the Strauss-Davis-Rosenbaum formula to calculate the %ΔPV between baseline and hospital discharge in a cohort from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness trial (ESCAPE)...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29343032/-incidence-and-short-term-outcomes-of-acute-kidney-injury-in-very-elderly-patients
#12
Q L Li, K Li, X D Wang, M Zhao
Objectives: To study the incidence, clinical characteristics, and prognostic impact of acute kidney injury (AKI) in very elderly patients. Methods: The very elderly patients (≥75 years) from the Geriatric Department of the Chinese PLA General Hospital between January 2007 and December 2015 were retrospectively enrolled. AKI was defined according to the 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. AKI patients were divided into survivor group and non-survivor group by their outcomes within 90 days after AKI...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29342468/the-role-of-history-of-gastro-duodenal-ulcer-in-patients-with-upper-gastrointestinal-bleeding
#13
Yusaku Takatori, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keichiro Abe, Yoshiaki Takada, Tetsu Hirata, Shigeo Banno, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Miho Kikuchi, Masahiro Kikuchi, Masayuki Suzuki, Toshio Uraoka
BACKGROUND: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. AIM: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. METHODS: This is a retrospective cross-sectional study...
January 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29341261/consensus-statements-on-the-clinical-understanding-and-use-of-milnacipran-in-hong-kong
#14
REVIEW
Wing King Lee, Kwok Leung Au Yeung, Ho Bun Lam, Chi Keung Wong, Ming Kai Au, Hoi Yee Karina Chan, Yat Wo Eric Cheung, Wing Ho Chui, Ting Chi Vanessa Wong, Chi Kin Fu, Shiu Kow Sham, Ki Yan Mak
OBJECTIVE: Our aim is to develop a local consensus to guide medical practitioners and psychiatrists on the use of milnacipran in different psychiatric conditions. METHODS: By utilizing the modified Delphi technique, 12 statements were electronically voted on anonymously for their practicability of recommendation. RESULTS: There was a very high degree of agreement among the consensus group on 10 finalized consensus statements, but 2 statements were voted down due to a poor degree of agreement...
January 17, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29341028/ameliorative-effects-of-zataria-multiflora-hydro-alcoholic-extract-on-gentamicin-induced-nephrotoxicity-in-rats
#15
Saeed Hajihashemi, Tahereh Jafarian, Mahboubeh Ahmadi, Ali Rahbari, Fatemeh Ghanbari
BACKGROUND: Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim of this study was to investigate the therapeutic effects of Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity. METHODS: Twenty-eight male Wistar rats categorized into four groups: 1) the control group without injection, 2) the gentamicin treated group (100 mg/kg, i.p) 3) the gentamicin and Z. Multiflora treated group; Z. Multiflora extract(0...
January 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29340105/long-term-effects-of-sitagliptin-in-patients-with-type-2-diabetes-mellitus-and-hypertension-results-from-the-prologue-study
#16
Ziliang Ye, Hui Li, Haili Lu, Qiang Su, Lang Li
Background: The effects of sitagliptin in patients with type 2 diabetes mellitus and hypertension are unclear. Therefore, we evaluated the long-term effects of sitagliptin in those patients. Methods: In the PROLOGUE study, 365 patients were diagnosed as type 2 diabetes mellitus and hypertension, and 189 patients in the sitagliptin group, 176 patients in the conventional group. Fasting blood glucose (FBG), HbA1c, systolic pressure (SP), diastolic pressure (DP), serum urea nitrogen (BUN) and serum creatinine (SCR) were measured at the beginning of the study and after 12 and 24 months of treatment...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29333040/pharmacological-screening-of-trachyspermum-ammi-for-antihyperlipidemic-activity-in-triton-x-100-induced-hyperlipidemia-rat-model
#17
Uzma Saleem, Saba Riaz, Bashir Ahmad, Mohammad Saleem
Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332864/associations-of-periparturient-plasma-biochemical-parameters-endometrial-leukocyte-esterase-and-myeloperoxidase-and-bacterial-detection-with-clinical-and-subclinical-endometritis-in-postpartum-dairy-cows
#18
Sayed Ahmad Nazhat, Go Kitahara, Nobutoshi Kozuka, Shogo Mido, Mohammed Sadawy, Hossam El-Sheikh Ali, Takeshi Osawa
This study was aimed at demonstrating associations between peripheral biochemical parameters, endometrial leukocyte esterase (LE) and myeloperoxidase (MPO), and bacterial detection with the degree of endometrial inflammation, and determining the best time postpartum for diagnosing endometritis to predict subsequent fertility in dairy cows. Plasma albumin, blood urea nitrogen (BUN), total cholesterol (T-cho), NEFA, and BHBA concentrations were analyzed in 43 Holstein cows at 3, 5 and 7 weeks postpartum (W3, W5 and W7)...
January 12, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29329595/human-umbilical-cord-mesenchymal-stem-cell-conditioned-medium-attenuates-renal-fibrosis-by-reducing-inflammation-and-epithelial-to-mesenchymal-transition-via-the-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway-in-vivo-and-in-vitro
#19
Bo Liu, Fengxia Ding, Dong Hu, Yu Zhou, Chunlan Long, Lianju Shen, Yuanyuan Zhang, Deying Zhang, Guanghui Wei
BACKGROUND: Renal fibrosis is characterized by infiltration of interstitial inflammatory cells and release of inflammatory mediators, activation and proliferation of fibroblasts, and deposition of excessive extracellular matrix (ECM). The aim of this study was to evaluate the effect of human umbilical cord-derived mesenchymal stem cell (hucMSC) conditioned medium (CM) on renal tubulointerstitial inflammation and fibrosis. METHODS: Renal interstitial fibrosis was prepared in vivo using the unilateral ureteral obstruction (UUO)...
January 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29314458/quality-of-omeprazole-purchased-via-the-internet-and-personally-imported-into-japan-comparison-with-products-sampled-in-other-asian-countries
#20
Mohammad Sofiqur Rahman, Naoko Yoshida, Sakura Sugiura, Hirohito Tsuboi, Tep Keila, Heng Bun Kiet, Theingi Zin, Tsuyoshi Tanimoto, Kazuko Kimura
OBJECTIVE: To evaluate the quality of omeprazole personally imported into Japan via the internet and to compare the quality of these samples with previously collected samples from two other Asian countries. METHODS: The samples were evaluated by observation, authenticity investigation, and pharmacopoeial quality analysis. Quality comparison of some selected samples was carried out by dissolution profiling, Raman spectroscopy, and principle component analysis (PCA)...
January 5, 2018: Tropical Medicine & International Health: TM & IH
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