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https://www.readbyqxmd.com/read/28815220/severity-and-outcomes-of-acute-alcoholic-pancreatitis-in-cannabis-users
#1
Hemant Goyal, Kelsey Guerreso, Betsy Smith, Kaitlin Harper, Sheetal Patel, Akash Patel, Puja Parikh
BACKGROUND: Cannabis is the most commonly and widely used illicit drug in the world and is also the most commonly used drug of abuse in alcohol drinkers. Experimental studies have shown conflicting results of the effects of cannabis on the severity of acute pancreatitis (AP). The purpose of this study is to ascertain the clinical effects of simultaneous alcohol and cannabis use on severity at presentation and outcomes of acute alcoholic pancreatitis (AAP). METHODS: A retrospective review was conducted on the patients discharged with principle or secondary diagnosis of AP using ICD-9 & ICD-10 codes during the time period from January 2006 to December 2015 at a large community-based hospital in Central Georgia...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28810635/curcumin-protects-against-acute-renal-injury-by-suppressing-jak2-stat3-pathway-in-severe-acute-pancreatitis-in-rats
#2
Shuaijun Zhu, Chi Zhang, Qinyong Weng, Bing Ye
The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured. Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured using ELISA kits...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808840/comparison-of-health-state-values-derived-from-patients-and-individuals-from-the-general-population
#3
Mihir Gandhi, Ru San Tan, Raymond Ng, Su Pin Choo, Whay Kuang Chia, Chee Keong Toh, Carolyn Lam, Phong Teck Lee, Nang Khaing Zar Latt, Kim Rand-Hendriksen, Yin Bun Cheung, Nan Luo
PURPOSE: Utility values are critical for cost-utility analyses that guide healthcare decisions. We aimed to compare the utility values of the 5-level EuroQoL-5Dimension (EQ-5D-5L) health states elicited from members of the general public and patients with heart disease or cancer. METHODS: In face-to-face interviews with 157 heart disease patients, 169 cancer patients, and 169 members from the general population, participants valued 10 EQ-5D-5L health states using a composite Time Trade-Off method...
August 14, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28805489/atorvastatin-attenuates-experimental-contrast-induced-acute-kidney-injury-a-role-for-tlr4-myd88-signaling-pathway
#4
Rongzheng Yue, Chuan Zuo, Jing Zeng, Baihai Su, Ye Tao, Songmin Huang, Rui Zeng
OBJECTIVES: To investigate the protective effect of different atorvastatin doses on contrast-induced acute kidney injury and the related mechanism. METHODS: Healthy male Sprague-Dawley (SD) rats were randomly divided into the blank control group, experimental control group and different-dose atorvastatin groups. A rat model of contrast-induced acute kidney injury was established. We detected changes in serum creatinine (Scr) and blood urea nitrogen (BUN) before and after model establishment, observed and scored renal tubular injury, analyzed rat renal cell apoptosis, and measure the expression of signal pathway proteins and downstream inflammatory factors...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28804538/exendin-4-assisted-adipose-derived-mesenchymal-stem-cell-therapy-protects-renal-function-against-co-existing-acute-kidney-ischemia-reperfusion-injury-and-severe-sepsis-syndrome-in-rat
#5
Pei-Hsun Sung, Hsin-Ju Chiang, Christopher Glenn Wallace, Chih-Chao Yang, Yen-Ta Chen, Kuan-Hung Chen, Chih-Hung Chen, Pei-Lin Shao, Yung-Lung Chen, Sarah Chua, Han-Tan Chai, Yi-Ling Chen, Tien-Hung Huang, Hon-Kan Yip, Mel S Lee
This study tested the hypothesis that combined therapy with exendin-4 (Ex4) and autologous adipose-derived mesenchymal stem cells (ADMSCs) was superior to either alone for protecting renal function against acute kidney ischemia-reperfusion (IR; 40-min ischemia/27-h reperfusion) injury when complicated by sepsis syndrome (SS; by cecal-ligation-puncture). Adult-male Sprague-Dawley rats (n=40) were equally divided into group 1 (sham-control), group 2 (IR-SS), group 3 (IR-SS + Ex4, 10 μg/kg subcutaneously 30 min after reperfusion and daily for 3 days), group 4 [IR-SS + ADMSC (1...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28801710/randomized-controlled-trial-of-endowrist-enabled-robotic-versus-human-laparoendoscopic-single-site-access-surgery-less-in-the-porcine-model
#6
Anthony Yuen Bun Teoh, Shannon Melissa Chan, Hon Chi Yip, Vivien Wai Yin Wong, Philip Wai Yan Chiu, Enders Kwok Wai Ng
INTRODUCTION: A robotic laparoendoscopic single-site access surgery (R-LESS) platform that incorporates the EndoWrist function of robotic instruments may provide better triangulation and retraction during LESS. The aim of the study is to assess if R-LESS is feasible with standard robotic instruments via a single incision and whether the approach could reduce the difficulty of the procedure and confer additional benefits over conventional LESS. METHODS: This was a prospective randomized controlled study investigating the workload performance, efficacy, and risks of performing R-LESS when compared with human LESS (H-LESS) in a survival porcine model for cholecystectomy and gastrojejunostomy...
August 11, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28799261/serum-osmolarity-in-male-patients-with-bipolar-disorder-manic-episode
#7
Tevfik Kalelioglu, Nesrin Karamustafalioglu, Abdullah Genc, Murat Kocabiyik
Imbalance of water and electrolyte homeostasis has been suggested to be associated with the acute episodes of bipolar disorder. In this study we aimed to investigate, for the first time, the serum osmolarity in bipolar disorder manic episode. A total of 68 bipolar inpatients in manic episode and 60 age-gender matched healthy controls were included in the study. Serum osmolarity was calculated from Sodium (Na(+) ), glucose and blood urea nitrogen (BUN) according to formula of (2 × Na(+) ) + (BUN/2.8) + (Glucose/18)...
August 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28794893/effect-of-dietary-sugar-beet-pulp-supplementation-on-growth-performance-nutrient-digestibility-fecal-microflora-blood-profiles-and-diarrhea-incidence-in-weaning-pigs
#8
C L Yan, H S Kim, J S Hong, J H Lee, Y G Han, Y H Jin, S W Son, S H Ha, Y Y Kim
BACKGROUND: In 2006, the European Union (EU) has decided to forbid use of antibiotics as growth promoters. Although many researches had been conducted about fiber source as alternatives of antibiotics, there are still lack of reports in the literature about the optimum level of sugar beet pulp supplementation, affecting growth performance and nutrient digestibility in weaning pigs. Therefore, different level of sugar beet pulp was added to diets to determine the effects of sugar beet pulp supplementation on growth performance, nutrient digestibility, fecal microflora, blood profile and incidence of diarrhea in weaning pigs...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28794206/lipid-based-nutrient-supplements-during-pregnancy-and-lactation-did-not-affect-human-milk-oligosaccharides-and-bioactive-proteins-in-a-randomized-trial
#9
Josh M Jorgensen, Charles Arnold, Per Ashorn, Ulla Ashorn, David Chaima, Yin Bun Cheung, Jasmine Cc Davis, Yue-Mei Fan, Elisha Goonatilleke, Emma Kortekangas, Chiza Kumwenda, Carlito B Lebrilla, Kenneth Maleta, Sarah M Totten, Lauren D Wu, Kathryn G Dewey
Background: Human milk oligosaccharides (HMOs) and bioactive proteins are beneficial to infant health. Recent evidence suggests that maternal nutrition may affect the amount of HMOs and proteins in breast milk; however, the effect of nutrient supplementation on HMOs and bioactive proteins has not yet been well studied.Objective: We aimed to determine whether lipid-based nutrient supplements (LNSs) affect milk bioactive protein and HMO concentrations at 6 mo postpartum in women in rural Malawi. These are secondary outcomes of a previously published randomized controlled trial...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28793319/community-burden-and-prognostic-impact-of-reduced-kidney-function-among-patients-hospitalized-with-acute-decompensated-heart-failure-the-atherosclerosis-risk-in-communities-aric-study-community-surveillance
#10
Kunihiro Matsushita, Lucia Kwak, Noorie Hyun, Marina Bessel, Sunil K Agarwal, Laura R Loehr, Hanyu Ni, Patricia P Chang, Josef Coresh, Lisa M Wruck, Wayne Rosamond
BACKGROUND: Kidney dysfunction is prevalent and impacts prognosis in patients with acute decompensated heart failure (ADHF). However, most previous reports were from a single hospital, limiting their generalizability. Also, contemporary data using new equation for estimated glomerular filtration rate (eGFR) are needed. METHODS AND RESULTS: We analyzed data from the ARIC Community Surveillance for ADHF conducted for residents aged ≥55 years in four US communities between 2005-2011...
2017: PloS One
https://www.readbyqxmd.com/read/28793292/huangqi-decoction-ameliorates-streptozotocin-induced-rat-diabetic-nephropathy-through-antioxidant-and-regulation-of-the-tgf-%C3%AE-mapk-ppar-%C3%AE-signaling
#11
Haiyan Han, Aili Cao, Li Wang, Hengjiang Guo, Yingjun Zang, Zezheng Li, Xuemei Zhang, Wen Peng
BACKGROUND/AIMS: Huangqi Decoction (HQD) has been traditionally used to treat diabetes mellitus in China. The present study was carried out to assess the protective effect of HQD on diabetic nephropathy (DN) using the streptozotocin-induced (STZ) diabetic rats. METHODS: Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg) in male Wistar rats. 40 diabetic rats were divided into 5 groups: vehicle-treated (DN group), 0.45, 0.15, 0.05 g/kg HQD-treated diabetic group (HQD group) and 1 mg/kg rosiglitazone-treated diabetic group (RGZ group)...
August 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28793037/impact-of-propofol-on-renal-ischemia-reperfusion-endoplasmic-reticulum-stress
#12
Mengqin Su, Sueng Ren, Wei Zhong, Xueping Han
Purpose: To investigate the protective mechanisms of propofol (Pro) on renal ischemia/reperfusion (I/R) injury by studying its impact on renal I/R endoplasmic reticulum stress. Methods: Eighteen male Sprague-Dawley rats (SD rats) were randomly divided into three groups: the I/R group, the Pro pretreatment group, and the control group, and corresponding treatments were performed. The levels of serum creatinine (Cr) and blood urea nitrogen (BUN) of each group were detected...
July 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28791440/therapeutic-potentials-of-short-interfering-rnas
#13
REVIEW
Chit Tam, Jack Ho Wong, Randy Chi Fai Cheung, Tao Zuo, Tzi Bun Ng
Short interfering RNA (siRNA) is one of the members of the family of RNA interference (RNAi). Coupled with the RNA-induced silencing complex (RISC), siRNA is able to trigger the cleavage of target RNAs which serve as a defensive system against pathogens. Meanwhile, siRNA in gene silencing opens a new avenue for the treatment of various diseases. SiRNA can effectively inhibit viral infection and replication and suppress tumorigenesis and various inflammation-associated diseases and cardiovascular diseases by inactivation of viral genes and downregulation of oncogene expression...
August 8, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28790043/associations-between-hyponatraemia-volume-depletion-and-the-risk-of-falls-in-us-hospitalised-patients-a-case-control-study
#14
Elizabeth A Fehlberg, Robert J Lucero, Michael T Weaver, Anna M McDaniel, A Michelle Chandler, Phyllis A Richey, Lorraine C Mion, Ronald I Shorr
OBJECTIVE: We aimed to determine if abnormal laboratory values which may indicate volume depletion are associated with increased odds of experiencing a hospital-acquired fall. DESIGN: Matched case-control study. SETTING: Four hospitals located in the Southeast USA. PARTICIPANTS: Data from 699 adult fallers and 1189 matched controls (non-fallers) were collected via chart review from 2005 to 2010. Controls were matched to cases by nursing unit, time of fall and length of stay...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28789728/circadian-feeding-patterns-of-12-month-old-infants
#15
Poh Hui Wee, See Ling Loy, Jia Ying Toh, Elaine Kwang Hsia Tham, Yin Bun Cheung, Keith M Godfrey, Peter D Gluckman, Seang Mei Saw, Yap-Seng Chong, Ngee Lek, Jerry Kok Yen Chan, Daniel Yam Thiam Goh, Mary Foong-Fong Chong, Fabian Yap
Early life nutrition and feeding practices are important modifiable determinants of subsequent obesity, yet little is known about the circadian feeding pattern of 12-month-old infants. We aimed to describe the 24-h feeding patterns of 12-month-old infants and examine their associations with maternal and infant characteristics. Mothers from a prospective birth cohort study (n 431) reported dietary intakes of their 12-month-old infants and respective feeding times using 24-h dietary recall. Based on their feeding times, infants were classified into post-midnight (00...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28780798/-effect-of-liangge-powder-on-expression-of-inflammatory-mediators-and-hepatic-and-renal-function-in-rats-with-sepsis
#16
P P Zhang, Z J Li, D Q Wang
Objective: To investigate the effect of Liangge powder on the expression of inflammatory mediators and hepatic and renal function in rats with sepsis via a preliminary analysis. Methods: A total of 195 Wistar rats were randomly divided into sham-operation group (15 rats) , model group (90 rats) , and treatment group (90 rats) using a random number table, and according to the time point after modeling, the model group and the treatment group were further divided into 24, 48, and 72 hour subgroups, with 30 rats in each subgroup...
May 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28780414/chitosan-coated-pluronicf127-micelles-for-effective-delivery-of-amphotericin-b-in-experimental-visceral-leishmaniasis
#17
Pankaj K Singh, Vivek K Pawar, Anil K Jaiswal, Yuvraj Singh, Cheruvu Hanumanth Srikanth, Mohini Chaurasia, Himangsu K Bora, Kavit Raval, Jaya Gopal Meher, Jiaur R Gayen, Anuradha Dube, Manish K Chourasia
The goal of study was to develop micellar formulation of Amphotericin B (AmB) to improve its antileishmanial efficacy. AmB loaded pluronic F127 (PF 127) micelles were developed and coated with chitosan (Cs-PF-AmB-M) to accord immunoadjuvant and macrophage targeting properties. Hemolysis and cytotoxicity studies demonstrated that Cs-PF-AmB-M was 7.93 fold (at 20μg/ml AmB concentration) and 9.35 fold less hemolytic and cytotoxic, respectively in comparison to AmB suspension. Flow cytometry studies indicated that Cs-PF-FITC-M was 21...
August 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28777392/long-term-follow-up-of-continuous-flow-left-ventricular-assist-devices-complications-and-predisposing-risk-factors
#18
Tolulope A Adesiyun, Rhondalyn C McLean, Ryan J Tedford, Glenn J R Whitman, Chris M Sciortino, John V Conte, Ashish S Shah, Stuart D Russell
PURPOSE: To assess LVAD complications and their overall effect on mortality and determine factors associated with development of early and long-term complications. METHODS: A retrospective cohort study of patients who underwent continuous flow LVAD placement between January 1, 2000 and November 30, 2013 was performed. The incidence of complications (sepsis or bacteremia, driveline infections, gastrointestinal bleeding, pump thrombosis, cerebrovascular accidents and anemia requiring transfusion) was collected and logistic regression and Cox proportional hazards analyses were performed...
August 2, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28776730/effect-of-feed-deprivation-on-selected-parameters-of-lipid-mobilisation-and-hepatic-function-in-healthy-akhal-teke-horses
#19
B Tóth, A Auth, L Rompos, Z Bakos
BACKGROUND: Gastrointestinal and other systemic diseases of Equidae are often characterised by partial or complete inappetence. The catabolic processes may lead to lipid mobilisation and other metabolic disturbances. Evidence from earlier studies has revealed that during feed deprivation/inappetence, the conjugation of bilirubin is reduced causing a substantial rise of the total bilirubin and its unconjugated fraction. OBJECTIVES: We hypothesised that during feed deprivation, the serum concentration of free fatty acids (FFA), triglycerides (TG), blood urea nitrogen (BUN), total bilirubin (tBIL) total bile acids (tBA) and activity of GGT and GLDH increase, while the concentration of insulin and direct bilirubin (dBIL) decrease...
August 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28774335/a-comparative-study-on-the-efficacy-of-a-retrograde-perfusion-technique-and-an-antegrade-perfusion-technique-for-donor-kidney-recovery-in-transplantation-in-pigs
#20
Xiuwu Han, Xuhui Zhu, Tao Li, Yansheng Li, Hui Shan, Peng Zhang, Bulang He
BACKGROUND: Donor organ shortage is a significant problem in kidney transplantation. Improvement of perfusion techniques can increase the number of available organs. The aim of this study is to investigate the efficiency and safety of retrograde perfusion (RP) of kidney grafts during organ recovery after transplantation in pigs. METHODS: Ten pigs were divided into two groups, six in the study group for the RP technique and four in the control group for standard antegrade perfusion (AP)...
August 3, 2017: BMC Surgery
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