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https://www.readbyqxmd.com/read/28938514/-2-4-fluorobenzamido-4-methylthiazole-5-carboxylic-acid-a-novel-thiazole-compound-ameliorates-insulin-sensitivity-and-hyperlipidaemia-in-streptozotocin-induced-diabetic-rats-plausible-role-of-inflammatory-and-oxidative-stress-markers
#1
Yam Nath Paudel, Md Rahmat Ali, Mohammad Adil, Sandhya Bawa, Manju Sharma
Emerging evidence suggests that thiazole compounds are of great interest due to their protective effect against DM. Protective effects of thiazole derivatives against hyperglycemia have been demonstrated in earlier in vitro and in vivo studies. Previously, anti-oxidant and free radical scavenging activities of 2-(4-Fluorobenzamido)-4-methylthiazole-5-carboxylicacid, a newly developed thiazole derivative (NDTD), have been well-documented. Current study investigated the pharmacological effect of NDTD on hyperglycaemia, insulin sensitivity, lipid profile, anti-inflammatory and oxidative stress markers in an animal model...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28937169/asymmetrically-substituted-triazenes-as-poor-electron-donor-ligands-in-the-precursor-chemistry-of-iron-ii-for-iron-based-metallic-and-intermetallic-nanocrystals
#2
Khaled Soussi, Shashank Mishra, Erwann Jeanneau, Jean-Marc M Millet, Stéphane Daniele
Triazene ligands are introduced, for the first time, in the precursor chemistry for their ability to afford oxygen-free molecular precursors of Fe(0) nanoparticles. For this purpose, we synthesized new asymmetric triazene ligands t-BuN[double bond, length as m-dash]N-NHR (R = Et, i-Pr, n-Bu) featuring different alkyl substituents at 1,3-N centers, as well as a symmetric ligand t-BuN[double bond, length as m-dash]N-NHt-Bu and used them to develop novel heteroleptic monomeric Fe(II) triazenide derivatives [Fe(t-BuN3R)2(TMEDA)] (where TMEDA = tetramethylethylenediamine)...
September 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28932489/the-impact-of-cardiac-resynchronization-therapy-on-routine-laboratory-parameters
#3
András Mihály Boros, Péter Perge, Klaudia Vivien Nagy, Astrid Apor, Zsolt Bagyura, Endre Zima, Levente Molnár, Tamás Tahin, Dávid Becker, László Gellér, Béla Merkely, Gábor Széplaki
BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes. METHODS: A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28929659/-effects-and-mechanisms-of-shenkang-injection-promoting-extracellular-matrix-degradation-via-regulating-erk1-2-mmps-signaling-pathway-in-renal-failure-rats
#4
Jing-Jing Yang, Zhi-Min Mao, Yi-Gang Wan, Wei Wu, Yan-Ru Huang, Ge Shi, Wen-Bei Han, Jian Yao
This study aimed to clarify preliminarily the effects and mechanisms of Shenkang injection (SKI) promoting extracellular matrix(ECM)degradation via regulating extracellular-signal regulated protein kinase(ERK)1/2/matrix metalloproteinases(MMPs)signaling pathway in renal failure rats. Twenty rats were randomly divided into 4 groups:the Sham group,the Model group,the SKI group and the Enalapril maleate(EM)group. The model rats with renal failure were induced by intragastric administration of adenine and unilateral ureteral obstruction(UUO)...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928518/therapeutic-evaluation-of-grain-based-functional-food-formulation-in-a-geriatric-animal-model
#5
Deepa Teradal, Neena Joshi, Ravindranath H Aladakatti
This study investigates the effect of wholesome grain based functional food formulation, on clinical and biochemical parameters in 24-30 months old Wistar albino geriatric rats, corresponding to human age 60-75 years. Animals were randomly divided into five, groups. Experimental diets were compared to the basal rat diet (Group I). Four food, formulation were-wheat based (Group II), finger millet based (Group III), wheat based, diet + fenugreek seed powder (Group IV), finger millet based diet + fenugreek powder, (Group V)...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28927960/a-comparison-between-multipolar-mapping-and-conventional-mapping-of-atrial-tachycardias-in-the-context-of-atrial-fibrillation-ablation
#6
Sok-Sithikun Bun, Tahar Delassi, Decebal Gabriel Latcu, Mohammed El Jamili, Anis Ayari, Abdelkarim Errahmouni, Benjamin Berte, Nadir Saoudi
BACKGROUND: Activation mapping can be challenging and time-consuming in patients with multiple atrial tachycardias (ATs). AIMS: To compare multielectrode mapping using a dedicated mapping catheter - PentaRay (Biosense Webster Inc.) - and the conventional technique for mapping ATs in the context of atrial fibrillation (AF) ablation. METHODS: All procedures where PentaRay mapping of AT were used - after or during persistent AF ablation - were analysed...
September 15, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28927488/investigation-of-the-antifatigue-effects-of-korean-ginseng-on-professional-athletes-by-gas-chromatography-time-of-flight-mass-spectrometry-based-metabolomics
#7
Bei Yan, Yao Liu, Aixin Shi, Zhihong Wang, Jiye Aa, Xiaoping Huang, Yi Liu
Ginseng is usually used for alleviating fatigue. The purpose of this paper was to evaluate the regulatory effect of Korean ginseng on the metabolic pattern in professional athletes, and, further, to explore the underlying mechanism of the antifatigue effect of Korean ginseng. GC-time-of-flight-MS was used to profile serum samples from professional athletes before training and after 15 and 30 day training, and professional athletes administered with Korean ginseng in the meanwhile. Biochemical parameters of all athletes were also analyzed...
September 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28926934/the-beneficial-effects-of-allicin-in-chronic-kidney-disease-are-comparable-to-losartan
#8
Ehécatl Miguel Ángel García Trejo, Abraham Said Arellano Buendía, Omegar Sánchez Reyes, Fernando Enrique García Arroyo, Raúl Arguello García, María Lilia Loredo Mendoza, Edilia Tapia, Laura Gabriela Sánchez Lozada, Horacio Osorio Alonso
Recent studies suggest that allicin may play a role in chronic kidney disease (CKD), reducing hypertension and oxidative stress and improving renal dysfunction. In the present study, CKD was induced by 5/6 nephrectomy and the animals were divided into four treatment groups as follows: control (C), CKD, CKD+allicin (40 mg/kg pathway oral) (CKDA), and CKD+Losartan (20 mg/kg) (CKDL). After CKD induction, the rats developed hypertension from week 3 to the end of the study. This was associated with increased creatinine and blood urea nitrogen (BUN) levels in serum, increased albuminuria, increased urinary excretion of N-acetyl-β-d-glucosaminidase (NAG), increased nephrin expression, and incrased histological alterations in the cortex...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28923649/hypothermic-machine-perfusion-s-protection-on-porcine-kidney-graft-uncovers-greater-akt-erk-phosphorylation
#9
N He, J-H Li, J-J Jia, K-D Xu, Y-F Zhou, L Jiang, H-H Lu, S-Y Yin, H-Y Xie, L Zhou, S-S Zheng
BACKGROUND: To investigate the potential mechanisms of hypothermic machine perfusion (HMP)'s beneficial effects on kidney graft over static cold storage (SCS) in vitro. METHODS: Ten kidneys of 5 Bama miniature male pigs were paired into 2 groups: SCS group and HMP group. Preservation solutions were taken at 0, 1, 3, and 6 hours for the measurement of K(+), Na(+), Cl(-), blood urea nitrogen (BUN), creatinine (Cr), and lactate dehydrogenase (LDH) using the standard laboratory methods...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28919104/elevated-urinary-monocyte-chemoattractant-protein-1-levels-in-children-with-henoch-schonlein-purpura-nephritis
#10
Jiapei Wang, Qianqian Ying, Shiling Zhong, Yuanling Chen, Yazhen Di, Xiahua Dai, Jika Zheng, Mengjiao Shen
BACKGROUND: Chemokine monocyte chemoattractant protein-1 (MCP-1) has been proved as a potential urinary biomarker in nephropathies. The aim of this study was to investigate the urinary monocyte chemoattractant protein-1 (MCP-1) levels and clinical significance in Henoch-Schonlein purpura (HSP) children with and without nephritis and determine the association of MCP-1 with proteinuria. METHODS: A total of 261 HSP children-with or without nephritis-and 84 healthy control children were enrolled in this study...
August 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28918967/accuracy-of-bedside-point-of-care-testing-in-critical-emergency-department-patients
#11
Braden W McIntosh, Jerina Vasek, Maria Taylor, Deborah Le Blanc, Henry C Thode, Adam J Singer
BACKGROUND: Point-of-care (POC) testing reduces laboratory turn-around having the potential to improve timely diagnosis and management. We compared the accuracy of nurse performed POC and core laboratory testing and determined whether deviations between the two were clinically meaningful. METHODS: We performed a prospective, observational study on a convenience sample of 50 critical care ED patients in whom a POC chemistry and hematocrit was ordered. Blood samples were divided into 2 aliquots; one sample was tested by the treating nurse using a handheld POC device and the other sample was tested in the core laboratory...
September 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28917232/compressed-food-with-added-functional-oligopeptides-improves-performance-during-military-endurance-training
#12
Zhi-Qiang Zheng, Zhan-Hui Geng, Jia-Xi Liu, Shun-Tang Guo
BACKGROUND AND OBJECTIVES: Oligosaccharide or oligopeptide supplementation may have a significant impact on endurance performance. This study evaluated the effects of adding maltooligosaccharides (MO) or soy oligopeptides (SO) to compressed food (CF) on the physical response of soldiers to daily military training. METHODS AND STUDY DESIGN: Twelve soldiers were randomized to four diet groups: regular meals, CF, CFMO, and CFSO (crossover design). They participated in exercise tests including 90 minutes running at 55-65% VO2max and exhaustive running...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28916390/il-33-receptor-st2-deficiency-attenuates-renal-ischaemia-reperfusion-injury-in-euglycaemic-but-not-streptozotocin-induced-hyperglycaemic-mice
#13
M Sehnine, M Ferhat, S Sena, J M Gombert, J M Goujon, A Thierry, G Touchard, T Hauet, A Herbelin, S Hadjadj
AIM: Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS: Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice...
September 12, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28911689/effect-of-oleuropein-against-chemotherapy-drug-induced-histological-changes-oxidative-stress-and-dna-damages-in-rat-kidney-injury
#14
Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek
Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of pharmacological beneficial properties. In this study we investigated whether OLE could provide sufficient protection against cisplatin-induced nephrotoxicity. With this aim, Sprague-Dawley rats were divided into eight groups: control; 7 mg/kg/d cisplatin, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE; and treatment with OLE for 3 days starting at 24 hours following cisplatin injection...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904946/high-density-lipoprotein-cholesterol-blood-urea-nitrogen-and-serum-creatinine-can-predict-severe-acute-pancreatitis
#15
Wandong Hong, Suhan Lin, Maddalena Zippi, Wujun Geng, Simon Stock, Vincent Zimmer, Chunfang Xu, Mengtao Zhou
BACKGROUND AND AIMS: Early prediction of disease severity of acute pancreatitis (AP) would be helpful for triaging patients to the appropriate level of care and intervention. The aim of the study was to develop a model able to predict Severe Acute Pancreatitis (SAP). METHODS: A total of 647 patients with AP were enrolled. The demographic data, hematocrit, High-Density Lipoprotein Cholesterol (HDL-C) determinant at time of admission, Blood Urea Nitrogen (BUN), and serum creatinine (Scr) determinant at time of admission and 24 hrs after hospitalization were collected and analyzed statistically...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904257/prognostic-significance-of-blood-urea-nitrogen-in-acute-ischemic-stroke
#16
Shoujiang You, Danni Zheng, Chongke Zhong, Xianhui Wang, Weiting Tang, Liqin Sheng, Cheng Zheng, Yongjun Cao, Chun-Feng Liu
BACKGROUND: Prior studies have shown an association between high blood urea nitrogen (BUN) and an elevated risk of mortality in heart failure patients, but data on the prognostic significance of BUN and other markers of kidney function in acute ischemic stroke (AIS) patients are sparse.Methods and Results:A total of 3,355 AIS patients were enrolled from December 2013 to May 2014, across 22 hospitals. Admission BUN was divided into quartiles (Q1, <4.39 mmol/L; Q2, ≥4.39 and <5...
September 12, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28895768/protective-effects-of-taurine-against-renal-ischemia-reperfusion-injury-in-rats-by-inhibition-of-gelatinases-mmp-2-and-mmp-9-and-p38-mitogen-activated-protein-kinase-signaling
#17
Z Cavdar, C Ural, A Celik, S Arslan, G Terzioglu, S Ozbal, S Yildiz, U B Ergur, E Guneli, T Camsari, G Akdogan
Dysregulated expression of matrix metalloproteinases (MMPs) is closely associated with the pathogenesis of renal ischemia/reperfusion injury (I/R). The production of excessive reactive oxygen species (ROS) causes tissue damage. Increased ROS production causes activation of p38 mitogen-activated protein kinase (MAPK) signaling, which participates in gene regulation of MMPs, especially MMP-2 and MMP-9 (gelatinases). Taurine (2-aminoethanesulfonic acid) in mammalian cells functions in bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, membrane stabilization, and antioxidation, antiinflammatory, and antiapoptotic action...
September 12, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28891516/effects-of-donepezil-on-liver-and-kidney-functions-for-the-treatment-of-alzheimer-s%C3%A2-disease
#18
Zübeyde Erbayraktar, Ahmet Evlice, Görsev Yener, N Nuray Ulusu
Aim of the present study is to investigate the effects of medication with donepezil (acetylcholinesterase inhibitor) on the liver and kidney function in Alzheimer's disease (AD) and to compare the effects of donepezil medication during short (one month) and long term (six years) follow-ups. We evaluated female and male patients from Cukurova [42 AD patients; short term (5 mg/day)] and Dokuz Eylul [68 AD patients; long term (10 mg/day)] University Hospital. The results compared with the geriatric population without dementia in other words who are not in medication with donepezil...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28888080/tg18-management-strategies-for-gallbladder-drainage-in-patients-with-acute-cholecystitis-updated-tokyo-guidelines-2018-with-videos
#19
Yasuhisa Mori, Takao Itoi, Todd H Baron, Tadahiro Takada, Steven M Strasberg, Henry A Pitt, Tomohiko Ukai, Satoru Shikata, Yoshinori Noguchi, Anthony Yuen Bun Teoh, Myung-Hwan Kim, Horacio J Asbun, Itaru Endo, Masamichi Yokoe, Fumihiko Miura, Kohji Okamoto, Kenji Suzuki, Akiko Umezawa, Yukio Iwashita, Taizo Hibi, Go Wakabayashi, Ho-Seong Han, Yoo-Seok Yoon, In-Seok Choi, Tsann-Long Hwang, Miin-Fu Chen, O James Garden, Harjit Singh, Kui-Hin Liau, Wayne Shih-Wei Huang, Dirk Joan Gouma, Giulio Belli, Christos Dervenis, Eduardo de Santibañes, Mariano Eduardo Giménez, John Albert Windsor, Wan Yee Lau, Daniel Cherqui, Palepu Jagannath, Avinash Nivritti Supe, Keng-Hao Liu, Cheng-Hsi Su, Daniel J Deziel, Xiao-Ping Chen, Sheung Tat Fan, Chen-Guo Ker, Eduard C Jonas, Robert Padbury, Shuntaro Mukai, Goro Honda, Atsushi Sugioka, Koji Asai, Ryota Higuchi, Keita Wada, Masahiro Yoshida, Toshihiko Mayumi, Koichi Hirata, Yoshinobu Sumiyama, Kazuo Inui, Masakazu Yamamoto
Since the publication of the Tokyo Guidelines in 2007 and their revision in 2013, appropriate management for acute cholecystitis has been more clearly established. Since the last revision, several manuscripts, especially for alternative endoscopic techniques, have been reported; therefore, additional evaluation and refinement of the 2013 Guidelines is required. We describe a standard drainage method for surgically high-risk patients with acute cholecystitis and the latest developed endoscopic gallbladder drainage techniques described in the updated Tokyo Guidelines 2018 (TG18)...
September 9, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28887962/a-simple-compact-low-cost-highly-efficient-thermometer-based-on-green-fluorescence-of-er-3-yb-3-codoped-nayf4-microcrystals
#20
Ning Yuan, Hong-Xue Sun, Dan-Dan Ju, Da-Yu Liu, Zi-Bo Zhang, Wing-Han Wong, Feng Song, Dao-Yin Yu, Edwin Yue-Bun Pun, De-Long Zhang
We developed a highly efficient optical thermometer based on intensity ratio of upconversion green fluorescence of Er(3+)/Yb(3+)-codoped NaYF4 microcrystals. The sensor consists simply of a 980nm laser diode, one narrow-band interference filter, two lenses, one Si-photocell and one multimeter, while being without use of spectrometer and additional electronics. The device not only has a simple, compact structure (hence a low cost), but also displays highly efficient sensing performance, characterized by large signal-to-noise ratio due to strong fluorescence intensity, high thermal resolution and sensitivity, which have the values 1...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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