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stent AND Zn

Patrick K Bowen, Jan-Marten Seitz, Roger J Guillory, Jacob P Braykovich, Shan Zhao, Jeremy Goldman, Jaroslaw W Drelich
Special high grade zinc and wrought zinc-aluminum (Zn-Al) alloys containing up to 5.5 wt % Al were processed, characterized, and implanted in rats in search of a new family of alloys with possible applications as bioabsorbable endovascular stents. These materials retained roll-induced texture with an anisotropic distribution of the second-phase Al precipitates following hot-rolling, and changes in lattice parameters were observed with respect to Al content. Mechanical properties for the alloys fell roughly in line with strength (190-240 MPa yield strength; 220-300 MPa ultimate tensile strength) and elongation (15-30%) benchmarks, and favorable elastic ranges (0...
January 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Jialin Niu, Zibo Tang, Hua Huang, Jia Pei, Hua Zhang, Guangyin Yuan, Wenjiang Ding
Zn-based alloys have been viewed as new potential materials for biodegradable implants, such as cardiovascular stents, mainly in consideration of their lower corrosion rate when compared with that of Mg alloys. In this study we developed a new Zinc-4wt.%Copper (Zn-4Cu) alloy as a biodegradable material. Hot extrusion was applied to Zn-4Cu to refine the microstructure and consequently improve its mechanical properties and corrosion resistance. After extrusion, dendritic CuZn5 phases were broken and distributed along the extrusion direction...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Jing Liu, Bo Zheng, Pei Wang, Xingang Wang, Bin Zhang, Qiuping Shi, Tingfei Xi, Ming Chen, Shaokang Guan
Bioabsorbable magnesium alloys are becoming prominent as temporary functional implants, as they avoid the risks generated by permanent metallic implants such as persistent inflammation and late restenosis. Nevertheless, the overfast corrosion of Mg alloys under physiological conditions hinders their wider application as medical implant materials. Here we investigate a simple one-step process to introduce a cross-linked 3-amino-propyltrimethoxysilane (APTES) silane physical barrier layer on the surface of Mg-Zn-Y-Nd alloys prior to electrostatic spraying with rapamycin-eluting poly(lactic-co-glycolic acid) (PLGA) layer...
July 20, 2016: ACS Applied Materials & Interfaces
Jun Ma, Nan Zhao, Donghui Zhu
Bioabsorbable metal zinc (Zn) is a promising new generation of implantable scaffold for cardiovascular and orthopedic applications. In cardiovascular stent applications, zinc ion (Zn(2+)) will be gradually released into the surrounding vascular tissues from such Zn-containing scaffolds after implantation. However, the interactions between vascular cells and Zn(2+) are still largely unknown. We explored the short-term effects of extracellular Zn(2+) on human smooth muscle cells (SMCs) up to 24 h, and an interesting biphasic effect of Zn(2+) was observed...
2016: Scientific Reports
Patrick K Bowen, Emily R Shearier, Shan Zhao, Roger J Guillory, Feng Zhao, Jeremy Goldman, Jaroslaw W Drelich
Metallic stents are used to promote revascularization and maintain patency of plaqued or damaged arteries following balloon angioplasty. To mitigate the long-term side effects associated with corrosion-resistant stents (i.e., chronic inflammation and late stage thrombosis), a new generation of so-called "bioabsorbable" stents is currently being developed. The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding. Research spanning the last two decades has focused on biodegradable polymeric, iron-based, and magnesium-based stent materials...
May 2016: Advanced Healthcare Materials
E Mostaed, M Sikora-Jasinska, A Mostaed, S Loffredo, A G Demir, B Previtali, D Mantovani, R Beanland, M Vedani
The search for a degradable metal simultaneously showing mechanical properties equal or higher to that of stainless steel and uniform degradation is still an open challenge. Several magnesium-based alloys have been studied, but their degradation rate has proved to be too fast and rarely homogeneous. Fe-based alloys show appropriate mechanical properties but very low degradation rate. In the present work, four novel Zn-Mg and two Zn-Al binary alloys were investigated as potential biodegradable materials for stent applications...
July 2016: Journal of the Mechanical Behavior of Biomedical Materials
Wenjiang Ding
In recent years, biodegradable magnesium alloys emerge as a new class of biomaterials for tissue engineering and medical devices. Deploying biodegradable magnesium-based materials not only avoids a second surgical intervention for implant removal but also circumvents the long-term foreign body effect of permanent implants. However, these materials are often subjected to an uncontrolled and fast degradation, acute toxic responses and rapid structural failure presumably due to a localized, too rapid corrosion process...
June 2016: Regenerative Biomaterials
Patrick K Bowen, Roger J Guillory, Emily R Shearier, Jan-Marten Seitz, Jaroslaw Drelich, Martin Bocks, Feng Zhao, Jeremy Goldman
Although corrosion resistant bare metal stents are considered generally effective, their permanent presence in a diseased artery is an increasingly recognized limitation due to the potential for long-term complications. We previously reported that metallic zinc exhibited an ideal biocorrosion rate within murine aortas, thus raising the possibility of zinc as a candidate base material for endovascular stenting applications. This study was undertaken to further assess the arterial biocompatibility of metallic zinc...
November 1, 2015: Materials Science & Engineering. C, Materials for Biological Applications
Yunan Yue, Lili Wang, Nuo Yang, Jinglin Huang, Licheng Lei, Huiming Ye, Lihui Ren, Shuixiang Yang
OBJECTIVES: To access the biocompatibility, effectiveness, and safety of biodegradable magnesium (Mg) alloy stent (BMAS) in the coronary artery and femoral artery. BACKGROUND: Atherosclerosis is a lesion of cardiovascular system, including the diseases in heart and blood vessels. METHODS: The aluminum (Al) and zinc (Zn)-based BMAS was designed by cold drawing methods. Forty healthy immunized mongrel dogs were randomly divided into 8 groups...
August 2015: Journal of Interventional Cardiology
Jan-Marten Seitz, Martin Durisin, Jeremy Goldman, Jaroslaw W Drelich
Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures...
September 16, 2015: Advanced Healthcare Materials
Lin Mao, Li Shen, Jiahui Chen, Yu Wu, Minsuk Kwak, Yao Lu, Qiong Xue, Jia Pei, Lei Zhang, Guangyin Yuan, Rong Fan, Junbo Ge, Wenjiang Ding
Magnesium (Mg) alloys have revolutionized the application of temporary load-bearing implants as they meet both engineering and medical requirements. However, rapid degradation of Mg alloys under physiological conditions remains the major obstacle hindering the wider use of Mg-based implants. Here we developed a simple method of preparing a nanoscale MgF2 film on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to reduce the corrosion rate as well as improve the biological response. The corrosion rate of JDBM alloy exposed to artificial plasma is reduced by ∼20% from 0...
March 11, 2015: ACS Applied Materials & Interfaces
T Y Nguyen, A F Cipriano, Ren-Guo Guan, Zhan-Yong Zhao, Huinan Liu
Magnesium (Mg) alloy is an attractive class of metallic biomaterial for cardiovascular applications due to its biodegradability and mechanical properties. In this study, we investigated the degradation in blood, thrombogenicity, and cytocompatibility of Magnesium-Zinc-Strontium (Mg-Zn-Sr) alloys, specifically four Mg-4 wt % Zn-xSr (x = 0.15, 0.5, 1, and 1.5 wt %) alloys, together with pure Mg control and relevant reference materials for cardiovascular applications. Human whole blood and platelet rich plasma (PRP) were used as the incubation media to investigate the degradation behavior of the Mg-Zn-Sr alloys...
September 2015: Journal of Biomedical Materials Research. Part A
Fei Liu, Chenxin Chen, Jialin Niu, Jia Pei, Hua Zhang, Hua Huang, Guangyin Yuan
In this study, through a combination of hot extrusion, cold rolling and drawing, three Mg alloys, Mg-Nd-Zn-Zr (abbr. JDBM), AZ31 and WE43, were successfully fabricated into the high-quality micro-tubes with 3.00mm outer diameter and 180μm thickness for biodegradable stents. This processing method overcame the shortcoming of the poor workability of Mg alloys and could be applied to fabricate sufficiently long tubes with low dimensional errors within 2.8%. Microstructure observation demonstrated that the as-annealed JDBM, AZ31 and WE43 micro-tubes had more uniformly distributed grains with an average size of 10...
March 2015: Materials Science & Engineering. C, Materials for Biological Applications
Ehsan Mostaed, Maurizio Vedani, Mazdak Hashempour, Massimiliano Bestetti
Equal channel angular pressing (ECAP) was performed on ZK60 alloy and pure Mg in the temperature range 150-250 °C. A significant grain refinement was detected after ECAP, leading to an ultrafine grain size (UFG) and enhanced formability during extrusion process. Comparing to conventional coarse grained samples, fracture elongation of pure Mg and ZK60 alloy were significantly improved by 130% and 100%, respectively, while the tensile strength remained at high level. Extrusion was performed on ECAP processed billets to produce small tubes (with outer/inner diameter of 4/2...
2014: Biomatter
Lin Mao, Guangyin Yuan, Jialin Niu, Yang Zong, Wenjiang Ding
In this paper, Mg-Nd-Zn-Zr alloy (denoted as JDBM) coated with hydrofluoric acid (HF) chemical conversion film (MgF2) was researched as a potential biodegradable cardiovascular stent material. The microstructures, in vitro degradation and biocompatibility were investigated. The field emission scanning electron microscopy (FE-SEM) and X-ray photoelectron spectroscopy (XPS) showed that a compact MgF2 film was formed on the surface of JDBM. The corrosion rate decreased in artificial plasma from 0.337 to 0.253 mm·y(-1) and the electrochemical measurement demonstrated that the corrosion resistance of JDBM alloy could be obviously improved due to the protective MgF2 film on the surface of the substrate...
January 1, 2013: Materials Science & Engineering. C, Materials for Biological Applications
Emily K Walker, Eric A Nauman, Jean Paul Allain, Lia A Stanciu
Vascular stents that can biodegrade and disappear in time have been reported as a promising solution to the problems of late-stent thrombosis and in-stent restenosis. Iron alloys in particular have many advantages in terms of cytocompatibility and mechanical properties. Despite mechanical behavior and biocompatibility studies, little attention has been given to the thrombogenic potential of these stents. This article presents the first study that aims to close this gap by addressing the hemocompatibility of resorbable iron-based alloys and composites in an in vitro porcine blood model...
June 2015: Journal of Biomedical Materials Research. Part A
Ehsan Mostaed, Maurizio Vedani, Mazdak Hashempour, Massimiliano Bestetti
Equal channel angular pressing (ECAP) was performed on ZK60 alloy and pure Mg in the temperature range 150-250 °C. A significant grain refinement was detected after ECAP leading to an ultrafine grain size (UFG) and enhanced formability during extrusion process. Comparing to conventional coarse grained samples, fracture elongation of pure Mg and ZK60 alloy were significantly improved by 130% and 100%, respectively, while the tensile strength remained at high level. Extrusion was performed on ECAP processed billets to produce small tubes (with outer/inner diameter of 4/2...
February 21, 2014: Biomatter
Maurício S Ribeiro, Renata Dellalibera-Joviliano, Christiane Becari, Felipe Roberti Teixeira, Paula Vasconcelos Araujo, Carlos E Piccinato, Cesar Presto Campos, Paulo Roberto B Evora, Edwaldo E Joviliano
BACKGROUND: The kallikrein-kinin system (KKS) has several direct and indirect effects on cells and cellular mediators involved in the inflammatory process. Studies about inflammation on percutaneous transluminal angioplasty with stent (PTA/stent) to treat peripheral arterial disease (PAD) in humans are scarce. The matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing endopeptidases expressed in various cells and tissues such as fibroblasts, inflammatory cells, and, smooth muscle cells...
May 2014: Annals of Vascular Surgery
Jian Zhang, Ni Kong, Jialin Niu, Yongjuan Shi, Haiyan Li, Yue Zhou, Guangyin Yuan
Fluoride treatment is a commonly used technique or pre-treatment to optimize the degradation kinetic and improve the biocompatibility of magnesium-based implant. The influence of changed surface properties and degradation kinetics on subsequent protein adsorption and cytocompatibility is critical to understand the biocompatibility of the implant. In this study, a patent magnesium alloy Mg-Nd-Zn-Zr alloy (JDBM) designed for cardiovascular stent application was treated by immersion in hydrofluoric acid. A 1.5 μm thick MgF2 layer was prepared...
March 2014: Journal of Materials Science. Materials in Medicine
Yigang Chen, Jun Yan, Changli Zhao, Shaoxiang Zhang, Song Yu, Zigang Wang, Xiaohu Wang, Xiaonong Zhang, Qi Zheng
There is a great clinical need for biodegradable bile duct stents. Biodegradable stents made of an Mg-6Zn alloy were investigated in both vivo animal experiment and in vitro cell experiments. During the in vivo experiments, blood biochemical tests were performed to determine serum magnesium, serum creatinine (CREA), blood urea nitro-gen (BUN), serum lipase (LPS), total bilirubin (TB) and glutamic-pyruvic transaminase (GPT) levels. Moreover, tissue samples of common bile duct (CBD), liver and kidney were taken for histological evaluation...
February 2014: Journal of Materials Science. Materials in Medicine
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