keyword
MENU ▼
Read by QxMD icon Read
search

stent AND Zn

keyword
https://www.readbyqxmd.com/read/29538391/in-vitro-study-of-the-inflammatory-cells-response-to-biodegradable-mg-based-alloy-extract
#1
Liang Jin, Jing Wu, Guangyin Yuan, Tongxin Chen
Biodegradable Mg-based alloys have shown great potential as bone fixation devices or vascular stents. As implant biomaterials, the foreign body reaction (FBR) is an important issue to be studied, where the inflammatory cells play a key role. Here, we used two inflammatory cell lines i.e. THP-1 cells and THP-1 macrophages, to evaluate the effect of Mg-Nd-Zn-Zr alloy (denoted as JDBM) extracts on cell viability, death modes, cell cycle, phagocytosis, differentiation, migration and inflammatory response. The results showed that high-concentration extract induced necrosis and complete damage of cell function...
2018: PloS One
https://www.readbyqxmd.com/read/29530821/zinc-based-alloys-for-degradable-vascular-stent-applications
#2
REVIEW
Ehsan Mostaed, Malgorzata Sikora-Jasinska, Jaroslaw W Drelich, Maurizio Vedani
The search for biodegradable metals with mechanical properties equal or higher to those of currently used permanent biomaterials, such as stainless steels, cobalt chromium and titanium alloys, desirable in vivo degradation rate and uniform corrosion is still an open challenge. Magnesium (Mg), iron (Fe) and zinc (Zn)-based alloys have been proposed as biodegradable metals for medical applications. Over the last two decades, extensive research has been done on Mg and Fe. Fe-based alloys show appropriate mechanical properties, but their degradation rate is an order of magnitude below the benchmark value...
March 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29519445/novel-high-strength-low-alloys-zn-mg-0-1wt-mg-and-their-arterial-biodegradation
#3
Hualan Jin, Shan Zhao, Roger Guillory, Patrick K Bowen, Zhiyong Yin, Adam Griebel, Jeremy Schaffer, Elisha J Earley, Jeremy Goldman, Jaroslaw W Drelich
It is still an open challenge to find a biodegradable metallic material exhibiting sufficient mechanical properties and degradation behavior to serve as an arterial stent. In this study, Zn-Mg alloys of 0.002 (Zn-002Mg), 0.005 (Zn-005Mg) and 0.08wt% Mg (Zn-08Mg) content were cast, extruded and drawn to 0.25mm diameter, and evaluated as potential biodegradable stent materials. Structural analysis confirmed formation of Mg2 Zn11 intermetallic in all three alloys with the average grain size decreasing with increasing Mg content...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29369807/the-degradation-and-transport-mechanism-of-a-mg-nd-zn-zr-stent-in-rabbit-common-carotid-artery-a-20-month-study
#4
Jian Zhang, Haiyan Li, Wu Wang, Hua Huang, Jia Pei, Haiyun Qu, Guangyin Yuan, Yongdong Li
Mg-based stent is a promising candidate of the next generation fully degradable vascular stents. The latest progress includes the CE approval of the Magmaris ® WE43 based drug eluting stent. However, so far, the long term (more than 1 year implantation) in vivo degradation and the physiological effects caused by the degradation products were still unclear. In this study, a 20 month observation was carried out after the bare Mg-Nd-Zn-Zr (abbr. JDBM) stent prototype was implanted into the common carotid artery of New Zealand white rabbit in order to evaluate its safety, efficacy and especially degradation behavior...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29068537/anti-fibrotic-function-of-cu-bearing-stainless-steel-for-reducing-recurrence-of-urethral-stricture-after-stent-implantation
#5
Jing Zhao, Ling Ren, Meixia Liu, Tong Xi, Bingchun Zhang, Ke Yang
Recurrent stenosis is the main reason inducing the failure of urethral stricture treatment. Our previous study has found that the 316L type Cu bearing stainless steel (316L-Cu SS) showed antimicrobial activity and anti-encrustation performance when it was used for relieving urethral obstructer. However, whether it can reduce the occurrence of fibrosis or not, we need further investigation to compare the cellular and molecular responses of human urethral scar fibroblast cells (USFCs) on 316L-Cu SS and medical grade 316L stainless (316L SS, as a control)...
October 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28866142/in-vitro-and-in-vivo-degradation-of-rapamycin-eluting-mg-nd-zn-zr-alloy-stents-in-porcine-coronary-arteries
#6
Yongjuan Shi, Lei Zhang, Jiahui Chen, Jian Zhang, Feng Yuan, Li Shen, Chenxin Chen, Jia Pei, Zhonghua Li, Jinyun Tan, Guangyin Yuan
In this work, rapamycin-eluting poly (d, l-lactic acid) coating (PDLLA/RAPA) was prepared on biodegradable Mg-Nd-Zn-Zr alloy (JDBM) for both in vitro and in vivo investigation of the degradation behaviors of the magnesium alloy stent platform. Electrochemical tests and hydrogen evolution test demonstrated significant in vitro protection of the polymeric coating against magnesium degradation both in short and long term. The 3-month in vivo study on the RAPA-eluting JDBM stent implanted into porcine coronary arteries confirmed its favorable safety, and in the meanwhile revealed similar neointima proliferation compared to the second generation DES Firebird 2 with no occurrence of adverse complications...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28780463/arginine-leucine-based-poly-ester-urea-urethane-coating-for-mg-zn-y-nd-alloy-in-cardiovascular-stent-applications
#7
Jing Liu, Pei Wang, Chih-Chang Chu, Tingfei Xi
Selected from the family of self-designed biodegradable amino acid-based poly (ester urea urethane) (AA-PEUU) pseudo-protein biomaterials, arginine-leucine based poly (ester urea urethane)s (Arg-Leu-PEUUs) were used as protective and bio-functional coatings for bio-absorbable magnesium alloy MgZnYNd in cardiovascular stent applications. Comparing with poly (glycolide-co-lactide) (PLGA) coating, the Arg-Leu-PEUU coating had stronger bonding strength with the substrate; in vitro electrochemical and long-term immersion results verified a significantly better corrosion resistance...
November 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28532901/long-term-surveillance-of-zinc-implant-in-murine-artery-surprisingly-steady-biocorrosion-rate
#8
Adam J Drelich, Shan Zhao, Roger J Guillory, Jaroslaw W Drelich, Jeremy Goldman
Metallic zinc implanted into the abdominal aorta of rats out to 6months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions...
August 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28531993/fabrication-mechanical-properties-and-in-vitro-degradation-behavior-of-newly-developed-znag-alloys-for-degradable-implant-applications
#9
M Sikora-Jasinska, E Mostaed, A Mostaed, R Beanland, D Mantovani, M Vedani
Zn and Zn-based alloys have been recognized as highly promising biodegradable materials for orthopedic implants and cardiovascular stents, due to their proved biocompatibility and, more importantly, lower corrosion rates compared to Mg alloys. However, pure Zn has poor mechanical properties. In this study, Ag is used as a promising alloying element to improve the mechanical properties of the Zn matrix as well as its biocompatibility and antibacterial properties. Accordingly, we design three ZnAg alloys with Ag content ranging from 2...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28499166/potential-biodegradable-zn-cu-binary-alloys-developed-for-cardiovascular-implant-applications
#10
Zibo Tang, Jialin Niu, Hua Huang, Hua Zhang, Jia Pei, Jingmin Ou, Guangyin Yuan
Binary Zn-Cu alloy system is developed as potential biodegradable materials for cardiovascular implant application. The microstructure, tensile properties, in vitro corrosion behavior, cytotoxicity and antibacterial property of as-extruded Zn-xCu (x=1, 2, 3, and 4wt%) alloys are investigated systematically. It shows that as Cu content increases more CuZn5 phase precipitates. After extrusion, the CuZn5 phases are broken and the grains of Zn-xCu alloys are refined. Tensile test shows that Cu addition could significantly improve the mechanical properties of Zn-xCu alloys...
August 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28130871/evaluation-of-wrought-zn-al-alloys-1-3-and-5-wt-al-through-mechanical-and-in-vivo-testing-for-stent-applications
#11
Patrick K Bowen, Jan-Marten Seitz, Roger J Guillory, Jacob P Braykovich, Shan Zhao, Jeremy Goldman, Jaroslaw W Drelich
Special high grade zinc and wrought zinc-aluminum (Zn-Al) alloys containing up to 5.5 wt % Al were processed, characterized, and implanted in rats in search of a new family of alloys with possible applications as bioabsorbable endovascular stents. These materials retained roll-induced texture with an anisotropic distribution of the second-phase Al precipitates following hot-rolling, and changes in lattice parameters were observed with respect to Al content. Mechanical properties for the alloys fell roughly in line with strength (190-240 MPa yield strength; 220-300 MPa ultimate tensile strength) and elongation (15-30%) benchmarks, and favorable elastic ranges (0...
January 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27612729/research-on-a-zn-cu-alloy-as-a-biodegradable-material-for-potential-vascular-stents-application
#12
Jialin Niu, Zibo Tang, Hua Huang, Jia Pei, Hua Zhang, Guangyin Yuan, Wenjiang Ding
Zn-based alloys have been viewed as new potential materials for biodegradable implants, such as cardiovascular stents, mainly in consideration of their lower corrosion rate when compared with that of Mg alloys. In this study we developed a new Zinc-4wt.%Copper (Zn-4Cu) alloy as a biodegradable material. Hot extrusion was applied to Zn-4Cu to refine the microstructure and consequently improve its mechanical properties and corrosion resistance. After extrusion, dendritic CuZn5 phases were broken and distributed along the extrusion direction...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27331417/enhanced-in-vitro-and-in-vivo-performance-of-mg-zn-y-nd-alloy-achieved-with-aptes-pretreatment-for-drug-eluting-vascular-stent-application
#13
Jing Liu, Bo Zheng, Pei Wang, Xingang Wang, Bin Zhang, Qiuping Shi, Tingfei Xi, Ming Chen, Shaokang Guan
Bioabsorbable magnesium alloys are becoming prominent as temporary functional implants, as they avoid the risks generated by permanent metallic implants such as persistent inflammation and late restenosis. Nevertheless, the overfast corrosion of Mg alloys under physiological conditions hinders their wider application as medical implant materials. Here we investigate a simple one-step process to introduce a cross-linked 3-amino-propyltrimethoxysilane (APTES) silane physical barrier layer on the surface of Mg-Zn-Y-Nd alloys prior to electrostatic spraying with rapamycin-eluting poly(lactic-co-glycolic acid) (PLGA) layer...
July 20, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27248371/bioabsorbable-zinc-ion-induced-biphasic-cellular-responses-in-vascular-smooth-muscle-cells
#14
Jun Ma, Nan Zhao, Donghui Zhu
Bioabsorbable metal zinc (Zn) is a promising new generation of implantable scaffold for cardiovascular and orthopedic applications. In cardiovascular stent applications, zinc ion (Zn(2+)) will be gradually released into the surrounding vascular tissues from such Zn-containing scaffolds after implantation. However, the interactions between vascular cells and Zn(2+) are still largely unknown. We explored the short-term effects of extracellular Zn(2+) on human smooth muscle cells (SMCs) up to 24 h, and an interesting biphasic effect of Zn(2+) was observed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27094868/biodegradable-metals-for-cardiovascular-stents-from-clinical-concerns-to-recent-zn-alloys
#15
REVIEW
Patrick K Bowen, Emily R Shearier, Shan Zhao, Roger J Guillory, Feng Zhao, Jeremy Goldman, Jaroslaw W Drelich
Metallic stents are used to promote revascularization and maintain patency of plaqued or damaged arteries following balloon angioplasty. To mitigate the long-term side effects associated with corrosion-resistant stents (i.e., chronic inflammation and late stage thrombosis), a new generation of so-called "bioabsorbable" stents is currently being developed. The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding. Research spanning the last two decades has focused on biodegradable polymeric, iron-based, and magnesium-based stent materials...
May 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27062241/novel-zn-based-alloys-for-biodegradable-stent-applications-design-development-and-in-vitro-degradation
#16
E Mostaed, M Sikora-Jasinska, A Mostaed, S Loffredo, A G Demir, B Previtali, D Mantovani, R Beanland, M Vedani
The search for a degradable metal simultaneously showing mechanical properties equal or higher to that of stainless steel and uniform degradation is still an open challenge. Several magnesium-based alloys have been studied, but their degradation rate has proved to be too fast and rarely homogeneous. Fe-based alloys show appropriate mechanical properties but very low degradation rate. In the present work, four novel Zn-Mg and two Zn-Al binary alloys were investigated as potential biodegradable materials for stent applications...
July 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27047673/opportunities-and-challenges-for-the-biodegradable-magnesium-alloys-as-next-generation-biomaterials
#17
REVIEW
Wenjiang Ding
In recent years, biodegradable magnesium alloys emerge as a new class of biomaterials for tissue engineering and medical devices. Deploying biodegradable magnesium-based materials not only avoids a second surgical intervention for implant removal but also circumvents the long-term foreign body effect of permanent implants. However, these materials are often subjected to an uncontrolled and fast degradation, acute toxic responses and rapid structural failure presumably due to a localized, too rapid corrosion process...
June 2016: Regenerative Biomaterials
https://www.readbyqxmd.com/read/26249616/metallic-zinc-exhibits-optimal-biocompatibility-for-bioabsorbable-endovascular-stents
#18
Patrick K Bowen, Roger J Guillory, Emily R Shearier, Jan-Marten Seitz, Jaroslaw Drelich, Martin Bocks, Feng Zhao, Jeremy Goldman
Although corrosion resistant bare metal stents are considered generally effective, their permanent presence in a diseased artery is an increasingly recognized limitation due to the potential for long-term complications. We previously reported that metallic zinc exhibited an ideal biocorrosion rate within murine aortas, thus raising the possibility of zinc as a candidate base material for endovascular stenting applications. This study was undertaken to further assess the arterial biocompatibility of metallic zinc...
November 1, 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26224391/effectiveness-of-biodegradable-magnesium-alloy-stents-in-coronary-artery-and-femoral-artery
#19
Yunan Yue, Lili Wang, Nuo Yang, Jinglin Huang, Licheng Lei, Huiming Ye, Lihui Ren, Shuixiang Yang
OBJECTIVES: To access the biocompatibility, effectiveness, and safety of biodegradable magnesium (Mg) alloy stent (BMAS) in the coronary artery and femoral artery. BACKGROUND: Atherosclerosis is a lesion of cardiovascular system, including the diseases in heart and blood vessels. METHODS: The aluminum (Al) and zinc (Zn)-based BMAS was designed by cold drawing methods. Forty healthy immunized mongrel dogs were randomly divided into 8 groups...
August 2015: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/26172399/recent-advances-in-biodegradable-metals-for-medical-sutures-a-critical-review
#20
REVIEW
Jan-Marten Seitz, Martin Durisin, Jeremy Goldman, Jaroslaw W Drelich
Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures...
September 16, 2015: Advanced Healthcare Materials
keyword
keyword
48907
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"