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Acute promyelocytic leukemia

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https://www.readbyqxmd.com/read/28075463/expression-of-the-promyelocytic-leukemia-protein-without-the-nuclear-localization-signal-as-a-novel-diagnostic-marker-for-acute-promyelocytic-leukemia
#1
Ting Xu, Xiao-Qun Yang, Kai-Ling Jiang, Hui Wang, Peng-Peng Ma, Liang Zhong, Bei-Zhong Liu
Promyelocytic leukemia-retinoic acid receptor α (PML-RARα) is a fusion protein generated by the t(15;17)(q22;q12) translocation associated with acute promyelocytic leukemia (APL). PML-RARα is cleaved by neutrophil elastase, an early myeloid-specific serine protease, leading to translocation of the nuclear localization signal (NLS) of the PML protein to the N-terminal of RARα, and the mutational product PML(NLS-). The present study was designed to analyze the role of the NLS in mediating PML transport into the nucleus and to evaluate the value of measuring NLS translocation in the early diagnosis of APL...
January 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28074065/hdac3-activity-is-required-for-initiation-of-leukemogenesis-in-acute-promyelocytic-leukemia
#2
P Mehdipour, F Santoro, O A Botrugno, M Romanenghi, C Pagliuca, G M Matthews, R W Johnstone, S Minucci
Leukemia accepted article preview online, 11 January 2017. doi:10.1038/leu.2017.3.
January 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28070163/development-of-reverse-transcription-loop-mediated-isothermal-amplification-for-simple-and-rapid-detection-of-promyelocytic-leukemia-retinoic-acid-receptor-%C3%AE-mrna
#3
Yuki Hashimoto, Yuki Hatayama, Nao Kojima, Shota Morishita, Satoko Matsumoto, Yuzuru Hosoda, Ayako Hara, Toru Motokura
BACKGROUND: Acute promyelocytic leukemia (APL) is a disease characterized by expression of Promyelocytic Leukemia-Retinoic Acid Receptor α (PML-RARα) chimeric mRNA. Although APL is curable, early death due to hemorrhage is a major problem. Here, we report the development of a simple and rapid diagnostic method for APL based on reverse transcription loop-mediated isothermal amplification (RT-LAMP). METHODS: An RT-LAMP primer set was designed to detect three types of PML-RARα mRNA in a single reaction...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28070082/evaluation-of-structural-isomers-molecular-interactions-reactivity-descriptors-and-vibrational-analysis-of-tretinoin
#4
T Karthick, Poonam Tandon, Swapnil Singh
Tretinoin is known to be a pharmaceutical drug for treating acne vulgaris, keratosis pilaris, and acute promyelocytic leukemia. In order to reveal the possible conformers of tretinoin, the energies of all the conformers through rotational bonds have been evaluated by systematic rotor search analysis. The intramolecular interactions ranging from strong hydrogen bonds to weak van der Waals forces present in tretinoin have been distinguished with the help of electron density mapping and wavefunction analysis. The global reactivity descriptors and Fukui functions of tretinoin have been calculated and discussed...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28063140/regulatory-mechanism-and-functional-analysis-of-s100a9-in-acute-promyelocytic-leukemia-cells
#5
Yonglan Zhu, Fang Zhang, Shanzhen Zhang, Wanglong Deng, Huiyong Fan, Haiwei Wang, Ji Zhang
S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of S100A9 and its function involvement in APL. We used real-time quantitative PCR to determine whether PML/RARα affects the expression of S100A9 in NB4 and PR9 cells upon ATRA treatment. ChIP-based PCR and dual-luciferase reporter assay system were used to detect how PML/RARα and PU...
January 6, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28058104/severe-lower-limb-ischemia-by-massive-arterial-thrombosis-revealing-an-acute-myeloid-leukemia-needing-for-leg-amputation-clinical-and-emotional-aspects-related-to-the-communication-with-the-patient-and-his-family
#6
Paolo D'Angelo, Calogero Taormina, Clara Mosa, Floriana Di Marco, Fabrizio Valentino, Angela Trizzino, Paola Guadagna, Francesco Talarico
Large vessel thrombosis is a very rare clinical presentation of acute leukemia, generally associated with coagulopathy, usually characteristic of acute promyelocytic leukemia. A 13- year-old boy with a previously undiagnosed acute myeloid leukemia was referred to our hospital with acute ischemia of the right lower limb due to occlusion of the right external iliac artery, treated with emergency double surgical thromboembolectomy and chemotherapy. The thrombotic complication resulted in leg amputation. Now the boy is well in complete remission, with a good social integration and quality of life, 30 months after completing treatment...
November 17, 2016: Pediatric Reports
https://www.readbyqxmd.com/read/28053193/promyelocytic-extracellular-chromatin-exacerbates-coagulation-and-fibrinolysis-in-acute-promyelocytic-leukemia
#7
Muhua Cao, Tao Li, Zhangxiu He, Lixiu Wang, Xiaoyan Yang, Yan Kou, Lili Zou, Xue Dong, Valerie A Novakovic, Yayan Bi, Junjie Kou, Bo Yu, Shaohong Fang, Jinghua Wang, Jin Zhou, Jialan Shi
Despite routine treatment of unselected acute promyelocytic leukemia (APL) with all-trans-retinoic acid (ATRA), early death due to hemorrhage remains unacceptably common and the mechanism underlying this complication remains elusive. We have recently demonstrated that APL cells undergo a novel cell death program, termed ETosis, which involves release of extracellular chromatin. However, the role of promyelocytic extracellular chromatin in APL-associated coagulation remains unclear. Our objectives were to identify the novel role of ATRA-promoted extracellular chromatin in inducing a hypercoagulable and hyperfibrinolytic state in APL and to evaluate its interaction with fibrin and endothelial cells (ECs)...
January 4, 2017: Blood
https://www.readbyqxmd.com/read/28053092/histone-acetyltransferase-pcaf-is-required-for-all-trans-retinoic-acid-induced-granulocytic-differentiation-in-leukemia-cells
#8
Yoshitaka Sunami, Marito Araki, Shin Kan, Akihiro Ito, Yumi Hironaka, Misa Imai, Soji Morishita, Akimichi Ohsaka, Norio Komatsu
Differentiation therapy with all-trans retinoic acid (ATRA) improves the treatment outcome of acute promyelocytic leukemia (APL); however, the molecular mechanism by which ATRA induces granulocytic differentiation remains unclear. We previously reported that the inhibition of the NAD-dependent histone deacetylase (HDAC) SIRT2 induces granulocytic differentiation in leukemia cells, suggesting the involvement of protein acetylation in ATRA-induced leukemia cell differentiation. Herein, we showed that p300/CREB-binding protein-associated factor (PCAF), a histone acetyltransferase (HAT), is a prerequisite for ATRA-induced granulocytic differentiation in leukemia cells...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28052659/p15ink4b-loss-of-expression-by-promoter-hypermethylation-adds-to-leukemogenesis-and-confers-a-poor-prognosis-in-acute-promyelocytic-leukemia-patients
#9
Shahid M Baba, Niyaz A Azad, Zafar A Shah, Dil- Afroze, Arshad A Pandith, Aleem Jan, Sheikh A Aziz
Purpose: The p15Ink4b gene exerts its influence as an inhibitor of cyclin-dependent kinases and is frequently associated with hematological malignancies. Inactivation of this gene through DNA methylation has been found to be the most prevalent epigenetic alteration reported, with a high frequency in all FAB subtypes of AMLs, including APL. In this study, we investigated the prognostic significance of p15 gene promoter hypermethylation and its expression in APL patients of Kashmir (North India)...
December 5, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28039033/identification-of-an-irf-1-splicing-transcript-in-apl-cells-sharing-similar-transactivation-activity-of-the-full-length-one
#10
Yejiang Lou, Di Xia, Mengxia Yu, Jianhua Tong, Jie Jin
Interferon regulatory factor-1 (IRF-1) is a member of the interferon regulatory factor family. It acts as a transcriptional activator and plays a critical role in antiviral defense, immune response, cell growth regulation, apoptosis and cell differentiation. Deletions, mutations or aberrant splicing of IRF-1 would result in its functional inactivation, and closely related to the tumorigenesis. In this work, we identified an IRF-1 splicing transcript (IRF-1-s) in all-trans retinoic acid (ATRA)-treated acute promyelocytic leukemia (APL) cell line NB4 cells...
December 27, 2016: Gene
https://www.readbyqxmd.com/read/28035062/positive-feedback-loop-of-il-1%C3%AE-akt-rar%C3%AE-akt-signaling-mediates-oncogenic-property-of-rar%C3%AE-in-gastric-carcinoma
#11
Hong-Yue Ren, Fan Liu, Gui-Li Huang, Yu Liu, Jin-Xing Shen, Pan Zhou, Wen-Ming Liu, Dong-Yan Shen
Abnormal expression and function of retinoic acid receptor α (RARα) have been reported to be associated with various cancers including acute promyelocytic leukemia and hepatocellular carcinoma. However, the role and the mechanism of RARα in gastric carcinoma (GC) were unknown. Here, the expression of RARα was frequently elevated in human GC tissues and cell lines, and its overexpression was closely correlated with tumor size, lymph node metastasis and clinical stages in GC patients. Moreover, RARα overexpression was related with pathological differentiation...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28034863/huang-me-ye-yc-chen-sr-et-al-use-of-all-trans-retinoic-acid-in-the-treatment-of-acute-promyelocytic-leukemia-blood-1988-72-2-567-572
#12
(no author information available yet)
No abstract text is available yet for this article.
December 29, 2016: Blood
https://www.readbyqxmd.com/read/28031527/tumor-initiating-cells-of-breast-and-prostate-origin-show-alterations-in-the-expression-of-genes-related-to-iron-metabolism
#13
Zuzana Rychtarcikova, Sandra Lettlova, Veronika Tomkova, Vlasta Korenkova, Lucie Langerova, Ekaterina Simonova, Polina Zjablovskaja, Meritxell Alberich-Jorda, Jiri Neuzil, Jaroslav Truksa
The importance of iron in the growth and progression of tumors has been widely documented. In this report, we show that tumor-initiating cells (TICs), represented by spheres derived from the MCF7 cell line, exhibit higher intracellular labile iron pool, mitochondrial iron accumulation and are more susceptible to iron chelation. TICs also show activation of the IRP/IRE system, leading to higher iron uptake and decrease in iron storage, suggesting that level of properly assembled cytosolic iron-sulfur clusters (FeS) is reduced...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28028527/from-conventional-therapy-toward-microrna-based-therapy-in-acute-promyelocytic-leukemia
#14
REVIEW
Naeim Ehtesham, Mohammadreza Sharifi
Acute promyelocytic leukemia (APL) is a hematopoietic malignancy that is known with its special cytogenetic feature. Several studies have surveyed expression signature of microRNAs (miRNAs) in APL patients, especially patients who are treated with conventional therapy of this disease. Using miRNAs as diagnostic or prognostic biomarkers in various cancers has been widely studied. Currently, most studies are focusing on exploiting miRNAs as therapeutic tools, and promising progress has been achieved in this field...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28025581/pml-rara-associated-cooperating-mutations-belong-to-a-transcriptional-network-that-is-deregulated-in-myeloid-leukemias
#15
C Ronchini, A Brozzi, L Riva, L Luzi, A M Gruszka, G E M Melloni, E Scanziani, G Dharmalingam, M Mutarelli, V Belcastro, S Lavorgna, V Rossi, O Spinelli, A Biondi, A Rambaldi, F Lo-Coco, D di Bernardo, P G Pelicci
It has been shown that individual Acute Myeloid Leukemia (AML) patients are characterized by one of few initiating DNA mutations and 5-10 cooperating mutations not yet defined among hundreds identified by massive sequencing of AML genomes. We report an in vivo insertional mutagenesis screen for genes cooperating with one AML initiating mutations (PML-RARA, oncogene of acute promyelocytic leukemia, APL), which allowed identification of hundreds of genetic cooperators. The cooperators are mutated at low frequency in APL or AML patients but are always abnormally expressed in a cohort of 182 APLs and AMLs analyzed...
December 27, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28024465/-flt3-itd-mutation-in-newly-diagnosed-patients-with-acute-promyelocytic-leukemia
#16
Ben-Fa Gong, Ying Wang, Dong Lin, Hui Wei, Wei Li, Chun-Lin Zhou, Bing-Cheng Liu, Kai-Qi Liu, Guang-Ji Zhang, Yun-Tao Liu, Yan Li, Shu-Ning Wei, Xiao-Yuan Gong, Xing-Li Zhao, Shao-Wei Qiu, Run-Xia Gu, Ying-Chang Mi, Jian-Xiang Wang
OBJECTIVE: To evaluate the influence of FLT3-ITD mutation on long term survival of newly diagnosed patients with acute promyelocytic leukemia (APL). METHODS: Long term survival of 170 newly diagnosed APL patients was retrospective analyzed. Mutation rate of FLT3-ITD was assayed, and its influence on disease-free survival(DFS) or overall survival (OS) was analyzed. RESULTS: The mutation rate of FLT3-ITD in newly diagnosed patients with APL was 14...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28013226/disseminated-intravascular-coagulation
#17
Benjamin M Boral, Dennis J Williams, Leonard I Boral
OBJECTIVES: To provide a review of the definition, pathophysiology, differential diagnosis, and treatment of disseminated intravascular coagulation (DIC). METHODS: A case scenario and a review of the literature related to the pertinent facts concerning DIC are provided. RESULTS: DIC is a systemic pathophysiologic process and not a single disease entity, resulting from an overwhelming activation of coagulation that consumes platelets and coagulation factors and causes microvascular fibrin thrombi, which can result in multiorgan dysfunction syndrome from tissue ischemia...
December 24, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28013066/antileukemic-activity-of-an-arsenomolybdate-in-the-human-hl-60-and-u937-leukemia-cells
#18
Chunyan Li, Hongqian Cao, Jiaheng Sun, Rui Tian, Dongbei Li, Yanfei Qi, Wei Yang, Juan Li
The antileukemic activity, mechanisms and serum albumin interactions of an arsenomolybdate, K2Na[AsMo6O21(O2CCH2NH3)3]·6H2O (1), was evaluated in the human leukemia HL-60 and U937 cells. The results indicated that 1 could inhibit the proliferation of both leukemia cell lines in a dose-dependent manner with the 50% lethal concentration (IC50) value of 8.61μM for HL-60 and 14.50μM for U937 at 24h, compare to the positive controls, all-trans retinoic acid (ATRA) with IC50 value of 20.76μM and 14.85μM,and As2O3 with IC50 value of 6...
December 16, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28007728/gallagher-r-collins-s-trujillo-j-et-al-characterization-of-the-continuous-differentiating-myeloid-cell-line-hl-60-from-a-patient-with-acute-promyelocytic-leukemia-blood-1979-54-3-713-733
#19
https://www.readbyqxmd.com/read/28007179/cellular-arsenic-transport-pathways-in-mammals
#20
REVIEW
Barbara A Roggenbeck, Mayukh Banerjee, Elaine M Leslie
Natural contamination of drinking water with arsenic results in the exposure of millions of people world-wide to unacceptable levels of this metalloid. This is a serious global health problem because arsenic is a Group 1 (proven) human carcinogen and chronic exposure is known to cause skin, lung, and bladder tumors. Furthermore, arsenic exposure can result in a myriad of other adverse health effects including diseases of the cardiovascular, respiratory, neurological, reproductive, and endocrine systems. In addition to chronic environmental exposure to arsenic, arsenic trioxide is approved for the clinical treatment of acute promyelocytic leukemia, and is in clinical trials for other hematological malignancies as well as solid tumors...
November 2016: Journal of Environmental Sciences (China)
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