Nathalie A J Verzele, Brendon Y Chua, Kirsty R Short, Aung Aung Kywe Moe, Isaac N Edwards, Helle Bielefeldt-Ohmann, Katina D Hulme, Ellesandra C Noye, Marcus Z W Tong, Patrick C Reading, Matthew W Trewella, Stuart B Mazzone, Alice E McGovern
Influenza A virus (IAV) is a common respiratory pathogen and a global cause of significant and often severe morbidity. Although inflammatory immune responses to IAV infections are well described, little is known about how neuroimmune processes contribute to IAV pathogenesis. In the present study, we employed surgical, genetic, and pharmacological approaches to manipulate pulmonary vagal sensory neuron innervation and activity in the lungs to explore potential crosstalk between pulmonary sensory neurons and immune processes...
April 16, 2024: PLoS Pathogens