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https://www.readbyqxmd.com/read/29031208/phytoecdysteroids-from-ajuga-iva-act-as-potential-antidiabetic-agent-against-alloxan-induced-diabetic-male-albino-rats
#1
Jin-Jun Wang, Hao Jin, Shao-Ling Zheng, Peng Xia, Yong Cai, Xiao-Jie Ni
The present study investigated the protective effect of phytoecdysteroids extracted from the Ajuga iva plant on body weight changes, blood glucose, insulin total protein, blood urea nitrogen (BUN), creatinine, triglycerides (TG), cholesterol, lipid peroxidation, antioxidant enzymes, pancreatic histopathology and hexokinase-I expression in the alloxan-induced diabetic rats. Experimental diabetes was induced following 15day intraperitoneal administration of alloxan. The rats were divided into four groups. Group I served as a sham group, and group II served as the diabetic control...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031176/a-case-of-dedifferentiated-liposarcoma-of-the-heart-and-stomach
#2
Yoichi Hisata, Yuichi Tasaki, Satoshi Kozaki, Takafumi Yamada
INTRODUCTION: Liposarcoma of the heart and stomach is rare. PRESENTAION OF CASE: We report a case of liposarcoma in both organs with dedifferentiated histology. A patient was referred to our hospital with anorexia and weight loss. Upper gastrointestinal tract endoscopy revealed 5-10-mm elevated lesions, and echocardiography and computed tomography showed tumorous lesions in the left atrium. Tumor resection and mitral valve replacement were performed, and biopsy was performed for the gastric tumor...
October 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29031117/reactions-of-melolontha-hippocastani-adults-to-high-manganese-content-in-food
#3
Petr Martinek, Emanuel Kula, Josef Hedbávný
Rapid adaptation of insect species to environmental changes can be advantageous for their development. Forest cockchafer (Melolontha hippocastani) is herbivorous insect species with high food intake that has been widely studied within European conditions. It can cause huge economic and ecological losses especially in oak-dominated forest stands. Food preference of this species is mainly comprised of trees with a potential to accumulate manganese in their assimilation apparatus. In order to determine cockchafer's reactions to increased Mn concentration in its food, the adults were reared in laboratory conditions controlled for temperature, humidity, and light on a natural diet of oak (Quercus petraea) leaves...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29029202/a-metabolomic-signature-of-acute-caloric-restriction
#4
Tinh-Hai Collet, Takuhiro Sonoyama, Elana Henning, Julia M Keogh, Brian Ingram, Sarah Kelway, Lining Guo, I Sadaf Farooqi
Context: The experimental paradigm of acute caloric restriction followed by refeeding can be used to study the homeostatic mechanisms that regulate energy homeostasis, which are relevant to understanding the adaptive response to weight loss. Objective: Metabolomics, the measurement of hundreds of small molecule metabolites, their precursors, derivatives, and degradation products, has emerged as a useful tool for the study of physiology and disease and was used here to study the metabolic response to acute caloric restriction...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028563/exploring-the-relationship-between-online-buyers-and-sellers-of-image-and-performance-enhancing-drugs-ipeds-quality-issues-trust-and-self-regulation
#5
Katinka van de Ven, Rosa Koenraadt
BACKGROUND: Online drug markets are expanding the boundaries of drug supply including the sale and purchase of image and performance enhancing drugs (IPEDs). However, the role of the internet in IPED markets, and in particular the ways in which these substances are supplied via the surface web, has rarely been considered. This article examines the online IPED market in order to inform drug policy and to provide a nuanced understanding of retailers involved, particularly exploring the relationship between buyers and sellers...
October 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29028547/-borneol-improves-the-efficacy-of-edaravone-against-dss-induced-colitis-by-promoting-m2-macrophages-polarization-via-jak2-stat3-signaling-pathway
#6
Xiong Zhang, Fang Xu, Li Liu, Lili Feng, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu
Compound edaravone injection (C.EDA), a compound preparation composed of edaravone (EDA) and (+)-Borneol with the mass ratio of 4: 1, displays a better anti-inflammatory activity than EDA. However, its precise mechanism remains to be further studied. In this work, we investigated whether (+)-Borneol could improve the efficacy of EDA against DSS-induced colitis. We found that C.EDA at 7.5 and 15mg/kg could significantly relieve the disease activity index (DAI) and reduce the loss of body weight and colon length in a dose-dependent manner, while EDA or (+)-Borneol alone only had moderate effects even at the highest dose...
October 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29028448/characterization-of-the-stool-microbiome-in-hispanic-preschool-children-by-weight-status-and-time
#7
Emily B Hollister, Byron A Foster, Mahmoud Dahdouli, Jesica Ramirez, Zhao Lai
BACKGROUND: Variations in gut microbiota composition and diversity have been associated with childhood adiposity, although most studies describing this have been cross-sectional in nature. Our objective was to evaluate associations between body weight and the gut microbiota over time in obese preschool-age children. METHODS: Obese, preschool-age, Hispanic children provided stool samples at baseline and following a 6-month behavioral intervention. Normal-weight (NW) children also provided stool samples...
October 13, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/29027993/current-pharmacotherapy-for-obesity
#8
REVIEW
Gitanjali Srivastava, Caroline M Apovian
More than one-third of adults in the USA have obesity, which causes, exacerbates or adversely impacts numerous medical comorbidities, including diabetes mellitus and cardiovascular disease. Despite intensive lifestyle modifications, the disease severity warrants further aggressive intervention, including pharmacotherapy, medical devices and bariatric surgery. Noninvasive anti-obesity drugs have thus now resurfaced as targeted adjunctive therapeutic approaches to intensive lifestyle intervention, bridging the gap between lifestyle and bariatric surgery...
October 13, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29027705/effects-of-dietary-supplementation-of-spices-on-forage-degradability-ruminal-fermentation-in-vivo-digestibility-growth-performance-and-nitrogen-balance-in-black-bengal-goat
#9
M R Chowdhury, M M H Khan, S U Mahfuz, M A Baset
The objective of the study was to evaluate the effects of spices on forage utilization and nitrogen (N) emission using in vitro and in vivo approach. A 6 × 5 factorial triplicate arrangement was used to assess the in vitro degradability of rice straw with control (without spices) and individual (40 mg/g rice straw) spices (cumin, coriander, clove, black cumin, turmeric) at five different incubation times. In vitro dry matter (DM) and organic matter (OM) degradability of rice straw were highest in presence of spices except for clove...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29027210/oedema-fibrosis-in-duchenne-muscular-dystrophy-role-of-cardiovascular-magnetic-resonance-imaging
#10
REVIEW
Sophie Mavrogeni, Antigoni Papavasiliou, Katerina Giannakopoulou, George Markousis-Mavrogenis, Maria Roser Pons, Evangelos Karanasios, Ioannis Nikas, George Papadopoulos, Genovefa Kolovou, George P Chrousos
Duchenne muscular dystrophy (DMD) is an X-linked muscle disorder characterized by progressive, irreversible loss of cardiac and skeletal muscular function. Muscular enlargement in DMD is attributed to oedema, due to the increased cytoplasmic Na+ concentration. The aim in this review is to present the current experience and emphasize the role of cardiovascular magnetic resonance (CMR) in the diagnosis of this condition. DMD patients' survival depends on ventilatory assistance, as respiratory muscle dysfunction was the most common cause of death in the past...
October 13, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29027206/low-grade-gastrointestinal-lymphoma-in-dogs-20-cases-2010-to-2016
#11
J Lane, J Price, A Moore, J R S Dandrieux, C Clifford, K Curran, K Choy, C Cannon
OBJECTIVES: To report the clinical presentation, treatment and prognosis of dogs with low-grade gastrointestinal lymphoma. MATERIALS AND METHODS: Cases were solicited from the American College of Veterinary Internal Medicine Oncology Diplomate listserv. Medical records of dogs with low-grade gastrointestinal lymphoma diagnosed via a combination of histology and immunohistochemistry with or without analysis of polymerase chain reaction for antigen receptor rearrangement were included...
October 13, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29026997/a-systematic-review-of-integrative-clinical-trials-for-supportive-care-in-pediatric-oncology-a-report-from-the-international-society-of-pediatric-oncology-t-cm-collaborative
#12
REVIEW
Andrea L Radossi, Katherine Taromina, Stacey Marjerrison, Caroline J Diorio, Raquel Similio, Festus Njuguna, Glenn M Afungchwi, Elena J Ladas
PURPOSE: Traditional and complementary medicine (T&CM) use in children with cancer is well established among high-income, upper middle-income, low-middle-income, and low-income countries (HIC, UMIC, LMIC, LIC, respectively). In HIC, a developing body of evidence exists for several T&CM therapies; however, evidence in other income settings is less well described despite a significantly higher use when compared to reports from HIC. The aim of this systematic review was to evaluate the evidence for T&CM for a variety of supportive care indications among children with cancer...
October 13, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29026760/etiological-and-clinicopathological-study-of-secondary-small-vessel-vasculitis-in-elderly-a-case-series-of-12-patients
#13
Ajay Kumar Mishra, Ramya Iyadurai, Anu Anna George, Ebenezer Rajdurai, V Surekha
BACKGROUND: Inflammation involving the postcapillary venular wall is defined as small vessel vasculitis. Small vessel vasculitis has various clinical manifestations. Etiologically, it can be primary or secondary. Literature regarding secondary vasculitis in elderly is scanty. AIM AND OBJECTIVES: In this case series, we aimed to assess the clinical features and etiologies of biopsy-proven secondary small vessel vasculitis in the elderly. METHODOLOGY: Twelve elderly patients with biopsy-proven small vessel vasculitis were included in this study...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026616/first-report-of-fatal-disseminated-microsporidiosis-in-two-inland-bearded-dragons-pogona-vitticeps-in-japan
#14
Kojiro Shibasaki, Toshihiro Tokiwa, Akihiro Sukegawa, Hirotaka Kondo, Kenichi Tamukai, Yumiko Haga, Kazunori Ike
Introduction.Encephalitozoon pogonae is a newly described pathogen belonging to the phylum Microsporidia. In Austria and the USA, this species has been isolated from fatal and disseminated cases of captive-bred inland bearded dragons. Here, we report the case of fatal disseminated microsporidiosis caused by E. pogonae in two bearded dragons in Japan. Case Presentation. The two lizards from different private households in Tokyo, Japan, had been brought to an animal hospital for examination. In both cases, the animal presented with a history of weight loss for several weeks...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026190/growth-hormone-secretagogues-hexarelin-and-jmv2894-protect-skeletal-muscle-from-mitochondrial-damages-in-a-rat-model-of-cisplatin-induced-cachexia
#15
Giuseppe Sirago, Elena Conte, Flavio Fracasso, Antonella Cormio, Jean-Alain Fehrentz, Jean Martinez, Clara Musicco, Giulia Maria Camerino, Adriano Fonzino, Laura Rizzi, Antonio Torsello, Angela Maria Serena Lezza, Antonella Liantonio, Palmiro Cantatore, Vito Pesce
Chemotherapy can cause cachexia, which consists of weight loss associated with muscle atrophy. The exact mechanisms underlying this skeletal muscle toxicity are largely unknown and co-therapies to attenuate chemotherapy-induced side effects are lacking. By using a rat model of cisplatin-induced cachexia, we here characterized the mitochondrial homeostasis in tibialis anterior cachectic muscle and evaluated the potential beneficial effects of the growth hormone secretagogues (GHS) hexarelin and JMV2894 in this setting...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025773/erdheim-chester-disease-atypical-presentation-of-a-rare-disease
#16
Cristian Ricardo Calandra, Ariel Bustos, Florencia Falcon, Naomi Arakaki
We report the clinical case of an adult patient referred to our hospital because of trismus due to a tumour in the right infratemporal and pterygomaxillary fossa. He referred hyporexia, weight loss and right trigeminal neuralgia. On physical examination, he had trismus and diplopia. On neuroimaging, the tumour invaded the central nervous system affecting the right temporal lobe and orbit, and the sellar region. Tumour biopsy revealed foamy histiocytes and isolated giant multinuclear cells immunoreactive to CD68 and negative to CD1a and S100...
October 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29025732/rack1-maintains-intestinal-homeostasis-by-protecting-the-integrity-of-the-epithelial-barrier
#17
Zhuan-Fen Cheng, Christine A Cartwright
Previously we generated mouse models of Rack1 deficiency to identify key functions for Rack1 in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia. However, other than low body weight, we did not detect an overt phenotype in mice constitutively deleted of Rack1 in intestinal epithelia (vil-Cre:Rack1(fl/fl) mice), presumably because Rack1 was deleted in < 10% of the total surface area of the epithelia...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29025694/desire-to-be-underweight-exploratory-study-on-a-weight-loss-app-community-and-user-perceptions-of-the-impact-on-disordered-eating-behaviors
#18
Elizabeth Victoria Eikey, Madhu C Reddy, Kayla M Booth, Lynette Kvasny, Johnna L Blair, Victor Li, Erika S Poole
BACKGROUND: Mobile health (mHealth) apps for weight loss (weight loss apps) can be useful diet and exercise tools for individuals in need of losing weight. Most studies view weight loss app users as these types of individuals, but not all users have the same needs. In fact, users with disordered eating behaviors who desire to be underweight are also utilizing weight loss apps; however, few studies give a sense of the prevalence of these users in weight loss app communities and their perceptions of weight loss apps in relation to disordered eating behaviors...
October 12, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29025677/degradation-of-glutamate-based-organogels-for-biodegradable-implants-in-vitro-study-and-in-vivo-observation
#19
Beibei Hu, Wenya Wang, Yumei Wang, Yang Yang, Lu Xu, Sanming Li
Degradation properties play a vital role in long-term in situ drug delivery systems. In vitro degradation behaviours of organogels were investigated via two approaches in this study: a weight loss method and a drug release method. Through the two methods, parameters that affect the degradation of organogels (such as gelator type, gelator concentration and oil type) were systematically tested under a lipase solution to better mimic in vivo circumstances. The gelator structure had the greatest influence on degradation behaviour...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025560/obesity-and-atrial-fibrillation-prevalence-pathogenesis-and-prognosis-effects-of-weight-loss-and-exercise
#20
REVIEW
Carl J Lavie, Ambarish Pandey, Dennis H Lau, Martin A Alpert, Prashanthan Sanders
Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remodeling in obese patients. However, numerous studies, including in AF, have demonstrated an obesity paradox, where overweight and obese patients with these disorders have a better prognosis than do leaner patients with the same degree of severity of cardiovascular disease/AF...
October 17, 2017: Journal of the American College of Cardiology
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