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https://www.readbyqxmd.com/read/29458121/the-paradox-of-marrow-adipose-tissue-in-anorexia-nervosa
#1
Pouneh K Fazeli, Anne Klibanski
Anorexia nervosa (AN) is a psychiatric disorder characterized by inappropriate nutrient intake resulting in low body weight. Multiple hormonal adaptations facilitate decreased energy expenditure in this state of caloric deprivation including non-thyroidal illness syndrome, growth hormone resistance, and hypogonadotropic hypogonadism. Although these hormonal adaptations confer a survival advantage during periods of negative energy balance, they contribute to the long-term medical complications associated with AN, the most common of which is significant bone loss and an increased risk of fracture...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29457842/long-term-outcomes-of-patients-undergoing-simultaneous-liver-transplantation-and-sleeve-gastrectomy
#2
Daniel Zamora-Valdes, Kymberly D Watt, Todd A Kellogg, John J Poterucha, Sara R Di Cecco, Nicki M Francisco-Ziller, Timucin Taner, Charles B Rosen, Julie K Heimbach
BACKGROUND: Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. AIM: To analyze the long term outcomes for obese patients undergoing LT including a non-invasive weight loss program and combined LT and sleeve gastrectomy (SG). METHODS: Since 2006, all patients referred for LT with a body mass index (BMI) ≥35 kg/m2 were enrolled. Patients who achieved weight loss (BMI<35) underwent LT alone, and those who did not underwent simultaneous LT+SG...
February 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29457416/-meta-analysis-of-the-efficacy-and-safety-of-pfna-and-intertan-for-the-treatment-of-intertrochanteric-fractures
#3
Jun-Jun Shi, Yu-Ze Wang, Yuan Li, Yuan-Peng Gao, Dong Wang, Zhi-Yong Wang, Zhi-Qiang Zhang
OBJECTIVE: To system evaluate the clinical effect and safety of PFNA and InterTAN internal fixation methods for femoral intertrochanteric fracture. METHODS: According to the Cochrane systemic analysis method, randomized controlled trials and quasi-randomized controlled trials which were about the comparison of PFNA and InterTAN for intertrochanteric fracture were collected from Cochrane Library(2017, issue 4), PubMed (January, 2003-May, 2017), Wanfang Med Online (January, 2003-May, 2017) and China Academic Journals Full-text Database(January, 2003-May, 2017) by computer searching...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29456979/quercetin-prevents-body-weight-loss-due-to-the-using-of-superparamagnetic-iron-oxide-nanoparticles-in-rat
#4
Rezvan Enteshari Najafabadi, Nasrin Kazemipour, Abolghasem Esmaeili, Siamak Beheshti, Saeed Nazifi
Background: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456899/facial-weakness-diplopia-and-fever-in-a-31-year-old-an-atypical-case-of-tuberculous-meningitis
#5
Ahmed H Qavi, Tasnim F Imran, Zachariah Hasan, Fariha Ilyas
Tuberculous meningitis (TBM) is an infection of the central nervous system (CNS) meninges that carries high morbidity and mortality. It is important to recognize, as patients may present with atypical symptoms. We describe the case of a 31-year-old man with a history of diabetes who presented with a sub-acute onset of right-sided facial weakness and right gaze difficulty with diplopia. History revealed low-grade fever, right-sided headache, fatigue and moderate weight loss for the past several weeks. The patient did not report neck stiffness, rigidity, fever, chills or cough...
December 7, 2017: Curēus
https://www.readbyqxmd.com/read/29456776/what-percentage-of-patients-is-a-candidate-for-unicompartmental-knee-replacement-at-a-chinese-arthroplasty-center
#6
Yong He, Lianbo Xiao, Weitao Zhai, Maximilian F Kasparek, Guilin Ouyang, Friedrich Boettner
Background: Data on indication of Unicompartmental Knee Arthroplasty (UKA) in the Asian population are currently not available. The current paper evaluates patients undergoing knee replacement at a Chinese Orthopaedic Specialty Hospital to report the percentage of patients who meet radiographic and clinical indication criteria for UKA. Methods: Over a one-year period 463 consecutive patients (515 knees) underwent primary knee replacement surgery. Clinical data were recorded and preoperative radiographs were assessed...
2018: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29456627/growth-and-lipid-accumulation-by-different-nutrients-in-the-microalga-chlamydomonas-reinhardtii
#7
Lei Yang, Jun Chen, Shan Qin, Min Zeng, Yongguang Jiang, Lang Hu, Peng Xiao, Wenlong Hao, Zhangli Hu, Anping Lei, Jiangxin Wang
Background: Individual nutrient depletion is widely used to induce lipid accumulation in microalgae, which also causes cell growth inhibition and decreases the total biomass. Thus, improving the lipid accumulation without biomass loss in the nutrient deficiency cells becomes a potential cost-effective treatment for cheaper biofuels. Methods: In this study, the effects of different nutritional conditions on the growth and contents of lipids in Chlamydomonas reinhardtii were compared, and the metabolic profiles under different nutritional conditions were also investigated...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29456533/non-hematopoietic-mlkl-protects-against-salmonella-mucosal-infection-by-enhancing-inflammasome-activation
#8
Shui-Xing Yu, Wei Chen, Zhen-Zhen Liu, Feng-Hua Zhou, Shi-Qing Yan, Gui-Qiu Hu, Xiao-Xia Qin, Jie Zhang, Ke Ma, Chong-Tao Du, Jing-Min Gu, Xu-Ming Deng, Wen-Yu Han, Yong-Jun Yang
The intestinal mucosal barrier is critical for host defense against pathogens infection. Here, we demonstrate that the mixed lineage kinase-like protein (MLKL), a necroptosis effector, promotes intestinal epithelial barrier function by enhancing inflammasome activation. MLKL-/- mice were more susceptible to Salmonella infection compared with wild-type counterparts, with higher mortality rates, increased body weight loss, exacerbated intestinal inflammation, more bacterial colonization, and severe epithelial barrier disruption...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456420/timely-news-for-the-multidisciplinary-care-team
#9
Max Bingham
Welcome to Diabetes Spectrum 's first installment of Diabetes is Primary, a round-up of the latest diabetes developments for health care providers. In this issue, we take a look at radical weight loss for diabetes remission, Hong Kong's diabetes risk assessment and management program, personalized A1C targets, and diabetes diagnoses. The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) panel gives its verdict on continuous glucose monitoring (CGM) devices, and we learn how Medicare will soon pay for a diabetes prevention program...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29455993/polysaccharide-from-ostrea-rivularis-attenuates-reproductive-oxidative-stress-damage-via-activating-keap1-nrf2-are-pathway
#10
Shijie Li, Zhuoyue Song, Tingting Liu, Jian Liang, Jun Yuan, Zhanchi Xu, Zhanghua Sun, Xiaoping Lai, Qingping Xiong, Danyan Zhang
The purpose of this study was to investigate the effects of Ostrea rivularis polysaccharide (ORP) against testicular oxidative stress injury via kelch-like ECH-associated protein 1-nuclear erythroid 2-related factor 2/antioxidant response element (Keap1-Nrf2/ARE) pathway. In pharmacological experiments in vivo, ORP administration could dose-dependently inhibit body and testicular weight loss, ameliorate epididymal sperm quality and protect reproductive impairment in cyclophosphamide-induced male Balb/c mice...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455756/a-randomized-trial-of-weight-change-in-a-national-home-visiting-program
#11
Debra Haire-Joshu, Cynthia D Schwarz, Karen Steger-May, Christy Lapka, Kenneth Schechtman, Ross C Brownson, Rachel G Tabak
INTRODUCTION: Clinical trials have demonstrated significant impact in reducing weight and incidence of type 2 diabetes mellitus. However, the intensity of these trials limits their scalability to real world settings. The purpose of this study was to embed a lifestyle intervention for overweight and obese mothers within the routine practice of a parent education, home visiting organization. DESIGN: Pragmatic trial that used a stratified random design. SETTING/PARTICIPANTS: Overweight or obese mothers of preschool children located across St...
March 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29455721/fit4yams-structuring-a-lifestyle-intervention-for-rural-overweight-and-obese-young-adult-males-using-participatory-design
#12
Jannine Bailey, Cristyn Davies, Timothy McCrossin, Michael Kiernan, Rachel Skinner, Katharine Steinbeck, Kumara Mendis
PURPOSE: Young adult males (YAMs) are understudied with respect to lifestyle interventions to address overweight and obesity in this group. This study reports on the participatory design of the structure and delivery of the Fit4YAMs text message-based lifestyle intervention for 18- to 25-year-old rural YAMs in Australia. METHODS: Two semi-structured focus group discussions were held with six overweight or obese YAMs. Sessions explored their preferences for the structure and delivery of a weight loss intervention...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29455406/conversional-weight-loss-surgery-an-australian-experience-of-converting-laparoscopic-adjustable-gastric-bands-to-laparoscopic-sleeve-gastrectomy
#13
M Devadas, D J Ku
BACKGROUND: Bariatric surgery is the most effective treatment for severe obesity, capable of producing more than 50% excess weight loss at 10-year follow-up (James Clin Dermatol 1; 22:276-80; O'Brien Br J Surg 2; 102:611-17; Buchwald et al. Metab Syndr 3; 347-56). The success of bariatric surgery extends far beyond weight loss, with up to 80-90% of patients having improvement or resolution of many of their weight-related co-morbidities including type II diabetes mellitus and hypertension (Puzziferri et al...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29455404/the-effect-of-pre-surgery-information-online-lecture-on-nutrition-knowledge-and-anxiety-among-bariatric-surgery-candidates
#14
Shiri Sherf-Dagan, Keren Hod, Limor Mardy-Tilbor, Shir Gliksman, Tair Ben-Porat, Nasser Sakran, Shira Zelber-Sagi, David Goitein, Asnat Raziel
INTRODUCTION: Best practices for patient education in bariatric surgery (BS) remain undefined. The aims of this study were to evaluate the effect of an online lecture on nutrition knowledge, weight loss expectations, and anxiety among BS candidates and present a new tool to assess this knowledge before BS. METHODS: An interventional non-randomized controlled trial on 200 BS candidates recruited while attending a pre-BS committee. The first 100 consecutive patients were assigned to the control group and the latter 100 consecutive patients to the intervention group and were instructed to watch an online lecture of 15-min 1-2 weeks prior to surgery...
February 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29455119/developing-a-safety-heatmap-of-uncontrolled-intersections-using-both-conflict-probability-and-severity
#15
Yingying Ma, Xiaoran Qin, Offer Grembek, Zhiwei Chen
This paper presents a method to assess the safety of uncontrolled intersections considering two major properties of traffic conflicts-conflict probability and severity. This method assesses both the safety level of the entire intersection in addition to the distribution of safety within it. Intersections are modeled by a two-dimensional Cartesian coordinate system and the internal space of intersections is divided into cells. First, the vehicle movement characteristics of an uncontrolled intersection are modeled...
February 15, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29454882/1-5-dimethylhexylamine-octodrine-in-sports-and-weight-loss-supplements-natural-constituent-or-synthetic-chemical
#16
Mei Wang, Saqlain Haider, Amar G Chittiboyina, Jon F Parcher, Ikhlas A Khan
In the past years, there has been a mounting trend toward the addition of sympathomimetic stimulants in sports and weight loss supplements sold in the US and claimed to be from natural constituents. The latest among those pharmaceutical stimulants is 1,5-dimethylhexylamine (1,5-DMHA or octodrine), an ingredient in newly introduced sports and weight loss supplements with its 'natural' origin being cited from Aconitum or Kigelia plants. In order to validate the natural existence of 1,5-DMHA, two GC/MS methods were developed...
February 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29454535/insurance-mandated-preoperative-diet-and-outcomes-after-bariatric-surgery
#17
Charles J Keith, Lauren E Goss, Camille D Blackledge, Richard D Stahl, Jayleen Grams
BACKGROUND: Despite a lack of demonstrated patient benefit, many insurance providers mandate a physician-supervised diet before financial coverage for bariatric surgery. OBJECTIVES: To compare weight loss between patients with versus without insurance mandating a preoperative diet. SETTING: University hospital, United States. METHODS: Retrospective study of all patients who underwent laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy over a 5-year period, stratified based on whether an insurance-mandated physician-supervised diet was required...
February 2, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29454467/microvascular-decompression-for-hemifacial-spasm-outcome-on-spasm-and-complications-a-review
#18
M Sindou, P Mercier
Over the last decades microvascular decompression (MVD) has been established as the curative treatment of the primary Hemifacial Spasm (HFS), proven to be linked in almost all cases to a neurovascular compression of the facial nerve. Because the disease is not life-threatening and MVD not totally innocuous, efficacy and safety have to be weighted before decision taken of indicating surgery. The authors have been charged by the French Speaking Society of Neurosurgery to conduct a detailed evaluation of the probability of relief of the spasm that MVD is able to obtain, together with its potential complications...
February 14, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29454318/points-based-physical-activity-a-novel-approach-to-facilitate-changes-in-body-composition-in-inactive-women-with-overweight-and-obesity
#19
Adrian Holliday, Alice Burgin, Elyzabeth Vargas Fernandez, Sally A M Fenton, Frank Thielecke, Andrew K Blannin
BACKGROUND: Physical activity (PA) interventions for the promotion of weight-management may benefit from increased choice and flexibility to overcome commonly-perceived barriers to PA. The aim of this study was to investigate the effects of a novel "points-based" approach to PA on body composition in inactive women, who are overweight or obese. METHODS: Seventy-six overweight or obese, inactive women were randomly allocated to one of three conditions: 'Points-based' PA (PBPA; 30 "PA points"•week- 1 ), Structured exercise (StructEx; 150 min moderate-intensity exercise•week- 1 ) or control (CONT; continue habitual inactive lifestyle) for a 24-week intervention...
February 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29454140/weight-management-in-rural-health-clinics-the-midwest-diet-and-exercise-trial
#20
Anna M Gorczyca, Richard A Washburn, Lauren Ptomey, Matthew S Mayo, Debra K Sullivan, Cheryl A Gibson, Robert Lee, Sarah Stolte, Joseph E Donnelly
Obesity prevalence is higher in rural compared to urban residents. Rural health clinics offer a potential venue for delivery of weight management. However, traditional programs require travel to attend on-site meetings which is impractical or inconvenient for rural residents. Clinic staff in most rural settings are unlikely to be trained to provide effective weight management. Remote delivery using group phone conferences (GP) or individual phone calls (IP), by staff associated with rural clinics eliminates the need for travel to attend on-site meetings...
February 14, 2018: Contemporary Clinical Trials
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