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Naoki Iwamoto, Atsushi Kawakami
Abatacept (ABT) is a recombinant fusion protein comprising the extracellular domain of human CTLA4, which inhibits the activation of T cells. Several clinical trials have provided evidence of efficacy and safety of ABT in the patients with rheumatoid athritis (RA) with various clinical characteristics such as MTX inadequate responders (IR), TNF inhibitor-IR. Moreover, indirect comparison of ABT to other biologics reported in Cochrane review revealed that ABT has better safety profile in serious adverse events and serious infection Thus the features of ABT in the treatment of RA have gradually become apparent and knowledge of these features is helpful for better use of biologics...
June 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
Camila Pugliese, Roberta T A van der Vinne, Lucia M A Campos, Priscila R Guardieiro, Cynthia Saviolli, Eloisa Bonfá, Rosa M R Pereira, Vilma S Viana, Eduardo F Borba, Clovis A Silva
The impact of juvenile idiopathic arthritis (JIA) in periodontal diseases is controversial probably due to gender and age heterogeneity. We therefore evaluated a homogeneous female post-pubertal JIA population for these conditions. Thirty-five JIA patients and 35 gender/age comparable healthy controls were evaluated according to demographic data, complete periodontal evaluation, fasting lipoproteins, and anti-lipoprotein lipase antibodies. JIA scores, laboratorial tests, X-rays, and treatment were also assessed...
January 2016: Clinical Rheumatology
Zachary A Marcum, Hanzi Lena Zhan, Subashan Perera, Charity G Moore, G Kelley Fitzgerald, Debra K Weiner
OBJECTIVE: This study aims to evaluate correlates of gait speed, a measure of disability, in older adults with advanced knee osteoarthritis (OA) and chronic pain. DESIGN/SETTING/SUBJECTS/METHODS: Baseline data were analyzed from a clinical trial of 190 participants aged >50 with advanced knee OA (according to clinical and radiographic American College of Rheumatology criteria) and chronic pain. Data included 4-meter gait speed, quality of life (Short Form Health Survey 36 global health subscale), knee pain (Western Ontario and McMasters Universities Osteoarthritis Index [WOMAC]), depressive symptoms (Center for Epidemiologic Studies Depression Scale), coping strategies (catastrophizing subscale and Cognitive Strategies Questionnaire), self-efficacy (Athritis Self-efficacy Scale [ASES]), comorbidity (Cumulative Illness Rating Scale), analgesic use, and pain comorbidities (location, frequency, and intensity)...
August 2014: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Anna Chludzińska, Lech Chrostek, Bogdan Cylwik
The alterations in glycosylation of serum glycoproteins were reported in several pathological conditions including rheumatic diseases. The many studies demonstrated the occurrence of some differentially glycosylated plasma immunoglobulins, especially IgG in rheumatoid arthritis. The most characteristic features are the decrease in galactose content, the presence of N-acetylglucosamine and the increase in fucose content. The structure of oligosaccharides attached to the antibody Fc region affect the pharmacokinetics and antibody effector functions of antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity...
August 2012: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Hajime Yamanaka, Ken-ichiro Goto, Munetaka Suzuki
BACKGROUND: Total knee arthroplasty (TKA) is a common form of treatment to relieve pain and improve function in cases of rheumatoid arthritis (RA). Good clinical outcomes have been reported with a variety of TKA prostheses. The cementless Hi-Tech Knee II cruciate-retaining (CR)-type prosthesis, which has 6 fins at the anterior of the femoral component, posterior cruciate ligament (PCL) retention, flat-on-flat surface component geometry, all-polyethylene patella, strong initial fixation by the center screw of the tibial base plate, 10 layers of titanium alloy fiber mesh, and direct compression molded ultra high molecular weight polyethylene (UHMWPE), is appropriate for TKA in the Japanese knee...
2012: Journal of Orthopaedic Surgery and Research
Andreas Hensel, Mareike Maas, Jandirk Sendker, Matthias Lechtenberg, Frank Petereit, Alexandra Deters, Thomas Schmidt, Timo Stark
ETHNOPHARMACOLOGICAL RELEVANCE: Eupatorium perfoliatum L. originates from North America, where it has been widely used since centuries by native Indians. Additionally extracts are used also in Europe as immunostimulating agent for treatment of fever and cold. The following review summarizes published data on phytochemistry, ethnopharmacological use, as well as clinical and preclinical data. MATERIALS AND METHODS: Literature survey was performed via SciFinder(®) on papers and patents and by systematic research in ethnopharmacological literature at various university libraries...
December 8, 2011: Journal of Ethnopharmacology
Consuelo Modesto
CINCA/NOMID syndrome was first reported in 1981, identified as a new disease in 1987 and the main cause discovered in 2001, when mutations in the CIAS1 gene modifying the structure of the protein cryopirin were found in those patients (although other factors seem to play a role). Together with the major symptoms that characterized the syndrome, neurological, cutaneous and articular manifestations, others have been added which seem to be quite constant among CINCA/NOMID diagnosed patients: pre and perinatal symptoms, morfological changes, outbreaks of fever and biological abnormalities which reveal a persistent inflammatory background...
January 2011: Medicina Clínica
P Nigam, D Singh, V S Matreja, H N Saxena
A less documented entity of psoriatic arthritis was studied in 238 cases of psoriasis and it was detected in 5.1 % of cases. The prevalence of arthritis was found in the population over 40 years of age and was 2.7% of the males and 8.2% of the females. Psoriatic arthritis was much more common in females (male to female ratio = 1:2) in contrast to male predominance in psoriasis (male to female ratio = 1.6:1. Skin lesions usually precede the arthritis (50%); in others the onset is synchronous (41.7%) and in few of them the arthritis may come first (8...
February 1980: Journal of Dermatology
M Q Hassan, R A Hadi, Z S Al-Rawi, V A Padron, S J Stohs
In order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (RA), serum reduced glutathione levels (GSH), glutathione reductase (GSR), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and alkaline phosphatase (ALP) activities, lipid peroxidation (MDA content) and indexes of inflammation were evaluated in 58 rheumatic patients. Rheumatoid athritis was associated with significant depletion (ca. 50%) in GSH levels compared with normal control subjects...
January 2001: Journal of Applied Toxicology: JAT
S M Anderton, R van der Zee, B Prakken, A Noordzij, W van Eden
Lewis rats are susceptible to several forms of experimental arthritis-induced using heat-killed Mycobacterium tuberculosis (adjuvant arthritis, or AA), streptococcal cell walls, collagen type II, and the lipoidal amine CP20961. Prior immunization with the mycobacterial 65-kD heat shock protein (hsp65) was reported to protect against AA, and other athritis models not using M. tuberculosis, via a T cell-mediated mechanism. Hsp65 shares 48% amino acid identity with mammalian hsp60, which is expressed at elevated levels in inflamed synovia...
March 1, 1995: Journal of Experimental Medicine
R D Simon, L E Ford
A 76-year-old woman with rapidly progressive athritis associated with a rising rheumatoid factor, acute joint effusion, and fever had remission of her symptoms and return of her laboratory values to normal following removal of a colonic carcinoma.
May 1980: Archives of Internal Medicine
Z Stazka
No abstract text is available yet for this article.
June 7, 1971: Polski Tygodnik Lekarski
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