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https://www.readbyqxmd.com/read/27890939/the-metal-face-of-protein-tyrosine-phosphatase-1b
#1
REVIEW
Elisa Bellomo, Kshetrimayum Birla Singh, Alberto Massarotti, Christer Hogstrand, Wolfgang Maret
A new paradigm in metallobiochemistry describes the activation of inactive metalloenzymes by metal ion removal. Protein tyrosine phosphatases (PTPs) do not seem to require a metal ion for enzymatic activity. However, both metal cations and metal anions modulate their enzymatic activity. One binding site is the phosphate binding site at the catalytic cysteine residue. Oxyanions with structural similarity to phosphate, such as vanadate, inhibit the enzyme with nanomolar to micromolar affinities. In addition, zinc ions (Zn(2+)) inhibit with picomolar to nanomolar affinities...
November 15, 2016: Coordination Chemistry Reviews
https://www.readbyqxmd.com/read/27890727/synthetic-tambjamine-analogues-induce-mitochondrial-swelling-and-lysosomal-dysfunction-leading-to-autophagy-blockade-and-necrotic-cell-death-in-lung-cancer
#2
Ananda M Rodilla, Luís Korrodi-Gregório, Elsa Hernando, Pilar Manuel-Manresa, Roberto Quesada, Ricardo Pérez-Tomás, Vanessa Soto-Cerrato
Current pharmacological treatments for lung cancer show very poor clinical outcomes, therefore, the development of novel anticancer agents with innovative mechanisms of action is urgently needed. Cancer cells have a reversed pH gradient compared to normal cells, which favours cancer progression by promoting proliferation, metabolic adaptation and evasion of apoptosis. In this regard, the use of ionophores to modulate intracellular pH appears as a promising new therapeutic strategy. Indeed, there is a growing body of evidence supporting ionophores as novel antitumour drugs...
November 24, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27882891/a-comparative-mass-spectrometric-study-of-fatty-acids-and-metals-in-some-seed-extracts
#3
Sonia Niculina Suvar, R Bleiziffer, P Podea, A Iordache, C Voica, R Zgavarogea, M Culea
A major cause of cardiovascular diseases and cancer is diet content, so the optimization of micronutrients in food is very important. Omega-3 fatty acids supplementation for patients had beneficial effects on subjective global assessment score and metabolic profiles. Fatty acids content and the metal ions in different seeds (e.g. linseed, poppy, grape, hemp, nuts, pumpkin, sesame, watermelon, chia) recommended as food supplements, purchased on the Romanian market, were compared. Gas chromatography coupled to mass spectrometry (GC-MS) was used as an excellent technique for fatty acids identification and quantitation, and inductively coupled plasma mass spectrometer (ICP-MS) for analytical measurements of metals...
2016: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/27856537/phosphocysteine-in-the-prl-cnnm-pathway-mediates-magnesium-homeostasis
#4
Irina Gulerez, Yosuke Funato, Howie Wu, Meng Yang, Guennadi Kozlov, Hiroaki Miki, Kalle Gehring
PRLs (phosphatases of regenerating liver) are frequently overexpressed in human cancers and are prognostic markers of poor survival. Despite their potential as therapeutic targets, their mechanism of action is not understood in part due to their weak enzymatic activity. Previous studies revealed that PRLs interact with CNNM ion transporters and prevent CNNM4-dependent Mg(2+) transport, which is important for energy metabolism and tumor progression. Here, we report that PRL-CNNM complex formation is regulated by the formation of phosphocysteine...
December 2016: EMBO Reports
https://www.readbyqxmd.com/read/27804847/the-warburg-effect-and-the-hallmarks-of-cancer
#5
Laurent Schwartz, Claudiu T Supuran, Khalid O Alfarouk
It is a longstanding debate whether cancer is one disease or a set of very diverse diseases. The goal of this paper is to suggest strongly that most (if not all) the hallmarks of cancer could be the consequence of the Warburg's effect. As a result of the metabolic impairment of the oxidative phosphorylation, there is a decrease in ATP concentration. To compensate the reduced energy yield, there is massive glucose uptake, anaerobic glycolysis, with an up-regulation of the Pentose Phosphate Pathway resulting in increased biosynthesis leading to increased cell division and local pressure...
October 31, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27783898/lipid-heterogeneity-resulting-from-fatty-acid-processing-in-the-human-breast-cancer-microenvironment-identified-by-gcib-tof-sims-imaging
#6
Tina Bernadette Angerer, Ylva Magnusson, Goran Landberg, John Stephen Fletcher
Breast cancer is an umbrella term used to describe a collection of different diseases with broad inter- and intra-tumor heterogeneity. Understanding this variation is critical in order to develop, and precisely prescribe, new treatments. Changes in the lipid metabolism of cancerous cells can provide important indications as to the metabolic state of the cells but are difficult to investigate with conventional histological methods. Due to the introduction of new higher energy (40 kV) gas cluster ion beams (GCIBs) time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging is now capable of providing information on the distribution of hundreds of molecular species simultaneously on a cellular to sub-cellular scale...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27765658/occupational-exposures-at-a-polyvinyl-chloride-production-facility-are-associated-with-significant-changes-to-the-plasma-metabolome
#7
John J Guardiola, Juliane I Beier, K Cameron Falkner, Benjamin Wheeler, Craig James McClain, Matt Cave
BACKGROUND: Occupational vinyl chloride (VC) exposures have been associated with toxicant-associated steatohepatitis and liver cancer. Metabolomics has been used to clarify mode of action in drug-induced liver injury but has not been performed following VC exposures. METHODS: Plasma samples from 17 highly exposed VC workers without liver cancer and 27 unexposed healthy volunteers were obtained for metabolite extraction and GC/MS and LC/MS(2) analysis. Following ion identification/quantification, Ingenuity pathway analysis was performed...
December 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27752286/low-mass-ion-discriminant-equation-lome-for-ovarian-cancer-screening
#8
Jun Hwa Lee, Byong Chul Yoo, Yun Hwan Kim, Sun-A Ahn, Seung-Gu Yeo, Jae Youl Cho, Kyung-Hee Kim, Seung Cheol Kim
BACKGROUND: A low-mass-ion discriminant equation (LOME) was constructed to investigate whether systematic low-mass-ion (LMI) profiling could be applied to ovarian cancer (OVC) screening. RESULTS: Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry was performed to obtain mass spectral data on metabolites detected as LMIs up to a mass-to-charge ratio (m/z) of 2500 for 1184 serum samples collected from healthy individuals and patients with OVC, other types of cancer, or several types of benign tumor...
2016: BioData Mining
https://www.readbyqxmd.com/read/27748798/metabolomic-profiling-of-breast-tumors-using-ductal-fluid
#9
Luisa Matos Do Canto, Catalin Marian, Rency S Varghese, Jaeil Ahn, Patricia A Da Cunha, Shawna Willey, Mary Sidawy, Janice D Rone, Amrita K Cheema, George Luta, Mohammad R Nezami Ranjbar, Habtom W Ressom, Bassem R Haddad
Identification of new biomarkers for breast cancer remains critical in order to enhance early detection of the disease and improve its prognosis. Towards this end, we performed an untargeted metabolomic analysis of breast ductal fluid using an ultra-performance liquid chromatography coupled with a quadrupole time-of-light (UPLC-QTOF) mass spectrometer. We investigated the metabolomic profiles of breast tumors using ductal fluid samples collected by ductal lavage (DL). We studied fluid from both the affected breasts and the unaffected contralateral breasts (as controls) from 43 women with confirmed unilateral breast cancer...
October 13, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27738498/in-vivo-evaluation-of-riboflavin-receptor-targeted-fluorescent-uspio-in-mice-with-prostate-cancer-xenografts
#10
Jabadurai Jayapaul, Susanne Arns, Matt Bunker, Marek Weiler, Sandra Rutherford, Peter Comba, Fabian Kiessling
: Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (e.g. flavin mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparamagnetic iron oxide (FLUSPIO) nanoparticles are suitable for labeling metabolically active cancer and endothelial cells in vitro. In this study, we focused on the in vivo application of FLUSPIO using prostate cancer xenografts. Size, charge, and chemical composition of FLUSPIO were evaluated...
2016: Nano Research
https://www.readbyqxmd.com/read/27703266/lc-ms-based-sphingolipidomic-study-on-a2780-human-ovarian-cancer-cell-line-and-its-taxol-resistant-strain
#11
Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang, Zhi-Hong Jiang
Drug resistance elicited by cancer cells continue to cause huge problems world-wide, for example, tens of thousands of patients are suffering from taxol-resistant human ovarian cancer. However, its biochemical mechanisms remain unclear. Sphingolipid metabolic dysregulation has been increasingly regarded as one of the drug-resistant mechanisms for various cancers, which in turn provides potential targets for overcoming the resistance. In the current study, a well-established LC-MS based sphingolipidomic approach was applied to investigate the sphingolipid metabolism of A2780 and taxol-resistant A2780 (A2780T) human ovarian cancer cell lines...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27696867/the-fecal-metabolome-in-hmga1-transgenic-mice-with-polyposis-evidence-for-potential-screen-for-early-detection-of-precursor-lesions-in-colorectal-cancer
#12
Michael David Williams, Lingling Xian, Tait Huso, Jeong-Jin Park, David Huso, Leslie M Cope, David R Gang, William F Siems, Linda Resar, Raymond Reeves, Herbert H Hill
Because colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, more accessible screening tests are urgently needed to identify early-stage lesions. We hypothesized that highly sensitive, metabolic profile analysis of stool samples will identify metabolites associated with early-stage lesions and could serve as a noninvasive screening test. We therefore applied travelling wave ion mobility mass spectrometry (TWIMMS) coupled with ultra-performance liquid chromatography (UPLC) to investigate metabolic aberrations in stool samples in a transgenic model of pre-malignant polyposis aberrantly expressing the gene encoding the high mobility group A (Hmga1) chromatin remodeling protein...
October 4, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27662498/nano-cesium-for-anti-cancer-properties-an-investigation-into-cesium-induced-metabolic-interference
#13
Enrique A Daza, Santosh K Misra, Aaron S Schwartz-Duval, Ayako Ohoka, Callie Miller, Dipanjan Pan
The use of cesium chloride (CsCl) for cancer therapy ("high pH therapy") has been theorized to produce anticancer properties by raising intracellular pH to induce apoptosis. Although considered as "alternative medicine", little scientific evidence supports this theory. Alternatively, cells have no cesium ion (Cs(+)) mediated channels for clearance. Thus, such unstable electrochemical distributions have the severe potential to disrupt electrochemical dependent cellular processes, such as glucose cotransporters...
October 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27659785/quantitative-proteome-analysis-of-colorectal-cancer-related-differential-proteins
#14
Yanbin Zhang, Yue Liu, Yingjiang Ye, Danhua Shen, Hui Zhang, Hongyan Huang, Sha Li, Shan Wang, Jun Ren
PURPOSE: To evaluate a new strategy for profiling proteomic changes in colorectal cancer (CRC). METHODES: We used laser capture microdissection (LCM) to obtain cells from 20 CRC and paired normal mucosal tissues. The differential proteins between the microdissected tumor cells and normal mucosa epithelia were analyzed by acetylation stable isotopic labeling coupled with L linear ion trap Fourier transform ion cyclotron resonance mass spectrometry (LTQ-FT MS). Western blotting was used to assess the differential expression of proteins...
September 22, 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27633879/copper-ii-ions-affect-the-gating-dynamics-of-the-20s-proteasome-a-molecular-and-in-cell-study
#15
Anna Maria Santoro, Irene Monaco, Francesco Attanasio, Valeria Lanza, Giuseppe Pappalardo, Marianna Flora Tomasello, Alessandra Cunsolo, Enrico Rizzarelli, Ada De Luigi, Mario Salmona, Danilo Milardi
Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes endowed with proteasome inhibition features has emerged as a promising anticancer strategy. However, limited information is available about the exact mechanism by which copper inhibits proteasome. Here we show that Cu(II) ions simultaneously inhibit the three peptidase activities of isolated 20S proteasomes with potencies (IC50) in the micromolar range...
September 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27625993/news-about-vdac1-in-hypoxia
#16
N M Mazure
The voltage-dependent anion channel (VDAC) is the main interface between the cytosol and mitochondria of cells. It plays a crucial role in both mitochondrial metabolism and cell death. The main basic function of this channel is to mediate and gate the flux of small ions, metabolites, and adenosine triphosphate. Changes in its structure, and thus conformation, are expected to affect its activity and modulate the ability of cancer cells to expand. In this review, we describe a novel mechanism by which mitochondria of cells in hypoxia, a low level of oxygen, protects from apoptosis...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27570558/targeting-negative-surface-charges-of-cancer-cells-by-multifunctional-nanoprobes
#17
Bingdi Chen, Wenjun Le, Yilong Wang, Zhuoquan Li, Dong Wang, Lei Ren, Ling Lin, Shaobin Cui, Jennifer J Hu, Yihui Hu, Pengyuan Yang, Rodney C Ewing, Donglu Shi, Zheng Cui
A set of electrostatically charged, fluorescent, and superparamagnetic nanoprobes was developed for targeting cancer cells without using any molecular biomarkers. The surface electrostatic properties of the established cancer cell lines and primary normal cells were characterized by using these nanoprobes with various electrostatic signs and amplitudes. All twenty two randomly selected cancer cell lines of different organs, but not normal control cells, bound specifically to the positively charged nanoprobes...
2016: Theranostics
https://www.readbyqxmd.com/read/27560777/smartphone-analytics-mobilizing-the-lab-into-the-cloud-for-omic-scale-analyses
#18
J Rafael Montenegro-Burke, Thiery Phommavongsay, Aries E Aisporna, Tao Huan, Duane Rinehart, Erica Forsberg, Farris L Poole, Michael P Thorgersen, Michael W W Adams, Gregory Krantz, Matthew W Fields, Trent R Northen, Paul D Robbins, Laura J Niedernhofer, Luke Lairson, H Paul Benton, Gary Siuzdak
Active data screening is an integral part of many scientific activities, and mobile technologies have greatly facilitated this process by minimizing the reliance on large hardware instrumentation. In order to meet with the increasingly growing field of metabolomics and heavy workload of data processing, we designed the first remote metabolomic data screening platform for mobile devices. Two mobile applications (apps), XCMS Mobile and METLIN Mobile, facilitate access to XCMS and METLIN, which are the most important components in the computer-based XCMS Online platforms...
October 4, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27551682/distinctly-perturbed-metabolic-networks-underlie-differential-tumor-tissue-damages-induced-by-immune-modulator-%C3%AE-glucan-in-a-two-case-ex-vivo-non-small-cell-lung-cancer-study
#19
Teresa W-M Fan, Marc O Warmoes, Qiushi Sun, Huan Song, Jadwiga Turchan-Cholewo, Jeremiah T Martin, Angela Mahan, Richard M Higashi, Andrew N Lane
Cancer and stromal cell metabolism is important for understanding tumor development, which highly depends on the tumor microenvironment (TME). Cell or animal models cannot recapitulate the human TME. We have developed an ex vivo paired cancerous (CA) and noncancerous (NC) human lung tissue approach to explore cancer and stromal cell metabolism in the native human TME. This approach enabled full control of experimental parameters and acquisition of individual patient's target tissue response to therapeutic agents while eliminating interferences from genetic and physiological variations...
July 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27544999/immune-response-associated-gene-analysis-of-1-000-cancer-patients-using-whole-exome-sequencing-and-gene-expression-profiling-project-hope
#20
Yasuto Akiyama, Ryota Kondou, Akira Iizuka, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Yuji Shimoda, Tomoe Tanabe, Sumiko Ohnami, Shumpei Ohnami, Masatoshi Kusuhara, Tohru Mochizuki, Ken Yamaguchi
Project HOPE (High-tech Omics-based Patient Evaluation) has been progressing since its implementation in 2014 using whole-exome sequencing (WES) and gene expression profiling (GEP). With the aim of evaluating immune status in cancer patients, a gene panel consisting of 164 immune response-associated genes (56 antigen-presenting cell and T-cell-associated genes, 34 cytokine- and metabolism-associated genes, 47 TNF and TNF receptor superfamily genes, and 27 regulatory T-cell-associated genes) was established, and its expression and mutation status were investigated using 1,000 cancer patient-derived tumors...
2016: Biomedical Research
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