keyword
https://read.qxmd.com/read/38493498/yy1-lactylation-aggravates-autoimmune-uveitis-by-enhancing-microglial-functions-via-inflammatory-genes
#1
JOURNAL ARTICLE
Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Hou
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin-Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune-mediated diseases. Here, an increased YY1 lactylation in retinal microglia within in the experimental autoimmune uveitis (EAU) group is observed. YY1 lactylation contributed to boosting microglial activation and promoting their proliferation and migration abilities. Inhibition of lactylation suppressed microglial activation and attenuated inflammation in EAU...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38493378/designing-an-implementable-clinical-prediction-model-for-near-term-mortality-and-long-term-survival-in-patients-on-maintenance-hemodialysis
#2
JOURNAL ARTICLE
Benjamin A Goldstein, Chun Xu, Jonathan Wilson, Ricardo Henao, Patti L Ephraim, Daniel E Weiner, Tariq Shafi, Julia J Scialla
RATIONALE & OBJECTIVE: The life expectancy of patients treated with maintenance hemodialysis (MHD) is heterogeneous. Knowledge of life-expectancy may focus care decisions on near-term versus long-term goals. The current tools are limited and focus on near-term mortality. Here, we develop and assess potential utility for predicting near-term mortality and long-term survival on MHD. STUDY DESIGN: Predictive modeling study. SETTING & PARTICIPANTS: 42,351 patients contributing 997,381 patient months over 11 years, abstracted from the electronic health record (EHR) system of midsize, nonprofit dialysis providers...
February 21, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38493366/cross-validation-of-the-response-bias-scale-and-the-response-bias-scale-19-in-active-duty-personnel-use-on-the-mmpi-2-rf-and-mmpi-3
#3
JOURNAL ARTICLE
Paul B Ingram, Patrick Armistead-Jehle, Lucas G Childers, Tristan T Herring
The Response Bias Scale (RBS) is the central measure of cognitive over-reporting in the MMPI-family of instruments. Relative to other clinical populations, the research evaluating the detection of over-reporting is more limited in Veteran and Active-Duty personnel, which has produced some psychometric variability across studies. Some have suggested that the original scale construction methods resulted in items which negatively impact classification accuracy and in response crafted an abbreviated version of the RBS (RBS-19; Ratcliffe et al...
March 17, 2024: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38493298/partial-trailside-japanese-barberry-ranunculales-berberidaceae-removal-did-not-reduce-the-abundance-of-questing-blacklegged-ticks-acari-ixodidae
#4
JOURNAL ARTICLE
Susan P Elias, Peter W Rand, Charles B Lubelczyk, Melanie R McVety, Robert P Smith
In a nature reserve in southern Maine, we removed invasive Japanese barberry (Berberis thunbergii de Candolle) along sections of forested recreational trails that ran through dense barberry infestations. Barberry thickets provide questing substrate and a protective microclimate for blacklegged ticks (Ixodes scapularis Say), and trail users could brush up against encroaching barberry and acquire ticks. Trailside barberry removal will reduce or eliminate encroaching tick questing substrate and could reduce trailside questing tick abundance by creating a microclimate more hostile to ticks...
March 16, 2024: Environmental Entomology
https://read.qxmd.com/read/38493194/influence-of-nano-bn-inclusion-and-mechanism-involved-on-aluminium-copper-alloy
#5
JOURNAL ARTICLE
Ziqi Zhang, Qi Zeng, Ning Wang, Lixia Wang, Quan Wu, Xin Li, Jiao Tang, Rong Li
Taking advantage of the high specific surface area of the nanoparticles, boron nitride (BN) nanoparticles were incorporated into the semi-solidified aluminium-copper alloy Al-5Cu-Mn (ZL201) system during the casting process, and its properties and enhancement mechanism were studied. The results shown that the BN in the new composite material is more uniformly distributed in the second phase (Al2 Cu), which can promote grain refinement and enhance the bonding with the aluminium-based interface, and the formation of stable phases such as AlB2 , AlN, CuN, etc...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493010/glycemic-variability-in-diagnosis-of-gestational-diabetes-as-predictor-of-pharmacological-treatment
#6
JOURNAL ARTICLE
Rosa Márquez-Pardo, María-Gloria Baena-Nieto, Juan-Antonio Córdoba-Doña, Concepción Cruzado-Begines, Lourdes García-García-Doncel, Manuel Aguilar-Diosdado, Isabel-María Torres-Barea
INTRODUCTION: To establish whether glycemic variability (GV) parameters used when gestational diabetes mellitus (GDM) has been diagnosed could help predict the probability that a patient will need pharmacological treatment, and to analyze the link of these parameters to the development of maternal-fetal complications. MATERIALS AND METHODS: A prospective study of 87 women with GDM who underwent retrospective continuous glucose monitoring (CGM) for six days between weeks 26 and 32 of gestation, following diagnosis...
March 16, 2024: Endocrinología, diabetes y nutrición
https://read.qxmd.com/read/38492999/benefits-and-challenges-of-18-f-fdg-pet-ct-in-patients-with-takayasu-arteritis
#7
JOURNAL ARTICLE
Z-H Luo, W-L Qi, A-F Jin, Q-Y Zeng
AIM: To evaluate the diagnostic performance of 2-[18 F]-fluoro-2-deoxy-d-glucose (18 F-FDG) positron-emission tomography (PET)/computed tomography (CT) in TA diagnosis and Takayasu arteritis (TA) activity assessment. MATERIALS AND METHODS: This retrospective study included patients with TA diagnosed according to the American College of Rheumatology (ACR) criteria and undergoing 18 F-FDG PET/CT imaging from October 2010 to July 2022. TA activity was assessed through 18 F-FDG PET/CT (maximum standard uptake value [SUVmax], vascular SUVmax/mean standard uptake value [SUVmean] of liver (SUV ratio), and PET vascular activity score [PETVAS]) using physician global assessment (PGA) as the reference standard, and the results of these assessments were compared against the clinical activity scores (National Institutes of Health [NIH] and Indian Aortitis Disease Activity [ITAS-A] scores), acute-phase reactants (APR), and white blood cell and platelet counts...
February 2, 2024: Clinical Radiology
https://read.qxmd.com/read/38492985/computer-assisted-image-analysis-of-preexisting-histological-patterns-of-the-cephalic-vein-to-predict-wrist-arteriovenous-fistula-non-maturation
#8
JOURNAL ARTICLE
Jeng-Wei Chen, Mao Ting, Po-Ya Chang, Chiau-Jing Jung, Chin-Hao Chang, Shi-Yu Fang, Li-Wei Liu, Kelvin Jeason Yang, Sz-Han Yu, Yih-Sharng Chen, Nai-Hsin Chi, Ron-Bin Hsu, Chih-Hsien Wang, I-Hui Wu, Hsi-Yu Yu, Chih-Yang Chan
BACKGROUND: We used computer-assisted image analysis to determine whether preexisting histological features of the cephalic vein influence the risk of non-maturation of wrist fistulas. METHODS: This study focused on patients aged 20-80 years who underwent their first wrist fistula creation. A total of 206 patients participated, and vein samples for Masson's trichrome staining were collected from 134 patients. From these, 94 patients provided a complete girth of the venous specimen for automatic image analysis...
March 15, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38492803/consolidation-rate-in-ulnar-shortening-osteotomy-with-the-aptus-wrist-plate
#9
JOURNAL ARTICLE
Thomas Daoulas, Mathilde Bernard, Arthur Dellestable, Hoel Lestissier, Guillaume Bacle, Clara Sos
INTRODUCTION: Ulnocarpal impaction syndrome causes pain on the ulnar side of the wrist. Various surgical techniques have been described. Ulnar shortening osteotomy is now a standard treatment. However, it is associated with complications such as non-union of the osteotomy site. The main study objective was to report the rate of radiographic consolidation after ulnar shortening osteotomy with a cutting guide. MATERIAL AND METHODS: This multicenter retrospective study of 30 cases reported clinical and radiographic criteria at a minimum 6 month's follow-up...
March 14, 2024: Hand Surgery and Rehabilitation
https://read.qxmd.com/read/38492698/flexible-biopolymer-assisted-3d-printed-bioceramics-scaffold-with-high-shape-adaptability
#10
JOURNAL ARTICLE
Xiaoqing Hu, Shanshan Li, Zhichao He, Xiaoyun Li, Xiaoying Wang
Bioceramics are widely used in bone tissue engineering, yet the inherent high brittleness and low ductility of the ceramics lead to poor machinability, which restricts their clinical applications. Here, a flexible and processable 3D printed bioceramic scaffold with high ceramic content (66.7 %) and shape fidelity (volume shrinkage rate < 5 %) was developed by freeze-thaw cycles, which was assisted by polyvinyl alcohol (PVA) and silk fibroin (SF). The hydrogen bonding between PVA imparted printability to the ceramic ink and enabled the subsequent formation of flexible scaffolds, which can be twisted, bend and cut to match bone defects...
March 14, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38492681/efficient-removal-of-ciprofloxacin-and-ofloxacin-from-aqueous-solutions-using-a-novel-nano-scale-adsorbent-modeling-optimization-and-characterization
#11
JOURNAL ARTICLE
Omid Farzinmanesh, Mina Hosseini Sabzevari, Mohammad Reza Asghari
In the fascinating realm of water purification, our study unveils the remarkable potential of a cutting-edge nano-scale adsorbent-combining graphene oxide (GO), chitosan (CS), and polydopamine (PDA)-in efficiently remove ciprofloxacin (CPF) and ofloxacin (OFL) from aqueous solutions. Our exploration delves deep into the adsorbent's character, utilizing a range of analytical techniques including SEM, RAMAN, FTIR, TGA, BET, XRD, and Zeta potential analyses provided insights into the adsorbent's properties. Modeling the adsorption process with Response Surface Methodology (RSM), Artificial Neural Network (ANN) and General Regression Neural Network (GRNN) indicated excellent predictions by GRNN, with RMSE = 0...
March 14, 2024: Chemosphere
https://read.qxmd.com/read/38492301/smart-nano-inks-based-on-natural-food-colorant-for-screen-printing-of-dynamic-shelf-life-of-shrimp
#12
JOURNAL ARTICLE
Atiyeh Mehrzad, Asma Verdian, Mahboobe Sarabi-Jamab
Intelligent packaging embedded with food freshness indicators can monitor food quality and be deployed for food safety and cutting food waste. The innovative nano-inks for dynamic shelf-life printing based on natural food colorant with application in real-time monitoring of shrimp freshness were prepared. Co-assembly of saffron petal anthocyanin (SPA) with hydrophobic curcumin (Cur) into chitin nano-scaffold (particle sizes around 26 ± 8 nm) could deliver hindering SPA leaching, confirmed by FT-IR, FE-SEM, AFM, and color stability test...
March 11, 2024: Food Chemistry
https://read.qxmd.com/read/38491826/exploring-the-relation-of-active-surveillance-schedules-and-prostate-cancer-mortality
#13
JOURNAL ARTICLE
Zhenwei Yang, Eveline A M Heijnsdijk, Lisa F Newcomb, Dimitris Rizopoulos, Nicole S Erler
BACKGROUND: Active surveillance (AS), where treatment is deferred until cancer progression is detected by a biopsy, is acknowledged as a way to reduce overtreatment in prostate cancer. However, a consensus on the frequency of taking biopsies while in AS is lacking. In former studies to optimize biopsy schedules, the delay in progression detection was taken as an evaluation indicator and believed to be associated with the long-term outcome, prostate cancer mortality. Nevertheless, this relation was never investigated in empirical data...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491825/the-outcome-in-patients-with-braf-mutated-metastatic-melanoma-treated-with-anti-programmed-death-receptor-1-monotherapy-or-targeted-therapy-in-the-real-world-setting
#14
JOURNAL ARTICLE
Jindřich Kopecký, Marek Pásek, Radek Lakomý, Bohuslav Melichar, Ivona Mrazová, Ondřej Kubeček, Monika Arenbergerová, Radmila Lemstrová, Alžběta Švancarová, Vojtěch Tretera, Alžběta Hlodáková, Kamila Žváčková
BACKGROUND: Immunotherapy and targeted therapy are currently two alternative backbones in the therapy of BRAF-mutated malignant melanoma. However, predictive biomarkers that would help with treatment selection are lacking. METHODS: This retrospective study investigated outcomes of anti-programmed death receptor-1 monotherapy and targeted therapy in the first-line setting in patients with metastatic BRAF-mutated melanoma, focusing on clinical and laboratory parameters associated with treatment outcome...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491732/synergistically-modulating-conductive-filaments-in-ion-based-memristors-for-enhanced-analog-in-memory-computing
#15
JOURNAL ARTICLE
Jinyong Wang, Yujing Ren, Ze Yang, Qiaoya Lv, Yu Zhang, Mingyue Zhang, Tiancheng Zhao, Deen Gu, Fucai Liu, Baoshan Tang, Weifeng Yang, Zhiqun Lin
Memristors offer a promising solution to address the performance and energy challenges faced by conventional von Neumann computer systems. Yet, stochastic ion migration in conductive filament often leads to an undesired performance tradeoff between memory window, retention, and endurance. Herein, a robust memristor based on oxygen-rich SnO2 nanoflowers switching medium, enabled by seed-mediated wet chemistry, to overcome the ion migration issue for enhanced analog in-memory computing is reported. Notably, the interplay between the oxygen vacancy (Vo) and Ag ions (Ag+ ) in the Ag/SnO2 /p++ -Si memristor can efficiently modulate the formation and abruption of conductive filaments, thereby resulting in a high on/off ratio (>106), long memory retention (10-year extrapolation), and low switching variability (SV = 6...
March 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38491715/helical-coil-design-with-controlled-dispersion-for-bunching-enhancement-of-protons-generated-by-the-target-normal-sheath-acceleration
#16
JOURNAL ARTICLE
A Hirsch-Passicos, C L C Lacoste, F André, Y Elskens, E D'Humières, V Tikhonchuk, M Bardon
The quality of the proton beam produced by target normal sheath acceleration (TNSA) with high-power lasers can be significantly improved with the use of helical coils. While they showed promising results in terms of focusing, their performances in terms of the of cut-off energy and bunching stay limited due to the dispersive nature of helical coils. A new scheme of helical coil with a tube surrounding the helix is introduced, and the first numerical simulations and an analytical model show a possibility of a drastic reduction of the current pulse dispersion for the parameters of high-power-laser facilities...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491707/barkhausen-noise-in-disordered-striplike-ferromagnets-experiment-versus-simulations
#17
JOURNAL ARTICLE
Djordje Spasojević, Miloš Marinković, Dragutin Jovković, Sanja Janićević, Lasse Laurson, Antonije Djordjević
In this work, we present a systematic comparison of the results obtained from the low-frequency Barkhausen noise recordings in nanocrystalline samples with those from the numerical simulations of the random-field Ising model systems. We performed measurements at room temperature on a field-driven metallic glass stripe made of VITROPERM 800 R, a nanocrystalline iron-based material with an excellent combination of soft and magnetic properties, making it a cutting-edge material for a wide range of applications...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491705/effectiveness-of-contact-tracing-on-networks-with-cliques
#18
JOURNAL ARTICLE
Abbas K Rizi, Leah A Keating, James P Gleeson, David J P O'Sullivan, Mikko Kivelä
Contact tracing, the practice of isolating individuals who have been in contact with infected individuals, is an effective and practical way of containing disease spread. Here we show that this strategy is particularly effective in the presence of social groups: Once the disease enters a group, contact tracing not only cuts direct infection paths but can also pre-emptively quarantine group members such that it will cut indirect spreading routes. We show these results by using a deliberately stylized model that allows us to isolate the effect of contact tracing within the clique structure of the network where the contagion is spreading...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491645/surface-stress-can-initiate-environment-assisted-fracture-in-metals
#19
JOURNAL ARTICLE
Anirudh Udupa, Debapriya Pinaki Mohanty, Tatsuya Sugihara, James B Mann, Ronald M Latanision, Srinivasan Chandrasekar
Controlling environmental effects in surface plasticity/fracture of metals is of interest for areas as diverse as manufacturing processes, product performance, and structural safety. The key to controlling these effects is understanding the effect of adsorbates on surface energy (γ) and surface stress (f). While γ has been well studied, the role of surface stress has received much less attention. We characterize surface stress induced in metals by adsorption of organic monolayers. Linear alkanoic acids of varying chain length (3-18) are deposited by molecular self-assembly onto one side of an aluminum cantilever, several centimeters in length...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491534/a-novel-machine-learning-framework-based-on-early-embryo-morphokinetics-identifies-a-feature-signature-associated-with-blastocyst-development
#20
JOURNAL ARTICLE
S Canosa, N Licheri, L Bergandi, G Gennarelli, C Paschero, M Beccuti, D Cimadomo, G Coticchio, L Rienzi, C Benedetto, F Cordero, A Revelli
BACKGROUND: Artificial Intelligence entails the application of computer algorithms to the huge and heterogeneous amount of morphodynamic data produced by Time-Lapse Technology. In this context, Machine Learning (ML) methods were developed in order to assist embryologists with automatized and objective predictive models able to standardize human embryo assessment. In this study, we aimed at developing a novel ML-based strategy to identify relevant patterns associated with the prediction of blastocyst development stage on day 5...
March 15, 2024: Journal of Ovarian Research
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