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https://www.readbyqxmd.com/read/29045176/computer-aided-diagnosis-of-ground-glass-opacity-nodules-using-open-source-software-for-quantifying-tumor-heterogeneity
#1
Ming Li, Vivek Narayan, Ritu R Gill, Jyothi P Jagannathan, Maria F Barile, Feng Gao, Raphael Bueno, Jagadeesan Jayender
OBJECTIVE: The purposes of this study are to develop quantitative imaging biomarkers obtained from high-resolution CTs for classifying ground-glass nodules (GGNs) into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC); to evaluate the utility of contrast enhancement for differential diagnosis; and to develop and validate a support vector machine (SVM) to predict the GGN type. MATERIALS AND METHODS: The heterogeneity of 248 GGNs was quantified using custom software...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29044713/investigation-of-umbilical-venous-vessels-anatomy-and-diameters-as-a-guideline-for-catheter-placement-in-newborns
#2
F Eifinger, Z Fuchs, F Koerber, T Persigehl, M Scaal
INTRODUCTION: Umbilical cord catheters (UCC) are important for the primary care of critically ill newborns. To analyze anatomical variations of the umbilical vein (UV) and its further course, we performed abdominal spiral-CT examinations on stillborns. The aim of the study was to explore the high incidence of mal-positioned UCCs and to improve their positioning. MATERIALS AND METHODS: Eighteen stillborns were investigated (29.2 weeks ± 6.7 weeks (IQR)). CTs were performed using either air or contrast medium injection into the UV...
October 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29043402/imaging-characterization-of-adnexal-lesions-do-ct-findings-correlate-with-us
#3
Akshay D Baheti, Cory E Lewis, Daniel S Hippe, Ryan B O'Malley, Carolyn L Wang
OBJECTIVE: To compare contrast-enhanced CT and US agreement in characterizing adnexal lesions in late post-menopausal women. MATERIALS AND METHODS: This was a HIPAA-compliant IRB-approved retrospective review of the contrast-enhanced CTs of 130 late post-menopausal women (> 55 years). The lesions were classified as simple cystic, minimally complex cystic, complex cystic, solid-cystic, or solid based on CT and US morphology. Findings were analyzed to evaluate agreement between CT and US on adnexal lesion characterization...
October 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29041021/a-comparison-of-outcomes-of-carpal-tunnel-release-for-carpal-tunnel-syndrome-in-patients-diagnosed-with-and-without-electrophysiological-studies
#4
Piotr Puchalski, Andrzej Zyluk, Zbigniew Szlosser
Records were analysed from the institutional database, including 943 patients (1089 hands) with CTS who were operated on in the authors' department over a period of four years (2012 to 2015). The diagnosis of CTS was made solely on the basis of clinical findings in 551 patients (58 %); 392 patients (42 %) also had electrodiagnostic tests performed, for various reasons. Patients were followed-up at 1 and 6 months with assessments that included the Levine scores, filament tests, grip and pinch strength. No significant differences in Levine scores were found at the 1 and 6 month assessments...
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29039812/molecular-aspects-of-circadian-pharmacology-and-relevance-for-cancer-chronotherapy
#5
REVIEW
Narin Ozturk, Dilek Ozturk, Ibrahim Halil Kavakli, Alper Okyar
The circadian timing system (CTS) controls various biological functions in mammals including xenobiotic metabolism and detoxification, immune functions, cell cycle events, apoptosis and angiogenesis. Although the importance of the CTS is well known in the pharmacology of drugs, it is less appreciated at the clinical level. Genome-wide studies highlighted that the majority of drug target genes are controlled by CTS. This suggests that chronotherapeutic approaches should be taken for many drugs to enhance their effectiveness...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29035230/a-deep-machine-learning-method-for-classifying-cyclic-time-series-of-biological-signals-using-time-growing-neural-network
#6
Arash Gharehbaghi, Maria Linden
This paper presents a novel method for learning the cyclic contents of stochastic time series: the deep time-growing neural network (DTGNN). The DTGNN combines supervised and unsupervised methods in different levels of learning for an enhanced performance. It is employed by a multiscale learning structure to classify cyclic time series (CTS), in which the dynamic contents of the time series are preserved in an efficient manner. This paper suggests a systematic procedure for finding the design parameter of the classification method for a one-versus-multiple class application...
October 12, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29031436/detection-of-concentric-left-ventricular-wall-hypertrophy-by-contrast-enhanced-non-electrocardiogram-gated-chest-computed-tomography
#7
Andrew Yen, Jennifer Feneis, Luis R Castellanos
BACKGROUND: No established measure of concentric left ventricular wall hypertrophy (cLVH) on routine computed tomography (CT) of the adult chest currently exists. The objective of this study was to identify and test linear measures for the detection of cLVH using transthoracic echocardiography (TTE) as the reference standard. METHODS: Contrast-enhanced non-electrocardiogram-gated chest CTs acquired within two weeks of TTE were retrospectively evaluated. Two radiologists independently made trans-axial measurements in the proximal half of the left ventricle at its approximate widest internal diameter: maximum septal thickness (sept), maximum lateral wall thickness (lat), and inner (Id) and outer (Od) wall-wall diameters at the level of greatest combined myocardial thickness...
September 23, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29030781/clinical-and-imaging-features-in-lung-torsion-and-description-of-a-novel-imaging-sign
#8
Mark M Hammer, Rachna Madan
PURPOSE: We set out to identify the clinical and imaging features seen in lung torsion, a rare but emergent diagnosis leading to vascular compromise of a lobe or entire lung. METHODS: We retrospectively identified 10 patients with torsion who underwent chest CT. We evaluated each case for the presence of bronchial obstruction and abnormal fissure orientation. In seven patients who underwent contrast-enhanced CTs, we assessed for the presence of the antler sign, a novel sign seen on axial images demonstrating abnormal curvature of the artery and branches originating on one side...
October 13, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29030411/global-shortage-of-neonatal-and-paediatric-antibiotic-trials-rapid-review
#9
Georgina Thompson, Charlotte I Barker, Laura Folgori, Julia A Bielicki, John S Bradley, Irja Lutsar, Mike Sharland
OBJECTIVES: There have been few clinical trials (CTs) on antibiotics that inform neonatal and paediatric drug labelling. The rate of unlicensed and off-label prescribing in paediatrics remains high. It is unclear whether the current neonatal and paediatric antibiotic research pipeline is adequate to inform optimal drug dosing. Using the ClinicalTrials.gov registry, this review aims to establish the current global status of antibiotic CTs in children up to 18 years of age. METHODS: Studies were identified using key word searches of the ClinicalTrials...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29029203/prognostic-significance-of-computed-tomography-criteria-for-pulmonary-veno-occlusive-disease-in-systemic-sclerosis-pulmonary-arterial-hypertension
#10
Michelle J Connolly, Sharif Abdullah, Deborah A Ridout, Benjamin E Schreiber, Jamanda A Haddock, J Gerry Coghlan
Objectives: SSc-pulmonary arterial hypertension (SSc-PAH) is associated with worse response to therapy and survival when compared with idiopathic PAH. It is suggested that the vasculopathy in SSc may involve postcapillary pulmonary venules resulting in pulmonary veno-occlusive disease (PVOD). This may underlie the lower gas transfer and worse outcome on therapy. We sought to test whether CT signs of PVOD (CTS-PVOD) were frequent in SSc-PAH and whether they were associated with pulmonary oedema on therapy and worse survival...
September 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/29026941/neutral-alignment-leads-to-higher-knee-society-scores-after-total-knee-arthroplasty-in-preoperatively-non-varus-patients-a-prospective-clinical-study-using-3d-ct
#11
Omer Slevin, Anna Hirschmann, Filippo F Schiapparelli, Felix Amsler, Rolf W Huegli, Michael T Hirschmann
PURPOSE: The optimal coronal alignment is still under debate. However, in most of the studies, alignment was only assessed using radiographs, which are not accurate enough for assessment of tibial and femoral TKA position. The primary purpose of this study was to assess the relationship between coronal TKA alignment using 3D-reconstructed CTs and clinical outcome in patients with preoperative varus in comparison with patients with natural or valgus deformity. It was the hypothesis that neutral limb alignment shows a better outcome after TKA...
October 12, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29026817/comparing-the-use-of-3d-photogrammetry-and-computed-tomography-in-assessing-the-severity-of-single-suture-nonsyndromic-craniosynostosis
#12
Olivia A Ho, Nikoo Saber, Derek Stephens, April Clausen, James Drake, Christopher Forrest, John Phillips
PURPOSE: Single-suture nonsyndromic craniosynostosis is diagnosed using clinical assessment and computed tomography (CT). With increasing awareness of the associated risks of radiation exposure, the use of CT is particularly concerning in patients with craniosynostosis since they are exposed at a younger age and more frequently than the average child. Three-dimensional (3D) photogrammetry is advantageous-it involves no radiation, is conveniently obtainable within clinic, and does not require general anaesthesia...
May 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29020669/evidence-suggesting-the-end-of-universal-domestic-asbestos-exposure-in-metsovo-nw-greece
#13
Athena Gogali, Evangelia E Ntzani, Carmen Manda-Stachouli, Sofia Peristeri, Loukia Tzarouchi, Elpiniki Laiou, Athanasios Konstantinidis, Stavros H Constantopoulos, Yotanna Dalavanga
BACKGROUND: Inhabitants of Metsovo, NW Greece, had been domestically exposed to asbestos from a gradually abandoned whitewash ("luto") that resulted in a declining epidemic of malignant mesothelioma. OBJECTIVES: We aimed to evaluate whether other sources of asbestos exposure exist following "luto" abandonment. METHODS: Chest computed tomography (CT) and bronchoalveolar lavage (BAL) were used to evaluate residual asbestos exposure in younger Metsovites through the identification of pleural calcifications and asbestos bodies, respectively...
October 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29019807/pedicle-screw-insertion-accuracy-using-o-arm-robotic-guidance-or-freehand-technique-a-comparative-study
#14
Pietro Aniello Laudato, Katarzyna Pierzchala, Constantin Schizas
STUDY DESIGN: Retrospective radiological study OBJECTIVE.: To evaluate the accuracy of pedicle screw insertion using O-Arm navigation, Robotic assistance or a freehand fluoroscopic technique. SUMMARY OF BACKGROUND DATA: Pedicle screw insertion using either 'O-Arm' navigation or robotic devices is gaining popularity. Although several studies are available evaluating each of those techniques separately, no direct comparison has been attempted. METHODS: 84 patients undergoing implantation of 569 lumbar and thoracic screws were divided in three groups...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/29018941/pulmonary-arteriovenous-malformations-in-hereditary-haemorrhagic-telangiectasia-correlations-between-computed-tomography-findings-and-cerebral-complications
#15
Johan Etievant, Salim Si-Mohamed, Nicolas Vinurel, Sophie Dupuis-Girod, Evelyne Decullier, Delphine Gamondes, Chahera Khouatra, Vincent Cottin, Didier Revel
OBJECTIVES: Computed tomography (CT) is the modality of choice to characterise pulmonary arteriovenous malformations (PAVMs) in patients with hereditary haemorrhagic telangiectasia (HHT). Our objective was to determine if CT findings were associated with frequency of brain abscess and ischaemic stroke. METHODS: This retrospective study included patients with HHT-related PAVMs. CT results, i.e. PAVM presentation (unique, multiple, disseminated or diffuse), the number of PAVMs and the largest feeding artery size, were correlated to prevalence of ischaemic stroke and brain abscess...
October 10, 2017: European Radiology
https://www.readbyqxmd.com/read/29017511/mechanical-wrist-traction-as-a-non-invasive-treatment-for-carpal-tunnel-syndrome-a-randomized-controlled-trial
#16
Margreet Meems, Viola Spek, Willem J Kop, Berend-Jan Meems, Leo H Visser, Victor J M Pop
BACKGROUND: Carpal tunnel syndrome (CTS) is a common, compressive nerve-entrapment disorder with symptoms of numbness, paresthesia, and pain. Carpal tunnel release surgery is the only known long-term effective treatment. However, surgery is invasive and up to 30% of patients report recurrence or persistence of symptoms or suffer from post-surgical complications. A promising non-surgical treatment for CTS is mechanical wrist traction. The purpose of this study was to evaluate clinical outcomes following mechanical traction in patients with CTS compared to care as usual...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28994415/sci-peer-health-coach-influence-on-self-management-with-peers-a-qualitative-analysis
#17
S E Skeels, D Pernigotti, B V Houlihan, T Belliveau, M Brody, J Zazula, S Hasiotis, S Seetharama, D Rosenblum, A Jette
STUDY DESIGN: A process evaluation of a clinical trial. OBJECTIVES: To describe the roles fulfilled by peer health coaches (PHCs) with spinal cord injury (SCI) during a randomized controlled trial research study called 'My Care My Call', a novel telephone-based, peer-led self-management intervention for adults with chronic SCI 1+ years after injury. SETTING: Connecticut and Greater Boston Area, MA, USA. METHODS: Directed content analysis was used to qualitatively examine information from 504 tele-coaching calls, conducted with 42 participants with SCI, by two trained SCI PHCs...
October 10, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28993935/treatment-outcome-in-patients-with-clinically-defined-carpal-tunnel-syndrome-but-normal-electrodiagnostic-test-results-a-randomized-controlled-trial
#18
Floriaan G C M De Kleermaeker, Jan Meulstee, Franka Claes, Kristel M Kasius, Wim I M Verhagen
Little is known about treatment effect of carpal tunnel release in patients with clinically defined carpal tunnel syndrome (CTS), but normal electrodiagnostic test results (EDX). The aim of this study was to determine whether this category of patients will benefit from surgical treatment. 57 patients with clinically defined CTS and normal EDX were randomized for surgical treatment (n = 39) or non-surgical treatment (n = 18). A six-point scale for perceived improvement as well as the Boston Carpal Tunnel Questionnaire was completed at baseline and at follow-up after 6 months...
October 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28992938/bilateral-carpal-tunnel-syndrome-a-review
#19
REVIEW
Pawel Dec, Andrzej Zyluk
Carpal tunnel syndrome (CTS) is the most common upper extremity compressive neuropathy, with a prevalence of 3%-5% in the general population, and 6% in the group of females over the age of 40. It occurs about five times more common in females, with 2 peaks observed, in the 6th and 8th decades of life. Bilateral manifestation is more common than unilateral (60%), but significantly more often begins or is more strongly expressed in the dominant hand. Possible anatomical abnormalities underlying the development of CTS account for about 5% of cases...
October 2, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28990854/impact-of-membrane-partitioning-on-the-spatial-structure-of-an-s-type-cobra-cytotoxin
#20
Peter V Dubovskii, Maxim A Dubinnyi, Pavel E Volynsky, Yulia E Pustovalova, Anastasia G Konshina, Yuri N Utkin, Alexander S Arseniev, Roman G Efremov
Cobra cytotoxins (CTs) belong to the three-fingered protein family. They are classified into S- and P-types, the latter exhibiting higher membrane-perturbing capacity. In this work we investigated the interaction of CTs with phospholipid bilayers, using coarse-grained (CG) and full-atom (FA) molecular dynamics (MD). The object of this work is a CT of an S-type, cytotoxin I (CT1) from N.oxiana venom. Its spatial structure in aqueous solution and in the micelles of dodecylphosphocholine (DPC) were determined by (1)H-NMR spectroscopy...
October 9, 2017: Journal of Biomolecular Structure & Dynamics
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