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Benedito Felipe Rabay Pimentel, Flávio Faloppa, Marcel Jun Sugawara Tamaoki, João Carlos Belloti
BACKGROUND: The aim of this study was to evaluate the effectiveness of two diagnostic tests routinely used for diagnosing carpal tunnel syndrome (CTS)-ultrasonography (US) and nerve conduction studies (NCS)-by comparing their accuracy based on surgical results, with the remission of paresthesia as the reference standard. METHODS: We enrolled 115 patients, all of the female gender with a high probability of a clinical diagnosis of CTS. All patients underwent US and NCS for a diagnosis and subsequent surgical treatment...
April 12, 2018: BMC Musculoskeletal Disorders
P Garcia-Sanchez, R Lopez-Lopez, L Rubio-Gordon, B Rosich-Del Cacho, L Tesouro-Rodriguez, M A Rivas-Paterna, M A Perez-Moneo Agapito, S Garcia-Garcia
AIM: To describe the clinical presentation, risk factors and complementary tests in patients of our paediatric emergency service with a final diagnosis of ischemic stroke. PATIENTS AND METHODS: Retrospective, analytical and observational study, performed in a Paediatric Emergency Service of a tertiary-level hospital. We included patients aged 1 month to 14 years during a 12-years period with a final diagnosis of ischemic cerebrovascular disease (CVD). We analyzed personal history, symptomatology and initial complementary tests...
April 16, 2018: Revista de Neurologia
Greesh Kumar Singh, Sanjay Srivastava
The main objective of the present work was to determine the association of grip strength with carpal tunnel syndrome (CTS) for occupational workers exposed to the risk of CTS. Experiments were performed on sixty workers, fifteen from each occupation. Grip strength was measured using hand dynamometer. Electrophysiological experiments were conducted to measure CTS. Three levels of CTS were identified on the basis of latency value and motor nerve conduction velocity, viz., mild, moderate, and severe. Statistical results suggest that workers having CTS lose their grip strength, and higher levels of CTS lead to greater reduction in the grip strength...
April 12, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
Maryam Qureshi, Erin Zelinski, Linda E Carlson
BACKGROUND: Cancer survivors use complementary therapies (CTs) for a variety of reasons; however, with interest and use reportedly on the rise and a widening range of products and practices available, there is a need to establish trends in and drivers of interest. We aimed to determine (1) frequencies of use, level of interest, and barriers for 30 specific CTs and (2) whether physical symptoms, perceived stress (PS), or spiritual well-being were related to interest levels. METHOD: A total of 212 cancer outpatients were surveyed at the Tom Baker Cancer Centre in Calgary, Canada...
April 1, 2018: Integrative Cancer Therapies
Bionka Ma Huisstede, Manon S Randsdorp, Janneke van den Brink, Thierry Pc Franke, Bart W Koes, Peter Hoogvliet
OBJECTIVE: To present an evidence-based overview of the effectiveness of oral pain medication and corticosteroid injections to treat carpal tunnel syndrome (CTS). DATA SOURCES: The Cochrane Library, PubMed, EMBASE, CINAHL, and PEDro were searched for relevant systematic reviews and randomized controlled trials (RCTs). DATA SELECTION AND EXTRACTION: Two reviewers independently selected the studies, extracted the data on pain (VAS), function or recovery and assessed the methodological quality...
April 4, 2018: Archives of Physical Medicine and Rehabilitation
Md Abdus Shabur Talukder, Ahmed Zaky Balboula, Takahiro Shirozu, Sung-Woo Kim, Hiroki Kunii, Toshiyuki Suzuki, Tsukino Ito, Koji Kimura, Masashi Takahashi
In ruminants, interferon-tau (IFNT)-mediated expression of interferon-stimulated genes in peripheral blood leukocytes (PBLs) can indicate pregnancy. Recently, type 1 IFN-mediated activation of lysosomes and lysosomal cathepsins (CTSs) was observed in immune cells. This study investigated the status of lysosomal CTSs and lysosomes in PBLs collected from pregnant (P) and non-pregnant (NP) dairy cows, and conducted in vitro IFNT-stimulation of NP blood leukocytes. Blood samples were collected 0, 7, 14, and 18 days post-artificial insemination, and the peripheral blood mononuclear cells (PBMCs) and polymorphonuclear granulocytes (PMNs) separated...
April 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Russell K McIntire, Scott W Keith, Maxwell Boamah, Amy E Leader, Karen Glanz, Ann C Klassen, Charnita M Zeigler-Johnson
This study presents a novel geo-based metric to identify neighborhoods with high burdens of prostate cancer, and compares this metric to other methods to prioritize neighborhoods for prostate cancer interventions. We geocoded prostate cancer patient data (n = 10,750) from the Pennsylvania cancer registry from 2005 to 2014 by Philadelphia census tract (CT) to create standardized incidence ratios (SIRs), mortality ratios (SMRs), and mean prostate cancer aggressiveness. We created a prostate cancer composite (PCa composite) variable to describe CTs by mean-centering and standard deviation-scaling the SMR, SIR, and mean aggressiveness variables and summing them...
April 3, 2018: Preventive Medicine
E S Mahdi, M T Whitehead
BACKGROUND AND PURPOSE: CHARGE syndrome is a multisystemic congenital disorder, most commonly including coloboma, heart malformations, choanal atresia, developmental delay, and genital and ear anomalies. The diagnostic criteria for CHARGE syndrome have been refined with time. However, limited reports describe skull base and craniocervical junction abnormalities. Recently, a coronal clival cleft has been identified in association with CHARGE syndrome. The aim of our study was to assess the prevalence of clival pathology in CHARGE syndrome...
April 5, 2018: AJNR. American Journal of Neuroradiology
Jorunn Sandvik, Torstein Hole, Christian A Klöckner, Bård E Kulseng, Arne Wibe
INTRODUCTION: Acute, intermittent, and chronic abdominal pain is a common complaint after Roux-en-Y gastric bypass (RYGB). OBJECTIVES: The aim of the study was to evaluate the use of medical imaging and the need for surgery treating abdominal pain after RYGB in a cohort with long-term follow-up. METHODS: Data from 569 patients who underwent RYGB as the primary bariatric procedure at a public hospital in Norway between April 2004 and June 2011 were prospectively registered in a local quality registry for bariatric surgery...
April 4, 2018: Obesity Surgery
Dinesh J Bhanderi, Daxa G Mishra, Shweta M Parikh, Deepak B Sharma
Context: Carpal tunnel syndrome (CTS) is one of the musculoskeletal disorders that is often described as an occupational hazard, including occupations involving computer use. However, clear consensus is lacking as far as the association between the use of computer and risk of possible CTS is concerned. Aim: To assess the association between CTS and computer use. Settings and Design: A case-control study. Materials and Methods: A sample size of 411 (137 cases and 274 controls) was calculated using Epi Info (version 6)...
September 2017: Indian Journal of Occupational and Environmental Medicine
Sushil Ramesh Nehete, Binita B Raut, Amita S Hiremath, R Mukund Thatte
Objective: We aimed to study the various clinical and electrophysiological parameters of severity of carpal tunnel syndrome (CTS) and to see if the severity of CTS affects recovery after surgery. Patients and Methods: A prospective study of 35 patients suffering from CTS. Clinical severity was assessed using visual analogue scale and standard questionnaires such as Levine and Disabilities of Arm, Shoulder and Hand questionnaires. All the patients underwent electrophysiological evaluation to assess electrophysiological severity of CTS...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
A V Lopachev, O M Lopacheva, K A Nikiforova, I S Filimonov, T N Fedorova, E E Akkuratov
Binding to Na+,K+-ATPase, cardiotonic steroids (CTS) activate intracellular signaling cascades that affect gene expression and regulation of proliferation and apoptosis in cells. Ouabain is the main CTS used for studying these processes. The effects of other CTS on nervous tissue are practically uncharacterized. Previously, we have shown that ouabain affects the activation of mitogen-activated protein kinases (MAP kinases) ERK1/2, p38, and JNK. In this study, we compared the effects of digoxin and bufalin, which belong to different subclasses of CTS, on primary culture of rat cortical cells...
February 2018: Biochemistry. Biokhimii︠a︡
James Farrell, Enrique Garrido
Introduction: High prevalence of obstructive lung disease has been reported in patients undergoing surgical correction of thoracic scoliosis. Airway narrowing due to spine morphology is analysed as a contributing factor. Methods: Preoperative surgical planning CTs of 34 patients with right-sided thoracic scoliosis (age: 17.6±9.0) were retrospectively analysed and compared with 15 non-scoliotic controls (age: 16.3±5.1). Three-dimensional models of spine and airway lumen were reconstructed...
2018: BMJ Open Respiratory Research
Deepak Chatterjee, Lewis Lu Zhiping, Suet-Mien Tan, Surajit Bhattacharjya
Integrins are transmembrane proteins that mediate cell adhesion and migration. Each integrin is a heterodimer formed by an α and a β subunit. A large number of cytoplasmic proteins interact with the cytoplasmic tails (CTs) of integrins. The actin-binding cytoskeletal protein filamin A is a negative regulator of integrin activation. The IgFLNa21 domain of filamin A binds to the C-terminus of β2 CT that contains a TTT-motif. Based on x-ray crystallography, it has been reported that the integrin β2 CT forms a β strand that docks into the β strands C and D of IgFLNa21...
April 3, 2018: Scientific Reports
Emily Kobayashi, Bennett Johnson, Kathleen Goetz, James Scanlan, Robert Weinsheimer
BACKGROUND: Efficacy of care pathways for pediatric appendicitis is well established in children's hospitals, but not in community Emergency Departments (EDs). METHODS: A diagnostic pathway combining the Pediatric Appendicitis Score (PAS) with selective ultrasound was implemented. The charts of 2201 pediatric patients seen at four general EDs before and after implementation were retrospectively reviewed, identifying 611 children seriously considered for appendicitis...
March 17, 2018: American Journal of Surgery
Xuan-Yan Guo, Mao-Xiang Xiong, Man Lu, Xue-Qing Cheng, Yan-Yan Wu, Shi-Yin Chen, Kai Chen, Qiao-Dan Zhou, Lei Wang, Li Tan, Jie-Rong Quan, Fan-Ding He, Qin Chen
BACKGROUND: To compare the clinical effectiveness of ultrasound-guided needle release of the transverse carpal ligament (TCL) with and without corticosteroid injection in carpal tunnel syndrome (CTS). METHODS: From June 2016 to June 2017, 49 CTS patients (50 wrists) were included in this study. Twenty-five wrists were treated with ultrasound-guided needle release of the TCL plus corticosteroid injection (group A), and 25 wrists were treated with single ultrasound-guided needle release of the TCL (group B)...
April 3, 2018: Journal of Orthopaedic Surgery and Research
Murat Alemdar
BACKGROUND: Comparison of sensory conduction of median nerve (MN) with the one of ulnar nerve (UN) over writs-to-ring finger (RF) segment is useful in electrodiagnosis of carpal tunnel syndrome (CTS). However, there is not any consensus regarding the usage of this technique in grading of CTS. OBJECTIVES: To determine whether the hands of CTS with elicitable MN sensory responses on index finger, but not on RF (non-respondings) compose a more severe electrophysiologic grade than the hands with elicitable responses on both fingers (respondings)...
March 23, 2018: Journal of Back and Musculoskeletal Rehabilitation
Keiji Nogami, Tomoko Matsumoto, Koji Yada, Kenichi Ogiwara, Shoko Furukawa, Yasuaki Shida, Masahiro Takeyama, Midori Shima
Bypassing therapy is essential for the haemostatic management of patients with haemophilia A with inhibitor (PWHA-inh), but the therapeutic effects are inconsistent. We previously reported that activated prothrombin complex concentrates (aPCC) activated factor (F)VIIIin vitro, and was mediated mainly by the activated FVII (FVIIa) contained in aPCC. We have extended those studies to assess global coagulation in whole blood from 18 PWHA-inh in the co-presence of aPCC and FVIII using Ca2+ -triggered rotational thromboelastometry...
April 2, 2018: British Journal of Haematology
Luigi Arcieri, Raffaele Giordano, Ermanno Bellanti, Dante Chiappino, Bruno Murzi
Congenital tracheal stenosis (CTS) is rare lesions frequently associated with pulmonary sling (PS). Despite the recent improvement in the results by the introduction of slide tracheoplasty (ST) and multidisciplinary approach, surgical management remains difficult and several authors, for this reason, debate for a conservative approach in these cases. Preoperative planning, require hence the use of the most innovative technology to gain the best possible result. This report describes a complicated, unsuccessful surgically treated case of CTS associated to PS...
February 2018: Journal of Thoracic Disease
Yuki Yoshimatsu, Ryuhei Morita, Miho Suginaka, Koichi Furukawa, Naoki Nakamura, Kazushi Yamairi, Naomi Maruyama, Masahide Kaji, Takao Kamimori, Hiroshi Fujiwara
Congenital tracheal stenosis (CTS) is a rare disorder almost always diagnosed in infancy due to respiratory failure and other cardiopulmonary abnormalities. We experienced a 42-year-old female undiagnosed with CTS until difficult intubation upon surgery. Chest X-ray and computed tomography (CT) images revealed bronchial narrowing, which could already be seen prior to intubation, but was left unnoticed. Difficult airway management is a potentially lethal airway emergency. This life-threatening situation is preventable with the appropriate awareness...
February 2018: Journal of Thoracic Disease
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