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https://www.readbyqxmd.com/read/28647880/selective-removal-and-preconcentration-of-triclosan-using-a-water-compatible-imprinted-nano-magnetic-chitosan-particles
#1
Yuan Chen, Xin Lei, Rongni Dou, Yuancai Chen, Yongyou Hu, Zhiqi Zhang
A water-compatible magnetic triclosan (TCS) imprinted material (TCS-CTS-Fe(0)-MIPs) was synthesized for selective enrichment and detection of TCS in real complex water samples. The material was synthesized by using chitosan (CTS) as functional monomer, which has rich surface O- and N-containing functional groups. The TCS imprinted CTS was coated on Fe(0) surface and then cross-linked with glutaraldehyde. Scanning electron microscopy suggested that the imprinted material was covered with a layer of imprinted film, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed that the imprinted material had more functional groups (amino and hydroxyl groups) than that of non-imprinted material...
June 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28643318/-experimental-research-of-neutrophil-gelatinase-associated-lipocalin-sirna-encapsulated-by-urocanic-acid-coupled-chitosan-on-colon-cancer-cells
#2
Zhong Shen, Kan Xu, Houdong Wang, Guangen Yang, Jieli Pan, Meiya Li, Jianming Qiu, Wenjing Wu, Ying Zhang, Xiufeng Zhang
OBJECTIVE: To explore the impact of neutrophil gelatinase-associated lipocalin (NGAL) knockdown by NGAL siRNA encapsulated with urocanic acid-modified chitosan nanoparticles (UAC) on the proliferation, migration and apoptosis of human colon cancer cells. METHODS: NGAL siRNA was encapsulated by UAC and chitosan (CTS) respectively, and then was transfected into human colon cancer cell lines HT29. The NGAL mRNA was detected by real-time quantitative PCR (RT-QPCR). Relationships of NGAL gene silencing with the proliferation, migration and apoptosis of HT29 cell were analyzed...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28643093/the-impact-of-trained-radiographers-as-concurrent-readers-on-performance-and-reading-time-of-experienced-radiologists-in-the-uk-lung-cancer-screening-ukls-trial
#3
Arjun Nair, Nicholas J Screaton, John A Holemans, Diane Jones, Leigh Clements, Bruce Barton, Natalie Gartland, Stephen W Duffy, David R Baldwin, John K Field, David M Hansell, Anand Devaraj
OBJECTIVES: To compare radiologists' performance reading CTs independently with their performance using radiographers as concurrent readers in lung cancer screening. METHODS: 369 consecutive baseline CTs performed for the UK Lung Cancer Screening (UKLS) trial were double-read by radiologists reading either independently or concurrently with a radiographer. In concurrent reading, the radiologist reviewed radiographer-identified nodules and then detected any additional nodules...
June 22, 2017: European Radiology
https://www.readbyqxmd.com/read/28640660/chromosome-territory-relocation-paradigm-during-dna-damage-response-some-insights-from-molecular-biology-to-physics
#4
Sarosh N Fatakia, Mugdha Kulashreshtha, Ishita S Mehta, Basuthkar J Rao
Among the many facets of DNA damage response (DDR), relocation of chromosome territories (CTs) is most intriguing. We have previously reported that cisplatin induced DDR in human dermal fibroblasts led to relocation of CTs 12, 15 from the nuclear periphery to its interior while CTs 19, 17 repositioned from the interior to its periphery. Studies of CT relocation remain nascent as we begin unraveling the role of key players in DDR to demonstrate its mechanistic basis. Consolidating our recent reports, we argue that γH2AX-signaling leads to enhanced recruitment of nuclear myosin 1 (NM1) to chromatin, which via its motor function, results in CT repositioning...
June 22, 2017: Nucleus
https://www.readbyqxmd.com/read/28640120/working-hand-syndrome-a-new-definition-of-non-classified-polyneuropathy-condition
#5
Gökhan Özdemir
The aim of this paper was to define an unexplained non-classified polyneuropathy condition as a new neurological disease. This new diagnosis of occupation related polyneuropathy has been named as "WORKING HAND SYNDROME (WHS)."This study collected and compared clinic and electrophysiological analyze data from healthy controls, WHS patients, carpal tunnel syndrome (CTS) patients and polyneuropathy patients. The WHS patients presented to the clinic with pain, numbness, tingling, and burning sensations in their hands that increased significantly during rest and nighttime...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28634858/distal-pain-and-carpal-tunnel-syndrome-diagnosis-among-cashiers-a-longitudinal-study
#6
Roberto Meroni, Paola Alberti, Paola Boria, Simone Giordano, Guido Cavaletti
OBJECTIVE: To estimate in a longitudinal study the yearly incidence of carpal tunnel syndrome (CTS) in a cohort of women working as cashiers. METHOD: A total of 198 cashiers, belonging to a cohort investigated in 2011-2012 for arm pain, were screened for re-assessment in 2015 (at least 40 months from the first examination), and 156 women had complete demographic, personal and working data allowing to be included in this study. On the basis of self- and clinician-administered questionnaires investigating the presence of CTS, all symptomatic patients underwent clinical and neurophysiological [nerve conduction studies (NCS) of median and ulnar nerves] assessments...
June 20, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28628810/gh-administration-decreases-subcutaneous-abdominal-adipocyte-size-in-men-with-abdominal-obesity
#7
Miriam A Bredella, Kalypso Karastergiou, Stijn A Bos, Anu V Gerweck, Martin Torriani, Susan K Fried, Karen K Miller
OBJECTIVE: To investigate the effects of short-term GH administration on abdominal subcutaneous adipocyte size and CT attenuation in men with abdominal obesity. DESIGN: 6-week, randomized, double-blind, placebo-controlled study of GH (starting dose 2μg/kg/d) vs placebo of 15 abdominally obese men (mean age: 34±6years; mean BMI: 37.7±6.1kg/m(2), mean IGF-1 SDS: -1.9±0.5) who underwent abdominal subcutaneous adipose tissue (SAT) aspirations to determine adipocyte size, CTs for body composition and measures of glucose tolerance at baseline and 6weeks...
June 12, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28627755/labeling-dna-replication-foci-to-visualize-chromosome-territories-in-vivo
#8
Apolinar Maya-Mendoza, Dean A Jackson
While a detailed understanding of chromatin dynamics is needed to explain how higher-order chromatin organization influences nuclear function, the molecular principles that regulate chromatin mobility in mammalian nuclei remain largely unknown. Here we describe experimental tools to follow chromatin dynamics by labeling DNA during S phase. Using these methods, we have found that foci labeled during early and mid/late S phase have significantly different dynamic behavior. Spatially constrained heterochromatic foci restrict long-range transformations of the chromosome territory (CT) structure while providing a structural framework on which highly mobile euchromatic foci undergo positional oscillations that drive local changes in the chromosome shape...
June 19, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/28627507/semivertical-incision-an-aesthetically-and-electrophysiologically-effective-mini-incision-technique-for-carpal-tunnel-decompression
#9
Nese Keser, Nimet Dortcan, Ulas Cikla, Kutluay Uluc, Erhan Celikoglu, Merih Is, Bora Gurer
BACKGROUND The purpose of this study was to present the clinical results of our retrospective series of carpal tunnel release (CTR) operations. For these operations we used a unique type of incision, for the first time, for treatment of carpal tunnel syndrome (CTS) consisting of a 1-cm semi-vertical (SV) incision made into the wrist crease for macroscopic open CTR. MATERIAL AND METHODS This retrospective study included 114 patients (101 females and 13 males) with CTR who were operated upon in our neurosurgery clinic between December 2010 and June 2015...
June 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28625649/investigation-of-patterns-of-nodal-metastases-in-braf-mutant-lung-cancer
#10
S H McEvoy, D F Halpenny, A Viteri-Jusué, S A Hayes, A J Plodkowski, G J Riely, M S Ginsberg
Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). A recent study identified a highly unusual pattern of metastatic spread to axLN in patients with BRAF mutated colorectal cancer (CRC). The purpose of the study is to assess the incidence of axLN metastases in BRAF mutated NSCLC. Baseline computed tomography (CT) imaging at diagnosis and all follow up CTs of patients with BRAF mutated NSCLC treated at our institution were retrospectively reviewed by two radiologists for evidence of axLN metastases...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28625647/quantification-of-growth-patterns-of-screen-detected-lung-cancers-the-nelson-study
#11
Marjolein A Heuvelmans, Rozemarijn Vliegenthart, Harry J de Koning, Harry J M Groen, Michel J A M van Putten, Uraujh Yousaf-Khan, Carla Weenink, Kristiaan Nackaerts, Pim A de Jong, Matthijs Oudkerk
OBJECTIVES: Although exponential growth is assumed for lung cancer, this has never been quantified in vivo. Aim of this study was to evaluate and quantify growth patterns of lung cancers detected in the Dutch-Belgian low-dose computed tomography (CT) lung cancer screening trial (NELSON), in order to elucidate the development and progression of early lung cancer. MATERIALS AND METHODS: Solid lung nodules found at ≥3 CT examinations before lung cancer diagnosis were included...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28625151/na-k-atpase-as-a-target-for-treatment-of-tissue-fibrosis
#12
Sergei N Orlov, Jenifer La, Larisa V Smolyaninova, Nickolai O Dulin
Myofibroblast activation is a critical process in the pathogenesis of tissue fibrosis accounting for 45% of all deaths. No effective therapies are available for the treatment of fibrotic diseases. We focus our mini-review on recent data showing that cardiotonic steroids (CTS) that are known as potent inhibitors of Na+,K+-ATPase affect myofibroblast differentiation in a cell type-specific manner. In cultured human lung fibroblasts (HLF), epithelial cells, and cancer-associated fibroblasts, CTS blocked myofibroblast differentiation triggered by profibrotic cytokine TGF-β...
June 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28624065/trends-in-open-and-endoscopic-carpal-tunnel-release-utilization-in-the-medicare-patient-population
#13
Tsun Yee Law, Samuel Rosas, Zachary S Hubbard, Lee Onn Chieng, Harvey W Chim
BACKGROUND: Surgical management of carpal tunnel syndrome (CTS) is performed with an open or endoscopic approach. Current literature suggests that the endoscopic approach is associated with higher costs and a steeper learning curve. This study evaluated the billing and utilization trends of both approaches. METHODS: A retrospective review of a Medicare database within the PearlDiver Supercomputer (Warsaw, IN) was performed for patients undergoing open carpal tunnel release (OCTR) or endoscopic carpal tunnel release (ECTR) from 2005-2012...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28623065/upper-limb-neurodynamic-test-1-in-patients-with-clinical-diagnosis-of-carpal-tunnel-syndrome-a-diagnostic-accuracy-study
#14
Maria-Constanza Trillos, Felipe Soto, Leonardo Briceno-Ayala
STUDY DESIGN: Diagnostic accuracy. INTRODUCTION: Upper limb neurodynamic test 1 (ULNT1) is used to evaluate the mechanical sensitivity especially in the peripheral nerves of the upper limbs. The reproduction of typical symptoms in the affected hand improves the estimation of the probability of carpal tunnel syndrome (CTS). However the test has not been evaluated sufficiently to determine its real usefulness. In the present study the diagnostic accuracy of ULNT1 as a clinical test for CTS was determined...
June 13, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28619997/cardiotonic-steroids-stimulate-macrophage-inflammatory-responses-through-a-pathway-involving-cd36-tlr4-and-na-k-atpase
#15
Yiliang Chen, Wenxin Huang, Moua Yang, Gang Xin, Weiguo Cui, Zijian Xie, Roy L Silverstein
OBJECTIVE: Circulating levels of cardiotonic steroids (CTS) are elevated in various chronic inflammatory conditions, but the role of CTS in inflammation remains largely unknown. We have previously shown that the CTS ouabain stimulates proinflammatory responses in murine macrophages. In this study, we aim to explore the mechanism how CTS induce proinflammatory responses in primary murine and human macrophages. APPROACH AND RESULTS: Using both murine peritoneal macrophages and human monocyte-derived macrophages, we demonstrated that ouabain activated NF-κB, leading to proinflammatory cytokine (eg, MCP-1, tumor necrosis factor-α, interleukin-1β, and interleukin-6) production...
June 15, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28613165/lossless-compression-of-medical-images-using-3d-predictors
#16
Luis Lucas, Nuno Rodrigues, Luis Cruz, Sergio Faria
This paper describes a highly efficient method for lossless compression of volumetric sets of medical images, such as CTs or MRIs. The proposed method, referred to as 3D-MRP, is based on the principle of minimum rate predictors (MRP), which is one of the state-of-the-art lossless compression technologies, presented in the data compression literature. The main features of the proposed method include the use of 3D predictors, 3D-block octree partitioning and classification, volume-based optimisation and support for 16 bit-depth images...
June 9, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28612477/preliminary-experience-on-the-use-of-pet-ct-in-the-management-of-pediatric-post-transplant-lymphoproliferative-disorder
#17
Pilar Guerra-García, Steffen Hirsch, Daniel S Levine, Mary M Taj
INTRODUCTION: Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication following prolonged immunosuppression. Contrary to other lymphomas, there is no standardized imaging approach to assess PTLD either at staging or for response to therapy. Positron emission tomography/computed tomography (PET/CT) is an imaging modality that has proven to be useful in lymphoma. However, there is still limited data concerning its use in pediatric PTLD. Our study evaluates the use of PET/CT in pediatric PTLD at our institution...
June 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28612197/the-value-of-multimodality-imaging-in-the-investigation-of-a-psa-recurrence-after-radical-prostatectomy-in-the-irish-hospital-setting
#18
L C McLoughlin, S Inder, D Moran, C O'Rourke, R P Manecksha, T H Lynch
INTRODUCTION: The diagnostic evaluation of a PSA recurrence after RP in the Irish hospital setting involves multimodality imaging with MRI, CT, and bone scanning, despite the low diagnostic yield from imaging at low PSA levels. We aim to investigate the value of multimodality imaging in PC patients after RP with a PSA recurrence. METHODS: Forty-eight patients with a PSA recurrence after RP who underwent multimodality imaging were evaluated. Demographic data, postoperative PSA levels, and imaging studies performed at those levels were evaluated...
June 13, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28612038/resection-planning-for-robotic-acoustic-neuroma-surgery
#19
Kepra L McBrayer, George B Wanna, Benoit M Dawant, Ramya Balachandran, Robert F Labadie, Jack H Noble
Acoustic neuroma surgery is a procedure in which a benign mass is removed from the internal auditory canal (IAC). Currently, this surgical procedure requires manual drilling of the temporal bone followed by exposure and removal of the acoustic neuroma. This procedure is physically and mentally taxing to the surgeon. Our group is working on the development of an acoustic neuroma surgery robot (ANSR) to perform the initial drilling procedure. Planning the ANSR's drilling region using preoperative CT requires expertise and takes about 35 min...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28611320/prevalence-of-low-back-pain-and-carpal-tunnel-syndrome-among-dental-practitioners-in-dakshina-kannada-and-coorg-district
#20
D Anupama Prasad, Drithi Appachu, Vinayak Kamath, D Krishna Prasad
CONTEXT: Dental practitioners who usually have to work for long durations in a particular fixed posture are more prone to musculoskeletal disorders (MSDs), particularly those involving the hand and wrist and also of the lower back. AIMS: To study the prevalence of carpal tunnel syndrome (CTS) and low back pain (LBP) among dental practitioners and to correlate the symptoms with the duration of practice. SUBJECTS AND METHODS: A closed-end questionnaire was distributed to 100 dental practitioners from Dakshina Kannada and Coorg districts of Karnataka, India...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
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