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Intravenous iron

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https://www.readbyqxmd.com/read/29345426/single-dose-intravenous-iron-in-southeast-asian-heart-failure-patients-a-pilot-randomized-placebo-controlled-study-practice-asia-hf
#1
Tee Joo Yeo, Poh Shuan Daniel Yeo, Farid Abdul Hadi, Timothy Cushway, Kim Yee Lee, Fang Fang Yin, Anne Ching, Ruili Li, Seet Yoong Loh, Shir Lynn Lim, Raymond Ching-Chiew Wong, Bee Choo Tai, Arthur Mark Richards, Carolyn S P Lam
AIMS: Iron deficiency is highly prevalent in Southeast Asians with heart failure (HF) and associated with worse outcomes. This trial aimed to assess the effect of intravenous iron in Southeast Asians hospitalized with decompensated HF. METHODS AND RESULTS: Fifty patients hospitalized for acute decompensated HF, regardless of ejection fraction, with iron deficiency (defined as serum ferritin <300 ng/mL if transferrin saturation is <20%) were randomized to receive either one dose of intravenous ferric carboxymaltose (FCM) 1000 mg or placebo (0...
January 18, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29342861/rational-management-of-iron-deficiency-anaemia-in-inflammatory-bowel-disease
#2
REVIEW
Ole Haagen Nielsen, Christoffer Soendergaard, Malene Elbaek Vikner, Günter Weiss
Anaemia is the most frequent, though often neglected, comorbidity of inflammatory bowel disease (IBD). Here we want to briefly present (1) the burden of anaemia in IBD, (2) its pathophysiology, which mostly arises from bleeding-associated iron deficiency, followed by (3) diagnostic evaluation of anaemia, (4) a balanced overview of the different modes of iron replacement therapy, (5) evidence for their therapeutic efficacy and subsequently, (6) an updated recommendation for the practical management of anaemia in IBD...
January 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29338760/increased-plasmodium-chabaudi-malaria-mortality-in-mice-with-nutritional-iron-deficiency-can-be-reduced-by-short-term-adjunctive-iron-supplementation
#3
Filip C Castberg, Lasse Maretty, Trine Staalsoe, Casper Hempel, Erik Clasen-Linde, Lars Hviid, Jørgen A L Kurtzhals
BACKGROUND: Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. This has rendered interventions against iron deficiency in malaria-endemic areas controversial. METHODS: The effect of nutritional iron deficiency on the clinical outcome of Plasmodium chabaudi AS infection in A/J mice and the impact of intravenous iron supplementation with ferric carboxymaltose were studied before and after parasite infection...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29336240/treatment-of-anemia-in-patients-with-solid-tumors-receiving-chemotherapy-in-palliative-setting-usual-practice-versus-guidelines
#4
Robin de Putter, Karen Geboes, Marc De Man, Simon Van Belle
Background Anemia is frequent in patients with cancer and is often multifactorial. Treatment depends on etiology and can consist of transfusions, intravenous iron (IV Fe), and/or erythropoiesis-stimulating agents (ESA). Several studies have shown that cancer-related anemia is undertreated. The aim of this study is to compare usual practice in a university hospital with the international guidelines. Methods Using the hospital and pharmacy informatics all adults (≥18 years), who received a treatment for anemia (transfusion, IV Fe, ESA) from February to August 2016 during palliative chemotherapy, were identified...
January 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29329501/sustained-plasma-hepcidin-suppression-and-iron-elevation-by-anticalin-derived-hepcidin-antagonist-in-cynomolgus-monkey
#5
Andreas M Hohlbaum, Hendrik Gille, Stefan Trentmann, Maria Kolodziejczyk, Barbara Rattenstetter, Coby M Laarakkers, Galina Katzmann, Hans Jürgen Christian, Nicole Andersen, Andrea Allersdorfer, Shane A Olwill, Bernd Meibohm, Laurent P Audoly, Dorine W Swinkels, Rachel P L van Swelm
BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here we report the engineering of the human lipocalin-derived, small protein-based Anticalin PRS-080 hepcidin antagonist with high affinity and selectivity. EXPERIMENTAL APPROACH: Anticalin- and hepcidin-specific pharmacokinetic/pharmacodynamic modelling was used to design and select the suitable drug candidate based on half life extension and duration of hepcidin suppression...
January 12, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29329151/gadolinium-retention-brain-t1-hyperintensity-and-endogenous-metals-a-comparative-study-of-macrocyclic-versus-linear-gadolinium-chelates-in-renally-sensitized-rats
#6
Marlène Rasschaert, Andréa Emerit, Nathalie Fretellier, Cécile Factor, Philippe Robert, Jean-Marc Idée, Claire Corot
OBJECTIVES: This preclinical study was designed to compare gadolinium (Gd) brain uptake after repeated injections of a macrocyclic Gd-based contrast agent (GBCA) (gadoterate meglumine) or 2 linear GBCAs (L-GBCAs) (gadobenate dimeglumine or gadodiamide) on a translational model of moderate renal impairment in rats. METHODS: The study was carried out in subtotally nephrectomized rats. Animals received 4 intravenous injections per week of GBCA (gadoterate meglumine, gadobenate dimeglumine, or gadodiamide) for 5 weeks, resulting in a cumulative dose of 12 mmol/kg, followed by a 1-month injection-free period...
January 12, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29317052/iron-therapy-as-treatment-of-anemia-a-potentially-detrimental-and-hazardous-strategy-in-colorectal-cancer-patients
#7
M J Wilson, J J Harlaar, J Jeekel, M Schipperus, J J Zwaginga
In colorectal cancer patients, iron therapy, and especially intravenous iron therapy, is increasingly used to treat anemia and reduce the use of blood transfusions. However, iron has also been shown to be an essential nutrient for rapidly proliferating tissues and cells. In this respect, anemia of inflammation, characterized by limited duodenal iron uptake and sequestration of iron into the reticuloendothelial system, might be regarded as a potentially effective defense strategy of the human body against tumor growth...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29304848/effectiveness-and-safety-of-ferric-carboxymaltose-compared-to-iron-sucrose-in-women-with-iron-deficiency-anemia-phase-iv-clinical-trials
#8
Amreen Naqash, Rifat Ara, Ghulam N Bader
BACKGROUND: Iron deficiency anemia (IDA) is a significant problem worldwide particularly in women. The aim of the study was to evaluate the effectiveness and safety of intravenous ferric carboxymaltose (FCM) in comparison to iron sucrose (IS) in women with IDA. METHOD: Two hundred patients at Department of Obstetrics and Gynaecology, Sher-i-Kashmir Institute of Medical Sciences Medical College and Hospital, Jammu & Kashmir, India identified with IDA were enrolled for the study...
January 5, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29304320/intravenous-iron-out-of-sight-out-of-mind
#9
Michael Auerbach, Manuel Muñoz, Iain C Macdougall
No abstract text is available yet for this article.
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29303999/comparative-evaluation-of-u-s-brand-and-generic-intravenous-sodium-ferric-gluconate-complex-in-sucrose-injection-physicochemical-characterization
#10
Dajun Sun, Rodney Rouse, Vikram Patel, Yong Wu, Jiwen Zheng, Alokita Karmakar, Anil K Patri, Priyanka Chitranshi, David Keire, Jia Ma, Wenlei Jiang
The objective of this study was to evaluate physicochemical equivalence between brand (i.e., Ferrlecit) and generic sodium ferric gluconate (SFG) in sucrose injection by conducting a series of comparative in vitro characterizations using advanced analytical techniques. The elemental iron and carbon content, thermal properties, viscosity, particle size, zeta potential, sedimentation coefficient, and molecular weight were determined. There was no noticeable difference between brand and generic SFG in sucrose injection for the above physical parameters evaluated, except for the sedimentation coefficient determined by sedimentation velocity analytical ultracentrifugation (SV-AUC) and molecular weight by asymmetric field flow fractionation-multi-angle light scattering (AFFF-MALS)...
January 5, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29303906/the-efficacy-of-pre-operative-preparation-with-intravenous-iron-and-or-erythropoietin-in-anaemic-patients-undergoing-orthopaedic-surgery-an-observational-study
#11
Martina Heschl, Hans Gombotz, Bettina Haslinger-Eisterer, Axel Hofmann, Nikolaus Böhler, Jens Meier
BACKGROUND: Pre-operative anaemia and transfusion are common among patients undergoing elective orthopaedic surgery. Application of 'patient blood management' might be the most effective way to reduce both anaemia and transfusion. Pre-operative administration of iron and/or erythropoietin (EPO) is one of the cornerstones of the first pillar of patient blood management, but in a daily clinical setting, efficacy and long-term safety of this measure have not been analysed thoroughly to date...
January 4, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29300713/the-important-role-for-intravenous-iron-in-perioperative-patient-blood-management-in-major-abdominal-surgery-a-randomized-controlled-trial
#12
Bernd Froessler, Peter Palm, Ingo Weber, Nicolette A Hodyl, Rajvinder Singh, Elizabeth M Murphy
No abstract text is available yet for this article.
February 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29298794/severe-fgf23-based-hypophosphataemic-osteomalacia-due-to-ferric-carboxymaltose-administration
#13
Klara Klein, Shonda Asaad, Michael Econs, Janet E Rubin
Ferric carboxymaltose (FCM) is a novel iron formulation increasingly prescribed due to its effectiveness and fast infusion time. FCM administration can cause an asymptomatic hypophosphataemia secondary to fibroblast growth factor 23 (FGF23) dysregulation. In patients with chronic iron needs, however, a severe, long-lasting hypophosphataemia can lead to osteomalacia with associated bone pain. Lack of awareness of this complication results in delayed time to diagnosis and significant morbidity. We report a case of a patient with Crohn's disease and chronic iron-deficiency anaemia receiving multiple doses of FCM who developed severe hypophosphataemic osteomalacia with urinary phosphate loss and increased FGF23...
January 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29298488/engineered-cellular-uptake-and-controlled-drug-delivery-using-two-dimensional-nanoparticle-and-polymer-for-cancer-treatment
#14
Sudipta Senapati, Rashmi Shukla, Arun Kumar Mahanta, Dipak Rana, Pralay Maiti, Yamini B Tripathi
Two major problems in chemotherapy, poor bioavailability of hydrophobic anti-cancer drug and its adverse side effects causing nausea, are taken into accounts by developing sustained drug release vehicle along with enhanced bioavailability using two-dimensional layered double hydroxides (LDHs) with appropriate surface charge and its subsequent embedment in polymer matrix. A model hydrophobic anti-cancer drug, raloxifene hydrochloride (RH), is intercalated into a series of zinc iron LDHs with varying anion charge densities using ion exchange technique...
January 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29298480/evaluation-of-the-active-targeting-of-melanin-granules-after-intravenous-injection-of-dendronized-nanoparticles
#15
Catalina Bordeianu, Audrey Parat, Sébastien Piant, Aurélie Walter, Christine Zbaraszczuk-Affolter, Florent Meyer, Sylvie Begin-Colin, Sébastien Boutry, Robert N Muller, Elodie Jouberton, Jean-Michel Chezal, Bruno Labeille, Elisa Cinotti, Jean-Luc Perrot, Elisabeth Miot-Noirault, Sophie Laurent, Delphine Felder-Flesch
The biodistribution of dendronized iron oxides, NPs10@D1_DOTAGA and melanin-targeting NPs10@D1_ICF_DOTAGA, was studied in vivo using MRI and planar scintigraphy through [177Lu]Lu-radiolabeling. MRI experiments showed high contrast power of both dendronized nanoparticles (DPs) and hepatobiliary and urinary excretions. Little tumor uptake could be highlighted after intravenous injection probably as a consequence of the negatively charged DOTAGA-derivatized shell which reduces the diffusion across the cells' membrane...
January 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29298040/functionalization-and-characterization-of-magnetic-nanoparticles-for-the-detection-of-ferritin-accumulation-in-alzheimer-s-disease
#16
Tamara Fernández, Alberto Martínez-Serrano, Lorena Cussó, Manuel Desco, Milagros Ramos-Gómez
Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that leads to dementia and death. Therefore, there is an urgent need to generate new contrast agents which reveal by a non-invasive method the presence of some of the pathological signs of AD. In the present study we demonstrate for the first time a new nanoconjugate composed of magnetic nanoparticles bound to an anti-ferritin antibody, which has been developed based on the existence of iron deposits and high levels of the ferritin protein present in areas with a high accumulation of amyloid plaques (particularly the subiculum in the hippocampal area) in the brain of a transgenic mouse model with five familial AD mutations...
January 3, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29283393/comparative-evaluation-of-u-s-brand-and-generic-intravenous-sodium-ferric-gluconate-complex-in-sucrose-injection-biodistribution-after-intravenous-dosing-in-rats
#17
Christopher R Beekman, Murali Matta, Christopher D Thomas, Adil Mohammad, Sharron Stewart, Lin Xu, Ashok Chockalingam, Katherine Shea, Dajun Sun, Wenlei Jiang, Vikram Patel, Rodney Rouse
Relative biodistribution of FDA-approved innovator and generic sodium ferric gluconate (SFG) drug products was investigated to identify differences in tissue distribution of iron after intravenous dosing to rats. Three equal cohorts of 42 male Sprague-Dawley rats were created with each cohort receiving one of three treatments: (1) the innovator SFG product dosed intravenously at a concentration of 40 mg/kg; (2) the generic SFG product dosed intravenously at a concentration of 40 mg/kg; (3) saline dosed intravenously at equivalent volume to SFG products...
December 28, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29282252/iron-modulation-of-erythropoiesis-is-associated-with-scribble-mediated-control-of-the-erythropoietin-receptor
#18
Shadi Khalil, Lorrie Delehanty, Stephen Grado, Maja Holy, Zollie White, Katie Freeman, Ryo Kurita, Yukio Nakamura, Grant Bullock, Adam Goldfarb
Iron-restricted human anemias are associated with the acquisition of marrow resistance to the hematopoietic cytokine erythropoietin (Epo). Regulation of Epo responsiveness by iron availability serves as the basis for intravenous iron therapy in anemias of chronic disease. Epo engagement of its receptor normally promotes survival, proliferation, and differentiation of erythroid progenitors. However, Epo resistance caused by iron restriction selectively impairs proliferation and differentiation while preserving viability...
December 27, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29280914/anemia-and-coronary-artery-disease-pathophysiology-prognosis-and-treatment
#19
Jennifer A Rymer, Sunil V Rao
The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state persists chronically. We will examine the evidence for anemia as an independent risk factor for CAD events and cardiovascular mortality after percutaneous coronary intervention. We will also investigate the thresholds for appropriate blood transfusion in patients with CAD, as well as the cardiovascular outcomes associated with the utilization of a liberal versus conservative blood transfusion strategy...
December 26, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29278742/evaluation-of-the-suitability-of-a-sprague-dawley-rat-model-to-assess-intravenous-iron-preparations
#20
Kimberley Span, Ebel H E Pieters, Vera Brinks, Wim E Hennink, Huub Schellekens
The aim of the study was to examine the reproducibility of a rat model to assess the preclinical similarity in safety profiles and tissue accumulation of iron products. Accordingly, the effect of several doses of intravenously administered Venofer® and of Ferrlecit® on blood parameters, and on kidney and particularly liver toxicity were examined in non-anemic Sprague Dawley rats. The different analysis showed neither a clear treatment nor a dose effect after multiple injections. The parameters measured in this rat strain showed some iron induced adverse effects, but these could not be correlated to treatment specific differences...
December 23, 2017: Journal of Pharmacological and Toxicological Methods
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