Read by QxMD icon Read


Rebecca Krochmal, Chakravarthy Reddy, Lonny Yarmus, Neeraj R Desai, David Feller-Kopman, Hans J Lee
BACKGROUND: Malignant pleural effusions (MPEs) represent advanced stage disease with potentially significant patient discomfort due to dyspnea. Palliative management options include repetitive thoracenteses, placement of a tunneled pleural catheter (TPC), chemical pleurodesis, or some combination of these procedures. The rapid pleurodesis procedure combines thoracoscopic talc pleurodesis and insertion of a TPC at the same time with the goals of reducing both the length of hospitalization and the duration of catheter use...
September 2016: Journal of Thoracic Disease
Yoshihiro Hayashi, Sohta Akiyama, Akimitsu Miyaji, Yasumasa Sekiguchi, Yasuharu Sakamoto, Akinobu Shiga, To-Ru Koyama, Ken Motokura, Toshihide Baba
The one-step conversion of ethanol to 1,3-butadiene was performed using talc containing Zn (talc/Zn) as a catalyst. The influence of the MgO and Zn in the talc on the formation rate and selectivity for 1,3-butadiene were investigated. MgO as a catalyst afforded 1,3-butadiene with a selectivity that was nearly the same as talc/Zn at ∼40% ethanol conversion at 673 K, although the rate of 1,3-butadiene formation over MgO was about 40 times lower than that over the talc/Zn. The introduced Zn cations were located in octahedral sites in place of Mg cations in the talc lattice...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Jeffrey H Mandel, Bruce H Alexander, Gurumurthy Ramachandran
BACKGROUND: Mining of gold, taconite, and talc may involve exposure to elongate mineral particles (EMP). The involved EMPs are typically non-asbestiform, include dimensions that regulatory definitions exclude, and have been less studied. METHODS: A review of the literature was undertaken for this exposure and occupational epidemiological studies that occur in gold, talc, and taconite mining. RESULTS: Quantitative EMP exposure information in these industries is incomplete...
October 4, 2016: American Journal of Industrial Medicine
Muzna Sadia, Agata Sośnicka, Basel Arafat, Abdullah Isreb, Waqar Ahmed, Antonios Kelarakis, Mohamed A Alhnan
This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with several model drugs. It investigates the addition of non-melting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of (i) the nature of filler, (ii) compatibility with the gears of the 3D printer and iii) polymer: filler ratio on the 3D printing process. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135°C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet...
September 15, 2016: International Journal of Pharmaceutics
Michal M Urbanczyk, Ulla E Bollmann, Kai Bester
The use of biocides as additives for building materials has gained importance in the recent years. These biocides are applied, e.g., to renders and paints to prevent them from microbial spoilage. However, these biocides can leach out into the environment. In order to better understand this leaching, the partition of biocides between water and inorganic phases of render with organic binder was investigated. The partition constants of carbendazim, diuron, iodocarb, isoproturon, cybutryn (irgarol), octylisothiazolinone, terbutryn, and tebuconazole towards minerals typically used in renders, e...
August 29, 2016: Science of the Total Environment
Oliver J Bintcliffe, Gary Y C Lee, Najib M Rahman, Nick A Maskell
The evidence base concerning the management of benign pleural effusions has lagged behind that of malignant pleural effusions in which recent randomised trials are now informing current clinical practice and international guidelines.The causes of benign pleural effusions are broad, heterogenous and patients may benefit from individualised management targeted at both treating the underlying disease process and direct management of the fluid. Pleural effusions are very common in a number of non-malignant pathologies, such as decompensated heart failure, and following coronary artery bypass grafting...
September 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
Kango Nohara, Kazuto Takada, Eiji Kojima, Kiyoko Ninomiya, Shoko Miyamatsu, Takahiro Shimizu, Tsutomu Sakurai, Takaaki Mizuno, Yuuki Yamashita
BACKGROUND: The choice of an optimal sclerosant for pleurodesis for malignant pleural effusion remains controversial. This retrospective clinical study compared the efficacy and safety of two sclerosants; talc slurry (talc-s) and OK-432. METHODS: We compared the characteristics, 30/90-day success rates, and adverse events in patients with lung adenocarcinoma who underwent pleurodesis by using either OK-432 or talc-s. Propensity score matching was used to compare the two scelrosants...
September 2016: Respiratory Investigation
Ken-Ichi Hirauchi, Kumi Fukushima, Masanori Kido, Jun Muto, Atsushi Okamoto
Earth is the only terrestrial planet in our solar system where an oceanic plate subducts beneath an overriding plate. Although the initiation of plate subduction requires extremely weak boundaries between strong plates, the way in which oceanic mantle rheologically weakens remains unknown. Here we show that shear-enhanced hydration reactions contribute to the generation and maintenance of weak mantle shear zones at mid-lithospheric depths. High-pressure friction experiments on peridotite gouge reveal that in the presence of hydrothermal water, increasing strain and reactions lead to an order-of-magnitude reduction in strength...
2016: Nature Communications
Erika T Chow, Shruthi Mahalingaiah
Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact: parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredients in the best-selling and top-rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by nonprofit environmental organizations, reveals 11 chemicals and chemical families of concern: butylated hydroxyanisole/butylated hydroxytoluene, coal tar dyes, diethanolamine, formaldehyde-releasing preservatives, parabens, phthalates, 1,4-dioxane, polycyclic aromatic hydrocarbons, siloxanes, talc/asbestos, and triclosan...
September 15, 2016: Fertility and Sterility
Servane Blanvillain-Baufumé, Maik Reschke, Montserrat Solé, Florence Auguy, Hinda Doucoure, Boris Szurek, Donaldo Meynard, Murielle Portefaix, Sébastien Cunnac, Emmanuel Guiderdoni, Jens Boch, Ralf Koebnik
As a key virulence strategy to cause Bacterial Leaf Blight, Xanthomonas oryzae pv. oryzae (Xoo) injects into the plant cell DNA-binding proteins called Transcription Activator-Like Effectors (TALEs), that bind to Effector-Binding Elements (EBEs) in a sequence-specific manner, resulting in host gene induction. TALEs AvrXa7, PthXo3, TalC and Tal5, found in geographically distant Xoo strains, all target OsSWEET14, thus considered as a pivotal TALE target acting as major susceptibility factor during rice-Xoo interactions...
August 19, 2016: Plant Biotechnology Journal
Tochukwu C Okwuosa, Dominika Stefaniak, Basel Arafat, Abdullah Isreb, Ka-Wai Wan, Mohamed A Alhnan
PURPOSE: The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing. METHODS: Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME)...
November 2016: Pharmaceutical Research
Elena Tamburini, Chiara Tagliati, Tiziano Bonato, Stefania Costa, Chiara Scapoli, Paola Pedrini
Near-infrared spectroscopy (NIRS) has been widely used for quantitative and/or qualitative determination of a wide range of matrices. The objective of this study was to develop a NIRS method for the quantitative determination of fluorine content in polylactide (PLA)-talc blends. A blending profile was obtained by mixing different amounts of PLA granules and talc powder. The calibration model was built correlating wet chemical data (alkali digestion method) and NIR spectra. Using FT (Fourier Transform)-NIR technique, a Partial Least Squares (PLS) regression model was set-up, in a concentration interval of 0 ppm of pure PLA to 800 ppm of pure talc...
2016: Sensors
Joanna Brown, Jason Rafferty, Deborah Golding, Victoria Adewale, Lauren Chan, Christina Pastorello, Patricia Stebbins, Jodie Neukirch
Health reform strives to be patient-centered but often emphasizes institutional and financial well-being at the expense of patient responsiveness. Rhode Island is a pioneer, with innovative youth engagement programs in health care. The Youth Advisory Board of the Adolescent Patient-Centered Medical Home (PCMH) Initiative at Brown Family Medicine has brought together adolescents to gather feedback about participants' preferences for their health care and bring that feedback to health care providers. The Adolescent Leadership Council (TALC) of Hasbro Children's Hospital is comprised of adolescents with chronic medical illnesses and serves as an advisory group...
2016: Rhode Island Medical Journal
Yuli Wang, Meiyan Yang, Ruifang Shen, Shuai Shao, Lu Chen, Wei Gong, Li Shan, Chunsheng Gao
Talc is one of the most commonly used antiadherents in the coating film. However, the mechanism of influence of talc on drug release has yet to be fully understood. In this study, metoprolol tartrate (MT)-loaded Eudragit NE 30 D-coated sustained-release (SR) pellets were prepared using talc as an antiadherent in the layering and coating processes. Talc significantly reduced the stickiness of the layered or coated substrates, thus enhancing the process smoothness. Moreover, the incorporation of talc into the coating film significantly affected drug release...
July 28, 2016: Pharmaceutical Development and Technology
Thanh-Phuong Nguyen, Sowmya Nanjappa, Manjunath Muddaraju, John N Greene
The first case of pulmonary talcosis or talc pneumoconiosis related to inhalation of talc during its extraction and processing in mines was described by Thorel in 1896. Pulmonary talcosis is most commonly seen secondary to occupational exposure or intravenous (IV) drug abuse and, occasionally, in excessive use of cosmetic talc. Based on literature review, there has been an increase in reported incidents of pulmonary talcosis due to various forms of exposure to the mineral. We report an 82-year-old man who is diagnosed with Philadelphia chromosome positive pre-B cell acute lymphoblastic leukemia (ALL) treated with palliative imatinib who presented with chronic hemoptysis and dyspnea shortly after his diagnosis...
2016: Case Reports in Medicine
Susan Walker, Marijana Zubrinic, Christine Massey, Yaron Shargall, Eric Bédard, Gail Darling
BACKGROUND: In a patient population with a limited life expectancy, malignant pleural effusion can significantly impact quality of life (QoL). Different treatment options are available, each with its own effect on QoL. To date, satisfaction with treatment options has not been evaluated. PURPOSE: To evaluate QoL and satisfaction with treatment using patient-reported outcomes for four different treatment strategies. DESIGN: A prospective, cohort study that compared four treatment options: indwelling pleural catheter (IPC); video assisted thoracic surgery (VATS) and IPC; chest tube and talc slurry; and VATS talc poudrage...
July 2, 2016: International Journal of Palliative Nursing
Giuseppe Cardillo, Oliver J Bintcliffe, Francesco Carleo, Luigi Carbone, Marco Di Martino, Brennan C Kahan, Nick A Maskell
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is an increasingly common treatment for recurrent or persistent primary spontaneous pneumothorax (PSP). Surgery usually involves diffuse treatment of the pleura and possible targeted therapy to areas of bullous disease. The purpose of this large cohort study was to examine incidence of recurrence after VATS and identify predictors of outcome. METHODS: Patients undergoing VATS for PSP at a single centre between 2000 and 2012 were prospectively enrolled...
September 2016: Thorax
Shimaa Nour Moursi Ahmed, Hideo Saka, Hamdy Ali Mohammadien, Ola Alkady, Masahide Oki, Yoshimasa Tanikawa, Rie Tsuboi, Masahiro Aoyama, Keiji Sugiyama
Objectives. To highlight the possible complications of medical thoracoscopy (MT) and how to avoid them. Methods. A retrospective and prospective analysis of 127 patients undergoing MT in Nagoya Medical Center (NMC) and Toyota Kosei Hospital. The data about complications was obtained from the patients, notes on the computer system, and radiographs. Results. The median age was 71.0 (range, 33.0-92.0) years and 101 (79.5%) were males. The median time with chest drain after procedure was 7.0 (range, 0.0-47.0) days and cases with talc poudrage were 30 (23...
2016: Advances in Medicine
Shannon H Gaffney, Matthew Grespin, Lindsey Garnick, Derek A Drechsel, Rebecca Hazan, Dennis J Paustenbach, Brooke D Simmons
Anthophyllite is an amphibole form of asbestos historically used in only a limited number of products. No published resource currently exists that offers a complete overview of anthophyllite toxicity or of its effects on exposed human populations. We performed a review focusing on how anthophyllite toxicity was understood over time by conducting a comprehensive search of publicly available documents that discussed the use, mining, properties, toxicity, exposure and potential health effects of anthophyllite...
July 11, 2016: Journal of Applied Toxicology: JAT
Elizabeth L Anderson, Patrick J Sheehan, Renee M Kalmes, John R Griffin
This study's objective is to assess the risk of asbestos-related disease being contracted by past users of cosmetic talcum powder.  To our knowledge, no risk assessment studies using exposure data from historical exposures or chamber simulations have been published. We conducted activity-based sampling with cosmetic talcum powder samples from five opened and previously used containers that are believed to have been first manufactured and sold in the 1960s and 1970s.  These samples had been subject to conflicting claims of asbestos content; samples with the highest claimed asbestos content were tested...
July 9, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"