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https://www.readbyqxmd.com/read/27905700/use-of-ozone-depleting-substances-direct-final-rule
#1
(no author information available yet)
The Food and Drug Administration (FDA, the Agency, or we) is amending its regulation on uses of ozone-depleting substances (ODSs), including chlorofluorocarbons (CFCs), to remove the designation for certain products as "essential uses" under the Clean Air Act. Essential-use products are exempt from the ban by FDA on the use of CFCs and other ODS propellants in FDA-regulated products and from the ban by the Environmental Protection Agency (EPA) on the use of ODSs in pressurized dispensers. The products that will no longer constitute an essential use are: Sterile aerosol talc administered intrapleurally by thoracoscopy for human use and metered-dose atropine sulfate aerosol human drugs administered by oral inhalation...
October 26, 2016: Federal Register
https://www.readbyqxmd.com/read/27894987/a-novel-approach-for-dry-powder-coating-of-pellets-with-ethylcellulose-part-i-evaluation-of-film-formulation-and-process-set-up
#2
Beatrice Albertini, Serena Bertoni, Cecilia Melegari, Luisa Stella Dolci, Nadia Passerini
An innovative dry powder coating technology was developed in a high-shear granulator using ethylcellulose (E10) as polymer. Several solid plasticizers were investigated with the aim of decreasing the polymer Tg at least to the highest possible working temperature (80°C). DSC analysis of physical mixtures of E10 and plasticizers evidenced that lauric acid (LA) was the most effective plasticizer. In order to reach the target temperature a liquid plasticizer, oleic acid (OA), was introduced in the coating formulation...
November 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27872806/case-report-a-rare-case-of-eosinophilic-cholecystitis-presenting-after-talc-pleurodesis-for-recurrent-pneumothorax
#3
J Caesar, M Jordan, M Hills
Eosinophilic cholecystitis (EC) is a rare inflammatory condition of the gallbladder, confirmed by a cellular infiltrate comprised of more than 90% eosinophils in the gallbladder wall on histological examination. Although the etiology of EC is largely unknown, local autoimmune reactions within the gallbladder wall to inflammatory mediators from distal sites of inflammation have been hypothesized. Talc pleurodesis (TP) is a common clinical procedure used within respiratory medicine. However, it is associated with activation of systemic acute inflammatory responses including an increase in serum interleukin-8 (IL-8), which is a potent mediator of eosinophil chemotaxis...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27851565/1931-endobronchial-blocker-use-for-bpf-in-the-setting-of-ards-secondary-to-talc-pleurodesis
#4
Alberto Monegro, Andy Parker
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27804104/bacillus-subtilis-based-formulation-for-the-control-of-postbloom-fruit-drop-of-citrus
#5
Mariana Nadjara Klein, Aline Caroline da Silva, Katia Cristina Kupper
Postbloom fruit drop (PFD) caused by Colletotrichum acutatum affects flowers and causes early fruit drop in all commercial varieties of citrus. Biological control with the isolate ACB-69 of Bacillus subtilis has been considered as a potential method for controlling this disease. This study aimed to develop and optimize a B. subtilis based-formulation with a potential for large-scale applications and evaluate its effect on C. acutatum in vitro and in vivo. Bacillus subtilis based-formulations were developed using different carrier materials, and their ability to control PFD was evaluated...
December 2016: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/27803156/effectiveness-of-chemical-pleurodesis-in-spontaneous-pneumothorax-recurrence-prevention-a-systematic-review
#6
R J Hallifax, A Yousuf, H E Jones, J P Corcoran, I Psallidas, N M Rahman
OBJECTIVES: Spontaneous pneumothorax is a common pathology. International guidelines suggest pleurodesis for non-resolving air leak or recurrence prevention at second occurrence. This study comprehensively reviews the existing literature regarding chemical pleurodesis efficacy. DESIGN: We systematically reviewed the literature to identify relevant randomised controlled trials (RCTs), case-control studies and case series. We described the findings of these studies and tabulated relative recurrence rates or ORs (in studies with control groups)...
November 1, 2016: Thorax
https://www.readbyqxmd.com/read/27800256/transpupillary-argon-laser-cyclophotocoagulation-in-a-refractory-traumatic-glaucoma-patient-with-aphakia-and-aniridia
#7
Umut Duygu Uzunel, Berna Yüce, Tuncay Küsbeci, Halil Ateş
We present a case of transpupillary argon laser cyclophotocoagulation (TALC) in a patient with traumatic aniridia and aphakia secondary to blunt trauma who had previous bilateral trabeculectomy. Four months after the trauma the patient's intraocular pressure (IOP) rose to 35 mmHg despite topical antiglaucomatous medication. Inferior 180 degrees cyclophotocoagulation was performed with transpupillary argon laser in the first session and his IOP fell to values of 12-17 mmHg. Twelve weeks after TALC, his IOP rose to 22 mmHg and we had to apply TALC to the residual ciliary processes...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27798020/optimum-a-protocol-for-a-multicentre-randomised-controlled-trial-comparing-out-patient-talc-slurry-via-indwelling-pleural-catheter-for-malignant-pleural-effusion-vs-usual-inpatient-management
#8
P Sivakumar, A Douiri, A West, D Rao, G Warwick, T Chen, L Ahmed
INTRODUCTION: The development of malignant pleural effusion (MPE) results in disabling breathlessness, pain and reduced physical capability with treatment a palliative strategy. Ambulatory management of MPE has the potential to improve quality of life (QoL). The OPTIMUM trial is designed to determine whether full outpatient management of MPE with an indwelling pleural catheter (IPC) and pleurodesis improves QoL compared with traditional inpatient care with a chest drain and talc pleurodesis...
October 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27789902/a-36-year-old-female-with-recurrent-left-sided-pleural-effusion-a-rare-case-of-mediastinal-lymphangioma
#9
Rajesh N Swarnakar, Jetendra D Hazarey, Chetan Dhoble, Bhavesh Vaghani, Alaine S Ainsley, James F Khargie, Lorena Likaj
BACKGROUND Lymphangioma is an atypical non-malignant, lymphatic lesion that is congenital in origin. Lymphangioma is most frequently observed in the head and neck, but can occur at any location in the body. About 65% of lymphangiomas are apparent at birth, while 80-90% are diagnosed by two years of age. Occurrence in adults is rare, as evidenced by less than 100 cases of adult lymphangiomas reported in the literature. CASE REPORT A 36-year-old Indian woman with a medical history of recurrent pleural effusions presented with chief complaints of dyspnea on exertion for one year and a low-grade fever for one month...
October 28, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27779992/survival-difference-in-patients-with-malignant-pleural-effusions-treated-with-pleural-catheter-or-talc-pleurodesis
#10
Douglas Z Liou, Derek Serna-Gallegos, Joshua L Chan, Jerald Borgella, Shah Akhmerov, Harmik J Soukiasian
Malignant pleural effusions (MPE) are commonly managed with either pleural catheter (PC) or talc pleurodesis (TP). The aim of this study was to compare survival in MPE patients treated with either PC or TP. A retrospective review of our cancer center database was performed. Patients with metastatic cancer and MPE were analyzed. Demographic and clinical data were tabulated and compared. A total of 238 patients with MPE treated by either PC or TP were included. Of these, 79 patients comprised the PC group and 159 the TP group...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27767408/a-case-of-acute-pericarditis-following-intravenous-injection-of-crushed-morphine-tablets
#11
Ryan J Anderson, Bryan Corbett, Binh T Ly
A 37-year-old male presented with sharp, severe chest pain following seven days of intravenous injection of crushed morphine tablets. The chest pain was positional and pleuritic in nature and resolved with leaning forward. Work-up was notable for an ECG with inferior and anterolateral PR depressions as well as a CT chest with diffuse centrilobular nodules. Per radiology, the CT findings along with the patient's history were concerning for pulmonary granulomatosis from deposition of talc or some other foreign body...
November 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27747006/patient-evaluation-for-rapid-pleurodesis-of-malignant-pleural-effusions
#12
Rebecca Krochmal, Chakravarthy Reddy, Lonny Yarmus, Neeraj R Desai, David Feller-Kopman, Hans J Lee
BACKGROUND: Malignant pleural effusions (MPEs) represent advanced stage disease with potentially significant patient discomfort due to dyspnea. Palliative management options include repetitive thoracenteses, placement of a tunneled pleural catheter (TPC), chemical pleurodesis, or some combination of these procedures. The rapid pleurodesis procedure combines thoracoscopic talc pleurodesis and insertion of a TPC at the same time with the goals of reducing both the length of hospitalization and the duration of catheter use...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27711446/experimental-and-computational-studies-of-the-roles-of-mgo-and-zn-in-talc-for-the-selective-formation-of-1-3-butadiene-in-the-conversion-of-ethanol
#13
Yoshihiro Hayashi, Sohta Akiyama, Akimitsu Miyaji, Yasumasa Sekiguchi, Yasuharu Sakamoto, Akinobu Shiga, To-Ru Koyama, Ken Motokura, Toshihide Baba
The one-step conversion of ethanol to 1,3-butadiene was performed using talc containing Zn (talc/Zn) as a catalyst. The influence of the MgO and Zn in the talc on the formation rate and selectivity for 1,3-butadiene were investigated. MgO as a catalyst afforded 1,3-butadiene with a selectivity that was nearly the same as talc/Zn at ∼40% ethanol conversion at 673 K, although the rate of 1,3-butadiene formation over MgO was about 40 times lower than that over the talc/Zn. The introduced Zn cations were located in octahedral sites in place of Mg cations in the talc lattice...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27699808/a-review-of-mortality-associated-with-elongate-mineral-particle-emp-exposure-in-occupational-epidemiology-studies-of-gold-talc-and-taconite-mining
#14
REVIEW
Jeffrey H Mandel, Bruce H Alexander, Gurumurthy Ramachandran
BACKGROUND: Mining of gold, taconite, and talc may involve exposure to elongate mineral particles (EMP). The involved EMPs are typically non-asbestiform, include dimensions that regulatory definitions exclude, and have been less studied. METHODS: A review of the literature was undertaken for this exposure and occupational epidemiological studies that occur in gold, talc, and taconite mining. RESULTS: Quantitative EMP exposure information in these industries is incomplete...
December 2016: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/27640246/adaptation-of-pharmaceutical-excipients-to-fdm-3d-printing-for-the-fabrication-of-patient-tailored-immediate-release-tablets
#15
Muzna Sadia, Agata Sośnicka, Basel Arafat, Abdullah Isreb, Waqar Ahmed, Antonios Kelarakis, Mohamed A Alhnan
This work aims to employ fused deposition modelling 3D printing to fabricate immediate release pharmaceutical tablets with several model drugs. It investigates the addition of non-melting filler to methacrylic matrix to facilitate FDM 3D printing and explore the impact of (i) the nature of filler, (ii) compatibility with the gears of the 3D printer and iii) polymer: filler ratio on the 3D printing process. Amongst the investigated fillers in this work, directly compressible lactose, spray-dried lactose and microcrystalline cellulose showed a level of degradation at 135°C whilst talc and TCP allowed consistent flow of the filament and a successful 3D printing of the tablet...
September 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27585432/partition-of-biocides-between-water-and-inorganic-phases-of-renders-with-organic-binder
#16
Michal M Urbanczyk, Ulla E Bollmann, Kai Bester
The use of biocides as additives for building materials has gained importance in the recent years. These biocides are applied, e.g., to renders and paints to prevent them from microbial spoilage. However, these biocides can leach out into the environment. In order to better understand this leaching, the partition of biocides between water and inorganic phases of render with organic binder was investigated. The partition constants of carbendazim, diuron, iodocarb, isoproturon, cybutryn (irgarol), octylisothiazolinone, terbutryn, and tebuconazole towards minerals typically used in renders, e...
December 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27581830/the-management-of-benign-non-infective-pleural-effusions
#17
Oliver J Bintcliffe, Gary Y C Lee, Najib M Rahman, Nick A Maskell
The evidence base concerning the management of benign pleural effusions has lagged behind that of malignant pleural effusions in which recent randomised trials are now informing current clinical practice and international guidelines.The causes of benign pleural effusions are broad, heterogenous and patients may benefit from individualised management targeted at both treating the underlying disease process and direct management of the fluid. Pleural effusions are very common in a number of non-malignant pathologies, such as decompensated heart failure, and following coronary artery bypass grafting...
September 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27566382/a-propensity-score-matched-comparison-of-the-efficacies-of-ok-432-and-talc-slurry-for-pleurodesis-for-malignant-pleural-effusion-induced-by-lung-adenocarcinoma
#18
Kango Nohara, Kazuto Takada, Eiji Kojima, Kiyoko Ninomiya, Shoko Miyamatsu, Takahiro Shimizu, Tsutomu Sakurai, Takaaki Mizuno, Yuuki Yamashita
BACKGROUND: The choice of an optimal sclerosant for pleurodesis for malignant pleural effusion remains controversial. This retrospective clinical study compared the efficacy and safety of two sclerosants; talc slurry (talc-s) and OK-432. METHODS: We compared the characteristics, 30/90-day success rates, and adverse events in patients with lung adenocarcinoma who underwent pleurodesis by using either OK-432 or talc-s. Propensity score matching was used to compare the two scelrosants...
September 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27562366/reaction-induced-rheological-weakening-enables-oceanic-plate-subduction
#19
Ken-Ichi Hirauchi, Kumi Fukushima, Masanori Kido, Jun Muto, Atsushi Okamoto
Earth is the only terrestrial planet in our solar system where an oceanic plate subducts beneath an overriding plate. Although the initiation of plate subduction requires extremely weak boundaries between strong plates, the way in which oceanic mantle rheologically weakens remains unknown. Here we show that shear-enhanced hydration reactions contribute to the generation and maintenance of weak mantle shear zones at mid-lithospheric depths. High-pressure friction experiments on peridotite gouge reveal that in the presence of hydrothermal water, increasing strain and reactions lead to an order-of-magnitude reduction in strength...
2016: Nature Communications
https://www.readbyqxmd.com/read/27545020/cosmetics-use-and-age-at-menopause-is-there-a-connection
#20
REVIEW
Erika T Chow, Shruthi Mahalingaiah
Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact: parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredients in the best-selling and top-rated products of the top beauty brands in the world, as well as a review of highlighted chemicals by nonprofit environmental organizations, reveals 11 chemicals and chemical families of concern: butylated hydroxyanisole/butylated hydroxytoluene, coal tar dyes, diethanolamine, formaldehyde-releasing preservatives, parabens, phthalates, 1,4-dioxane, polycyclic aromatic hydrocarbons, siloxanes, talc/asbestos, and triclosan...
September 15, 2016: Fertility and Sterility
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