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platelet and inflammation

A Straumfors, W Eduard, K K Heldal, M Skogstad, L Barregård, D G Ellingsen
PURPOSE: To investigate if blood biomarkers could indicate early signs of lung damage or cardiovascular risk due to exposure to grain dust. MATERIALS AND METHODS: Pneumoproteins and markers of inflammation and platelet activation were analyzed in blood samples of 102 grain elevator and compound feed mill workers. Differences between exposed (n = 67) and controls (n = 35), and associations with exposure measurements and respiratory health were investigated by multiple linear regression analyses...
June 18, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Juliet Reid, Stefano Zamuner, Ken Edwards, Sally-Anne Rumley, Katherine Nevin, Maria Feeney, Chiara Zecchin, Disala Fernando, Nicolas Wisniacki
BACKGROUND: The oncostatin M (OSM) pathway drives fibrosis, inflammation and vasculopathy and is a potential therapeutic target for inflammatory and fibrotic diseases. METHODS: This was a Phase I, randomised, double-blind, placebo-controlled, single-dose escalation, first-time-in-human study of subcutaneously administered GSK2330811, an anti-OSM monoclonal antibody, in healthy adults (NCT02386436). Safety and tolerability, GSK2330811 pharmacokinetic profile, OSM levels in blood and skin and potential for anti-drug antibody formation were assessed...
June 13, 2018: British Journal of Clinical Pharmacology
Oktay Aydin, Gökhan Karaca, Faruk Pehlivanli, Canan Altunkaya, Hafize Uzun, Hüseyin Özden, Gülçin Aydin, İbrahim Tayfun Şahiner, Mehmet Niyaz, Osman Güler
BACKGROUND: The present study investigated the effectiveness of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) in wound healing suppressed by corticosteroid in rats. METHODS: Forty rats were separated into four groups. To disrupt the wound-healing processes, intraperitoneal single dose 10 mg/kg methylprednisolone was administered to all rats with the exception of Sham-S group. Then, full-thickness incision was performed to the abdominal skin of all animals, and PRP or MSCs were applied to the incision line except the Sham-S and Sham-M group animals...
June 8, 2018: Journal of Clinical Medicine
Remigiusz Kazimierczyk, Karol Kamiński
Pulmonary arterial hypertension is a multifactorial disease characterized by vasoconstriction, vascular remodeling, inflammation and thrombosis. Although an increasing number of research confirmed that pulmonary artery endothelial cells, pulmonary artery smooth muscle cells as well as platelets have a role in the pulmonary arterial hypertension pathogenesis, it is still unclear what integrates these factors. In this paper, we review the evidence that platelets through releasing a large variety of chemokines could actively impact the pulmonary arterial hypertension pathogenesis and development...
June 6, 2018: Advances in Medical Sciences
Sabine Schröder, Dajana Juerß, Stephan Kriesen, Katrin Manda, Guido Hildebrandt
PURPOSE: The application of radiation therapy is not only used to treat cancer, in Germany it is also an accepted and empirically established treatment of patients with benign diseases at low doses. The immune modulatory response generated by low-dose radiation therapy has a supporting anti-inflammatory effect within the treatment of inflammation-related diseases. The aim of this study was to investigate the effect of ionizing radiation (IR) on the expression and secretion of inflammatory mediators by endothelial cells (EC) exposed to low and moderate doses...
June 8, 2018: International Journal of Radiation Biology
Taisiya Bezhaeva, Margreet R de Vries, Wouter J Geelhoed, Eric P van der Veer, Sabine Versteeg, Carla M A van Alem, Bram M Voorzaat, Niels Eijkelkamp, Koen E van der Bogt, Alexander I Agoulnik, Anton-Jan van Zonneveld, Paul H A Quax, Joris I Rotmans
The pathophysiology of arteriovenous fistula (AVF) maturation failure is not completely understood but impaired outward remodeling (OR) and intimal hyperplasia are thought to be contributors. This adverse vascular response after AVF surgery results from interplay between vascular smooth muscle cells (VSMCs), the extracellular matrix (ECM), and inflammatory cells. Relaxin (RLN) is a hormone that acts on the vasculature via interaction with RLN/insulin-like peptide family receptor 1 (RXFP1), resulting in vasodilatation, ECM remodeling, and decreased inflammation...
June 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
P A F Pacheco, L P Dantas, L G B Ferreira, Robson Xavier Faria
Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world...
June 7, 2018: Journal of Bioenergetics and Biomembranes
Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Kiran Radia, Alice Kanyua, Elizabeth Kagotho, Mariza Hoffman, Peter Ojwang, Zul Premji, Kiyoshi Ichihara, Rajiv Erasmus
BACKGROUND: There are racial, ethnic and geographical differences in complete blood count (CBC) reference intervals (RIs) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in Africa to derive CBC RIs but many were not conducted with the rigor recommended for RI studies hence limiting the adoption and generalizability of the results. METHOD: By use of a Beckman Coulter ACT 5 DIFF CP analyser, we measured CBC parameters in samples collected from 528 healthy black African volunteers in a largely urban population...
2018: PloS One
Brian R Branchford, Shannon L Carpenter
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT), and pulmonary embolism (PE), is becoming increasingly recognized as a cause of morbidity and mortality in pediatrics, particularly among hospitalized children. Furthermore, evidence is accumulating that suggests the inflammatory response may be a cause, as well as consequence, of VTE, but current anticoagulation treatment regimens are not designed to inhibit inflammation. In fact, many established clinical VTE risk factors such as surgery, obesity, cystic fibrosis, sepsis, systemic infection, cancer, inflammatory bowel disease, and lupus likely modulate thrombosis through inflammatory mediators...
2018: Frontiers in Pediatrics
Knut A Mosevoll, Silje Johansen, Øystein Wendelbo, Ina Nepstad, Øystein Bruserud, Håkon Reikvam
The inflammatory response is a well-established part of, and a prerequisite for, venous thrombosis. To better understand the pathophysiology of venous thrombosis and to identify improved diagnostic biomarkers, further studies of the relationship between inflammation and coagulation are needed. We review previous studies concerning inflammatory biomarkers in venous thromboembolism, in particular cytokines, soluble adhesion molecules and matrix metalloproteases as predisposing, diagnostic and prognostic factors in venous thrombosis...
2018: Frontiers in Medicine
Fred G Pluthero, Jorge Di Paola, Manuel D Carcao, Walter H A Kahr
Homozygosity/compound heterozygosity for loss of function mutations in neurobeachin-like 2 (NBEAL2) is causative for Gray platelet syndrome (GPS; MIM #139090), characterized by thrombocytopenia and large platelets lacking α-granules and cargo. Most GPS-associated NBEAL2 mutations generate nonsense codons; frameshifts causing premature translation termination and/or changes in mRNA splicing have also been observed. Data regarding NBEAL2 protein expression in GPS patients is limited. We observed absence of NBEAL2 in platelets from GPS patients with 3 different genotypes, and reduced/truncated platelet NBEAL2 has been reported for others...
June 5, 2018: Platelets
Junmei Chen, Dominic W Chung
There is increasing evidence that inflammation can cause thrombosis by a von Willebrand factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF, assembly of hyperadhesive VWF strings and fibers, cleavage by ADAMTS13, adhesion and deposition of VWF-platelet thrombi in the vasculature. This mechanism appears to contribute to thrombosis not only in small vessels, but large vessels as well. Inflammation and VWF contributes to atherogenesis and may contribute to arterial and venous thrombosis, and stroke...
June 4, 2018: Blood
Christian Schoergenhofer, Michael Schwameis, Georg Gelbenegger, Nina Buchtele, Barbara Thaler, Marion Mussbacher, Gernot Schabbauer, Johann Wojta, Petra Jilma-Stohlawetz, Bernd Jilma
The protease-activated receptor-1 (PAR-1) is critically involved in the co-activation of coagulation and inflammatory responses. Vorapaxar is a reversible, orally active, low molecular weight, competitive antagonist of PAR-1.We investigated the effects of PAR-1 inhibition by vorapaxar on the inflammatory response, the activation of coagulation, fibrinolysis and endothelium during experimental endotoxemia. In this randomized, double blind, crossover trial, 16 healthy volunteers received a bolus infusion of 2 ng/kg lipopolysaccharide (LPS) ± placebo/vorapaxar with a washout period of 8 weeks...
June 4, 2018: Thrombosis and Haemostasis
Dan Liu, Yu Cao, Xiaolin Zhang, Chengfei Peng, Xiaoxiang Tian, Chenghui Yan, Yanxia Liu, Meili Liu, Yaling Han
BACKGROUND: Studies indicate that chemokine CC-motif ligand 2 (CCL2) is involved in inflammation and atherosclerosis. However, the roles and mechanisms of CCL2 on platelet function and arterial thrombosis are unknown. METHODS: The expressions of CCL2 or CCR2 in the plasma, platelets and coronary thrombus of ST-elevated myocardial infarction (STEMI) patients were examined by ELISA, Western blot, immunohistochemistry and immunofluorescence. The roles of CCL2 on platelet aggregation, activation and secretion were examined by light transmission aggregometry, flow cytometry and ELISA...
June 1, 2018: Biochimica et Biophysica Acta
Katsue Suzuki-Inoue
Podoplanin is a type-I transmembrane sialomucin-like glycoprotein expressed on the surface of several kinds of tumor cells. The podoplanin receptor is a platelet activation receptor known as C-type lectin-like receptor 2 (CLEC-2), which has been identified as a receptor for the platelet-activating snake venom protein rhodocytin. CLEC-2 is highly expressed in platelets and megakaryocytes and expressed at lower levels in liver Kupffer cells. Podoplanin is expressed in certain types of tumor cells, including squamous cell carcinomas, seminomas, and brain tumors...
June 4, 2018: Platelets
Elmina Mammadova-Bach, Maximilian Mauler, Attila Braun, Daniel Duerschmied
Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT transporters (5-HTTs) have been identified in the vasculature and blood cells, beyond them 5-HTT is the major 5-HT transporter in platelets. Abnormal 5-HT concentrations in the blood plasma or increased platelet 5-HT uptake or abnormal release contribute to the development of various diseases in the vasculature. Consequently, several clinical trials suggested the positive therapeutic effects of 5-HTT blockade in the circulation...
June 4, 2018: Platelets
A M Al-Yahya, A A Al-Masri, E A El Eter, A Hersi, R Lateef, O Mawlana
OBJECTIVE: Several adipokines secreted by adipose tissue have an anti-thrombotic and anti-atherosclerotic function. Recently identified adipokine progranulin was found to play a protective role in atherosclerosis. Bearing in mind the central role of platelets in inflammation and atherosclerosis, we aimed, in this study, to examine the effect of progranulin on platelet function and coagulation profile in rats. MATERIALS AND METHODS: Healthy male albino Wistar rats weighing (250-300 g) were divided into 4 groups...
May 2018: European Review for Medical and Pharmacological Sciences
Yongyin Gao, Hongdian Zhang, Yue Li, Dandan Wang, Yinlu Ma, Qing Chen
BACKGROUND: A novel systemic immune-inflammation index (SII) has been recently reported to be associated with clinical outcome in several tumors. However, the prognostic value of SII has not been reported in operable non-small cell lung carcinoma (NSCLC). We aimed to investigate its clinical and prognostic value in patients with operable NSCLC underwent curative surgery. METHODS: Four hundred ten NSCLC patients staged I-IIIA were included in this retrospective study...
May 31, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kentaro Nakano, Kumiya Sugiyama, Hideyuki Satoh, Sadaaki Shiromori, Kei Sugitate, Hajime Arifuku, Naruo Yoshida, Hiroyoshi Watanabe, Shingo Tokita, Tomoshige Wakayama, Masamitsu Tatewaki, Ryosuke Souma, Kenya Koyama, Hirokuni Hirata, Yasutsugu Fukushima
BACKGROUND: The mortality rate from disseminated intravascular coagulation (DIC) is higher in patients with lung cancer than in non-lung cancer patients. Moreover, the prevalence of DIC varies among the pathologic types of lung cancer. This study analyzed the relationship between coagulation factors and the pathologic types of lung cancer. METHODS: Twenty-six patients with progressive, inoperable stage IIB or higher lung cancer (20 men, 6 women; mean age 71 years; 11 Adeno, 10 squamous cell carcinoma, and 5 small cell carcinoma) and five healthy volunteers without respiratory disease (3 men, 2 women; mean age 72 years) were enrolled in the study...
May 31, 2018: Thoracic Cancer
Chen Zou, Minjie Zhao, Jingjing Yu, Dandan Zhu, Yunzhi Wang, Xinping She, Yanan Hu, Zhi Zheng
Purpose: To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods: Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n = 9) and without (PDR group; n = 8) preoperative IVC. Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview differentially expressed proteins between each group...
2018: Journal of Ophthalmology
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