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https://www.readbyqxmd.com/read/29928398/hydrogen-rich-solution-attenuates-myocardial-injury-caused-by-cardiopulmonary-bypass-in-rats-via-the-janus-activated-kinase-2-signal-transducer-and-activator-of-transcription-3-signaling-pathway
#1
Keyan Chen, Yingjie Sun, Yugang Diao, Tiezheng Zhang, Wanwei Dong
The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to investigate its potential regulation of the Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29926926/inactivated-piscine-orthoreovirus-vaccine-protects-against-heart-and-skeletal-muscle-inflammation-in-atlantic-salmon
#2
Øystein Wessel, Øyvind Haugland, Marit Rode, Børge N Fredriksen, Maria K Dahle, Espen Rimstad
Heart- and skeletal muscle inflammation (HSMI) caused by infection with Piscine orthoreovirus (PRV) is one of the most common viral diseases in farmed Atlantic salmon (Salmo salar) in Norway, and disease outbreaks have been reported in most countries with large-scale Atlantic salmon aquaculture. Currently there is no vaccine available for protection against HSMI, partly due to the lack of a cell line for efficient virus propagation. Erythrocytes are the primary target cells for PRV in vivo and a potential source for isolation of PRV particles...
June 21, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29925681/camkii%C3%AE-mediated-inflammatory-gene-expression-and-inflammasome-activation-in-cardiomyocytes-initiate-inflammation-and-induce-fibrosis
#3
Andrew Willeford, Takeshi Suetomi, Audrey Nickle, Hal M Hoffman, Shigeki Miyamoto, Joan Heller Brown
Inflammation accompanies heart failure and is a mediator of cardiac fibrosis. CaMKIIδ plays an essential role in adverse remodeling and decompensation to heart failure. We postulated that inflammation is the mechanism by which CaMKIIδ contributes to adverse remodeling in response to nonischemic interventions. We demonstrate that deletion of CaMKIIδ in the cardiomyocyte (CKO) significantly attenuates activation of NF-κB, expression of inflammatory chemokines and cytokines, and macrophage accumulation induced by angiotensin II (Ang II) infusion...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29925515/change-in-inflammatory-biomarkers-and-adipose-tissue-in-brca1-2-breast-cancer-survivors-following-a-year-long-lifestyle-modification-program
#4
Kathleen M Sturgeon, Wayne Y Foo, Mariane L Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically-induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants (N=35) were BRCA1/2+, breast cancer survivors, and had completed surgically-induced menopause at age <45 years...
June 20, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29925128/-comparative-study-on-deep-venous-thrombosis-onset-in-hospitalized-patients-with-different-underlying-diseases
#5
M L Sun, X H Wang, J Huang, J Wang, Y Wang
Objective: To improve the understanding of deep venous thrombosis (DVT), the present study was conducted to investigate the difference of DVT onset in hospitalized patients with different underlying diseases. Methods: This is a single-center retrospective study from Beijing Shijitan Hospital. Clinical data from hospital onset DVT patients from 2007 to 2016 were collected. DVT was confirmed with compression ultrasonography (CUS), color Doppler flow imaging (CDFI), CT venography (CTV), magnetic resonance venography (MRV), lower extremities radionuclide venography(RDV) or conventional venography (CV)...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924642/increased-cytokines-at-high-altitude-lack-of-effect-of-ibuprofen-on-acute-mountain-sickness-physiological-variables-or-cytokine-levels
#6
Jenny Lundeberg, John R Feiner, Andrew Schober, Jeffrey W Sall, Helge Eilers, Philip E Bickler
Lundeberg, Jenny, John R. Feiner, Andrew Schober, Jeffrey W. Sall, Helge Eilers, and Philip E. Bickler. Increased cytokines at high altitude: lack of effect of ibuprofen on acute mountain sickness, physiological variables or cytokine levels. High Alt Med Biol. 00:000-000, 2018. INTRODUCTION: There is no consensus on the role of inflammation in high-altitude acclimatization. AIMS: To determine the effects of a nonsteroidal anti-inflammatory drug (ibuprofen 400 mg every 8 hours) on blood cytokines, acclimatization, acute mountain sickness (AMS, Lake Louise Score), and noninvasive oxygenation in brain and muscle in healthy volunteers...
June 20, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29922941/cardioprotective-and-functional-effects-of-levosimendan-and-milrinone-in-mice-with-cecal-ligation-and-puncture-induced-sepsis
#7
Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, Yasuhide Watanabe, Naoyuki Matsuda, Naoki Yoshimura, Yuichi Hattori
Levosimendan and milrinone may be used in place of dobutamine to increase cardiac output in septic patients with a low cardiac output due to impaired cardiac function. The effects of the two inotropic agents on cardiac inflammation and left ventricular (LV) performance were examined in mice with cecal ligation and puncture (CLP)-induced sepsis. CLP mice displayed significant cardiac inflammation, as indicated by highly increased pro-inflammatory cytokines and neutrophil infiltration in myocardial tissues. When continuously given, levosimendan prevented but milrinone exaggerated cardiac inflammation, but they significantly reduced the elevations in plasma cardiac troponin-I and heart-type fatty acid-binding protein, clinical markers of cardiac injury...
June 20, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29920999/anti-apoptotic-effects-of-adipose-derived-adherent-stromal-cells-in-mesenchymal-stem-cells-exposed-to-oxidative-stress
#8
Sunhye Shin, Jung-Won Choi, Soyeon Lim, Seahyoung Lee, Eun-Young Jun, Hyun-Min Sun, Il-Kwon Kim, Hoon-Bum Lee, Sang Woo Kim, Ki-Chul Hwang
Adipose-derived stromal vascular fractions (SVFs) are a heterogeneous collection of cells, and their regenerative modality has been applied in various animal experiments and clinical trials. Despite the attractive advantages of SVFs in clinical interventions, the recent status of clinical studies involving the application of SVFs in many diseases has not been fully evaluated. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types despite their low numbers in heart tissue...
June 19, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29920341/high-and-low-affinity-pegylated-hemoglobin-based-oxygen-carriers-differential-oxidative-stress-in-a-guinea-pig-transfusion-model
#9
Esra'a Ali Mohammad Alomari, Luca Ronda, Stefano Bruno, Gianluca Paredi, Marialaura Marchetti, Stefano Bettati, Davide Olivari, Francesca Fumagalli, Deborah Novelli, Giuseppe Ristagno, Roberto Latini, Chris E Cooper, Brandon J Reeder, Andrea Mozzarelli
Hemoglobin (Hb)-based oxygen carriers (HBOCs) are an investigational replacement for blood transfusions and are known to cause oxidative damage to tissues. To investigate the correlation between their oxygen binding properties and these detrimental effects, we investigated two PEGylated HBOCs endowed with different oxygen binding properties - but otherwise chemically identical - in a Guinea pig transfusion model. Plasma samples were analyzed for biochemical markers of inflammation, tissue damage and organ dysfunction; proteins and lipids of heart and kidney extracts were analyzed for markers of oxidative damage...
June 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29916098/the-effects-of-xanthine-oxidase-inhibitor-in-patients-with-chronic-heart-failure-complicated-with-hyperuricemia-a-prospective-randomized-controlled-clinical-trial-of-topiroxostat-vs-allopurinol-study-protocol
#10
Masashi Sakuma, Shigeru Toyoda, Takuo Arikawa, Yota Koyabu, Toru Kato, Taichi Adachi, Hideaki Suwa, Jun-Ichi Narita, Koetsu Anraku, Kimihiko Ishimura, Fumitake Yamauchi, Yasunori Sato, Teruo Inoue
BACKGROUND: Hyperuricemia has a close relationship with cardiovascular diseases including heart failure. However, it is controversial whether xanthine oxidase inhibition has benefits for patients with chronic heart failure. We designed the Effect of Xanthine Oxidase Inhibitor in Chronic Heart Failure Patients Complicated with Hyperuricemia study (Excited-UA study) to compare the beneficial effects between a novel xanthine oxidoreductase inhibitor, topiroxostat, and a conventional agent, allopurinol, in patients with chronic heart failure and hyperuricemia...
June 18, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29916025/short-term-weight-loss-reverses-obesity-induced-microvascular-endothelial-dysfunction
#11
Tamas Csipo, Gabor A Fulop, Agnes Lipecz, Stefano Tarantini, Tamas Kiss, Priya Balasubramanian, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging...
June 18, 2018: GeroScience
https://www.readbyqxmd.com/read/29914983/inhibition-of-the-cyclophilin-a-cd147-interaction-attenuates-right-ventricular-injury-and-dysfunction-after-acute-pulmonary-embolism-in-rats
#12
Guangdong Lu, Zhenyu Jia, Qingquan Zu, Jinxing Zhang, Linbo Zhao, Haibin Shi
Acute pulmonary embolism (APE)-induced inflammation contributes to cardiomyocyte injury and dysfunction in the right ventricle (RV) of the heart. The interactions of cyclophilin A with its ligand extracellular matrix metalloproteinase inducer (EMMPRIN or CD147) may be involved in this inflammatory process. To this end, here we induced APE by intravenous injections of microspheres in Sprague-Dawley rats. We found that after the APE, cyclophilin A, and CD147 levels increased synchronously in RV tissue following APE and peaked at 24 hours...
June 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29913437/thymoquinone-attenuates-myocardial-ischemia-reperfusion-injury-through-activation-of-sirt1-signaling
#13
Yunyang Lu, Yingda Feng, Dan Liu, Zhiran Zhang, Kai Gao, Wei Zhang, Haifeng Tang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (MI/R) injury is a leading factor responsible for damage in myocardial infarction, resulting in additional injury to cardiac tissues involved in oxidative stress, inflammation, and apoptosis. Thymoquinone (TQ), the main constituent of Nigella sativa L. seeds, has been reported to possess various biological activities. However, few reports regarding myocardial protection are available at present. Therefore, this study was conducted aiming to investigate the protective effect of TQ against MI/R injury and to clarify its potential mechanism...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29910817/treating-heart-inflammation-with-interleukin-1-blockade-in-a-case-of-erdheim-chester-disease
#14
Alessandro Tomelleri, Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, Teresa D'Aliberti, Moreno Tresoldi, Lorenzo Dagna
Pericarditis is an inflammatory heart disease, which may be idiopathic or secondary to autoimmune or auto-inflammatory diseases and often leads to severe or life-threatening complications. Colchicine and non-steroidal anti-inflammatory drugs represent the mainstay of treatment, whereas use of corticosteroids is associated with recurrence of disease flares. While effective and safe anti-inflammatory therapies remain an unmet clinical need, emerging clinical and experimental evidence points at a promising role of inhibition of the pro-inflammatory cytokine interleukin-1 (IL-1)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909553/increasing-quality-of-life-in-pulmonary-arterial-hypertension-is-there-a-role-for-nutrition
#15
REVIEW
Paulien Vinke, Suzanne M Jansen, Renger F Witkamp, Klaske van Norren
Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue, negatively affecting their quality of life. This review summarizes current insights in the pathophysiological mechanisms underlying PAH. It zooms in on the potential involvement of nutritional status and micronutrient deficiencies on PAH exercise intolerance and fatigue, also summarizing the potential benefits of exercise and nutritional interventions...
June 16, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29908857/midlife-contributors-to-socioeconomic-differences-in-frailty-during-later-life-a-prospective-cohort-study
#16
Eric J Brunner, Martin J Shipley, Sara Ahmadi-Abhari, Carlos Valencia Hernandez, Jessica G Abell, Archana Singh-Manoux, Ichiro Kawachi, Mika Kivimaki
BACKGROUND: Health inequalities persist into old age. We aimed to investigate risk factors for socioeconomic differences in frailty that could potentially be modified through policy measures. METHODS: In this multi-wave longitudinal cohort study (Whitehall II study), we assessed participants' socioeconomic status, behavioural and biomedical risk factors, and disease status at age 45-55 years, and frailty (defined according to the Fried phenotype) at baseline and at one or more of three clinic visits about 18 years later (mean age 69 years [SD 5·9])...
June 13, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#17
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29907596/inflammation-leads-through-pge-ep-3-signaling-to-hdac5-mef2-dependent-transcription-in-cardiac-myocytes
#18
András D Tóth, Richard Schell, Magdolna Lévay, Christiane Vettel, Philipp Theis, Clemens Haslinger, Felix Alban, Stefanie Werhahn, Lina Frischbier, Jutta Krebs-Haupenthal, Dominique Thomas, Hermann-Josef Gröne, Metin Avkiran, Hugo A Katus, Thomas Wieland, Johannes Backs
The myocyte enhancer factor 2 (MEF2) regulates transcription in cardiac myocytes and adverse remodeling of adult hearts. Activators of G protein-coupled receptors (GPCRs) have been reported to activate MEF2, but a comprehensive analysis of GPCR activators that regulate MEF2 has to our knowledge not been performed. Here, we tested several GPCR agonists regarding their ability to activate a MEF2 reporter in neonatal rat ventricular myocytes. The inflammatory mediator prostaglandin E2 (PGE2 ) strongly activated MEF2...
June 15, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29906340/sympatho-excitatory-response-to-pulmonary-chemosensitive-spinal-afferent-activation-in-anesthetized-vagotomized-rats
#19
Julia Shanks, Zhiqiu Xia, Steven J Lisco, George J Rozanski, Harold D Schultz, Irving H Zucker, Han-Jun Wang
The sensory innervation of the lung is well known to be innervated by nerve fibers of both vagal and sympathetic origin. Although the vagal afferent innervation of the lung has been well characterized, less is known about physiological effects mediated by spinal sympathetic afferent fibers. We hypothesized that activation of sympathetic spinal afferent nerve fibers of the lung would result in an excitatory pressor reflex, similar to that previously characterized in the heart. In this study, we evaluated changes in renal sympathetic nerve activity (RSNA) and hemodynamics in response to activation of TRPV1-sensitive pulmonary spinal sensory fibers by agonist application to the visceral pleura of the lung and by administration into the primary bronchus in anesthetized, bilaterally vagotomized, adult Sprague-Dawley rats...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905796/heart-failure-with-preserved-ejection-fraction-from-mechanisms-to-therapies
#20
Carolyn S P Lam, Adriaan A Voors, Rudolf A de Boer, Scott D Solomon, Dirk J van Veldhuisen
This review aims to provide a translational perspective on recent developments in heart failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential therapies. A key concept in this review is that HFpEF is a haemodynamic condition wherein the heart fails to keep up with the circulatory demands of the body, or does so at the expense of raised left ventricular filling pressures. We, therefore, propose that the 'final common pathway' for development of congestion, i.e. basic haemodynamic mechanisms of increased left ventricular end-diastolic pressure, left atrial hypertension, pulmonary venous congestion, and plasma volume expansion, represents important initial targets for therapy in HFpEF...
June 13, 2018: European Heart Journal
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