Chiara Tremolanti, Elisa Angeloni, Eleonora Da Pozzo, Lorenzo Germelli, Chiara Giacomelli, Eduardo Scalzi, Sabrina Taliani, Federico Da Settimo, Ayikoé-Guy Mensah-Nyagan, Claudia Martini, Barbara Costa
Mature oligodendrocytes (OLs) arise from oligodendrocyte precursor cells that, in case of demyelination, are recruited at the lesion site to remyelinate the axons and therefore restore the transmission of nerve impulses. It has been widely documented that exogenously administered steroid molecules are potent inducers of myelination. However, little is known about how neurosteroids produced de novo by OLs can impact this process. Here, we employed a human OL precursor cell line to investigate the role of de novo neurosteroidogenesis in the regulation of OLs differentiation, paying particular attention to the 18 kDa Translocator Protein (TSPO) which controls the rate-limiting step of the neurosteroidogenic process...
April 15, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease