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Quantitative sensory testing

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https://www.readbyqxmd.com/read/28719619/diagnostic-utility-of-corneal-confocal-microscopy-and-intra-epidermal-nerve-fibre-density-in-diabetic-neuropathy
#1
Uazman Alam, Maria Jeziorska, Ioannis N Petropoulos, Omar Asghar, Hassan Fadavi, Georgios Ponirakis, Andrew Marshall, Mitra Tavakoli, Andrew J M Boulton, Nathan Efron, Rayaz A Malik
OBJECTIVES: Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established measures of nerve damage in patients with diabetic neuropathy. METHODS: In this cross sectional study, thirty subjects with Type 1 diabetes without neuropathy (T1DM), thirty one T1DM subjects with neuropathy (DSPN) and twenty seven non-diabetic healthy control subjects underwent detailed assessment of neuropathic symptoms and neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy and corneal confocal microscopy (CCM)...
2017: PloS One
https://www.readbyqxmd.com/read/28715356/a-mouse-model-for-pain-and-neuroplastic-changes-associated-with-pancreatic-ductal-adenocarcinoma
#2
Deepitha Selvaraj, Michael Hirth, Jagadeesh Gandla, Rohini Kuner
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest human malignancies and is associated with excruciating pain, which is a serious complication and severely impacts the quality of life in patients. In human patients, poor survival prognosis is linked to remarkable remodeling of intrapancreatic nerves, which, in turn, is correlated to increased pain intensity. Understanding mechanisms underlying pain associated with PDAC has been hampered by the lack of animal models which replicate all germane aspects of the disease and importantly, enable analyses of pain associated with PDAC...
August 2017: Pain
https://www.readbyqxmd.com/read/28713038/assessment-of-sexual-function-in-women-with-neurological-disorders-a-review
#3
REVIEW
Frédérique Courtois, Marina Gérard, Kathleen Charvier, David B Vodušek, Gérard Amarenco
BACKGROUND: Although the rehabilitation of sexual function has been identified as a top priority among women presenting neurological conditions, sexual function is rarely assessed in this clinical group. OBJECTIVES: To review published assessment tools of sexual dysfunction in women with neurological conditions including multiple sclerosis (MS), spinal cord injury (SCI), Parkinson disease, stroke, traumatic brain injury. METHODS: A systematic literature review was conducted with Medline via PubMed, PubMed Central, and Medline databases...
July 13, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28700537/qst-response-patterns-to-capsaicin-and-uv-b-induced-local-skin-hypersensitization-in-healthy-subjects-a-machine-learned-analysis
#4
Jörn Lötsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch, Bruno G Oertel, Alfred Ultsch
The comprehensive assessment of pain-related human phenotypes requires combinations of nociceptive measures that produce complex high-dimensional data, posing challenges to bioinformatic analysis. In this study, we assessed established experimental models of heat hyperalgesia of the skin, consisting of local ultraviolet-B (UV-B) irradiation or capsaicin application, in 82 healthy subjects using a variety of noxious stimuli. We extended the original heat simulation by applying cold and mechanical stimuli and assessing the hypersensitization effects with a clinically established quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain)...
July 8, 2017: Pain
https://www.readbyqxmd.com/read/28698221/patellar-and-achilles-tendinopathies-are-predominantly-peripheral-pain-states-a-blinded-case-control-study-of-somatosensory-and-psychological-profiles
#5
Melanie L Plinsinga, Cornelis P van Wilgen, Michel S Brink, Viana Vuvan, Aoife Stephenson, Luke J Heales, Rebecca Mellor, Brooke K Coombes, Bill T Vicenzino
STUDY DESIGN: Case-control design. BACKGROUND: Tendinopathy is characterised by pain on tendon loading. In persistent cases of upper limb tendinopathy, it is frequently associated with central nervous system sensitisation, whereas less commonly linked in the case of persistent lower limb tendinopathies. OBJECTIVES: Compare somatosensory and psychological profiles of participants with persistent patellar (PT) and Achilles tendinopathies (AT) with pain-free controls...
July 11, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28694674/mechanisms-of-chronic-pain-key-considerations-for-appropriate-physical-therapy-management
#6
Carol A Courtney, César Fernández-de-Las-Peñas, Samantha Bond
In last decades, knowledge of nociceptive pain mechanisms has expanded rapidly. The use of quantitative sensory testing has provided evidence that peripheral and central sensitization mechanisms play a relevant role in localized and widespread chronic pain syndromes. In fact, almost any patient suffering with a chronic pain condition will demonstrate impairments in the central nervous system. In addition, it is accepted that pain is associated with different types of trigger factors including social, physiological, and psychological...
July 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28694209/genome-wide-identification-and-expression-profiling-of-the-sox-gene-family-in-a-bivalve-mollusc-patinopecten-yessoensis
#7
Jiachen Yu, Lingling Zhang, Yangping Li, Ruojiao Li, Meiwei Zhang, Wanru Li, Xinran Xie, Shi Wang, Xiaoli Hu, Zhenmin Bao
SOX family is composed of transcription factors that play vital roles in various developmental processes. Comprehensive understanding on evolution of the SOX family requires full characterization of SOX genes in different phyla. Mollusca is the second largest metazoan phylum, but till now, systematic investigation on the SOX family is still lacking in this phylum. In this study, we conducted genome-wide identification of the SOX family in Yesso scallop Patinopecten yessoensis and profiled their tissue distribution and temporal expression patterns in the ovaries and testes during gametogenesis...
July 7, 2017: Gene
https://www.readbyqxmd.com/read/28686664/somatosensory-function-in-patients-with-secondary-adrenal-insufficiency-treated-with-two-different-doses-of-hydrocortisone-results-from-a-randomized-controlled-trial
#8
Jorien Werumeus Buning, Karl-Heinz Konopka, Pauline Brummelman, Janneke Koerts, Robin P F Dullaart, Gerrit van den Berg, Melanie M van der Klauw, Oliver Tucha, Bruce H R Wolffenbuttel, André P van Beek
BACKGROUND: Low cortisol levels are associated with several functional pain syndromes. In patients with secondary adrenal insufficiency (SAI), the lack in endogenous cortisol production is substituted by the administration of oral hydrocortisone (HC). Our previous study showed that a lower dose of HC led to an increase in reported subjective pain symptoms. Whether different doses of HC substitution alter somatosensory functioning in SAI patients has not been established yet. METHODS: In this randomized double blind cross-over trial, forty-six patients with SAI participated...
2017: PloS One
https://www.readbyqxmd.com/read/28676377/is-there-a-connection-between-postprandial-hyperglycemia-and-igt-related-sensory-nerve-dysfunction
#9
N Németh, Z Putz, I Istenes, A E Körei, O E Vági, M Kempler, R Gandhi, G Jermendy, S Tesfaye, Á G Tabák, P Kempler
BACKGROUND AND AIMS: To assess the risk factors for sensory nerve dysfunction in subjects with isolated impaired glucose tolerance (IGT). METHODS AND RESULTS: Seventy-two people with isolated IGT (WHO 1999 criteria) and 39 gender and age-matched healthy volunteers underwent detailed clinical and neurological assessment including quantitative sensory testing using the Neurometer device (current perception threshold measurement on four limbs at three different frequencies)...
May 11, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28673764/how-to-assess-sensory-recovery-after-breast-reconstruction-surgery
#10
Helena K Puonti, Taina A Broth, Seppo O Soinila, Helena K Hallikainen, Satu K Jääskeläinen
BACKGROUND: We evaluated clinical against psychophysical (tactile and thermal quantitative sensory test [QST]), neurophysiologic (somatosensory evoked potential [SEP]), and epithelial nerve fiber density (ENFD) examinations in detection and follow-up of sensory alterations after breast reconstruction done with or without nerve anastomoses. PATIENTS AND METHODS: In a prospective 2-year follow-up design, 56 breast cancer patients underwent innervated and 20 patients noninnervated free rectus abdominis muscle-sparing flap (ms-TRAM) breast reconstruction...
April 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28654635/two-different-mechanisms-support-selective-attention-at-different-phases-of-training
#11
Sirawaj Itthipuripat, Kexin Cha, Anna Byers, John T Serences
Selective attention supports the prioritized processing of relevant sensory information to facilitate goal-directed behavior. Studies in human subjects demonstrate that attentional gain of cortical responses can sufficiently account for attention-related improvements in behavior. On the other hand, studies using highly trained nonhuman primates suggest that reductions in neural noise can better explain attentional facilitation of behavior. Given the importance of selective information processing in nearly all domains of cognition, we sought to reconcile these competing accounts by testing the hypothesis that extensive behavioral training alters the neural mechanisms that support selective attention...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28652589/congenital-deafness-is-associated-with-specific-somatosensory-deficits-in-adolescents
#12
Rabih Moshourab, Valérie Bégay, Christiane Wetzel, Jan Walcher, Steven Middleton, Manfred Gross, Gary R Lewin
Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14-20 years old) compared to age-matched individuals with congenital hearing loss. Sensory testing was performed on the dominant hand of 111 individuals with normal hearing and 36 with congenital hearing loss. Subjects with congenital deafness were characterized by significantly higher vibration detection thresholds at 10 Hz (2-fold increase, P < 0...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652290/imaging-pain-relief-in-osteoarthritis-ipro-protocol-of-a-double-blind-randomised-controlled-mechanistic-study-assessing-pain-relief-and-prediction-of-duloxetine-treatment-outcome
#13
Diane Reckziegel, Helen Bailey, William J Cottam, Christopher R Tench, Ravi P Mahajan, David A Walsh, Roger D Knaggs, Dorothee P Auer
INTRODUCTION: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current lack of understanding of mechanisms of chronic pain. Recently, duloxetine has demonstrated clinically relevant pain relief, but only in half of treated patients with OA. Here, the aim is to investigate the neural mechanisms of pain relief and neural signatures that may predict treatment response to duloxetine in chronic knee OA pain...
June 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28638591/replicable-in-vivo-physiological-and-behavioral-phenotypes-of-the-shank3b-null-mutant-mouse-model-of-autism
#14
Sameer C Dhamne, Jill L Silverman, Chloe E Super, Stephen H T Lammers, Mustafa Q Hameed, Meera E Modi, Nycole A Copping, Michael C Pride, Daniel G Smith, Alexander Rotenberg, Jacqueline N Crawley, Mustafa Sahin
BACKGROUND: Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify electroencephalographic (EEG) and behavioral phenotypes that are replicable between independent cohorts in a mouse model of ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28632555/changes-in-cytokines-sensory-tests-and-self-reported-pain-levels-after-manual-treatment-of-low-back-pain
#15
Brian F Degenhardt, Jane C Johnson, Christian Fossum, Chad T Andicochea, Melissa K Stuart
STUDY DESIGN: Unbalanced 3-factor design with repeated measures on 1 factor. OBJECTIVE: To determine the effect of manual treatment (MT) on cytokine and pain sensations in those with and without low back pain (LBP). SUMMARY OF BACKGROUND DATA: Evidence suggests that MT reduces LBP but by unknown mechanisms. Certain cytokines have been elevated in patients with LBP and may be affected by MT. METHODS: Participants aged 20-60 years with chronic LBP or without LBP were recruited and randomly assigned to MT, sham ultrasound treatment, or no treatment groups...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28623897/altered-somatosensory-profile-according-to-quantitative-sensory-testing-in-patients-with-degenerative-lumbar-spine-disorders-scheduled-for-surgery
#16
Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott, Birgitta Öberg
BACKGROUND: Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to identify the proportion with altered somatosensory profile, and to analyze demographic characteristics, self-reported function, pain, and health pre- and 3 months post-surgery...
June 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28619697/depression-and-pain-in-asian-and-white-americans-with-knee-osteoarthritis
#17
Hyochol Ahn, Michael Weaver, Debra Lyon, Eunyoung Choi, Roger B Fillingim
Few studies have examined the underlying psychosocial mechanisms of pain in Asian Americans. Using the biopsychosocial model, we sought to determine whether variations in depression contribute to racial group differences in symptomatic knee osteoarthritis pain between Asian Americans and non-Hispanic white Americans. The sample consisted of 100 participants, including 50 Asian Americans (28 Korean Americans, 9 Chinese Americans, 7 Japanese Americans, 5 Filipino Americans, and 1 Indian American) and 50 age- and sex-matched non-Hispanic white Americans with symptomatic knee osteoarthritis pain...
June 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28615966/acute-physiological-and-electrical-accentuation-of-vagal-tone-has-no-effect-on-pain-or-gastrointestinal-motility-in-chronic-pancreatitis
#18
Jacob Juel, Christina Brock, Søren S Olesen, Adnan Madzak, Adam D Farmer, Qasim Aziz, Jens B Frøkjær, Asbjørn Mohr Drewes
BACKGROUND: The effective management of pain in chronic pancreatitis (CP) remains a therapeutic challenge. Analgesic drugs, such as opioids, and the underlying pathology can impair gut function. The autonomic nervous system influences hormone secretion and gut motility. In healthy volunteers, electrical (using noninvasive transcutaneous vagal nerve stimulation [t-VNS]) and physiological (using deep slow breathing [DSB]) modulation of parasympathetic tone results in pain attenuation and enhanced gut motility...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28614190/non-histaminergic-and-mechanical-itch-sensitization-in-atopic-dermatitis
#19
H H Andersen, J Elberling, H Sølvsten, G Yosipovitch, L Arendt-Nielsen
Chronic or episodic severe itch is recurrent in atopic dermatitis (AD). Non-histaminergic neuronal itch pathways are suggested to dominate in AD itch, contributing to an "itch-scratch-itch cycle" that prolongs and worsens itch, pain, and skin lesions. We hypothesized that non-histaminergic neuronal sensitization contributes to itch in AD. Hence, we compared sensitivity to thermal, mechanical, and chemical pruritic stimuli in AD patients and controls. The study comprised 25 AD patients with chronic itch and 25 healthy controls...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28614189/a-dose-response-study-of-topical-allyl-isothiocyanate-mustard-oil-as-human-surrogate-model-of-pain-hyperalgesia-and-neurogenic-inflammation
#20
H H Andersen, S Lo Vecchio, P Gazerani, L Arendt-Nielsen
Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl-isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation. Its dose-response as an algogenic, sensitizing irritant remains to be elucidated in human skin. Three concentrations of AITC (10%, 50%, 90%) and vehicle (paraffin) were applied for 5 min to 3x3 cm areas on the volar forearms in 14 healthy volunteers, and evoked pain intensity (visual analog scale 0-100 mm) and pain quality were assessed...
June 9, 2017: Pain
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