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Quantitative sensory testing

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https://www.readbyqxmd.com/read/28091815/quantitative-validation-of-sensory-mapping-in-persistent-postherniorrhaphy-inguinal-pain-patients-undergoing-triple-neurectomy
#1
M F Bjurström, R Álvarez, A L Nicol, R Olmstead, P K Amid, D C Chen
PURPOSE: Neurectomy of the inguinal nerves may be considered for selected refractory cases of chronic postherniorrhaphy inguinal pain (CPIP). There is to date a paucity of easily applicable clinical tools to identify neuropathic pain and examine the neurosensory effects of remedial surgery. The present quantitative sensory testing (QST) pilot study evaluates a sensory mapping technique. METHODS: Longitudinal (preoperative, immediate postoperative, and late postoperative) dermatomal sensory mapping and a comprehensive QST protocol were conducted in CPIP patients with unilateral, predominantly neuropathic inguinodynia presenting for triple neurectomy (n = 13)...
January 13, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28065928/unveiling-the-osmophores-of-philodendron-adamantinum-araceae-as-a-means-to-understanding-interactions-with-pollinators
#2
Patrícia Gonçalves-Souza, Clemens Schlindwein, Stefan Dötterl, Elder Antônio Sousa Paiva
BACKGROUND AND AIMS: Araceae species pollinated by nocturnal Cyclocephalini beetles attract their pollinators by inflorescence scents. In Philodendron, despite the intense odour, the osmophores exhibit no definite morphological identity, making them difficult to locate. This may explain why structural studies of the scent-releasing tissue are not available so far. METHODS: Several approaches were employed for locating and understanding the osmophores of Philodendron adamantinum A sensory test allowed other analyses to be restricted to fertile and sterile stamens as odour production sites...
January 8, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28060784/differences-in-clinical-pain-and-experimental-pain-sensitivity-between-asian-americans-and-whites-with-knee-osteoarthritis
#3
Hyochol Ahn, Michael Weaver, Debra E Lyon, Junglyun Kim, Eunyoung Choi, Roland Staud, Roger B Fillingim
OBJECTIVE: Ethnicity has been associated with clinical and experimental pain responses. Whereas ethnic disparities in pain in other minority groups compared with whites are well described, pain in Asian Americans remains poorly understood. The purpose of this study was to characterize differences in clinical pain intensity and experimental pain sensitivity among older Asian American and non-Hispanic white (NHW) participants with knee osteoarthritis (OA). METHODS: Data were collected from 50 Asian Americans ages 45 to 85 (28 Korean, 9 Chinese, 7 Japanese, 5 Filipino, and 1 Indian) and compared with 50 age-matched and sex-matched NHW individuals with symptomatic knee OA pain...
February 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28060498/1-8-cineole-in-french-red-wines-evidence-for-a-contribution-related-to-its-various-origins
#4
Xavier Poitou, Cécile Thibon, Philippe Darriet
The aromatic descriptor "green", reflecting grape unripeness in French red wines, is frequently associated with the levels of 3-alkyl-2-methoxypyrazines, particularly 3-isobutyl-2-methoxypyrazine (IBMP), which has bell pepper nuances. Nevertheless, not all green aromatic expressions in red wines correlate with 3-alkyl-2-methoxypyrazine concentrations. This study considered sensory and chemical approaches using Cabernet Sauvignon wines obtained from grapes harvested at one-month intervals during the 2014 and 2015 vintages to investigate other volatile odoriferous compounds...
January 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28060280/a-protocol-of-manual-tests-to-measure-sensation-and-pain-in-humans
#5
Matthew Kostek, Anna Polaski, Benedict Kolber, Austin Ramsey, Alexander Kranjec, Kimberly Szucs
Numerous qualitative and quantitative techniques can be used to test sensory nerves and pain in both research and clinical settings. The current study demonstrates a quantitative sensory testing protocol using techniques to measure tactile sensation and pain threshold for pressure and heat using portable and easily accessed equipment. These techniques and equipment are ideal for new laboratories and clinics where cost is a concern or a limiting factor. We demonstrate measurement techniques for the following: cutaneous mechanical sensitivity on the arms and legs (von-Frey filaments), radiant and contact heat sensitivity (with both threshold and qualitative assessments using the Visual Analog Scale (VAS)), and mechanical pressure sensitivity (algometer, with both threshold and the VAS)...
December 19, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28050051/discordant-dry-eye-disease-an-american-ophthalmological-society-thesis
#6
Roni M Shtein, Daniel E Harper, Vincent Pallazola, Steven E Harte, Munira Hussain, Alan Sugar, David A Williams, Daniel J Clauw
PURPOSE: To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition. METHODS: Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28046047/expectation-or-sensorial-reality-an-empirical-investigation-of-the-biodynamic-calendar-for-wine-drinkers
#7
Wendy V Parr, Dominique Valentin, Phil Reedman, Claire Grose, James A Green
The study's aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors...
2017: PloS One
https://www.readbyqxmd.com/read/28039318/a-quantitative-meta-analysis-of-olfactory-dysfunction-in-mild-cognitive-impairment
#8
David R Roalf, Madelyn J Moberg, Bruce I Turetsky, Laura Brennan, Sushila Kabadi, David A Wolk, Paul J Moberg
BACKGROUND: The connection between Alzheimer's disease (AD) and olfactory deficits is well documented and further, alterations in olfactory functioning may signal declines in functions associated with dementia. The aim of the present comprehensive meta-analysis was to investigate the nature of olfactory deficits in mild cognitive impairment (MCI). METHODS: Articles were identified through computerised literature search from inception to 30 June 2016 using PubMed, MEDLINE and PsychInfo databases...
December 30, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28034986/influence-of-sexual-hormones-on-neural-orofacial-perception
#9
Bruna Alves, Flavia Ibuki, Alyne Simões Gonçalves, Manoel Jacobsen Teixeira, Silvia Regina Dowgan Tesseroli De Siqueira
OBJECTIVE  : To investigate the trigeminal somatosensory (thermal, pain, tactile, vibratory, and electric), gustative (salty, bitter, sweet, sour), and olfactory thresholds in healthy women during the menstrual cycle and investigate any association with estradiol and progesterone levels in saliva. METHODS : We examined/tested 39 women between age 19 and 47 years and with regular menstrual cycles and no comorbidities. All women were informed about the purposes of the study, and only those who signed the informed consent were included...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28027302/stereotypical-escape-behavior-in-caenorhabditis-elegans-allows-quantification-of-effective-heat-stimulus-level
#10
Kawai Leung, Aylia Mohammadi, William S Ryu, Ilya Nemenman
A goal of many sensorimotor studies is to quantify the stimulus-behavioral response relation for specific organisms and specific sensory stimuli. This is especially important to do in the context of painful stimuli since most animals in these studies cannot easily communicate to us their perceived levels of such noxious stimuli. Thus progress on studies of nociception and pain-like responses in animal models depends crucially on our ability to quantitatively and objectively infer the sensed levels of these stimuli from animal behaviors...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/28025370/prognosis-after-surgical-treatment-of-trigeminal-neuropathy-with-a-pga-c-tube-report-of-10-cases
#11
Kenji Seo, Makoto Terumitsu, Yuji Inada, Tatsuo Nakamura, Keiji Shigeno, Yutaka Tanaka
OBJECTIVE: Although surgery using a polyglycolic acid-collagen (PGA-c) tube is effective for peripheral nerve injury-induced chronic hand pain, it has not been applied to trigeminal nerve lesions because of the difficult approach. We used a PGA-c tube during surgery for trigeminal neuropathy and evaluated its prognosis based on the outcomes. DESIGN: Case report. SETTING AND PATIENTS: In the dental anesthesia division of a university hospital, 11 patients with severe dysesthesia underwent surgical repair of a damaged lingual nerve (LN) or inferior alveolar nerve (IAN)...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28009675/effects-of-foot-and-ankle-devices-on-balance-gait-and-falls-in-adults-with-sensory-perception-loss-a-systematic-review
#12
Joanne Paton, Anna L Hatton, Keith Rome, Bridie Kent
BACKGROUND: Foot and ankle devices are being developed as a method of preventing people with sensory perception loss sustaining a fall. Such devices are believed to work by reducing the likelihood of a fall by improving the balance and gait of the user. OBJECTIVES: The objective of the review was to evaluate the effectiveness of foot and ankle devices for the prevention of falls and the improvement of balance and gait in adults with sensory perception loss. INCLUSION CRITERIA TYPES OF PARTICIPANTS: Participants were community-dwelling adults with bilateral pathological sensory perception loss...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28008644/test-retest-reliability-of-quantitative-sensory-testing-for-mechanical-somatosensory-and-pain-modulation-assessment-of-masticatory-structures
#13
Yuri M Costa, Orlando Morita-Neto, Everardo N S de Araújo-Júnior, Fernanda A Sampaio, Paulo César R Conti, Leonardo R Bonjardim
BACKGROUND: Assessing the reliability of medical measurements is a crucial step toward the elaboration of an applicable clinical instrument. There are few studies that evaluate the reliability of somatosensory assessment and pain modulation of masticatory structures. OBJECTIVES: To estimate the test-retest reliability, i.e., over time, of the mechanical somatosensory assessment of anterior temporalis, masseter and temporomandibular joint (TMJ) and the conditioned pain modulation (CPM) using the anterior temporalis as the test site...
December 23, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28004244/gender-differences-after-lumbar-sequestrectomy-a-prospective-clinical-trial-using-quantitative-sensory-testing
#14
Anja Tschugg, Wolfgang N Löscher, Sara Lener, Matthias Wildauer, Sebastian Hartmann, Sabrina Neururer, Claudius Thomé
BACKGROUND: Quantitative sensory testing (QST) gained popularity to evaluate the time course of recovery in sensory dysfunction and the results of different treatment options. Concerning sex differences in lumbar spine surgery, female gender seems to play a major role as a negative prognostic factor in different spinal disorders. For this purpose, we hypothesised that there are also comparable differences in pain patterns in men and women after lumbar sequestrectomy using QST. METHODS: We applied the QST protocol of the German Research Network on Neuropathic Pain in 53 patients (21 women and 32 men) with a single lumbar disc herniation confirmed on MRI treated by a lumbar sequestrectomy...
December 21, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27994563/estimation-and-identifiability-of-model-parameters-in-human-nociceptive-processing-using-yes-no-detection-responses-to-electrocutaneous-stimulation
#15
Huan Yang, Hil G E Meijer, Jan R Buitenweg, Stephan A van Gils
Healthy or pathological states of nociceptive subsystems determine different stimulus-response relations measured from quantitative sensory testing. In turn, stimulus-response measurements may be used to assess these states. In a recently developed computational model, six model parameters characterize activation of nerve endings and spinal neurons. However, both model nonlinearity and limited information in yes-no detection responses to electrocutaneous stimuli challenge to estimate model parameters. Here, we address the question whether and how one can overcome these difficulties for reliable parameter estimation...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27960285/new-sweet-tasting-c21-pregnane-glycosides-from-pericarps-of-myriopteron-extensum
#16
Guo Sun, Qin Dai, Hong-Xia Zhang, Zhi-Jian Li, Zhi-Zhi Du
Ten novel C21 pregnane glycosides, extensumside C-L (1-10), were isolated as highly sweet-tasting substances from the edible pericarps of Myriopteron extensum (Wight) K. Schum by sensory-guided fractionation and purification. Their structures were determined through 1D and 2D NMR, such as HSQC, HMBC, (1)H-(1)H COSY, HSQC-TOCSY, and ROESY, as well as other spectroscopic analysis combined with chemical evidence. These compounds shared the same aglycone, 3β,16α-dihydroxy-pregn-5-en-20-one, and contained the deoxysugar chain and the glucose chain which were linked to C-3 and C-16 of the aglycone, respectively...
December 14, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27935990/hyperalgesia-and-persistent-pain-after-breast-cancer-surgery-a-prospective-randomized-controlled-trial-with-perioperative-cox-2-inhibition
#17
Noud van Helmond, Monique A Steegers, Gertie P Filippini-de Moor, Kris C Vissers, Oliver H Wilder-Smith
BACKGROUND: Persistent pain is a challenging clinical problem after breast cancer treatment. After surgery, inflammatory pain and nociceptive input from nerve injury induce central sensitization which may play a role in the genesis of persistent pain. Using quantitative sensory testing, we tested the hypothesis that adding COX-2 inhibition to standard treatment reduces hyperalgesia after breast cancer surgery. A secondary hypothesis was that patients developing persistent pain would exhibit more postoperative hyperalgesia...
2016: PloS One
https://www.readbyqxmd.com/read/27927698/decision-related-activity-in-macaque-v2-for-fine-disparity-discrimination-is-not-compatible-with-optimal-linear-read-out
#18
Stephane Clery, Bruce G Cumming, Hendrikje Nienborg
: Fine judgments of stereoscopic depth rely mainly on relative judgments of depth (relative binocular disparity) between objects, rather than judgments of the distance to where the eyes are fixating (absolute disparity). In macaques, visual area V2 is the earliest site in the visual processing hierarchy for which neurons selective for relative disparity have been observed (Thomas et al, 2002). Here, we found that in macaques trained to perform a fine disparity discrimination task, disparity selective neurons in V2 were highly selective for the task, and their activity correlated with the animals' perceptual decisions (unexplained by the stimulus)...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27922760/nervecheck-for-the-detection-of-sensory-loss-and-neuropathic-pain-in-diabetes
#19
Georgios Ponirakis, Maria N Odriozola, Samantha Odriozola, Ioannis N Petropoulos, Shazli Azmi, Maryam Ferdousi, Hassan Fadavi, Uazman Alam, Andrew Marshall, Maria Jeziorska, Anthony Miro, Ahmad Kheyami, Mitra Tavakoli, Ahmed Al-Ahmar, Maria B Odriozola, Ariel Odriozola, Rayaz A Malik
BACKGROUND: Accurate and economic detection of nerve damage in diabetes is key to more widespread diagnosis of patients with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy. This study examined the diagnostic performance of NerveCheck, an inexpensive ($500) quantitative sensory testing (QST) device. METHODS: One hundred forty-four subjects (74 with and 70 without diabetes) underwent assessment with NerveCheck, neuropathy disability score (NDS), nerve conduction studies (NCS), intraepidermal and corneal nerve fiber density (IENFD and CNFD), and McGill questionnaire for neuropathic pain...
December 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27918337/the-effects-of-a-genital-vibratory-stimulation-device-on-sexual-function-and-genital-sensation
#20
Marsha K Guess, Kathleen A Connell, Scott Chudnoff, Olusola Adekoya, Cherrilyn Richmond, Kayla E Nixon, Katherine Freeman, Arnold Melman
OBJECTIVE: The aim of this study was to evaluate the effectiveness of a genital vibratory stimulation device in improving sexual function in women with arousal and orgasm disorders. METHODS: In this single-arm, prospective study, baseline and 1- and 3-month assessments were performed to evaluate women with sexual arousal and/or orgasmic disorders, who received therapy using a genital vibratory stimulation device. Sexual function, satisfaction, and distress were evaluated using the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale, and the Female Intervention Efficacy Index questionnaires...
December 1, 2016: Female Pelvic Medicine & Reconstructive Surgery
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