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Quantitative sensory testing

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https://www.readbyqxmd.com/read/28221302/diagnostic-criteria-for-small-fiber-neuropathy
#1
Derrick Blackmore, Zaeem A Siddiqi
OBJECTIVES: Despite its relative common occurrence, definitive diagnosis of small fiber neuropathy (SFN) remains problematic. In practice, patients with pain, numbness, and/or paresthesias in their lower limbs are diagnosed with SFN if found to have dissociated sensory loss in their feet, that is, impaired pinprick perception (PP) but relatively preserved vibration. We sought to assess the sensitivity and specificity of clinical examination and various diagnostic tools available for screening SFN...
March 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28215248/quantitative-sensory-test-for-primary-restless-legs-syndrome-willis-ekbom-disease-using-the-current-perception%C3%A2-threshold-test
#2
Yong Won Cho, Min-Sung Kang, Keun Tae Kim, So Young Do, Jung-Geun Lim, So Young Lee, Gholam K Motamedi
BACKGROUND: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sensorimotor neurological disorder, and it is especially aggravated at night. The purpose of this study was to investigate the diurnal sensory dysfunction in primary RLS/WED using the current perception threshold (CPT) test, compared to healthy controls. METHODS: Thirty primary RLS/WED subjects and 30 healthy controls were enrolled. The severity of RLS/WED and sleep problems were evaluated in all subjects...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28191033/algorithm-and-software-to-automatically-identify-latency-and-amplitude-features-of-local-field-potentials-recorded-in-electrophysiological-investigation
#3
Maria Rubega, Claudia Cecchetto, Stefano Vassanelli, Giovanni Sparacino
BACKGROUND: Local field potentials (LFPs) evoked by sensory stimulation are particularly useful in electrophysiological research. For instance, spike timing and current transmembrane current flow estimated from LFPs recorded in the barrel cortex in rats and mice are exploited to investigate how the brain represents sensory stimuli. Recent improvements in microelectrodes technology enable neuroscientists to acquire a great amount of LFPs during the same experimental session, calling for algorithms for their quantitative automatic analysis...
2017: Source Code for Biology and Medicine
https://www.readbyqxmd.com/read/28187102/physical-activity-behavior-predicts-endogenous-pain-modulation-in-older-adults
#4
Kelly M Naugle, Thomas Ohlman, Keith E Naugle, Zachary A Riley, NiCole R Keith
Older adults compared with younger adults are characterized by greater endogenous pain facilitation and a reduced capacity to endogenously inhibit pain, potentially placing them at a greater risk for chronic pain. Previous research suggests that higher levels of self-reported physical activity are associated with more effective pain inhibition and less pain facilitation on quantitative sensory tests in healthy adults. However, no studies have directly tested the relationship between physical activity behavior and pain modulatory function in older adults...
March 2017: Pain
https://www.readbyqxmd.com/read/28181856/repeatability-of-quantitative-sensory-testing-in-healthy-cats-in-a-clinical-setting-with-comparison-to-cats-with-osteoarthritis
#5
Elena S Addison, Dylan N Clements
Objectives The aim of this study was to evaluate the repeatability of quantitative sensory tests (QSTs) in a group of healthy untrained cats (n = 14) and to compare the results with those from cats with osteoarthritis (n = 7). Methods Peak vertical force (PVF) and vertical impulse were measured on a pressure plate system. Thermal sensitivity was assessed using a temperature-controlled plate at 7°C and 40°C. Individual paw lifts and overall duration of paw lifts were counted and measured for each limb. Paw withdrawal thresholds were measured using manual and electronic von Frey monofilaments (MVF and EVF, respectively) applied to the metacarpal or metatarsal pads...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28181242/sensory-profile-and-consumer-acceptability-of-prebiotic-white-chocolate-with-sucrose-substitutes-and-the-addition-of-goji-berry-lycium-barbarum
#6
Janaína Madruga Morais Ferreira, Bruna Marcacini Azevedo, Valdecir Luccas, Helena Maria André Bolini
Functional food is a product containing nutrients that provide health benefits beyond basic nutrition. The objective of the present study was to evaluate the descriptive sensory profile and consumers' acceptance of functional (prebiotic) white chocolates with and without the addition of an antioxidant source (goji berry [GB]) and sucrose replacement. The descriptive sensory profile was determined by quantitative descriptive analysis (QDA) with trained assessors (n = 12), and the acceptance test was performed with 120 consumers...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28162413/-187-normative-values-for-quantitative-sensory-testing-in-african-americans
#7
M Ezenwa, Y Yao, M Suarez, Z Zhao, J Carrasco, V Angulo, D Shuey, K Roach, Z Wang, R Molokie, D Wilkie
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161767/pain-extent-is-associated-with-pain-intensity-but-not-with-widespread-pressure-or-thermal-pain-sensitivity-in-women-with-fibromyalgia-syndrome
#8
Marco Barbero, César Fernández-de-Las-Peñas, María Palacios-Ceña, Corrado Cescon, Deborah Falla
Widespread pain is considered a sign of central sensitization in people with chronic pain. Our aim was to examine whether pain extent, assessed from the pain drawing, relates to measures from quantitative sensory testing in fibromyalgia syndrome (FMS). Thirty women with FMS and no other co-morbid conditions completed pain drawings (dorsal and ventral views) and clinical and related disability questionnaires. Pain extent and pain frequency maps were obtained from the pain drawings using a novel customized software...
February 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28160223/quantitative-sensory-testing-in-adults-with-autism-spectrum-disorders
#9
Odette Fründt, Wiebke Grashorn, Daniel Schöttle, Ina Peiker, Nicole David, Andreas K Engel, Katarina Forkmann, Nathalie Wrobel, Alexander Münchau, Ulrike Bingel
Altered sensory perception has been found in patients with autism spectrum disorders (ASD) and might be related to aberrant sensory perception thresholds. We used the well-established, standardized Quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain to investigate 13 somatosensory parameters including thermal and tactile detection and pain thresholds in 13 ASD adults and 13 matched healthy controls with normal IQ values. There were no group differences between somatosensory detection and pain thresholds...
February 3, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28158269/predictors-of-opioid-efficacy-in-patients-with-chronic-pain-a-prospective-multicenter-observational-cohort-study
#10
Kasper Grosen, Anne E Olesen, Mikkel Gram, Torsten Jonsson, Michael Kamp-Jensen, Trine Andresen, Christian Nielsen, Gorazd Pozlep, Mogens Pfeiffer-Jensen, Bart Morlion, Asbjørn M Drewes
Opioids are increasingly used for treatment of chronic pain. However, they are only effective in a subset of patients and have multiple side effects. Thus, studies using biomarkers for response are highly warranted. The current study prospectively examined 63 opioid-naïve patients initiating opioid use for diverse types of chronic pain at five European centers. Quantitative sensory testing, electroencephalography (EEG) recordings, and assessment of pain catastrophizing were performed prior to treatment. The co-primary outcomes were change from baseline in ratings of chronic pain and quality of life after 14 days of opioid treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28153311/multiple-internal-standard-normalization-for-improving-hs-spme-gc-ms-quantitation-in-virgin-olive-oil-volatile-organic-compounds-voo-vocs-profile
#11
Martina Fortini, Marzia Migliorini, Chiara Cherubini, Lorenzo Cecchi, Luca Calamai
The commercial value of virgin olive oils (VOOs) strongly depends on their classification, also based on the aroma of the oils, usually evaluated by a panel test. Nowadays, a reliable analytical method is still needed to evaluate the volatile organic compounds (VOCs) and support the standard panel test method. To date, the use of HS-SPME sampling coupled to GC-MS is generally accepted for the analysis of VOCs in VOOs. However, VOO is a challenging matrix due to the simultaneous presence of: i) compounds at ppm and ppb concentrations; ii) molecules belonging to different chemical classes and iii) analytes with a wide range of molecular mass...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28148644/characteristics-of-the-local-cutaneous-sensory-thermo-neutral-zone
#12
Davide Filingeri, Hui Zhang, Edward A Arens
Skin temperature detection thresholds have been used to measure human cold and warm sensitivity across the temperature continuum. They exhibit a sensory zone within which neither warm nor cold sensations prevail. This zone has been widely assumed to coincide with steady-state local skin temperatures between 32-34ᵒC, but its underlying neurophysiology has been rarely investigated. Here we employ two approaches to characterize the properties of sensory thermo-neutrality, testing for each whether neutrality shifts along the temperature continuum depending on adaptation to a preceding thermal state...
February 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28146319/unimpaired-endogenous-pain-inhibition-in-the-early-phase-of-complex-regional-pain-syndrome
#13
N Kumowski, T Hegelmaier, J Kolbenschlag, C Maier, T Mainka, J Vollert, E Enax-Krumova
BACKGROUND: The complex regional pain syndrome (CRPS) is characterized by distal generalisation of pain beyond the initial trauma. This might be the result of impaired endogenous pain inhibition. METHOD: We compared Conditioned Pain Modulation (CPM) between patients with CRPS (n = 24; pain: 4.5 ± 2.2, NRS 0-10; disease duration <1 year), neuralgia (n = 17; pain: 5.5 ± 1.1) and healthy subjects (n = 23) and its correlation with loss and gain of function as assessed by Quantitative Sensory Testing (QST)...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28131214/quantitative-sensory-testing-and-structural-assessment-of-sensory-nerve-fibres-in-amyotrophic-lateral-sclerosis
#14
Baris Isak, Kirsten Pugdahl, Páll Karlsson, Hatice Tankisi, Nanna Brix Finnerup, Jasna Furtula, Birger Johnsen, Niels Sunde, Johannes Jakobsen, Anders Fuglsang-Frederiksen
OBJECTIVE: In this prospective study, involvement of sensory nerve fibres in ALS patients was assessed using functional and structural measures in the form of quantitative sensory testing (QST) and skin and nerve biopsies. METHODS: Thirty-two ALS patients and 32 healthy subjects were evaluated with a QST battery comprising thresholds of mechanical detection, mechanical pain, vibration detection, cold detection, warm detection, heat pain, and pinprick sensation. Skin biopsies were evaluated in 31 ALS patients by intraepidermal nerve fibre density (IENFD) and axonal swelling ratios, and growth-associated protein 43 (GAP-43) antibody staining...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28129214/biomarkers-of-neuropathic-pain-in-skin-nerve-degeneration-neuropathy-contact-heat-evoked-potentials-as-a-physiological-signature
#15
Shao-Wei Wu, Yi-Chia Wang, Paul-Chen Hsieh, Ming-Tsung Tseng, Ming-Chang Chiang, Chih-Pang Chu, Fang-Ping Feng, Yea-Huey Lin, Sung-Tsang Hsieh, Chi-Chao Chao
Contact heat-evoked potentials (CHEPs) have become an established method of assessing small-fiber sensory nerves; however, their potential as a physiological signature of neuropathic pain symptoms has not been fully explored. To investigate the diagnostic efficacy in examining small-fiber sensory nerve degeneration, the relationship with skin innervations, and clinical correlates with sensory symptoms, we recruited 188 patients (115 men) with length-dependent sensory symptoms and reduced intraepidermal nerve fiber (IENF) density at the distal leg to perform CHEP, quantitative sensory testing, and nerve conduction study...
March 2017: Pain
https://www.readbyqxmd.com/read/28128860/assessment-of-small-sensory-fiber-function-across-the-spectrum-of-severity-in-carpal-tunnel-syndrome-patients
#16
Christopher Clarke, Christopher Christensen, Matthew W T Curran, K Ming Chan
INTRODUCTION: In compressive neuropathies, large myelinated nerve fibers are generally thought to be more susceptible. In this study, we investigated small myelinated Aδ and unmyelinated C fiber function in patients with mild, moderate, and severe carpal tunnel syndrome. METHODS: Forty-four healthy controls and 81 carpal tunnel syndrome patients in the mild, moderate, or severe categories were recruited. Small fiber sensation in the affected hand was determined with quantitative sensory testing...
January 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28122090/spatial-and-global-sensory-suppression-mapping-encompassing-the-central-10%C3%A2-field-in-anisometropic-amblyopia
#17
Jingjing Li, Jinrong Li, Zidong Chen, Jing Liu, Junpeng Yuan, Xiaoxiao Cai, Daming Deng, Minbin Yu
Purpose: We investigate the efficacy of a novel dichoptic mapping paradigm in evaluating visual function of anisometropic amblyopes. Methods: Using standard clinical measures of visual function (visual acuity, stereo acuity, Bagolini lenses, and neutral density filters) and a novel quantitative mapping technique, 26 patients with anisometropic amblyopia (mean age = 19.15 ± 4.42 years) were assessed. Two additional psychophysical interocular suppression measurements were tested with dichoptic global motion coherence and binocular phase combination tasks...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28118424/localized-pain-hypersensitivity-in-older-women-with-cervicogenic-headache-a-quantitative-sensory-testing-study
#18
Jenjira Assapun, Sureeporn Uthaikhup
AIMS: To investigate pain sensitivity by using quantitative sensory testing in older women with and without cervicogenic headache. METHODS: A total of 18 older women (mean age ± standard deviation [SD] 64.28 ± 3.21 years) with cervicogenic headache and 17 healthy controls (65.18 ± 3.89 years) participated in the study. Pain thresholds (pressure, heat, and cold) and suprathreshold heat pain ratings (at 45° C, 47°C, and 49°C) were measured over the temporalis muscle, upper cervical spine, and tibialis anterior muscle...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28118423/effect-of-experimental-periodontal-ligament-pain-on-gingival-somatosensory-sensitivity
#19
Shengyi Lu, Peter Svensson, Zhenting Zhang, Thomas List, Lene Baad-Hansen
AIMS: To use a randomized, blinded, crossover design to evaluate the possible heterotopic effects of experimental periodontal ligament pain on adjacent gingival somatosensory sensitivity. METHODS: A total of 12 healthy volunteers (8 female, 4 male; mean age ± standard error in means (SEM): 28 ± 1 years) participated in two randomized experimental quantitative sensory testing (QST) sessions, one in which capsaicin (experimental) was injected into the periodontal ligament and one in which isotonic saline (control) was injected...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28118417/pain-from-dental-implant-placement-inflammatory-pulpitis-pain-and-neuropathic-pain-present-different-somatosensory-profiles
#20
André Luís Porporatti, Leonardo Rigoldi Bonjardim, Juliana Stuginski-Barbosa, Estevam Augusto Bonfante, Yuri Martins Costa, Paulo César Rodrigues Conti
AIMS: To address the two following questions: (1) What kind of somatosensory abnormalities may be characterized in patients receiving dental implants (IMP), in ongoing inflammatory dental pulpitis (IP) patients, and in neuropathic pain (atypical odontalgia [AO]) patients? and (2) What sort of sensory and neural changes may result from dental implant placement surgery and pulpectomy? METHODS: A total of 60 subjects were divided into three groups: the IMP (n = 20), IP (n = 20), and AO groups (n = 20)...
January 2017: Journal of Oral & Facial Pain and Headache
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