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Quantitative sensory testing

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https://www.readbyqxmd.com/read/27927698/decision-related-activity-in-macaque-v2-for-fine-disparity-discrimination-is-not-compatible-with-optimal-linear-read-out
#1
Stephane Clery, Bruce G Cumming, Hendrikje Nienborg
: Fine judgments of stereoscopic depth rely mainly on relative judgments of depth (relative binocular disparity) between objects, rather than judgments of the distance to where the eyes are fixating (absolute disparity). In macaques, visual area V2 is the earliest site in the visual processing hierarchy for which neurons selective for relative disparity have been observed (Thomas et al, 2002). Here, we found that in macaques trained to perform a fine disparity discrimination task, disparity selective neurons in V2 were highly selective for the task, and their activity correlated with the animals' perceptual decisions (unexplained by the stimulus)...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27922760/nervecheck-for-the-detection-of-sensory-loss-and-neuropathic-pain-in-diabetes
#2
Georgios Ponirakis, Maria N Odriozola, Samantha Odriozola, Ioannis N Petropoulos, Shazli Azmi, Maryam Ferdousi, Hassan Fadavi, Uazman Alam, Andrew Marshall, Maria Jeziorska, Anthony Miro, Ahmad Kheyami, Mitra Tavakoli, Ahmed Al-Ahmar, Maria B Odriozola, Ariel Odriozola, Rayaz A Malik
BACKGROUND: Accurate and economic detection of nerve damage in diabetes is key to more widespread diagnosis of patients with diabetic peripheral neuropathy (DPN) and painful diabetic neuropathy. This study examined the diagnostic performance of NerveCheck, an inexpensive ($500) quantitative sensory testing (QST) device. METHODS: One hundred forty-four subjects (74 with and 70 without diabetes) underwent assessment with NerveCheck, neuropathy disability score (NDS), nerve conduction studies (NCS), intraepidermal and corneal nerve fiber density (IENFD and CNFD), and McGill questionnaire for neuropathic pain...
December 6, 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27918337/the-effects-of-a-genital-vibratory-stimulation-device-on-sexual-function-and-genital-sensation
#3
Marsha K Guess, Kathleen A Connell, Scott Chudnoff, Olusola Adekoya, Cherrilyn Richmond, Kayla E Nixon, Katherine Freeman, Arnold Melman
OBJECTIVE: The aim of this study was to evaluate the effectiveness of a genital vibratory stimulation device in improving sexual function in women with arousal and orgasm disorders. METHODS: In this single-arm, prospective study, baseline and 1- and 3-month assessments were performed to evaluate women with sexual arousal and/or orgasmic disorders, who received therapy using a genital vibratory stimulation device. Sexual function, satisfaction, and distress were evaluated using the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale, and the Female Intervention Efficacy Index questionnaires...
December 1, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27911283/association-between-physical-activity-and-pain-processing-in-adults-with-chronic-low-back-pain-compared-to-pain-free-controls
#4
Lindsay C Orr, Steven Z George, Corey B Simon
BACKGROUND: Pain sensitivity has been negatively associated with physical activity levels. Few studies have examined associations between experimentally induced pain sensitivity and physical activity in adults with chronic low back pain and pain-free controls. OBJECTIVE: The objective of this study was to examine associations between physical activity levels and how an individual processes pain using experimentally induced pain stimuli. METHODS: Seventy subjects (CLBP = 49; mean age = 46...
November 25, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27898461/cold-pain-threshold-identifies-a-subgroup-of-patients-with-knee-osteoarthritis-that-present-with-multimodality-hyperalgesia-and-elevated-pain-levels
#5
Anthony Wright, Heather A E Benson, Rob Will, Penny Moss
OBJECTIVES: Cold hyperalgesia has been established as an important marker of pain severity in a number of conditions. This study aimed to establish the extent to which patients with knee osteoarthritis (OA) demonstrate widespread cold, heat, and pressure hyperalgesia. OA participants with widespread cold hyperalgesia were compared with the remaining OA cohort to determine whether they could be distinguished in terms of hyperalgesia, pain report, pain quality, and physical function. METHODS: A total of 80 participants with knee OA and 40 matched healthy controls participated...
November 24, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27897183/sensory-thresholds-at-different-sites-of-the-foot-a-valuable-reference-for-neurologic-examinations
#6
J-W Zhang, Q Wang, X-F Wang, M-M Gao, X-P Yun, H-F Wu, Y Hong
STUDY DESIGN: Prospective healthy volunteer study for sensory thresholds. OBJECTIVES: The aim of this study was to test sensory thresholds at different sites of the foot to provide a reference for diagnosis and neurologic classification. SETTING: A university hospital for the research and clinical practice of rehabilitation. METHODS: Thirty healthy volunteers were recruited, and quantitative sensory testing was performed on three sites of the foot (medial malleolus (for the L4 dermatome), dorsum of the foot at the third metatarsal phalangeal joint (for the L5 dermatome) and lateral heel (for the S1 dermatome))...
November 29, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27896457/the-value-of-quantitative-sensory-testing-in-spine-research
#7
Anja Tschugg, Wolfgang N Löscher, Sara Lener, Sebastian Hartmann, Matthias Wildauer, Sabrina Neururer, Claudius Thomé
The improvement of pain and functionality is the major goal of a surgical intervention. Thus, the purpose of the present prospective study was to evaluate whether subjective sensory deficits in patients with lumbar radiculopathy caused by a lumbar disc herniation are related to clinical status, using several outcome scores and the quantitative sensory testing (QST) pre- and 12 months postoperatively. We applied the QST in 52 patients with a single lumbar disc herniation treated by lumbar sequestrectomy pre- and 12 months postoperatively...
November 28, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27893485/peripheral-neuropathic-pain-a-mechanism-related-organizing-principle-based-on-sensory-profiles
#8
Ralf Baron, Christoph Maier, Nadine Attal, Andreas Binder, Didier Bouhassira, Giorgio Cruccu, Nanna B Finnerup, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S Jensen, Rainer Freynhagen, Jeffrey D Kennedy, Walter Magerl, Tina Mainka, Maren Reimer, Andrew S C Rice, Märta Segerdahl, Jordi Serra, Sören Sindrup, Claudia Sommer, Thomas Tölle, Jan Vollert, Rolf-Detlef Treede
Patients with neuropathic pain are heterogeneous in etiology, pathophysiology and clinical appearance. They exhibit a variety of pain-related sensory symptoms and signs (sensory profile). Different sensory profiles might indicate different classes of neurobiological mechanisms and hence subgroups with different sensory profiles might respond differently to treatment.The aim of the investigation was to identify subgroups in a large sample of neuropathic pain patients using hypothesis-free statistical methods on the database of three large multi-national research networks (German Research Network on Neuropathic Pain (DFNS), IMI-Europain, Neuropain)...
November 3, 2016: Pain
https://www.readbyqxmd.com/read/27872003/primary-and-secondary-provoked-vestibulodynia-a-review-of-overlapping-and-distinct-factors
#9
REVIEW
Caroline F Pukall
INTRODUCTION: A common subtype of vulvodynia is provoked vestibulodynia (PVD), characterized by severe pain upon contact to the vaginal entrance. Some researchers have further delineated the PVD group based on pain onset (primary vs secondary PVD, referred to as PVD1 and PVD2, respectively). AIM: This study aims to review available evidence regarding sociodemographic variables, pain characteristics, medical history and examination findings, quantitative sensory testing, genetic markers, psychosocial/sexual/relationship function, treatment outcome, and brain imaging in women with PVD1 and PVD2...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27811270/exploring-pain-pathophysiology-in-patients
#10
REVIEW
Claudia Sommer
Although animal models of pain have brought invaluable information on basic processes underlying pain pathophysiology, translation to humans is a problem. This Review will summarize what information has been gained by the direct study of patients with chronic pain. The techniques discussed range from patient phenotyping using quantitative sensory testing to specialized nociceptor neurophysiology, imaging methods of peripheral nociceptors, analyses of body fluids, genetics and epigenetics, and the generation of sensory neurons from patients via inducible pluripotent stem cells...
November 4, 2016: Science
https://www.readbyqxmd.com/read/27808438/warm-hands-cold-heart-progressive-whole-body-cooling-increases-warm-thermosensitivity-of-human-hands-and-feet-in-a-dose-dependent-fashion
#11
Davide Filingeri, Nathan B Morris, Ollie Jay
While inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has been unexplored. Hence, we tested whether progressive decreases in whole-body mean skin temperature (Tsk ) (a large conditioning stimulus) alter the magnitude estimation of local warming and cooling stimuli applied to hairy and glabrous skin. On 4 separate occasions, 8 males (27 ± 5y) underwent a 30-min whole-body cooling protocol (water-perfused-suit; temperature: 5 C), during which a quantitative thermosensory test, consisting of reporting perceived magnitude of warming and cooling stimuli (±8°C from 30°C baseline) applied to the hand (palm/dorsum) and foot (sole/dorsum), was performed before cooling and every 10 min thereafter...
November 3, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27803377/nerve-grafts-bridging-the-thenar-branch-of-the-median-nerve-to-the-ulnar-nerve-to-enhance-nerve-recovery-a-report-of-three-cases
#12
B Gesslbauer, G J Furtmüller, O Schuhfried, A D Roche, M Sporer, O C Aszmann
: We report a nerve graft procedure bridging the thenar branch of the median nerve to the ulnar nerve in three patients with ulnar nerve transection and defect at the mid-forearm. Ulnar nerve function was evaluated with electroneurography and quantitative sensory-motor testing before and after surgery, and at a 6-year follow-up. After surgery all patients showed electroneurographic evidence of median nerve innervation of the intrinsic muscles normally innervated by the ulnar nerve. The average strength was Grade 4 in the intrinsic muscles originally supplied by the ulnar nerve at the final follow-up...
October 31, 2016: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/27802497/association-between-metabolic-syndrome-components-and-polyneuropathy-in-an-obese-population
#13
Brian C Callaghan, Rong Xia, Evan Reynolds, Mousumi Banerjee, Amy E Rothberg, Charles F Burant, Emily Villegas-Umana, Rodica Pop-Busui, Eva L Feldman
Importance: Past studies have shown an association between metabolic syndrome and polyneuropathy, but the precise components that drive this association remain unclear. Objectives: To determine the prevalence of polyneuropathy stratified by glycemic status in well-characterized obese and lean participants and investigate the association of specific components of metabolic syndrome with polyneuropathy. Design, Setting, and Participants: We performed a cross-sectional, observational study from November 1, 2010, to December 31, 2014, in obese participants (body mass index [calculated as weight in kilograms divided by height in meters squared] of 35 or more with no comorbid conditions or 32 or more with at least 1 comorbid condition) from a weight management program and lean controls from a research website...
October 31, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27797669/mindful-yoga-pilot-study-shows-modulation-of-abnormal-pain-processing-in-fibromyalgia-patients
#14
James W Carson, Kimberly M Carson, Kim D Jones, Lindsay Lancaster, Scott D Mist
Published findings from a randomized controlled trial have shown that Mindful Yoga training improves symptoms, functional deficits, and coping abilities in individuals with fibromyalgia and that these benefits are replicable and can be maintained 3 months post-treatment. The aim of this study was to collect pilot data in female fibromyalgia patients (n = 7) to determine if initial evidence indicates that Mindful Yoga also modulates the abnormal pain processing that characterizes fibromyalgia. Pre- and post-treatment data were obtained on quantitative sensory tests and measures of symptoms, functional deficits, and coping abilities...
January 2016: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/27792116/characteristics-of-residual-symptoms-following-laminoplasty-in-diabetic-patients-with-cervical-spondylotic-myelopathy-a-prospective-cohort-study
#15
Masaaki Machino, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Satoshi Tanaka, Masayoshi Morozumi, Keigo Ito, Fumihiko Kato, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: A prospective cohort study OBJECTIVE.: The purpose of this study was to compare cervical laminoplasty outcomes between diabetic and non-diabetic patients with cervical spondylotic myelopathy (CSM), and to characterize residual symptoms of diabetic patients. METHODS: A total of 505 consecutive patients with CSM (331 males, 189 females; mean age, 66.6 years; range, 41-91 years; > 1-year follow-up after laminoplasty) were enrolled and divided into diabetic group (n = 105) and non-diabetic group (n = 400)...
October 25, 2016: Spine
https://www.readbyqxmd.com/read/27786536/a-dual-trace-model-for-visual-sensory-memory
#16
Marcus Cappiello, Weiwei Zhang
Visual sensory memory refers to a transient memory lingering briefly after the stimulus offset. Although previous literature suggests that visual sensory memory is supported by a fine-grained trace for continuous representation and a coarse-grained trace of categorical information, simultaneous separation and assessment of these traces can be difficult without a quantitative model. The present study used a continuous estimation procedure to test a novel mathematical model of the dual-trace hypothesis of visual sensory memory according to which visual sensory memory could be modeled as a mixture of 2 von Mises (2VM) distributions differing in standard deviation...
November 2016: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/27780176/a-population-based-study-of-quantitative-sensory-testing-in-adolescents-with-and-without-chronic-pain
#17
See Wan Tham, Tonya M Palermo, Amy Lewandowski Holley, Chuan Zhou, Audun Stubhaug, Anne-Sofie Furberg, Christopher Sivert Nielsen
Quantitative sensory testing (QST) has been used to characterize pain sensitivity in individuals with and without pain conditions. Research remains limited in pediatric populations, hindering the ability to expand the utility of QST toward its potential application in clinical settings and clinical predictive value. The aims of this study were to examine pain sensitivity using QST in adolescents with chronic pain compared to adolescents without chronic pain and identify predictors of pain sensitivity. A population-based study conducted from 2010 to 2011 provided data on 941 adolescents, 197 were classified as having chronic pain and 744 were classified without chronic pain...
September 15, 2016: Pain
https://www.readbyqxmd.com/read/27776990/functional-characterization-of-at-level-hypersensitivity-in-patients-with-spinal-cord-injury
#18
Carola Vogel, Roman Rukwied, Lenka Stockinger, Marcus Schley, Martin Schmelz, Wolfgang Schleinzer, Christoph Konrad
: At-level and above-level hypersensitivity was assessed in patients with chronic complete thoracic spinal cord injury (SCI). Patients were classified using somatosensory mapping (brush, cold, pinprick) and assigned into 2 groups (ie, patients with at-level hypersensitivity [SCIHs, n = 8] and without at-level hypersensitivity [SCINHs, n = 7]). Gender and age-matched healthy subjects served as controls. Quantitative sensory testing (QST), electrically- and histamine-induced pain and itch, laser Doppler imaging, and laser-evoked potentials (LEP) were recorded at-level and above-level in SCI-patients...
October 22, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27771034/efficacy-of-retroperitoneal-triple-neurectomy-for-refractory-neuropathic-inguinodynia
#19
Alexandra M Moore, Martin F Bjurstrom, Jonathan R Hiatt, Parviz K Amid, David C Chen
BACKGROUND: Refractory neuropathic inguinodynia following inguinal herniorrhaphy is a common and debilitating complication. This prospective study evaluated long-term outcomes associated with laparoscopic retroperitoneal triple neurectomy. METHODS: Sixty-two consecutive patients (51 male; mean age, 47); all failing pain management; prior reoperation in 35, prior neurectomy in 26; average follow-up 681 days (range: 90 days to 3 years). Measured outcomes include numeric pain ratings, dermatomal mapping, histologic confirmation, quantitative sensory testing, complications, narcotic usage, and activity level...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27770480/agreement-between-quantitative-and-qualitative-sensory-testing-of-changes-in-oro-facial-somatosensory-sensitivity
#20
J Agbaje, A De Laat, P Constantinus, P Svensson, L Baad-Hansen
Qualitative somatosensory testing (QualST) is a simple chairside test. It can be used to roughly assess the presence or absence of altered somatosensory function. To use QualST clinically, it is important to assess its agreement with quantitative sensory testing (QST). The aims of this study were to assess the agreement between QST and QualST when testing the modulation of facial sensitivity by capsaicin in healthy participants and to explore the agreement between QST and QualST in assessing the intraoral sensory function in clinical atypical odontalgia (AO) patients...
October 22, 2016: Journal of Oral Rehabilitation
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