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Kun Gao, Colin McGinty, Harold Payson, Shaun Berry, Joseph Vornehm, Valerie Finnemeyer, Brian Roberts, Philip Bos
We have previously shown through simulation that an optical beam deflector based on the Pancharatnam (geometric) phase can provide high efficiency with up to 80° deflection using a dual-twist structure for polarization-state control [Appl. Opt.54, 10035 (2015)]. In this report, we demonstrate that its optical performance is as predicted and far beyond what could be expected for a conventional diffractive optical device. We provide details about construction and characterization of a ± 40° beam-steering device with 90% diffraction efficiency based on our dual-twist design at a 633nm wavelength...
March 20, 2017: Optics Express
Brian J McGrory, Abigail M Payson, Johanna A MacKenzie
BACKGROUND: Failed total hip arthroplasty (THA) caused by mechanically assisted crevice corrosion (MACC) has serious consequences such as adverse local tissue reaction (ALTR). Serum cobalt (Co) and chromium (Cr) ion levels have been used to diagnose taper corrosion, but have not been shown to be an accurate measure of the severity of MACC or associated ALTRs. Additionally, elevated serum ions are not specific in patients with multiple artificial joints. METHODS: We examined the relationship between serum and intra-articular (IA) Co and Cr levels in a cohort of 20 patients undergoing revision THA, 16 who had symptomatic MACC...
May 2017: Journal of Arthroplasty
(no author information available yet)
The ED at Banner Payson Medical Center in Payson, AZ, has charted dramatic improvements on key metrics through a range of staff and policy changes. In just a few months, the ED has halved wait times, patient satisfaction has improved, and daily volume is up. Administrators say the secret to the success of the effort is a move to be transparent by posting key metrics regarding patient flow, a tactic that has helped the team pull together and feel a sense of accomplishment when performance goals are achieved...
May 2016: ED Management: the Monthly Update on Emergency Department Management
George Patounakis, Meghan C Ozcan, Rebecca J Chason, John M Norian, Mark Payson, Alan H DeCherney, Belinda J Yauger
OBJECTIVE: To determine whether a history of prior cesarean delivery (CD) makes ET more difficult and impacts pregnancy outcomes. DESIGN: Prospective cohort study. SETTING: Tertiary care military facility. PATIENT(S): One hundred ninety-four patients with previous delivery undergoing IVF/intracytoplasmic sperm injection (ICSI)-ET. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live birth (primary), positive hCG, clinical pregnancy, and time to perform ET...
August 2016: Fertility and Sterility
Winifred Mak, Laxmi A Kondapalli, Gerard Celia, John Gordon, Michael DiMattina, Mark Payson
STUDY QUESTION: Are perinatal outcomes improved in singleton pregnancies resulting from fresh embryo transfers performed following unstimulated/natural cycle IVF (NCIVF) compared with stimulated IVF? SUMMARY ANSWER: Infants conceived by unstimulated/NCIVF have a lower risk of being low birthweight than infants conceived by stimulated IVF; however, this risk did not remain significant after adjusting for gestation age. WHAT IS ALREADY KNOWN: Previous studies have shown that infants born after modified NCIVF have a higher average birthweight and are less likely to be low birthweight than those infants conceived with conventional stimulated IVF...
April 2016: Human Reproduction
Ryan J Heitmann, Micah J Hill, Aidita N James, Tim Schimmel, James H Segars, John M Csokmay, Jacques Cohen, Mark D Payson
Infertility is a common disease, which causes many couples to seek treatment with assisted reproduction techniques. Many factors contribute to successful assisted reproduction technique outcomes. One important factor is laboratory environment and air quality. Our facility had the unique opportunity to compare consecutively used, but separate assisted reproduction technique laboratories, as a result of a required move. Environmental conditions were improved by strategic engineering designs. All other aspects of the IVF laboratory, including equipment, physicians, embryologists, nursing staff and protocols, were kept constant between facilities...
September 2015: Reproductive Biomedicine Online
Sheldon Lee Gosline
No abstract text is available yet for this article.
January 2015: Annals of Science
Brian L Hood, Baoquan Liu, Addie Alkhas, Yutaka Shoji, Rusheeswar Challa, Guisong Wang, Susan Ferguson, Julie Oliver, Dave Mitchell, Nicholas W Bateman, Christopher M Zahn, Chad A Hamilton, Mark Payson, Bruce Lessey, Asgerally T Fazleabas, G Larry Maxwell, Thomas P Conrads, John I Risinger
Despite its importance in reproductive biology and women's health, a detailed molecular-level understanding of the human endometrium is lacking. Indeed, no comprehensive studies have been undertaken to elucidate the important protein expression differences between the endometrial glandular epithelium and surrounding stroma during the proliferative and midsecretory phases of the menstrual cycle. We utilized laser microdissection to harvest epithelial cells and stromal compartments from proliferative and secretory premenopausal endometrial tissue and performed a global, quantitative mass spectrometry-based proteomics analysis...
April 2015: Biology of Reproduction
Juan Montoya, Antonio Sanchez-Rubio, Robert Hatch, Harold Payson
We demonstrate a ladar with 0.5 m class range resolution obtained by integrating a continuous-wave optical phased-array transmitter with a Geiger-mode avalanche photodiode receiver array. In contrast with conventional ladar systems, an array of continuous-wave sources is used to effectively pulse illuminate a target by electro-optically steering far-field fringes. From the reference frame of a point in the far field, a steered fringe appears as a pulse. Range information is thus obtained by measuring the arrival time of a pulse return from a target to a receiver pixel...
November 1, 2014: Applied Optics
Michael DiMattina, John David Gordon, Awie Botes, Gerald Celia, Mark Payson, Jennifer Graves-Herring
OBJECTIVE: To describe clinical thresholds for follicle size and estradiol levels to optimize success with natural cycle in vitro fertilization (NCIVF). STUDY DESIGN: Descriptive cohort of candidates for stimulated IVF, < 43 years old, with regular menstrual cycles, regardless of ovarian reserve or fertility treatment history. Patients underwent NCIVF, defined as oocyte retrieval, fertilization and embryo transfer after human chorionic gonadotropin (hCG) trigger without luteinizing hormone (LH) suppression or ovarian stimulation medications...
May 2014: Journal of Reproductive Medicine
Gary Levy, Micah Hill, Stephanie Beall, Justin D Pilgrim, Mark Payson, Anthony Propst
OBJECTIVE: To determine whether a fall in serum estradiol levels the day after human chorionic gonadotropin (hCG) administration correlated with the incidence of a positive serum hCG in fresh, nondonor assisted reproductive technology (ART) cycles. STUDY DESIGN: A total of 1,969 women undergoing fresh, nondonor ART cycles at a tertiary referral fertility clinic between January 1, 2003, and January 31, 2010, were included and retrospectively analyzed. Primary outcome measures were oocyte maturity and positive serum beta-hCG...
May 2014: Journal of Reproductive Medicine
John David Gordon, Michael DiMattina, Andrea Reh, Awie Botes, Gerard Celia, Mark Payson
OBJECTIVE: To examine the utilization and outcomes of natural cycle (unstimulated) IVF as reported to the Society of Assisted Reproductive Technology (SART) in 2006 and 2007. DESIGN: Retrospective analysis. SETTING: Dataset analysis from the SART Clinical Outcome Reporting System national database. PATIENT(S): All patients undergoing IVF as reported to SART in 2006 and 2007. INTERVENTION(S): None...
August 2013: Fertility and Sterility
Chad Cherington, Steven R Schuster, Madappa Kundranda, Riccardo Valdez, Ruben A Mesa, Donald W Northfelt
An 82-year-old male presented to the emergency department with an acute onset of chest pain and mild shortness of breath at rest. The pain in his left lower chest was pleuritic with intensity 9- on a 10-point scale. He had driven 2 h in his car that day, but had no other prolonged immobility. About 15 years previously, he was found to have increased hemoglobin (18.1 g/dL) and diagnosed with secondary erythrocytosis due to active smoking, chronic obstructive pulmonary disease (COPD), and residence in Payson, Arizona (altitude 4,999 ft)...
June 2013: American Journal of Hematology
John M Andrick
In the summer of 1890, news that two students at Lasell Seminary for Young Women in Auburndale, MA had suffered a complete nervous collapse as a result of being hypnotized by an instructor in a nerve training class caused a brief but sharp national sensation regarding hypnotism and nerve training in girls' education. The instructor, Annie Payson Call, denied practicing hypnotism, and the seminary's principal defended both Call and the "mind concentration" course she taught at Lasell. Call's approach to nerve training blended Delsartean relaxation exercises, New Thought psychology, and self-hypnotic techniques into a therapeutic regimen which can be termed "Delsartean hypnosis...
May 2012: History of Psychology
Micah J Hill, Rebecca J Chason, Mark D Payson, James H Segars, John M Csokmay
Gonadotrophin-releasing hormone (GnRH) antagonist rescue is performed by replacing a GnRH agonist with a GnRH antagonist in patients with rapidly rising serum oestradiol who are at risk of ovarian hyperstimulation syndrome (OHSS) during stimulation. It results in a rapid reduction in serum oestradiol, allowing for the avoidance of cycle cancellation and the continuation of exogenous gonadotrophin administration. A total of 387 patients who underwent GnRH antagonist rescue for ovarian hyperresponse were compared with 271 patients who did not receive GnRH antagonist rescue and had oestradiol concentrations >4000 pg/ml on the day of human chorionic gonadotrophin (HCG) administration...
September 2012: Reproductive Biomedicine Online
Radu Mihaila, Silvia Chang, Alan T Wei, Zhi Y Hu, Dipali Ruhela, Timothy R Shadel, Sven Duenwald, Elmer Payson, James J Cunningham, Nelly Kuklin, David J Mathre
This paper describes the use of spin centrifugation-dialysis (SCD) for small-scale concentration/purification of siRNA-lipid complexes designed for use as therapeutic agents for gene silencing. SCD consists of a two-step method for concentration, filtration and buffer exchange of lipid nanoparticles (LNP) to provide a homogeneous preparation suitable for injection. Here, we compare SCD with the more traditionally used tangential flow filtration (TFF), and demonstrate the physicochemical and biological comparability of LNPs produced with both methods...
November 25, 2011: International Journal of Pharmaceutics
John M Csokmay, Micah J Hill, Rebecca J Chason, Sasha Hennessy, Aidita N James, Jacques Cohen, Alan H Decherney, James H Segars, Mark D Payson
OBJECTIVE: To determine whether a mandatory single-blastocyst transfer (mSBT) algorithm reduced multiple gestation rates without sacrificing clinical pregnancy rates. DESIGN: Retrospective review. SETTING: U.S. university-based assisted reproductive technology (ART) program. PATIENT(S): All women younger than 38 years undergoing their first ART cycle from 2009 to 2010 with ≥4 high-grade embryos on day 3 after oocyte retrieval (patients from 2009 were the "before" group, and patients completing ART under the mSBT policy in 2010 were the "after" group)...
September 2011: Fertility and Sterility
Kara N Goldman, Kimberly S Moon, Belinda J Yauger, Mark D Payson, James H Segars, Barbara J Stegmann
OBJECTIVE: To determine a minimum number of procedures required for proficiency in oocyte retrieval and to characterize skill acquisition. DESIGN: Retrospective analysis. SETTING: Reproductive endocrinology and infertility fellowship training program. SUBJECT(S): Fellows in training from 2005 to 2007 and 2008 to 2010. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Proficiency scores were calculated by dividing the number of oocytes retrieved by oocytes expected...
June 2011: Fertility and Sterility
Jie Wei, Jeffrey Jones, Jing Kang, Ananda Card, Michael Krimm, Paula Hancock, Yi Pei, Brandon Ason, Elmer Payson, Natalya Dubinina, Mark Cancilla, Mark Stroh, Julja Burchard, Alan B Sachs, Jerome H Hochman, W Michael Flanagan, Nelly A Kuklin
Deeper knowledge of pharmacokinetic and pharmacodynamic (PK/PD) concepts for RNA therapeutics is important to streamline the drug development process and for rigorous selection of best performing drug candidates. Here we characterized the PK/PD relationship for small interfering RNAs (siRNAs) targeting luciferase by examining siRNA concentration in plasma and liver, the temporal RNA-induced silencing complex binding profiles, mRNA reduction, and protein inhibition measured by noninvasive bioluminescent imaging...
June 2011: Molecular Pharmacology
Marcy Maguire, John Csokmay, James Segars, Mark Payson, Alicia Armstrong
Studies have suggested that supplemental LH improves outcomes in assisted reproductive technology (ART) cycles. In this retrospective review, an additional 150 IU of LH activity did not improve ART outcomes in women undergoing a second round of IVF/ intracytoplasmic sperm injection (ICSI) after an initial failed cycle using 600 IU of gonadotropins.
January 2011: Fertility and Sterility
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