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https://www.readbyqxmd.com/read/28742395/highlights-from-the-biennial-international-congress-on-schizophrenia-research-icosr-march-24-march-28-2017
#1
Hakon Heimer
The 2017 International Congress on Schizophrenia Research, held in San Diego, California (March 24-28, 2017), attracted over 900 attendees from 34 countries. With the gracious assistance of Congress president James Meador-Woodruff, we bring you the following reports on the prospects for new drugs to treat schizophrenia.
2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28741740/ultrafine-fine-and-black-carbon-particle-concentrations-in-california-child-care-facilities
#2
Fraser W Gaspar, Randy Maddalena, Jeffery Williams, Rosemary Castorina, Zhong-Min Wang, Kazukiyo Kumagai, Thomas E McKone, Asa Bradman
Although many U.S. children spend time in child care, little information exists on exposures to airborne particulate matter (PM) in this environment, even though PM may be associated with asthma and other respiratory illness, which is a key concern for young children. To address this data gap, we measured ultrafine particles (UFP), PM2.5 , PM10 , and black carbon in 40 California child care facilities and examined associations with potential determinants. We also tested a low-cost optical particle measuring device (Dylos monitor)...
July 25, 2017: Indoor Air
https://www.readbyqxmd.com/read/28741086/statewide-policy-change-in-pediatric-dental-care-and-the-impact-on-pediatric-dental-and-physician-visits
#3
Cheryl Zlotnick, Tammy Tam, Yu Ye
Introduction In 2007, the California signed legislation mandating a dental visit for all children entering kindergarten or first grade; no such mandate was made for physician visits. This study examines the impact of this policy change on the risk factors associated with obtaining pediatric dental and physician health care visits. Methods Every 2 years, California Health Interview Survey conducts a statewide survey on a representative community sample. This cross-sectional study took advantage of these data to conduct a "natural experiment" assessing the impact of this policy change on both pediatric physician and dental care visits in the past year...
July 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28740971/monolithic-lithium-disilicate-complete-single-crowns-with-feather-edge-preparation-design-in-the-posterior-region-a-multicentric-retrospective-study-up-to-12-years
#4
Johannes H Schmitz, Davide Cortellini, Stefano Granata, Marco Valenti
OBJECTIVE: This retrospective study evaluated the clinical success and survival of monolithic lithium disilicate single crowns in the posterior region fabricated with feather-edge margins and cemented with resin-based self-etching cement. METHOD AND MATERIALS: In total, 627 pressed monolithic lithium disilicate restorations on posterior teeth (110 first premolars, 151 second premolars, 240 first molars, 121 second molars, 5 third molars) were placed in 335 patients...
July 20, 2017: Quintessence International
https://www.readbyqxmd.com/read/28739421/whole-genome-sequencing-of-mycobacterium-bovis-to-obtain-molecular-fingerprints-in-human-and-cattle-isolates-from-baja-california-mexico
#5
Sarai Estrella Sandoval-Azuara, Ricardo Perea-Jacobo, Raquel Muñiz-Salazar, Suelee Robbe-Austerman, Alejandro Perera-Ortiz, Gilberto López-Valencia, Doris M Bravo, Alejandro Sanchez-Flores, Daniela Miranda-Guzmán, Carlos Alberto Flores-López, Roberto Zenteno-Cuevas, Rafael Laniado-Laborín, Fabiola Lafarga de la Cruz, Tod P Stuber
OBJECTIVES: To determine genetic diversity by comparing the whole genome sequences of M. bovis cattle and human isolates from Baja California. METHODS: We used a whole genome sequencing strategy to obtain the molecular fingerprints of 172 isolates of Mycobacterium bovis from Baja California, Mexico, of which 155 were isolated from cattle, and 17 were isolated from humans. We characterized spoligotypes in silico and evaluated single nucleotide polymorphism (SNP) differences between the isolates...
July 21, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28739299/surgical-treatment-of-acute-type-v-acromioclavicular-joint-dislocations-in-professional-athletes-an-anatomic-ligament-reconstruction-with-synthetic-implant-augmentation
#6
Ioannis K Triantafyllopoulos, Kalliopi Lampropoulou-Adamidou, Nikitas P Schizas, Eleftherios V Karadimas
BACKGROUND: Most acromioclavicular (AC) joint injuries occur in men in their third decade of life during high-speed or high-impact body contact sports. The management of acute complete AC joint dislocation is surgical. Current surgical techniques include anatomic reconstruction of the main restraints of the AC joint and aim to improve functional outcomes and to reduce the complication rate. METHODS: We present 10 cases of acute type V AC joint dislocation in professional athletes treated surgically with anatomic reconstruction of the coracoclavicular and AC ligaments and augmentation with the use of a synthetic polyester tape...
July 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28739290/implementation-of-the-canadian-ct-head-rule-and-its-association-with-use-of-computed-tomography-among-patients-with-head-injury
#7
Adam L Sharp, Brian Z Huang, Tania Tang, Ernest Shen, Edward R Melnick, Arjun K Venkatesh, Michael H Kanter, Michael K Gould
STUDY OBJECTIVE: Approximately 1 in 3 computed tomography (CT) scans performed for head injury may be avoidable. We evaluate the association of implementation of the Canadian CT Head Rule on head CT imaging in community emergency departments (EDs). METHODS: We conducted an interrupted time-series analysis of encounters from January 2014 to December 2015 in 13 Southern California EDs. Adult health plan members with a trauma diagnosis and Glasgow Coma Scale score at ED triage were included...
July 21, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28739196/developing-optimized-treatment-plans-for-patients-with-dyslipidemia-in-the-era-of-pcsk9-inhibitor-therapeutics
#8
James A Underberg, Michael J Blaha, Elizabeth J Jackson Msn, Peter H Jones
This educational content was derived from live, satellite symposium at the American College of Physicians (ACP) Internal Medicine Meeting 2017 in San Diego, California (online at http://courses.elseviercme.com/acp/702e). This activity will focus on optimized treatment plans for patients with dyslipidemia in the era of PCSK9 inhibitor therapeutics. LDL-C has been identified as an important therapeutic target to prevent the progression of atherosclerotic disease, however only 1 out of every 3 adults with high LDL-C has the condition under control...
July 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28739179/emotion-regulation-contributes-to-the-development-of-diabetes-distress-among-adults-with-type-1-diabetes
#9
Lawrence Fisher, Danielle Hessler, William Polonsky, Lisa Strycker, Susan Guzman, Vicky Bowyer, Ian Blumer, Umesh Masharani
OBJECTIVE: To demonstrate how maladaptive emotion regulation (ER) can lead to diabetes distress (DD), with subsequent effects on management and metabolic outcomes among adults with type 1 diabetes. METHODS: Data are based on pre-intervention assessment for a random controlled trial to reduce DD. Patients were recruited in California, Oregon, Arizona and Ontario, Canada. After screening and consent, patients completed an online assessment and released their most recent laboratory HbA1C...
July 8, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28738287/perceived-stress-and-poly-tobacco-product-use-across-adolescence-patterns-of-association-and-gender-differences
#10
Adam M Leventhal, Robert Urman, Jessica L Barrington-Trimis, Nicholas I Goldenson, Katia Gallegos, Chih Ping Chou, Kejia Wang, Kiros Berhane, Tess Boley Cruz, Mary Ann Pentz, Jennifer Unger, Rob S McConnell
Perceived stress-an endophenotype indicative of the tendency to appraise stress as frequent, unpredictable and unmanageable-is associated with adolescent cigarette smoking. It is unclear whether this association: (1) extends to alternative tobacco products, like electronic cigarettes and hookah (tobacco water pipe), which are increasingly popular among youth, and (2) differs by gender. In this report, data were drawn from a population-based longitudinal cohort of youth in Southern California. Perceived stress was assessed at baseline (7th or 8th grade; 2010)...
July 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28738173/simulating-the-meteorology-and-pm10-concentrations-in-arizona-dust-storms-with-the-weather-research-and-forecasting-model-with-chemistry-wrf-chem
#11
Peter Hyde, Alex Mahalov, Jialun Li
Nine dust storms in south-central Arizona, USA were simulated with the Weather Research and Forecasting with Chemistry model (WRF-Chem) at 2-km resolution. The windblown dust emission algorithm was the Air Force Weather Agency model. In comparison with ground-based PM10 observations, the model unevenly reproduces the dust storm events. The model adequately estimates the location and timing of the events, but it is unable to precisely replicate the magnitude and timing of the elevated hourly concentrations of particles 10 microns and smaller ([PM10])...
July 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28737993/the-effect-of-formulary-restrictions-on-patient-and-payer-outcomes-a-systematic-literature-review
#12
Yujin Park, Syed Raza, Aneesh George, Rumjhum Agrawal, John Ko
BACKGROUND: Formulary restrictions are implemented to reduce pharmacy costs and ensure appropriate use of pharmaceutical products. As adoption of formulary restrictions increases with rising pharmacy costs, there is a need to better understand the potential effect of formulary restrictions on patient and payer outcomes. OBJECTIVE: To conduct a systematic literature review that assesses the effect of formulary restrictions on the following outcomes: medication adherence, clinical outcomes, treatment satisfaction, drug utilization, health care resource utilization, and economic outcomes...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28737929/enhanced-degradation-of-tce-on-a-superfund-site-using-endophyte-assisted-poplar-tree-phytoremediation
#13
Sharon Lafferty Doty, John Leonard Freeman, Christopher M Cohu, Joel Gerard Burken, Andrea Firrincieli, Andrew Simon, Zareen Khan, Jud G Isebrands, Joseph Lukas, Michael J Blaylock
Trichloroethylene (TCE) is a widespread environmental pollutant common in groundwater plumes associated with industrial manufacturing areas. We had previously isolated and characterized a natural bacterial endophyte, Enterobacter sp. strain PDN3, of poplar trees, that rapidly metabolizes TCE, releasing chloride ion. We now report findings from a successful three-year field trial of endophyte-assisted phytoremediation on the Middlefield-Ellis-Whisman Superfund Study Area TCE plume in the Silicon Valley of California...
July 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28737685/microcystin-prevalence-throughout-lentic-waterbodies-in-coastal-southern-california
#14
Meredith D A Howard, Carey Nagoda, Raphael M Kudela, Kendra Hayashi, Avery Tatters, David A Caron, Lilian Busse, Jeff Brown, Martha Sutula, Eric D Stein
Toxin producing cyanobacterial blooms have increased globally in recent decades in both frequency and intensity. Despite the recognition of this growing risk, the extent and magnitude of cyanobacterial blooms and cyanotoxin prevalence is poorly characterized in the heavily populated region of southern California. Recent assessments of lentic waterbodies (depressional wetlands, lakes, reservoirs and coastal lagoons) determined the prevalence of microcystins and, in some cases, additional cyanotoxins. Microcystins were present in all waterbody types surveyed although toxin concentrations were generally low across most habitats, as only a small number of sites exceeded California's recreational health thresholds for acute toxicity...
July 22, 2017: Toxins
https://www.readbyqxmd.com/read/28737623/an-observational-study-of-severe-pertussis-in-100-infants-%C3%A2-120-days-of-age
#15
James D Cherry, Kristen Wendorf, Brooke Bregman, Deborah Lehman, Delma Nieves, John S Bradley, Wilbert H Mason, Linette Sande-Lopez, Merrick Lopez, Myke Federman, Tempe Chen, Dean Blumberg, Samantha Johnston, Hayden T Schwenk, Peggy Weintrub, Kevin K Quinn, Kathleen Winter, Kathleen Harriman
BACKGROUND: Pertussis in young infants is a unique, severe, afebrile, cough illness that is frequently fatal. METHODS: All pertussis cases ≤ 120 days of age admitted to a pediatric intensive care unit (PICU) in California between October 1, 2013 and April 25, 2015 were evaluated. RESULTS: Of 100 pertussis patients ≤ 120 days of age admitted to PICU's, there were 5 deaths. The white blood cell (WBC) counts in the fatal cases were significantly higher than in the non-fatal cases...
July 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28736970/report-from-the-2016-ucsf-center-for-reproductive-sciences-retreat
#16
Paolo Rinaudo, Marco Conti
On June 2-3, 2016, the Center for Reproductive Sciences at the University of California, San Francisco (UCSF), hosted its annual meeting in partnership with the Wiley-Blackwell Journal Molecular Reproduction and Development (MRD). The meeting was held at the Observation Post at the Presidio of San Francisco, in the Golden Gate National Recreation Area. Meeting participants included clinicians, scientists, students, and post-doctoral fellows. This article is protected by copyright. All rights reserved.
July 24, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28736796/longitudinal-research-on-aging-drivers-longroad-study-design-and-methods
#17
Guohua Li, David W Eby, Robert Santos, Thelma J Mielenz, Lisa J Molnar, David Strogatz, Marian E Betz, Carolyn DiGuiseppi, Lindsay H Ryan, Vanya Jones, Samantha I Pitts, Linda L Hill, Charles J DiMaggio, David LeBlanc, Howard F Andrews
BACKGROUND: As an important indicator of mobility, driving confers a host of social and health benefits to older adults. Despite the importance of safe mobility as the population ages, longitudinal data are lacking about the natural history and determinants of driving safety in older adults. METHODS: The Longitudinal Research on Aging Drivers (LongROAD) project is a multisite prospective cohort study designed to generate empirical data for understanding the role of medical, behavioral, environmental and technological factors in driving safety during the process of aging...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28736576/the-impact-of-considering-land-intensification-and-updated-data-on-biofuels-land-use-change-and-emissions-estimates
#18
Farzad Taheripour, Xin Zhao, Wallace E Tyner
BACKGROUND: The GTAP model has been used to estimate biofuel policy induced land use changes and consequent GHG emissions for more than a decade. This paper reviews the history of the model and database modifications and improvements that have occurred over that period. In particular, the paper covers in greater detail the move from the 2004 to the 2011 database, and the inclusion of cropland intensification in the modeling structure. RESULTS: The results show that all the changes in the global economy and agricultural sectors cause biofuels induced land use changes and associated emissions can be quite different using the 2011 database versus 2004...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28736233/continued-increase-in-melanoma-incidence-across-all-socioeconomic-status-groups-in-california-1998-2012
#19
Christina A Clarke, Meg McKinley, Susan Hurley, Robert W Haile, Sally L Glaser, Theresa H M Keegan, Susan M Swetter
Melanoma incidence has been increasing in light-skinned populations worldwide, but the reasons for the increase have been controversial. Our prior assessment in California non-Hispanic whites showed substantial increases in invasive melanoma incidence for tumors of all thicknesses in all neighborhoods categorized by socioeconomic status (SES) between 1988-1992 and 1998-2002. To understand whether these trends continued, we updated our assessment to include the diagnosis period 2008-2012 and more accurate pathologic stage at diagnosis...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28735778/yoga-for-military-veterans-with-chronic-low-back-pain-a-randomized-clinical-trial
#20
Erik J Groessl, Lin Liu, Douglas G Chang, Julie L Wetherell, Jill E Bormann, J Hamp Atkinson, Sunita Baxi, Laura Schmalzl
INTRODUCTION: Chronic low back pain (cLBP) is prevalent, especially among military veterans. Many cLBP treatment options have limited benefits and are accompanied by side effects. Major efforts to reduce opioid use and embrace nonpharmacological pain treatments have resulted. Research with community cLBP patients indicates that yoga can improve health outcomes and has few side effects. The benefits of yoga among military veterans were examined. DESIGN: Participants were randomized to either yoga or delayed yoga treatment in 2013-2015...
July 17, 2017: American Journal of Preventive Medicine
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